WO2011155797A3 - 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 - Google Patents
결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 Download PDFInfo
- Publication number
- WO2011155797A3 WO2011155797A3 PCT/KR2011/004284 KR2011004284W WO2011155797A3 WO 2011155797 A3 WO2011155797 A3 WO 2011155797A3 KR 2011004284 W KR2011004284 W KR 2011004284W WO 2011155797 A3 WO2011155797 A3 WO 2011155797A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hemioxalate
- crystalline
- desmethylvenlafaxine
- preparation
- pharmaceutical composition
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 용해도를 극대화시키고, 비흡습성을 나타내어 제약학적으로 바람직한 고형 물질의 물리화학적 특성을 갖는 결정형 O-데스메틸벤라팍신 헤미옥살레이트, 그의 제조방법 및 약제학적 조성물에 관한 것이다. 본 발명에 따른 결정형 O-데스메틸벤라팍신 헤미옥살레이트는 용해도가 높아 약물의 생체이용률을 증가시킬 수 있고, 조성물 크기에 제한없이 매우 용이하게 여러 제형을 설계할 수 있으며, 동물의 투여 한계 부피에 관계없이 약물을 고용량으로 투여 가능하므로 발현 가능한 독성을 확인하기에 용이하고, 흡습성이 적기 때문에 원료 유통 및 제제 생산에 적합하다.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100054937 | 2010-06-10 | ||
KR10-2010-0054937 | 2010-06-10 | ||
KR10-2011-0056295 | 2011-06-10 | ||
KR1020110056295A KR20110135353A (ko) | 2010-06-10 | 2011-06-10 | 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 |
Publications (2)
Publication Number | Publication Date |
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WO2011155797A2 WO2011155797A2 (ko) | 2011-12-15 |
WO2011155797A3 true WO2011155797A3 (ko) | 2012-05-03 |
Family
ID=45098553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/004284 WO2011155797A2 (ko) | 2010-06-10 | 2011-06-10 | 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011155797A2 (ko) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2119695A1 (en) * | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
WO2010008735A2 (en) * | 2008-06-16 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Solid states of o-desmethylvenlaf axine salts |
KR20100015923A (ko) * | 2007-04-09 | 2010-02-12 | 세프라코 아이엔시. | 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들 |
-
2011
- 2011-06-10 WO PCT/KR2011/004284 patent/WO2011155797A2/ko active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100015923A (ko) * | 2007-04-09 | 2010-02-12 | 세프라코 아이엔시. | 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들 |
EP2119695A1 (en) * | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
WO2010008735A2 (en) * | 2008-06-16 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Solid states of o-desmethylvenlaf axine salts |
Also Published As
Publication number | Publication date |
---|---|
WO2011155797A2 (ko) | 2011-12-15 |
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