WO2012005550A3 - 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법 - Google Patents
담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법 Download PDFInfo
- Publication number
- WO2012005550A3 WO2012005550A3 PCT/KR2011/005033 KR2011005033W WO2012005550A3 WO 2012005550 A3 WO2012005550 A3 WO 2012005550A3 KR 2011005033 W KR2011005033 W KR 2011005033W WO 2012005550 A3 WO2012005550 A3 WO 2012005550A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gallbladder carcinoma
- treating
- carcinoma
- metastasis
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
본 발명은 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법에 관한 것이다. 본 발명의 담낭암 세포 표면의 L1CAM 단백질을 인식하며 담낭암 조직에 특이적으로 결합하는 항체 또는 siRNA, shRNA 또는 안티센스 올리고뉴클레오티드 및 이를 포함하는 약제학적 조성물은 담낭암의 성장, 침윤 및 이동을 억제 및 세포 사멸을 유도할 수 있으므로, 보다 안전하면서도 효과적인 담낭암의 예방 및 치료에 널리 활용될 수 있을 것이다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100066055 | 2010-07-08 | ||
KR10-2010-0066055 | 2010-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012005550A2 WO2012005550A2 (ko) | 2012-01-12 |
WO2012005550A3 true WO2012005550A3 (ko) | 2012-04-26 |
Family
ID=45441681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/005033 WO2012005550A2 (ko) | 2010-07-08 | 2011-07-08 | 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101271964B1 (ko) |
WO (1) | WO2012005550A2 (ko) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2322221E (pt) | 2008-08-05 | 2014-09-19 | Toray Industries | Composição farmacêutica para tratamento e prevenção de cancro |
HUE027332T2 (en) | 2008-08-05 | 2016-09-28 | Toray Industries | Cancer Detection Method |
PT2532743E (pt) | 2010-02-04 | 2015-08-04 | Toray Industries | Composição farmacêutica para o tratamento e/ou a prevenção de cancro |
US9796775B2 (en) | 2011-08-04 | 2017-10-24 | Toray Industries, Inc. | Method for detecting pancreatic cancer |
PT3351630T (pt) | 2011-08-04 | 2019-12-30 | Toray Industries | Composição farmacêutica compreendendo anticorpos anti caprin-1 para tratar e/ou prevenir o cancro |
JP6003650B2 (ja) | 2011-08-04 | 2016-10-05 | 東レ株式会社 | 膵臓癌の治療及び/又は予防用医薬組成物 |
RU2633505C2 (ru) | 2012-02-21 | 2017-10-12 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
CA2864869C (en) | 2012-02-21 | 2021-10-19 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
MX360208B (es) | 2012-02-21 | 2018-10-24 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
AU2013223137B2 (en) | 2012-02-21 | 2017-10-19 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
PL2832365T3 (pl) | 2012-03-30 | 2018-04-30 | Toray Industries, Inc. | Kompozycja farmaceutyczna do leczenia i/lub zapobiegania nowotworowi wątroby |
JP6107655B2 (ja) * | 2012-03-30 | 2017-04-05 | 東レ株式会社 | 胆嚢癌の治療及び/又は予防用医薬組成物 |
HUE043162T2 (hu) | 2012-07-19 | 2019-08-28 | Toray Industries | Eljárás rák detektálására |
CN104471404B (zh) | 2012-07-19 | 2017-03-01 | 东丽株式会社 | 癌的检测方法 |
JP6447130B2 (ja) | 2013-08-09 | 2019-01-09 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
KR20180079232A (ko) * | 2016-12-30 | 2018-07-10 | 강원대학교산학협력단 | L1cam 단백질에 특이적으로 결합하는 항체 및 피리미딘 유사체 및/또는 플라틴계 항암제를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
WO2020003210A1 (en) | 2018-06-29 | 2020-01-02 | Kangwon National University University-Industry Cooperation Foundation | Anti-l1cam antibodies and uses thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100931976B1 (ko) * | 2006-08-23 | 2009-12-15 | 한국생명공학연구원 | 담도암 치료용 약제학적 조성물 및 이를 이용한 담도암의성장, 전이 억제 및 치료 방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100060351A (ko) * | 2008-11-27 | 2010-06-07 | 한국생명공학연구원 | L1cam의 활성 또는 발현을 억제하는 물질 및 항암제를포함하는 항암용 조성물 |
KR101501736B1 (ko) * | 2008-12-05 | 2015-03-12 | 한국생명공학연구원 | 인간 및 마우스에서 발현하는 l1cam에 특이적으로 결합하는 재조합 단일클론항체 및 그 이용 |
-
2011
- 2011-07-08 KR KR1020110067874A patent/KR101271964B1/ko active IP Right Grant
- 2011-07-08 WO PCT/KR2011/005033 patent/WO2012005550A2/ko active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100931976B1 (ko) * | 2006-08-23 | 2009-12-15 | 한국생명공학연구원 | 담도암 치료용 약제학적 조성물 및 이를 이용한 담도암의성장, 전이 억제 및 치료 방법 |
Non-Patent Citations (2)
Title |
---|
S. SEBENS MUERKOSTER ET AL.: "Drug-induced expression of the cellular adhension molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells", ONCOGENE, vol. 26, no. 19, 2007, pages 2759 - 2768, XP002436286, DOI: doi:10.1038/sj.onc.1210076 * |
SHIDENG BAO ET AL.: "Targeting cancer stem cells through L1CAM suppresses glioma growth", CANCER RESEARCH, vol. 68, no. 15, 2008, pages 6043 - 6048 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012005550A2 (ko) | 2012-01-12 |
KR20120005412A (ko) | 2012-01-16 |
KR101271964B1 (ko) | 2013-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2012005550A3 (ko) | 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법 | |
WO2009109911A8 (en) | Methods of treating chronic pain | |
WO2008137867A3 (en) | Compositions comprising mir34 therapeutic agents for treating cancer | |
WO2013059396A3 (en) | Treatment of cancer with tor kinase inhibitors | |
WO2011079902A3 (en) | Biological inhibitors of ror1 capable of inducing cell death | |
WO2012145183A3 (en) | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer | |
WO2012062925A3 (en) | Compounds and methods for treating pain | |
WO2010056737A3 (en) | Methods and compositions involving mirnas in cancer stem cells | |
WO2011146568A8 (en) | Predicting response to a her inhibitor | |
SG169988A1 (en) | Rnai inhibition of alpha-enac expression | |
WO2007143086A3 (en) | Delivery method | |
WO2012170807A3 (en) | Anti-pseudomonas psl binding molecules and uses thereof | |
WO2012138789A3 (en) | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors | |
WO2012006181A3 (en) | Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer | |
WO2009158374A3 (en) | Inhibitors of akt activity | |
WO2009143292A9 (en) | Method of treating pneumoconiosis with oligodeoxynucleotides | |
WO2014062878A3 (en) | Treatment of prostate cancer with tor kinase inhibitors | |
TWI369590B (en) | Treatment liquid for resist substrate, and method of treating resist substrate using the same | |
WO2009127414A3 (en) | Inhibition of angiogenesis and tumor metastasis | |
WO2012139043A3 (en) | Selective neuronal nitric oxide synthase inhibitors | |
WO2010054328A3 (en) | Compositions and methods for the inhibition of cripto/grp78 complex formation and signaling | |
WO2011011061A3 (en) | Method of regulating angiogenesis and lymphangiogenesis, and a pharmaceutical composition for effecting anti-angiogenic and anti-lymphangiogenic cancer therapy | |
CA2810119C (en) | Clec14a inhibitors | |
WO2010085151A3 (en) | Means and methods for modulating notch3 protein expression and/or the coding region of notch3; compositions and use thereof in the treatment of cadasil | |
WO2009044153A3 (en) | Inhibitors and uses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11803836 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 11803836 Country of ref document: EP Kind code of ref document: A2 |