WO2012057417A1

WO2012057417A1 - Composition containing okamejei kenojei extract

Info

Publication number: WO2012057417A1
Application number: PCT/KR2011/002269
Authority: WO
Inventors: 박용순
Original assignee: Park Soon Yong
Priority date: 2010-10-29
Filing date: 2011-04-01
Publication date: 2012-05-03
Also published as: WO2012057417A8

Abstract

The present invention relates to a composition containing Okamejei kenojei extract, and more particularly, to a composition which contains Okamejei kenojei extract as an active for treating skin diseases such as acne, treating gray hair caused by skin toxins, relieving pain in the back, knees, and shoulders, and treating toothaches resulting from gum infections as well as fevers associated with rhinovirus and influenza.

Description

【Specification】

[Name of invention]

Composition containing Humpback Extract

Technical Field

<1> The present invention relates to a composition containing a skate oil extract and related uses for treating the disease by the composition, more specifically, by containing the skate oil extract as an active ingredient to the outside of the body toxin generated by heat in the body The present invention relates to a composition for treating skin diseases of acne vulgaris, treatment of white hair by skin toxins, pain relief of back, knee and shoulders, and cold soreness caused by toothache and heat caused by inflammation of the gums.

Background Art

Toxins are harmful organic substances caused by decay of meat or protein. The toxins are caused by the foods ingested and then moved and detoxified in the body, but are not 100% detoxified. The undetoxified toxins are inherent to the head due to vaporization, and the intrinsic toxins are somewhat different depending on the part of the body at the time of sleep, not at the time of activity. do.

<3> In particular, food poisoned by humans is converted into energy, which causes heat poisoning. If these heat poisons are not properly released, acne, red spots, black spots, hives, sweat bands, etc. are formed on the skin. It is one of several causes of aging, such as fading into gray hair. In particular, most of the toxins appear red, but strong toxins appear as black spots. These toxins rise to point of interest when exposed to strong sunlight and cause headaches and body aches as they contract when cold air enters. Toxins can cause pain in some parts of the body, and can also produce monguri. In the case of the waist, monguri produced by toxins may cause pain by compressing nerves, and sporadic toxins are newly formed in areas including the waist and the physical loss, causing frequent pain. In the case of men, fifty dogs improve after fifty dogs, and in some cases, algae are similarly produced under the nipple.

The inventors have divided the heat poison inherent in the head into four stages according to the strength of the heat poison.

<5> to Step 1 is ^"separated by nasal discharge and is discharged.

<6> The second stage causes inflammation of the eyes and gums and is an inherent inflammation that causes odors and headaches. Causes inflammation. Inflammation does not go well to the skin but when the medicine is applied to the scalp to sleep, it is discharged to the gums, fingers or toes.

<7> The third stage is the acne on the face and the point of interest when sleeping outside the active time, and the heat poisoning inherent in the head and the lower part of the body and the whole body loss. This poison can cause the nails and toenails to rise up in the early stages, and in the middle stages, the bends and fragments appear white and appear red in the area, and in severe cases black nails.

In the fourth stage, the third heat poison, which is embedded in the lower layer of the whole body, like the vaginal fog, comes to the point of interest when exposed to strong sunlight, and the fourth toxin is discolored into the spot and the black spots.

<9> The heat poison inherent in the head and the lower part of the body and the whole body's skin is contracted when hit with cold air, causing fatigue, headache and body aches.

The inventor distinguishes the pain of the human due to the poisoning as follows.

<π> In other words, the normal value of heat poisoning in the human body is assumed to be zero.

<12> In the first step, when the heat reading value is -0.2 or less, a little fatigue is felt.

In the second stage, if the readings are higher than -0.2 and below -0.7, headaches and body aches begin.

<14> In the third stage, if the reading amount is -0.7 or more and -1.0, the body is suffering from body aches.

On the other hand, the exothermic value of the skate extract is +1.

<16> The heat poison inherent in the physical loss is emitted in various forms such as pain, painlessness, and monguri, depending on the part of the body.

<17> Poisonous dogs are usually discharged in the order of nose, mouth, eyes, palms, fingers, soles, and toes. When people are tired, eyes appear red, blur the field of vision, and cause facial ups and downs. Heat-sensitive heat poisoning, when urine is excreted shakes the whole body and homeostasis occurs.

This can be seen as one of the causes of premature white hair, white eyebrows, facial wrinkles and aging.

Since white hair generally occurs as aging progresses, it gives a strong impression of old age. Therefore, a lot of dyes that blacken white hair have been studied in order to hide the generated white hair. But dyeing is back by the growth of white hair in a temporary way The oxidative type of hair dyeing agent, which has to be dyed and is currently widely used, damages the skin by the use of an oxidizing agent or the like.

The known methods of suppressing white hair include the use of black sesame, walnut meat, nasturtium and honey in combination with succinate sulfur, astronomical dong and mackmun dong; Method of maintaining the seedlings using a medicinal solution boiled at 50 ^° C in a container containing red sesame seeds, cypress leaves, sperm, nasturtium, stone salt, sage, sulfur, astronomical dong, and mackmun dong with black beans; Using black sesame, hump leaves and kelp; Using organopi extract; Using pituitary hormones; using cAMP (3 ', 5'—cyclic adenosine monophosphate); And the use of vitamin D3, etc., but the effect that can actually feel is not exhibited.

[Detailed Description of the Invention]

[Technical problem]

Accordingly, the present inventors discharge the heat poison generated by the heat from the body to the outside to discharge the heat poison inherent in the human body, restore the white hair discolored by the heat poison to black hair, Completed the present invention by relieving back and knee shoulder pain, treating skin diseases such as acne due to heat poisoning generated by body heat, treating cold soreness caused by heat, and alleviating toothache caused by gum inflammation. It became.

Accordingly, an object of the present invention is to treat skin diseases such as acne caused by heat poisoning produced by body heat, and to treat white hair and to relieve lower back, knee and shoulder pain, and to treat toothache and heat caused by gum inflammation. It is to provide a composition that can be alleviated and a related disease treatment use by the composition.

Technical Solution

In order to achieve the above object, the present invention provides a composition containing the skate extract as an active ingredient.

Advantageous Effects

The composition according to the present invention discharged the poisons inherent in the human body to the outside, restoring the white hair discolored by the heat poison to dark hair, relieving the back, knee, shoulder pain caused by the heat poisoning, and by the body heat Treatment of skin diseases such as acne caused by the discharge of heat poisoning, treatment of cold soreness caused by heat, and toothache caused by gum inflammation were alleviated.

[Brief Description of Drawings]

La to lc show the treatment effect of white hair of the smelt extract according to the present invention. Figures 2a to 2d is a photograph of observation of a heungjeol generated when artificial discharge of toxins in the arms and legs when using the skate extract according to the present invention.

Figure 3a shows the effect of treating black scars when using the skates of the present invention,

Figure 3b is a photograph of acne generated when artificially discharging the toxin, Figure 3c is a photograph confirming that the toxin is discharged from the knee.

4a to 4b are photographs confirming that the toxin is discharged from the waist area after the use of the smelt extract.

5 is a picture confirming that the gum inflammation is treated according to the taking of the extract of the pufferfish according to the present invention.

[Best form for implementation of the invention]

Hereinafter, the present invention will be described in more detail.

In general, meat produces toxins when rotting, but deciduous components are made when smelts rot. Ammonia and carbon dioxide, which are produced when smelts rot, are harmless to humans.

The present invention relates to a composition containing the smelt extract as an active ingredient.

In one embodiment of the present invention, the composition may be a composition for discharging heat poison which moves, detoxifies and discharges the heat poison in the human body.

In another embodiment of the present invention, the composition may be a composition for treating white hair by heat poison discharge.

In another embodiment of the present invention, the composition may be a composition for relieving back, knee, and shoulder pain due to heat poisoning.

In another embodiment of the present invention, the composition may be a composition for treating skin diseases such as acne by heat poisoning.

According to another embodiment of the present invention, the composition may be a therapeutic composition for treating cold soreness caused by heat poisoning.

In addition, according to another embodiment of the present invention, the composition may be a composition for treating gum inflammation to relieve toothache caused by gum inflammation.

[Form for implementation of invention]

The smelt extract used in the present invention is not only a leaching solution obtained by leaching and elution from a skate (including internal organs) but also a concentrate obtained by partially or totally concentrating the leaching liquid or a concentrate prepared by drying the above concentrate, It may contain all of the chemicals in the premises, regular, flowing extracts and smelters that have a major effect, as well as themselves. All.

For example, the smelt extract used in the present invention can be used in the form of extracts extracted with water or organic solvents, or a combination thereof by methods well known in the art. The organic solvent used in the present invention may be selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate, chloroform, and a mixed solvent of these organic solvents and water. At this time, the extraction temperature is preferably 10 ~ 100 ^° C, it can be extracted for 30 minutes to 24 hours. If the extraction temperature and extraction time is out of the extraction efficiency may decrease or change of components may occur.

In addition, the smelt extract according to the present invention includes a smelt distillate.

In this case, the skate distillate is used to keep the skate, including the viscera, at room temperature (about 15 ^° C to 25 ^° C).

Fermentation takes about 1 to 20 days.

In particular, it is fermented at room temperature (about 20 ^° C. to 25 ^° C.) for about 20 hours.

After the extraction of the distillation alcohol solution it is possible to obtain a skate distillate.

On the other hand, if the weight ratio of the smelt distillate and the smelt and water is 0.5 to 2% by weight, a mixed dilution in the ratio of 4 to 10% by weight of water becomes effective for heat poisoning fever of the human body.

In particular, 1 weight% and 5 weight ¾ »weight ratios of smelt and water were suitable for dose and treatment efficiency was good.

<48> The composition according to the invention is based on the total weight of the composition of the skate

It may be contained in 0.001-99% by weight, preferably 0.1-97% by weight, more preferably 1 to 96% by weight. If the content is less than 0.0001% by weight, the effect is insignificant, and if it exceeds 99% by weight, it is not preferable because the formulation stability worsens.

In one embodiment of the present invention, the composition may be a cosmetic. When the composition of the present invention is applied to cosmetics, it may contain a cosmetically acceptable medium or base. These are all formulations suitable for topical application, for example emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing the oil phase in solution, gels, solid or pasty anhydrous products, aqueous phases and And / or in the form of a non-ionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray or cone stick. These compositions can also be prepared according to conventional methods in the art. In particular, the composition can be easily prepared in the form of a shampoo, rinse, conditioning, tonic or scalp essence applied to the scalp or hair.

In addition, the composition according to the present invention is a fatty substance, an organic solvent, a dissolving agent, a thickening agent, and a gelling agent. Types, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers And may contain adjuvants commonly used in the cosmetic or dermatological fields, such as wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredient commonly used in cosmetics. . Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.

In addition, in one embodiment of the present invention, the composition may be a medicine. When the composition of the present invention is applied to a pharmaceutical product, by adding the commonly used inorganic or organic carrier using the skate extract as an active ingredient, it can be used as a parenteral agent (transdermal administration or external application) in solid, semi-solid or liquid form. It may be formulated. Formulations for parenteral administration include ointments, lotions, sprays or suspensions. The composition according to the present invention may be formulated according to methods conventionally used in the art, and surfactants, excipients, coloring agents, spices, preservatives, stabilizers, buffers, suspending agents or other compatible adjuvants may be suitably used.

In the case of oral dosage forms, the compositions of the present invention may be used in a known manner using pharmaceutically acceptable carriers and excipients, for example, tablets, troches, sugar-containing tablets, aqueous or oily suspensions, dispersible. Formulated in the form of powder or particles, emulsions, soft or hard capsules, syrups or elixirs, which can be prepared in unit dosage form and in multi-dose containers to produce the finished product.

Oral formulations and tablets include inert diluents such as calcium carbonate, sodium carbonate, lactose, calcium phosphate and sodium phosphate; Granulating agents such as corn, starch and alginic acid; Disintegrants; Binders such as starch, gelatin and acacia; And lubricants such as magnesium stearate, stearic acid, and talc, and the like, and can be prepared in a state compatible with excipients usable for the manufacture of tablets. Tablets can be used uncoated or coated to inhibit absorption and degradation of the tablets in the gastrointestinal tract. For example, time inhibiting substances such as glyceryl monostearate and glyceryl distearate may be applied. Hard kappel is a mixture of the skates of the present invention inert solid diluents such as calcium carbonate, calcium phosphate and kaolin, and soft capsules are water or compatible polypropylene glycol, PEGs (polyethylene glycol) and ethanol, etc. The active ingredient is mixed with solvents and oil solvents such as peanut oil, liquid paraffin and olive oil. A water-soluble suspending agent is a mixture of excipients and active ingredients suitable for preparing a water-soluble suspending agent, and examples of the excipient include, for example, sodium carboxymethyl cellulose, methyl cell, loose, hydroxy-propylmethyl cell. Suspending agents such as osmotic, sodium alginate, polyvinyl-pyridone, gum tragacanth and gum acacia; Compounds condensed with fatty acids such as polyoxystyrene stearate and alkylene oxides; Compounds in which alkylene oxides are condensed with long fatty acids such as heptadecaethyleneoxycetanol; Compounds condensed with ethylene oxide with partial esters derived from hexitol anhydride and fatty acids, such as polyoxyethylene sorbitol monooleate; Wetting agents; Or dispersant spout. The water-soluble suspending agent may further contain preservatives, colorants, spices and sweeteners.

Oil-based suspensions are those obtained by suspending the active ingredient in vegetable oils such as olive oil, sesami oil, or mineral oils such as liquid paraffin. For example, thickening agents such as beeswax, hardened paraffin and cetyl alcohol ( thickening agent). It may also contain preservatives, colorants, spices and sweeteners, which can be preserved by adding antioxidants such as vitamin C.

Dispersible powders and particles contain the active ingredient in a state in which a dispersing agent, a wetting agent, a suspending agent and a preservative are added and mixed together. Suitable dispersing agents, wetting agents or suspending agents can be mentioned as mentioned above. Additional excipients include, for example, sweeteners, spices and colorants.

Oil-based emulsions are made from vegetable oils such as olive oil or mineral oils such as liquid paraffin, and natural phospholipids such as soy bean lecithin, anhydrous hesities such as sorbitan monooleate or fatty acids. Derived from esters, emulsifying the active ingredient with compounds condensed with ethylene oxide with partial esters derived from hexitol anhydride and fatty acids, such as lyoxyethylene sorbitol monooleate Etc.

Syrups and elixirs can be prepared by mixing the active ingredients with sweeteners such as glycerol, propylene glycol, sorbitol and sucrose.

The dosage of the composition according to the present invention may vary depending on the age, sex, weight, the specific disease or condition to be treated, the severity of the disease or pathology, the route of administration and the judgment of the prescriber. Dosage determination based on these factors is within the level of one of ordinary skill in the art and can be applied at the level of one of skill in the art by external application to areas where white hair has developed or has back pain. Typically dosage is within 0.001 mg / kg / day The range is approximately 2000 mg / kg / day. Preferred dosages are 200 // g / kg / day to 5 mg / kg / day.

In addition, the composition according to the present invention can be applied to adhere to the affected area in the form of pars in medicine. In this case, the skate may be formulated into a solid or semi-solid form by adding a commercially available inorganic or organic carrier using the skate extract as an active ingredient.

Compositions according to the present invention having this form of pars may also use auxiliaries used in the field of surfactants, excipients, stabilizers, buffers, alcohols and other pars.

<62>

Hereinafter, the content of the present invention will be described in more detail with reference to Examples and Test Examples. These examples and test examples are presented only for understanding the contents of the present invention, and the scope of the present invention is not limited to these examples and test examples, and modifications, substitutions, and insertions commonly known in the art It can be carried out for this, it is also included in the scope of the present invention.

<64>

Example 1 Preparation of Skate Extract

A distilled smelt distillate was prepared using a smelt-containing distiller.

<67>

<68> [Formulation Example 1]

The cream of Formulation Example 1 was prepared by mixing 80 g of the skate oil extract prepared in Example 1 with 4 g of emulsion wax.

<70>

Test Example 1 Effect of White Hair Treatment

The cream prepared in Formulation Example 1 was applied to the scalp and forehead of the subject in which white hair was generated three to five times a day for 1 week. Then, when the toxins inherent in the application site were red, the process of repeatedly rinsing with warm water was performed for a week, and then pictures of the scalp and hair were shown in FIGS. La to lc.

In the results of la to lc, after applying the cream of Formulation Example 1, it was confirmed that white hair was changed to black hair while the toxins contained in each application site were removed. Therefore, it was found that the skate extract according to the present invention can treat white hair caused by toxins in the body.

<74>

[Test Example 2] Toxin Release Effect The cream prepared in Formulation Example 1 was applied to the subject's scalp three to five times a day for one week. Then, when the toxins inherent in the application site were red, the process of repeatedly rinsing with warm water was performed for a week, and photographs of the face, arms, and legs were shown in FIGS. 2A to 2B and 2C, respectively.

After the application of cream in Figure lc through a series of steps 2a to 2b, it was confirmed that the toxins are discharged to the inside of the foot and the outside of the arm as a result of the sweat rises.

In addition, it was confirmed that black spots on the right side of the face disappeared from the result of FIG. 3A, and in the result of FIG. 3B, acne appeared within 30 minutes after the application of Formulation Example 1, and the knee coated with Formulation Example 1 in the result of FIG. 3C. It was confirmed that the toxins in the skin were discharged in the form of red spots on the site.

[Test Example ₃ ] back pain relief effect

4A and 4B are photographs taken of the waist area by applying the cream prepared in Formulation Example 1 three to five times a day to the waist area of the subject complaining back pain.

In the results of Figures 4a and 4b, it was confirmed that the toxins that were inherent in the skin in the form of red blot on the waist portion coated with the cream of Formulation Example 1 according to the present invention was discharged, and the back pain was also alleviated. As described above, when the skate extract according to the present invention is applied, the toxins in the body are mostly discharged to the outside and the toxins in the skin are red and detoxified.

Example 2 Preparation of Skate Distillate

First step: Smelt is fermented at room temperature (about 15-25 ^° C) for 1 to 20 days.

Extract is obtained using the fermented skates by step 1.

There are three ways to get this extract.

1st eye: The skate which fermented in the said 1st step is contained in a container, and an extract is obtained.

2nd eye: The shimmered fermentation by the said 1st step is put into a container, and an extract is obtained using steam distillation.

Third proposal: Put the smelt fermented in the first step in a distillation to distill the extract 1 gets

<93>

<Test Example 4> Taking and Treatment Effects

The inventors referred to the normal value of heat poisoning in the human body as zero.

On the other hand, it is assumed that the value of the heat poison in the cold body is -1 and the exotherm of the skate distillate is +1.

<97>

When the skate distillate according to the second embodiment of the present invention is taken, it generates heat while colliding with heat poisoning in the human body. As defined above, when taken in the body (-1 state) (+ 1 effect) can be recovered to normal value.

<99>

<ιοο> In addition, when taking the distillate of the present invention at 0, the normal value of heat poisoning is +1 while hitting the body temperature of the human body.

<ιοι> In the +1 state, inflammation in the gums is released to the outside, thereby allowing pain relief and treatment.

In addition, in the +1 state, the skin disease is discharged to the surface of the skin and treated. In this case, the application of the skate oil extract composition according to the present invention in the affected part can be confirmed that the treatment period is shortened and the effect is increased.

The heat poison inherent in a large loss of physical strength is red within 3 to 4 days by applying to the area, in which case the value becomes +1.

<104> In this state, taking the skate oil extract becomes +2 and recovers and is cured.

On the other hand, the numerical value is not described by the inventors as an objective scientific basis for the protection of the numerical value itself, and the criteria are set for easy explanation of the theory of the present invention.

Figure 5 is a picture confirming that gum inflammation is treated according to the use of the skates according to the present invention.

As described above, when taking the distillate of the sauerkraut according to the present invention it can be seen that the inflammation of the gums of the user is treated.

<108>

<109> [Formulation Example 2] Cream

<ιιο> according to the composition of Table 1 to prepare a cream of Formulation Example 2 in a conventional manner ( Unit: weight

Table 1

<112>

<113> [Formulation Example 3] Ointment

<ιΐ4> The ointment of Formulation Example 3 was prepared in a conventional manner according to the composition of Table 2 below (unit: weight%).

<115> [Table 2]

<116>

[Formulation Example 4] Nutrition Cream

The nutritive cream of Formulation Example 4 was prepared in a conventional manner according to the composition of Table 3 below (unit: weight ¾).

<119> [Table 3] Ingredient Formulation Example 1

Skate Extract of Example 1 15

Beeswax 10

Poly ^ bait 60 1.5

Sebum 60 Cured Castor Oil 2

Somvitasesquioleate 0.5

Liquid Parafiber 10

Scuamah 5

Capriric / Capric Triglycerides 5

Glycerin 5

Bug Team Recall 3

Pro ¾ Deposit Recall 3

Triethanolamine 0.2

antiseptic. Correct amount of pigment and flavor

Purified water level

<120>

<121> [Formulation Example 5] Shampoo

To the shampoo of Formulation Example 5 was prepared in a conventional manner according to the composition of Table 4 (unit: weight%).

<123> [Table 4]

<124>

Formulation Example 6 Preparation of Soft Capsule

<126> The skate oil extract of Example 1 264 mg, vitamin E 30 mg, vitamin C 30 mg, palm oil 6 mg, vegetable hardened oil 27 mg, beeswax 13 mg and lecithin 30 mg are mixed and mixed according to a conventional method and soft Capsule layered fluid was prepared. 400 mg per capsule was filled to prepare a soft capsule. In addition, a soft capsule sheet is prepared in 24 wt% of gelatin 66 wt% glycerin and 10 wt% of sorbbi separately from the above, and the stratified solution is laminated in the present invention. A soft capsule containing 400 mg of the composition was prepared.

<127>

Formulation Example 7 Preparation of Tablet

80 mg of skate oil extract of Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 200 mg of galacto-oligosaccharide, 60 mg of lactose and 140 mg of maltose were granulated using a fluidized bed dryer and then sugar ester ( 6 mg of sugar ester) was added. Tablets were prepared by compression of 504 mg of these compositions in a conventional manner.

<130>

Formulation Example 8 Preparation of Drink

80 mg of skate oil extract of Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 10 g of glucose, 0.6 g of citric acid, and 25 g of liquid oligosaccharide were mixed, and then purified water 300 was added to each bottle 200 ιη. Stratified. After filling the bottle sterilized for 4-5 seconds at 130 ^° C to prepare a beverage.

<133>

Formulation Example 9 Preparation of Granules

80 mg of skate oil extract of Example 1, 9 mg of vitamin E, 9 mg of vitamin C, 250 mg of anhydrous crystalline glucose and 550 mg of starch were mixed, and then formed into granules using a fluidized bed granulator and layered on the foam. Manufactured

Industrial Applicability

Meanwhile, such modified embodiments should not be individually understood from the technical spirit or scope of the present invention, and such modified embodiments should be included within the appended claims of the present invention.

Claims

[Range of request]

[Claim 11

Composition containing the skate extract as an active ingredient.

[Claim 2]

The composition of claim 1, wherein the composition contains a skate oil extract in an amount of 0.001-99% by weight based on the total weight of the composition.

[Claim 3]

The composition of claim 1, wherein the composition is a composition for discharging heat poison.

[Claim 4]

The composition of claim 1, wherein the composition is a composition for treating white hair by heat poisoning.

[Claim 5]

The composition of claim 1, wherein the composition is a composition for alleviating back or knee or shoulder pain due to heat poisoning.

[Claim 6]

The composition of claim 1, wherein the composition is a composition for treating gum disease by heat poisoning.

[Claim 71

The composition of claim 1, wherein the composition is a composition for treating colds caused by skin toxins.

[Claim 8]

The composition of any one of claims 1 to 7, wherein the composition is an oral dosage form.

[Claim 9]

The composition according to any one of claims 1 to 7, wherein the composition is an external preparation for skin.