KR101692874B1 - Food composition for improving concentration, memory, psychological stability and learning ability containing Theanine and extract of Oat - Google Patents
Food composition for improving concentration, memory, psychological stability and learning ability containing Theanine and extract of Oat Download PDFInfo
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- KR101692874B1 KR101692874B1 KR1020090093931A KR20090093931A KR101692874B1 KR 101692874 B1 KR101692874 B1 KR 101692874B1 KR 1020090093931 A KR1020090093931 A KR 1020090093931A KR 20090093931 A KR20090093931 A KR 20090093931A KR 101692874 B1 KR101692874 B1 KR 101692874B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Abstract
본 발명은 집중력, 기억력, 심리적 안정 및 학습 능력을 증진시키는 식품 조성물에 관한 것으로, 보다 상세하게는 데아닌(Theanine) 및 귀리(Oat) 추출물을 함유하여 집중시 발생하는 하이 알파파를 증가시키고 스트레스 발생시 생성되는 하이 베타파를 감소시킴으로써 집중력, 기억력 및 심리적 안정을 증진시켜 효과적인 학습이 가능하도록 도와주는 식품 조성물에 관한 것이다.The present invention relates to a food composition for enhancing concentration, memory, psychological stability and learning ability. More particularly, the present invention relates to a composition containing theanine and oat extracts to increase hyaluronan during concentration, The present invention relates to a food composition which improves concentration, memory, and psychological stability by reducing the high-beta wave generated at the time of occurrence, thereby enabling effective learning.
데아닌, 귀리, 하이알파파 증가, 하이베타파 감소, 집중력 향상, 기억력 증진, 심리적 안정 증진, 학습 능력 향상Increase of deni, oat, hyaluronic acid, decrease of high beta wave, improvement of concentration, improvement of memory, improvement of psychological stability, improvement of learning ability
Description
본 발명은 집중력, 기억력, 심리적 안정 및 학습 능력을 증진시키는 식품 조성물에 관한 것으로, 보다 상세하게는 데아닌(Theanine) 및 귀리(Oat) 추출물을 함유하여 집중시 발생하는 하이 알파파를 증가시키고 스트레스 발생시 생성되는 하이 베타파를 감소시킴으로써 집중력, 기억력 및 심리적 안정을 증진시켜 효과적인 학습이 가능하도록 도와주는 식품 조성물에 관한 것이다.The present invention relates to a food composition for enhancing concentration, memory, psychological stability and learning ability. More particularly, the present invention relates to a composition containing theanine and oat extracts to increase hyaluronan during concentration, The present invention relates to a food composition which improves concentration, memory, and psychological stability by reducing the high-beta wave generated at the time of occurrence, thereby enabling effective learning.
현대 사회는 경쟁을 추구하는 사회로써 끊임없는 학습을 요구하고 있으며, 이러한 학습은 학생들뿐 아니라 사회인에게도 필수적인 요구 사항이다. 그런데 사람은 나이가 들어갈수록 뇌기능이 저하되고 집중력이 약화되며, 스트레스 등의 외적 요인에 의하여도 기억 기능이 감퇴되거나 집중력이 저하된다.Contemporary society is a competition society and requires continuous learning. This learning is an indispensable requirement not only for students but also for society. However, as the person gets older, the brain function decreases, the concentration is weakened, and the external function such as stress causes the memory function to decline or the concentration to decrease.
한편, 강한 외부 억압 등의 스트레스 및 이로 인한 강박증, 우울증도 사람이 집중력을 발휘하는데 큰 장애가 된다. 현대인에 있어서 스트레스는 중요한 건강상의 문제로 대두되고 있으며, 우리나라 20세 이상의 성인의 1/3이상이 스트레스를 받고 있다는 보고가 있으며 주변환경적 요인(날씨, 교통), 사회적 요인(직업, 결혼, 육아 등), 학생들의 경우 시험 등 그 요인들은 우리 생활과 아주 밀접한 관련을 맺고 있다. 스트레스는 개인의 성격, 취미, 해소법, 주변환경, 통제능력 등에 따라 그 강도가 다르나, 대부분 우울증을 수반하고 집중력을 저하시킨다. 따라서, 뇌기능을 활성화시키면서 스트레스를 완화시키고 집중력을 강화시키는 물질의 발견이 시급하다.On the other hand, stress such as strong external repression and the resulting obsessive-compulsive disorder and depression are also great impediments for people to concentrate. Stress is an important health problem in modern people and more than one third of adults over 20 years of age are reported to be stressed, and environmental factors (weather, traffic) and social factors (occupation, marriage, childcare Etc.), and the factors such as examinations for students are very closely related to our lives. Stress varies according to personality, hobbies, resolution, surrounding environment, and ability to control, but most of them are depressed and depressed. Therefore, it is imperative to find a substance that activates brain function while relieving stress and enhancing concentration.
이에, 본 발명자들은 인체에 부작용이 없고 집중력과 기억력을 증가시키는 효과가 있는 조성물을 찾고자 연구한 결과, 데아닌과 귀리 추출물의 복합물이 집중력, 기억력, 심리적 안정 및 학습 능력을 증진시키는 효과가 우수함을 발견하고 본 발명을 완성하였다.Accordingly, the inventors of the present invention found that a combination of denier and oat extract has excellent effects of enhancing concentration, memory, psychological stability, and learning ability as a result of searching for a composition which has no side effects on the human body and has an effect of increasing concentration and memory And completed the present invention.
따라서, 본 발명의 목적은 집중력과 기억력을 높이고 심리적으로 안정시킴으로써 학습 능력을 향상시킬 수 있는 식품 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide a food composition capable of improving learning ability by enhancing concentration and memory and psychologically stabilizing.
상기 목적을 달성하기 위하여, 본 발명에서는 데아닌 및 귀리추출물을 함유하여 집중력, 기억력, 심리적 안정 및 학습 능력을 증진시키는 식품 조성물을 제공한다.In order to achieve the above object, the present invention provides a food composition containing denier and oat extract to improve concentration, memory, psychological stability and learning ability.
본 발명에 의한 집중력, 기억력, 심리적 안정 및 학습 능력 증진용 식품 조성물은 섭취 후 뇌파 측정시 알파파의 전체적인 양이 증가했을 뿐 아니라, 고도의 집중시 발생하는 하이 알파파의 비율이 증가하였으며, 스트레스의 지수로 사용되는 하이 베타파의 비율은 감소하는 효과를 나타내었다. 또한, 섭취 전후 1~9까지의 숫자 중 생략된 숫자를 찾는 실험에서 음료 섭취 후의 성공률이 유의적으로 증가하였다. 또한, 주간적 인지 효능에 대한 평가에서 머리의 맑음 정도와 집중력 향상 항목이 데아닌 또는 귀리 추출물을 단독으로 섭취하는 것에 비하여 함께 섭취할 때 크게 향상되었다.The food composition for improving concentration, memory, psychological stability and learning ability according to the present invention not only increased the total amount of ALPHA in the measurement of brain waves after ingestion but also increased the proportion of ALA occurring at the time of high concentration, The ratio of the high beta wave used as an index of the effect was decreased. In addition, the success rate after beverage ingestion was significantly increased in the experiment to find the omitted number among the
따라서, 본 발명의 식품 조성물은 수험생, 집중을 못하고 산만한 어린이들, 및 스트레스로 업무에 집중하지 못하는 성인들이 음용시, 심리적으로 안정시키고 뇌의 활성을 높여 집중력과 기억력을 향상시키며 학습 능력을 향상시켜줄 수 있다.Accordingly, the food composition of the present invention improves concentration, memory, and learning ability by psychologically stabilizing the examinees, children who are not concentrated and distracted, and adults who can not concentrate on work due to stress, You can.
본 발명은 데아닌 및 귀리추출물을 함유하는 집중력, 기억력, 심리적 안정 및 학습 능력 증진용 식품 조성물을 제공한다.The present invention provides a food composition for enhancing concentration, memory, psychological stability and learning ability containing denier and oat extract.
이하, 본 발명을 더욱 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명에서 유효성분으로 사용되는 데아닌(Theanine)은 하기 화학식 1로 표현되는 화합물로써 녹차의 주요 아미노산이다.Theanine used as an active ingredient in the present invention is a compound represented by the following formula (1), which is a major amino acid of green tea.
데아닌의 효능에 대한 연구를 살펴보면, 가장 대표적으로는 항암 효능 기전, 신경계의 영향에 대한 효능 및 스트레스 억제 효능 등이 알려져 있다. 예를 들면, 카페인으로 인한 흥분 작용을 억제하고, 뇌에서 알파파(alpha-waves)가 증가하여 긴장을 완화시키며, 스트레스로 인한 심장 박동수 증가 억제 및 스트레스 반응 인자 감소와 같은 항스트레스 작용, 뇌신경 보호 효과, 면역력 증진 효과, 혈압 강 하, 저밀도 지질 단백질 콜레스테롤(LDL-cholesterol)의 산화를 억제시키는 항산화 효능도 일부 가지고 있으며, 최근에는 항 비만 작용 및 알코올 분해 효소 증가와 같은 생리 활성에 대해서도 연구되고 있다.Among the studies on the efficacy of denier, most notably, anticancer efficacy, efficacy against the effects of the nervous system, and stress-relieving efficacy are known. For example, it inhibits caffeine-induced excitement, increases alpha-waves in the brain to relieve tension, suppresses increased heart rate due to stress and reduces stress factors, cranial nerve protection (Antioxidant activity), antioxidant activity that suppresses the oxidation of LDL-cholesterol, and recently, bioactivity such as an anti-obesity effect and an increase in alcohololytic enzyme have been studied .
사람의 뇌에는 인체가 섭취한 음식 속 영양 성분이나 그 밖의 성분들이 들어오는 것을 막는 '바리케이트'가 있는데, 이것을 '뇌 관문(Blood Brain Barrier, BBB)'이라 한다. 일단 특정 성분이 뇌 관문을 통과하면 혈류를 통해 뇌 세포에 전달돼 신경작용에 직접 영향을 미치는데, 본 발명의 데아닌은 이러한 뇌 관문을 통과해서 직접 뇌세포로 전달되어 뇌세포에 직접적인 영향을 준다.There is a 'barricade' in the human brain that prevents the nutrients and other ingredients from entering the food that the human body ingests. This is called the 'Blood Brain Barrier' (BBB). Once a specific component passes through the brain portal, it is transmitted to the brain cells through the bloodstream and directly affects the nerve action. The present invention provides a direct effect of the present invention on the brain cells through such a brain portal, give.
본 발명의 유효성분인 데아닌은 조성물의 1회 음용시 50 내지 2000mg의 양으로 섭취되는 것이 바람직하다. 이는 50mg미만이면 그 효과가 미미하고, 2000mg을 초과하면 섭취량 증가에 비해 효과의 증가가 크지 않아서 오히려 비효율적이기 때문이다.It is preferable that the denien, which is the active ingredient of the present invention, is ingested in an amount of 50 to 2000 mg per one time of drinking the composition. This is because the effect is insignificant when the dose is less than 50 mg, and is ineffective if the dose exceeds 2000 mg because the increase in the effect is not large compared with the increase of the dose.
또한, 본 발명에서 유효성분으로 사용되는 귀리(Oat)는 기원전 5000년경 보리와 함께 동부에서 중유럽으로 퍼진 것으로 추정되고 있으며, 유럽에서 영양학적, 의학적 목적으로 800년 이상 사용되고 있는 식물이다. 귀리는 벼목 벼과의 외떡잎식물으로 두해살이 식용 재배작물이며 연맥(燕麥)이라고도 하며, 약 70여종이 있으나, 그 중 소수만 재배되고 있으며, 주로 Wild oat(avena sativa L.)종이 재배되고 있다. 높이는 90㎝ 정도, 잎은 길이 15~30㎝, 나비 6~12㎜이고 편평하고 엽초가 길며 엽설(葉舌)은 짧고 잘게 갈라진다. 꽃은 5∼6월에 피며 원추(圓錐) 꽃차례이고, 가지는 돌려나며 다시 갈라진다. 포영(苞穎)은 능선(稜線)이 없으며 맥(脈)이 많고 양쪽으로 벌어진다. 영과(穎果)는 내외영(內外穎)으로 싸이고 털이 있으며 한쪽에 홈이 파진다. 열매는 오트밀로 만들어 먹으며 알코올·과자의 원료 및 가축의 사료로 쓰이고 있다. The oat used as an active ingredient in the present invention is estimated to have spread from eastern to central Europe with barley about 5000 BC and has been used for more than 800 years in Europe for nutritional and medical purposes. Oat is a monocotyledonous plant of the rice blossom germ, and it is a biennial edible cultivated crop. It is also known as 丸 麦, and there are about 70 species, of which only a few are cultivated, mainly Wild oat (avena sativa L.). Height is about 90㎝, leaf length is 15 ~ 30㎝, butterfly is 6 ~ 12㎜, flat, leaf sheath is long, leaf tongue is short and fine cracks. The flower blooms in May-June, it is a cone spike, and the branch turns and divides again. The glume does not have a ridge line, but it has many veins and spreads on both sides. The spirit and the crown are wrapped with inner and outer spirit, hairy, and a groove is formed on one side. Fruits are made from oatmeal and are used as raw materials for alcohol and confectionery and for livestock feed.
귀리는 모노아민 옥시다아제 B(Monoamine Oxidase B, MAO-B)를 억제함으로써 잠재적인 신경보호제로 작용하며, 포스포디에스터라아제 4(Phosphodiesterase 4, PDE 4)를 억제함으로써 기분이 좋아지고 인지력이 향상되도록 해주며, 신경 진정, 이뇨, 인식력 부양 및 진통제 해독 보완제로 사용되어왔다.Oat acts as a potential neuroprotective agent by inhibiting monoamine oxidase B (MAO-B) and inhibits phosphodiesterase 4 (PDE 4) to improve mood and cognition And has been used as a neuro-sedative, diuretic, cognitive stimulant, and analgesic detoxifying additive.
본 발명의 귀리 추출물은 당업계에 공지된 통상의 방법에 따라, 즉, 통상적인 온도와 압력의 조건하에서 통상적인 용매를 사용하여 제조될 수 있다. 바람직하게는 물, 탄소수 1~4개의 무수 또는 함수 저급 알코올, 아세톤, 에틸아세테이트, 부틸아세테이트 및 1,3-부틸렌 글리콜로 구성된 군으로부터 선택되는 추출 용매로 상온에서 추출된 후, 여과 및 감압 농축하여 제조될 수 있다. The oats extract of the present invention can be prepared according to conventional methods known in the art, that is, using conventional solvents under the conditions of ordinary temperature and pressure. Preferably at a room temperature, with an extraction solvent selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1,3-butylene glycol, followed by filtration and concentration under reduced pressure .
본 발명의 유효성분인 귀리 추출물은 조성물의 1회 음용시 4 내지 800mg 양으로 섭취되는 것이 바람직하다. 이는 4mg 미만이면 그 효과가 미미하고, 800mg을 초과하면 섭취량 증가에 비해 효과의 증가가 크지 않아서 오히려 비효율적이기 때문이다.It is preferable that the oat extract as the active ingredient of the present invention is ingested in an amount of 4 to 800 mg when the composition is once consumed. This is because the effect is insignificant when the amount is less than 4 mg, and is ineffective if the amount is more than 800 mg because the increase in the effect is not large compared with the increase in the amount of the food.
본 발명의 데아닌과 귀리 추출물의 복합물은 심리적으로 안정시키고 집중력과 기억력을 높임으로써 궁극적으로는 학습 능력을 향상시키는 것을 특징으로 한다.The complex of the denier and oat extract of the present invention is characterized by psychological stabilization and enhancement of concentration and memory, ultimately improving learning ability.
본 발명의 식품 조성물은 음료, 환, 과립, 정제 또는 캡슐 등의 경구용 식 품 조성물을 비롯한 여러 제형의 식품으로 응용이 가능하다.The food composition of the present invention can be applied to foods of various formulations including oral food compositions such as drinks, rings, granules, tablets or capsules.
본 발명에서는 집중력, 기억력, 심리적 안정 및 학습 능력에 대한 객관적 규명을 위해서 뇌파 분석과 문제 풀이의 성공률을 측정하였으며, 실험한 실험자의 섭취 전후의 기분 변화를 설문을 통하여 비교하였다.In the present invention, the success rate of EEG analysis and problem solving was measured for objective identification of concentration, memory, psychological stability, and learning ability, and the mood changes before and after the experiment were compared through questionnaires.
이하에서는 실험예 및 제형예를 통하여 본 발명을 보다 구체적으로 설명하지만, 본 발명의 범위가 이들에만 국한되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to experimental examples and formulation examples, but the scope of the present invention is not limited thereto.
[제조예] 데아닌 및 귀리 추출물을 함유하는 조성물의 제조[Production Example] Preparation of a composition containing denier and oat extract
데아닌 및 귀리 추출물을 함유하는 조성물을 하기 표 1의 조성에 따라 각 성분들은 단순 혼합하여 제조하였다. 데아닌으로는 ㈜태양화학사의 상품명 Suntheanine을 사용하고, 귀리 추출물로는 프루타롬(Frutarom)사의 상품명 EFLA 955 Wild Green Oat Neuravena를 사용하였다. Denier and oat extract were prepared by simple mixing of the components according to the composition shown in Table 1 below. Suntheanine, a trade name of Sun Chemical Co., Ltd., was used as an oat extract, and EFLA 955 Wild Green Oat Neuravena, a product of Frutarom, was used as an oat extract.
(mg)Deni
(mg)
(mg)Oat extract
(mg)
[실험예 1] 집중력, 기억력 및 심리적 안정의 향상 효과에 대한 평가[Experimental Example 1] Evaluation of improvement effects of concentration, memory and psychological stability
데아닌과 귀리 추출물의 복합물의 집중력, 기억력 및 심리적 안정의 향상 효과를 평가하기 위하여 상기에서 제조된 조성물을 이용하여 뇌파 분석을 실시하였다. 그 구체적인 방법은 아래와 같다.In order to evaluate the effect of improving the concentration, memory and psychological stability of the complex of denier and oat extract, EEG analysis was performed using the composition prepared above. The concrete method is as follows.
신체 건강하고 현재 약물을 복용하지 않는 10~30대 남녀 각 12명씩을 조사 대상자로 선정하였다. 실험 전일에 무리한 운동이나 음주는 자제하도록 하였으며, 충분히 휴식을 취하고 검사 당일 아침 식사를 하고 측정하도록 하였다.Twelve male and female subjects aged between 10 and 30 who are physically healthy and do not take the current drug were selected as subjects. On the day before the experiment, exercise or drinking was prohibited, and enough rest was taken and breakfast was measured on the day of the test.
실험자에게 미치는 외부 환경의 영향을 최소화하기 위하여 내부 온도와 습도를 측정 전후 일정하게 유지하였으며, 측정 전 30분간 대기 장소에서 마음을 편안하게 쉬도록 하였다. 실험 시료를 섭취하기 전 뇌파를 측정하였다(문제풀이 포함). 그 후, 상기 4가지 조성물을 18℃ 물 100㎖에 완전히 녹여 섭취하도록 하였다. 섭취시 추가적인 자극이 없도록 안정된 분위기에서 5분 이내에 섭취하고 30분간 대기하도록 한 후, 음용 후의 뇌파를 측정(문제풀이 포함)하고 인지적 변화를 측정하였다. In order to minimize the influence of the external environment on the experimenter, the internal temperature and humidity were kept constant before and after the measurement, and the mind was rested comfortably in the waiting place for 30 minutes before the measurement. EEGs were measured before ingestion of the test samples (including problem solving). Thereafter, the four compositions were completely dissolved in 100 ml of water at 18 캜. In order to avoid any additional irritation during ingestion, the subjects were ingested within 5 minutes in a stable atmosphere and allowed to stand for 30 minutes. Then, EEGs were measured (including problem solving) and cognitive changes were measured.
뇌에는 생리적으로 발생되는 전기적 파형이 존재하며 이를 일반적으로 뇌파라고 말한다. 사람의 뇌파에는 알파파(α), 베타파(β), 세타파(θ) 및 델타파(δ)의 4가지가 존재한다. 평소 사람이 눈을 뜬 상태에서의 발생하는 뇌파는 베타파(12~23Hz)이며, 이는 뇌가 외계와 대응하여 긴장상태에서 왕성하게 사고의 작용을 하는 것을 나타내는데, 23~38Hz는 하이베타파(high β)로 뇌의 스트레스 지수로 사용된다. 알파파(8~12Hz)는 눈을 감은 상태에서 증가하는 것으로 알파파의 증가는 기억력, 집중력 및 창의력과 관련이 있음이 알려져 있다. 하이 알파파는 정신이 통일된 상태로 기억력과 집중력의 최대 상태시 나타난다. 세타파는(4~7Hz) 졸음상태나 얕은 수면일 때 발생하며, 델타파(0.5~4Hz)는 깊은 수면시에 발생한다. 따라서, 뇌파의 변화를 측정하여 이를 뇌의 생리지표로 사용하면 뇌의 상태를 확인할 수 있다.The brain has a physiologically generated electrical waveform, which is commonly referred to as an EEG. There are four kinds of human brain waves: alpha, beta, beta, and delta waves. The brain waves that occur when a person normally wakes up are beta waves (12-23 Hz), which indicates that the brain responds to the extraterrestrial and is actively thinking in a tense state. 23-38 Hz is a high beta wave high β) is used as a brain stress index. Alfapar (8-12 Hz) increases with eyes closed. It is known that the increase of alpha is related to memory, concentration and creativity. High alpha is a state of unity of mind and appears in the maximum state of memory and concentration. Cetaphas occur in the drowsy state (4-7 Hz) and shallow water, and delta waves (0.5-4 Hz) occur in deep sleep. Therefore, the state of the brain can be confirmed by measuring the change of EEG and using it as a physiological index of the brain.
상기 뇌파 측정 방법으로는 뇌파는 Fz 영역(입력된 정보를 자신의 저장된 정보와의 교류를 통해 사고 처리하는 영역)과 Oz 영역(정보의 직관적 입력 및 처리하는 영역)를 폐안 5분, 개안 5분, 폐안10분, 문제풀이 5분, 폐안 5분 순으로 시간에 따라 알파파, 하이알파파, 베타파 및 하이베타파를 동시적으로 측정하고, 그 변화에 따른 값을 수치화하였다. 이어서, 음료 섭취전의 뇌파의 값을 기본값으로 하여 섭취 후의 뇌파 변화를 분석하였다. 뇌파 중에서 집중시 높아지는 것으로 알려진 알파파의 피크(al pk)와 알파파와 하이베타파의 비율(al/hb)을 측정하고 각 뇌파 변화 측정 값에 대한 평균과 표준편차를 구하였다. 통계적 분석은 MINITAB을 이용하여 t-test로 검증하였다. 그 결과는 도 1~4에 나타내었고, 여기서 막대 모양은 95% 신뢰 수준에 들어오는 데이터의 범위를 나타내는 것이며 가운데 선은 데이터들의 평균을 나타낸다.In the EEG measurement method, the EEG is divided into the Fz area (the area where the inputted information is exchanged through the exchange of the stored information with the stored information) and the Oz area (the intuitive input and processing area of the information) , 10 minutes in the closed eye, 5 minutes in the problem solution, and 5 minutes in the closed eye, and the values according to the changes were measured by the simultaneous measurement of alpha, haalpapa, beta and high beta waves. Next, the EEG changes after ingestion were analyzed using the values of EEG before drinking. The mean (alpha) and standard deviation (a / hb) of alpha peaks (al pk) and alpha and high beta waves (alpha / hb) Statistical analysis was verified by t-test using MINITAB. The results are shown in FIGS. 1 to 4, where the bar shape represents the range of incoming data at the 95% confidence level and the middle line represents the average of the data.
도 1에서 알 수 있듯이, 데아닌만 섭취시에는 Fz 영역에서 알파파의 증가로 인하여 al/hb의 비율이 소폭 증가하였고, 귀리 추출물 한가지만 섭취시에는 al/hb의 변화가 섭취 전후로 크게 변화하지 않았다. 반면, 데아닌 및 귀리 추출물을 함께 섭취한 실험군에서는 모두 유의적으로 al/hb의 값이 증가하였다. 따라서, 본 발명의 데아닌과 귀리 추출물을 함께 섭취시에 사고 능력을 담당하는 Fz 뇌영역이 활성화됨으로써 학습시나 문제풀이 등 스트레스를 받을 수 있는 상황에서 집중력이 향상되고 스트레스는 감소되었다.As can be seen from FIG. 1, the ratio of al / hb was slightly increased due to the increase of alpha in the Fz region at the time of ingestion of deylan, and the change of al / hb was significantly changed before and after ingestion of only one oat extract I did. On the other hand, the values of al / hb were significantly increased in the experimental group consumed together with denier and oat extract. Therefore, the Fz brain region, which is responsible for thinking ability, is activated at the time of ingesting the denier and oat extract of the present invention, thereby improving concentration and stress in a situation where stress can be received, such as learning or problem solving.
도 2에서 알 수 있듯이, Oz 영역에서의 뇌파의 변화는 상기 Fz 영역에서의 뇌활성 패턴과 유사하게 나타나 데아닌 및 귀리 추출물을 함께 섭취한 실험군에서 al/hb가 유의하게 증가하였다. 따라서, 본 발명의 데아닌과 귀리 추출물을 함께 섭취시에 직관적 정보를 받아들이는 Oz 영역에서도 뇌가 활성화되었다.As can be seen from FIG. 2, the change of EEG in the Oz region was similar to the brain activity pattern in the Fz region, and al / hb was significantly increased in the experimental group in which oden extract was taken together. Thus, the brain was also activated in the Oz region, which receives intuitive information when ingesting the denier and oat extract of the present invention together.
도 3~4는 Fz 영역과 Oz 영역에서의 알파파의 피크(al pk)를 나타내었다. 알파파는 8~12Hz에서 발생하는 뇌파로서, 인지적인 뇌 활성이 강할수록 뇌파의 주파수가 높아지므로 뇌 활성도를 측정하는 지표로 사용될 수 있다.Figs. 3 to 4 show the peak (al pk) of the alpha wave in the Fz region and the Oz region. The alpha wave is an EEG occurring at 8 to 12 Hz. The higher the cognitive brain activity, the higher the frequency of EEG, which can be used as an indicator for brain activity.
도 3에서 알 수 있듯이, Fz 영역에서의 알파파의 주파수는 데아닌만 섭취한 실험군에서는 소폭 증가를 하였고, 귀리 추출물만을 섭취한 실험군에서는 변화가 없었다. 반면, 데아닌과 귀리 추출물을 함께 섭취한 실험군의 평균 알파파 주파수는 섭취 전후 각각 23.75%, 32.5%씩 증가하였다.As can be seen in FIG. 3, the frequency of the alpha waves in the Fz region was slightly increased in the experimental group consumed only in the denier and not in the experimental group consumed only the oat extract. On the other hand, the mean alpha frequency of the experimental group consumed together with denier and oat extract increased by 23.75% and 32.5% before and after ingestion, respectively.
도 4에서 알 수 있듯이, Oz 영역에서의 알파파의 피크 변화는 Fz영역에서의 변화보다는 다소 적었지만, 데아닌과 귀리 추출물을 함께 섭취한 실험군의 평균 알파파 주파수는 섭취 전후 각각 7.5%, 11.5%씩 증가하였으며, 이는 데아닌 또는 귀리 추출물을 단독으로 섭취한 실험군보다 향상된 증가폭이었다.As can be seen from FIG. 4, the peak change in the alpha level in the Oz region was somewhat less than the change in the Fz region, but the mean alpha frequency of the experimental group consumed together with the denier and oat extracts was 7.5% %, Which was an improvement over the experimental group consuming dane or oat extract alone.
따라서, 본 발명의 데아닌 및 귀리 추출물을 함께 섭취시 Fz 영역 및 Oz 영역에서 알파파의 피크의 주파수가 모두 높아져 인지적인 뇌 활성도가 강해짐을 확인할 수 있었다.Therefore, it was confirmed that caffeine activity of the present invention was enhanced by increasing the frequency of the peak of the alpha wave in the Fz region and the Oz region when the dandan and oat extracts of the present invention were taken together.
상기 4가지의 뇌파 분석을 근거로 데아닌과 귀리 추출물을 단독으로 섭취하는 경우와 비교하여 데아닌과 귀리 추출물을 함께 섭취하는 것이 더 높은 뇌파의 변화를 보여주었으며, 이는 뇌의 활성화에 데아닌과 귀리 추출물의 시너지 효과가 있음을 증명한다.Based on the above four EEG analyzes, it was shown that the ingestion of denien and oat extract together with the addition of denien and oat extract alone resulted in higher EEG changes, It demonstrates the synergistic effect of oat extract.
[실험예 2] 문제 풀이 성공률 확인[Experimental Example 2] Confirmation of success rate of problem solution
상기 제조예 1에서 얻은 조성물의 문제 풀이 성공률을 확인하기 위해서, 10~30대 남녀 각 12명씩을 조사 대상으로 하여 화면에 1초 동안 1부터 9까지의 숫자 중에서 8가지만 화면에 보이도록 하고 빠진 한가지 숫자를 3초 이내에 맞추는 방식으로 실험을 진행하였다. 이 문제풀이는 순간적인 정보 인지 속도와 외계로부터 받아들인 정보의 사고처리 속도를 확인하는 형식이며, 총 20문제를 풀게 하여 성공률을 음료 섭취 전후를 비교하고 그 변화를 분석하였다. 그 결과는 도 5에 나타내었다.In order to confirm the success rate of the problem solving of the composition obtained in the above Production Example 1, only 12 out of the
도 5에서 알 수 있듯이, 데아닌 또는 귀리 추출물을 단독으로 섭취한 실험군에서는 섭취 후 문제 풀이 성공률이 소폭 증가하였으나, 데아닌과 귀리 추출물을 함께 섭취한 실험군에서는 문제 풀이 성공률이 섭취 전후 각각 30%, 32.5%씩 크게 향상되었다. 따라서, 본 발명의 데아닌과 귀리 추출물은 강력한 시너지 효과를 나타내어 문제 사고의 인식 속도와 정확성을 효과적으로 증가시킴을 알 수 있었다.As can be seen from FIG. 5, the success rate of the problem solving after ingestion was slightly increased in the experimental group which received only the denien or oat extract, but in the experimental group which consumed the denien and oat extract, the success rate of the problem solving was 30% 32.5%, respectively. Therefore, it was found that the denier and oat extract of the present invention exhibit a strong synergy effect, effectively increasing the recognition speed and accuracy of the accident.
[실험예 3] 주관적 인지적 효과 평가[Experimental Example 3] Subjective cognitive effect evaluation
상기 제조예 1에서 얻은 조성물의 주관적 인지적 효과를 평가하기 위해서, 10~30대 남녀 각 12명씩을 조사 대상으로 하여 실험을 실시하였다. 주관적 인지적 효과 평가는 측정자가 느끼는 섭취 전후의 인지적 변화의 질문을 통하여 9점 척도로 평가하였다. 변화 없음을 0점으로 하고 확실한 기능성을 인지하였을 때 9점을 체크하도록 하였다. 기억력 개선, 심리적 안정, 머리의 맑음 정도, 스트레스 해소 및 집중력 향상의 5가지 항목에 대하여 질문하였고, 그 결과는 도 6에 나타내었다.In order to evaluate the subjective cognitive effect of the composition obtained in Preparation Example 1, twelve male and female subjects aged 10 to 30 were subjected to the experiment. Subjective cognitive effects were assessed on a 9-point scale through questions of cognitive changes before and after ingestion. When there is no change, it is set as 0 point, and when it is recognized as a certain function, 9 points are checked. The five items of memory improvement, psychological stability, degree of head clearness, relieving stress and improving concentration were asked, and the results are shown in FIG.
도 6에서 알 수 있듯이, 인지적 효과에서 기억력 개선은 큰 차이를 보이지 않았으며, 심리적 안정도는 데아닌 성분이 함유된 A, C 및 D에서만 평균 6.0 이상의 우수한 점수를 얻었다. 머리의 맑음 정도는 데아닌 및 귀리 추출물을 함유한 C 및 D에서 많이 개선되었고, 특히 데아닌 및 귀리 추출물의 함량이 높은 D에서 평균 5.3으로 가장 우수하였다. 스트레스 해소에 대한 평가도 심리적 안정 평가와 유사한 패턴을 보였으며, 집중력 향상에서는 데아닌과 귀리 추출물을 함께 섭취한 실험군에서 크게 향상됨이 발견되었다.As can be seen from FIG. 6, the memory improvement in the cognitive effect did not show a significant difference, and the psychological stability obtained an average score of 6.0 or higher in only A, C and D containing dementia. The degree of clearness of the head was improved most in C and D containing denier and oat extracts, and in D, which had a high content of denier and oat extract, the average was 5.3. Stress relief showed a pattern similar to that of psychological stability evaluation, and it was found that the improvement in concentration was significantly improved in the experimental group in which denier and oat extract were taken together.
따라서, 본 발명의 데아닌 및 귀리 추출물을 함께 섭취시 기억력 개선, 심리적 안정, 머리의 맑음 정도, 스트레스 해소 및 집중력 향상의 항목에서 전반적으로 우수한 인지적 효과를 나타내었으며, 특히 머리의 맑음 정도 및 집중력 향상에서 높은 만족도를 나타내었다.Therefore, the cognitive effects of the present invention on the improvement of memory, psychological stability, clarity of the head, relieving stress and improving the concentration of the oden extracts showed excellent cognitive effects, Satisfaction with the improvement.
하기에 상기 조성물의 제형예를 들어 설명하나, 본 발명이 이에 한정되는 것은 아니다.Hereinafter, formulation examples of the composition will be described, but the present invention is not limited thereto.
[제형예 1][Formulation Example 1]
집중력, 기억력, 심리적 안정 및 학습 능력 증진용 식품 조성물을 하기 표 2의 조성으로 제조하였다.A food composition for improving concentration, memory, psychological stability and learning ability was prepared with the composition shown in Table 2 below.
[제형예 2] [Formulation Example 2]
집중력, 기억력, 심리적 안정 및 학습 능력 증진용 식품 조성물을 하기 표 3의 조성으로 제조하였다.A food composition for improving concentration, memory, psychological stability and learning ability was prepared with the composition shown in Table 3 below.
도 1은 섭취 시료에 따른 Fz 영역에서의 알파파 및 하이베타파의 비율(al/hb)의 변화를 비교한 그래프이다.1 is a graph comparing changes in the ratio (al / hb) of the alpha and high beta waves in the Fz region according to the intake sample.
도 2는 섭취 시료에 따른 Oz 영역에서의 알파파 및 하이베타파의 비율(al/hb)의 변화를 비교한 그래프이다.2 is a graph comparing changes in the ratio (al / hb) of the alpha and high beta waves in the Oz region according to the ingested samples.
도 3은 섭취 시료에 따른 Fz 영역에서의 알파파 피크의 변화를 비교한 그래프이다.3 is a graph comparing changes in the alpha peak in the Fz region according to the ingested sample.
도 4는 섭취 시료에 따른 Oz 영역에서의 알파파 피크의 변화를 비교한 그래프이다.4 is a graph comparing changes in the alpha peak in the Oz region according to the ingested sample.
도 5는 섭취 시료에 따른 문제 풀이 성공률을 비교한 그래프이다.5 is a graph comparing the success rate of the problem solving according to the ingested sample.
도 6은 섭취 시료에 따른 주관적 인지적 효과의 평가를 비교한 그래프이다.FIG. 6 is a graph comparing the evaluation of the subjective cognitive effect according to the ingested sample.
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| PCT/KR2010/004001 WO2011040697A1 (en) | 2009-10-01 | 2010-06-21 | Food composition containing concentrate of theanine and oat extract for promoting memory, learning ability and psychological stability |
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| KR20180083783A (en) | 2017-01-13 | 2018-07-23 | 주식회사 아미코스메틱 | Cosmetic composition comprising corn oil, extracts of avena sativa, hordeum vulgare or triticum aestivum |
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| ITGE20110050A1 (en) * | 2011-04-29 | 2012-10-30 | Marco Zipoli | FOOD, IN PARTICULAR A DRINK FOR HUMAN CONSUMPTION |
| EP4075986A1 (en) * | 2019-12-20 | 2022-10-26 | Clutch Cognition ApS | Nutraceutical composition for mental activity |
| US11839622B1 (en) | 2020-01-15 | 2023-12-12 | Randall Lewarchik | Consumable nutraceutical composition |
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| KR0162536B1 (en) * | 1995-10-05 | 1998-11-16 | 이능희 | Process for preparing tea |
| WO1999042096A1 (en) * | 1998-02-23 | 1999-08-26 | Taiyo Kagaku Co., Ltd. | Composition comprising theanine |
| KR20000006978A (en) * | 1999-11-12 | 2000-02-07 | 류종원 | Composition of tea mixed green tea, oat and herbs. |
| KR100388668B1 (en) * | 2000-04-25 | 2003-06-25 | 박동기 | The preparation method of the solid-type functional food |
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| KR20050112222A (en) * | 2004-05-25 | 2005-11-30 | 주식회사 보락 | The use of oat polysaccharide for depression of blood glucose |
| KR100606553B1 (en) * | 2004-06-22 | 2006-08-01 | 씨제이 주식회사 | Functional Beverage Composition for Improving Ability of Learning, Concentration and Memory |
| KR20060054601A (en) * | 2004-11-15 | 2006-05-23 | 주식회사 크라우젠 | Herbal mixed-extract improving memory and composition comprising thereof |
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| KR101354370B1 (en) * | 2008-01-29 | 2014-02-18 | 주식회사 엘지생활건강 | A composition for improving ability of memory or concentration |
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| Journal of Herbal Pharmacotherapy. 2006, Vol.6, No.2, pp.21-30* |
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