WO2012029957A1 - Procédé pour créer un animal cloné - Google Patents

Procédé pour créer un animal cloné Download PDF

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Publication number
WO2012029957A1
WO2012029957A1 PCT/JP2011/070062 JP2011070062W WO2012029957A1 WO 2012029957 A1 WO2012029957 A1 WO 2012029957A1 JP 2011070062 W JP2011070062 W JP 2011070062W WO 2012029957 A1 WO2012029957 A1 WO 2012029957A1
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WO
WIPO (PCT)
Prior art keywords
xist
embryos
expression
gene
chromosome
Prior art date
Application number
PCT/JP2011/070062
Other languages
English (en)
Japanese (ja)
Inventor
淳郎 小倉
貴美子 井上
史敏 石野
尚 幸田
澤井　健
Original Assignee
独立行政法人理化学研究所
国立大学法人東京医科歯科大学
国立大学法人岩手大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 独立行政法人理化学研究所, 国立大学法人東京医科歯科大学, 国立大学法人岩手大学 filed Critical 独立行政法人理化学研究所
Publication of WO2012029957A1 publication Critical patent/WO2012029957A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0273—Cloned animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne la découverte selon laquelle le modèle d'expression du gène dans un embryon reconstruit obtenu au moyen du transfert nucléaire de cellule somatique normalisé en délétant le Xist fonctionne sur le chromosome X actif de l'embryon reconstruit, améliorant de cette façon l'efficacité du clonage de 7 à 8 fois.
PCT/JP2011/070062 2010-09-03 2011-09-02 Procédé pour créer un animal cloné WO2012029957A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010197583 2010-09-03
JP2010-197583 2010-09-03

Publications (1)

Publication Number Publication Date
WO2012029957A1 true WO2012029957A1 (fr) 2012-03-08

Family

ID=45773031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2011/070062 WO2012029957A1 (fr) 2010-09-03 2011-09-02 Procédé pour créer un animal cloné

Country Status (1)

Country Link
WO (1) WO2012029957A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510220A (ja) * 2013-02-15 2016-04-07 ソン クヮン メデイカル ファウンデーション 体細胞核移植を利用する単為生殖幹細胞および患者特異的ヒト胚幹細胞の製造法
WO2020018106A1 (fr) * 2018-07-19 2020-01-23 Children's Medical Center Corporation Compositions et procédés pour générer une inactivation du chromosome x physiologique
CN111849866A (zh) * 2020-07-15 2020-10-30 华南农业大学 H3K27me3调控FoxO1基因表达在猪卵巢颗粒细胞中的应用
JP2021514199A (ja) * 2018-01-17 2021-06-10 センター フォー エクセレンス イン ブレイン サイエンス アンド インテリジェンス テクノロジー，チャイニーズ アカデミー オブ サイエンシーズＣｅｎｔｅｒ Ｆｏｒ Ｅｘｃｅｌｌｅｎｃｅ Ｉｎ Ｂｒａｉｎ Ｓｃｉｅｎｃｅ Ａｎｄ Ｉｎｔｅｌｌｉｇｅｎｃｅ Ｔｅｃｈｎｏｌｏｇｙ，Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ Ｏｆ Ｓｃｉｅｎｃｅｓ 非ヒト霊長類の体細胞クローン動物の製造方法
US20210340493A1 (en) * 2018-08-01 2021-11-04 University Of Georgia Research Foundation, Inc. Compositions and methods for improving embryo development
US11390885B2 (en) 2014-09-15 2022-07-19 Children's Medical Center Corporation Methods and compositions to increase somatic cell nuclear transfer (SCNT) efficiency by removing histone H3-lysine trimethylation
US11535824B2 (en) 2015-10-29 2022-12-27 Sung Kwang Medical Foundation Nuclear transfer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005245294A (ja) * 2004-03-03 2005-09-15 Nipro Corp 体外操作胚の正常性の判定又はスクリーニング方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005245294A (ja) * 2004-03-03 2005-09-15 Nipro Corp 体外操作胚の正常性の判定又はスクリーニング方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAO, S ET AL.: "Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte.", EMBO REP., vol. 6, no. 8, August 2005 (2005-08-01), pages 748 - 754 *
INOUE, K ET AL.: "Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.", SCIENCE., vol. 330, no. 6003, 22 October 2010 (2010-10-22), pages 496 - 499 *
KISHIGAMI, S ET AL.: "Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer.", J REPROD DEV., vol. 53, no. 1, February 2007 (2007-02-01), pages 165 - 170 *
NOLEN, LD ET AL.: "X chromosome reactivation and regulation in cloned embryos.", DEV BIOL., vol. 279, no. 2, 15 March 2005 (2005-03-15), pages 525 - 540 *
SHAO, GB ET AL.: "Inheritance of histone H3 methylation in reprogramming of somatic nuclei following nuclear transfer.", J REPROD DEV., vol. 54, no. 3, June 2008 (2008-06-01), pages 233 - 238 *
THUAN, NV ET AL.: "How to improve the success rate of mouse cloning technology.", J REPROD DEV., vol. 56, no. 1, February 2010 (2010-02-01), pages 20 - 30 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510220A (ja) * 2013-02-15 2016-04-07 ソン クヮン メデイカル ファウンデーション 体細胞核移植を利用する単為生殖幹細胞および患者特異的ヒト胚幹細胞の製造法
US10017733B2 (en) 2013-02-15 2018-07-10 Sung Kwang Medical Foundation Production of parthenogenetic stem cells and patient-specific human embryonic stem cells using somatic cell nuclear transfer
US11339369B2 (en) 2013-02-15 2022-05-24 Sung Kwang Medical Foundation Production of parthenogenetic stem cells and patient-specific human embryonic stem cells using somatic cell nuclear transfer
US11390885B2 (en) 2014-09-15 2022-07-19 Children's Medical Center Corporation Methods and compositions to increase somatic cell nuclear transfer (SCNT) efficiency by removing histone H3-lysine trimethylation
US11535824B2 (en) 2015-10-29 2022-12-27 Sung Kwang Medical Foundation Nuclear transfer
JP2021514199A (ja) * 2018-01-17 2021-06-10 センター フォー エクセレンス イン ブレイン サイエンス アンド インテリジェンス テクノロジー，チャイニーズ アカデミー オブ サイエンシーズＣｅｎｔｅｒ Ｆｏｒ Ｅｘｃｅｌｌｅｎｃｅ Ｉｎ Ｂｒａｉｎ Ｓｃｉｅｎｃｅ Ａｎｄ Ｉｎｔｅｌｌｉｇｅｎｃｅ Ｔｅｃｈｎｏｌｏｇｙ，Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ Ｏｆ Ｓｃｉｅｎｃｅｓ 非ヒト霊長類の体細胞クローン動物の製造方法
JP7199741B2 (ja) 2018-01-17 2023-01-06 センター フォー エクセレンス イン ブレイン サイエンス アンド インテリジェンス テクノロジー，チャイニーズ アカデミー オブ サイエンシーズ 非ヒト霊長類の体細胞クローン動物の製造方法
WO2020018106A1 (fr) * 2018-07-19 2020-01-23 Children's Medical Center Corporation Compositions et procédés pour générer une inactivation du chromosome x physiologique
US20210340493A1 (en) * 2018-08-01 2021-11-04 University Of Georgia Research Foundation, Inc. Compositions and methods for improving embryo development
US11939593B2 (en) * 2018-08-01 2024-03-26 University Of Georgia Research Foundation, Inc. Compositions and methods for improving embryo development
CN111849866A (zh) * 2020-07-15 2020-10-30 华南农业大学 H3K27me3调控FoxO1基因表达在猪卵巢颗粒细胞中的应用
CN111849866B (zh) * 2020-07-15 2022-06-24 华南农业大学 H3K27me3调控FoxO1基因表达在猪卵巢颗粒细胞中的应用

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