CN201780289U - In-vitro dynamic simulation test equipment for medical magnesium alloy biodegradability - Google Patents
In-vitro dynamic simulation test equipment for medical magnesium alloy biodegradability Download PDFInfo
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- CN201780289U CN201780289U CN2010205081996U CN201020508199U CN201780289U CN 201780289 U CN201780289 U CN 201780289U CN 2010205081996 U CN2010205081996 U CN 2010205081996U CN 201020508199 U CN201020508199 U CN 201020508199U CN 201780289 U CN201780289 U CN 201780289U
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Abstract
The utility model discloses in-vitro dynamic simulation test equipment for medical magnesium alloy biodegradability. The in-vitro dynamic simulation test equipment comprises a thermostatic bath, a liquid storage tank, a circulating pump, a flowmeter, a test cabin, an upper sample loader, a liquid suction pipe and a return pipe, wherein the liquid suction pipe and the return pipe are arranged in the liquid storage tank respectively; the liquid storage tank is arranged in the thermostatic bath; the flowmeter and the test cabin are vertically fixed respectively; the upper sample loader is hung in the test cabin through a cabin top cover of the test cabin; and the liquid suction pipe is connected with the inlet of the circulating pump through a matched water pipe, the outlet of the circulating pump is connected with the inlet of the flowmeter through a matched water pipe, the outlet of the flowmeter is connected with a cabin-in pipe of the test cabin through a matched pipe and a cabin-out pipe of the test cabin is connected with the return pipe through a matched water pipe, thereby forming a liquid medium circulating passage. The equipment has the advantages of compact structure, high generality and the like, and is convenient to use. By using the equipment, influence of the flow rate, components, temperature, pH value and the like of the medium on the medium corrodibility and material degradability can be quickly and accurately tested and evaluated, the development efficiency and quality can be obviously improved, and the development cost is reduced.
Description
Technical field
The utility model belongs to material properties test technology and equipment field, relate to a kind of equipment that in fluid media (medium), the material corrosion degradation property is carried out the dynamic simulant test evaluation, be specially adapted to the external dynamic simulant test of bio-medical material/apparatus such as medical magnesium alloy and medical device product biodegradability thereof.
Background technology
Be on active service material in liquid environment, as the medicine equipment in the implant into body, naval vessels boats and ships etc. in the seawater, and the relative motion between medium has crucial influence to its corrosion degradation behavior.Studies show that this relative motion not only can change the corrosion degradation speed of material/apparatus, and can change its corrosion degraded type and mechanism thereof.Therefore, simulate the especially relative motion between surrounding medium and material/apparatus of actual duty status, medium degraded aggressivity and material/true rule of apparatus corrosion degradation behavior, exploitation new material/new apparatus and degraded control technology thereof etc. are significant for disclosing.
With the bio-medical metal material is example, magnesium alloy is with its resource, price and performance especially biodegradation-absorbability, biocompatibility and mechanical compatibility advantage, being expected to becomes desirable bio-medical metal new material, is used for design, the manufacturing of the high medical device product of added values such as coronary artery bracket, tissue engineering bracket, nail, hone lamella, skeletal framework and artificial bone.But the too fast problem of biodegradation is but restricting the bio-medical of magnesium alloy always.Therefore, research magnesium alloy biodegradation behavior rule, exploitation magnesium alloy biodegradation control technology (comprising new alloy exploitation, surface modification etc.) are significant.In the research and development process of biologic medical magnesium technology, the test and appraisal of magnesium alloy biodegradability are one of core missions.Existing dynamic simulation test device or be principle of design with the performance test of material such as iron to satisfy general industry is not considered the singularity that the biomaterial test condition requires, as seal, aseptic, constant temperature etc.; Or be starting point with the performance test of conventional bio-medical metal material such as stainless steel, titanium alloy etc., do not consider the singularity of magnesium alloy---biodegradability and the slightly solubility of cathode drop hydrolysis products in aqueous medium.Therefore, existing dynamic simulation test device is applied to the magnesium alloy Study on Biodegradability and has many shortcoming.Be so limited, the existing test and appraisal of magnesium alloy biodegradability are still soaked etching test entirely based on classics.Though this method is simple, there is following main drawback: 1) ignored the material impact of the relative motion of material/medium except that convection current to the material corrosion degradation behavior.And magnesium alloy bio-medical within sight, when especially using as coronary artery bracket etc., the inevitable shear action of the human body fluid that can be flowed such as blood, tissue fluid etc.; 2) as 1) direct result, correlated results and body are implanted into test findings and greatly differ from each other, and are difficult to accurately to predict biodegradability in the body of material/apparatus, cause its clinical reference value to be had a greatly reduced quality, thereby have lost the due meaning of in vitro study.Therefore, design, exploitation adapt to the dynamic simulation test device of magnesium alloy biodegradation character, have become the task of top priority of biologic medical magnesium technical research work.
Summary of the invention
The purpose of this utility model is exactly the deficiency at prior art and equipment, provide a kind of can the Simulated Service state under relative motion state between media/material, convenient, fast, estimate the dynamic simulant test equipment of medium degraded aggressivity and material corrosion degradation behavior exactly.
Above-mentioned purpose of the present utility model is achieved through the following technical solutions: the external dynamic simulant test equipment of a kind of medical magnesium alloy biodegradability, comprise calibration cell, fluid reservoir, ebullator, flowmeter, test chamber, upper load sampler, pipette and recirculatory pipe, wherein pipette and recirculatory pipe place fluid reservoir respectively, fluid reservoir places calibration cell, flowmeter and test chamber are vertically fixing respectively, and the upper load sampler cabin top cover in cabin after tested hangs in the test chamber; Pipette is positioned between the inlet of the outer mouth of pipe of fluid reservoir jar and ebullator, between the inlet of the outlet of ebullator and flowmeter, the outlet of flowmeter and test chamber advance between the pipe of cabin, the deliver from vault pipe and the recirculatory pipe of test chamber be positioned between the outer mouth of pipe of fluid reservoir jar and link to each other formation liquid medium circulation path respectively by water pipe.
Described fluid reservoir is sealing side's body container, is divided into left and right two independent tank bodies by dividing plate, and wherein right tank volume is more than 2.1 times of left tank volume; The fluid reservoir tank deck is provided with air hole, liquid sucting port and the refluxing opening of supply mouth, band filter, the sealing-plug of feeding zone coupling wherein, liquid sucting port is positioned at a left side jar tank deck of fluid reservoir and the left surface and the leading flank of close fluid reservoir, refluxing opening is positioned at the right side jar tank deck of fluid reservoir and the right flank and the leading flank of close fluid reservoir, liquid sucting port and refluxing opening are respectively pipette and the recirculatory pipe passages by tank deck, are tightly connected between pipe and the mouth; Differing heights at dividing plate is interval with spout hole, and spout hole is near side after the fluid reservoir; The left surface and the right flank of fluid reservoir have leakage fluid dram, and leakage fluid dram is near at the bottom of the jar of fluid reservoir and trailing flank; All seamless nested rifled tube in spout hole and the leakage fluid dram, the screw thread pipe close of internal thread pipe racks coupling.
Described test chamber constitutes by advancing cabin pipe, horn-like flaring cabin, cylindric main cabin, cabin top cover and deliver from vault pipe five parts, wherein enter cabin pipe and main cabin and lay respectively at the two ends in flaring cabin and three axis altogether, the deliver from vault pipe is positioned at side, main cabin and apart from more than the main hatch end face 21mm; Cabin top cover and main hatch be by being threaded, main hatch band external thread wherein, the internal thread of cabin top cover lid week band and main hatch external thread coupling, caping liner packing washer; Cabin top cover geometric center is provided with the tapped circle that is used for upper load sampler is positioned and adorns the sample hole, is provided with circular instrument connection around dress sample hole, and dress sample hole and instrument connection are through hole, and test the sealing-plug that pore area mates; Advance cabin pipe and deliver from vault pipe and be the uniform hollow ring of internal diameter pipe, and the deliver from vault bore is more than 2.1 times of cabin bore into; Flaring cabin and main cabin are hollow structure, and advance cabin pipe and directly communicate respectively with cabin, flaring cabin, cabin, deliver from vault Guan Yuzhu cabin; Be provided with circular porous stabilier between main cabin and the flaring cabin; Main wall out of my cabin indicates altitude scale and barrel bore respectively, and the scale area bulkhead is transparent.
Described upper load sampler is formed by a locating shaft, three above load sample heads and with the bridge that is connected of a load sample equal number, an end that wherein is connected bridge links to each other with the lower end of locating shaft, the other end links to each other with the upper end of load sample head, the lower end of the upper end of locating shaft and load sample head is free end, and the load sample head is an one-to-one relationship with being connected between the bridge; Locating shaft and load sample head are right cylinder; The axis of load sample head and the axis of locating shaft are parallel to each other; Be connected bridge and be measure-alike straight-bar, and to be connected bridge be that datum line spatially evenly distributes with the axis of locating shaft; The size of load sample head is all identical, and its free end is equipped with the external thread that is used to install sample; The free end of locating shaft is the screw rod that mates with the circular dress of cabin top cover geometric center sample hole; Upper load sampler load sample hangs in the main cabin of test chamber through dress sample hole upside down.
Described pipette and recirculatory pipe are the hard water pipe, and both nose ends in fluid reservoir height of medial surface at the bottom of the fluid reservoir jar is 3.5-14mm.
Compare with prior art and equipment, the utlity model has advantages such as compact conformation, controllability are good, easy to use, highly versatile.Utilize the utility model to carry out the dynamic simulant test of material/apparatus corrosion degradation property, can obtain following outstanding effect:
1) utilization of calibration cell, the said structure design of fluid reservoir can guarantee that tested media has the abundant residence time in cycle period in fluid reservoir, helps the regulation and control of calibration cell to its temperature, is convenient to accurately study temperature variation to medium and effect of material performance.
2) said structure of test chamber design can be guaranteed tested media mobile steady, controlled in test chamber.
3) invention of upper load sampler and utilization have realized test specimen is loaded from the sample upper end with hard material, have solved the difficult problem that tradition " suspension type " load sample method runs into.Load sampler one drags three or above structural design, can realize disposable loading and follow-up study test to a plurality of samples, reach the purpose of obtaining multi-group data by single test, when significantly reducing workload, significantly improving efficiency of research and development, guarantee the sample/controllability of medium relative movement parameters and the collimation of test condition.
4) utilize this equipment to be easy to realize the controlled flowing of liquid medium in test chamber, important parameter such as speed of related movement and surface to volume ratio, medium temperature, pH value and component can test and assess between material/medium convenient, fast, exactly to the influence of erosion medium resistance and material corrosion degradability, have important value to disclosing application technologies such as material corrosion degradation behavior rule, exploitation new material/new apparatus and degraded control thereof, to improve efficiency of research and development and research and development quality, the reduction R﹠D costs are significant.
5) this equipment is not only applicable in the analogue body physiological environment such as dynamic blood/tissue liquid etc. to the degradation of bio-medical metal material such as magnesium alloy, titanium alloy etc. and degradable biological medical macromolecular material such as PLLA, SR-PLLA etc. and medical device product thereof, and is applicable to conventional engineering material and military project material etc. and the dynamic similation of corrosive medium interphase interaction such as seawater and the accelerated test of correlated performance.
Description of drawings
Fig. 1 is the utility model one-piece construction synoptic diagram.
Fig. 2 is the fluid reservoir master TV structure synoptic diagram of the utility model.
Fig. 3 is the fluid reservoir plan structure synoptic diagram of the utility model.
Fig. 4 is the fluid reservoir median septum side-looking structural representation of the utility model.
Fig. 5 is the test chamber structural representation of the utility model.
Fig. 6 is the cabin cap structure synoptic diagram of the test chamber of the utility model.
Fig. 7 is a position load sampler master TV structure synoptic diagram on the utility model.
Fig. 8 is a load sampler plan structure synoptic diagram in position on the utility model.
Among the figure: 1-calibration cell, 2-fluid reservoir, 3-ebullator, 4-flowmeter, 5-test chamber, the upper load sampler of 6-, the 7-pipette, 8-recirculatory pipe, 9-advance cabin pipe, 10-deliver from vault pipe, the 11-dividing plate, 12-supply mouth, 13-air hole, 14-liquid sucting port, the 15-refluxing opening, 16-spout hole, 17-leakage fluid dram, 18-flaring cabin, 19-master cabin, 20-cabin top cover, 21-dress sample hole, 22-instrument connection, 23-porous stabilier, the 24-locating shaft, 25-load sample head, 26-is connected bridge.
Embodiment
Below in conjunction with accompanying drawing concrete enforcement of the present utility model is described further, but protection domain of the present utility model and enforcement are not limited thereto.
As shown in Figure 1, the utility model is made up of calibration cell 1, fluid reservoir 2, ebullator 3, flowmeter 4, test chamber 5, upper load sampler 6, pipette 7 and recirculatory pipe 8.Wherein pipette 7 and recirculatory pipe 8 place fluid reservoir 2 respectively, and liquid medium is into and out of fluid reservoir 2 when being convenient to test.Fluid reservoir 2 places calibration cell 1, helps the regulation and control of fluid temperature in 1 pair of fluid reservoir 2 of calibration cell, thereby guarantees in the test chamber 5 to be in preset range with the temperature of the fluid of sample effect.Flowmeter 4 and test chamber 5 vertical fixing respectively are convenient to fluid flow rate and stationarity thereof etc. and are regulated and control on support.The upper load sampler 6 cabin top cover 20 in cabin 5 after tested hangs in the test chamber 5, has realized test specimen is loaded from the sample upper end with hard material, thereby has solved the difficult problem that tradition " suspension type " load sample method runs into.Pipette 7 is positioned between the inlet of the outer mouths of pipe of 2 jars of fluid reservoirs and ebullator 3, between the inlet of the outlet of ebullator 3 and flowmeter 4, the deliver from vault pipe 10 and the recirculatory pipe 8 that advance 9 of cabin pipes, test chamber 5 of the outlet of flowmeter 4 and test chamber 5 be positioned between 2 jars of outer mouths of pipe of fluid reservoir and link to each other by water pipe respectively, constitute the liquid medium circulation path, the tested media of being convenient to be stored in the fluid reservoir 2 is circulating in the pipe system that with test chamber 5 is the center under the power that ebullator 3 provides.
As Fig. 2, Fig. 3 and shown in Figure 4, fluid reservoir 2 is divided into left and right two independent tank bodies for the cuboid container of sealing by dividing plate 11, and wherein right tank volume is more than 2.1 times of left tank volume.Fluid reservoir 2 tank decks are provided with air hole 13 and the liquid sucting port 14 and the refluxing opening 15 of supply mouth 12, band filter, wherein the sealing silica gel plug of supply mouth 12 band couplings.Supply mouth 12 is used for adding tested media to fluid reservoir 2, and the offering of air hole 13 is convenient to fluid reservoir 2 outside exhausts and kept the stable of air pressure in the fluid reservoir 2.Liquid sucting port 14 is positioned at a left side jar tank deck of fluid reservoir 2 and the left surface and the leading flank of close fluid reservoir 2, refluxing opening 15 is positioned at the right side jar tank deck of fluid reservoir 2 and the right flank and the leading flank of close fluid reservoir 2, liquid sucting port 14 and refluxing opening 15 are respectively pipette 7 and recirculatory pipe 8 passages by tank deck, are tightly connected between pipe and the mouth.Differing heights at dividing plate 11 is provided with three spout holes 16, and spout hole 16 is near side after the fluid reservoir 2.The above-mentioned design of liquid sucting port 14, refluxing opening 15 and dividing plate 11 can guarantee that tested media has the abundant residence time in cycle period in fluid reservoir 2, help the regulation and control of calibration cell 1, be convenient to accurately study temperature variation medium and effect of material performance to its temperature.The left surface of fluid reservoir 2 and right flank are respectively equipped with leakage fluid dram 17, and leakage fluid dram 17 is near at the bottom of jars of fluid reservoir 2 and trailing flank, are convenient to after the end of test (EOT) discharging of raffinates in the fluid reservoir 2 and reach follow-up cleaning to fluid reservoir 2.All seamless nested rifled tube in spout hole 16 and the leakage fluid dram 17, the screw thread pipe close of internal thread pipe racks coupling is convenient to control flexibly according to actual conditions the Push And Release in aperture.Pipette 7 and recirculatory pipe 8 are the hard water pipe, can guarantee that its exit position is stable.Pipette 7 and recirculatory pipe 8 respectively in liquid sucting port 14 and refluxing opening 15 inserts jar, pipe with mouthful between be tightly connected medial surface 3.5-14mm at the bottom of its jar inner spout end distance jar, the disturbance effect of generation when reducing tested media into and out of fluid reservoir 2.
As shown in Figure 5, test chamber 5 constitutes by advancing cabin pipe 9, horn-like flaring cabin 18, cylindric main cabin 19, cabin top cover 20 and deliver from vault pipe 10 5 parts, wherein enter two ends and the common axis of three that cabin pipe 9 and main cabin 19 lay respectively at flaring cabin 18, main cabin 19 internal diameters are 70mm, and length is 490mm.Deliver from vault pipe 10 is positioned at 19 sides, main cabin and apart from main hatch end face 28mm.Cabin top cover 20 and main hatch make things convenient for the frequent loading and unloading of sample by being threaded.Main hatch band external thread wherein, 20 lid weeks of cabin top cover are with the internal thread with main hatch external thread coupling, top cover 20 caping liner packing washers in cabin can be guaranteed the impermeability requirement between cabin top cover 20 and the test chamber 5, prevent to leak because of gas leakage causes fluid, serial problem such as level fluctuation.Advance cabin pipe 9 and deliver from vault pipe 10 and be the uniform hollow ring of internal diameter pipe, be convenient to the impermeability that is fastenedly connected and guarantees the junction of external hose and test chamber 5.The internal diameter that advances cabin pipe 9 is 7.0mm, and the internal diameter of deliver from vault pipe 10 is 15.4mm, the internal diameter ratio design of advancing cabin pipe 9 and deliver from vault pipe 10 can guarantee tested media under different in flow rate test chamber 5 in into and out of balance, thereby keep wherein stablizing of liquid level.Flaring cabin 18 and main cabin 19 are hollow structure, and advance cabin pipe 9 and directly communicate respectively with 19 cabins, main cabin with 18 cabins, flaring cabin, deliver from vault pipe 10.Be provided with circular porous stabilier 23 between main cabin 19 and the flaring cabin 18, its internal diameter is 33mm.The above-mentioned special structural design of test chamber can be guaranteed tested media mobile steady, controlled in test chamber.Main cabin 19 outer walls indicate altitude scale and barrel bore respectively, are convenient to the adjustment of liquid level and sample installation site and the measuring and calculating of velocity of medium.Main cabin 19 scale area bulkheads are transparent, are convenient to the corrosion degradation process of sample in the tracking and testing cabin 5.
As shown in Figure 6, top cover 20 geometric centers in cabin are provided with the circle dress sample hole 21 that tapped aperture is 6.3mm.Be provided with circular instrument connection 22 around dress sample hole 21, dress sample hole 21 and instrument connection 22 are through hole, and the sealing-plug of instrument connection 22 band couplings.The existence in dress sample hole 21 and upper load sampler 6 supporting is very easy to the installation, fixing of sample.The design of instrument connection 22 is for the real-time detecting/monitoring of physical and chemical parameters such as medium temperatures, pH value and component in the test chamber 5 provides convenience.
As Fig. 7, shown in Figure 8, upper load sampler 6 is made up of a locating shaft 24, three load sample 25 and three linking bridges 26, an end that wherein is connected bridge 26 links to each other with the lower end of locating shaft 24, the upper end of the other end and load sample 25 links to each other, the lower end of the upper end of locating shaft 24 and load sample 25 is free end, and load sample 25 is one-to-one relationship with being connected between the bridge 26.Locating shaft 24 and load sample 25 is right cylinder.The axis of load sample 25 and the axis of locating shaft 24 are parallel to each other.Be connected bridge 26 and be measure-alike straight-bar, and to be connected bridge 26 be that datum line spatially evenly distributes with the axis of locating shaft 24.Upper load sampler 6 one drags three or the design of above said structure, can realize disposable loading and follow-up study test to a plurality of samples, reach the purpose of obtaining multi-group data by single test, when significantly reducing workload, significantly improving efficiency of research and development, guarantee the sample/controllability of medium relative movement parameters and the collimation of test condition.Load sample 25 diameter are 2.8mm, and its free end is equipped with the external thread that is used to install sample, the design that is threaded between load sample head and specimen sample, the loading that can guarantee sample firmly, reliable, can control the pose of sample simultaneously.The free end of locating shaft 24 is and the screw rod of the circular dress of cabin top cover 20 geometric centers sample hole 21 couplings, can be with fastening and the sealing nut.The invention of upper load sampler 6 and application have realized test specimen is loaded from its upper end with hard material, have solved the difficult problem that tradition " suspension type " load sample method runs into.
Embodiment
Be example with the dynamic simulant test that utilizes the utility model to carry out the medical magnesium alloy biodegradability below, introduce usage of the present utility model in detail: with the supply mouth 12 injection fluid reservoirs 2 by fluid reservoir 2 tank decks such as pre-configured tested media such as Hank ' s simulated body fluid; Open the power switch of calibration cell 1, preset temperature heats tested media and it is carried out constant temperature; The sample that is processed with the dress sample holes of load sample 25 couplings is carried out pre-treatments such as metallographic polishing, cleaning, drying, the differential of the arc/anodic oxidation, bionical passivation, afterwards it is screwed in the load sample 25 of upper load sampler 6; Load sample 25 screws in the locating shaft 24 of upper load sampler 6 in the dress sample hole 21 of cabin top cover 20 geometric centers of test chambers 5 down; The main hatch of cabin top cover 20 with test chamber 5 spun; Open ebullator 3, by flowmeter 4 adjust rate-of flow/flow velocitys to medium with preset flow rate in the pipe system stable circulation; Close ebullator 3 after the specific period, screw off cabin top cover 20, unload upper load sampler 6, take off the sample on the load sample 25; Afterwards according to known method carry out subsequent operation as clean, dry, weigh and surface/cross-section analysis test etc., can obtain the abundant and comprehensive information of material corrosion degraded, form and microscopic appearance etc. as mass change, catabolite phase composition, element.
Claims (5)
1. the external dynamic simulant test equipment of medical magnesium alloy biodegradability, it is characterized in that comprising calibration cell (1), fluid reservoir (2), ebullator (3), flowmeter (4), test chamber (5), upper load sampler (6), pipette (7) and recirculatory pipe (8), wherein pipette (7) and recirculatory pipe (8) place fluid reservoir (2) respectively, fluid reservoir (2) places calibration cell (1), flowmeter (4) and test chamber (5) are vertically fixing respectively, and upper load sampler (6) the cabin top cover (20) of cabin (5) after tested hangs in the test chamber (5); Pipette (7) is positioned between the inlet of the outer mouth of pipe of fluid reservoir (2) jar and ebullator (3), between the inlet of the outlet of ebullator (3) and flowmeter (4), the outlet of flowmeter (4) and test chamber (5) advance between cabin pipe (9), the deliver from vault pipe (10) and the recirculatory pipe (8) of test chamber (5) be positioned between the mouth of pipe outside fluid reservoir (2) jar and link to each other formation liquid medium circulation path respectively by water pipe.
2. the external dynamic simulant test equipment of medical magnesium alloy biodegradability according to claim 1, it is characterized in that: described fluid reservoir (2) is sealing side's body container, be divided into left and right two independent tank bodies by dividing plate (11), wherein right tank volume is more than 2.1 times of left tank volume; Fluid reservoir (2) tank deck is provided with air hole (13), liquid sucting port (14) and the refluxing opening (15) of supply mouth (12), band filter, wherein supply mouth (12) is with the sealing-plug of coupling, liquid sucting port (14) is positioned at a left side jar tank deck of fluid reservoir (2) and the left surface and the leading flank of close fluid reservoir (2), refluxing opening (15) is positioned at the right side jar tank deck of fluid reservoir (2) and the right flank and the leading flank of close fluid reservoir (2), liquid sucting port (14) and refluxing opening (15) are respectively pipette (7) and recirculatory pipe (8) passages by tank deck, are tightly connected between pipe and the mouth; Differing heights at dividing plate (11) is interval with spout hole (16), and the close fluid reservoir (2) of spout hole (16) is the side afterwards; The left surface of fluid reservoir (2) and right flank are respectively equipped with leakage fluid dram (17), and leakage fluid dram (17) is near at the bottom of the jar of fluid reservoir (2) and trailing flank; All seamless nested rifled tube in spout hole (16) and the leakage fluid dram (17), the screw thread pipe close of internal thread pipe racks coupling.
3. the external dynamic simulant test equipment of medical magnesium alloy biodegradability according to claim 1, it is characterized in that: described test chamber (5) constitutes by advancing cabin pipe (9), horn-like flaring cabin (18), cylindric main cabin (19), cabin top cover (20) and deliver from vault pipe (10) five parts, wherein enter two ends and the common axis of three that cabin pipe (9) and main cabin (19) lays respectively at flaring cabin (18), deliver from vault pipe (10) is positioned at (19) side, main cabin and apart from more than the main hatch end face 21mm; Cabin top cover (20) and main hatch be by being threaded, main hatch band external thread wherein, the internal thread of cabin top cover (20) lid week band and main hatch external thread coupling, caping liner packing washer; Cabin top cover (20) geometric center is provided with the tapped circle that is used for upper load sampler (6) is positioned and adorns sample hole (21), be provided with circular instrument connection (22) on every side in dress sample hole (21), dress sample hole (21) and instrument connection (22) are through hole, and the sealing-plug of instrument connection (22) band coupling; Advance cabin pipe (9) and deliver from vault pipe (10) and be the uniform hollow ring of internal diameter pipe, and deliver from vault pipe (10) internal diameter is that into more than 2.1 times of (9) internal diameter are managed in the cabin; Flaring cabin (18) and main cabin (19) are hollow structure, and advance cabin pipe (9) and directly communicate respectively with cabin, main cabin (19) with cabin, flaring cabin (18), deliver from vault pipe (10); Be provided with circular porous stabilier (23) between main cabin (19) and flaring cabin (18); Main cabin (19) outer wall indicates altitude scale and barrel bore respectively, and the scale area bulkhead is transparent.
4. the external dynamic simulant test equipment of medical magnesium alloy biodegradability according to claim 1, it is characterized in that: described upper load sampler (6) is formed by a locating shaft (24), three above load sample heads (25) and with the bridge (26) that is connected of load sample head (25) equal number, an end that wherein is connected bridge (26) links to each other with the lower end of locating shaft (24), the other end links to each other with the upper end of load sample head (25), the lower end of the upper end of locating shaft (24) and load sample head (25) is free end, and load sample head (25) is an one-to-one relationship with being connected between the bridge (26); Locating shaft (24) is right cylinder with load sample head (25); The axis of the axis of load sample head (25) and locating shaft (24) is parallel to each other; Be connected bridge (26) and be measure-alike straight-bar, and to be connected bridge (26) be that datum line spatially evenly distributes with the axis of locating shaft (24); The size of load sample head (25) is all identical, and its free end is equipped with the external thread that is used to install sample; The free end of locating shaft (24) is the screw rod that mates with cabin top cover (20) geometric center circular dress sample hole (21); Upper load sampler (6) load sample head (25) hangs in the main cabin (19) of test chamber (5) through dress sample hole (21) down.
5. the external dynamic simulant test equipment of medical magnesium alloy biodegradability according to claim 1, it is characterized in that: pipette (7) and recirculatory pipe (8) are the hard water pipe, and both nose ends in fluid reservoir (2) are 3.5-14mm apart from the height of fluid reservoir (2) jar end medial surface.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010205081996U CN201780289U (en) | 2010-08-27 | 2010-08-27 | In-vitro dynamic simulation test equipment for medical magnesium alloy biodegradability |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010205081996U CN201780289U (en) | 2010-08-27 | 2010-08-27 | In-vitro dynamic simulation test equipment for medical magnesium alloy biodegradability |
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| CN201780289U true CN201780289U (en) | 2011-03-30 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101968478A (en) * | 2010-08-27 | 2011-02-09 | 华南理工大学 | Equipment for dynamically simulating and testing biodegradability of medical magnesium alloy in vitro |
| CN102426183A (en) * | 2011-11-12 | 2012-04-25 | 重庆理工大学 | Corrosion and degradation experiment device for external medical metal body in dynamic corrosion environment |
| CN104020258A (en) * | 2014-06-16 | 2014-09-03 | 东华大学 | Dynamic simulation degradation device and testing method for evaluating degradable ureter bracket tube |
| CN109142365A (en) * | 2018-11-01 | 2019-01-04 | 西安交通大学医学院第附属医院 | A kind of simulated gastrointestinal condition experiment porch |
-
2010
- 2010-08-27 CN CN2010205081996U patent/CN201780289U/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101968478A (en) * | 2010-08-27 | 2011-02-09 | 华南理工大学 | Equipment for dynamically simulating and testing biodegradability of medical magnesium alloy in vitro |
| WO2012024849A1 (en) * | 2010-08-27 | 2012-03-01 | 华南理工大学 | Medical magnesium alloy biodegradability in vitro dynamic simulation test device |
| CN101968478B (en) * | 2010-08-27 | 2013-02-13 | 华南理工大学 | Equipment for dynamically simulating and testing biodegradability of medical magnesium alloy in vitro |
| CN102426183A (en) * | 2011-11-12 | 2012-04-25 | 重庆理工大学 | Corrosion and degradation experiment device for external medical metal body in dynamic corrosion environment |
| CN102426183B (en) * | 2011-11-12 | 2014-01-15 | 重庆理工大学 | Corrosion and degradation experiment device for external medical metal body in dynamic corrosion environment |
| CN104020258A (en) * | 2014-06-16 | 2014-09-03 | 东华大学 | Dynamic simulation degradation device and testing method for evaluating degradable ureter bracket tube |
| CN109142365A (en) * | 2018-11-01 | 2019-01-04 | 西安交通大学医学院第附属医院 | A kind of simulated gastrointestinal condition experiment porch |
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