WO2011105527A1 - Promoteur de croissance nerveuse - Google Patents

Promoteur de croissance nerveuse Download PDF

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Publication number
WO2011105527A1
WO2011105527A1 PCT/JP2011/054234 JP2011054234W WO2011105527A1 WO 2011105527 A1 WO2011105527 A1 WO 2011105527A1 JP 2011054234 W JP2011054234 W JP 2011054234W WO 2011105527 A1 WO2011105527 A1 WO 2011105527A1
Authority
WO
WIPO (PCT)
Prior art keywords
shp
antibody
pir
trk receptor
substance
Prior art date
Application number
PCT/JP2011/054234
Other languages
English (en)
Japanese (ja)
Inventor
俊英 山下
幸 藤田
Original Assignee
国立大学法人大阪大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国立大学法人大阪大学 filed Critical 国立大学法人大阪大学
Publication of WO2011105527A1 publication Critical patent/WO2011105527A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La présente invention concerne : (A) une substance inhibant la liaison entre SHP-1 ou SHP-2 et un récepteur Trk ; (B) une substance inhibant l'activité récepteur Trk tyrosine phosphatase de SHP-1 ou SHP-2 ; et (C) une substance inhibant l'expression de SHP-1 or SHP-2. Chacune des substances (A)-(C) décrites ci-avant peut être employée en tant que principe actif d'un promoteur de croissance nerveuse. La présente invention concerne également un promoteur de croissance nerveuse contenant l'une des substances (A)-(C) décrites ci-avant au titre de principe actif et employé comme produit pharmaceutique dans le soulagement des séquelles de troubles du système nerveux central comme les troubles vasculaires cérébraux, les lésions cérébrales traumatiques et les lésions de la moelle épinière.
PCT/JP2011/054234 2010-02-26 2011-02-25 Promoteur de croissance nerveuse WO2011105527A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010041180 2010-02-26
JP2010-041180 2010-02-26

Publications (1)

Publication Number Publication Date
WO2011105527A1 true WO2011105527A1 (fr) 2011-09-01

Family

ID=44506925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2011/054234 WO2011105527A1 (fr) 2010-02-26 2011-02-25 Promoteur de croissance nerveuse

Country Status (1)

Country Link
WO (1) WO2011105527A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014532637A (ja) * 2011-11-01 2014-12-08 ピーエイチ セラピューティクス リミテッド 肺高血圧症

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010043026A (ja) * 2008-08-13 2010-02-25 Japan Health Science Foundation チロシン脱リン酸化酵素のペプチド基質およびチロシン脱リン酸化酵素の阻害作用を有するペプチド

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010043026A (ja) * 2008-08-13 2010-02-25 Japan Health Science Foundation チロシン脱リン酸化酵素のペプチド基質およびチロシン脱リン酸化酵素の阻害作用を有するペプチド

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JAPAN SCIENCE AND TECHNOLOGY AGENCY: "Kizutsuita Shishinkei no Saisei o Yokusei suru Mechanism o Kaimei (Mouse no Jikken de Shishinkei Saisei ni Seiko)", PRESS RELEASE 2010 NENDO, 2 March 2011 (2011-03-02), OSAKA UNIVERSITY, Retrieved from the Internet <URL:http://www.jst.go.jp/pr/announce/20110302/index.html> [retrieved on 20110523] *
MARSH, H.N. ET AL.: "SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase", J. CELL BIOL., vol. 163, no. 5, 8 December 2003 (2003-12-08), pages 999 - 1010 *
ROSARIO, M. ET AL.: "The neurite outgrowth multiadaptor RhoGAP, NoMA-GAP, regulates neurite extension through SHP2 and Cdc42", J. CELL BIOL., vol. 178, no. 3, 30 July 2007 (2007-07-30), pages 503 - 516 *
WANG, N. ET AL.: "Antagonism or synergism: Role of tyrosine phosphatase SHP-1 and SHP-2 in growth factor signaling", J. BIOL. CHEM., vol. 281, no. 31, 4 August 2006 (2006-08-04), pages 21878 - 21883 *
YOKO AOKI: "Shinkei Kan Saibo ni Okeru Tyrosine Phosphatase SHP-2 no Yakuwari", IGAKU NO AYUMI, vol. 201, no. 5, 4 May 2002 (2002-05-04), pages 319 - 324 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014532637A (ja) * 2011-11-01 2014-12-08 ピーエイチ セラピューティクス リミテッド 肺高血圧症

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