WO2012024849A1

WO2012024849A1 - Medical magnesium alloy biodegradability in vitro dynamic simulation test device

Info

Publication number: WO2012024849A1
Application number: PCT/CN2010/076992
Authority: WO
Inventors: 张永君; 刘通; 何柳; 王治平; 耿利红
Original assignee: 华南理工大学
Priority date: 2010-08-27
Filing date: 2010-09-16
Publication date: 2012-03-01
Also published as: CN101968478B; CN101968478A

Abstract

A medical magnesium alloy biodegradability in vitro dynamic simulation test device includes a thermostatic bath (1), a liquid storage tank (2), a circulation pump (3), a flow meter (4), a test cabin (5), an upper sample loader (6), a liquid absorbing tube (7) and a backflow tube (8). The liquid absorbing tube (7) and the backflow tube (8) are arranged in the liquid storage tank (2), respectively. The liquid storage tank (2) is arranged in the thermostatic bath (1). The flow meter (4) and the test cabin (5) are vertically arranged, respectively. The upper sample loader (6) pierces the top cover (20) and is hung in the test cabin (5). The test device has water tubes respectively arranged between inlets of the liquid absorbing tube (7) and the circulation pump (3), between an outlet of the circulation pump (3) and an inlet of the flow meter (4), and between an outlet of the flow meter (4) and the cabin inlet tube (9) of the test cabin (5). The water tubes are further arranged between the cabin outlet tube (10) of the test cabin (5) and the backflow tube (8) for connection to compose a liquid medium circulation path. The device provides a compact structure, convenient use and strong commonality, and provides fast and accurately test and evaluation of the influence of the flow speed, the component, the temperature and the PH value of a medium on the medium corrodibility and the material degradation.

Description

In vitro dynamic simulation test equipment for biodegradation performance of medical magnesium alloy

Technical field

The invention belongs to the field of material performance testing technology and equipment, and relates to a device for dynamic simulation test evaluation of material corrosion degradation performance in a fluid medium, and is particularly suitable for biomedical materials/ In vitro dynamic simulation test of biodegradability of instruments such as medical magnesium alloys and medical device products.

Background technique

With the development of LED technology, high-power LED technology has become increasingly mature. It has many advantages such as high luminous flux, long life, high reliability, energy saving, etc. It is the most potential light source to replace the existing illumination source. In the existing LED lamps, a plurality of power LEDs are generally used in one fixture, so the heat dissipation of the LEDs becomes an important factor affecting the use state and life of the LED lamps. However, the existing LED lamps generally adopt a closed structure, and the heat of the light source and the driving power source cannot be dissipated in a timely and effective manner. Although some lamps are also designed with a special heat dissipation structure, the structure is usually complicated and the heat dissipation effect is not good. In addition, in the existing high-power LED lamps, the LED light source is generally disposed directly toward the ground, and the light emitted by the LED is uneven, which is irritating to the human eye, which seriously affects the lighting effect of the LED lamp, and is prone to cause visual fatigue in long-term viewing. Even the vision is declining.

Materials that are used in a liquid environment, such as medical devices implanted in the human body, ship ships in seawater, etc., and the relative motion between the media have a very important influence on the corrosion degradation behavior. Studies have shown that this relative motion can not only change the corrosion degradation rate of materials/devices, but also change the type of corrosion degradation and its mechanism. Therefore, simulating the actual service conditions, especially the relative motion between the environmental medium and the material/device, is of great significance for revealing the degradation of the medium and the true law of material/device corrosion degradation, developing new materials/new instruments and their degradation control technologies. .

Taking biomedical metal materials as an example, magnesium alloys are expected to become ideal biomedical metal new materials for coronary artery because of their resources, price and performance, especially biodegradation-absorption, biocompatibility and mechanical compatibility. Design and manufacture of highly value-added medical device products such as stents, tissue engineering scaffolds, bone nails, bone plates, bone meshes, and artificial bones. However, the problem of too fast biodegradation has always restricted the biomedical use of magnesium alloys. Therefore, it is of great significance to study the biodegradation behavior of magnesium alloys and to develop magnesium alloy biodegradation control technologies (including new alloy development, surface modification, etc.). In the research and development of biomedical magnesium technology, the evaluation of magnesium alloy biodegradability is one of the core tasks. Existing dynamic simulation test equipment or performance test to meet the performance test of common industrial materials such as iron-based materials, does not consider the specific requirements of biological material test conditions, such as closed, sterile, constant temperature, etc.; or conventional biomedical metal materials The performance test of stainless steel, titanium alloy, etc. is the starting point, and the particularity of magnesium alloy - biodegradability and poor solubility of cathode degradation products in water - based media are not considered. Therefore, there are many shortcomings in the application of existing dynamic simulation test equipment to the biodegradability of magnesium alloys. Due to this limitation, the existing evaluation of the biodegradability of magnesium alloys is still dominated by the classical full immersion corrosion test. Although this method is simple and easy, it has the following main drawbacks: 1) It ignores the important influence of the relative motion of the material/medium except convection on the corrosion degradation behavior of the material. Magnesium alloys are just around the corner for biomedical applications, especially when used as coronary stents, etc., which are inevitably subject to shearing by flowing human body fluids such as blood and tissue fluids; 2) as a direct consequence of 1), related results and in vivo planting The results of the test are far from the same, and it is difficult to accurately predict the in vivo biodegradability of the material/device, which leads to a great compromise in its clinical reference value, thus losing the significance of in vitro research. Therefore, the design and development of dynamic simulation test equipment adapted to the biodegradation characteristics of magnesium alloys has become an urgent task in the research and development of biomedical magnesium technology.

Summary of the invention

The object of the present invention is to provide a dynamic simulation test capable of simulating the relative degradation state of the medium/material under the service state, and conveniently, quickly and accurately evaluating the degradation degradation property of the medium and the corrosion degradation behavior of the material, in view of the deficiencies of the prior art and equipment. device.

The above object of the present invention is achieved by the following technical solutions: an in vitro dynamic simulation test device for biodegradation performance of medical magnesium alloy, including a thermostatic bath, a liquid storage tank, a circulation pump, a flow meter, a test chamber, an upper sample carrier, and a pipette And a return pipe, wherein the liquid suction pipe and the return pipe are respectively placed in the liquid storage tank, the liquid storage tank is placed in the constant temperature tank, the flow meter and the test chamber are respectively vertically fixed, and the upper sample loader is suspended by the top cover of the test cabin In the test chamber; the pipette is located between the nozzle outside the reservoir tank and the inlet of the circulation pump, the outlet of the circulation pump and the inlet of the flow meter, the outlet of the flow meter and the inlet of the test chamber, and the test chamber The outlet pipe and the return pipe are respectively connected by water pipes between the nozzles outside the liquid storage tank, and constitute a liquid medium circulation passage.

The liquid storage tank is a closed rectangular body container, and the partition is divided into left and right two independent tank bodies, wherein the right tank volume is 2.1 times of the volume of the left tank; the top of the liquid storage tank tank is provided with a supply port and a filter. a vent, a suction port and a return port, wherein the supply port has a matching sealing plug, the liquid suction port is located at the top of the left tank of the liquid storage tank and is adjacent to the left side and the front side of the liquid storage tank, and the return port is located at the liquid storage tank The right tank top is adjacent to the right side and the front side of the liquid storage tank, and the liquid suction port and the return port are respectively a passage of the liquid suction pipe and the return pipe through the top of the tank, and the pipe is sealed with the port; There are overflow holes at different height intervals, and the overflow holes are close to the rear side of the liquid storage tank; the left side surface and the right side surface of the liquid storage tank respectively have a liquid discharge port, and the liquid discharge port is close to the bottom and rear sides of the liquid storage tank The internally threaded pipe is seamlessly nested in the overflow hole and the drain port, and the internally threaded pipe has a matching threaded pipe plug.

The test cabin is composed of a five-part inlet duct, a trumpet-like progressive expansion, a cylindrical main compartment, a hatch cover and an exit hatch, wherein the intake duct and the main cabin are respectively located at two ends of the progressive expansion cabin and three A total of the central axis, the outboard tube is located on the side of the main cabin and is more than 21mm from the end of the main hatch; the hatch cover is threadedly connected to the main hatch, wherein the main hatch is externally threaded, and the hatch cover is circumferentially and the main hatch is externally threaded. Matching internal thread, cap-lined gasket; the geometric center of the roof cap is provided with a circular mounting hole for internal positioning of the upper-loading sampler with a circular test hole around the loading hole The sample hole and the test hole are both through holes, and the test hole has a matching sealing plug; the inlet pipe and the outlet pipe are hollow bamboo pipes with uniform inner diameter, and the inner diameter of the outfitting pipe is 2.1 of the inner diameter of the inlet pipe. More than double; the progressive expansion and the main cabin are hollow structures, and the inlet duct and the progressive expansion cabin, the exit cabin and the main cabin are directly connected; a circular porous steady flow plate is provided between the main cabin and the progressive expansion cabin. The outer wall of the main compartment is marked with a height scale and a cylinder inner diameter, respectively, and the bulkhead bulkhead is transparent.

The upper loader consists of a positioning shaft, three loading heads and the same number of connecting bridges as the loading head, wherein one end of the connecting bridge is connected to the lower end of the positioning shaft, and the other end is connected to the upper end of the loading head. The upper end of the positioning shaft and the lower end of the loading head are free ends, and there is a one-to-one correspondence between the loading head and the connecting bridge; the positioning axis and the loading head are both cylindrical; the axis of the loading head and the positioning axis The axes are parallel to each other; the connecting bridges are straight rods of the same size, and the connecting bridges are spatially evenly distributed with the axis of the positioning shaft as a reference line; the dimensions of the loading heads are the same, and the free ends are provided with mounting samples The external thread; the free end of the positioning shaft is a screw matching the circular center hole of the geometrical center of the roof cover; the upper sample carrier is suspended downward in the main compartment of the test chamber through the sample hole.

The pipette and the return pipe are both hard water pipes, and the height of the pipe ends in the liquid storage tank is 3.5-14 mm from the inner side of the bottom of the liquid storage tank.

Compared with the prior art and equipment, the invention has the advantages of compact structure, good controllability, convenient use and strong versatility. The dynamic simulation test of the corrosion degradation performance of the material/device using the present invention can achieve the following outstanding effects:

1) The use of the constant temperature tank, the above-mentioned structural design of the liquid storage tank can ensure that the test medium has a sufficient residence time in the liquid storage tank during the circulation, which is beneficial to the temperature control of the constant temperature tank, and is convenient for accurately studying the temperature change to the medium. And the impact of material properties.

2) The above structural design of the test chamber ensures that the flow of the test medium in the test chamber is smooth and controllable.

3) The invention and utilization of the upper loader realizes the loading of the test sample from the upper end of the sample with hard material, which solves the problem encountered by the traditional "suspended" sample loading method. The structural design of the sample carrier can be carried out by one or three or more. It can realize the one-time loading and subsequent research and test of multiple samples, and achieve the purpose of obtaining multiple sets of data through one test, which can greatly reduce the workload and significantly improve the research and development efficiency. To ensure the controllability of the sample/medium relative motion parameters and the parallelism of the test conditions.

4) The device can easily realize the controlled flow of liquid medium in the test chamber, and can easily, quickly and accurately measure the relative movement speed of the material/medium and the surface area ratio, medium temperature, pH value and composition. The effects of erosion and material corrosion degradability are of great value for revealing the corrosion behavior of materials, developing new materials/new instruments and their degradation control, and are of great significance for improving R&D efficiency, R&D quality and reducing R&D costs.

5) The device is not only suitable for simulating physiological environment in vivo such as dynamic blood/tissue fluid, etc. for biomedical metal materials such as magnesium alloys, titanium alloys, and degradable biomedical polymer materials such as PLLA, SR-PLLA, etc. and their medical device products. Degradation, and is applicable to the dynamic simulation of interaction between conventional engineering materials and military materials and aggressive media such as seawater and accelerated testing of related properties.

DRAWINGS

Figure 1 is a schematic view of the overall structure of the present invention.

2 is a schematic front view showing the structure of the liquid storage tank of the present invention.

Fig. 3 is a schematic top plan view of the liquid storage tank of the present invention.

Figure 4 is a schematic side view showing the structure of the separator in the liquid storage tank of the present invention.

Figure 5 is a schematic view showing the structure of the test chamber of the present invention.

Figure 6 is a schematic view showing the structure of the hatch cover of the test cabin of the present invention.

Fig. 7 is a schematic front view showing the structure of the upper loader of the present invention.

FIG. 8 is a schematic top plan view of the upper position loader of the present invention.

In the picture: 1 - constant temperature tank, 2 - liquid storage tank, 3 - circulation pump, 4 - flow meter, 5 - test chamber, 6 - upper load sampler, 7 - pipette, 8 - return pipe, 9 - feed Cabin, 10 - outboard, 11 - partition, 12 - supply, 13 - vent, 14 - suction, 15 - return, 16 - overflow, 17 - drain, 18 - Expansion, 19-main cabin, 20-cap top cover, 21-packing hole, 22-test hole, 23-porous steady flow plate, 24-positioning shaft, 25-loading head, 26-connecting bridge.

detailed description

The specific implementation of the present invention will be further described below with reference to the accompanying drawings, but the scope and implementation of the present invention are not limited thereto.

As shown in Fig. 1, the present invention comprises a constant temperature tank 1, a liquid storage tank 2, a circulation pump 3, a flow meter 4, a test chamber 5, an upper sample holder 6, a pipette 7 and a return pipe 8. The liquid suction pipe 7 and the return pipe 8 are respectively placed in the liquid storage tank 2, so that the liquid medium enters and exits the liquid storage tank 2 during the test. The liquid storage tank 2 is placed in the constant temperature tank 1, which facilitates the adjustment of the temperature of the liquid in the liquid storage tank 2 by the constant temperature tank 1, thereby ensuring that the temperature of the fluid acting in the test chamber 5 with the sample is within a preset range. The flow meter 4 and the test chamber 5 are vertically fixed to the bracket, respectively, to facilitate regulation of the fluid flow rate and its stability. The upper loader 6 is suspended in the test chamber 5 via the hatch cover 20 of the test chamber 5, and the test sample is loaded with the hard material from the upper end of the sample, thereby solving the traditional "suspended" sample loading method. Puzzle. The pipette 7 is located between the nozzle outside the tank of the liquid storage tank 2 and the inlet of the circulation pump 3, the outlet of the circulation pump 3 and the inlet of the flow meter 4, the outlet of the flow meter 4 and the inlet tube 9 of the test chamber 5. The outlet tube 10 of the test chamber 5 and the outlet tube 8 are respectively connected between the nozzles outside the tank of the liquid storage tank 2 through a water pipe to form a liquid medium circulation passage, and the test medium stored in the liquid storage tank 2 is in the circulation pump. 3 The power provided is circulated in the piping system centered on the test chamber 5.

As shown in FIG. 2, FIG. 3 and FIG. 4, the liquid storage tank 2 is a closed rectangular parallelepiped container, which is divided into left and right two independent tanks by the partition plate 11, wherein the right tank volume is 2.1 times or more of the volume of the left tank. The top of the liquid storage tank 2 is provided with a supply port 12, a vent hole 13 with a filter, and a liquid suction port 14 and a return port 15, wherein the supply port 12 is provided with a matching sealing silicone plug. The supply port 12 is for adding a test medium to the liquid storage tank 2, and the opening of the vent hole 13 facilitates the external discharge of the liquid storage tank 2 and maintains the stability of the air pressure in the liquid storage tank 2. The liquid suction port 14 is located at the top of the left tank of the liquid storage tank 2 and is adjacent to the left side surface and the front side surface of the liquid storage tank 2, and the return flow port 15 is located at the top of the right tank top of the liquid storage tank 2 and is adjacent to the right side of the liquid storage tank 2. The front and front sides, the liquid suction port 14 and the return port 15 are respectively a passage of the pipette 7 and the return pipe 8 through the top of the tank, and the pipe is sealedly connected to the port. Three overflow holes 16 are provided at different heights of the partition 11, and the overflow holes 16 are close to the rear side of the liquid storage tank 2. The above design of the liquid suction port 14, the return port 15 and the partition plate 11 can ensure that the test medium has a sufficient residence time in the liquid storage tank 2 during the cycle, which is favorable for the temperature control of the constant temperature tank 1 and facilitates accurate study of temperature changes. Impact on media and material properties. The left side surface and the right side surface of the liquid storage tank 2 are respectively provided with a liquid discharge port 17 which is close to the bottom of the tank and the rear side of the liquid storage tank 2, so as to facilitate the discharge of the residual liquid in the liquid storage tank 2 after the test is completed. Subsequent cleaning of the liquid storage tank 2. The inner hole pipe is seamlessly nested in the overflow hole 16 and the liquid discharge port 17, and the inner threaded pipe has a matching threaded pipe plug, so that the opening and closing of the opening can be flexibly controlled according to actual conditions. The pipette 7 and the return pipe 8 are hard water pipes to ensure a stable outlet position. The pipette 7 and the return pipe 8 are respectively inserted into the tank through the liquid suction port 14 and the return port 15, and the pipe is sealed and connected with the port, and the pipe end of the tank is 3.5-14 mm away from the inner side of the tank bottom to reduce the test medium. The disturbance effect produced when the liquid storage tank 2 is discharged.

As shown in Fig. 5, the test chamber 5 is composed of an inlet duct 9, a flared progressive expansion tank 18, a cylindrical main compartment 19, a hatch cover 20 and an exit duct 10, wherein the inlet duct 9 and the main compartment 19 are respectively located at both ends of the progressive expansion tank 18 and the three have a central axis. The main compartment 19 has an inner diameter of 70 mm and a length of 490 mm. The outlet duct 10 is located on the side of the main compartment 19 and 28 mm from the end face of the main hatch. The hatch cover 20 is threadedly connected to the main hatch to facilitate frequent loading and unloading of the sample. Wherein the main hatch is externally threaded, the hatch cover 20 is covered with an internal thread matching the external thread of the main hatch, and the hatch cover 20 is covered with a lining gasket to ensure the air between the hatch cover 20 and the test chamber 5. The tightness requirement is to prevent series of problems such as fluid leakage and liquid level fluctuation caused by air leakage. The inlet pipe 9 and the outlet pipe 10 are hollow bamboo pipes of uniform inner diameter, which facilitate the fastening connection of the external hose to the test chamber 5 and ensure the airtightness of the joint. The inlet tube 9 has an inner diameter of 7.0 mm and the outlet tube 10 has an inner diameter of 15.4 mm. The inner diameter ratio of the inlet tube 9 and the outlet tube 10 ensures that the test medium enters and exits the test chamber 5 at different flow rates. Balance to maintain the stability of the liquid level. The progressive expansion tank 18 and the main cabin 19 are hollow structures, and the inlet duct 9 and the flare bay 18 cabin, the outlet duct 10 and the main cabin 19 cabin are directly in communication. A circular porous flow plate 23 is provided between the main chamber 19 and the flared tank 18, and has an inner diameter of 33 mm. The special structural design of the test chamber ensures that the flow of the test medium in the test chamber is smooth and controllable. The outer wall of the main compartment 19 is marked with a height scale and a cylinder inner diameter to facilitate the adjustment of the liquid level and the sample installation position and the measurement of the medium flow rate. The main compartment 19 scale area bulkhead is transparent, which is convenient for tracking the corrosion degradation process of the sample in the test chamber 5.

As shown in Fig. 6, the geometric center of the hatch cover 20 is provided with a circular loading hole 21 having an internal diameter of 6.3 mm. A circular test hole 22 is provided around the sample loading hole 21, and both the sample hole 21 and the test hole 22 are through holes, and the test hole 22 has a matching sealing plug. The presence of the sample loading hole 21 and the matching of the upper sample holder 6 greatly facilitate the mounting and fixing of the sample. The design of the test hole 22 provides convenience for real-time inspection/monitoring of physical and chemical parameters such as medium temperature, pH value and composition in the test chamber 5.

As shown in FIG. 7 and FIG. 8, the upper loader 6 is composed of a positioning shaft 24, three loading heads 25 and three connecting bridges 26, wherein one end of the connecting bridge 26 is connected to the lower end of the positioning shaft 24, and the other end is connected. Connected to the upper end of the loading head 25, the upper end of the positioning shaft 24 and the lower end of the loading head 25 are free ends, and the loading head 25 and the connecting bridge 26 have a one-to-one correspondence. The positioning shaft 24 and the loading head 25 are both cylindrical. The axis of the loading head 25 is parallel to the axis of the positioning shaft 24. The connecting bridges 26 are straight rods of the same size, and the connecting bridges 26 are spatially evenly distributed with the axis of the positioning shaft 24 as a reference line. The above-mentioned structural design of the upper sample loading device 6 can be used for one-time loading and subsequent research and testing of multiple samples, and achieves the purpose of obtaining multiple sets of data through one test, thereby greatly reducing the workload and significantly improving the research and development. At the same time of efficiency, the controllability of the relative motion parameters of the sample/medium and the parallelism of the test conditions are ensured. The loading head 25 has a diameter of 2.8 mm, and the free end thereof is provided with an external thread for mounting the sample. The threaded connection between the loading sample and the sample sample ensures that the loading of the sample is firm and reliable, and at the same time The pose of the sample is controlled. The free end of the positioning shaft 24 is a screw that mates with the geometric center circular loading hole 21 of the roof cap 20, and can be provided with a fastening and sealing nut. The invention and application of the upper loader 6 realizes loading the test sample with the hard material from the upper end thereof, and solves the problem encountered by the traditional "suspended" sample loading method.

Example

In the following, the dynamic simulation test of the biodegradation performance of the medical magnesium alloy by the present invention is taken as an example, and the usage of the present invention is described in detail: a pre-configured test medium such as Hank's simulated body fluid is injected through the supply port 12 of the tank top of the liquid storage tank 2 The liquid storage tank 2; the power switch of the constant temperature tank 1 is turned on, the temperature is preset, the test medium is heated and the temperature is constant; the sample processed with the sample loading hole matched with the sample loading head 25 is subjected to metallographic grinding, washing and drying. Pre-treatment such as micro-arc/anodizing, bionic passivation, etc., and then screwing it into the loading head 25 of the upper-loading sampler 6; the loading head 25 is facing downward, and the positioning shaft 24 of the upper-loading sampler 6 is screwed into the test. The loading hole 21 of the geometric center of the hatch cover 20 of the tank 5; screwing the hatch cover 20 to the main hatch of the test chamber 5; opening the circulation pump 3, and adjusting the medium flow/flow rate to the medium by the flow meter 4 Set the flow rate to stabilize the circulation in the pipeline system; after a certain period of time, close the circulation pump 3, unscrew the top cover 20, remove the upper sample carrier 6, and take the sample on the sample 25; then follow the known method. Such as cleaning, drying, weighing and surface / Surface analysis testing, to obtain a material corrosion degradation rich and comprehensive information, such as the mass change, degradation phase composition, microstructure elements and the like.

Claims

1. In vitro dynamic simulation test equipment for biodegradation of medical magnesium alloy, characterized by including thermostatic bath (1), liquid storage tank (2), circulation pump (3), flow meter (4), test chamber (5), upper load sample (6), a pipette (7) and a return pipe (8), wherein the pipette (7) and the return pipe (8) are respectively placed in the liquid storage tank (2), and the liquid storage tank (2) is placed In the constant temperature tank (1), the flow meter (4) and the test chamber (5) are vertically fixed respectively, and the upper sample holder (6) is suspended from the test chamber (5) via the hatch cover (20) of the test chamber (5). Inside; the pipette (7) is located between the nozzle outside the tank (2) and the inlet of the circulation pump (3), the outlet of the circulation pump (3) and the inlet of the flow meter (4), the flow meter ( 4) Between the inlet and test tubes of the test chamber (5), the outlet tube (10) and the return tube (8) of the test chamber (5) are located between the nozzles outside the tank (2) They are connected by water pipes to form a liquid medium circulation path.

2. The in vitro dynamic simulation test device for biodegradability of medical magnesium alloy according to claim 1, wherein the liquid storage tank (2) is a closed rectangular container, and the partition (11) is divided into left and right independent. The tank body, wherein the right tank volume is more than 2.1 times the volume of the left tank; the tank top (2) tank top is provided with a replenishing port (12), a venting port with a filter (13), a liquid suction port (14) and a return port. (15), wherein the supply port (12) has a matching sealing plug, and the liquid suction port (14) is located at the top of the left tank of the liquid storage tank (2) and adjacent to the left side and the front side of the liquid storage tank (2). The return port (15) is located at the top of the right tank of the liquid storage tank (2) and is adjacent to the right side and the front side of the liquid storage tank (2), and the liquid suction port (14) and the return port (15) are respectively pipettes (7) and the return pipe (8) passes through the passage of the tank top, and the pipe is connected to the port; the overflow hole (16) is arranged at different heights of the partition plate (11), and the overflow hole (16) is close to the storage The rear side of the liquid tank (2); the left side and the right side of the liquid storage tank (2) are respectively provided with a liquid discharge port (17), and the liquid discharge port (17) is close to the liquid storage port (2) and a rear side bottom of the tank; the overflow opening (16) and outlet (17) are nested seamless inner thread, the thread of the threaded tube with matching pipe plug.

3. The in vitro dynamic simulation test apparatus for biodegradability of medical magnesium alloy according to claim 1, characterized in that the test chamber (5) is composed of an inlet duct (9), a flared progressive expansion chamber (18), and a cylindrical shape. The main compartment (19), the hatch cover (20) and the exit hatch (10) are composed of five parts, wherein the inlet duct (9) and the main cabin (19) are respectively located at two ends of the diverging tank (18) and three The central axis, the outboard tube (10) is located on the side of the main compartment (19) and is more than 21 mm from the end of the main hatch; the hatch cover (20) is threadedly connected to the main hatch, wherein the main hatch is externally threaded, the roof The cover (20) covers an inner thread matching the outer thread of the main hatch, and the top is sealed with a gasket; the geometric center of the top cover (20) is provided with an internal thread for positioning the upper loader (6) The circular loading hole (21) is provided with a circular test hole (22) around the loading hole (21), and the sampling hole (21) and the test hole (22) are both through holes and test holes (22) ) with matching sealing plug; the inlet pipe (9) and the outlet pipe (10) are hollow bamboo pipes with uniform inner diameter, and the inner diameter of the outer casing (10) It is more than 2.1 times the inner diameter of the inlet pipe (9); the progressive expansion (18) and the main compartment (19) are hollow structures, and the inlet pipe (9) and the flared (18) compartment and the outbound pipe (10) ) directly communicating with the main compartment (19); a circular porous flow plate (23) is provided between the main compartment (19) and the progressive expansion chamber (18); the outer wall of the main compartment (19) is marked with a height scale and The inner diameter of the cylinder, and the bulkhead bulkhead is transparent.

4. The in vitro dynamic simulation test apparatus for biodegradability of medical magnesium alloy according to claim 1, wherein the upper loader (6) comprises a positioning shaft (24), three loading heads (25), and The same number of connecting bridges (26) as the loading head (25), wherein one end of the connecting bridge (26) is connected to the lower end of the positioning shaft (24), and the other end is connected to the upper end of the loading head (25), the positioning shaft The upper end of (24) and the lower end of the loading head (25) are free ends, and there is a one-to-one correspondence between the loading head (25) and the connecting bridge (26); the positioning shaft (24) and the loading head (25) Both are cylindrical; the axis of the loading head (25) is parallel to the axis of the positioning shaft (24); the connecting bridges (26) are straight rods of the same size, and the connecting bridge (26) is positioned with the axis (24) The axis of the reference line is spatially evenly distributed; the size of the loading head (25) is the same, and the free end is provided with an external thread for mounting the sample; the free end of the positioning shaft (24) is the top cover of the housing (20) Geometric center circular loading hole (21) matching screw; upper load sample (19) (6) the loaded head (25) down through the hole-like means (21) is suspended in a test chamber (5) of the main cabin.

5. The in vitro dynamic simulation test device for biodegradability of medical magnesium alloy according to claim 1, wherein the pipette (7) and the return pipe (8) are both hard water pipes, and the two are in the liquid storage tank (2) The inner nozzle end is 3.5-14 mm from the inner side of the tank bottom of the liquid storage tank (2).