EA201100735A1 - PHARMACEUTICAL COMPOSITION OF ANTIBACTERIAL ACTION FOR PARENTERAL APPLICATION, METHOD OF ITS RECEIVING - Google Patents

PHARMACEUTICAL COMPOSITION OF ANTIBACTERIAL ACTION FOR PARENTERAL APPLICATION, METHOD OF ITS RECEIVING

Info

Publication number
EA201100735A1
EA201100735A1 EA201100735A EA201100735A EA201100735A1 EA 201100735 A1 EA201100735 A1 EA 201100735A1 EA 201100735 A EA201100735 A EA 201100735A EA 201100735 A EA201100735 A EA 201100735A EA 201100735 A1 EA201100735 A1 EA 201100735A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
phosphomycin
beta
complex
resulting mixture
Prior art date
Application number
EA201100735A
Other languages
Russian (ru)
Other versions
EA021846B1 (en
Inventor
Константин Валентинович ГАЙДУЛЬ
Александр Валерьевич ДУШКИН
Original Assignee
ЛИМОНОВ, Виктор Львович
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЛИМОНОВ, Виктор Львович filed Critical ЛИМОНОВ, Виктор Львович
Priority to EA201100735A priority Critical patent/EA021846B1/en
Priority to PCT/RU2011/000779 priority patent/WO2012154076A1/en
Publication of EA201100735A1 publication Critical patent/EA201100735A1/en
Publication of EA021846B1 publication Critical patent/EA021846B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Изобретение относится к фармакологии, медицине, ветеринарии и к фармацевтической промышленности, в частности к способу получения оригинальных композитных антибактериальных препаратов для парентерального применения, которые обладают повышенной терапевтической эффективностью при лечении тяжёлых форм инфекционно-воспалительных заболеваний. Предложенная фармацевтическая композиция содержит в качестве действующего вещества комплекс (бета-лактамный антибиотик+фосфомицин) и высокодисперсный наноструктурированный диоксид кремния. Заявляемый способ получения фармацевтической композиции заключается в смешивании комплекса (бета-лактамный антибиотик+фосфомицин) с высокодисперсным наноструктурированным диоксидом кремния в весовом соотношении от 10:1 до 75:1 по весу соответственно, а полученную смесь подвергают механической обработке путем ударно-истирающих воздействий для увеличения доли мелкодисперсной фракции. Полученную смесь используют для приготовления инъекционных растворов.The invention relates to pharmacology, medicine, veterinary medicine and the pharmaceutical industry, in particular to a method for producing original composite antibacterial preparations for parenteral use, which have increased therapeutic efficacy in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical composition contains as an active ingredient a complex (beta-lactam antibiotic + phosphomycin) and highly dispersed nanostructured silicon dioxide. The inventive method of obtaining a pharmaceutical composition consists in mixing a complex (beta-lactam antibiotic + phosphomycin) with highly dispersed nanostructured silicon dioxide in a weight ratio of 10: 1 to 75: 1 by weight, respectively, and the resulting mixture is subjected to mechanical treatment by impact-abrasion to increase fraction of finely divided fraction. The resulting mixture is used for the preparation of injection solutions.

EA201100735A 2011-05-11 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral use, process for preparing same EA021846B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA201100735A EA021846B1 (en) 2011-05-11 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral use, process for preparing same
PCT/RU2011/000779 WO2012154076A1 (en) 2011-05-11 2011-10-05 Antibacterially active pharmaceutical composition for parenteral use, and method for producing said composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201100735A EA021846B1 (en) 2011-05-11 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral use, process for preparing same

Publications (2)

Publication Number Publication Date
EA201100735A1 true EA201100735A1 (en) 2012-12-28
EA021846B1 EA021846B1 (en) 2015-09-30

Family

ID=47139395

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100735A EA021846B1 (en) 2011-05-11 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral use, process for preparing same

Country Status (2)

Country Link
EA (1) EA021846B1 (en)
WO (1) WO2012154076A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20150199A1 (en) 2012-06-29 2015-01-31 Bayer Animal Health Gmbh PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF MASTITIS
CN103230459A (en) * 2013-04-19 2013-08-07 成进学 Sole acupoint plaster
GB202213753D0 (en) * 2022-09-20 2022-11-02 Helperby Therapeutics Ltd Antimicrobial combinations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169431A (en) * 1984-02-14 1985-09-02 Nippon Zenyaku Kogyo Kk Stable antibacterial agent containing compound having beta-lactam ring and its preparation
ATE424811T1 (en) * 2000-08-31 2009-03-15 Jagotec Ag GROUND PARTICLES
EA013864B1 (en) * 2008-08-29 2010-08-30 Лимонова, Анастасия Викторовна Method of enhancement antimicrobal activity of cephalosporin antibiotics

Also Published As

Publication number Publication date
WO2012154076A1 (en) 2012-11-15
EA021846B1 (en) 2015-09-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU