WO2012017116A3 - Method for producing biosensors - Google Patents

Method for producing biosensors Download PDF

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Publication number
WO2012017116A3
WO2012017116A3 PCT/ES2011/070536 ES2011070536W WO2012017116A3 WO 2012017116 A3 WO2012017116 A3 WO 2012017116A3 ES 2011070536 W ES2011070536 W ES 2011070536W WO 2012017116 A3 WO2012017116 A3 WO 2012017116A3
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
areas
stage
tio
biological
Prior art date
Application number
PCT/ES2011/070536
Other languages
Spanish (es)
French (fr)
Other versions
WO2012017116A2 (en
Inventor
Ruy SANZ GONZÁLEZ
Pérez Girón JOSÉ VICENTE
Miriam Jaafar Ruiz-Castellanos
Oscar DE LUIS JIMÉNEZ
José Antonio MAS GUTIÉRREZ
José Luis SANZ MONTAÑA
Vicente PÉREZ BOTO
Agustina Asenjo Barahona
Manuel De La Concepción HERNÁNDEZ VÉLEZ
Mercedes SALAICES SÁNCHEZ
Manuel ROS PÉREZ
Antonio Coloma Jerez
María Jesús ALONSO GORDO
Jorge Puente Prieto
Jens Jensen
Original Assignee
Nanoate, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoate, S.L. filed Critical Nanoate, S.L.
Publication of WO2012017116A2 publication Critical patent/WO2012017116A2/en
Publication of WO2012017116A3 publication Critical patent/WO2012017116A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00206—Processes for functionalising a surface, e.g. provide the surface with specific mechanical, chemical or biological properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00533—Sheets essentially rectangular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/02—Sensors
    • B81B2201/0214—Biosensors; Chemical sensors

Abstract

The invention relates to a method for producing biosensors that include a substrate of TiO2, that includes: a first stage of ionic irradiation of certain areas of a substrate of rutile monocrystalline titanium oxide, resulting in amorphous TiO2 in the areas of the irradiated substrate; a second stage of depositing a biological or chemical substance or matter on at least one of the areas of amorphous TiO2 produced in the preceding stage in order to manufacture microelectronic or biotechnology devices such a biological microarray or microchip.
PCT/ES2011/070536 2010-08-05 2011-07-21 Method for producing biosensors WO2012017116A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201031224A ES2351495B1 (en) 2010-08-05 2010-08-05 BIOSENSOR OBTAINING PROCEDURE.
ESP201031224 2010-08-05

Publications (2)

Publication Number Publication Date
WO2012017116A2 WO2012017116A2 (en) 2012-02-09
WO2012017116A3 true WO2012017116A3 (en) 2012-03-29

Family

ID=43499760

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2011/070536 WO2012017116A2 (en) 2010-08-05 2011-07-21 Method for producing biosensors

Country Status (2)

Country Link
ES (1) ES2351495B1 (en)
WO (1) WO2012017116A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148401A1 (en) * 2001-11-09 2003-08-07 Anoop Agrawal High surface area substrates for microarrays and methods to make same
US20060134397A1 (en) * 2002-11-26 2006-06-22 Smith Roger E Microporous materials, methods, and articles for localizing and quantifying analytes
WO2007009994A1 (en) * 2005-07-21 2007-01-25 Tethis S.R.L. Support having nanostructured titanium dioxide film and uses thereof
US20100108490A1 (en) * 2008-11-06 2010-05-06 Hamers Robert J Molecular and biomolecular functionalization of metal oxides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239193A1 (en) 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
WO2006137891A2 (en) * 2004-09-29 2006-12-28 University Of Florida Research Foundation, Inc. Membrane with nanochannels for detection of molecules
EP1846249A2 (en) 2005-01-10 2007-10-24 Bioforce Nanosciences, Inc. Topographically indexed support substrates
WO2008119080A1 (en) 2007-03-28 2008-10-02 Life Bioscience Inc. Compositions and methods to fabricate a photoactive substrate suitable for shaped glass structures
WO2010011939A2 (en) 2008-07-25 2010-01-28 Life Bioscience, Inc. Assay plates, methods and systems having one or more etched features

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148401A1 (en) * 2001-11-09 2003-08-07 Anoop Agrawal High surface area substrates for microarrays and methods to make same
US20060134397A1 (en) * 2002-11-26 2006-06-22 Smith Roger E Microporous materials, methods, and articles for localizing and quantifying analytes
WO2007009994A1 (en) * 2005-07-21 2007-01-25 Tethis S.R.L. Support having nanostructured titanium dioxide film and uses thereof
US20100108490A1 (en) * 2008-11-06 2010-05-06 Hamers Robert J Molecular and biomolecular functionalization of metal oxides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DO-KYUN KIM ET AL: "Development of a Label-Free Optical Biosensor Using Porous Anodic Alumina (PAA) Layer Chip", SENSORS, 2006. 5TH IEEE CONFERENCE ON, IEEE, PI, 22 October 2006 (2006-10-22), pages 132 - 135, XP032024655, ISBN: 978-1-4244-0375-2, DOI: 10.1109/ICSENS.2007.355736 *
JENSEN J ET AL: "Heavy ion beam-based nano- and micro-structuring of TiO2 single crystals using self-assembled masks", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - B:BEAM INTERACTIONS WITH MATERIALS AND ATOMS, ELSEVIER, AMSTERDAM, NL, vol. 266, no. 12-13, 1 June 2008 (2008-06-01), pages 3113 - 3119, XP022706991, ISSN: 0168-583X, [retrieved on 20080403], DOI: 10.1016/J.NIMB.2008.03.220 *
RUY SANZ ET AL: "Fabrication of Well-Ordered High-Aspect-Ratio Nanopore Arrays in TiO 2 Single Crystals", NANO LETTERS, vol. 6, no. 5, 1 May 2006 (2006-05-01), pages 1065 - 1068, XP055017341, ISSN: 1530-6984, DOI: 10.1021/nl0602185 *

Also Published As

Publication number Publication date
ES2351495B1 (en) 2011-09-08
ES2351495A1 (en) 2011-02-07
WO2012017116A2 (en) 2012-02-09

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