WO2011006161A3 - Compositions et procédés permettant de diagnostiquer et de traiter la dégénérescence maculaire - Google Patents

Compositions et procédés permettant de diagnostiquer et de traiter la dégénérescence maculaire Download PDF

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Publication number
WO2011006161A3
WO2011006161A3 PCT/US2010/041720 US2010041720W WO2011006161A3 WO 2011006161 A3 WO2011006161 A3 WO 2011006161A3 US 2010041720 W US2010041720 W US 2010041720W WO 2011006161 A3 WO2011006161 A3 WO 2011006161A3
Authority
WO
WIPO (PCT)
Prior art keywords
macular degeneration
compositions
methods
diagnosing
treating macular
Prior art date
Application number
PCT/US2010/041720
Other languages
English (en)
Other versions
WO2011006161A2 (fr
Inventor
Anand Swaroop
Gonçalo ABECASIS
Wei Chen
Albert O. Edwards
Dwight Stambolian
Original Assignee
The Regents Of The University Of Michigan
Mayo Foundation For Medical Education And Research
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan, Mayo Foundation For Medical Education And Research, The Trustees Of The University Of Pennsylvania filed Critical The Regents Of The University Of Michigan
Priority to EP20100797971 priority Critical patent/EP2451983B1/fr
Priority to CA2781595A priority patent/CA2781595C/fr
Publication of WO2011006161A2 publication Critical patent/WO2011006161A2/fr
Publication of WO2011006161A3 publication Critical patent/WO2011006161A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne en général des biomarqueurs de la dégénérescence maculaire. En particulier, elle concerne une pluralité de biomarqueurs permettant de surveiller et de diagnostiquer la dégénérescence maculaire. Les compositions et les méthodes de la présente invention trouvent une utilisation dans des applications diagnostiques, thérapeutiques, de recherche et de criblage de médicaments.
PCT/US2010/041720 2009-07-10 2010-07-12 Compositions et procédés permettant de diagnostiquer et de traiter la dégénérescence maculaire WO2011006161A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20100797971 EP2451983B1 (fr) 2009-07-10 2010-07-12 Procédés permettant de diagnostiquer la dégénérescence maculaire
CA2781595A CA2781595C (fr) 2009-07-10 2010-07-12 Compositions et procedes permettant de diagnostiquer et de traiter la degenerescence maculaire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22475309P 2009-07-10 2009-07-10
US61/224,753 2009-07-10

Publications (2)

Publication Number Publication Date
WO2011006161A2 WO2011006161A2 (fr) 2011-01-13
WO2011006161A3 true WO2011006161A3 (fr) 2011-06-16

Family

ID=43429871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/041720 WO2011006161A2 (fr) 2009-07-10 2010-07-12 Compositions et procédés permettant de diagnostiquer et de traiter la dégénérescence maculaire

Country Status (4)

Country Link
US (2) US8119348B2 (fr)
EP (2) EP2963128A1 (fr)
CA (1) CA2781595C (fr)
WO (1) WO2011006161A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010229767C1 (en) * 2009-03-27 2015-02-19 The General Hospital Corporation Markers related to age-related macular degeneration and uses therefor
CN103215265B (zh) * 2012-05-14 2015-02-18 四川省医学科学院（四川省人民医院） 一种老年黄斑变性疾病的筛查试剂盒
CN104293886A (zh) * 2013-07-16 2015-01-21 浙江爱易生物医学科技有限公司 一种用荧光sybr方法检测黄斑变性基因位点的试剂盒
KR20180021234A (ko) 2013-08-12 2018-02-28 제넨테크, 인크. 보체-연관 상태의 치료를 위한 조성물 및 방법
WO2015168468A1 (fr) 2014-05-01 2015-11-05 Genentech, Inc. Variants d'anticorps anti-facteur d et leurs utilisations
EP3368090A1 (fr) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Conjugués de variants d'anticorps anti-facteur d et leurs utilisations
JP2018534930A (ja) 2015-10-30 2018-11-29 ジェネンテック， インコーポレイテッド 抗ｄ因子抗体及びコンジュゲート

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US5643765A (en) 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5876978A (en) 1993-04-06 1999-03-02 Medical College Of Ohio Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US7312050B2 (en) 1998-10-29 2007-12-25 University Of Iowa Research Foundation Nucleic acids encoding interphotoreceptor matrix proteins
US6417342B1 (en) 1999-02-12 2002-07-09 University Of Iowa Research Foundation Macular degeneration diagnostics and therapeutics
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US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
WO2001084149A2 (fr) 2000-04-29 2001-11-08 University Of Iowa Research Foundation Diagnostic et therapeutique pour des troubles lies a une degenerescence maculaire
US7351534B2 (en) 2003-01-27 2008-04-01 Oregon Health & Sciences University Gene mutation associated with age-related macular degeneration
US7309487B2 (en) 2004-02-09 2007-12-18 George Inana Methods and compositions for detecting and treating retinal diseases
NZ595305A (en) 2005-02-14 2013-06-28 Univ Iowa Res Found Methods and reagents for treatment and diagnosis of age-related macular degeneration
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Also Published As

Publication number Publication date
EP2451983A4 (fr) 2012-12-05
EP2963128A1 (fr) 2016-01-06
EP2451983B1 (fr) 2015-05-06
US20120135884A1 (en) 2012-05-31
US8119348B2 (en) 2012-02-21
CA2781595A1 (fr) 2011-01-13
US20110014716A1 (en) 2011-01-20
CA2781595C (fr) 2016-07-05
EP2451983A2 (fr) 2012-05-16
WO2011006161A2 (fr) 2011-01-13

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