WO2011139110A2 - Dispositif d'injection d'insuline portatif de type stylo - Google Patents

Dispositif d'injection d'insuline portatif de type stylo Download PDF

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Publication number
WO2011139110A2
WO2011139110A2 PCT/KR2011/003368 KR2011003368W WO2011139110A2 WO 2011139110 A2 WO2011139110 A2 WO 2011139110A2 KR 2011003368 W KR2011003368 W KR 2011003368W WO 2011139110 A2 WO2011139110 A2 WO 2011139110A2
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WO
WIPO (PCT)
Prior art keywords
case
pusher
pusher housing
hole
housing
Prior art date
Application number
PCT/KR2011/003368
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English (en)
Korean (ko)
Other versions
WO2011139110A3 (fr
Inventor
최규동
강구민
Original Assignee
주식회사 디아메스코
투비엔스 주식회사
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Application filed by 주식회사 디아메스코, 투비엔스 주식회사 filed Critical 주식회사 디아메스코
Publication of WO2011139110A2 publication Critical patent/WO2011139110A2/fr
Publication of WO2011139110A3 publication Critical patent/WO2011139110A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/16—General characteristics of the apparatus with back-up system in case of failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the present invention relates to a pen-type portable insulin infusion device, and more particularly, to a pen-type portable insulin infusion device having an automatic / manual switching infusion function according to a user's selection.
  • a pen-type portable insulin injector that is compactly configured in the form of a pen and portable.
  • Diabetes is now known to be a common disease with about 200 million people worldwide, and complications and accompanying diseases associated with diabetes have emerged as one of the major health problems accompanied by human, social and economic losses.
  • Insulin is usually injected into a patient using an insulin syringe, an insulin pen, and an insulin pump.
  • Insulin syringe is the most common method for insulin administration, and it is very inexpensive to administer insulin, and it is easy to use and learn how to use.
  • the insulin pen is a device for injecting insulin contained in its cartridge, and there are many kinds of products and models. Most insulin pens are divided into two types: reusable pens and disposable pens. Insulin pen has advantages such as easy and convenient injection during going out compared to insulin syringe, and accurate dial amount can be injected by simple dial operation.
  • a method of manually injecting insulin such as U.S. Patent No. 5,308,340 (MULTIPLE DOSE INJECTION PEN) is disclosed, and U.S. Patent No. 6,942,646 (Inventive Name: PEN-TYPE).
  • U.S. Patent No. 6,942,646 Inventive Name: PEN-TYPE.
  • There is a literature that discloses how to inject insulin automatically such as INJECTOR HANING AN ELECTRONIC CONTROL UNIT.
  • Insulin pump is a medical device that acts as a pancreas and attaches to the patient's body to supply insulin appropriately to maintain normal blood sugar and to gradually restore pancreatic function. Insulin pumps inject insulin subcutaneously for 24 hours in a more sophisticated manner than insulin pens. Such insulin pumps have patents such as Korean Patent No. 723,808 (name of the invention: an automatic control insulin pump with a sensor), and No. 945,735 (name of the invention: a wireless control device for wirelessly controlling the insulin pump and the insulin pump). Disclosed in the literature.
  • Insulin pumps and insulin pens have the above advantages, but also have the following disadvantages.
  • Insulin pumps have the disadvantage that the device is relatively complex and therefore expensive because it requires 24 hours of subcutaneous injection of insulin. In addition, since it must be mounted on the body for 24 hours to limit the free activity, there is a problem that there is no way to inject insulin in the event of a failure.
  • Insulin pens are commonly used in the form of injecting insulin manually, such as US Patent No. 5,308,340, but most of these types of products are made for one-time use to inject insulin in the built-in insulin cartridge to the insulin pen. Since you have to throw away all the new insulin pens, there is a problem of wasting resources.
  • a product such as US Patent No. 6,942,646, which automatically injects insulin using a motor, it is impossible to inject insulin in an emergency such as when the battery is exhausted or the motor is broken. There is a problem that can be fatal to a patient.
  • An object of the present invention is to provide a pen-type portable insulin injecting device which can automatically inject the correct amount of insulin, exchange insulin cartridges, and inject insulin into the human body manually in an emergency.
  • the present invention is to provide a portable and compact insulin infusion device.
  • Pen-type portable insulin injection device is a device for injecting insulin into the human body by mounting a cartridge containing the insulin is an injection device capable of automatic / manual injection switching.
  • the pen-type portable insulin infusion device includes a case, a motor fixedly installed in the case, and a plurality of gears fixedly installed in the case and connected to a drive shaft of the motor to be engaged to transmit rotational force of the motor.
  • a drive unit including a gear box; A through hole is formed in the longitudinal direction and one end of the through hole is rotatably connected to the case, and one end is connected to the gear box so as to receive rotational force from the gear box and inserted into the through hole of the pusher housing.
  • a piston pushing unit including a mounted shaft and a pusher installed inside the through hole of the pusher housing and being pushed to receive a rotational force of the driving shaft to slide longitudinally within the through hole of the pusher housing;
  • the case and the pusher housing are restrained from the relative rotational movement and at the same time, the restraint of any one of the plurality of gears of the gearbox is transmitted so that the rotational force of the motor is transmitted to the electric shaft
  • Automatic / manual switching means for releasing the restraint so that the case and the fuser housing can perform relative rotational movement and at the same time restrain the rotation of any one of the plurality of gears of the gearbox such that the rotational force of the motor is not transmitted to the electric shaft; It is characterized by including.
  • the automatic / manual switching means may include a slide body constrainably slidable in the longitudinal direction with respect to the case and a case in which the case and the pusher housing do not rotate relatively at a first position where the slide body is moved in the pusher housing direction.
  • a connection switching means for separating the case and the pusher housing so that the pusher housing and the pusher housing are rotated relative to the case at a second position moved in the case direction. It is preferable to include a gear restraining means for restraining or releasing the rotation of the gear of the gearbox.
  • the slide body may be slidably installed by being fitted into the pusher housing in a ring shape having a predetermined length.
  • the connection switching means includes a guide groove formed in the longitudinal direction on one of the inner circumferential surface of the slide body and the outer circumferential surface of the pusher housing and a guide protrusion fitted in the guide groove in the other one, The guide protrusion in two positions can be configured to be separated from the guide groove.
  • the gear restraining means may include any one of a plurality of gears of the gear box and a restraining protrusion protruding from an end surface facing the case of the slide body to restrain rotation of any one of the plurality of gears of the gear box at the second position. It may be configured to include a restraint groove formed to be fitted to the restraining projection on the surface facing the pusher housing of the gear.
  • the piston pushing unit may further include a manual injection amount indicator and a manual injection amount limiting means in order to be able to inject the required amount when injecting insulin to the patient manually.
  • Manual injection amount indicator is a hollow ring shape, the pusher housing is inserted into the hollow rotatably installed, and the insulin injection amount display scale is displayed on the outer peripheral surface.
  • the manual injection amount limiting means limits the rotation angle of the case to the rotation angle of the manual injection amount indicator when the slider body is located at the second position.
  • the manual injection amount limiting means may be configured to include a stop projection protruding from an end surface of the manual injection amount indicator and a locking step formed to interfere with the stop projection on the inner circumferential surface of the case.
  • the pen-type portable insulin injection device forms a collar protruding annularly on the outer circumferential surface of one end of the pusher housing, the inner surface of the case to accommodate the collar to rotatably connect the pusher housing It can be rotatably connected to form a groove to prevent separation.
  • a screw thread is formed at the other end of the transmission shaft, and a screw thread for screwing the screw thread formed at the other end of the transmission shaft on the inner circumferential surface of the hollow cylindrical pusher may receive power from the transmission shaft.
  • the pusher is formed in one of the inner circumferential surface of the pusher housing and the outer circumferential surface of the pusher so as to be inserted into the through-hole of the pusher housing so as to be prolonged in the longitudinal direction to restrain the rotation of the pusher, and the other It is preferable to form the concave portion in the longitudinal direction so that the protrusion is inserted.
  • the slide body is in the first position in the automatic mode.
  • the slide body restrains the case and the pusher housing from relatively rotating, and at the same time, the gear restraining means releases the gear of the gearbox. Therefore, the rotational force of the motor can be transmitted to the transmission shaft through the gearbox to slide the pusher.
  • the pusher slides forward toward the cartridge, it pushes the piston of the insulin cartridge to inject insulin into the patient.
  • the slide body releases the restraint so that the case and the pusher housing can be rotated relatively in the second position and at the same time the gear restraint means Restrain the gear. Therefore, the gear of the gearbox is constrained to rotate integrally with the case, and when the case is rotated, an electric shaft connected to the gearbox rotates to slide the pusher. In other words, insulin can be injected into the patient by manually rotating the case.
  • Pen-type portable insulin injection device a case, a motor fixedly installed in the case, a plurality of fixedly installed in the case and connected to the drive shaft of the motor coupled to transfer the rotational force of the motor
  • a through hole is formed in the longitudinal direction and one end of the through hole is rotatably fixed to the case, and one end is connected to the gear box to receive rotational force from the gear box, and the through hole of the pusher housing.
  • a piston pushing unit including an inserted electric shaft and a pusher installed inside the through hole of the pusher housing and being constrained to slide longitudinally within the through hole of the pusher housing by receiving the rotational force of the electric shaft;
  • the gear box includes an idle gear having a plurality of rotation sensing holes arranged at regular intervals in the circumferential direction, the light emitting part and the light receiving part, and the light emitted from the light emitting part passes through the sensor hole of the idle gear.
  • An optical sensor installed to irradiate the light receiving unit; Characterized in that it comprises a.
  • the pen-type portable insulin injection device is easy to carry and can automatically inject the correct amount of insulin into the human body, can be used permanently by replacing the insulin cartridge, and the power supply drops or the motor is broken. In the event of an emergency, insulin can be injected into the body manually.
  • FIG. 1 is a schematic perspective view of one embodiment of a pen-type insulin infusion device according to the present invention.
  • FIG. 2 is a schematic exploded perspective view of the embodiment shown in FIG. 1.
  • FIG. 3 is a schematic exploded perspective view of the drive unit of the embodiment shown in FIG.
  • Figure 4 is a schematic exploded perspective view of the drive unit of the embodiment shown in Figure 1 seen from a different angle than FIG.
  • FIG. 5 is a schematic exploded perspective view of the gearbox of the embodiment shown in FIG.
  • FIG. 6 is a schematic perspective view of the gear box of FIG. 3 with the second and third supports removed.
  • FIG. 7 is a schematic exploded perspective view of the piston pushing unit of the embodiment shown in FIG.
  • FIG. 8 is a schematic exploded perspective view of the piston pushing unit of FIG. 2 viewed from an angle different from that of FIG. 7.
  • FIG. 9 is a schematic perspective view of the slide body of the automatic / manual switching means in the embodiment shown in FIG.
  • FIG. 10 is an explanatory view showing a state in which the second case is removed and the driving unit and the piston pushing unit are connected.
  • 11 is an operation explanatory diagram showing a method of injecting insulin manually.
  • FIG. 12 is a partial cross-sectional perspective view of another embodiment according to the present invention.
  • 'upper' or 'upper side' means a direction in which a distal end of the driving unit 100 is located
  • 'lower' or 'lower side' means a piston. Means the direction in which the distal end of the pushing unit 200 is located.
  • the pen-type insulin injector of this embodiment includes a drive unit 100, a piston pushing unit 200, and automatic / manual switching means.
  • the drive unit 100 has a built-in battery and is coupled with the piston pushing unit 200 to transmit the rotational force of the motor to the piston pushing unit 200 through the gear box.
  • the piston pushing unit 200 includes a cartridge fixing body 260, and the cartridge 1 containing insulin is detachably mounted to the cartridge fixing body 260.
  • the cover 201 is inserted into the piston pushing unit 200 to protect the device.
  • the driving unit 100 and the piston pushing unit 200 have a collar 212 of the pusher housing 210 formed on the inner circumferential surfaces of the first case 111 and the second case 112. Is inserted into the collar groove 127 is connected to the rotation is possible, but is constrained to be unable to move in the longitudinal direction.
  • the drive unit 100 is constrained so as not to rotate with respect to the piston pushing unit 200, or the restriction is released to enable rotation. Detailed description thereof will be described later.
  • the driving unit 100 includes a case, a motor 130, a control unit 140, a display unit 150, and a gear box 160.
  • the case is formed by assembling the divided first case 111, the second case 112, the third case 113, and the fourth case 114. Inside the assembled case, the motor 130, the controller 140, the display unit 150, and the gear box 160 are fixed to the cabinet.
  • a USB connection hole 115 is formed in the first case 111.
  • the USB connection hole cover 116 for closing the USB connection hole 115 is detachably installed.
  • the operation button hole 117 is formed in the second case 112. Since there are three operation buttons 141 in the present embodiment, three operation button holes 117 are formed.
  • the first case 111 and the second case 112 are coupled to each other at the lower portion, and when combined, the injection amount checking hole 118 is formed.
  • the injection amount confirmation hole 118 is fitted with a hole cover 119 for injection amount confirmation of a transparent plastic or glass material.
  • the third case 113 is provided with a display hole 120 that allows the display unit 150 to be viewed from the outside.
  • the fourth case 114 is provided with an operation button hole 121 for exposing the operation button 142 to the outside.
  • the third case 113 and the fourth case 114 are coupled to each other with the control unit 140 and the display unit 150 therein, and after the coupling, the third case 113 and the fourth case 114 are sandwiched between the first case 111 and the second case 112. Is fixed.
  • the semi-circular manual operation hole 122 is formed by the first case 111, the second case 112, and the third case 113. .
  • the manual manipulation hole 122 is attached to the manual manipulation hole cover 123 that can be opened and closed.
  • the controller 140 controls the rotation of the motor 130, so that the drive shaft of the motor 130 is connected to the gearbox 160.
  • the battery 144 for supplying power to the motor 130 and the control unit 140 is installed on the side of the control unit 140.
  • the controller 140 receives the information input by the user and processes the information to drive the motor 130.
  • the controller 140 receives a command from the operation button 141 exposed to the outside, and information on this is displayed on the display unit 150.
  • the control unit 140 is connected to the operation button 142, USB connector 143 for transmitting information to or from the outside is connected.
  • the display unit 150 receives the information about the insulin injection, that is, the information about the insulin injection amount, the injection time, and the like from the control unit 140 and uses the LCD to display the external information.
  • the gear box 160 receives the rotational force of the motor 130 and transmits the rotational force to the electric shaft 230 at a predetermined reduction ratio.
  • the gear box 160 includes a first spur gear 161 connected to a drive shaft of the motor 130, a first double spur gear 164, an idle gear 165, a second double spur gear 168, And a third double spur gear 171 and a second spur gear 172.
  • the first spur gear 161 is engaged with the upper gear 162 of the first double spur gear 164, and the idle gear 165 is engaged with the lower gear 163 of the first double spur gear 164. Lose.
  • the idle gear 165 meshes with the upper gear 166 of the second double spur gear 168
  • the lower gear 167 of the second double spur gear 168 is the third double spur gear 171.
  • the upper gear 169 of the and teeth are meshed.
  • the second spur gear 172 meshes with the lower gear 170 of the third double spur gear 171 and is connected to the transmission shaft 230.
  • Rotational force of the motor 130 is the first spur gear 161, the first double spur gear 164, the idle gear 165, the second double spur gear 168, the third double spur gear 171, the second The spur gear 172 is transmitted in order.
  • the reduction ratio of the gear box 160 is the tooth ratio of the upper gear 162 of the first spur gear 161 and the first double spur gear 164, the upper gear 164 of the first double spur gear 164.
  • the idle gear 165 does not affect the reduction ratio.
  • the idle gear 165 is formed with a plurality of rotation detection holes 176 at regular intervals along the circumferential direction.
  • the gearbox 160 has a light emitting unit 174 and a light receiving unit 175, and the light emitted from the light emitting unit 174 passes through the rotation sensing hole 176 of the idle gear 165 to receive the light receiving unit 175.
  • An optical sensor 173 is installed to radiate to the light. The optical sensor 173 detects a signal for the rotation of the idle gear 165 and transmits the signal to the controller 140.
  • the lower surface of the upper gear 169 of the third double spur gear 171 is formed with a plurality of projections 176 at regular intervals so that a plurality of restraint grooves are formed in the circumferential direction.
  • a restraint protrusion 301 of the slide body 300 is fitted into the restraint groove formed by the protrusions 176 arranged at regular intervals to restrain the rotation of the gear.
  • a thread 303 is formed on the end surface of the restraining protrusion 301 to be engaged with the protrusion 176 of the upper gear 167. Detailed description of these operations will be described later.
  • the gears and the optical sensor of the gearbox 160 are positioned by the first gear support 177, the second gear support 178, and the third gear support 179.
  • a plurality of gear support shafts 180 are formed in the first gear support portion 177, and the ends of the gear support shafts 180 are fitted to the second gear support portion 178 or the third gear support portion 179 to be fixed. do.
  • a pair of slide body guides 181 protrude from the lower surface of the third gear support portion 179.
  • the third gear support part 179 is provided with a restriction protrusion passage hole 182 through which the restriction protrusion 301 of the slide body 300 passes.
  • the piston pushing unit 200 receives the rotational force from the drive unit 100, and functions to convert the pusher 240 to pressurize the piston of the cartridge 10 by linear movement.
  • the piston pushing unit 200 includes a pusher housing 210, a transmission shaft 230, and a pusher 240.
  • a manual injection dose indicator 250 is fitted to the pusher housing 210, and a cartridge connector 220 is fixed to the lower end of the pusher housing 210.
  • the manual injection amount indicator 250 is fitted to the pusher housing 210 so as to be rotatable.
  • the pusher housing 210 has a hollow cylindrical shape having a through hole in the longitudinal direction, and a pair of slide protrusions 211 protruding in the longitudinal direction are formed on the inner circumferential surface thereof.
  • the slide protrusion 211 is for guiding the pusher inserted into the hollow to perform a linear movement without rotating.
  • a collar (COLLAR) 212 protruding annularly is formed on the outer circumferential surface of the upper end of the pusher housing 210.
  • a plurality of protrusions 214 are formed at equal intervals in the circumferential direction on the lower surface of the collar 212 of the pusher housing 210.
  • the collar 212 of the pusher housing 210 is inserted into the collar groove 127 formed on the inner circumferential surfaces of the first case 111 and the second case 112 to connect the pusher housing 210 and the driving unit 100. .
  • the collar 212 is inserted into the collar groove 127 to couple the pusher housing 210 and the driving unit 100 so as to be rotatable without being separated in the longitudinal direction.
  • a manual injection amount indicator 250 and a slide body 300 are fitted to each other, and their structure and operation will be described later.
  • the upper end 231 of the transmission shaft 230 is inserted into the second spur gear 172 of the gear box 160 and fixed to receive the rotational force.
  • a screw 232 is formed on the outer circumferential surface of the lower end of the transmission shaft 230.
  • the transmission shaft 230 is inserted into the hollow of the pusher 240, the screw 232 of the lower end is engaged with the screw formed on the inner peripheral surface of the pusher 240.
  • the pusher 240 inserted into the hollow of the pusher housing 210 is linearly moved so that the rotational movement is constrained.
  • the pusher 240 has a hollow cylindrical shape and a screw for screwing with the screw 232 of the transmission shaft is formed on the inner circumferential surface of the hollow.
  • the outer peripheral surface of the pusher 240 is inserted into the hollow of the pusher housing 210, a pair of slide grooves 241 for accommodating the slide projection 211 is formed in the longitudinal direction.
  • the pusher 240 is inserted so that the slide protrusion 211 and the slide groove 241 is engaged when it is inserted into the hollow of the pusher housing 210, the rotational movement is constrained and constrained so that only linear movement in the longitudinal direction is possible. .
  • the manual injection amount indicator 250 has a hollow cylindrical shape and is rotatably fitted to the outer circumferential surface of the pusher housing 210.
  • On the upper side of the outer circumferential surface of the injection amount display unit 250 is provided with an injection amount display unit 251 displayed at equal intervals in the insulin injection amount according to the rotation angle, and a handle portion 252 is formed on the lower side to facilitate the user's rotation.
  • the stopper 253 is formed to protrude in the longitudinal direction on the upper end surface.
  • the cartridge connector 220 is inserted into the pusher housing 210 and fixed to the lower portion of the injection amount indicator 250.
  • the cartridge holder 260 is detachably coupled to the cartridge connector 220 with screws, and accommodates the cartridge 1 containing insulin. On the outer circumferential surface of the cartridge holder 260, a residual amount confirmation hole 261 for confirming the residual amount of insulin of the cartridge 1 accommodated is formed.
  • the needle connector 270 is fixed to the lower side of the cartridge holder 260 and detachably coupled with a screw.
  • the automatic / manual switching means among the plurality of gears of the gear box 160 to restrain the case and the pusher housing 210 from the relative rotational movement in the first position and at the same time the rotational force of the motor is transmitted to the transmission shaft 230 Release the restraint of either gear.
  • the automatic / manual switching means a plurality of gearboxes to release the restraint so that the case and the fuser housing 210 in the second position to perform a relative rotational movement and at the same time prevent the rotational force of the motor to be transmitted to the electric shaft 230 Constrain the rotation of any one of the gears.
  • Automatic / manual switching means having the above function, the slide body 300, the connection switching means for connecting or separating the case and the pusher housing, and the sliding of the slide body in conjunction with the sliding of the gear box to rotate the gears Gear restraining means for restraining or releasing restraints.
  • the slide body 300 is restrained so that sliding in the longitudinal direction with respect to a case is possible.
  • the slide body 300 is fitted to the upper side of the collar 212 of the pusher housing 210 in a ring shape having a predetermined length so as to be slidable in the longitudinal direction.
  • a pair of guide grooves 302 are formed in the longitudinal direction on the inner circumferential surface of the slide body 300.
  • a pair of guide protrusions 213 are formed on the upper side surface of the pusher housing 210 facing the case of the collar 212 so as to protrude upward.
  • a constraining protrusion 301 protruding upward is formed on the upper end surface of the slite body 300 facing the case.
  • the restraint protrusion 301 is inserted into the restraint groove formed by the protrusion 176 arranged at a predetermined interval on the lower side of the upper gear 169 of the third double spur gear 171 so that the third double spur gear 171 is provided. Should not rotate.
  • the end surface of the restraint protrusion 301 is formed with a thread 303 to be engaged with the protrusion 176 of the upper gear 167 to increase the restraint force.
  • the connection switching means connects the case and the pusher housing 210 so that the slide body 300 does not rotate relative to the case and the pusher housing 210 at the first position, and the pusher housing 210 is the case at the second position. It functions to separate the case and the pusher housing so that it can rotate relative to.
  • connection switching means is composed of a pair of guide grooves 302 formed on the inner circumferential surface of the slide body 300 and guide protrusions 213 formed on the pusher housing 210.
  • Guide protrusion 213 is to be separated from the guide groove 302 in the second position, the pusher housing 210 is rotatable with respect to the case.
  • the gear restraining means is provided on the projections 176 arranged at regular intervals on the lower surface of the restraining protrusion 301 of the slide body 300 and the upper gear 169 of the third double spur gear 171. Consists of a restraint groove formed by.
  • the restraining protrusion 301 is inserted into the gearbox 160 through the locking hole 182 formed in the third gear support 179.
  • the restraining protrusion 301 is inserted into the restraining groove of the third double spur gear 171 at the second position to restrain the third double spur gear 171 from rotating.
  • the pair of guide protrusions 213 of the pusher housing 210 in the first position is inserted from the lower portion of the pair of guide grooves 302 of the slide body 300 so that the slide body 300 and the pusher housing 210. ) Is constrained to rotate integrally.
  • a pair of slide body guide protrusions 181 formed on the bottom surface of the third gear support portion 179 of the gear box 160 also has a corresponding pair of guide grooves 302 of the slide body 300 at an upper portion thereof. Inserted to restrain the gearbox 160 and the slide body 300 to be integrally rotated. That is, in the first state, the driving unit 100 and the piston pushing unit 200 are restrained from relatively rotating, and when the rotation of the motor rotates, the pusher 240 slides with respect to the pusher housing 210.
  • the pair of guide protrusions 213 of the pusher housing 210 are separated from the pair of guide grooves 302 of the slide body 300. That is, the driving unit 100 and the piston pushing unit 200 are released to restrain integrally to be in a relatively rotatable state.
  • the restraining protrusion 301 of the slide body 300 rises to restrain the third double spur gear 171 from rotating. That is, when the driving unit 100 is rotated with respect to the piston pushing unit 200 in the second position, the electric shaft 230 rotates together with the driving unit 200, and the pusher 240 is connected to the pusher housing 210. To slide.
  • FIG. 10 is an explanatory view showing a part in which the second case is removed and the driving unit 100 and the piston pushing unit 200 are connected
  • FIG. 11 is an insulin in case of an emergency such as when a motor breaks down or a battery is exhausted. It is explanatory drawing explaining the method of using an injection device manually.
  • Normally refers to a case in which the motor 130 operates normally.
  • the controller may control the rotation of the motor 130 to inject insulin to the desired amount.
  • the slide body 300 is located at the first position, and the driving unit 100 and the piston pushing unit 200 are restrained from being relatively rotatable.
  • the slide protrusion 300 is pushed downward to the lower side so that the fixing protrusion 213 of the pusher housing 210 fits into the fixing groove 302 of the slide body 300.
  • the restraining protrusion 301 is located at a position where the third double spur gear 171 of the gearbox 160 is not restrained (locked). This state is called a 'first position' state.
  • the pusher housing 210 is connected to the driving unit 100 through the slide body 300 so that the slide unit 300 does not rotate relatively. This is because the guide protrusion 213 and the slide body guide protrusion 181 are inserted into the guide groove 302 at the same time.
  • the power of the motor 120 may be transmitted to the transmission shaft 230 through the gearbox 160.
  • a limiting jaw 124 is formed inside the hole cover 123 for manual operation so as to restrict the slide body 300 from moving upward. When the hole cover 123 for manual operation is closed, The slide body 300 may be fixed to the first position by being caught by the jaw 124.
  • the emergency refers to a case in which the motor 130 does not operate, such as when the battery is exhausted or the controller 140 is broken.
  • insulin may be injected by manually rotating the driving unit 100.
  • the guide protrusion 213 is deviated from the guide groove 302 by pushing the slide body 300 to the upper side as much as possible, and at the same time, the restraining protrusion 301 is a gearbox ( It is inserted into the inside of the 160, so that the screw 303 formed on the end surface of the restraining protrusion 301 is engaged with the protrusion 176 formed on the third double spur gear 171.
  • This state is called a "second position" state.
  • the drive unit 100 may be relatively rotated with respect to the piston pushing unit 200, and the gear of the gear box 160 may not rotate.
  • the slide body guide protrusion 181 formed on the lower side of the third gear support 179 is always inserted into the guide groove 302, when the slide body 300 is moved from the first position to the second position.
  • the slide body 300 is guided to be moved along the slide body guide protrusion 181 without rotating.
  • the slide body guide protrusion 181 is inserted into the guide groove 302 in the first position or the second position, so that the slide body 300 is always in the longitudinal direction without rotational movement with respect to the drive unit 100. Only go.
  • the hole cover 123 for manual operation is opened.
  • the slide body 300 is pushed upward to be positioned at the second position, and then the slide cover 300 is closed by closing the hole cover 123 for manual operation. Lock it back to the first position.
  • the manual injection amount indicator 250 is turned clockwise so that the desired injection amount is displayed in the injection amount confirmation hole 118.
  • the stop projection 253 of the manual injection amount indicator 250 is elastically in contact with the protrusion 214 of the pusher housing 210 to rotate by a predetermined angle interval to determine the desired injection amount It is convenient to
  • the driving unit 100 After inserting the injection needle into the skin for insulin injection, as shown in (d) of FIG. 11, the driving unit 100 is rotated until the value shown in the injection amount checking hole 118 becomes 0. Inject insulin by the amount.
  • the elastic protrusion 125 formed on the inner circumferential surface of the first case 111 may include the protrusion 214 formed on the lower side surface of the collar 212 of the pusher housing 210. Since it is to rotate while the elastic contact, it can be rotated by the interval of a predetermined angle when rotating the drive unit (100).
  • the embodiment illustrated in FIG. 12 is different from the embodiment illustrated in FIG. 1, instead of the elastic protrusions 125 formed on the first case 111, the elastic protrusions 125-1_ are formed on the third gear support part 179. And the concave-convex (214-1) is formed on the upper end surface of the pusher housing 120, so that the elastic projection (125-1) elastic contact with the concave-convex (214-1) when rotating the drive unit for manual injection It is a point that can be rotated by a predetermined angle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention a pour objet un dispositif d'injection d'insuline portatif de type stylo, et plus particulièrement un dispositif d'injection d'insuline portatif de type stylo ayant une fonction d'injection automatique / manuelle qui est commutée au gré de l'utilisateur. Le dispositif d'injection d'insuline portatif de type stylo selon la présente invention comporte une unité de commande, une unité à piston-poussoir et des moyens de commutation d'injection automatique / manuelle. L'unité à piston-poussoir comporte : un logement de poussoir qui possède un trou traversant constitué dans une direction longitudinale et qui est relié de façon pivotante à un boîtier ; un arbre de transmission dont une extrémité est reliée à une boîte d'engrenages de sorte à recevoir le couple de rotation de la boîte d'engrenages et qui est insérée dans le trou traversant du logement du poussoir ; et un poussoir installé et contenu dans le trou traversant du logement du poussoir de sorte que le poussoir reçoive le couple de rotation de l'arbre de transmission et coulisse dans une direction longitudinale à l'intérieur du trou traversant du logement du poussoir. Les moyens de commutation d'injection automatique / manuelle évitent, dans une première position, que le boîtier et le logement du poussoir n'empêchent une rotation relative entre le boîtier et le logement du poussoir et libèrent aussi l'un quelconque de la pluralité d'engrenages de la boîte d'engrenages de sorte à permettre au couple de rotation d'un moteur d'être transmis à l'arbre de transmission. Les moyens de commutation d'injection automatique / manuelle rendent possible, dans une seconde position, que le boîtier et le logement du poussoir permettent une rotation relative entre le boîtier et le logement du poussoir et aussi empêchent la rotation de l'un quelconque de la pluralité des engrenages de la boîte d'engrenages de sorte à empêcher le couple de rotation du moteur d'être transmis à l'arbre de transmission.
PCT/KR2011/003368 2010-05-04 2011-05-04 Dispositif d'injection d'insuline portatif de type stylo WO2011139110A2 (fr)

Applications Claiming Priority (2)

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KR20100041625 2010-05-04
KR10-2010-0041625 2010-05-04

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WO2011139110A3 WO2011139110A3 (fr) 2012-04-26

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KR101462438B1 (ko) * 2013-11-07 2014-11-17 주식회사 메가젠임플란트 약물 주입 장치
CN112714654A (zh) * 2018-09-20 2021-04-27 阿普塔尔法国简易股份公司 自动注射器
CN112755332A (zh) * 2020-12-29 2021-05-07 查维祎 一种流体输注系统及其使用方法
CN113730729A (zh) * 2021-09-13 2021-12-03 深圳瑞宇医疗科技有限公司 一种手电动一体胰岛素注射笔及其注射方法
WO2022010726A1 (fr) * 2020-07-09 2022-01-13 Eli Lilly And Company Dispositif d'injection automatique à partie réutilisable
WO2023150090A1 (fr) * 2022-02-03 2023-08-10 Eli Lilly And Company Dispositif d'administration d'agent thérapeutique à entraînement unique par moteur

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KR101404847B1 (ko) * 2012-05-04 2014-06-11 김종훈 펜형 약물 주입 장치
KR101396224B1 (ko) * 2012-08-30 2014-05-19 주식회사 에스에프에이 평면 디스플레이용 필름 분리장치
KR20180032825A (ko) * 2016-09-23 2018-04-02 최규동 산소포화도 및 심박 측정이 가능한 인슐린 주입기
KR101958067B1 (ko) * 2016-12-27 2019-07-04 최규동 펜형 주사장치의 범용 장착형 투입량 측정 및 관리 시스템
KR20200032308A (ko) 2018-09-18 2020-03-26 최규동 휴대형 자동 주사 장치의 카트리지 고정 가이드 구조
KR20200032310A (ko) 2018-09-18 2020-03-26 최규동 휴대형 자동 주사 장치의 구동 연결 클러치 구조
KR101992165B1 (ko) 2018-11-23 2019-09-30 이대로 자동 인슐린 주입장치
KR102081054B1 (ko) 2019-06-19 2020-02-25 이대로 자동 인슐린 주입 장치
KR102204634B1 (ko) 2020-09-23 2021-01-19 이대로 인슐린 주입 장치
KR20230042607A (ko) 2021-09-22 2023-03-29 안영환 펜형 주사장치의 커버형 온도유지시스템
KR20230088618A (ko) 2021-12-10 2023-06-20 이대로 인슐린　주입　장치

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CN112714654B (zh) * 2018-09-20 2023-03-28 阿普塔尔法国简易股份公司 自动注射器
CN112714654A (zh) * 2018-09-20 2021-04-27 阿普塔尔法国简易股份公司 自动注射器
WO2022010726A1 (fr) * 2020-07-09 2022-01-13 Eli Lilly And Company Dispositif d'injection automatique à partie réutilisable
US20230191032A1 (en) * 2020-07-09 2023-06-22 Eli Lilly And Company Automatic injection device with reusable portion
US11850402B2 (en) 2020-07-09 2023-12-26 Eli Lilly And Company Automatic injection device with reusable portion
CN112755332A (zh) * 2020-12-29 2021-05-07 查维祎 一种流体输注系统及其使用方法
CN112755332B (zh) * 2020-12-29 2022-06-03 查维祎 一种流体输注系统
CN113730729A (zh) * 2021-09-13 2021-12-03 深圳瑞宇医疗科技有限公司 一种手电动一体胰岛素注射笔及其注射方法
CN113730729B (zh) * 2021-09-13 2023-08-18 郑州瑞宇科技有限公司 一种手电动一体胰岛素注射笔及其注射方法
WO2023150090A1 (fr) * 2022-02-03 2023-08-10 Eli Lilly And Company Dispositif d'administration d'agent thérapeutique à entraînement unique par moteur

Also Published As

Publication number Publication date
WO2011139110A3 (fr) 2012-04-26
KR101217147B1 (ko) 2012-12-31
KR20110122647A (ko) 2011-11-10

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