WO2011118958A2 - 수중유형 나노 에멀젼 조성물 및 이의 제조방법 - Google Patents
수중유형 나노 에멀젼 조성물 및 이의 제조방법 Download PDFInfo
- Publication number
- WO2011118958A2 WO2011118958A2 PCT/KR2011/001953 KR2011001953W WO2011118958A2 WO 2011118958 A2 WO2011118958 A2 WO 2011118958A2 KR 2011001953 W KR2011001953 W KR 2011001953W WO 2011118958 A2 WO2011118958 A2 WO 2011118958A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oil
- composition
- polyol
- emulsion
- nanoemulsion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
Definitions
- the present invention relates to a nano-sized low viscosity oil-in-water emulsion composition, a cosmetic composition comprising the same, and a method for preparing the same using an O / P (polyol-in-oil) emulsion method.
- An emulsion refers to a liquid-liquid dispersion system in which one or more liquid phases are dispersed, which are not mixed in one liquid phase, and generally have a size distribution of several micrometers to several tens of micrometers.
- Macroemulsions with these particle sizes are thermodynamically unstable and are eventually separated by various pathways such as floculation, sedimentation, creaming, ostwald ripening and coalescence. It has a nature to be.
- the stability of the emulsion in the kinetic aspect can be greatly improved by the brown motion between the particles, and a low viscosity emulsion having a high content of the inner phase can be prepared. Because of this, not only can make cosmetics with a variety of feeling, but also has a small particle size can effectively deliver the active ingredient to the skin.
- liquid-liquid dispersion systems in which the average diameter of the dispersed phase particles is 20-500 nm, although slightly different according to the literature, are used in nanoemulsions (Flockhart, IR etc, Nanoemulsions derived from lanolin show promising drug delivery properties, J. Pharm.pharmacol. , 50 (Supplement) 1998, 141).
- the hydrogen bond between ethylene oxide, which is a hydrophilic group of a nonionic surfactant, and water decreases as the temperature increases in a composition composed of water, oil, and a nonionic surfactant. It is an emulsification method using the principle.
- the composition composed of the three-component system forms an O / W emulsion at a certain temperature or less and a W / O emulsion at a certain temperature or more. This temperature is called the "Phase Inversion Temperature".
- the high-pressure emulsification method is a method of nanoparticles by passing the particles through a high-pressure emulsification apparatus applying a strong shear at 1000 to 1500 atmospheres.
- These high pressure emulsifiers are most commonly used microfluidizer (U.S.Patent 4533254) to apply more than 1000 atm.
- the present invention is to provide a low viscosity white oil-in-water (O / W) nano-emulsion composition and a cosmetic composition comprising the same, which was not specifically implemented by the prior art, to prepare an oil-in-water nano-emulsion composition
- a low viscosity white oil-in-water (O / W) nano-emulsion composition and a cosmetic composition comprising the same, which was not specifically implemented by the prior art, to prepare an oil-in-water nano-emulsion composition
- One embodiment according to the invention is an oil phase component comprising an oil and a polyethylene glycol ester-based emulsifier; And it relates to an oil-in-water (O / W) nano emulsion composition comprising an aqueous phase component comprising a polyol or polyol derivative.
- Another embodiment according to the present invention relates to a cosmetic composition comprising the nano-emulsion composition.
- Another embodiment according to the present invention comprises the steps of heating an oil phase component comprising an oil and a polyethylene glycol ester-based emulsifier; Heating the polyol or polyol derivative; Injecting the oil phase component into the polyol or polyol derivative to form a polyol-in-oil (O / P) gel; Adding and stirring an aqueous phase component to the polyol-in-oil gel; And it relates to a method for producing an oil-in-water nano emulsion composition comprising the step of cooling the stirred component.
- a nano-sized low-viscosity emulsion having a high content of an inner phase can be provided through a method different from the conventional full-phase temperature emulsification method or a high-pressure emulsification method, thereby greatly improving the stability of the emulsion.
- the nanoemulsion composition according to the present invention can be applied to a variety of cosmetic compositions, it is possible to prepare a cosmetic composition with a variety of feeling, as well as the advantage of effectively delivering effective ingredients to the skin small particle size have.
- the emulsion is not particularly limited as long as it has a low viscosity to achieve the desired dispersibility in order to increase the content of the internal phase and effectively deliver the active ingredient, for example, 4000 cps or less, specifically It may have a viscosity of 2000 cps or less, more specifically 1000 cps or less.
- the emulsion of 'low viscosity' includes all the emulsions belonging to the aforementioned viscosity range from the case where the viscosity is so small that the viscosity cannot be measured experimentally, and the viscosity range is 0 when the viscosity is not measured experimentally. For example, it may have a viscosity of 0 to 4000 cps, specifically 1 to 2000 cps, more specifically 5 to 1000 cps.
- the emulsion has a nano-size is not particularly limited as long as it can produce a low viscosity emulsion while improving the stability of the emulsion, for example, the average size may be 500nm or less, specifically 300nm or less have.
- the emulsion may have any size that falls within the above average size range, but may have, for example, an average size of 10 to 500 nm, specifically 50 to 300 nm.
- the particle size distribution may be very narrow, for example 10 ⁇ 800nm, specifically 100 ⁇ 600nm, through which not only excellent in terms of stability, but also can provide a light nano-emulsion composition in terms of use.
- the emulsion composition may exhibit a white color, specifically, may represent a creamy feeling of cloudiness.
- a nano-emulsion according to the conventional phase-phase emulsification method as disclosed in Comparative Example 2 below although it may have a translucent blueish appearance, it may express an appearance exhibiting a creamy feeling of turbidity. There was no number.
- the emulsion composition according to the present invention can exhibit a visually exaggerated appearance with a white, in particular white, creamy feeling.
- composition according to the present invention comprises an oil and a polyethylene glycol ester emulsifier as an oil phase component, and includes a polyol or a polyol derivative as an aqueous phase component.
- the polyethyleneglycol ester-based emulsifier is not particularly limited as long as it is commonly used in the preparation of oil-in-water emulsion composition, for example, p-n glyceryl having a polymerization degree of 3 to 90, preferably a polymerization degree of 3 to 60.
- p-n glyceryl having a polymerization degree of 3 to 90, preferably a polymerization degree of 3 to 60.
- Two or more fiji-n glyceryl isostearates which may be isostearate and differ in the degree of polymerization, in a predetermined ratio, for example, 1 to 5: 1 to 1: 1 to 5, specifically 1 to 3: 1 to 1: You may mix and use in the ratio of 1-3.
- the emulsifier may be included in 0.1 to 20% by weight, specifically 0.1 to 10% by weight based on the total weight of the composition. If the amount exceeds 10% by weight, the viscosity is too high because it does not match the blending ratio of the oil phase portion, and if it is less than 0.1% by weight, the emulsifying power is reduced, so that emulsified particles are formed too large, so that the emulsion stability is not good.
- the oil is not particularly limited as long as it is conventionally used in preparing an oil-in-water emulsion composition, for example, a group consisting of silicone oil, ester oil, hydrocarbon oil and mixtures thereof. It may be one or more selected from.
- the at least one oil selected from the group consisting of silicone oils, ester oils, hydrocarbon oils and mixtures thereof is, for example, triethylhexanoin, dimethicone, cetyloctanoate, dicaprylate and dicaprate , Isopropyl myristate, tocophenolacetate and at least one selected from the group consisting of caprylic and capric triglycerides.
- the oil may be included in 0.1 to 40% by weight, specifically 1 to 20% by weight based on the total weight of the composition.
- oil content refers to the total amount of the oil phase components that do not include an emulsion stabilizer, when the oil content is less than 1% by weight, the moisturizing feeling and emollient feeling is lowered, the usability is reduced, If it exceeds 20% by weight, the emulsion particles may become large, resulting in poor emulsion stability.
- the composition according to the present invention may further include a pigment, a flavor, a preservative or a thickener as an auxiliary component used in preparing the oil-in-water nanoemulsion composition, wherein the content of the auxiliary component is, for example It may be from 0 to 20% by weight based on the total weight of the composition.
- the polyol or polyol derivative is an aqueous component, and may be included as long as it is suitable for the production of low-viscosity nanoemulsion, and may be, for example, one or more selected from the group consisting of glycerin, monovalent or divalent alcohols, and mixtures thereof. .
- the polyol or polyol derivative included in the composition according to the present invention may be, for example, a mixture of glycerin and butylene glycol, a dihydric alcohol, but is not limited thereto.
- the present invention also relates to a cosmetic composition comprising the nanoemulsion composition.
- the cosmetic composition according to the present invention is not particularly limited in the formulation, but can be used on the skin, mucous membranes, scalp or hair, for example, soft cosmetics, nutrient cosmetics, lotions, creams, packs, gels, patches or sprays ( Basic cosmetics such as mist); Color cosmetics such as lipstick, makeup base or foundation; Cleaning agents such as shampoo, rinse, body cleanser, toothpaste or mouthwash; Hair dressing agents such as hair tonic, gel or mousse; Or it may be formulated into a cosmetic composition for hair, such as wool or hair dye. It can also be widely applied to pharmaceuticals and quasi-drugs such as lotions, ointments, gels, creams, patches or sprays.
- the present invention further comprises the steps of heating an oil phase component comprising an oil and a polyethylene glycol ester-based emulsifier; Heating the polyol or polyol derivative; Injecting the oil phase component into the polyol or polyol derivative to form a polyol-in-oil (O / P) gel; Adding and stirring an aqueous phase component to the polyol-in-oil gel; And it relates to a method for producing an oil-in-water nano emulsion composition comprising the step of cooling the stirred component.
- phase-temperature emulsification method only the polyoxyethylene (polyoxyethylene, POE) -based compound commonly used as a nonionic surfactant in the phase-phase emulsification method has a problem that the phase-phase temperature is low around room temperature to about 60 ° C., resulting in poor stability. do.
- the temperature rises under the conditions of storage or movement, or it may be stored and distributed in a high temperature place. Therefore, when the phase temperature is low, the O / W-type nanoemulsion may be unstable and easily separated.
- the above method may have a translucent blueish appearance by the nanoparticles, but cannot express a white or milky white highly concentrated appearance.
- the manufacturing method according to the present invention is different from the conventional manufacturing method as described above, O / P (polyol in the middle type) by using a polyethylene glycol ester emulsifier according to the emulsification method O / It is to prepare a W-type nanoemulsion composition.
- O / P polyol in the middle type
- Nanoparticles were made at 1000 atmospheres using a microfluidizer (U.S.Patent 4533254).
- Creams or oils stored for 5 days, 10 days, 15 days and one month in room temperature, 45 ° C. and Cycling thermostat, using O / W cosmetics prepared in Comparative Examples 1 to 3 and Example 1 as test substances. Emulsion stability was observed depending on the occurrence of separation and the like, the results are shown in Table 3 below.
- the O / W type nanoemulsion of Example 1 according to the present invention can secure higher stability than the O / W type emulsions of Comparative Examples 1 to 3 at room temperature, high temperature, and circulating state. . That is, when preparing an O / W type nanoemulsion, a low viscosity water-in-oil type turbid emulsion having a stable nano size can be prepared by using an O / P (polyol-in-oil type) emulsion method.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
Abstract
Description
배합성분 | 비교예1 | 비교예2 | 비교예3 | 실시예1 | |
유상성분 | 트리에칠헥사노인 | 2 | 2 | 2 | 2 |
세틸 에틸헥사노에이트 | 2 | 2 | 2 | 2 | |
디메티콘 | 3 | 3 | 3 | 3 | |
세테아릴 알코올 | 0.3 | 0.3 | 0.3 | 0.3 | |
포리그릴세릴-3 메칠글루코스 이스테아레이트 | 1.5 | 0 | 0 | 0 | |
피이지-100 스테아레이트 | 0.5 | 0 | 0 | 0 | |
세테아레스-12 | 0 | 1.5 | 0 | 0 | |
세테아레스-20 | 0 | 0.5 | 0 | 0 | |
피이지-5 레이프씨드 스테롤 | 0 | 0 | 1.5 | 0 | |
하이드로제네이티드 레시틴 | 0 | 0 | 0.5 | 0 | |
피이지-20 글리세릴 이소스테아레이트 | 0 | 0 | 0 | 1.5 | |
피이지-40 글리세릴 이소스테아레이트 | 0 | 0 | 0 | 0.5 | |
수상성분 | 정제수 | 잔량 | 잔량 | 잔량 | 잔량 |
글리세린 | 2 | 2 | 2 | 2 | |
부틸렌글리콜 | 4 | 4 | 4 | 4 |
비교예 1 | 비교예 2 | 비교예 3 | 실시예 1 | |
입자사이즈(평균) | 12㎛ | 250nm | 280nm | 275nm |
점도(cps) | 8700 | 120 | 80 | 150 |
외관 | 유백색 | bluish | 현탁 | 백색 |
비교예 1 | 비교예 2 | 비교예 3 | 실시예 1 | ||
실온 | 5일 | 양호 | 양호 | 양호 | 양호 |
10일 | 양호 | 양호 | 양호 | 양호 | |
15일 | 양호 | 크리밍 | 크리밍 | 양호 | |
한달 | 양호 | 크리밍 | 크리밍 | 양호 | |
45℃ | 5일 | 양호 | 양호 | 양호 | 양호 |
10일 | 양호 | 크리밍 | 양호 | 양호 | |
15일 | 양호 | 크리밍 | 크리밍 | 양호 | |
한달 | 크리밍 | 오일분리 | 오일분리 | 양호 | |
순환 | 5일 | 양호 | 양호 | 양호 | 양호 |
10일 | 양호 | 양호 | 양호 | 양호 | |
15일 | 양호 | 크리밍 | 크리밍 | 양호 | |
한달 | 양호 | 크리밍 | 크리밍 | 양호 |
Claims (13)
- 오일 및 폴리에틸렌글리콜 에스테르계 유화제를 포함하는 유상 성분; 및 폴리올 또는 폴리올 유도체를 포함하는 수상 성분을 포함하는 수중유형(O/W) 나노 에멀젼 조성물.
- 제 1 항에 있어서,상기 나노 에멀젼은 0 내지 4000cps의 점도를 가지는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 나노 에멀젼의 평균 입자 크기는 10 내지 500nm인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 나노 에멀젼은 백색을 나타내는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 폴리에틸렌글리콜 에스테르계 유화제는 중합도 3 내지 90의 피이지-n 글리세릴 이소스테아레이트인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 폴리에틸렌글리콜 에스테르계 유화제는 조성물 총 중량을 기준으로 0.1 내지 10 중량%로 포함되는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 오일은 실리콘 오일, 에스테르계 오일, 하이드로카본계 오일 및 이들의 혼합물로 이루어진 군에서 선택된 하나 이상인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서,상기 오일은 트리에칠헥사노인, 디메치콘, 세틸옥타노에이트, 디카프릴레이트/디카프레이트, 이소프로필미리스테이트, 토코페놀아세테이트 및 카프릴릭/카프릭 트리글리세라이트로 이루어진 군에서 선택된 하나 이상인 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 오일은 조성물 총 중량을 기준으로 1 내지 20 중량%로 포함되는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서,상기 폴리올 또는 폴리올 유도체는 글리세린, 1가 또는 2가의 알코올 및 이들의 혼합물로 이루어진 군에서 선택된 하나 이상을 포함하는 것을 특징으로 하는 조성물.
- 제 1 항 내지 제 10 항 중 어느 하나의 나노 에멀젼 조성물을 포함하는 화장료 조성물.
- 오일 및 폴리에틸렌글리콜 에스테르계 유화제를 포함하는 유상 성분을 가열하는 단계;폴리올 또는 폴리올 유도체를 가열하는 단계;상기 유상 성분을 상기 폴리올 또는 폴리올 유도체에 투입하여 폴리올중유형(O/P) 겔을 형성하는 단계;상기 폴리올중유형 겔에 수상 성분을 첨가하여 교반하는 단계; 및상기 교반된 성분을 냉각하는 단계를 포함하는 수중유형 나노 에멀젼 조성물의 제조방법.
- 제 12 항에 있어서,상기 폴리에틸렌글리콜 에스테르계 유화제는 중합도 3 내지 90의 피이지-n 글리세릴 이소스테아레이트인 것을 특징으로 하는 수중유형 나노 에멀젼 조성물의 제조방법.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201180015623.0A CN102821756B (zh) | 2010-03-23 | 2011-03-22 | 水包油型纳米乳剂组合物及其制备方法 |
US13/635,784 US9132091B2 (en) | 2010-03-23 | 2011-03-22 | Oil-in-water type nano-emulsion composition and method for preparing same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020100025834A KR101163862B1 (ko) | 2010-03-23 | 2010-03-23 | 수중유형 나노 에멀젼 조성물 및 이의 제조방법 |
KR10-2010-0025834 | 2010-03-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011118958A2 true WO2011118958A2 (ko) | 2011-09-29 |
WO2011118958A3 WO2011118958A3 (ko) | 2012-01-12 |
Family
ID=44673949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/001953 WO2011118958A2 (ko) | 2010-03-23 | 2011-03-22 | 수중유형 나노 에멀젼 조성물 및 이의 제조방법 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9132091B2 (ko) |
KR (1) | KR101163862B1 (ko) |
CN (1) | CN102821756B (ko) |
WO (1) | WO2011118958A2 (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017085508A1 (en) | 2015-11-19 | 2017-05-26 | Sofia University "St. Kliment Ohridski" | A method for the preparation of particles with controlled shape and/or size |
WO2019213707A1 (en) * | 2018-05-11 | 2019-11-14 | Formulytica Pty Ltd | Sub-micron emulsions |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2875803A1 (en) * | 2013-11-26 | 2015-05-27 | OTC GmbH | Polyol-in-oil-emulsions for dermal delivery |
KR102120789B1 (ko) * | 2014-11-12 | 2020-06-09 | 주식회사 엘지생활건강 | 고함량의 오일을 안정화시킨 나노에멀전 화장료 조성물 |
JP6843153B2 (ja) * | 2016-04-08 | 2021-03-17 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 高含量のオイルを安定化したナノエマルジョン化粧料組成物 |
EP3507342A4 (en) * | 2016-11-21 | 2020-05-13 | Multi-Chem Group, LLC | NANO EMULSIONS FOR USE WITH UNDERGROUND FRACTURING TREATMENTS |
CN107412014A (zh) * | 2017-05-02 | 2017-12-01 | 上海应用技术大学 | 一种含有美藤果油的纳米体系导入液及其制备方法 |
KR102646643B1 (ko) | 2017-09-14 | 2024-03-12 | 신에쓰 가가꾸 고교 가부시끼가이샤 | 수중유형 유화 조성물의 제조 방법 및 화장료 |
FR3089416B1 (fr) * | 2018-12-05 | 2021-04-02 | Roquette Freres | Composition émulsionnante comprenant un émulsionnant eau-dans-huile et une cyclodextrine de granulométrie sélectionnée, apte à fournir une émulsion huile-dans-eau avec effets sensoriels améliorés, à usage cosmétique. |
CN113116780A (zh) * | 2021-04-20 | 2021-07-16 | 东晟源研究院(广州)有限公司 | 一款转相按摩膏的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001055308A (ja) * | 1999-06-21 | 2001-02-27 | L'oreal Sa | 有機ゲルとその化粧分野における使用 |
KR100540166B1 (ko) * | 2003-09-03 | 2005-12-29 | 주식회사 한생화장품 | 나노 에멀젼, 이의 제조 방법 및 이를 함유한 화장료 조성물 |
KR100623013B1 (ko) * | 2004-09-04 | 2006-09-19 | 김영대 | 나노에멀션, 그의 용도 및 제조방법 |
KR100654841B1 (ko) * | 2005-06-27 | 2006-12-06 | 한국콜마 주식회사 | 피부유사구조 및 조성을 갖고 생리활성물질의 경피흡수를촉진하는 지질 용해부 조성물 및 이를 이용한 나노입자화장료의 제조방법 |
KR100740598B1 (ko) * | 2006-02-08 | 2007-07-18 | 한국화장품주식회사 | 수중유형 에멀젼 화장료 조성물 |
KR20070083367A (ko) * | 2006-02-21 | 2007-08-24 | 주식회사 엘지생활건강 | 비수성 성분과 수중유 에멀젼을 포함하는 화장료 조성물 및이를 포함하는 화장품 |
US20070213234A1 (en) * | 2004-05-18 | 2007-09-13 | Nestec S.A. | Oil-in-water emulsion for delivery |
KR100874877B1 (ko) * | 2007-03-22 | 2008-12-19 | 한국콜마 주식회사 | 폴리올중유형 고밀집 나노 농축 에멀젼을 이용한유중수중유형 역상 다중 에멀젼 상의 화장료 조성물 및 그제조방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
US4478853A (en) * | 1982-05-17 | 1984-10-23 | S. C. Johnson & Son, Inc. | Skin conditioning composition |
US5744148A (en) * | 1996-09-20 | 1998-04-28 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Stabilization of an unstable retinoid in oil-in-water emulsions for skin care compositions |
FR2787712B1 (fr) * | 1998-12-24 | 2002-08-30 | Sanofi Sa | Composition cosmetique pulverisable et matrice utilisable dans cette composition pour une administration dermique |
US8741322B2 (en) * | 2004-06-28 | 2014-06-03 | L'oreal | Water oil-in-water emulsion |
TW200744663A (en) * | 2005-07-27 | 2007-12-16 | Showa Denko Kk | Emulsified skin external preparation and method for stabilizing the skin external preparation |
-
2010
- 2010-03-23 KR KR1020100025834A patent/KR101163862B1/ko active IP Right Grant
-
2011
- 2011-03-22 CN CN201180015623.0A patent/CN102821756B/zh active Active
- 2011-03-22 US US13/635,784 patent/US9132091B2/en active Active
- 2011-03-22 WO PCT/KR2011/001953 patent/WO2011118958A2/ko active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001055308A (ja) * | 1999-06-21 | 2001-02-27 | L'oreal Sa | 有機ゲルとその化粧分野における使用 |
KR100540166B1 (ko) * | 2003-09-03 | 2005-12-29 | 주식회사 한생화장품 | 나노 에멀젼, 이의 제조 방법 및 이를 함유한 화장료 조성물 |
US20070213234A1 (en) * | 2004-05-18 | 2007-09-13 | Nestec S.A. | Oil-in-water emulsion for delivery |
KR100623013B1 (ko) * | 2004-09-04 | 2006-09-19 | 김영대 | 나노에멀션, 그의 용도 및 제조방법 |
KR100654841B1 (ko) * | 2005-06-27 | 2006-12-06 | 한국콜마 주식회사 | 피부유사구조 및 조성을 갖고 생리활성물질의 경피흡수를촉진하는 지질 용해부 조성물 및 이를 이용한 나노입자화장료의 제조방법 |
KR100740598B1 (ko) * | 2006-02-08 | 2007-07-18 | 한국화장품주식회사 | 수중유형 에멀젼 화장료 조성물 |
KR20070083367A (ko) * | 2006-02-21 | 2007-08-24 | 주식회사 엘지생활건강 | 비수성 성분과 수중유 에멀젼을 포함하는 화장료 조성물 및이를 포함하는 화장품 |
KR100874877B1 (ko) * | 2007-03-22 | 2008-12-19 | 한국콜마 주식회사 | 폴리올중유형 고밀집 나노 농축 에멀젼을 이용한유중수중유형 역상 다중 에멀젼 상의 화장료 조성물 및 그제조방법 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017085508A1 (en) | 2015-11-19 | 2017-05-26 | Sofia University "St. Kliment Ohridski" | A method for the preparation of particles with controlled shape and/or size |
WO2019213707A1 (en) * | 2018-05-11 | 2019-11-14 | Formulytica Pty Ltd | Sub-micron emulsions |
Also Published As
Publication number | Publication date |
---|---|
WO2011118958A3 (ko) | 2012-01-12 |
KR20110106657A (ko) | 2011-09-29 |
CN102821756B (zh) | 2014-11-19 |
CN102821756A (zh) | 2012-12-12 |
US9132091B2 (en) | 2015-09-15 |
KR101163862B1 (ko) | 2012-07-09 |
US20130011454A1 (en) | 2013-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2011118958A2 (ko) | 수중유형 나노 에멀젼 조성물 및 이의 제조방법 | |
KR102237462B1 (ko) | 고함량의 오일을 안정화시킨 나노에멀전 화장료 조성물의 제조방법 | |
AU706178B2 (en) | Stable water-in-oil emulsion system | |
KR101472304B1 (ko) | 안정하고 균일한 입도분포를 가지는 나노에멀젼 | |
EP2644188B1 (en) | Oil-in-water-type emulsion skin cosmetic | |
WO2018056684A1 (ko) | 수중유형 화장료 조성물 | |
WO2017003130A1 (ko) | 다공성 다면체 파우더를 포함하는 유중수형 화장료 조성물 | |
US6346507B1 (en) | Liquid crystal composition and cosmetic preparation | |
KR101692163B1 (ko) | 실리콘 유도체와 다가 알코올이 다량 함유된 투명 w/s 화장품 유화물의 제조방법과 이를 포함하는 화장품 조성물 | |
WO2017191924A1 (ko) | 폴리글리세릴계 유화제를 포함하는 나노에멀젼 조성물 | |
EP0836847B1 (de) | Stabile Mehrphasenemulsion vom Typ O1/W/O2 | |
KR102337025B1 (ko) | 유화 입자의 크기 편차를 개선한 수중유형(o/w) 에멀젼 화장료 조성물 및 이의 제조 방법 | |
KR20120039863A (ko) | 나노에멀젼 유화제 및 이를 함유하는 화장료 조성물 | |
US20210220234A1 (en) | Nano-Emulsion Cosmetic Composition In Which High Content Oils Are Stabilized | |
WO2015137647A1 (ko) | 유화제를 함유하지 않는 유화 화장료 조성물 | |
WO2019045515A1 (ko) | 고함량 오일 내상을 안정화한 수중유형 화장료 조성물 | |
KR101038589B1 (ko) | 전상온도유화법을 이용하여 수중유형 에멀젼 제조 시 전상온도의 조절방법, 이를 통하여 제조한 o/w형 나노에멀젼 및 이를 함유하는 화장료 조성물 | |
DE19734544B4 (de) | Schellackhaltiges kosmetisches Produkt und Verfahren zu dessen Herstellung | |
WO2022145808A1 (ko) | 오일 겔화제를 포함하는 수중유형 화장료 조성물 및 이의 제조방법 | |
KR102337010B1 (ko) | 고함량 오일을 안정화시킨 반투명 수중유형(o/w) 화장료 조성물 및 이의 제조방법 | |
JP3440437B2 (ja) | O/w/o型乳化組成物 | |
KR100501728B1 (ko) | 나노사이즈의 화장료용 다중액정 막 캡슐 조성물과 그제조 방법 | |
WO2020145743A1 (ko) | 화장료용 에멀젼 조성물 및 이를 포함하는 화장료 조성물 | |
KR20160068177A (ko) | 미리스틸 3-글리세릴아스코베이트를 포함하는 나노 전달체 함유 화장료 조성물 | |
KR20200049150A (ko) | 고함량의 오일을 포함하는 저점도의 수중유형 화장료 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201180015623.0 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11759707 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13635784 Country of ref document: US |
|
NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 11759707 Country of ref document: EP Kind code of ref document: A2 |