WO2011064164A1 - Nebulizer - Google Patents
Nebulizer Download PDFInfo
- Publication number
- WO2011064164A1 WO2011064164A1 PCT/EP2010/067902 EP2010067902W WO2011064164A1 WO 2011064164 A1 WO2011064164 A1 WO 2011064164A1 EP 2010067902 W EP2010067902 W EP 2010067902W WO 2011064164 A1 WO2011064164 A1 WO 2011064164A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nebulizer
- container
- housing part
- counter device
- operations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0073—Mechanical counters having a display or indicator on a ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0081—Locking means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
Definitions
- the container is pre-installed in nebulizer in the delivery state.
- the pre-installed container is held by a transportation lock unmovable within the housing in the delivery state in order to avoid any undesired opening of the container.
- the nebulizer Before being used for the first time the nebulizer is completely closed.
- the pre-installed container is opened by a delivery tube piercing a sealing and a septum to fluidically connect to the inner bag of the container. Further, the transportation lock is opened so that the container can move inside the nebulizer back and forth.
- Object of the present invention is to provide a nebulizer which can be used only with a predefined number of replaceable containers wherein a simple construction is possible and/or a defined handling is achieved.
- the present invention relates to a nebulizer which can be opened for inserting and replacing a container with the fluid to be nebulized.
- the nebulizer comprises a counter device for counting operations of the nebulizer.
- the counter device blocks opening of the nebulizer until a predetermined number of operations has been reached or exceeded. Thus, it can be prevented that the nebulizer is opened before the container has been (sufficiently) used or has been emptied. Thus, potential soiling of the nebulizer can be minimized and/or a defined handling can be secured.
- Fig. 2 a schematic section, rotated through 90° compared with Fig. 1, of the known nebulizer in a tensioned state;
- Fig. 4 a schematic section of the nebulizer according to Fig. 3 in an activated, tensioned state with the completely closed housing and with the opened container;
- Fig. 5 a schematic section of the nebulizer according to Fig. 4 in a non- tensioned state
- Fig. 6 a schematic section of a nebulizer with a partly closed housing and with a securing means in a housing part holding unmoveably a container in the nebulizer;
- Fig. 1 1 a perspective view of a control ring of the counter device
- Fig. 12 a perspective view of a control element of the counter device
- Fig. 13 a partial sectional view of the nebulizer without housing part, counter device and container;
- Figs. 1 and 2 show a known nebulizer 1 for atomizing a fluid 2, particularly a highly effective pharmaceutical composition or the like, diagrammatically shown in a non-tensioned state (Fig. 1) and in a tensioned state (Fig. 2).
- the nebulizer 1 is constructed in particular as a portable inhaler and preferably operates only mechanical and/or without propellant gas.
- the nebulizer 1 comprises preferably a pressure generator 5 for conveying and nebulizing the fluid 2, particularly in a preset and optionally adjustable dosage amount.
- the pressure generator 5 comprises preferably a holder 6 for the container 3, an associated drive spring 7, only partly shown, a locking element
- a conveying element such as a conveying tube 9, a non-return valve 10, a pressure chamber 1 1 and/or an nozzle 12 for nebulizing the fluid 2 into a mouthpiece 13.
- the container 3 is fixed or held in the nebulizer 1 via the holder 6 such that the conveying tube 9 penetrates into the container 3.
- the holder 6 may be constructed so that the container 3 can be exchanged.
- the housing part 18 can be rotated relative to the upper housing part 16, carrying with it the part 17b of the inner part 17.
- the drive spring 7 is tensioned in the axial direction by means of a gear or transmission (not shown) acting on the holder 6.
- the container 3 is moved axially downwards until the container 3 assumes an end position as shown in Fig. 2.
- the drive spring 7 is under tension.
- the container 3 is moved back into its original position (non-tensioned position or state shown in Fig. 1) by the drive spring 7.
- the container 3 executes a lifting or stroke movement during the tensioning process and during the atomizing process.
- the housing part 18 preferably forms a cap-like lower housing part and fits around or over a lower free end portion of the container 3.
- an aeration means such as an axially acting spring 20 arranged in the housing part 18, comes in contact with base 21 of the container 3 and pierces the container 3 or a base seal thereon with a piercing element 22 when the container 3 makes contact with it for the first time, to allow air in or aeration.
- the container 3 has been pre-installed, i.e. inserted into the nebulizer 1.
- the container 3 or its fluid outlet 24 is not yet opened.
- the second closure 26 is already opened, but not the first closure 25.
- the housing of the nebulizer 1 is closed only partly, i.e. not completely, in the delivery state, preferably by not completely closing or pushing on the housing part 18 in the shown embodiment.
- the housing part 18 is snapped on or inserted only partly in the delivery state.
- the securing member 30 is at least substantially hollow and/or cylindrical and is disposed axially between the (lower) housing part 18 and the upper housing part 16. To activate the nebulizer 1 or prepare its for use, i.e. to push the housing part 18 fully on in the axial direction and thereby open the container 3, the securing member 30 first has to be removed or released or opened.
- the securing member 30 is constructed in the manner of a banderole or the like, made of plastics, for example, and/or can be manually opened, removed or destroyed.
- the securing member 30 may alternatively or simultaneously form or constitute a seal of origin.
- other embodiments of the securing member 30 are also possible, e.g. in the form of a security tag or the like.
- the securing means 35 or base 38 comprises or holds the piercing element 22 for piercing the container 3, i.e. opening the container base 21 or its venting hole 34 in the activated and tensioned state, i.e. when the container 3 reaches its lower end position.
- the piercing element 22 is formed by a respective bending of a spring portion 39 of the securing means 35 or its base 38.
- the spring portion 39 can support or facilitate the (complete or final) connection of the container 3 to holder 6.
- the container end or edge 41 is caught between end portions 36a and 37a of the elements 36 and 37.
- the holding elements 36 grip or extend over the edge 41 and the locking elements 37 or its end portions 37a grip or extend under the edge 41 or container base 21 so that the edge 41 and container 3 are securely held preventing any axial movement of the container 3 relative to the securing means 35 and relative to the associated housing part 18 in this state, i.e. with locked securing means 35 / transportation lock 29.
- the end portions 36a of the holding elements 36 end in a first radial plane and the end portions 37a of the locking elements 37 end in another, second radial plane, wherein the two planes are axially offset to hold the edge 41 in between and/or wherein the second plane is located axially between the first plane and the lower end position of the container 3 or the lower end of the housing part 18 or the piercing element 22.
- the end portions 36a end on another radius (outer radius) than end portions 37a and/or axially spaced.
- the end portions 36a and/or 37a preferably form like claws or the like and/or extend preferably radially inwardly.
- the counter device 44 blocks opening of the nebulizer 1 until a predetermined number of operations has been reached or exceeded.
- the counter device 44 is associated to preferably only one container 3 and counts operations of the nebulizer 1 with the respective container 3, i.e. counts (only) the number of doses of fluid 2 removed or still removeable from this container 3.
- the counter device 44 blocks opening of the nebulizer 1 until a predetermined number of doses of the fluid 2 has been drawn or removed from the respective container 3.
- the counter device 44 counts the operations or uses of the respective container 3 in the nebulizer 1 and blocks opening of the nebulizer 1 until a predetermined number has been reached or exceeded.
- the counter device 44 comprises preferably a control element 50 which is shown in Fig. 10 and in a perspective view in Fig. 12.
- the control element 50 is preferably associated to the control means or control ring 45.
- the control element 50 comprises a biasing portion 51 , an engagement portion 52 and/or a locking portion 53.
- the control element 50 is axially moveable and/or guided by the housing part 18.
- the locking spring 58 is mounted in a pre- tensioned state such that it can radially expand and engage into a radial recess or the like when the locking spring 58 or part thereof is actuated or axially shifted (here by the rider 56 or its actuation portion 57) to lock the nebulizer 1 or interlock its parts 16 and 17.
- the locking spring 58 or part thereof is actuated or axially shifted (here by the rider 56 or its actuation portion 57) to lock the nebulizer 1 or interlock its parts 16 and 17.
- other constructional solutions are possible as well.
- the rider 56, the locking spring 58, the upper housing part 16, the lower housing part 18 and the control element 50 are not shown in Fig. 14.
- the inner toothing 46 is preferably axially open to enable an axial connection and disconnection with the associated drive gear 60 as shown in Fig. 14.
- the nebulizer 1 When the housing of the nebulizer 1 is completely closed, i.e. the lower housing part 18 is completely pushed on the inner part 17, the nebulizer 1, in particular the locking member 61 , interlocks preferably automatically with the lower housing part 18, the counter device 44 or its control ring 45.
- This can be achieved in that the locking member 61 flexes radially, in particular inwardly due to the interaction of a respectively inclined guiding surface 62 with the control ring 45 or ridge 49.
- the locking member 61 has passed the control ring 45 or ridge 49, it can flex back and grip under the control ring 45 or ridge 49 so that the nebulizer 1 or its housing is blocked against opening (this state is also called blocking state or secured state).
- the interlocking of the housing part 18 with the nebulizer 1 is preferably released or unblocked when CCB is reached or activated or vice versa.
- control element 50 or its engagement portion 52 blocks the control ring 45 against further rotation, because the engagement portion 52 engages into the control recess 52 in the blocking position of the control element 50.
- the monitoring device 23 does not lock the nebulizer 1 against further use. Therefore, the nebulizer 1 can be used with multiple container 3, e.g. 2, 3, 4 or 5 containers 3, one after the other until the LSB value is reached or exceeded and the nebulizer 1 is locked against further use.
- the counter device 44 can display or indicate the number of operations or uses of the nebulizer 1 with the respective container 3 already performed or still possible.
- the control ring 45 is preferably molded and/or made of plastics.
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2010323220A AU2010323220B2 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
SG2012038410A SG181050A1 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
UAA201207260A UA107097C2 (en) | 2009-11-25 | 2010-11-22 | Dispenser |
AP2012006207A AP3141A (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
KR1020127016237A KR101782306B1 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
EA201200775A EA026241B1 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
CN201080052884.5A CN102686260B (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
MX2012005961A MX2012005961A (en) | 2009-11-25 | 2010-11-22 | Nebulizer. |
BR112012012475-7A BR112012012475B1 (en) | 2009-11-25 | 2010-11-22 | NEBULIZER |
NZ599295A NZ599295A (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
JP2012540382A JP5715640B2 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
EP10781681.1A EP2504052B1 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
CA2781792A CA2781792C (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
IL219088A IL219088A (en) | 2009-11-25 | 2012-04-05 | Nebulizer |
ZA2012/02598A ZA201202598B (en) | 2009-11-25 | 2012-04-11 | Nebulizer |
MA34875A MA33755B1 (en) | 2009-11-25 | 2012-05-16 | Sprayer |
TNP2012000245A TN2012000245A1 (en) | 2009-11-25 | 2012-05-21 | Nebulizer |
HK13102847.6A HK1175418A1 (en) | 2009-11-25 | 2013-03-07 | Nebulizer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09014680.4 | 2009-11-25 | ||
EP09014680 | 2009-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011064164A1 true WO2011064164A1 (en) | 2011-06-03 |
Family
ID=43838122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/067902 WO2011064164A1 (en) | 2009-11-25 | 2010-11-22 | Nebulizer |
Country Status (27)
Country | Link |
---|---|
US (1) | US9724482B2 (en) |
EP (1) | EP2504052B1 (en) |
JP (1) | JP5715640B2 (en) |
KR (1) | KR101782306B1 (en) |
CN (2) | CN102686260B (en) |
AP (1) | AP3141A (en) |
AR (1) | AR079154A1 (en) |
AU (1) | AU2010323220B2 (en) |
BR (1) | BR112012012475B1 (en) |
CA (1) | CA2781792C (en) |
CL (1) | CL2012001359A1 (en) |
CO (1) | CO6551692A2 (en) |
EA (1) | EA026241B1 (en) |
EC (1) | ECSP12011986A (en) |
HK (1) | HK1175418A1 (en) |
IL (1) | IL219088A (en) |
MA (1) | MA33755B1 (en) |
MX (1) | MX2012005961A (en) |
NZ (1) | NZ599295A (en) |
PE (1) | PE20130036A1 (en) |
SG (1) | SG181050A1 (en) |
TN (1) | TN2012000245A1 (en) |
TW (1) | TW201129399A (en) |
UA (1) | UA107097C2 (en) |
UY (1) | UY33054A (en) |
WO (1) | WO2011064164A1 (en) |
ZA (1) | ZA201202598B (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015169732A1 (en) * | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
WO2015169431A3 (en) * | 2014-05-07 | 2015-12-30 | Boehringer Ingelheim International Gmbh | Nebulizer, indicator device and container |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
WO2022002993A1 (en) | 2020-07-03 | 2022-01-06 | Boehringer Ingelheim International Gmbh | Nebulizer |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101345770B1 (en) * | 2012-04-20 | 2013-12-27 | (주)연우 | A nose washer |
GB2507104A (en) | 2012-10-19 | 2014-04-23 | Nicoventures Holdings Ltd | Electronic inhalation device |
US20150041558A1 (en) * | 2013-08-09 | 2015-02-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
ES2960809T3 (en) * | 2013-08-20 | 2024-03-06 | Boehringer Ingelheim Vetmedica Gmbh | Inhaler |
GB201517089D0 (en) | 2015-09-28 | 2015-11-11 | Nicoventures Holdings Ltd | Vaping heat map system and method for electronic vapour provision systems |
TWI565531B (en) * | 2015-11-25 | 2017-01-11 | Motedo Co Ltd | Safe use of the sprayer |
EP3175722A1 (en) * | 2015-12-03 | 2017-06-07 | JT International S.A. | Inhaler device and consumable cartridge for same |
US11369760B2 (en) * | 2016-08-24 | 2022-06-28 | Anovent Pharmaceutical (U.S.), Llc | Inhalation atomizer comprising a blocking function and a counter |
CN111195382B (en) * | 2018-11-16 | 2022-04-19 | 微邦科技股份有限公司 | Locking structure of atomization drug delivery device |
TWI683677B (en) * | 2018-11-16 | 2020-02-01 | 微邦科技股份有限公司 | Locking structure of atomized drug delivery device |
AU2020281583A1 (en) * | 2019-05-24 | 2021-12-23 | Boehringer Ingelheim Vetmedica Gmbh | Inhalers as well as protective device and breath indicator |
CN115768294B (en) * | 2020-01-16 | 2024-04-02 | 汽化技术公司 | Personal vaporizer for use with vials |
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