WO2011056985A3 - Composés hétérocycliques substitués - Google Patents

Composés hétérocycliques substitués Download PDF

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Publication number
WO2011056985A3
WO2011056985A3 PCT/US2010/055467 US2010055467W WO2011056985A3 WO 2011056985 A3 WO2011056985 A3 WO 2011056985A3 US 2010055467 W US2010055467 W US 2010055467W WO 2011056985 A3 WO2011056985 A3 WO 2011056985A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
substituted heterocyclic
heterocyclic compounds
relates
diabetes
Prior art date
Application number
PCT/US2010/055467
Other languages
English (en)
Other versions
WO2011056985A2 (fr
Inventor
Matthew Abelman
Nancy Chu
Robert Jiang
Jeff Zablocki
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of WO2011056985A2 publication Critical patent/WO2011056985A2/fr
Publication of WO2011056985A3 publication Critical patent/WO2011056985A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Abstract

La présente invention porte sur des composés qui sont des inhibiteurs de canaux sodiques et sur leur utilisation dans le traitement de divers états de maladie, comprenant les maladies cardiovasculaires et le diabète. Dans des modes de réalisation particuliers, la structure des composés est donnée par la Formule (I) telle que décrite en détail présentement. L'invention porte également sur des procédés pour la préparation des composés, et sur des compositions pharmaceutiques contenant de tels composés.
PCT/US2010/055467 2009-11-04 2010-11-04 Composés hétérocycliques substitués WO2011056985A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25813209P 2009-11-04 2009-11-04
US61/258,132 2009-11-04

Publications (2)

Publication Number Publication Date
WO2011056985A2 WO2011056985A2 (fr) 2011-05-12
WO2011056985A3 true WO2011056985A3 (fr) 2011-10-27

Family

ID=43416386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/055467 WO2011056985A2 (fr) 2009-11-04 2010-11-04 Composés hétérocycliques substitués

Country Status (1)

Country Link
WO (1) WO2011056985A2 (fr)

Families Citing this family (24)

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WO2012049555A1 (fr) 2010-10-13 2012-04-19 Lupin Limited Composés spirocycliques en tant que modulateurs de canaux sodiques dépendants du voltage
TWI510480B (zh) 2011-05-10 2015-12-01 Gilead Sciences Inc 充當離子通道調節劑之稠合雜環化合物
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (fr) 2011-07-01 2018-04-28
CN102491979A (zh) * 2011-12-21 2012-06-13 天津科技大学 一种1-羟乙基-5-取代吲哚酮类衍生物及其制备方法以及应用
WO2013112932A1 (fr) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Thérapies de combinaison à l'aide de bloqueurs de canaux ioniques au sodium tardifs et de bloqueurs de canaux ioniques au potassium
AU2015242219A1 (en) 2014-03-29 2016-10-06 Lupin Limited Sulfonamide compounds as Voltage gated sodium channel modulators
AU2016255431B2 (en) 2015-04-29 2020-05-07 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
WO2016176449A1 (fr) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Composés de benzimidazolone et de benzothiazolone et leur utilisation comme modulateurs des récepteurs ampa
CN107835814B (zh) 2015-04-29 2021-07-23 詹森药业有限公司 氮杂苯并咪唑及其作为ampa受体调节剂的用途
CN107750250B (zh) * 2015-04-29 2021-09-07 詹森药业有限公司 吲哚酮化合物及其作为ampa受体调节剂的用途
TW201722938A (zh) 2015-09-04 2017-07-01 魯賓有限公司 作為電位閘控鈉通道調節子之磺醯胺化合物
JP7105797B2 (ja) 2016-11-28 2022-07-25 プラクシス プレシジョン メディシンズ， インコーポレイテッド 化合物及びその使用方法
US11261188B2 (en) 2016-11-28 2022-03-01 Praxis Precision Medicines, Inc. Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel
US11492345B2 (en) 2017-02-13 2022-11-08 Praxis Precision Medicines, Inc. Compounds and their methods of use
WO2018163077A1 (fr) 2017-03-08 2018-09-13 Lupin Limited Composés indanyle utilisés en tant que modulateurs de canaux sodiques dépendant de la tension
WO2018187480A1 (fr) 2017-04-04 2018-10-11 Praxis Precision Medicines, Inc. Composés et leurs méthodes d'utilisation
US11278535B2 (en) 2017-08-15 2022-03-22 Praxis Precision Medicines, Inc. Compounds and their methods of use
TWI831786B (zh) 2018-05-30 2024-02-11 美商普雷西斯精密藥品公司 離子通道調節劑
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
CN116813525B (zh) * 2023-08-28 2023-11-21 苏州爱玛特生物科技有限公司 一种多乙酰基取代的氧化吲哚类化合物的合成方法

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