WO2012025261A1 - Appareil de thérapie - Google Patents

Appareil de thérapie Download PDF

Info

Publication number
WO2012025261A1
WO2012025261A1 PCT/EP2011/057619 EP2011057619W WO2012025261A1 WO 2012025261 A1 WO2012025261 A1 WO 2012025261A1 EP 2011057619 W EP2011057619 W EP 2011057619W WO 2012025261 A1 WO2012025261 A1 WO 2012025261A1
Authority
WO
WIPO (PCT)
Prior art keywords
electron
accelerator
electron beam
ray
therapy device
Prior art date
Application number
PCT/EP2011/057619
Other languages
German (de)
English (en)
Inventor
Oliver Heid
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Publication of WO2012025261A1 publication Critical patent/WO2012025261A1/fr

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
    • H05H7/02—Circuits or systems for supplying or feeding radio-frequency energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1091—Kilovoltage or orthovoltage range photons

Definitions

  • the invention relates to a combined electron and X-ray therapy device.
  • Such combination therapy devices work either ent ⁇ neither in an operating mode "X-ray” or in an operating mode “electron irradiation”.
  • ⁇ beam is a target volume, eg., A tumor of a patient is irradiated.
  • such a device has a single electron accelerator in the form of a linear accelerator.
  • the electron beam brought to a certain final energy in the accelerator strikes a target in the "X-ray irradiation" operating mode.
  • the electrons of the electron beam are decelerated, resulting in X-ray Bremsstrahlung, which can be used to irradiate the target volume.
  • Behind the target is a collimator for superimposing the X-ray cone on the target volume or for adapting the beam field, i. essentially the cross-sectional shape of the respective beam, to the target volume.
  • electro beam irradiation is the target outside the electron beam path, so that the electrons can impinge on the patient or on the Packaging Target ⁇ lumen unhindered.
  • a collimation as in X-ray mode is usually not used.
  • electron ⁇ ne operation an electron energy of about 20MeV is required ⁇ tigt, for X-ray operation only about 6MeV.
  • the high electron energy for electron irradiation requires a long accelerator, which allows only relatively small beam currents, since, inter alia, with the length of the loading accelerate the loss of electrons of the electron ⁇ beam increases.
  • a short accelerator path allows the generation of a higher beam current al ⁇ so with a constant particle source. Consequently, only a relatively low dose rate is available with simultaneously unnecessarily hard beam spectrum in the X-ray mode because of the relatively long accelerator path .
  • the electrons lost in the long beam tube cause harmful scattered X-radiation.
  • the electron beam is deflected at the accelerator output, so that the accelerator can be arranged substantially parallel to the rotation axis of the system.
  • the necessary for this deflection magnet leads to a significant increase in particular the weight and, to a lesser extent, the dimensions of the radiating head to be pivoted.
  • a combined therapy device which has a combined accelerator device with two ge ⁇ separated accelerators, both of which are alignable isolated on the target volume.
  • One of the accelerators is set up to operate in X-ray mode of Therapy device to generate X-rays.
  • the other accelerator is set up to generate an electron beam in electron beam operation of the combination therapy device.
  • X-ray operation is a first, relatively short accelerator with a strong beam current whose accelerated electron beam is directed to generate the X-ray radiation to the target.
  • an adjustable collimator Between the target and the target volume is an adjustable collimator. The short design allows a high beam current with simultaneously low scattered X-radiation.
  • a second relatively long high energy accelerator is used for electron beam operation. This ensures that the electrons can be accelerated to a sufficient for the intended purpose of energy, so that the penetration depth is suffi ⁇ accordingly high for therapeutic purposes into the tissue to reach the target volume.
  • the two blasting devices are arranged such that the beam fields which can be generated with them are aligned with a working region of the therapy device.
  • the target to be irradiated ⁇ volume is placed in the work area, so that it is coverable by the beam fields of the two beam devices.
  • Beam fields in each position of the jet head are aligned to the work area.
  • the isocenter of the arrangement is therefore in the work area and ideally in the target volume.
  • Both the first and the second accelerator may be radially aligned, ie, the accelerator and the beam tubes or accelerator sections are aligned such that their longitudinal axis and the accelerated electron beam in them substantially to the isocenter of the combination therapy device aims, so that each generated radiation ⁇ ment without the use of a deflection intersects the axis of rotation of the combination therapy device at an angle of about 90 °.
  • the jet pipes or accelerator sections can also be aligned axially, ie largely parallel to the axis of rotation of the combination therapy device.
  • a deflector may be provided.
  • this is a deflection magnet, with which the initially axial orientation of the electron beam is converted into a, for example, radial orientation.
  • the target is arranged such that the X-ray radiation generated in the target by the braking of the accelerated electrons exits the target at the desired angle to the electron beam.
  • a deflection magnet is arranged in the region of the output, which deflects the electrons leaving the accelerator, whereby the required X-ray radiation in the form of Bremsstrahlung is generated.
  • the therapy device thus has a combined accelerator device with which optionally an X-ray field X and / or a
  • E-beam field E can be generated.
  • Accelerator device is located in a jet head of the therapy device.
  • the beam field generated in each case in the operating state can be aligned to a working area of the therapy device.
  • the accelerator device includes
  • the X-ray apparatus comprises a first electron source, particularly an electron gun, a first electron ⁇ accelerator, and a target, wherein the removable of the first electron source, electrons are accelerated to the first electron accelerator in the operating state and the first electron beam thus generated to the target is court ⁇ tet, such that an X-ray radiation forming the X-ray field emerges from the target.
  • the x-ray apparatus further includes an adjustable collimator disposed between the target and the work area.
  • the electron beam device includes a second electron source, particularly an electron gun, and a second Elect ⁇ Ronen accelerator, wherein the removable of the second electron source are accelerated by the second electron accelerator in the operating state and the second electron beam thus generated forms the electron beam field.
  • the electron beam apparatus a Ablenkeinrich- tung, with which the electron beam is deflected selectively, so that an effective electron field can be generated whose cross-section is larger than the cross section of the Elect ⁇ Ronen beam.
  • a first high-frequency source and SpeI ⁇ solution of the second electron accelerator are connected to the high-frequency power required for operation is provided a second high frequency source for supplying the first electron accelerator with the required for the operation of high-frequency energy ⁇ .
  • the first and second electron accelerators are fed from a common high frequency source.
  • a high-frequency switch is provided, which is connected between the high-frequency source and the electron accelerator and which, depending on the selected operating mode of the therapy device, feeds the first or the second electron accelerator with the high-frequency energy provided by the high-frequency source.
  • the jet head with the accelerator device is advantageously rotatable about an axis of rotation. This ensures that the target volume can be irradiated under ideal conditions without the patient having to be relocated between two irradiations. Further advantages, features and details of the invention will become apparent from the exemplary embodiment described below and from the drawings. Showing:
  • FIG. 1 shows a combination therapy device in a first embodiment
  • FIG. 2 shows the combination therapy device in a second embodiment
  • FIG. 1 shows schematically an inventive Kombina ⁇ tion therapy device 1 with a rotatable about a rotational axis R-jet head 10.
  • the ejection head 10 is an X-ray generating apparatus 100 of a Röntgenstrahlfel- of X and an electron beam device 200 for generating an electron beam field E.
  • a target volume 310 for example a tumor of a patient 300, can be irradiated.
  • the patient 300 or the target volume 310 is positioned in such a way that the target volume 310 lies in a working area A of the therapy device 1, which can be covered by the beam fields E, R.
  • the axis of rotation R of the jet head 10 is in the example shown here ge ⁇ perpendicular to the plane of the paper.
  • the Zielvolu ⁇ men 310 may be, for example, positioned so that the Rotati ⁇ onsachse R intersects the target volume.
  • x-ray radiation is generated in a manner known per se by irradiation of a target 110 with an electron beam 120.
  • the required for this high-energy electrons are taken from an electron gun 130 and accelerated by means of a linear accelerator 140, which has a plurality of cavities 141-144, to the required energy, for example 6 MeV.
  • the electron beam generated in the accelerator 140 120 leaves the accelerator through a vacuum window 150.
  • the electrons of the electron beam 120 to be braked, said to he ⁇ generating X-rays X is formed.
  • the X-radiation or its central ray X 0 leaves the target substantially in the propagation direction of the electron beam 120.
  • a collimator 160 is provided. This can be moved in the directions indicated by the arrows 161, 162 directions.
  • the collimator 160 may, for example, be designed as a multi-leaf collimator, the lamellae of which are displaceable in the direction of the arrows 161, 162. With such a multi-leaf collimator 160, a comparatively detailed beam field adaptation is possible.
  • the electron beam device 200 also includes an electric ⁇ nenario 230 in the form of an electron gun and an electron accelerator linearly 240 with a plurality of cavities 241- 249th
  • the electrons from the electron source 230 are accelerated by the electron accelerator 240 in a known manner and thus ge ⁇ introduced to an energy of, for example, 20 meV. This energy is sufficient to achieve a target volume in a typical of radiation depth in a size North ⁇ voltage of several cm in the tissue.
  • the electron beam 220 generated in the accelerator 240 leaves the accelerator through a vacuum window 250 and thus forms the electron beam field E.
  • the electron beam field E in this case therefore consists only of the electron beam 220 leaving the accelerator 240.
  • the electron beam field E is aligned with the target volume 310, ie on the tumor.
  • a device 260 can be provided between the vacuum window 250 and the target volume 310, with which the electron beam 220 can be deflected in a targeted manner so that a target volume 310 can also be completely irradiated whose dimensions are greater than the diameter or the cross section of the electron beam 220 In other words, the effective diameter or the cross section of the electron beam field E can be increased by means of appropriate means relative to the diameter of the electron beam 220 leaving the accelerator 240.
  • the device 260 may be configured, for example, to generate an electric and / or magnetic field with which the beam 220 can be deflected in one or two directions perpendicular to the beam direction.
  • a control device 400 is provided, which is connected to the deflection device 260 (not shown) and, for example, using ei ⁇ nes irradiation plan, the deflection 260 so on ⁇ controls that the electron beam 220 is deflected so that the target volume 310 during an irradiation phase , ie in a certain position of the blasting head 10, is largely completely irradiated.
  • the cross section of the electron beam field E then no longer corresponds only to the cross section of the electron beam 220, but rather to the region which can be scanned or scanned with the electron beam 220 with the aid of the deflection device 260.
  • the X-ray apparatus 100 and the electron beam apparatus 200 are used alternately, ie not simultaneously.
  • the supply of the two accelerators 140, 240 with the required for accelerating the electrons high-frequency energy is therefore possible with a single, shared high frequency source 11, which is controlled by the control device 400 depending on the desired mode of the therapy device.
  • a high-frequency switch 12 is connected, which is also controlled by the control unit. 400 feeds the electron accelerator 140 of the X-ray device 100 or the electron accelerator 240 of the electron beam device 200 with the high-frequency energy provided by the RF source 11.
  • the source 11 with the switch 12 and the switch 12 with the accelerators 140, 240 via microwave waveguide 13 are connected.
  • the HF source 11 may be formed, for example, as a magnetron or as a klystron.
  • FIG. 2 it is possible to simultaneously operate the X-ray apparatus 100 and the electron beam apparatus 200.
  • the parent component of the therapy device with Be ⁇ reference numbers are provided.
  • one of the accelerator is at least not as in Figures 1 and 2 ra- dial aligned but axially, ie substantially paral lel ⁇ to the rotation axis R of the therapy device.
  • additional means are needed with which the beam generated in each case can be deflected to the target volume.
  • Such means are known.
  • a device for generating a magnetic field could be used with which the electrons leaving the accelerator can be deflected from their original trajectory.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un appareil combiné de thérapie par rayons X et par faisceaux d'électrons. L'appareil de thérapie comporte une tête de rayonnement qui peut tourner autour d'un axe de rotation et dans laquelle se trouvent un générateur de faisceaux d'électrons servant à produire un champ d'électrons et un générateur de rayons X servant à générer un champ de rayons X. En fonctionnement, les deux champs peuvent être dirigés sur un volume cible, par exemple une tumeur chez un patient. Les deux générateurs de rayonnements possèdent chacun leur propre accélérateur d'électrons optimisé pour les différents modes de fonctionnement. L'énergie HF nécessaire au fonctionnement des accélérateurs est fournie par une source HF commune reliée aux deux accélérateurs par le biais d'un aiguillage. Selon le mode de fonctionnement choisi, cet aiguillage dirige l'énergie HF disponible vers l'accélérateur concerné.
PCT/EP2011/057619 2010-08-27 2011-05-11 Appareil de thérapie WO2012025261A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010035650.6 2010-08-27
DE201010035650 DE102010035650A1 (de) 2010-08-27 2010-08-27 Therapiegerät

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WO2012025261A1 true WO2012025261A1 (fr) 2012-03-01

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DE (1) DE102010035650A1 (fr)
WO (1) WO2012025261A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160193482A1 (en) * 2013-09-11 2016-07-07 The Board Of Trustees Of The Leland Stanford Junior University Arrays of accelerating structures and rapid imaging for facilitating rapid radiation therapies
US10485991B2 (en) 2013-09-11 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for RF power generation and distribution to facilitate rapid radiation therapies
US20210023397A1 (en) * 2018-04-04 2021-01-28 Our United Corporation Microwave power control device and method, and radiotherapy equipment

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230063755A1 (en) * 2021-08-17 2023-03-02 Varian Medical Systems, Inc. Movable/replaceable high intensity target and multiple accelerator systems and methods

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US4726046A (en) * 1985-11-05 1988-02-16 Varian Associates, Inc. X-ray and electron radiotherapy clinical treatment machine
DE102007033052A1 (de) * 2006-07-17 2008-01-31 Nuctech Co. Ltd. Bestrahlungsvorrichtung und Verfahren zur Steuerung/Regelung derselben

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JPS63270066A (ja) * 1987-04-27 1988-11-08 Mitsubishi Electric Corp 放射線治療装置
KR20050083810A (ko) * 2002-10-25 2005-08-26 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 전자 가속기 및 이것을 사용한 방사선 치료장치
US7741624B1 (en) * 2008-05-03 2010-06-22 Velayudhan Sahadevan Single session interactive ultra-short duration super-high biological dose rate radiation therapy and radiosurgery
DE102009007856B4 (de) * 2009-02-06 2011-09-01 Siemens Aktiengesellschaft Therapieanlage mit fest integriertem röntgenbasiertem Bildgebungssystem

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4726046A (en) * 1985-11-05 1988-02-16 Varian Associates, Inc. X-ray and electron radiotherapy clinical treatment machine
DE102007033052A1 (de) * 2006-07-17 2008-01-31 Nuctech Co. Ltd. Bestrahlungsvorrichtung und Verfahren zur Steuerung/Regelung derselben

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160193482A1 (en) * 2013-09-11 2016-07-07 The Board Of Trustees Of The Leland Stanford Junior University Arrays of accelerating structures and rapid imaging for facilitating rapid radiation therapies
US9962562B2 (en) * 2013-09-11 2018-05-08 The Board Of Trustees Of The Leland Stanford Junior University Arrays of accelerating structures and rapid imaging for facilitating rapid radiation therapies
US10485991B2 (en) 2013-09-11 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for RF power generation and distribution to facilitate rapid radiation therapies
US10576303B2 (en) 2013-09-11 2020-03-03 The Board of Trsutees of the Leland Stanford Junior University Methods and systems for beam intensity-modulation to facilitate rapid radiation therapies
US10806950B2 (en) 2013-09-11 2020-10-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid imaging systems and methods for facilitating rapid radiation therapies
US20210023397A1 (en) * 2018-04-04 2021-01-28 Our United Corporation Microwave power control device and method, and radiotherapy equipment
US11679280B2 (en) * 2018-04-04 2023-06-20 Our United Corporation Microwave power control device and method, and radiotherapy equipment

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