WO2011115420A3 - Adhesive extracellular matrix mimetic - Google Patents

Adhesive extracellular matrix mimetic Download PDF

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Publication number
WO2011115420A3
WO2011115420A3 PCT/KR2011/001831 KR2011001831W WO2011115420A3 WO 2011115420 A3 WO2011115420 A3 WO 2011115420A3 KR 2011001831 W KR2011001831 W KR 2011001831W WO 2011115420 A3 WO2011115420 A3 WO 2011115420A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
extracellular matrix
vitro
vivo
adhesive
Prior art date
Application number
PCT/KR2011/001831
Other languages
French (fr)
Other versions
WO2011115420A2 (en
Inventor
Jaeyoon Kim
Taehoon G. Lee
Kilwon Cho
Hosun Lim
Seung Goo Lee
Original Assignee
Kollodis Biosciences, Inc.
Kollodis Korea, Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kollodis Biosciences, Inc., Kollodis Korea, Co., Ltd. filed Critical Kollodis Biosciences, Inc.
Publication of WO2011115420A2 publication Critical patent/WO2011115420A2/en
Publication of WO2011115420A3 publication Critical patent/WO2011115420A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An extracellular matrix mimetic comprising a hydrogel which is formed by crosslinking a recombinant mussel adhesive protein and a bio-polymer is provided. The three dimensional hydrogel matrix provides biochemical and biophysical microenvironments similar to native extracellular matrix and thus is capable of supporting cell in-growth in vivo or in vitro. The matrix can be tailored to further comprise one or more bioactive peptides. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating or differentiating upon deposition of the matrix in vivo or in vitro. Methods of preparing the adhesive extracellular matrix and the use of the matrix in vivo or in vitro for tissue engineering or drug delivery applications are also provided.
PCT/KR2011/001831 2010-03-16 2011-03-16 Adhesive extracellular matrix mimetic WO2011115420A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34033810P 2010-03-16 2010-03-16
US61/340,338 2010-03-16

Publications (2)

Publication Number Publication Date
WO2011115420A2 WO2011115420A2 (en) 2011-09-22
WO2011115420A3 true WO2011115420A3 (en) 2012-01-26

Family

ID=44649720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/001831 WO2011115420A2 (en) 2010-03-16 2011-03-16 Adhesive extracellular matrix mimetic

Country Status (1)

Country Link
WO (1) WO2011115420A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101311325B1 (en) * 2012-09-13 2013-09-30 이상재 Synthetically designed 3d microenvironment structure
JP5992529B2 (en) * 2012-09-26 2016-09-14 富士フイルム株式会社 Polypeptide, scaffold composition, cartilage tissue repair composition, chondrocyte culture composition and glycosaminoglycan production promoting composition
EP3080246A4 (en) * 2013-12-11 2017-05-24 The Regents of The University of California Compositions and methods for producing and administering brown adipocytes
CN104623725B (en) * 2014-12-31 2017-01-18 深圳清华大学研究院 Bioadhesive and preparation method thereof
KR101714695B1 (en) * 2015-05-18 2017-03-09 한국과학기술연구원 Method of producing cross-linked PVA-ECM composite and PVA-ECM composite produced thereby
KR20170017499A (en) * 2015-08-07 2017-02-15 콜로디스 바이오사이언스, 인코포레이티드 Biofunctional Adhesive Composition
US11578106B2 (en) 2015-08-07 2023-02-14 TME Therapeutics Co., Ltd. Surfactant adhesive composition
CN105457085B (en) * 2016-01-25 2018-03-02 华中农业大学 A kind of bionical adhesion hydrogel of collagen-based mussel and preparation method thereof
WO2018030569A1 (en) * 2016-08-12 2018-02-15 소망화장품주식회사 Makeup cosmetic composition containing mussel adhesive proteins
AU2016431869B2 (en) * 2016-12-07 2021-12-09 Amolifescience Co., Ltd. Three-dimensional micro-environment structure for controlling cell behavior, three-dimensional surface for controlling cell behavior, and method for manufacturing array and three-dimensional micro-environment structure
CN111727234A (en) * 2017-11-22 2020-09-29 新泽西州立罗格斯大学 Bioactive 3D encapsulated culture system for cell expansion
KR101870104B1 (en) * 2018-02-28 2018-06-21 주식회사 코스모코스 Hair cosmetic composition comprising mussel adhesive proteins
KR102222704B1 (en) * 2018-05-18 2021-03-04 포항공과대학교 산학협력단 Hydrogel formulation based microneedle adhesive patch
CN109568649A (en) * 2018-11-27 2019-04-05 普丽妍（南京）医疗科技有限公司 A kind of anti-bacterial, anti-itching temperature-sensitivcomposite composite hydrogel and preparation method thereof
CN109646723B (en) * 2019-02-02 2020-05-22 上海瑞凝生物科技有限公司 Medical hydrogel with radiation protection effect
CN110790885B (en) * 2019-08-30 2022-05-03 武汉理工大学 Polyvinyl alcohol/chitosan quaternary ammonium salt antibacterial self-healing hydrogel and preparation method and application thereof
US11643574B2 (en) 2021-05-28 2023-05-09 Cohesys Inc. Adhesive devices and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040208845A1 (en) * 2003-04-15 2004-10-21 Michal Eugene T. Methods and compositions to treat myocardial conditions
EP1493404A1 (en) * 2003-06-30 2005-01-05 DePuy Mitek, Inc. Scaffold for connective tissue repair

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040208845A1 (en) * 2003-04-15 2004-10-21 Michal Eugene T. Methods and compositions to treat myocardial conditions
EP1493404A1 (en) * 2003-06-30 2005-01-05 DePuy Mitek, Inc. Scaffold for connective tissue repair

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CANDAN TAMERLER ET AL., ACNANO, vol. 3, no. 7, 2009, pages 1606 - 1615 *
KAZUHIRO NAKANISHI ET AL., J. OF BIOSCIENCE AND BIOENGINEERING, vol. 91, no. 3, 2001, pages 233 - 244 *
KUEN YONG LEE ET AL., CHEMICAL REVIEWS, vol. 101, no. 7, 2001, pages 1869 - 1879 *
LORENZO MORONI ET AL., MATERIALSTODAY, vol. 11, no. 5, 2008, pages 44 - 51 *
YOSHINORI ONUKI ET AL., JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, vol. 2, no. 6, 2008, pages 1003 - 1015 *

Also Published As

Publication number Publication date
WO2011115420A2 (en) 2011-09-22

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