WO2011086529A1 - Corps d'implant en treillis tridimensionnel - Google Patents

Corps d'implant en treillis tridimensionnel Download PDF

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Publication number
WO2011086529A1
WO2011086529A1 PCT/IB2011/050184 IB2011050184W WO2011086529A1 WO 2011086529 A1 WO2011086529 A1 WO 2011086529A1 IB 2011050184 W IB2011050184 W IB 2011050184W WO 2011086529 A1 WO2011086529 A1 WO 2011086529A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
dental implant
dimensional lattice
implants
dental
Prior art date
Application number
PCT/IB2011/050184
Other languages
English (en)
Inventor
Eliezer Bar Shalom
Original Assignee
A.B. Dental Devices Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A.B. Dental Devices Ltd. filed Critical A.B. Dental Devices Ltd.
Publication of WO2011086529A1 publication Critical patent/WO2011086529A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0006—Production methods
    • A61C13/0013—Production methods using stereolithographic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0006—Production methods
    • A61C13/0018—Production methods using laser
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing

Definitions

  • the present invention relates to the field of dentistry, and more particularly, to dental implants.
  • Dental implants are implanted in the patients jaw in order to allow attachment of prostheses. Anchoring the dental implant in the jaw poses difficulties of bone abrasion and implant de-stabilization as the implant stays an alien part in the jaw.
  • the following patents and patent applications disclose various dental implants and implantation appliances with pores or tunnels.
  • European Patent Document No. 1133957 discloses implants with channels that promote bone ingrowth, European
  • Patent Document No. EP1764061 discloses producing dental implants with surface cavities by laser sintering
  • U.S. Patent Publication No. 20030224328 discloses a biofunctional dental implant system for affixing a crown to an implant socket, that enables the crown to have a selectively controllable mobility relative to the root portion that is anchored within the implant socket
  • Spanish Patent Document No. 2288437 discloses an implant having conduits for introducing substances into the surroundings of the implant
  • European Patent Document No. 1430843 discloses an apparatus for embedding an implant in bone tissue in a way that encourages bone tissue growth
  • WIPO Publication No. 2006096720 discloses an implantable dental screw
  • 03073912 discloses implants constructed of a biodegradable polymer formed into a structure having micro-architectural features for in-situ application of a liquid biodegradable polymer
  • European Patent Document No. 1093766 discloses implants with numerous microscopic dents which increase the surface area
  • European Patent Document No. 1991169 discloses laser treating the surface of implantable devices.
  • Embodiments of the present invention provide a dental implant having a body comprising an inner thread for connecting an abutment thereto and an outer thread for connecting the dental implant to a jaw bone, characterized in that the body is at least partially porous.
  • the porosity structure is arranged to enhance bone growth into the body, and the dental implant is produced layer by layer by laser sintering, wherein the bone growth into the body enhances implant stability and allows for close implantation of neighbouring implants.
  • FIGS. 1A-1D are high level schematic illustrations of a dental implant, according to some embodiments of the invention.
  • FIGS. 2A and 2B are high level schematic illustrations of a dental implant, according to some embodiments of the invention.
  • Figure 3 is a high level flowchart illustrating a method of dental implants' production, according to some embodiments of the invention.
  • Figure 4 shows a dental implant having "through channels", according to some embodiments of the invention.
  • Figure 5 shows the dental implant shown in Figure 4 in partial cross section, according to some embodiments of the invention.
  • Figure 6 shows a cross-sectional portion of the dental implant shown in Figure 4, according to some embodiments of the invention.
  • Figure 7 shows a schematic drawing of a manufacturing device configured for producing a dental implant according to some embodiments of the invention.
  • three dimensional lattice as used herein in this application, is defined as a three dimensional network of material comprising spaces of various dimensions (e.g. tunnels) that penetrate the whole volume.
  • the density of the three dimensional lattice may be uniform or variable.
  • the spaces may be of constant or variable cross sectional form and area.
  • the three dimensional lattice may comprise multiple adjacent two dimensional meshes such that the spaces are interconnected and characterized by the mesh opening parameters.
  • Figures 1A-1D are high level schematic illustrations of a dental implant 100, according to some embodiments of the invention.
  • Figure 1A is a perspective view
  • Figure IB is a side view
  • Figure 1C is a cross sectional view
  • Figure ID presents a detail marked 97 in Figure 1C which illustrates in magnification the structure of the three dimensional lattice, according to some embodiments of the invention.
  • the three dimensional lattice is represented in Figures 1A-1C in a schematic manner.
  • Dental implant 100 has a body 110 comprising an inner thread 90 for connecting an abutment (not shown) thereto and an outer thread 95 for connecting dental implant 100 to a jaw bone (not shown).
  • Inner thread 90 may extend to varying depths within body 110, according to the size of implant 100 and its type of connection with the abutment. Inner thread 90 may be supported by a layer 120 of solid material, to ensure the stability of the connection to the abutment. Outer thread 95 may also be supported by a solid layer (not shown). Supporting layers (e.g. layer 120) may be either solid or have a higher density than other parts of body 110.
  • Body 110 is at least partially porous, e.g. comprising a three dimensional lattice (hatched in Figures 1A-1C) arranged to enhance bone growth into body 110.
  • the porosity of body 110 is arranged to create many free trajectories through implant 110 for the bone to grow into and to occupy, resulting in a good integration of implant 110 in the jaw.
  • Figure ID illustrates a possible structure of the porous core as a three dimensional lattice - interwoven or parallel layers of a two dimensional mesh, optionally with openings of different forms and sizes 115A, 115B. Openings 115A may be larger than openings 115B according to their position in implant 100 and to implantation considerations in case of tailored implants 100.
  • FIG. 2A is high level schematic illustration of dental implant 100, according to some embodiments of the invention.
  • Body 110 may comprise a solid part 110A and a porous part HOB.
  • Figure 2B illustrates a pattern 111 of one type of porosity that may be implemented - square openings 115C arranged in rows that are shifted from each other. Pattern 111 may be applied to both a side view and a view from the bottom of dental implant 100, or may be applied on other two surfaces to build the three dimensional lattice with specified characteristics.
  • Dental implant 100 is produced layer by layer by laser sintering.
  • the bone growth into body 110 enhances the stability of dental implant 100 and allows for close implantation of neighbouring implants.
  • Layer wise laser sintering allow generating continuous changes in the density of the three dimensional lattice through body 110 and in the transition to outer thread 95 and to inner thread 90.
  • the border illustrated in Figure ID between body 110 and outer thread 95 is for illustrative purposes, and may be replaced by continuous changes without any clear-cut border.
  • the three dimensional lattice may have an opening diameter between 0.1 and 1 millimeter, that may be selected according to implant size, intended use and surrounding tissue. Opening size may vary among different regions of body 100, in relation to expected surrounding tissue (bone type, gum) and its characteristic growth, in relation to the expected location of implant 100 in the jaw, and in respect to structural considerations or implant planning and the need to assure sufficient mechanical support to the inner and outer threads 90, 95.
  • Opening size may vary continuously within body 110, according to the afore mentioned criteria.
  • Implant density may vary together with opening size to yield implants 100 with a continuously variable density.
  • lattice openings may be chosen according to functional or structural criteria.
  • Lattice openings may be round, square, hexagonal, or variable within body 110.
  • the distances between adjacent openings may be between 0.2 and 1.5 millimeter and may also vary within implant 100 according to implant size and intended use. Changing distances between adjacent openings may be associated with the density variation of implant 100.
  • Dental implant 100 may be produced layer-wise by laser sintering. This production methods allows to tailor implants 100 according to implantation requirements (size, form and density distribution), as well as to mass produced specifically planned implant. The layer- wise production allows exact planning of lattice opening sizes and separation according to optimized models, adapted to bone growth parameters.
  • Layer- wise by laser sintering allows generating a very fine and a three dimensionally complex implant structure, which is difficult to achieve in other methods.
  • implant 100 with three dimensional lattice body 110 by laser sintering is sparing implant material, as hollows in implant 100 are not cut out.
  • Bone growth factors may be associated with the produced implants 100 (e.g. implants may be soaked with bone growth factor prior to implantation) to enhance bone growth.
  • the sizes and connectivity of lattice inner spaces may be selected to admit predefined amounts of specified solutions (e.g. bone growth factors, disinfectors, antibiotics, etc.).
  • the three dimensional lattice may have interconnected inner spaces, isolated inner spaces or a mix of the two, according to functional requirements from implant 100.
  • Implant size may vary between 0.6 to 2 millimeter in length. Different overall implant lengths and widths may determine the extent of body 110 and of the three dimensional lattice throughout body 110.
  • Figure 3 is a high level flowchart illustrating a method 150 of dental implants' production, according to some embodiments of the invention.
  • Method 150 comprises defining at least one three dimensional structure (e.g. a lattice) of a dental implant, to yield enhanced bone growth into the dental implant upon implantation (stage 155); and producing, simultaneously, by layer-wise laser sintering, a plurality of dental implants according to the at least one three dimensional structure (stage 160), wherein the enhanced bone growth into the body enhances implant stability and allows for close implantation of neighbouring implants.
  • at least one three dimensional structure e.g. a lattice
  • the at least one three dimensional lattice structure may comprise a plurality of three dimensional lattice structures, each defined according to specified implantation requirements.
  • Method 150 allow producing any number of any specially designed dental implant.
  • stage 160 may comprise producing many implants of a single defined three dimensional lattice structures (stage 162), producing simultaneously different dental implants with individually tailored three dimensional lattice structures (stage 164) or a combination thereof.
  • Method 150 may further comprise deriving body structural parameters of dental implants according to implantation conditions (stage 152) and defining and producing the implants (stages 155, 160) accordingly.
  • stage 152 body structural parameters of dental implants according to implantation conditions
  • stage 155, 160 the implants
  • the described implant 100 and method 200 allow generating a "bone implant” within the jaw, which both stabilizes implant 100, by reducing rejection and improper healing around implant 100, and allows placing multiple implants in closer proximity to each other, to better support the prostheses.
  • Figures 4-6 illustrate dental implant 100 having "through channels", according to some embodiments of the invention.
  • Figure 4 is a perspective view
  • Figure 5 is a partial cross section
  • Figure 6 is a cross-sectional view.
  • Dental implant 100 has a body 110 comprising an inner thread 90 for connecting an abutment (not shown) thereto and an outer thread 95 for connecting dental implant 100 to a jaw bone (not shown).
  • Inner thread 90 may be supported by a layer 120 of solid material, to ensure the stability of the connection to the abutment.
  • Outer thread 95 may also be supported by a solid layer (not shown).
  • Supporting layers e.g. layer 120
  • FIGS 4 and 5 show a dental implant 100 having channels 122 therethrough.
  • Dental implant 100 additionally includes threads 95 and a prosthetic head 116.
  • Prosthetic head 116 includes an abutment receptacle 114 configured for supporting an abutment (not shown).
  • Abutment receptacle 114 optionally comprises an octagonal cross-sectional shape which receives an abutment having an octagonal shape.
  • the cross-sectional shape of abutment receptacle 114 is triangular, square configured for receiving projections of similar shapes from the corresponding abutments.
  • the cross-sectional shape of abutment receptacle 114 is a five or six point star design.
  • receptacle 114 comprises a cylinder having a round cross sectional cross section, and the walls of the cylinder are optionally threaded to receive a threaded screw.
  • receptacle 114 comprises a peg that extends above dental implant 100 and is configured to pass into an appropriately shaped receptacle in an abutment and/or prosthetic.
  • the many options for connecting dental implant 100 to abutments and/or prosthetics are well known to those familiar with the industry.
  • channels 122 pass through the thickness of implant 100 into a core 118 which is hollow.
  • Channels 122 are optionally cylindrical and have a round cross- section to those familiar with the industry n shape.
  • abutment receptacle 114 includes channels 122.
  • channels 122 have a polygon cross-sectional shape.
  • the many options for creating cylindrical channels 122 are well known to those familiar with the industry.
  • Channels 122 optionally form a lattice structure as seen in Figure 5.
  • the configuration of the lattice structure may be as a ladder configuration however the lattice structure of channels 122 may include angled channels 122 for example that 45° to the vertical channels shown.
  • the many forms that channels 122 can form to create optimal infusion of bone 130 can be easily understood to those familiar with the industry.
  • Core 118 optionally includes an octagonal cross-sectional shape which is optionally contiguous with abutment receptacle 114.
  • the cross- sectional shape of core 118 is triangular, square, or hexagonal.
  • the cross-sectional shape of core 118 is a five or six point star design.
  • distance between multiple dental implants 100 may possibly be reduced from a standard amount of approximately 2 millimeters to about 1 millimeter.
  • channels 122 have a cross-sectional square area of between 70 and 800 microns and a depth of between about 10 and 100 microns.
  • channels 122 have a square area of between about 70 and 800 microns.
  • FIG. 7 shows a schematic drawing of a manufacturing device configured for producing a dental implant according to some embodiments of the invention.
  • implant 100 is produced in a production unit 11 including an atmosphere-controlled chamber 12 in which implant 100 is formed.
  • Layers of a powder 18 are optionally deposited with a thickness of between about 1 and 100 microns on a vertical platform 14 along a cylinder 19 utilizing a dispenser 111 that optimally moves across vertical platform 14.
  • a striker arm 13 of a laser generates a laser beam 140 that is directed by a reflector 142 towards the layer of powder 18 which was just deposited.
  • Powder 18 struck by laser beam 140 melts and solidifies to form an implant portion
  • platform 14 is moved downward as implant 100, consisting of one or more implant portions 16, is formed.
  • Controller 15 typically includes a computer processing unit (CPU) 146 that includes a software module 144 that provides digital three dimensional instructions that control movement of, inter alia, laser beam 140, reflector 142 and downward motion 148.
  • CPU computer processing unit
  • software module 144 provides digital three dimensional instructions that control movement of, inter alia, laser beam 140 and reflector 142.
  • reserve powder 17 around implant 100 can be recovered for a subsequent manufacturing process.
  • Layers of powder 18 optionally have a thickness of between about 1 and 100 microns.
  • Powder 18 optionally comprises medical grade 2 or 4 titanium powder or ceramic titanium powder.
  • the grains within each layer of powder 18 optionally are between about 10 and 200 nanometers in dimension.
  • the thickness of the layers of powder 18 as well as the grains within the layer may vary according to a variety of factors including improvements in existing art.
  • layers of powder 18 are sintered by laser beam 140 so that implant 100 acquires a generally cylindrical form.
  • chamber 12 is filled with an inert gas 149, for example argon, at a controlled atmospheric pressure so as to reduce potential impurities in implant 100.
  • an inert gas 149 for example argon
  • implant 100 is optionally introduced into a bath of distilled water or organic acids, and subjected to ultrasound treatment.
  • the device illustrated in Figure 7 may be similarly used to produce dental implant 100 illustrated in Figures 1A-1D and particularly its porous part of implant body 110.
  • dental implant 100 becomes affixed in place by the ingrowth of bone 130 into channels 122.
  • implant 100 provides greater long- term stability than the implant taught in EP 1764061 Al (Mangano, Carlo) which only includes pores on the surface of the implant.
  • the porous core structure and the three dimensional lattice core are arranged to accommodate bone ingrowth, and may be further individually designed and mass produced utilizing the layer-wise laser sintering method.
  • the porous core may be designed to have a complex structure without increasing the production complexity, in sharp contrast to most prior art.

Abstract

L'invention divulgue un implant dentaire comprenant un corps constitué d'un noyau poreux, comprenant par exemple un treillis tridimensionnel, qui est conçu pour améliorer la croissance osseuse dans le corps, qui est produit couche par couche par frittage au laser. La croissance osseuse dans le corps renforce la stabilité de l'implant et permet une proximité de la pose d'implants voisins. Le noyau poreux peut comprendre un treillis tridimensionnel qui présente une densité variant spatialement et qui peut changer de façon continue pour former les filets intérieurs et extérieurs de l'implant. La densité, qui est affectée par la taille, la forme et l'espacement des ouvertures, peut varier sur la base de considérations structurelles, et peut être créée sur mesure ou produite dans la masse.
PCT/IB2011/050184 2010-01-18 2011-01-16 Corps d'implant en treillis tridimensionnel WO2011086529A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1000674.0 2010-01-18
GB1000674A GB2476969A (en) 2010-01-18 2010-01-18 Dental implant comprising a plurality of channels
GB1017709.5 2010-10-20
GB1017709A GB2477010A (en) 2010-01-18 2010-10-20 Dental implant with pores

Publications (1)

Publication Number Publication Date
WO2011086529A1 true WO2011086529A1 (fr) 2011-07-21

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Country Status (2)

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GB (2) GB2476969A (fr)
WO (1) WO2011086529A1 (fr)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN103445883A (zh) * 2012-06-04 2013-12-18 合硕生技股份有限公司 镂空网架医疗用植入物
US10993754B2 (en) 2017-05-12 2021-05-04 Cutting Edge Spine Llc Implants for tissue fixation and fusion

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DE102016216718B4 (de) 2016-09-05 2023-07-27 Rolf Ebert Teleskopsystem und Verfahren zu dessen Herstellung
EP3417828B1 (fr) 2017-06-20 2021-03-03 Ruetschi Technology AG Procédé de fabrication d'un implant avec un matériau d'impression tridimensionnelle à base de titane
NL2019482B1 (en) * 2017-09-05 2019-03-14 Am Solutions Holding B V Dental implant, method of manufacturing a dental implant and method of placing a dental implant
EP3701906A1 (fr) * 2017-10-26 2020-09-02 Universidade do Minho Implant dentaire en zircone ou alumine à fonctions électriques thérapeutiques et procédé d'obtention correspondant
US20200281693A1 (en) * 2017-10-26 2020-09-10 Universidade Do Minho Dental implant with electrostimulation system and its production method

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GB1000674A (en) 1963-08-24 1965-08-11 Spembly Ltd Protective clothing
GB1017709A (en) 1964-05-27 1966-01-19 Galat Alexander Stable water soluble acetylsalicylic acid derivative and process for preparing the same
EP1430843A2 (fr) 1996-08-26 2004-06-23 Shedrick D. Jones Appareil-perceur pour l'encastrement d'un implant en tissu osseux
EP1133957A1 (fr) 1998-09-15 2001-09-19 Hiswill Research & Development Implants avec surface d'ancrage osseux et procédé associé
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EP1358855A1 (fr) * 2002-05-03 2003-11-05 BEGO medical AG Procédé pour la production d'objets par formage de formes libres lors d'un procédé de frittage au laser
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WO2005080029A1 (fr) * 2004-02-25 2005-09-01 Bego Medical Gmbh Procede et dispositif pour generer des enregistrements de commande pour produire des articles par frittage ou coulee sans matrice, ainsi que dispositif pour cette production
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EP1764061A1 (fr) 2005-09-16 2007-03-21 Leader Italia S.r.l. Méthode de fabrication d'une implantation dentaire intraosseuse avec une surface ayant une géométrie prédéfinie
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EP1991169A1 (fr) 2006-02-08 2008-11-19 R.T.M. S.p.A. Procede pour le traitement au laser de dispositifs implantables, dispositifs implantables obtenus en utilisant ledit procede et systeme laser pour le traitement de dispositifs implantables
ES2288437A1 (es) 2007-04-27 2008-01-01 Antonio Juan Flichy Fernandez Sistema de implante dental.
EP2158871A2 (fr) * 2008-08-29 2010-03-03 TuTech Innovation GmbH Implant médical et son procédé de fabrication
WO2010146383A1 (fr) * 2009-06-17 2010-12-23 Ulive Enterprises Limited Implant dentaire

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103445883A (zh) * 2012-06-04 2013-12-18 合硕生技股份有限公司 镂空网架医疗用植入物
US10993754B2 (en) 2017-05-12 2021-05-04 Cutting Edge Spine Llc Implants for tissue fixation and fusion
US11446070B2 (en) 2017-05-12 2022-09-20 Cutting Edge Spine Llc Implants for tissue fixation and fusion
US11771482B2 (en) 2017-05-12 2023-10-03 Cutting Edge Spine Llc Implants for tissue fixation and fusion

Also Published As

Publication number Publication date
GB2477010A (en) 2011-07-20
GB201017709D0 (en) 2010-12-01
GB201000674D0 (en) 2010-03-03
GB2476969A (en) 2011-07-20

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