WO2011028195A3 - Compositions contenant et procédés faisant intervenir des acides aminés et polypeptides non naturels et utilisations de ceux-ci - Google Patents
Compositions contenant et procédés faisant intervenir des acides aminés et polypeptides non naturels et utilisations de ceux-ci Download PDFInfo
- Publication number
- WO2011028195A3 WO2011028195A3 PCT/US2007/088009 US2007088009W WO2011028195A3 WO 2011028195 A3 WO2011028195 A3 WO 2011028195A3 US 2007088009 W US2007088009 W US 2007088009W WO 2011028195 A3 WO2011028195 A3 WO 2011028195A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- natural amino
- polypeptides
- amino acids
- amino acid
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
Abstract
L'invention concerne des acides aminés et polypeptides non naturels qui comportent au moins un acide aminé non naturel, et des procédés d'élaboration de ces produits. Les acides aminés non naturels, pris en eux-mêmes ou intégrés à un polypeptide, peuvent comprendre une large gamme de fonctionnalités, mais généralement ils comportent au moins un groupe indole, carbonyle, et/ou hydrazine. L'invention concerne également des polypeptides d'acides aminés non naturels qui sont modifiés plus avant de façon post-translationnelle, des procédés permettant de réaliser ces modifications et des procédés de purification de tels polypeptides. En règle générale, les polypeptides d'acides aminés non naturels modifiés comportent au moins un groupe indole, carbonyle et/ou hydrazine. On décrit par ailleurs des procédés d'utilisation de ces polypeptides d'acides aminés non naturels et des mêmes polypeptides modifiés, y compris des applications thérapeutiques, diagnostiques et autres applications de biotechnologie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87059406P | 2006-12-18 | 2006-12-18 | |
US60/870,594 | 2006-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011028195A2 WO2011028195A2 (fr) | 2011-03-10 |
WO2011028195A3 true WO2011028195A3 (fr) | 2011-06-16 |
Family
ID=39536734
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/088011 WO2008077079A1 (fr) | 2006-12-18 | 2007-12-18 | Compositions renfermant des acides aminés non naturels et polypeptides, procédés impliquant lesdits acides aminés non naturels et polypeptides et utilisations de ces derniers |
PCT/US2007/088009 WO2011028195A2 (fr) | 2006-12-18 | 2007-12-18 | Compositions contenant et procédés faisant intervenir des acides aminés et polypeptides non naturels et utilisations de ceux-ci |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/088011 WO2008077079A1 (fr) | 2006-12-18 | 2007-12-18 | Compositions renfermant des acides aminés non naturels et polypeptides, procédés impliquant lesdits acides aminés non naturels et polypeptides et utilisations de ces derniers |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2079687A1 (fr) |
JP (1) | JP2010512800A (fr) |
KR (1) | KR20090100407A (fr) |
CN (1) | CN101578264A (fr) |
AU (1) | AU2007333737A1 (fr) |
CA (1) | CA2672205A1 (fr) |
MX (1) | MX2009006617A (fr) |
WO (2) | WO2008077079A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102307905B (zh) * | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
WO2010096394A2 (fr) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Véhicules de médicaments à base de protéine marqués par aldéhyde et procédés d'utilisation |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
HRP20240267T1 (hr) * | 2010-08-17 | 2024-05-10 | Ambrx, Inc. | Modificirani relaksin polipeptidi i njihove uporabe |
KR20140016262A (ko) | 2011-01-14 | 2014-02-07 | 레드우드 바이오사이언스 인코포레이티드 | 알데하이드-태깅된 면역글로불린 폴리펩타이드 및 이의 사용 방법 |
EP2820030A4 (fr) * | 2012-02-29 | 2015-04-15 | Ambrx Inc | Conjugués polypeptidiques d'interleukine-3 et leurs utilisations |
US20150018530A1 (en) * | 2012-02-29 | 2015-01-15 | Ambrx, Inc. | Novel Prodrug Containing Molecule Compositions and Their Uses |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP2858676B1 (fr) * | 2012-06-07 | 2019-03-13 | Ambrx, Inc. | Conjugués anticorps-médicament d'antigène membranaire spécifique à la prostate |
EP3488870B1 (fr) | 2012-06-19 | 2024-03-20 | Ambrx, Inc. | Conjugués anticorps-médicament anti-cd70 |
EP2970505A4 (fr) | 2013-03-14 | 2016-10-19 | California Inst Biomedical Res | Anticorps bispécifiques et leurs utilisations |
JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
CA2927543C (fr) | 2013-10-15 | 2021-07-20 | The California Institute For Biomedical Research | Commutateurs de cellules t a recepteur d'antigene chimere peptidique et leurs utilisations |
WO2016154621A1 (fr) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | Récepteurs chimériques non-scfv commutables, commutateurs, et leurs utilisations |
WO2016168773A2 (fr) | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Commutateurs de lymphocytes t à récepteurs d'antigènes chimères à base de pne optimisés et leurs utilisations |
CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
KR102613430B1 (ko) | 2016-10-19 | 2023-12-18 | 더 스크립스 리서치 인스티튜트 | 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도 |
KR102670432B1 (ko) | 2017-02-08 | 2024-05-28 | 브리스톨-마이어스 스큅 컴퍼니 | 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 |
HUE065882T2 (hu) | 2018-09-11 | 2024-06-28 | Ambrx Inc | Interleukin-2-polipeptid-konjugátumok és alkalmazásaik |
JP2022533145A (ja) * | 2019-05-13 | 2022-07-21 | シャンハイ ポラリス バイオロジー カンパニー, リミテッド | 生体分子を標識するためのタグ |
CN114524934B (zh) * | 2020-11-23 | 2024-01-30 | 华东理工大学 | 多肽聚合物或多肽模拟物在骨修复中的应用 |
JPWO2023282315A1 (fr) * | 2021-07-07 | 2023-01-12 | ||
WO2024077277A1 (fr) | 2022-10-07 | 2024-04-11 | Ambrx, Inc. | Lieurs de médicaments et conjugués d'anticorps associés |
WO2024155627A1 (fr) | 2023-01-16 | 2024-07-25 | Ambrx, Inc. | Conjugués anticorps-médicament anti-cd70 |
WO2024178310A1 (fr) | 2023-02-23 | 2024-08-29 | Ambrx, Inc. | Conjugués anticorps-médicament dirigés contre trop2 et utilisations associées |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999052539A1 (fr) * | 1998-04-10 | 1999-10-21 | Mayo Foundation For Medical Education And Research | Neo-tryptophane |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9709875A (es) * | 1995-06-06 | 1998-03-31 | Pfizer | N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas. |
US6858577B1 (en) * | 1999-06-29 | 2005-02-22 | Ortho-Mcneil Pharmaceutical, Inc. | Indole peptidomimetics as thrombin receptor antagonists |
AU2001260661A1 (en) * | 2000-05-30 | 2001-12-11 | Chugai Seiyaku Kabushiki Kaisha | Compounds exhibiting thrombopoietin-like activities |
US7129225B2 (en) * | 2001-10-22 | 2006-10-31 | The Research Foundation Of State University Of New York | Protection against and treatment of hearing loss |
-
2007
- 2007-12-18 WO PCT/US2007/088011 patent/WO2008077079A1/fr active Application Filing
- 2007-12-18 CN CNA2007800469737A patent/CN101578264A/zh active Pending
- 2007-12-18 CA CA002672205A patent/CA2672205A1/fr not_active Abandoned
- 2007-12-18 WO PCT/US2007/088009 patent/WO2011028195A2/fr active Application Filing
- 2007-12-18 JP JP2009543156A patent/JP2010512800A/ja active Pending
- 2007-12-18 KR KR1020097014780A patent/KR20090100407A/ko not_active Application Discontinuation
- 2007-12-18 AU AU2007333737A patent/AU2007333737A1/en not_active Abandoned
- 2007-12-18 MX MX2009006617A patent/MX2009006617A/es not_active Application Discontinuation
- 2007-12-18 EP EP07869463A patent/EP2079687A1/fr not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999052539A1 (fr) * | 1998-04-10 | 1999-10-21 | Mayo Foundation For Medical Education And Research | Neo-tryptophane |
Non-Patent Citations (3)
Title |
---|
CARLIER, PAUL R. ET AL.: "Catalytic Asymmetric Synthesis of Protected Tryptophan Regioisomers.", JOURNAL OF ORGANIC CHEMISTRY, vol. 67, 2002, pages 6256 - 6259 * |
FAUQ, ABDUL H. ET AL.: "Synthesis of (25)-2-amino-3-(lH-4-indolyl)propanoic acid, a novel tryptophan analog for structural modification of bioactive peptides.", TETRAHEDRON: ASYMMETRY, vol. 9, 1998, pages 4127 - 4134 * |
TROXLER, FRANZ.: "Synthetic indole compounds. IV. Preparative Application of Mannich Bases of Hydroxyindoles as Alkylation agents.", HELVETICA CHIMICA ACTA, vol. 51, 1968, pages 1214 - 1224 * |
Also Published As
Publication number | Publication date |
---|---|
KR20090100407A (ko) | 2009-09-23 |
WO2011028195A2 (fr) | 2011-03-10 |
AU2007333737A1 (en) | 2008-06-26 |
WO2008077079A1 (fr) | 2008-06-26 |
EP2079687A1 (fr) | 2009-07-22 |
MX2009006617A (es) | 2009-07-24 |
JP2010512800A (ja) | 2010-04-30 |
CA2672205A1 (fr) | 2008-06-26 |
CN101578264A (zh) | 2009-11-11 |
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