WO2011060553A1 - Formulation et procédé de préparation rapide de solutions de chitosane isotoniques et cytocompatibles sans provocation de la précipitation du chitosane - Google Patents

Formulation et procédé de préparation rapide de solutions de chitosane isotoniques et cytocompatibles sans provocation de la précipitation du chitosane Download PDF

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Publication number
WO2011060553A1
WO2011060553A1 PCT/CA2010/001856 CA2010001856W WO2011060553A1 WO 2011060553 A1 WO2011060553 A1 WO 2011060553A1 CA 2010001856 W CA2010001856 W CA 2010001856W WO 2011060553 A1 WO2011060553 A1 WO 2011060553A1
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WO
WIPO (PCT)
Prior art keywords
cytocompatible
chitosan
salt
polymer composition
polymer
Prior art date
Application number
PCT/CA2010/001856
Other languages
English (en)
Inventor
Caroline Hoemann
Jun Sun
Original Assignee
Corporation De L'ecole Polytechnique De Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corporation De L'ecole Polytechnique De Montreal filed Critical Corporation De L'ecole Polytechnique De Montreal
Publication of WO2011060553A1 publication Critical patent/WO2011060553A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un système cytocompatible en deux parties pour la préparation d'une composition cytocompatible destinée à une utilisation dans la réparation tissulaire d'un sujet. Le système comprend le mélange d'une solution liquide en première partie d'un polysaccharide, tel que le chitosane et une solution liquide en seconde partie d'un sel, tel que le phosphate de glycérol. Lorsque les solutions de chitosane et de phosphate de glycérol sont combinées, il est produit une composition cytocompatible qui est dépourvue de précipitation de polymère à température ambiante. La composition active également la formation de complexes non covalents entre le chitosane et des protéines anioniques thérapeutiques avec un pl < 6 78.
PCT/CA2010/001856 2009-11-19 2010-11-19 Formulation et procédé de préparation rapide de solutions de chitosane isotoniques et cytocompatibles sans provocation de la précipitation du chitosane WO2011060553A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26280809P 2009-11-19 2009-11-19
US61/262,808 2009-11-19

Publications (1)

Publication Number Publication Date
WO2011060553A1 true WO2011060553A1 (fr) 2011-05-26

Family

ID=44059164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2010/001856 WO2011060553A1 (fr) 2009-11-19 2010-11-19 Formulation et procédé de préparation rapide de solutions de chitosane isotoniques et cytocompatibles sans provocation de la précipitation du chitosane

Country Status (1)

Country Link
WO (1) WO2011060553A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017009346A1 (fr) 2015-07-13 2017-01-19 Kiomed Pharma Chitosane pour mélange avec un fluide coagulable
US10758623B2 (en) 2013-12-09 2020-09-01 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007416A1 (fr) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. FORMATION, TRIBUTAIRE DU pH, ET A TEMPERATURE CONTROLEE, DE GELS DE POLYSACCHARIDE IONIQUE
US20070037737A1 (en) * 2000-06-29 2007-02-15 Hoemann Caroline D Composition and method for the repair and regeneration of cartilage and other tissues
CA2672936A1 (fr) * 2006-11-30 2008-06-05 Bio Syntech Canada Inc. Methode de solidification in situ de compositions sang-polymere pour medecine regenerative et applications de reparation du cartilage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007416A1 (fr) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. FORMATION, TRIBUTAIRE DU pH, ET A TEMPERATURE CONTROLEE, DE GELS DE POLYSACCHARIDE IONIQUE
US20070037737A1 (en) * 2000-06-29 2007-02-15 Hoemann Caroline D Composition and method for the repair and regeneration of cartilage and other tissues
CA2672936A1 (fr) * 2006-11-30 2008-06-05 Bio Syntech Canada Inc. Methode de solidification in situ de compositions sang-polymere pour medecine regenerative et applications de reparation du cartilage

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHMADI, R. ET AL.: "Biocompatibility and gelation of chitosan-glvcerol phosphate hydrogels", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PARTA, vol. 86, 2008, pages 824 - 832, XP055159287, DOI: doi:10.1002/jbm.a.31676 *
CHO, M.H. ET AL.: "Chitosan Gel as an In Situ-Forming Scaffold for Rat Bone Marrow Mesenchymal Stem Cells In Vivo", TISSUE ENGINEERING: PART A, vol. 14, 2008, pages 1099 - 1108 *
ILIESCU, M. ET AL.: "Ultrastructure of Hybrid Chitosan-Glycerol Phosphate Blood Clots by Environmental Scanning Electron Microscopy", MICROSCOPY RESEARCH AND TECHNIQUE, vol. 71, 2008, pages 236 - 247 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10758623B2 (en) 2013-12-09 2020-09-01 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
US11529420B2 (en) 2013-12-09 2022-12-20 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
WO2017009346A1 (fr) 2015-07-13 2017-01-19 Kiomed Pharma Chitosane pour mélange avec un fluide coagulable

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