WO2011044758A1 - 食道酸碱度无线监测定位系统、装置及方法 - Google Patents
食道酸碱度无线监测定位系统、装置及方法 Download PDFInfo
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- WO2011044758A1 WO2011044758A1 PCT/CN2010/001623 CN2010001623W WO2011044758A1 WO 2011044758 A1 WO2011044758 A1 WO 2011044758A1 CN 2010001623 W CN2010001623 W CN 2010001623W WO 2011044758 A1 WO2011044758 A1 WO 2011044758A1
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- vivo sensing
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- vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
- A61B5/062—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4233—Evaluating particular parts, e.g. particular organs oesophagus
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B7/00—Radio transmission systems, i.e. using radiation field
- H04B7/24—Radio transmission systems, i.e. using radiation field for communication between two or more posts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
- A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
- A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
Definitions
- the invention relates to the technical field of medical instruments, in particular to a system, a device and a method for wireless detection of the esophageal acid-base (PH) degree.
- PH esophageal acid-base
- esophageal diseases include reflux esophagitis, esophageal cancer, esophageal stricture, esophageal varices, indigestion, Functional dysphagia, etc., bring pain to people.
- the prior art also includes a catheter-type physiological parameter monitor, such as a catheter type P H meter, a catheter type manometer, a catheter type bilirubin meter, and the like, which all require catheter indwelling, which makes people feel painful and embarrassed. Can not eat, it is difficult to use for a long time.
- a catheter-type physiological parameter monitor such as a catheter type P H meter, a catheter type manometer, a catheter type bilirubin meter, and the like, which all require catheter indwelling, which makes people feel painful and embarrassed. Can not eat, it is difficult to use for a long time.
- the patient can inevitably change the position of the data recorder during work and rest, which may cause signal interruption, thereby affecting the integrity of the test.
- Embodiments of the present invention provide a wireless monitoring and positioning system, device and method for esophagus pH to avoid ineffective detection caused by accidental shedding of the capsule, and at the same time reduce the detection cost of the patient.
- the embodiment of the present invention provides an esophageal pH wireless monitoring and positioning system, comprising: an in vivo sensory transmitting device 30 and an in vitro detecting and recording device 20;
- the in-vivo detection transmitting device 30 includes: a pH sensor 301, a sampling circuit 302, a first microprocessor 303, a power management 305, a first wireless transceiver module 304, and a first device 307, wherein the external detection recording device 20 includes a second microprocessor 201, a power management 210, a buzzer 209, a memory 205, a data interface 206, a button 207, a second wireless transceiver module 204; a status indicator 208, a housing 211, and a second device 203;
- the second device 203 in the in-vitro detection recording device 20 cooperates with the first device 307 in the in-vivo sensing transmitting device 30, and if the in-vivo detecting recording device 20 detects that the in-vivo sensing transmitting device 30 is outside the specified range, then in the micro An alarm signal is sent by the buzzer 209 and/or the status indicator 208 under the control of the processor 201;
- the in vitro detection and recording device 20 periodically collects the signal strength of the signal received by the second wireless transceiver module 204 under the control of the microprocessor 201. If the signal strength is detected to exceed the specified signal strength range, the microprocessor is in the microprocessor. An alarm signal is issued by the buzzer 209 and/or the status indicator 208 under the control of 201.
- the first device 307 of the in-vivo sensing device 30 is a permanent magnet;
- the second device 203 in the external detection recording device 20 is a magnetic sensor;
- the second device 203 in the in-vivo detection recording device 20 cooperates with the first device 307 in the in-vivo sensing device 30, and specifically includes: testing the magnetic field strength generated by the permanent magnet in the in-vivo sensing device 30 by using a magnetic sensor. If the magnetic field strength is outside the specified range, the extracorporeal detection recording device 20 detects that the in-vivo sensing transmitting device 30 is out of the specified range.
- the first device 307 of the in-vivo sensing device 30 is a reed switch, and the oboe is connected in series between the pH sensor 301 and the sampling circuit 302;
- the second device 203 in the in vitro detection recording device 20 is a magnet; the reed switch is opened and closed by the magnet induction control;
- the second device 203 in the in-vivo detection recording device 20 cooperates with the first device 307 in the in-vivo sensing device 30, and specifically includes: if the magnet and the reed switch exceed a preset distance, then The reed switch opens and disconnects the circuit between the pH sensor 301 and the sampling circuit 302 in the in vivo sensing device 30, and the in vitro detection recording device 20 monitors that the in vivo sensing device 30 is out of the specified range.
- the in-vivo detection and recording device 20 further includes a temperature sensor 202, wherein the memory 205 pre-stores the pH calibration factory data of the in-vivo sensing device 30; the temperature sensor 202 collects the current ambient temperature and transmits The second wireless transceiver module 204 receives the initial data from the in-vivo sensing transmitting device 30 and transmits the data to the microprocessor 201.
- the second microprocessor 201 calibrates the initial data, performs temperature compensation during the calibration process, obtains current calibration data, and applies the current calibration data to a pre-stored pH in the memory 205. Calibrating the factory data for comparison, if not, transmitting a calibration alarm signal to the in-vivo sensing transmitting device 30 through the second wireless transceiver module 204;
- the in-vivo sensing device 30 further includes a work indicator 306;
- the first wireless transceiver module 304 of the in-vivo sensor transmitting device 30 receives the calibration alarm signal and transmits it to the first microprocessor 303;
- the first microprocessor 303 controls the work indicator 306 to issue a calibration alarm signal.
- the embodiment of the present invention further provides an in-vivo sensing transmitting device, including: a pH sensor 301, a sampling circuit 302, a first micro processor 303, a power management 305, and a first wireless transceiver module 304.
- the pH sensor 301, the sampling circuit 302, the first microprocessor 303, and the first wireless transceiver module 304 are sequentially connected in series, and the power management 305 and the pH sensor 301, the sampling circuit 302, and the first microprocessor are connected in series.
- the sampling circuit 302, the first microprocessor 303, the power management 305, and the first wireless transceiver module 304 are sealed in a casing 308, and the sensing of the pH sensor 301 Partially exposed to the outside of the capsule housing 308, capable of contacting the body fluid of the esophagus, the in vivo sensor transmitting device further comprising:
- a first device 307 is disposed within the outer casing 308.
- the first device 307 is a permanent magnet, or
- the first device 307 is a reed switch connected in series between the pH sensor 301 and the sampling circuit 302.
- the device further includes: a work indicator 306 connected to the first pattern processor 303, and receiving a control signal from the first microprocessor 303 to issue a calibration alarm signal.
- the embodiment of the present invention further provides an external detection and recording device, including: a second microprocessor 201, a power management 210, a buzzer 209, a memory 205, a data interface 206, a button 207, and a second wireless transceiver module 204; An indicator light 208, a housing 211, and a second device 203,
- the second device 203 cooperates with the first device 307 in the in-vivo sensing transmitting device 30, and if the in-vivo sensing transmitting device 30 is monitored beyond the specified range, the buzz is passed under the control of the second microprocessor 201. 209 and/or status indicator 208 signals an alarm;
- the in vitro detection and recording device 20 periodically collects the signal strength of the signal received by the second wireless transceiver module 204 under the control of the microprocessor 201. If the signal strength is detected to exceed the specified signal strength range, the microprocessor is in the microprocessor. An alarm signal is issued by the buzzer 209 and/or the status indicator 208 under the control of 201.
- the in-vivo detection recording device 20 further includes a temperature sensor 202, wherein the memory 205 pre-stores the pH calibration factory data of the in-vivo sensing transmitting device 30; the temperature sensor 202 collects the current ambient temperature, Transfer to the second microprocessor
- the second wireless transceiver module 204 receives initial data from the in-vivo sensing transmitting device 30 and transmits it to the second microprocessor 201, and the second microprocessor 201 calibrates the initial data, and in the Perform temperature compensation during calibration to obtain current calibration data, apply The current calibration data is compared with the pH calibration factory data pre-stored in the memory 205. If not, the calibration alarm message is sent to the in-vivo sensor transmitting device 30 through the second wireless transceiver module 204.
- the embodiment further provides a The esophageal pH wireless monitoring and positioning method is used between the external detection recording device 20 and the in vivo sensing transmitting device 30, and includes:
- the in-vivo detection recording device 20 cooperates with the in-vivo sensing transmitting device 30 to determine whether the position of the in-vivo sensing transmitting device 30 is within a specified range, and if not, to issue an alarm signal;
- the extracorporeal detection recording device 20 periodically collects the signal strength of the received signal, determines whether the signal strength is within a specified signal strength range, and if not, issues an alarm signal.
- the method further includes: before the actual application, the method further includes:
- the pH calibration factory data of the in vivo sensing transmitting device 30 is pre-stored in the in vitro detection recording device 20;
- the in vitro detection recording device 20 receives initial data from the in vivo sensing transmitting device 30, calibrates the initial data, and performs temperature compensation during the calibration process to obtain current calibration data, applying the current calibration The data is compared with pre-stored pH calibration factory data, and if different, a calibration alarm signal is sent to the in vivo sensing transmitter 30;
- the in-vivo sensing transmitting device 30 After receiving the calibration alarm signal, the in-vivo sensing transmitting device 30 sends a calibration alarm signal to apply the esophageal acid reduction wireless monitoring positioning system, device and method provided by the embodiment of the present invention, and the in vivo sensing transmitting device 30
- the cooperation of a device 307 and the second device 203 in the external detection recording device 20 realizes real-time monitoring of the position in the esophagus 1 of the in vivo sensing transmitting device; avoids invalid detection caused by accidental dropping of the plastic capsule, and reduces the detection cost of the patient.
- the detection of the received signal strength by the in-vivo sensing transmitting device 30 avoids the signal interruption problem that the patient may cause during work and rest, thereby ensuring the integrity of the detected data.
- FIG. 1 is a schematic diagram of a use state reference according to an embodiment of the present invention.
- FIG. 2 is a block diagram showing the circuit structure of an in-vivo sensing and transmitting device according to an embodiment of the present invention
- FIG. 3 is a block diagram showing the circuit structure of an in vitro detecting and recording device according to an embodiment of the present invention
- FIG. 5 is a flowchart of realizing the positioning of the in-vivo sensing transmitting device according to an embodiment of the present invention
- FIG. 6 is a flowchart of implementing a communication failure alarm according to an embodiment of the present invention
- the in-vivo sensing transmitting device 30 is fixed on the esophagus 10, and the in-vivo sensing transmitting device 30 performs data transmission by the radio frequency technology and the external detecting recording device 20.
- the in-vivo detection and emission device 30 may be a pH capsule, and the pH capsule is a streamlined flat capsule structure; the in vitro detection and recording device 20 may be a data recorder.
- the in vivo sensor emitting device is used as a pH capsule as an example.
- the pH capsule includes: a pH sensor 301, a sampling circuit 302, a first microprocessor 303, a power management 305, a first wireless transceiver module 304, wherein the pH sensor 301, the sampling circuit 302, the first microprocessor 303, and the A wireless transceiver module 304 is connected in series, and the power management 305 is respectively connected to the pH sensor 301, the sampling circuit 302, the first micro processor 303, and the first wireless transceiver module 304.
- the sampling circuit 302 and the first microprocessor are respectively connected.
- the power management 305, the first wireless transceiver module 304 is sealed within a plastic housing 308, and the sensing portion of the pH sensor 301 is exposed to the plastic housing
- the exterior of the 308 is capable of contacting body fluids of the esophagus, and the capsule further comprises: a first device 307 disposed within the capsule housing 308.
- the pH capsule shown in FIG. 2 is under the control of the first microprocessor 303, wherein the pH sensor 301 measures the pH of the liquid in the esophagus at a certain frequency, and the pH value collected by the sampling circuit 302 is converted into a digital signal.
- the first microprocessor 303 temporarily stored in the capsule transmits the data packet to the external data recorder, that is, the external detection recording device 20, by using the first wireless transceiver module 304 at intervals.
- the power management can be 305 using a 3V silver oxide button battery
- the first micro processor 303 can use a chip with built-in A/D and RAM
- the ⁇ ⁇ sensor 301 is composed of a medical ⁇ measuring electrode and an Ag/AgCl reference electrode
- the sampling circuit 302 After the impedance matching, signal amplification and filtering are performed by the micro op amp, the A/D is built in via the first microprocessor 303 for data acquisition, and then the dedicated first wireless transceiver module 304 is used to transmit the data to the external data logger.
- the first wireless transceiver module 304 and the external data logger can pass the FSK/ASK communication mode and adopt the European 433 MHz ISM band.
- the first wireless transceiver module 304 described above includes a power amplifier PA function.
- the first device 307 is a permanent magnet that does not contact any of the devices within the housing 308.
- the material of the permanent magnet is neodymium iron boron, aluminum nickel cobalt or other high magnetic energy product magnetic material; the permanent magnet is a sheet-like structure, and the magnetization direction is the thickness direction.
- the embodiment shown in FIG. 2 may further include a work indicator light 306 connected to the first microprocessor 303, and receiving a control signal of the first microprocessor 303 to issue a calibration alarm letter.
- the first device may also be a reed switch. In this case, the reed switch is connected in series between the pH sensor 301 and the sampling circuit 302.
- FIG. 3 is a block diagram showing the circuit configuration of an external detection recording apparatus according to an embodiment of the present invention.
- an in vitro detection and recording device is taken as an example of a data recorder.
- the data logger includes: a second microprocessor 201, a power management 210, a buzzer 209, a memory 205, a data interface 206, a button 207, a second wireless transceiver module 204; a status indicator 208, a data logger housing 211, and The second device 203; except for the button 207, all of the above components are mounted in the housing 211 of the data logger.
- the second wireless transceiver module 204 receives the pH data transmitted by the pH capsule 30, and temporarily stores the pH data in the memory 205 under the control of the second microprocessor 201, or Exported through data interface 206.
- the computer controls the time synchronization of the recorder, pH calibration, etc. through the data interface 206.
- the outer casing 22 of the data logger is made of a material that is non-toxic and harmless to the human body; the patient uses the button 207 on the data logger to record events such as eating, sleeping, lying, heartache, etc. during operation; data logger
- the memory 205 is used to store pH data that can be transferred between the data interface 16 and a data processing device such as a computer.
- the power management 210 can employ three 7# ordinary alkaline dry batteries.
- the memory 205 is a nonvolatile memory including Flash, Fram, EEPROM, and the like.
- the status indicator 208 can be a red, green, yellow LED or other display device.
- the second device 203 in FIG. 3 cooperates with the first device 307 in the in-vivo sensing transmitting device 30. If the in-vivo sensing transmitting device 30 is monitored within the specified range, the normal in-vivo sensing transmitting device 30 passes the first The data sent by the wireless transceiver module 304, if it is detected that the in-vivo sensing transmitting device 30 is out of the specified range, sends an alarm signal through the buzzer 209 and/or the status indicator 208 under the control of the second microprocessor 201;
- the second device 203 in the external detecting recording device 20 is a magnetic sensor that monitors the magnetic field of the capsule permanent magnet carrier, and the second device 203 is The cooperation of the first device 307 in the in-vivo sensor transmitting device 30 specifically means that if the magnetic field strength is within a specified magnetic field strength range, the external detecting and recording device 20 monitors that the in-vivo sensing transmitting device 30 is within a specified range; If the magnetic field strength exceeds the specified range, the extracorporeal detection recording device 20 monitors that the in-vivo sensing transmitting device 30 is out of the specified range.
- the first device 307 of the in-vivo sensing device 30 is a reed switch
- the second device 203 in the external detecting recording device 20 is a magnet
- the reed switch is controlled to open and close by the magnet
- the second device 203 and the body are transmitted
- the first device 307 in the sensing device 30 specifically means that if the magnet and the reed switch are within a predetermined distance, the reed switch is closed to turn on the pH of the in vivo sensing device 30.
- the circuit between the sensor 301 and the sampling circuit 302, the external detecting and recording device 20 detects that the in-vivo sensing transmitting device 30 is within a specified range; if the magnet and the reed switch exceed a preset distance, the reed spring
- the tube opens and disconnects the circuit between the pH sensor 301 and the sampling circuit 302 in the in-vivo sensing device 30, and the in-vivo detecting and recording device 20 monitors that the in-vivo sensing device 30 is out of the specified range.
- the external detection recording device 20 is under the control of the microprocessor 201, and periodically collects the second
- the wireless transceiver module 204 receives the signal strength of the signal. If the signal strength is within the specified signal strength range, the data transmitted by the in-vivo sensor transmitting device 30 through the first wireless transceiver module 304 is normally recorded. When the signal strength exceeds the specified signal strength range, an alarm signal is sent by the buzzer 209 and/or the status indicator 208 under the control of the microprocessor 201.
- the external detection recording device 20 further includes a temperature sensor 202, wherein the memory 205 pre-stores the pH calibration factory data of the in-vivo sensing device 30; wherein the temperature sensor 202 collects the current ambient temperature and transmits To the second microprocessor 201;
- the second wireless transceiver module 204 receives initial data from the in-vivo sensing transmitting device 30 and transmits the data to the second microprocessor 201.
- the initial data may be a voltage difference
- the second microprocessor 201 calibrates the initial data, performs temperature compensation during the calibration process, obtains current calibration data, and applies the current calibration data to a pre-stored pH in the memory 205.
- the factory data is calibrated for comparison. If they are the same, subsequent operations are performed. If they are different, the calibration signal is sent to the in-vivo sensor transmitting device 30 through the second wireless transceiver module 204. At this time, the wireless transmitting module 5 in the inductive transmitting device 30 receives the calibration alarm signal and transmits it to the first microprocessor 303.
- the first microprocessor 303 controls the working indicator 306 to issue a calibration alarm signal. .
- the second wireless transceiver module includes: a low noise amplifier LNA 2041, an automatic gain control AGC 2042, a mixer 2043, a local oscillator 2046, and an IF.
- the LNA 2041 can amplify the weak signal for post-stage pickup;
- the AGC 2042 can automatically adjust the gain of the LNA 39 by detecting the signal strength, and can receive an external wireless signal with a wider amplitude range;
- the frequency converter 2043 can mix the external high frequency signal and the locally generated frequency to generate an intermediate frequency signal with moderate frequency to facilitate demodulation of the subsequent stage data;
- the local oscillator 2046 is composed of a phase locked loop circuit, and the local crystal oscillator signal is used.
- an embodiment of the present invention further provides an esophageal pH wireless monitoring and positioning system, including: an in vivo sensing transmitting device 30 and an in vitro detecting and recording device 20;
- the in-vivo detection transmitting device 30 includes: a pH sensor 301, a sampling circuit 302, a first microprocessor 303, a power management 305, a first wireless transceiver module 304, and a first device 307, wherein the external detection recording device 20 includes a second microprocessor 201, a power management 210, a buzzer 209, a memory 205, a data interface 206, a button 207, a second wireless transceiver module 204; a status indicator 208, a housing 211, and a second device 203;
- the second device 203 in the in-vitro detection recording device 20 cooperates with the first device 307 in the in-vivo sensing transmitting device 30, and if the in-vivo detecting recording device 20 detects that the in-vivo sensing transmitting device 30 is within the specified range, then normal Recording data transmitted by the in-vivo sensing transmitting device 30 through the first wireless transceiver module 304, if the external detecting device 20 detects that the in-vivo sensing transmitting device 30 is out of the specified range, passes the buzzer under the control of the type processor 201. 209 and/or status indicator 208 signals an alarm;
- the in vitro detection and recording device 20 periodically collects the signal strength of the signal received by the second wireless transceiver module 204 under the control of the microprocessor 201. If the signal strength is within the specified signal strength range, the normal recording body is detected. The data transmitted by the sensor transmitting device 30 through the first wireless transceiver module 304 passes the buzzer 209 and/or status under the control of the second microprocessor 201 if the signal strength is detected to exceed the specified signal strength range. The indicator light 208 signals an alarm.
- the first device 307 of the in-vivo sensing device 30 is a permanent magnet; the second device 203 of the in-vivo detecting device 20 is a magnetic sensor; at this time, the second of the in-vivo detecting device 20
- the device 203 cooperates with the first device 307 in the in-vivo sensing device 30, and specifically includes: testing, by the magnetic sensor, the strength of the magnetic field generated by the permanent magnet in the in vivo sensing device 30, if the magnetic field strength is within a specified magnetic field strength range
- the in-vivo detection recording device 20 monitors that the in-vivo sensing transmitting device 30 is within a specified range; if the magnetic field strength exceeds the specified range, the in-vivo detecting and recording device 20 detects that the in-vivo sensing transmitting device 30 is out of the specified range.
- the reed switch is connected in series between the pH sensor 301 and the sampling circuit 302; then the second device 203 in the external detecting recording device 20 is The magnet is inductively controlled to open and close by the magnet; at this time, the second device 203 in the external detecting and recording device 20 cooperates with the first device 307 in the in-vivo sensing transmitting device 30, and specifically includes: if the magnet Within a predetermined distance from the reed switch, the reed switch closes to electrically connect the circuit between the pH sensor 301 and the sampling circuit 302 in the in-vivo sensing device 30.
- the external detecting and recording device 20 detects that the in-vivo sensing transmitting device 30 is within a specified range; if the magnet and the reed switch exceed a preset distance, the reed switch opens and closes the in-vivo sensing transmitting device In the circuit between the pH sensor 301 and the sampling circuit 302, the external detecting and recording device 20 monitors that the in-vivo sensing transmitting device 30 is out of the specified range.
- the external detecting and recording device 20 further includes a temperature sensor 202, wherein the memory 205 pre-stores the pH calibration factory data of the in-vivo sensing transmitting device 30; the temperature sensor 202 collects the current ambient temperature and transmits the current ambient temperature to The second wireless transceiver module 204 receives the initial data from the in-vivo sensing transmitting device 30 and transmits the data to the microprocessor 201, where the initial data may be a voltage difference;
- the second microprocessor 201 calibrates the initial data, performs temperature compensation during the calibration process, obtains current calibration data, and applies the current calibration data to a pre-stored pH in the memory 205.
- the factory data is calibrated for comparison. If they are the same, the subsequent operations are performed. If they are different, the calibration alarm signal is sent to the internal sensing transmitting device 30 through the second wireless transceiver module 204. Further, the data logger is in the second microprocessor 201. Under the control, the alarm signal can be sent through the buzzer 209 and/or the status indicator 208 at the same time;
- the in-vivo sensing device 30 further includes a work indicator 306;
- the wireless transmitting module 5 in the in-vivo sensing transmitting device 30 receives the calibration alarm signal and transmits it to the first microprocessor 303;
- the first microprocessor 303 controls the work indicator 306 to issue a calibration alarm signal. It can be seen that, by using the esophageal pH wireless monitoring and positioning system provided by the embodiment of the present invention, the in vivo sensing device esophagus 1 is realized by the cooperation of the first device 307 in the in vivo sensing transmitting device 30 and the second device 203 in the external detecting recording device 20. Real-time monitoring of the internal position; avoiding invalid detection caused by accidental shedding of the plastic capsule, and reducing the detection cost of the patient; detecting the received signal intensity by the in-vivo sensing transmitting device 30, avoiding the possibility of the patient at work or rest The resulting signal interruption problem ensures the integrity of the detected data. Furthermore, the accuracy of the test is improved by the calibration of the system before use and the temperature compensation during the calibration process.
- the in-vivo sensing transmitting device is a pH capsule
- the first device in the in-vivo sensing device is a permanent device.
- Magnet, in vitro detection and recording device is a data recorder, in vitro detection recording device
- the second device is a magnetic sensor, and the process includes:
- Step 501 the data logger is controlled by the second microprocessor 201 to periodically test the magnetic field strength generated by the permanent magnet 307 in the capsule by the magnetic sensor 203;
- Step 502 determining whether the magnetic field strength of the tested capsule changes beyond a specified range, and if so, executing step 503, otherwise performing step 504;
- Step 503 the data logger sends an alarm signal through the buzzer 209 and/or the status indicator 208 under the control of the second microprocessor 201 to indicate a positioning fault;
- Step 504 ending the process and performing other system tasks.
- Other tasks of the system refer to tasks other than the task, and the following are the same, and are not repeated.
- the in vivo sensing and transmitting device is a pH capsule
- the in vitro detecting and recording device is a data recorder.
- the process includes:
- Step 601 The data recorder periodically collects the signal strength of the signal received by the second wireless transceiver module 204 under the control of the second microprocessor 201.
- Step 602 it is determined whether the collected signal strength changes beyond the specified range, and if so, step 603 is performed, otherwise step 604 is performed;
- Step 603 the data logger sends an alarm signal through the buzzer 209 and/or the status indicator 208 under the control of the second microprocessor 201 to indicate a signal strength failure;
- Step 604 ending the process and performing other system tasks.
- the in vivo sensing and emitting device is a pH capsule
- the in vitro detecting and recording device is a data recorder.
- the process includes:
- Step 701 according to the received command to determine whether calibration is required, and if so, step 702 is performed, otherwise step 706 is performed;
- Step 702 the ambient temperature collected by the temperature sensor 202 during calibration
- Step 703 receiving initial data from the in-vivo sensing transmitting device 30, performing calibration on the initial data, and performing temperature compensation in the calibration process to obtain current calibration data;
- temperature compensation means that the collected ambient temperature value is processed by look-up table and software, and the temperature-calibrated pH-mV curve is compensated to minimize the influence of temperature on the test; Step 704, determining the validity of the current calibration data, specifically determining whether the current calibration data is consistent with the pre-stored pH calibration factory data, if yes, step 706 is performed, otherwise step 705 is performed;
- Step 705 sending a calibration alarm signal to the in-vivo sensing transmitting device 30; meanwhile, the data recorder sends an alarm signal through the buzzer 209 and/or the status indicator 208 under the control of the second microprocessor 201, for example, buzzing The device emits a 1 second chime to alert the operator;
- Step 706 ending the process and performing other system tasks.
- a calibration alarm signal is issued via the work indicator 306.
- the embodiment of the present invention further provides a wireless monitoring and positioning method for esophage pH, which includes:
- the in-vivo detection recording device 20 cooperates with the in-vivo sensing transmitting device 30 to determine whether the position of the in-vivo sensing transmitting device 30 is within a specified range, and if not, to issue an alarm signal;
- the in-vivo detection recording device 20 periodically collects the signal strength of the received signal to determine whether the signal strength is within a specified signal strength range. If so, the data transmitted by the in-vivo sensing transmitting device 30 is normally recorded; otherwise, an alarm signal is issued.
- the method further includes:
- the pH calibration factory data of the in vivo sensing transmitting device 30 is pre-stored in the in vitro detection recording device 20;
- the in vitro detection recording device 20 receives initial data from the in vivo sensing transmitting device 30, calibrates the initial data, and performs temperature compensation during the calibration process to obtain current calibration data, applying the current calibration
- the data is compared with pre-stored pH calibration factory data, and if different, a calibration alarm signal is sent to the in-vivo sensor transmitting device 30; further, the data recorder can pass the buzzer 209 under the control of the second microprocessor 201 and / or status indicator 208 sends an alarm signal;
- the in-vivo sensing transmitting device 30 After receiving the calibration alarm signal, the in-vivo sensing transmitting device 30 issues a calibration alarm signal.
- the esophageal pH wireless monitoring and positioning method realizes the position of the in vivo esophageal sensing device by the cooperation of the first device 307 in the in vivo sensing transmitting device 30 and the second device 203 in the external detecting recording device 20 Real-time monitoring; avoids invalid detection caused by accidental shedding of the capsule, and reduces the detection cost of the patient; the detection of the received signal intensity by the in-vivo sensing transmitting device 30 avoids the possibility that the patient may be caused during work or rest The signal is interrupted, thus ensuring the integrity of the detected data. Furthermore, the accuracy of the test is improved by the system's pre-use calibration and temperature compensation during calibration.
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Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2012116467/14A RU2522970C2 (ru) | 2009-10-16 | 2010-10-15 | Следящая система, аппаратура и способ позиционирования для беспроводного мониторинга уровня ph в пищеводе |
CA2777811A CA2777811C (en) | 2009-10-16 | 2010-10-15 | Positioning system, apparatus, and method for wireless monitoring of esophageal ph value |
KR1020127012487A KR101378751B1 (ko) | 2009-10-16 | 2010-10-15 | Ph 값 무선 모니터링을 위한 포지셔닝 시스템, 장치 및 방법 |
EP10822990.7A EP2489303B1 (en) | 2009-10-16 | 2010-10-15 | Positioning system and method for esophageal ph value wireless monitoring |
PL10822990T PL2489303T3 (pl) | 2009-10-16 | 2010-10-15 | System pozycjonowania i sposób bezprzewodowego monitorowania wartości pH przełyku |
AU2010306359A AU2010306359B2 (en) | 2009-10-16 | 2010-10-15 | Positioning system, apparatus and method for esophageal PH value wireless monitoring |
JP2012533457A JP5739435B2 (ja) | 2009-10-16 | 2010-10-15 | 食道pH値無線監視のための位置決めシステム、装置及び方法 |
ES10822990.7T ES2668223T3 (es) | 2009-10-16 | 2010-10-15 | Sistema de posicionamiento y método para monitorización inalámbrica del valor del pH esofágico |
US13/447,322 US20120203084A1 (en) | 2009-10-16 | 2012-04-16 | POSITIONING SYSTEM, APPARATUS, AND METHOD FOR WIRELESS MONITORING OF ESOPHAGEAL pH VALUE |
Applications Claiming Priority (2)
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CN2009101911951A CN101711673B (zh) | 2009-10-16 | 2009-10-16 | 食道酸碱度无线监测定位系统、装置及方法 |
CN200910191195.1 | 2009-10-16 |
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US13/447,322 Continuation-In-Part US20120203084A1 (en) | 2009-10-16 | 2012-04-16 | POSITIONING SYSTEM, APPARATUS, AND METHOD FOR WIRELESS MONITORING OF ESOPHAGEAL pH VALUE |
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PCT/CN2010/001623 WO2011044758A1 (zh) | 2009-10-16 | 2010-10-15 | 食道酸碱度无线监测定位系统、装置及方法 |
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US (1) | US20120203084A1 (zh) |
EP (1) | EP2489303B1 (zh) |
JP (1) | JP5739435B2 (zh) |
KR (1) | KR101378751B1 (zh) |
CN (1) | CN101711673B (zh) |
AU (1) | AU2010306359B2 (zh) |
CA (1) | CA2777811C (zh) |
ES (1) | ES2668223T3 (zh) |
HU (1) | HUE037789T2 (zh) |
PL (1) | PL2489303T3 (zh) |
PT (1) | PT2489303T (zh) |
RU (1) | RU2522970C2 (zh) |
WO (1) | WO2011044758A1 (zh) |
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CN101711673B (zh) * | 2009-10-16 | 2012-11-21 | 重庆金山科技(集团)有限公司 | 食道酸碱度无线监测定位系统、装置及方法 |
GB2476466A (en) * | 2009-12-22 | 2011-06-29 | Ritelite Systems Ltd | Battery monitor for light. |
CN102670158A (zh) * | 2012-05-10 | 2012-09-19 | 无锡市华焯光电科技有限公司 | 一种可定位胶囊内窥镜系统 |
GB201210439D0 (en) * | 2012-06-13 | 2012-07-25 | Softcell Medicals | Apparatus |
JP6854588B2 (ja) * | 2012-08-29 | 2021-04-07 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 高度な生命維持デバイスのための環境及び使用監視システム |
GB201304738D0 (en) | 2013-03-15 | 2013-05-01 | Mars Inc | Sampling Device |
AU2015316581B2 (en) * | 2014-09-17 | 2020-06-11 | Mars, Incorporated | Device |
WO2016042300A1 (en) * | 2014-09-17 | 2016-03-24 | Mars, Incorporated | Device |
WO2016042301A1 (en) * | 2014-09-17 | 2016-03-24 | Mars, Incorporated | Device |
CN104706307A (zh) * | 2015-03-23 | 2015-06-17 | 朱玉森 | 一种消化道无介入式诊查系统 |
CN105342543B (zh) * | 2015-09-25 | 2017-06-09 | 重庆金山科技(集团)有限公司 | 食道多参数无线检测胶囊及检测控制系统 |
CN107625515A (zh) * | 2017-10-10 | 2018-01-26 | 重庆金山医疗器械有限公司 | 食道pH导管恒温校准装置 |
CN111494186B (zh) * | 2020-06-01 | 2024-01-02 | 上海安翰医疗技术有限公司 | 振动胶囊及其检测方法 |
US20220047180A1 (en) * | 2020-08-13 | 2022-02-17 | The Chinese University Of Hong Kong | Apparatus and methods for monitoring concentrations of analytes in body fluid |
CN112472008A (zh) * | 2020-11-02 | 2021-03-12 | 重庆金山医疗器械有限公司 | 一种ph胶囊定位装置、方法、设备及可读存储介质 |
CN116448867B (zh) * | 2023-06-16 | 2023-10-20 | 北京市农林科学院智能装备技术研究中心 | 一种瘤胃液酸碱度无线无源传感器及监测系统 |
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- 2010-10-15 PT PT108229907T patent/PT2489303T/pt unknown
- 2010-10-15 JP JP2012533457A patent/JP5739435B2/ja not_active Expired - Fee Related
- 2010-10-15 PL PL10822990T patent/PL2489303T3/pl unknown
- 2010-10-15 EP EP10822990.7A patent/EP2489303B1/en active Active
- 2010-10-15 HU HUE10822990A patent/HUE037789T2/hu unknown
- 2010-10-15 RU RU2012116467/14A patent/RU2522970C2/ru active
- 2010-10-15 WO PCT/CN2010/001623 patent/WO2011044758A1/zh active Application Filing
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Also Published As
Publication number | Publication date |
---|---|
PT2489303T (pt) | 2018-06-28 |
EP2489303A1 (en) | 2012-08-22 |
RU2012116467A (ru) | 2013-11-27 |
KR20120112399A (ko) | 2012-10-11 |
HUE037789T2 (hu) | 2018-09-28 |
CN101711673B (zh) | 2012-11-21 |
US20120203084A1 (en) | 2012-08-09 |
PL2489303T3 (pl) | 2018-10-31 |
JP5739435B2 (ja) | 2015-06-24 |
RU2522970C2 (ru) | 2014-07-20 |
AU2010306359B2 (en) | 2014-01-16 |
EP2489303A4 (en) | 2017-02-22 |
ES2668223T3 (es) | 2018-05-17 |
KR101378751B1 (ko) | 2014-04-04 |
EP2489303B1 (en) | 2018-03-28 |
CA2777811C (en) | 2017-06-13 |
CN101711673A (zh) | 2010-05-26 |
JP2013507203A (ja) | 2013-03-04 |
AU2010306359A1 (en) | 2012-05-10 |
CA2777811A1 (en) | 2011-04-21 |
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