EA201001449A1 - PHARMACEUTICAL COMPOSITION OF ANTIMICROBIAL ACTION FOR PARENTERAL ADMINISTRATION AND METHOD FOR ITS OBTAINING - Google Patents

PHARMACEUTICAL COMPOSITION OF ANTIMICROBIAL ACTION FOR PARENTERAL ADMINISTRATION AND METHOD FOR ITS OBTAINING

Info

Publication number
EA201001449A1
EA201001449A1 EA201001449A EA201001449A EA201001449A1 EA 201001449 A1 EA201001449 A1 EA 201001449A1 EA 201001449 A EA201001449 A EA 201001449A EA 201001449 A EA201001449 A EA 201001449A EA 201001449 A1 EA201001449 A1 EA 201001449A1
Authority
EA
Eurasian Patent Office
Prior art keywords
silicon dioxide
weight
obtaining
pharmaceutical composition
ratios
Prior art date
Application number
EA201001449A
Other languages
Russian (ru)
Other versions
EA021874B1 (en
Inventor
Константин Валентинович ГАЙДУЛЬ
Александр Валерьевич ДУШКИН
Original Assignee
ЛИМОНОВ, Виктор Львович
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЛИМОНОВ, Виктор Львович filed Critical ЛИМОНОВ, Виктор Львович
Priority to EA201001449A priority Critical patent/EA021874B1/en
Priority to BR112012023964A priority patent/BR112012023964A2/en
Priority to NZ598831A priority patent/NZ598831A/en
Priority to CN2011800044095A priority patent/CN103096896A/en
Priority to MX2012010535A priority patent/MX2012010535A/en
Priority to CA2785228A priority patent/CA2785228A1/en
Priority to JP2013528146A priority patent/JP2013537190A/en
Priority to PCT/RU2011/000320 priority patent/WO2012036585A1/en
Priority to AU2011302724A priority patent/AU2011302724C1/en
Publication of EA201001449A1 publication Critical patent/EA201001449A1/en
Publication of EA021874B1 publication Critical patent/EA021874B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к фармакологии, медицине, ветеринарии и к фармацевтической промышленности, в частности к способу получения оригинальных композитных антимикробных препаратов для парентерального применения, которые обладают повышенной терапевтической эффективностью при лечении тяжёлых форм инфекционно-воспалительных заболеваний. Предложенные фармацевтические композиции содержат в качестве действующего вещества бета-лактамные антибиотики и высокодисперсный наноструктурированный диоксид кремния в соотношениях от 10:1 до 75:1 по весу соответственно. Присутствующие в композиции частицы диоксида кремния являются средствами доставки молекул антибиотиков в фагоциты, что позволяет целенаправленно повышать концентрацию антимикробных препаратов в зонах воспаления и существенно нивелировать феномен антибиотикорезистентности микроорганизмов. Заявляемый способ получения фармацевтической композиции заключается в смешивании субстанции бета-лактамного антибиотика с высокодисперсным наноструктурированным диоксидом кремния, отличающийся тем, что смесь вышеуказанных веществ в соотношениях от 10:1 до 75:1 по весу соответственно подвергают механической обработке путем ударно-истирающих воздействий до увеличения весовой доли мелкодисперсной фракции (< 5 мкм) не менее чем до 25%. Полученную смесь используют для приготовления инъекционных растворов.The invention relates to pharmacology, medicine, veterinary medicine and the pharmaceutical industry, in particular to a method for producing original composite antimicrobial preparations for parenteral use, which have increased therapeutic efficacy in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical compositions contain beta-lactam antibiotics and highly dispersed nanostructured silicon dioxide as active substance in ratios of 10: 1 to 75: 1 by weight, respectively. The particles of silicon dioxide present in the composition are means of delivering antibiotic molecules to phagocytes, which makes it possible to purposefully increase the concentration of antimicrobial agents in inflammation zones and significantly level the phenomenon of antibiotic resistance of microorganisms. The inventive method of obtaining a pharmaceutical composition consists in mixing a beta-lactam antibiotic substance with highly dispersed nanostructured silicon dioxide, characterized in that the mixture of the above substances in ratios from 10: 1 to 75: 1 by weight, respectively, is subjected to mechanical treatment by impact-abrasion to increase the weight fraction of finely divided fraction (<5 μm) not less than 25%. The resulting mixture is used for the preparation of injection solutions.

EA201001449A 2010-09-13 2010-09-13 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same EA021874B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EA201001449A EA021874B1 (en) 2010-09-13 2010-09-13 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
BR112012023964A BR112012023964A2 (en) 2010-09-13 2011-05-11 antimicrobial pharmaceutical composition for parenteral administration and production process
NZ598831A NZ598831A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
CN2011800044095A CN103096896A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
MX2012010535A MX2012010535A (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same.
CA2785228A CA2785228A1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
JP2013528146A JP2013537190A (en) 2010-09-13 2011-05-11 Pharmaceutical composition having antibacterial action for parenteral administration and method for producing the same
PCT/RU2011/000320 WO2012036585A1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same
AU2011302724A AU2011302724C1 (en) 2010-09-13 2011-05-11 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201001449A EA021874B1 (en) 2010-09-13 2010-09-13 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same

Publications (2)

Publication Number Publication Date
EA201001449A1 true EA201001449A1 (en) 2012-02-28
EA021874B1 EA021874B1 (en) 2015-09-30

Family

ID=45908207

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001449A EA021874B1 (en) 2010-09-13 2010-09-13 Pharmaceutical composition with antimicrobial activity for parenteral administration and process for preparing same

Country Status (9)

Country Link
JP (1) JP2013537190A (en)
CN (1) CN103096896A (en)
AU (1) AU2011302724C1 (en)
BR (1) BR112012023964A2 (en)
CA (1) CA2785228A1 (en)
EA (1) EA021874B1 (en)
MX (1) MX2012010535A (en)
NZ (1) NZ598831A (en)
WO (1) WO2012036585A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0890359B1 (en) * 1996-02-29 2002-05-02 Fujisawa Pharmaceutical Co., Ltd. Tablets containing beta-lactam antibiotic and process for producing the same
BRPI0716658A2 (en) * 2006-08-11 2015-02-10 Panacea Biotec Ltd PARTICULARS FOR DISTRIBUTION OF ACTIVE INGREDIENTS, MANUFACTURING PROCESS AND COMPOSITIONS
RU2377985C2 (en) 2006-12-25 2010-01-10 Сергей Михайлович Юдин Preparation for treating infectious diseases caused by multiresistant bacteria

Also Published As

Publication number Publication date
NZ598831A (en) 2013-11-29
CN103096896A (en) 2013-05-08
WO2012036585A8 (en) 2012-10-04
JP2013537190A (en) 2013-09-30
MX2012010535A (en) 2012-11-16
EA021874B1 (en) 2015-09-30
CA2785228A1 (en) 2012-03-22
BR112012023964A2 (en) 2016-08-02
AU2011302724A1 (en) 2012-05-03
AU2011302724C1 (en) 2012-11-29
WO2012036585A1 (en) 2012-03-22
AU2011302724B2 (en) 2012-06-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU