WO2012025582A3 - Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen - Google Patents

Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen Download PDF

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Publication number
WO2012025582A3
WO2012025582A3 PCT/EP2011/064603 EP2011064603W WO2012025582A3 WO 2012025582 A3 WO2012025582 A3 WO 2012025582A3 EP 2011064603 W EP2011064603 W EP 2011064603W WO 2012025582 A3 WO2012025582 A3 WO 2012025582A3
Authority
WO
WIPO (PCT)
Prior art keywords
self
assembling
producing
electrospinning
highly concentrated
Prior art date
Application number
PCT/EP2011/064603
Other languages
English (en)
French (fr)
Other versions
WO2012025582A2 (de
Inventor
Evgueni Klimov
Burghard Liebmann
Thomas Subkowski
Martin Möller
Doris Klee
Artem Davidenko
Wiebke Voigt
Gunter Scharfenberger
Original Assignee
Basf Se
Freudenberg Forschungsdienste Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se, Freudenberg Forschungsdienste Kg filed Critical Basf Se
Priority to EP11752173.2A priority Critical patent/EP2609109A2/de
Priority to JP2013525306A priority patent/JP2013544754A/ja
Priority to CN201180051094XA priority patent/CN103209991A/zh
Priority to KR1020137007474A priority patent/KR20140048067A/ko
Publication of WO2012025582A2 publication Critical patent/WO2012025582A2/de
Publication of WO2012025582A3 publication Critical patent/WO2012025582A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/0053—Electro-spinning characterised by the initial state of the material the material being a low molecular weight compound or an oligomer, and the fibres being formed by self-assembly
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/15—Proteins or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Textile Engineering (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Polymers & Plastics (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Artificial Filaments (AREA)
  • Nonwoven Fabrics (AREA)

Abstract

Die vorliegende Erfindung betrifft stabile wässrige Proteindispersionen, umfassend in einer wässrigen Phase wenigstens ein selbstassemblierendes Protein in dispergierter Form sowie wenigstens ein spezielles Dispergiermittel für das selbstassemblierende Protein; Verfahren zur Herstellung solcher stabilen wässrigen Dispersionen; Verfahren zur Elektroverspinnung von selbstassemblierenden Proteinen unter Verwendung solcher stabiler wässriger Dispersionen; Verfahren zur Herstellung von Faserflächengebilden oder Fasern aus solchen wässrigen Dispersionen; die Verwendung solcher wässriger Dispersionen zur Beschichtung von Oberflächen; die Verwendung der durch Elektroverspinnung hergestellten Materialien zur Herstellung von Medizinprodukten, Hygieneartikeln und Textilien; sowie Faser- oder Faserflächengebilde, hergestellt nach einem erfindungsgemäßen Elektroverspinnungsverfahren.
PCT/EP2011/064603 2010-08-26 2011-08-25 Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen WO2012025582A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP11752173.2A EP2609109A2 (de) 2010-08-26 2011-08-25 Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen
JP2013525306A JP2013544754A (ja) 2010-08-26 2011-08-25 セルフアッセンブリータンパク質の高濃縮溶液の生産方法
CN201180051094XA CN103209991A (zh) 2010-08-26 2011-08-25 用于产生自组装蛋白质的高浓缩溶液的方法
KR1020137007474A KR20140048067A (ko) 2010-08-26 2011-08-25 자기-조립형 단백질의 고 농축 용액의 제조 방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10174080.1 2010-08-26
EP10174080 2010-08-26

Publications (2)

Publication Number Publication Date
WO2012025582A2 WO2012025582A2 (de) 2012-03-01
WO2012025582A3 true WO2012025582A3 (de) 2012-09-07

Family

ID=44789422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/064603 WO2012025582A2 (de) 2010-08-26 2011-08-25 Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen

Country Status (5)

Country Link
EP (1) EP2609109A2 (de)
JP (1) JP2013544754A (de)
KR (1) KR20140048067A (de)
CN (1) CN103209991A (de)
WO (1) WO2012025582A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109137102B (zh) * 2018-09-30 2020-11-24 吉林大学 一种具有定向疏水的仿蜘蛛丝纤维结构制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10344296B2 (en) 2012-04-05 2019-07-09 Basf Plant Science Company Gmbh Fungal resistant plants expressing hydrophobin
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
US10202636B2 (en) 2013-12-24 2019-02-12 General Electric Company Electrospun fibers for protein stabilization and storage
JP6460675B2 (ja) * 2014-08-04 2019-01-30 国立大学法人信州大学 シルク複合ナノファイバーの製造方法
GB201415681D0 (en) 2014-09-04 2014-10-22 Cambridge Entpr Ltd And President And Fellows Of Harvard College Protien Capsules
CN105951210B (zh) * 2016-06-24 2018-06-19 南通纺织丝绸产业技术研究院 一种珠粒形貌的串珠纤维材料及其制备方法
CN107236999A (zh) * 2017-07-17 2017-10-10 合肥威斯伏新材料有限公司 一种鱼皮胶原自组装成纤维的方法
JPWO2019194249A1 (ja) * 2018-04-03 2021-04-15 Ｓｐｉｂｅｒ株式会社 ドープ液、改変フィブロイン繊維及びその製造方法
WO2021183469A1 (en) * 2020-03-09 2021-09-16 Amprion, Inc. Cerebrospinal fluid assay control solution
CN113106756A (zh) * 2021-03-10 2021-07-13 浙江凯喜雅国际股份有限公司 一种蚕丝蛋白涂层液及其在纤维或织物表面改性中的应用
CN113508863B (zh) * 2021-07-14 2023-04-14 江南大学 一种全溶性食用菌蛋白及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1989005A (en) * 1929-12-23 1935-01-22 Ig Farbenindustrie Ag Solutions of fibroin
JPS6170075A (ja) * 1984-09-12 1986-04-10 水島　繁三郎 形状記憶生糸の製造方法
WO2005012606A2 (en) * 2003-04-10 2005-02-10 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2008155304A1 (de) * 2007-06-20 2008-12-24 Basf Se Synthetische repetitive proteine, deren herstellung und verwendung
WO2010057654A1 (de) * 2008-11-24 2010-05-27 Byk-Chemie Gmbh Zusammensetzungen umfassend glycidylether-copolymere

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4440858A1 (de) 1994-11-15 1996-05-23 Basf Ag Biologisch abbaubare Polymere, Verfahren zu deren Herstellung sowie deren Verwendung zur Herstellung bioabbaubarer Formkörper
AU2003202949A1 (en) 2002-01-11 2003-07-30 Ali Alwattari Methods and apparatus for spinning spider silk protein
CN104856962A (zh) 2006-01-20 2015-08-26 慕尼黑工业大学 两性自组装蛋白质在配制低水溶性的有效物质中的用途
WO2010015709A2 (de) 2008-08-08 2010-02-11 Basf Se Wirkstoffhaltige fasernflächengebilde mit einstellbarer wirkstofffreisetzung, ihre anwendungen und verfahren zu ihrer herstellung
EP2684562A1 (de) 2008-08-08 2014-01-15 Basf Se Wirkstoffhaltige Fasernflächengebilde auf Basis von Biopolymeren, ihre Anwendungen und Verfahren zu ihrer Herstellung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1989005A (en) * 1929-12-23 1935-01-22 Ig Farbenindustrie Ag Solutions of fibroin
JPS6170075A (ja) * 1984-09-12 1986-04-10 水島　繁三郎 形状記憶生糸の製造方法
WO2005012606A2 (en) * 2003-04-10 2005-02-10 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2008155304A1 (de) * 2007-06-20 2008-12-24 Basf Se Synthetische repetitive proteine, deren herstellung und verwendung
WO2010057654A1 (de) * 2008-11-24 2010-05-27 Byk-Chemie Gmbh Zusammensetzungen umfassend glycidylether-copolymere

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CRODA INC: "Use of diester quats for UV protection", RESEARCH DISCLOSURE, MASON PUBLICATIONS, HAMPSHIRE, GB, vol. 535, no. 33, 1 November 2008 (2008-11-01), pages 982, XP007138562, ISSN: 0374-4353 *
FORLANI GIUSEPPE ET AL: "A bacterial extracellular proteinase degrading silk fibroin", INTERNATIONAL BIODETERIORATION AND BIODEGRADATION, vol. 46, no. 4, 2000, pages 271 - 275, XP002666216, ISSN: 0964-8305 *
HUEMMERICH D ET AL: "Primary structure elements of spider dragline silks and their contribution to protein solubility", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43, no. 42, 26 October 2004 (2004-10-26), pages 13604 - 13612, XP002367100, ISSN: 0006-2960, DOI: 10.1021/BI048983Q *
LAZARIS A ET AL: "Spider silk fibers spun from soluble recombinant silk produced in mammalian cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 295, no. 5554, 18 January 2002 (2002-01-18), pages 472 - 476, XP002243786, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1065780 *
LIEBMANN B ET AL: "Formulation of poorly water-soluble substances using self-assembling spider silk protein", COLLOIDS AND SURFACES. A, PHYSICACHEMICAL AND ENGINEERING ASPECTS, ELSEVIER, AMSTERDAM, NL, vol. 331, no. 1-2, 10 December 2008 (2008-12-10), pages 126 - 132, XP025680788, ISSN: 0927-7757, [retrieved on 20080412], DOI: 10.1016/J.COLSURFA.2008.04.005 *
SASHINA E S ET AL: "Structure and solubility of natural silk fibroin", RUSSIAN JOURNAL OF APPLIED CHEMISTRY, NAUKA/INTERPERIODICA, MO, vol. 79, no. 6, 1 June 2006 (2006-06-01), pages 869 - 876, XP019406765, ISSN: 1608-3296, DOI: 10.1134/S1070427206060012 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109137102B (zh) * 2018-09-30 2020-11-24 吉林大学 一种具有定向疏水的仿蜘蛛丝纤维结构制备方法

Also Published As

Publication number Publication date
WO2012025582A2 (de) 2012-03-01
JP2013544754A (ja) 2013-12-19
KR20140048067A (ko) 2014-04-23
CN103209991A (zh) 2013-07-17
EP2609109A2 (de) 2013-07-03

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