WO2012047703A3 - Cyclopropyl-spiro-pipéridines utiles comme bloqueurs des canaux sodiques - Google Patents

Cyclopropyl-spiro-pipéridines utiles comme bloqueurs des canaux sodiques Download PDF

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Publication number
WO2012047703A3
WO2012047703A3 PCT/US2011/053817 US2011053817W WO2012047703A3 WO 2012047703 A3 WO2012047703 A3 WO 2012047703A3 US 2011053817 W US2011053817 W US 2011053817W WO 2012047703 A3 WO2012047703 A3 WO 2012047703A3
Authority
WO
WIPO (PCT)
Prior art keywords
spiro
cyclopropyl
disorders
sodium channel
administering
Prior art date
Application number
PCT/US2011/053817
Other languages
English (en)
Other versions
WO2012047703A2 (fr
Inventor
Ginny D. Ho
Deen Tulshian
Charles R. Heap
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of WO2012047703A2 publication Critical patent/WO2012047703A2/fr
Publication of WO2012047703A3 publication Critical patent/WO2012047703A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de cyclopropyl-spiro-pipéridine représentés par les Formules (I)-(III) ou des sels pharmaceutiquement acceptables de ceux-ci, qui sont des bloqueurs des canaux sodiques voltage-dépendants. Les compositions pharmaceutiques comprennent une quantité efficace des présents composés, soit seuls soit en combinaison avec un ou plusieurs autres composés thérapeutiquement actifs, et un support pharmaceutiquement acceptable. Les procédés de traitement des pathologies associées à, ou provoquées par, l'activité des canaux sodiques voltage-dépendants, incluant, par exemple, la douleur aiguë, la douleur chronique, la douleur viscérale, la douleur inflammatoire, la douleur neuropathique, l'épilepsie ou les troubles de l'épilepsie, le syndrome du côlon irritable, la dépression, l'anxiété, les troubles bipolaires, les maladies neurodégénératives, les troubles psychiatriques, la myotonie, l'arythmie, les trouble du mouvement, les pathologies neuroendocrines, l'ataxie, la sclérose en plaques, le syndrome du côlon irritable, l'incontinence, la neuropathie et les acouphènes, comprennent l'administration d'une quantité efficace des présents composés, soit seuls soit en combinaison avec un ou plusieurs autres composés thérapeutiquement actifs. Un procédé d'administration d'anesthésie locale comprend l'administration d'une quantité efficace d'un composé de la présente invention, soit seul soit en combinaison avec un ou plusieurs autres composés thérapeutiquement actifs, et un support pharmaceutiquement acceptable.
PCT/US2011/053817 2010-10-04 2011-09-29 Cyclopropyl-spiro-pipéridines utiles comme bloqueurs des canaux sodiques WO2012047703A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38946310P 2010-10-04 2010-10-04
US61/389,463 2010-10-04

Publications (2)

Publication Number Publication Date
WO2012047703A2 WO2012047703A2 (fr) 2012-04-12
WO2012047703A3 true WO2012047703A3 (fr) 2012-06-28

Family

ID=45928334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/053817 WO2012047703A2 (fr) 2010-10-04 2011-09-29 Cyclopropyl-spiro-pipéridines utiles comme bloqueurs des canaux sodiques

Country Status (1)

Country Link
WO (1) WO2012047703A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014159376A (ja) * 2011-06-17 2014-09-04 Taisho Pharmaceutical Co Ltd アザスピロアルカン化合物
US10562857B2 (en) * 2015-11-12 2020-02-18 Afasci, Inc. Ion channel inhibitory compounds, pharmaceutical formulations, and uses
CN105820120B (zh) * 2016-03-25 2019-01-22 上海博栋化学科技有限公司 具有生物活性的6-氮杂螺[2,5]辛烷类化合物及其制备方法和应用
JP2020526557A (ja) * 2017-07-12 2020-08-31 ヴァンダービルト ユニバーシティー ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
EP3697781B1 (fr) 2017-10-17 2023-06-07 Vanderbilt University Antagonistes du récepteur muscarinique de l'acétylcholine m4
WO2019126559A1 (fr) 2017-12-20 2019-06-27 Vanderbilt University Antagonistes du récepteur muscarinique de l'acétylcholine m4
CN110156674A (zh) * 2018-02-13 2019-08-23 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
WO2022152853A1 (fr) * 2021-01-15 2022-07-21 Glaxosmithkline Intellectual Property Development Limited Antagonistes de mrgx2

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407943A (en) * 1991-06-19 1995-04-18 Pfizer Inc. Azaspiro quinolone antibacterial agents
US20080287479A1 (en) * 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
US20090275523A1 (en) * 2006-06-01 2009-11-05 Sanofi-Aventis Spirocyclic nitriles as protease inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407943A (en) * 1991-06-19 1995-04-18 Pfizer Inc. Azaspiro quinolone antibacterial agents
US20090275523A1 (en) * 2006-06-01 2009-11-05 Sanofi-Aventis Spirocyclic nitriles as protease inhibitors
US20080287479A1 (en) * 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM 16 August 2005 (2005-08-16), retrieved from http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3235339 accession no. CGC00012762 *

Also Published As

Publication number Publication date
WO2012047703A2 (fr) 2012-04-12

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