WO2011090297A3 - 항－ｍｄｍ２를 발현하는 인간 성체줄기세포 및 그의 용도 - Google Patents

항－ｍｄｍ２를 발현하는 인간 성체줄기세포 및 그의 용도 Download PDF

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WO2011090297A3
WO2011090297A3 PCT/KR2011/000329 KR2011000329W WO2011090297A3 WO 2011090297 A3 WO2011090297 A3 WO 2011090297A3 KR 2011000329 W KR2011000329 W KR 2011000329W WO 2011090297 A3 WO2011090297 A3 WO 2011090297A3
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mdm2
stem cell
adult stem
human adult
expressing anti
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WO2011090297A2 (ko
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박국인
김일선
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연세대학교 산학협력단
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Publication of WO2011090297A2 publication Critical patent/WO2011090297A2/ko
Publication of WO2011090297A3 publication Critical patent/WO2011090297A3/ko

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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
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  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 항-MDM2를 암호화하는 핵산을 포함하는 인간의 신경줄기세포 및 이를 포함한 암 치료용 약제학적 조성물을 제공한다. 본 발명의 항-MDM2를 암호화하는 핵산을 포함하는 인간의 신경줄기세포는 세포독성을 유발하지 않으면서, 생체 내에서 항-MDM2를 분비하여 비정상 세포의 아폽토시스를 유발하므로 암 등 세포과다증식 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
PCT/KR2011/000329 2010-01-21 2011-01-17 항－ｍｄｍ２를 발현하는 인간 성체줄기세포 및 그의 용도 WO2011090297A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0005723 2010-01-21
KR1020100005723A KR101220516B1 (ko) 2010-01-21 2010-01-21 항－ｍｄｍ２를 발현하는 인간 성체줄기세포 및 그의 용도

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WO2011090297A2 WO2011090297A2 (ko) 2011-07-28
WO2011090297A3 true WO2011090297A3 (ko) 2011-12-29

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PCT/KR2011/000329 WO2011090297A2 (ko) 2010-01-21 2011-01-17 항－ｍｄｍ２를 발현하는 인간 성체줄기세포 및 그의 용도

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KR (1) KR101220516B1 (ko)
WO (1) WO2011090297A2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008095063A1 (en) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2017003819A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y formulaciones de los mismos.
CN107614003A (zh) 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002642A1 (en) * 1994-07-20 1996-02-01 University Of Dundee INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002642A1 (en) * 1994-07-20 1996-02-01 University Of Dundee INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHENE ET AL.: "Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface", MOLECULAR CANCER RESEARCH, vol. 2, 2004, pages 20 - 28 *
MENG ET AL.: "Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis Type VII Mouse", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 74, 2003, pages 266 - 277, XP002997245 *

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WO2011090297A2 (ko) 2011-07-28
KR20110085765A (ko) 2011-07-27
KR101220516B1 (ko) 2013-01-10

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