WO2011155797A3 - 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 - Google Patents

결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 Download PDF

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Publication number
WO2011155797A3
WO2011155797A3 PCT/KR2011/004284 KR2011004284W WO2011155797A3 WO 2011155797 A3 WO2011155797 A3 WO 2011155797A3 KR 2011004284 W KR2011004284 W KR 2011004284W WO 2011155797 A3 WO2011155797 A3 WO 2011155797A3
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WO
WIPO (PCT)
Prior art keywords
hemioxalate
crystalline
desmethylvenlafaxine
preparation
pharmaceutical composition
Prior art date
Application number
PCT/KR2011/004284
Other languages
English (en)
French (fr)
Other versions
WO2011155797A2 (ko
Inventor
박상국
임중인
한상덕
민종필
김정훈
장선우
황형돈
김순회
Original Assignee
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 동아제약 주식회사 filed Critical 동아제약 주식회사
Priority claimed from KR1020110056295A external-priority patent/KR20110135353A/ko
Publication of WO2011155797A2 publication Critical patent/WO2011155797A2/ko
Publication of WO2011155797A3 publication Critical patent/WO2011155797A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 용해도를 극대화시키고, 비흡습성을 나타내어 제약학적으로 바람직한 고형 물질의 물리화학적 특성을 갖는 결정형 O-데스메틸벤라팍신 헤미옥살레이트, 그의 제조방법 및 약제학적 조성물에 관한 것이다. 본 발명에 따른 결정형 O-데스메틸벤라팍신 헤미옥살레이트는 용해도가 높아 약물의 생체이용률을 증가시킬 수 있고, 조성물 크기에 제한없이 매우 용이하게 여러 제형을 설계할 수 있으며, 동물의 투여 한계 부피에 관계없이 약물을 고용량으로 투여 가능하므로 발현 가능한 독성을 확인하기에 용이하고, 흡습성이 적기 때문에 원료 유통 및 제제 생산에 적합하다.
PCT/KR2011/004284 2010-06-10 2011-06-10 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물 WO2011155797A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20100054937 2010-06-10
KR10-2010-0054937 2010-06-10
KR10-2011-0056295 2011-06-10
KR1020110056295A KR20110135353A (ko) 2010-06-10 2011-06-10 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물

Publications (2)

Publication Number Publication Date
WO2011155797A2 WO2011155797A2 (ko) 2011-12-15
WO2011155797A3 true WO2011155797A3 (ko) 2012-05-03

Family

ID=45098553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/004284 WO2011155797A2 (ko) 2010-06-10 2011-06-10 결정형 오-데스메틸벤라팍신의 헤미옥살레이트염, 그의 제조방법 및 그의 약제학적 조성물

Country Status (1)

Country Link
WO (1) WO2011155797A2 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2119695A1 (en) * 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
WO2010008735A2 (en) * 2008-06-16 2010-01-21 Teva Pharmaceutical Industries Ltd. Solid states of o-desmethylvenlaf axine salts
KR20100015923A (ko) * 2007-04-09 2010-02-12 세프라코 아이엔시. 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100015923A (ko) * 2007-04-09 2010-02-12 세프라코 아이엔시. 수면관련 호흡 장애를 치료하는 방법들 및 수면관련 호흡 장애 치료용 조성물들
EP2119695A1 (en) * 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
WO2010008735A2 (en) * 2008-06-16 2010-01-21 Teva Pharmaceutical Industries Ltd. Solid states of o-desmethylvenlaf axine salts

Also Published As

Publication number Publication date
WO2011155797A2 (ko) 2011-12-15

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