WO2012036585A8 - Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same - Google Patents

Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same Download PDF

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Publication number
WO2012036585A8
WO2012036585A8 PCT/RU2011/000320 RU2011000320W WO2012036585A8 WO 2012036585 A8 WO2012036585 A8 WO 2012036585A8 RU 2011000320 W RU2011000320 W RU 2011000320W WO 2012036585 A8 WO2012036585 A8 WO 2012036585A8
Authority
WO
WIPO (PCT)
Prior art keywords
silicon dioxide
weight
preparing
parenteral administration
pharmaceutical composition
Prior art date
Application number
PCT/RU2011/000320
Other languages
French (fr)
Russian (ru)
Other versions
WO2012036585A1 (en
Inventor
Виктор Львович ЛИМОНОВ
Константин Валентинович ГАЙДУЛЬ
Александр Валерьевич ДУШКИН
Original Assignee
Limonov Viktor Lvovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Limonov Viktor Lvovich filed Critical Limonov Viktor Lvovich
Priority to UAA201203809A priority Critical patent/UA103118C2/en
Priority to CN2011800044095A priority patent/CN103096896A/en
Priority to AU2011302724A priority patent/AU2011302724C1/en
Priority to NZ598831A priority patent/NZ598831A/en
Priority to EP11825509.0A priority patent/EP2620152A4/en
Priority to MX2012010535A priority patent/MX2012010535A/en
Priority to CA2785228A priority patent/CA2785228A1/en
Priority to US13/390,151 priority patent/US20130164337A1/en
Priority to JP2013528146A priority patent/JP2013537190A/en
Priority to BR112012023964A priority patent/BR112012023964A2/en
Publication of WO2012036585A1 publication Critical patent/WO2012036585A1/en
Publication of WO2012036585A8 publication Critical patent/WO2012036585A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antimicrobial preparations for parenteral administration which have increased therapeutic effectiveness in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical compositions comprise, as active ingredient, beta-lactam antibiotics and highly disperse nanostructured silicon dioxide in ratios of from 10:1 to 75:1 by weight, respectively. The silicon dioxide particles present in the composition are the means of supplying the molecules of the antibiotics to the phagocytes, which makes it possible to increase, in a targeted manner, the concentration of the antimicrobial preparations in the areas of inflammation and to substantially neutralize the phenomenon of antibiotic resistance of microorganisms. The claimed process for preparing a pharmaceutical composition consists in mixing a beta-lactam antibiotic substance with highly disperse nanostructured silicon dioxide and is characterized in that the mixture of the above-mentioned substances in ratios of from 10:1 to 75:1 by weight, respectively, is subjected to mechanical processing by means of impact abrasion until the proportion by weight of the finely disperse fraction (< 5 µm) is increased to at least 25%. The resultant mixture is used for preparing injection solutions.
PCT/RU2011/000320 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same WO2012036585A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
UAA201203809A UA103118C2 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
CN2011800044095A CN103096896A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
AU2011302724A AU2011302724C1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
NZ598831A NZ598831A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
EP11825509.0A EP2620152A4 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
MX2012010535A MX2012010535A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same.
CA2785228A CA2785228A1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
US13/390,151 US20130164337A1 (en) 2010-09-13 2011-05-11 Antimicrobial action pharmaceutical composition for parenteral administration and its production process
JP2013528146A JP2013537190A (en) 2010-09-13 2011-05-11 Pharmaceutical composition having antibacterial action for parenteral administration and method for producing the same
BR112012023964A BR112012023964A2 (en) 2010-09-13 2011-05-11 antimicrobial pharmaceutical composition for parenteral administration and production process

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EA201001449 2010-09-13
RU201001449 2010-09-13
EA201001449A EA021874B1 (en) 2010-09-13 2010-09-13 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same

Publications (2)

Publication Number Publication Date
WO2012036585A1 WO2012036585A1 (en) 2012-03-22
WO2012036585A8 true WO2012036585A8 (en) 2012-10-04

Family

ID=45908207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2011/000320 WO2012036585A1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same

Country Status (9)

Country Link
JP (1) JP2013537190A (en)
CN (1) CN103096896A (en)
AU (1) AU2011302724C1 (en)
BR (1) BR112012023964A2 (en)
CA (1) CA2785228A1 (en)
EA (1) EA021874B1 (en)
MX (1) MX2012010535A (en)
NZ (1) NZ598831A (en)
WO (1) WO2012036585A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040058360A (en) * 1996-02-29 2004-07-03 후지사와 야꾸힝 고교 가부시키가이샤 A synthetic sweetener
JP2010500340A (en) * 2006-08-11 2010-01-07 パナセア バイオテック リミテッド Particles for delivering active ingredients, methods for their production and compositions
RU2377985C2 (en) 2006-12-25 2010-01-10 Сергей Михайлович Юдин Preparation for treating infectious diseases caused by multiresistant bacteria

Also Published As

Publication number Publication date
WO2012036585A1 (en) 2012-03-22
NZ598831A (en) 2013-11-29
AU2011302724C1 (en) 2012-11-29
BR112012023964A2 (en) 2016-08-02
CA2785228A1 (en) 2012-03-22
CN103096896A (en) 2013-05-08
AU2011302724B2 (en) 2012-06-28
AU2011302724A1 (en) 2012-05-03
MX2012010535A (en) 2012-11-16
EA021874B1 (en) 2015-09-30
JP2013537190A (en) 2013-09-30
EA201001449A1 (en) 2012-02-28

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