EA201390626A1 - DERIVATIVES OF HYDROXAMIC ACID AND APPLICATION OF INDICATED DERIVATIVES IN THE TREATMENT OF BACTERIAL INFECTIONS - Google Patents

DERIVATIVES OF HYDROXAMIC ACID AND APPLICATION OF INDICATED DERIVATIVES IN THE TREATMENT OF BACTERIAL INFECTIONS

Info

Publication number
EA201390626A1
EA201390626A1 EA201390626A EA201390626A EA201390626A1 EA 201390626 A1 EA201390626 A1 EA 201390626A1 EA 201390626 A EA201390626 A EA 201390626A EA 201390626 A EA201390626 A EA 201390626A EA 201390626 A1 EA201390626 A1 EA 201390626A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
bacterial infections
treatment
application
hydroxamic acid
Prior art date
Application number
EA201390626A
Other languages
Russian (ru)
Inventor
Рамеш Касар
Мартин Шерингэм Линселл
Джеймс Брэдли Эгжен
Цин Лу (Джейн)
Дэн Ван
Тим Черч
Хейнц Э. Моузер
Филип А. Пэттен
Original Assignee
Эйкеоджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйкеоджен, Инк. filed Critical Эйкеоджен, Инк.
Publication of EA201390626A1 publication Critical patent/EA201390626A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Предложены антибактериальные соединения формулы I, а также их стереоизомеры и фармацевтически приемлемые соли; фармацевтические композиции, включающие такие соединения; способы лечения бактериальных инфекций путем введения указанных соединений; применение соединений в лечении бактериальных инфекций и способы получения указанных соединений.Antibacterial compounds of the formula I are provided, as well as their stereoisomers and pharmaceutically acceptable salts; pharmaceutical compositions comprising such compounds; methods for treating bacterial infections by administering said compounds; the use of compounds in the treatment of bacterial infections and methods for producing these compounds.

EA201390626A 2010-11-10 2011-11-04 DERIVATIVES OF HYDROXAMIC ACID AND APPLICATION OF INDICATED DERIVATIVES IN THE TREATMENT OF BACTERIAL INFECTIONS EA201390626A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
EA201390626A1 true EA201390626A1 (en) 2013-12-30

Family

ID=46317476

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390626A EA201390626A1 (en) 2010-11-10 2011-11-04 DERIVATIVES OF HYDROXAMIC ACID AND APPLICATION OF INDICATED DERIVATIVES IN THE TREATMENT OF BACTERIAL INFECTIONS

Country Status (14)

Country Link
EP (1) EP2638006A1 (en)
JP (1) JP2014501716A (en)
KR (1) KR20140023869A (en)
CN (1) CN103298780A (en)
AR (1) AR083760A1 (en)
AU (1) AU2011367819A1 (en)
BR (1) BR112013011693A2 (en)
CA (1) CA2817211A1 (en)
EA (1) EA201390626A1 (en)
IL (1) IL226270A0 (en)
MX (1) MX2013005200A (en)
SG (1) SG190243A1 (en)
TW (1) TW201249786A (en)
WO (1) WO2012154204A1 (en)

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JP5539864B2 (en) 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド Antibacterial agent
WO2013170030A1 (en) * 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
AR097617A1 (en) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd ANTIBACTERIAL DERIVATIVES OF 2H-INDAZOL
MA39189A1 (en) 2013-12-19 2017-06-30 Actelion Pharmaceuticals Ltd Derivatives of 1h-indazole and 1h-indole antibacterials
AR099612A1 (en) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd ANTIBACTERIAL DERIVATIVES OF 1,2-DIHIDRO-3H-PIRROLO [1,2-C] IMIDAZOL-3-ONA
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
EP3143007B1 (en) 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
WO2016079688A1 (en) 2014-11-19 2016-05-26 Actelion Pharmaceuticals Ltd Antibacterial benzothiazole derivatives
CA2969803A1 (en) 2014-12-16 2016-06-23 Novartis Ag Isoxazole hydroxamic acid compounds as lpxc inhibitors
US11034649B2 (en) 2016-04-25 2021-06-15 Duke University Benzoylglycine derivatives and methods of making and using same
HUE050796T2 (en) 2016-06-14 2021-01-28 Novartis Ag Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
CN112074507B (en) * 2018-02-10 2023-09-05 山东亨利医药科技有限责任公司 Compounds as Antibiotics
CN110563611B (en) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 Hydroxamic acid derivative and preparation method and application thereof
CN113957098A (en) * 2021-09-13 2022-01-21 湖南工业大学 Application of providencia bacterial strain in preparation of divalent manganese oxidant
CN116730870B (en) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 Hydroxamic acid compound or pharmaceutically acceptable salt thereof, application and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AU3979200A (en) 1999-04-09 2000-11-14 British Biotech Pharmaceuticals Limited Antimicrobial agents
KR101076018B1 (en) * 2003-01-08 2011-10-21 유니버시티 오브 워싱톤 Antibacterial agents
DE102006032709A1 (en) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Airborne food mill
CN101209974A (en) * 2006-12-31 2008-07-02 天津药物研究院 Hydroxamic acids derivatives and use thereof
JP5539864B2 (en) 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド Antibacterial agent
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
HUE044575T2 (en) * 2010-04-20 2019-11-28 Fujifilm Toyama Chemical Co Ltd Hydroxamic acid derivative

Also Published As

Publication number Publication date
KR20140023869A (en) 2014-02-27
CN103298780A (en) 2013-09-11
WO2012154204A1 (en) 2012-11-15
MX2013005200A (en) 2013-06-28
AU2011367819A1 (en) 2013-05-02
IL226270A0 (en) 2013-07-31
BR112013011693A2 (en) 2016-08-09
JP2014501716A (en) 2014-01-23
EP2638006A1 (en) 2013-09-18
SG190243A1 (en) 2013-06-28
AR083760A1 (en) 2013-03-20
CA2817211A1 (en) 2012-11-15
TW201249786A (en) 2012-12-16

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