WO2011081343A3 - ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법 - Google Patents

ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법 Download PDF

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WO2011081343A3
WO2011081343A3 PCT/KR2010/009172 KR2010009172W WO2011081343A3 WO 2011081343 A3 WO2011081343 A3 WO 2011081343A3 KR 2010009172 W KR2010009172 W KR 2010009172W WO 2011081343 A3 WO2011081343 A3 WO 2011081343A3
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genes
transgenic pig
tnfr1
simultaneously expressed
producing same
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PCT/KR2010/009172
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English (en)
French (fr)
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WO2011081343A2 (ko
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안규리
이병천
황종익
양재석
장구
조범래
구옥재
강정택
권대기
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한화엘앤씨 주식회사
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Priority to US13/520,056 priority Critical patent/US9018439B2/en
Priority to EP10841175.2A priority patent/EP2520164B1/en
Publication of WO2011081343A2 publication Critical patent/WO2011081343A2/ko
Publication of WO2011081343A3 publication Critical patent/WO2011081343A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
    • A01K2217/056—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to mutation of coding region of the transgene (dominant negative)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 인간 HO-1 유전자 및 TNFR1-Fc 융합 유전자를 동시에 발현하는 면역거부 반응이 억제된 형질전환 돼지의 제조 방법, 상기 방법에 의해 제조된 면역거부 반응이 억제된 장기 이식용 형질전환 돼지, 상기 형질전환 돼지를 제조하기 위한 체세포 공여 세포주 및 상기 형질전환 돼지로부터 면역거부 반응이 억제된 장기를 제조하는 방법에 관한 것이다.
PCT/KR2010/009172 2009-12-30 2010-12-21 ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법 WO2011081343A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/520,056 US9018439B2 (en) 2009-12-30 2010-12-21 Transgenic pig in which HO-1 and TNFR1-Fc are simultaneously expressed, and method for producing same
EP10841175.2A EP2520164B1 (en) 2009-12-30 2010-12-21 Transgenic pig in which ho-1 genes and tnfr1-fc genes are simultaneously expressed, and method for producing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20090134548 2009-12-30
KR10-2009-0134548 2009-12-30
KR10-2010-0090543 2010-09-15
KR1020100090543A KR101312829B1 (ko) 2009-12-30 2010-09-15 ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법

Publications (2)

Publication Number Publication Date
WO2011081343A2 WO2011081343A2 (ko) 2011-07-07
WO2011081343A3 true WO2011081343A3 (ko) 2011-11-17

Family

ID=44918852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/009172 WO2011081343A2 (ko) 2009-12-30 2010-12-21 ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법

Country Status (4)

Country Link
US (1) US9018439B2 (ko)
EP (1) EP2520164B1 (ko)
KR (1) KR101312829B1 (ko)
WO (1) WO2011081343A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101276801B1 (ko) * 2011-01-21 2013-06-19 한화엘앤씨 주식회사 ｓＴＮＦＲ1-Ｆｃ 유전자를 발현하는 형질전환 돼지 및 이의 용도
CN103463626B (zh) * 2013-03-03 2016-05-04 西北农林科技大学 Ho-1和ho-1的诱导剂作为抑制prrs病毒感染的新型阻断剂
KR101566498B1 (ko) 2013-11-13 2015-11-06 건국대학교 산학협력단 인터루킨 2 수용체 감마 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용
KR102613900B1 (ko) 2015-11-13 2023-12-15 서울대학교 산학협력단 HO-1 유전자 및 TNFR1-Fc 유전자를 동시에 발현하며 GGTA1 유전자가 넉아웃된 형질전환 돼지 및 이의 용도
KR102363891B1 (ko) * 2017-04-28 2022-02-17 서울대학교산학협력단 ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하며 GGTA1 유전자 및 CMAH 유전자가 넉아웃된 형질전환 돼지 및 이의 용도

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US20040028658A1 (en) * 2002-06-27 2004-02-12 Denise Faustman Methods of organ regeneration
US20050268347A1 (en) * 2004-06-01 2005-12-01 Animal Technology Institute Taiwan Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
KR20070081531A (ko) * 2006-02-13 2007-08-17 조아제약주식회사 유선 특이적 인간 에리트로포이에틴 발현 벡터, 이를이용한 형질전환 동물 및 이를 이용한 인간에리트로포이에틴의 생산 방법

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US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
AU2006292827B2 (en) * 2005-08-09 2013-02-14 Revivicor, Inc. Transgenic ungulates expressing CTLA4-IG and uses thereof

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Publication number Priority date Publication date Assignee Title
US20040028658A1 (en) * 2002-06-27 2004-02-12 Denise Faustman Methods of organ regeneration
US20050268347A1 (en) * 2004-06-01 2005-12-01 Animal Technology Institute Taiwan Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
KR20070081531A (ko) * 2006-02-13 2007-08-17 조아제약주식회사 유선 특이적 인간 에리트로포이에틴 발현 벡터, 이를이용한 형질전환 동물 및 이를 이용한 인간에리트로포이에틴의 생산 방법

Non-Patent Citations (3)

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Title
LAUMONIER, T. ET AL.: "Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig", MOLECULAR THERAPY, vol. 16, no. 2, February 2008 (2008-02-01), pages 404 - 410, XP008159717 *
LEE, G.-S ET AL.: "Production of transgenic cloned piglets from genetically transformed fetal fibroblasts selected by green fluorescent protein", THERIOGENOLOGY, vol. 63, 1 March 2005 (2005-03-01), pages 973 - 991, XP027746897 *
MACHEN, J. ET AL.: "Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy", GENE THERAPY, vol. 11, 1 July 2004 (2004-07-01), pages 1506 - 1514, XP008161595 *

Also Published As

Publication number Publication date
US20120278910A1 (en) 2012-11-01
KR101312829B1 (ko) 2013-09-27
KR20110079485A (ko) 2011-07-07
WO2011081343A2 (ko) 2011-07-07
EP2520164A2 (en) 2012-11-07
EP2520164B1 (en) 2018-10-03
EP2520164A4 (en) 2013-12-04
US9018439B2 (en) 2015-04-28

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