WO2011040697A1

WO2011040697A1 - Food composition containing concentrate of theanine and oat extract for promoting memory, learning ability and psychological stability

Info

Publication number: WO2011040697A1
Application number: PCT/KR2010/004001
Authority: WO
Inventors: 유세진; 라찬수; 오유진; 정진오; 이상준
Original assignee: (주)아모레퍼시픽
Priority date: 2009-10-01
Filing date: 2010-06-21
Publication date: 2011-04-07
Also published as: KR101692874B1; KR20110036329A

Abstract

The present invention relates to a food composition for promoting concentration, memory, mental stability and learning, and more particularly, to a food composition containing high concentrations of theanine and oat extract which increase brain, alpha-wave levels that counter beta-waves which are generated during stressful situations, thereby enhancing high concentration, memory, psychological stability and effective learning.

Description

Food composition for improving concentration, memory, psychological stability and learning ability containing deanine and oat extract

The present invention relates to a food composition that enhances concentration, memory, psychological stability, and learning ability, and more specifically, contains ananine and oat extracts to increase high alpha waves generated during concentration and stress The present invention relates to a food composition that helps to effectively learn by reducing the high beta wave generated during development to enhance concentration, memory and psychological stability.

Modern society demands constant learning as a competitive society, and this learning is an essential requirement not only for students but also for society. However, as a person ages, brain function decreases and concentration decreases, and memory function decreases or concentration decreases due to external factors such as stress.

On the other hand, stress such as strong external oppression, resulting in obsessive compulsiveness, depression is also a major obstacle for a person to concentrate. Stress is emerging as an important health problem in modern people, and it is reported that more than one third of adults over 20 years of age are under stress, and environmental factors (weather, transportation), social factors (occupation, marriage, parenting) In the case of students, the factors such as tests are closely related to our lives. Stress varies in intensity depending on the individual's personality, hobbies, resolution, surroundings, and control, but most of them involve depression and reduce concentration. Therefore, it is urgent to find a substance that relieves stress and enhances concentration while activating brain function.

Accordingly, the present inventors have studied to find a composition that has no side effects on the human body and has an effect of increasing concentration and memory, and the result shows that the combination of deanine and oat extract has an excellent effect of improving concentration, memory, psychological stability, and learning ability. Discovered and completed the present invention.

Accordingly, it is an object of the present invention to provide a food composition that can improve learning ability by increasing concentration and memory and psychological stability.

In order to achieve the above object, the present invention provides a food composition containing deanine and oat extract to improve concentration, memory, psychological stability and learning ability.

The food composition for improving concentration, memory, psychological stability and learning ability according to the present invention not only increased the total amount of alpha waves when measuring EEG after ingestion, but also increased the ratio of high alpha waves generated at high concentrations, and stress. The ratio of high beta waves used as an index of was decreased. In addition, the success rate after drinking the drink significantly increased in the experiment to find the omitted number from 1 to 9 before and after ingestion. In addition, in the evaluation of weekly cognitive efficacy, the head clearness and concentration improvement items were significantly improved when ingested together compared to ingesting deanine or oat extract alone.

Therefore, the food composition of the present invention, examinees, distracted children, distracted children, and adults unable to concentrate on work due to stress when drinking, psychologically stable and increase the brain activity to improve concentration and memory and improve learning ability I can let you.

1 is a graph comparing the change of the ratio (al / hb) of alpha wave and high beta wave in the Fz region according to the ingested sample.

Figure 2 is a graph comparing the change in the ratio (al / hb) of alpha wave and high beta wave in the Oz region according to the ingested sample.

3 is a graph comparing the change of the alpha wave peak in the Fz region according to the ingested sample.

4 is a graph comparing the change of the alpha wave peak in the Oz region according to the ingested sample.

5 is a graph comparing the success rate of problem solving according to the intake sample.

6 is a graph comparing the evaluation of the subjective cognitive effect according to the ingested sample.

The present invention provides a food composition for improving concentration, memory, psychological stability and learning ability containing deanine and oat extract.

Hereinafter, the present invention will be described in more detail.

Theanine used as an active ingredient in the present invention is a compound represented by the following Chemical Formula 1 and is a major amino acid of green tea.

Formula 1

Looking at the research on the efficacy of deanine, the most representative mechanisms of anti-cancer efficacy, effects on the effects of the nervous system and stress inhibitory effects are known. For example, it suppresses caffeine-induced excitability, increases alpha-waves in the brain to relieve tension, antistress effects such as suppressing stress-induced heart rate increases and reducing stress response factors, and cranial nerve protection. It also has some anti-oxidant effects such as anti-oxidant effect, immune boosting effect, lowering blood pressure, and oxidation of low-density lipid protein cholesterol (LDL-cholesterol).

In the human brain, there is a barricade that prevents the intake of nutritional or other ingredients from the food that the human body consumes. This is called the 'Blood Brain Barrier' (BBB). Once a specific component passes through the brain gate, it is delivered to brain cells through the bloodstream and directly affects the nerve function. The deanine of the present invention passes directly through these brain gates to the brain cells and directly affects the brain cells. give.

Deanine, the active ingredient of the present invention, is preferably ingested in an amount of 50 to 2000 mg in a single drink of the composition. This is because if the effect is less than 50mg, the increase of the effect is not large compared to the increase of intake if it exceeds 2000mg rather inefficient.

In addition, oat (Oat) used as an active ingredient in the present invention is estimated to have spread from eastern to central Europe with barley around 5000 BC, and is a plant that has been used for more than 800 years for nutritional and medical purposes in Europe. Oat is a monocotyledonous plant of the rice family Paddy, and it is an cultivated crop of two years. It is also called oat. There are about 70 species, but only a few of them are grown, mainly Wild oat (avena sativa L.). The height is about 90㎝, the leaves are 15 ~ 30㎝ long, the butterfly 6 ~ 12㎜, the leaf is flat, the leaf is long and the leaf lobe is short and finely divided. Flowers bloom in May-June, cone inflorescences, and branches turn and split again. A glume has no ridges, many veins, and flanks. The fruit is wrapped inside and outside, with hairs and grooves on one side. Fruits are made from oatmeal and are used as alcohol, sweets and livestock feed.

Oats act as a potential neuroprotective agent by inhibiting Monoamine Oxidase B (MAO-B), and by inhibiting Phosphodiesterase 4 (PDE 4) to improve mood and cognition. It has been used as a supplement for nerve sedation, diuresis, cognitive stimulation and analgesic detoxification.

Oat extracts of the present invention can be prepared according to conventional methods known in the art, i.e. using conventional solvents under conditions of conventional temperature and pressure. It is preferably extracted at room temperature with an extraction solvent selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1,3-butylene glycol, followed by filtration and concentration under reduced pressure. Can be prepared.

Oat extract is an active ingredient of the present invention is preferably ingested in an amount of 4 to 800mg when drinking the composition once. This is because if the effect is less than 4mg, the increase of the effect is not very large compared to the increase intake if more than 800mg rather inefficient.

The complex of the deanine and oat extract of the present invention is characterized by improving psychological stability and ultimately improving learning ability by increasing concentration and memory.

The food composition of the present invention is applicable to food of various formulations including oral food compositions such as beverages, pills, granules, tablets or capsules.

In the present invention, the success rate of EEG analysis and problem solving was measured for objective identification of concentration, memory, psychological stability, and learning ability, and mood changes before and after the experimenter's intake were compared through a questionnaire.

Hereinafter, the present invention will be described in more detail through experimental and formulation examples, but the scope of the present invention is not limited thereto.

Preparation Example Preparation of Composition Containing Deanine and Oat Extract

The composition containing the deanine and oat extract according to the composition of Table 1 was prepared by simply mixing each component. Deanine was used as Suntheanine by Sun Chemical Co., Ltd., and EFLA 955 Wild Green Oat Neuravena by Frutarom was used as oat extract.

Table 1

Sample name	Deanine (mg)	Oat Extract (mg)
A	50	0
B	0	4
C	50	4
D	100	8

[Experimental Example 1] Evaluation of the improvement effect of concentration, memory and psychological stability

In order to evaluate the effect of improving the concentration, memory and psychological stability of the complex of the deanine and oat extracts, EEG analysis was performed using the composition prepared above. The specific method is as follows.

Twelve men and women in their 10s and 30s who were physically healthy and who are not currently taking drugs were selected for the survey. Do not exercise or drink excessively on the day before the experiment.

In order to minimize the influence of the external environment on the experimenter, the internal temperature and humidity were kept constant before and after the measurement, and the mind was rested in the waiting area for 30 minutes before the measurement. EEG was measured (including problem solving) before taking the test sample. Thereafter, the four compositions were completely dissolved in 100 ml of 18 ° C. water to be consumed. Ingestion was performed within 5 minutes and waited for 30 minutes in a stable atmosphere so that there was no additional stimulus at the time of ingestion, and then EEG after drinking (including problem solving) and cognitive changes were measured.

There is a physiologically generated electrical waveform in the brain, commonly referred to as brain waves. There are four kinds of human brain waves: alpha wave (α), beta wave (β), theta wave (θ), and delta wave (δ). Normally, the brain waves that occur when a person opens their eyes are beta waves (12-23 Hz), which indicates that the brain responds to extraterrestrial activity in a tense state, and 23-38 Hz is a high-beta wave ( high β) is used as a stress index in the brain. Alpha waves (8-12Hz) increase with eyes closed, and alpha waves are known to be associated with memory, concentration and creativity. High alpha waves are unified in the state of mind and appear at maximum levels of memory and concentration. Theta waves (4-7 Hz) occur during sleepy or shallow sleep, while delta waves (0.5-4 Hz) occur during deep sleep. Therefore, by measuring the change in brain waves and use it as a physiological index of the brain can determine the state of the brain.

In the EEG measurement method, EEG is divided into Fz area (area for thinking and processing input information through exchange with its stored information) and Oz area (area for intuitive input and processing of information) for 5 minutes and eye opening for 5 minutes. Alpha wave, high alpha wave, beta wave and high beta wave were measured at the same time in order of 10 minutes in the lung, 5 minutes in the problem, 5 minutes in the lung, and the values according to the change were quantified. Subsequently, electroencephalogram changes after ingestion were analyzed with the brainwave value before ingestion as the default. We measured the peaks of alpha waves (al pk) and the ratios of alpha and high beta waves (al / hb), which are known to increase during concentration, and the mean and standard deviation for each EEG change. Statistical analysis was verified by t-test using MINITAB. The results are shown in Figures 1-4, where the bars represent the range of data coming in at the 95% confidence level and the middle line represents the mean of the data.

As can be seen in Figure 1, when the deanin only ingested the ratio of al / hb slightly increased due to the increase of the alpha wave in the Fz region, only one oat extract, the change of al / hb does not change significantly before and after intake Did. On the other hand, in the experimental group ingested with deanine and oat extract, the value of al / hb increased significantly. Thus, when the deanine and oat extract of the present invention are ingested together, the Fz brain region responsible for thinking ability is activated, thereby improving concentration and reducing stress in a situation where stress such as learning or problem solving.

As can be seen in Figure 2, changes in the EEG in the Oz region was similar to the brain activity pattern in the Fz region showed a significant increase in al / hb in the experimental group ingested with deanine and oat extract. Therefore, the brain was also activated in the Oz region that receives intuitive information when the deanine and oat extract of the present invention are ingested together.

3 to 4 show peaks of alpha waves (al pk) in the Fz region and the Oz region. Alpha wave is a brain wave generated at 8 ~ 12Hz, the stronger the cognitive brain activity, the higher the frequency of the brain wave can be used as an indicator for measuring brain activity.

As can be seen in Figure 3, the frequency of the alpha wave in the Fz region slightly increased in the experimental group ingested only deanine, there was no change in the experimental group ingested only oat extract. On the other hand, the average alpha wave frequency of the experimental group fed with deanine and oat extract increased by 23.75% and 32.5%, respectively.

As can be seen in Figure 4, the peak change of the alpha wave in the Oz region was slightly less than the change in the Fz region, the average alpha wave frequency of the experimental group ingested with deanine and oat extract was 7.5% and 11.5 before and after ingestion, respectively. It was increased by%, which was an improvement over the experimental group ingested the deanine or oat extract alone.

Therefore, when the deanine and oat extracts of the present invention are ingested together, the frequency of the peaks of the alpha waves in the Fz region and the Oz region were both increased, and the cognitive brain activity was confirmed to be stronger.

Based on the above four EEG analyzes, taking deanine and oat extract together showed higher EEG change compared to the case of ingesting deanine and oat extract alone. Prove that there is synergistic effect of oat extract.

Experimental Example 2 Problem Solving Success Rate

In order to check the success rate of the problem solution of the composition obtained in Preparation Example 1, each of 12 men and women in their 10s to 30s to be investigated, one of the numbers from 1 to 9 for 1 second on the screen to show only one missing The experiment was conducted by setting the number within 3 seconds. This problem solving is a form that confirms the instantaneous information recognition speed and the speed of accident processing of information received from the outside world, and solved a total of 20 problems to compare the success rate before and after the drink intake and analyzed the change. The results are shown in FIG.

As can be seen in Figure 5, the experimental group intake of the deanin or oat extract alone increased the success rate of the problem pool after ingestion slightly, in the experimental group ingested the deanin and oat extract together, the success rate of the problem pool was 30% before and after each intake, 32.5% incremental improvement. Therefore, it was found that the deanine and oat extracts of the present invention exhibit a strong synergistic effect, effectively increasing the recognition speed and accuracy of problem thinking.

Experimental Example 3 Subjective Cognitive Effect Evaluation

In order to evaluate the subjective cognitive effects of the composition obtained in Preparation Example 1, an experiment was conducted with 12 men and women each in their 10s and 30s. Subjective cognitive effect assessment was assessed on a 9-point scale through questions of cognitive changes before and after ingestion. When no change was made as 0 points and 9 was recognized when certain functionality was recognized. Five questions were asked about improvement of memory, psychological stability, head clearness, stress relief and concentration improvement. The results are shown in FIG. 6.

As can be seen in Figure 6, the improvement of memory in the cognitive effect did not show a significant difference, the psychological stability obtained an excellent score of 6.0 or more on average only in A, C and D containing the dean component. The degree of hair clarity was much improved in C and D containing the deanine and oat extracts, and was particularly excellent at 5.3 in the high content of deanine and oat extracts. The evaluation of stress relief showed a similar pattern to the psychological stability evaluation, and the improvement in concentration was found to be significantly improved in the experimental group in which deanine and oat extract were combined.

Thus, when the deanine and oat extracts of the present invention are ingested together, they showed excellent cognitive effects in terms of memory improvement, psychological stability, head clearness, stress relief and concentration improvement, and in particular, head clearness and concentration power. The improvement showed high satisfaction.

Hereinafter, the formulation examples of the composition will be described, but the present invention is not limited thereto.

Formulation Example 1

Food composition for improving concentration, memory, psychological stability and learning ability was prepared in the composition of Table 2 below.

TABLE 2

division	Raw material name	Content (% by weight)
One	Deanine	2.5
2	oat	0.2
3	Mate	0.2
4	Guarana	0.2
5	Green Tea Extract	0.2
6	Pomegranate Powder	33.5
7	Blueberry Powder	14.5
8	Dietary Fiber	23.55
9	Enzyme Treatment Stevia	9.75
10	Citric acid	6.5
11	Malic acid	1.5
12	Palatine	0.9
13	Refined Salt	0.5
14	Guar gum	0.5
15	Berry flavor	5.5

Formulation Example 2

Food composition for improving concentration, memory, psychological stability and learning ability was prepared in the composition of Table 3 below.

TABLE 3

division	Raw material name	Content (% by weight)
One	Deanine	2.5
2	oat	0.2
3	Mate	0.2
4	Guarana	0.15
5	Green Tea Extract	0.15
6	Lemon powder flavor	0.75
7	Ginger powder flavor	0.75
8	Dietary Fiber	1.98
9	Enzyme Treatment Stevia	10.5
10	Citric acid	8.0
11	Palatine	1.9
12	Refined Salt	0.5
13	Guar gum	0.75
14	Vitamin B2	0.02
15	Lemon Ginger Powder	35.8
16	Lemon powder	35.85

Claims

Food composition containing deanine and oat extract as an active ingredient.
The food composition according to claim 1, wherein the deanine is ingested in an amount of 50 to 2000 mg in a single drink of the composition.
The food composition according to claim 1, wherein the oat extract is ingested in an amount of 4 to 800 mg in a single drink of the composition.
The food composition of claim 1, wherein the composition enhances concentration.
The food composition of claim 1, wherein said composition promotes psychological stability.
The food composition of claim 1, wherein the composition enhances learning ability.
The food composition of claim 1, wherein said composition enhances memory.
8. A food composition according to any one of the preceding claims, wherein said composition is prepared in the form of at least one oral food composition selected from the group consisting of beverages, pills, granules, tablets and capsules.