WO2011047387A3 - Planification du traitement pour les thérapies par électroporation - Google Patents

Planification du traitement pour les thérapies par électroporation Download PDF

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Publication number
WO2011047387A3
WO2011047387A3 PCT/US2010/053077 US2010053077W WO2011047387A3 WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3 US 2010053077 W US2010053077 W US 2010053077W WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
electroporation
based therapies
methods
devices
Prior art date
Application number
PCT/US2010/053077
Other languages
English (en)
Other versions
WO2011047387A2 (fr
Inventor
Robert E. Neal
Paulo A. Garcia
Rafael V. Davalos
John H. Rossmeisl
John L. Robertson
Original Assignee
Virginia Tech Intellectual Properties, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties, Inc. filed Critical Virginia Tech Intellectual Properties, Inc.
Priority to EP10824248.8A priority Critical patent/EP2488251A4/fr
Publication of WO2011047387A2 publication Critical patent/WO2011047387A2/fr
Publication of WO2011047387A3 publication Critical patent/WO2011047387A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)

Abstract

Cette invention concerne des systèmes, des procédés, et des dispositifs pour les thérapies par électroporation (EBT). Les modes de réalisation comprennent des protocoles de traitement spécifiques du patient dérivés par modélisation numérique de reconstructions 3D du tissu cible à partir d'images dudit tissu, prenant éventuellement en compte une ou plusieurs contraintes physiques ou propriétés dynamiques du tissu. Cette invention concerne, en outre, des systèmes, des procédés et des dispositifs permettant de délivrer des impulsions électriques bipolaires dans le cadre d'une électroporation irréversible induisant peu, voire aucun des dommages tissulaires typiquement associés à la charge excessive délivrée au tissu et induite par l'EBT.
PCT/US2010/053077 2009-10-16 2010-10-18 Planification du traitement pour les thérapies par électroporation WO2011047387A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10824248.8A EP2488251A4 (fr) 2009-10-16 2010-10-18 Planification du traitement pour les thérapies par électroporation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25244509P 2009-10-16 2009-10-16
US61/252,445 2009-10-16

Publications (2)

Publication Number Publication Date
WO2011047387A2 WO2011047387A2 (fr) 2011-04-21
WO2011047387A3 true WO2011047387A3 (fr) 2011-09-29

Family

ID=43876931

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/053077 WO2011047387A2 (fr) 2009-10-16 2010-10-18 Planification du traitement pour les thérapies par électroporation

Country Status (2)

Country Link
EP (1) EP2488251A4 (fr)
WO (1) WO2011047387A2 (fr)

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US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US9598691B2 (en) 2008-04-29 2017-03-21 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
WO2010118387A1 (fr) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Intégration d'impulsions électriques très courtes pour une électroporation invasive de façon minimale à non invasive
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010138919A2 (fr) 2009-05-28 2010-12-02 Angiodynamics, Inc. Système et méthode de synchronisation de l'apport d'énergie et du rythme cardiaque
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2012051433A2 (fr) 2010-10-13 2012-04-19 Angiodynamics, Inc. Système et procédé d'ablation électrique des tissus chez un patient
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
RU2524194C2 (ru) * 2012-06-07 2014-07-27 Андрей Леонидович Шпади Способ лечения раковых опухолей
WO2014149728A1 (fr) * 2013-03-15 2014-09-25 Empi, Inc. Guidage à base d'image personnalisée pour dispositifs thérapeutiques basés sur l'énergie
EP3143124A4 (fr) 2014-05-12 2018-01-17 Virginia Tech Intellectual Properties, Inc. Modulation sélective des effets intracellulaires des cellules à l'aide de champs électriques pulsés
CN106459858B (zh) 2014-07-28 2018-01-30 内帕基因株式会社 电穿孔用电脉冲发生器和具备所述电脉冲发生器的电穿孔装置
WO2016100325A1 (fr) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Dispositifs, systèmes et méthodes de surveillance en temps réel d'effets électrophysiologiques au cours d'un traitement tissulaire
PL3277368T3 (pl) * 2015-03-31 2021-01-25 Oncosec Medical Incorporated Układy do ulepszonej elektroporacji opartej na wykrywaniu tkanek
CN108135653B (zh) 2015-10-07 2022-02-11 梅约医学教育与研究基金会 用于肥胖症或糖尿病治疗的电穿孔
EP4209190A1 (fr) 2016-06-27 2023-07-12 Galvanize Therapeutics, Inc. Système comprenant un générateur et un cathéter avec une électrode pour traiter un passage pulmonaire
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
BR112020025269A2 (pt) * 2018-07-18 2021-03-09 Novocure Gmbh Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields)
CN110135073B (zh) * 2019-05-17 2023-06-16 沈阳大学 一种超高强铝合金脉冲电流调控铸轧模拟方法
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
JP2023503400A (ja) * 2019-12-02 2023-01-30 ノボキュア ゲーエムベーハー トランスデューサアレイ載置を最適化するための方法および装置
JP2023508584A (ja) 2019-12-31 2023-03-02 ノボキュア ゲーエムベーハー 画像セグメンテーションのための方法、システム、および装置
WO2023167747A2 (fr) * 2021-11-26 2023-09-07 Old Dominion University Research Foundation Stimulation focale améliorée par sommation spatio-temporelle d'impulsions électriques de nanoseconde

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US6482619B1 (en) * 1999-07-21 2002-11-19 The Regents Of The University Of California Cell/tissue analysis via controlled electroporation
US20040009459A1 (en) * 2002-05-06 2004-01-15 Anderson James H. Simulation system for medical procedures
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging

Non-Patent Citations (1)

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See also references of EP2488251A4 *

Also Published As

Publication number Publication date
EP2488251A4 (fr) 2014-02-19
WO2011047387A2 (fr) 2011-04-21
EP2488251A2 (fr) 2012-08-22

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