WO2010133569A1 - Dérivés d'azabicyclo[4.1.0]heptane - Google Patents

Dérivés d'azabicyclo[4.1.0]heptane Download PDF

Info

Publication number
WO2010133569A1
WO2010133569A1 PCT/EP2010/056774 EP2010056774W WO2010133569A1 WO 2010133569 A1 WO2010133569 A1 WO 2010133569A1 EP 2010056774 W EP2010056774 W EP 2010056774W WO 2010133569 A1 WO2010133569 A1 WO 2010133569A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
dichlorophenyl
disorder
azabicyclo
mmol
Prior art date
Application number
PCT/EP2010/056774
Other languages
English (en)
Inventor
Giorgio Bonanomi
Fabrizio Micheli
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of WO2010133569A1 publication Critical patent/WO2010133569A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La présente invention concerne des composés de formule (I), des procédés pour les préparer, des intermédiaires utilisés dans ces procédés, des compositions pharmaceutiques les contenant et leur utilisation en thérapeutique, en tant qu'inhibiteurs de la recapture de la sérotonine (5-HT), de la dopamine (DA) et de la norépinéphrine (NE).
PCT/EP2010/056774 2009-05-20 2010-05-18 Dérivés d'azabicyclo[4.1.0]heptane WO2010133569A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17979809P 2009-05-20 2009-05-20
US61/179,798 2009-05-20

Publications (1)

Publication Number Publication Date
WO2010133569A1 true WO2010133569A1 (fr) 2010-11-25

Family

ID=42226637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/056774 WO2010133569A1 (fr) 2009-05-20 2010-05-18 Dérivés d'azabicyclo[4.1.0]heptane

Country Status (1)

Country Link
WO (1) WO2010133569A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102906102A (zh) * 2010-03-31 2013-01-30 吉利德制药有限责任公司 含磷活性物的立体选择性合成

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031772A1 (fr) * 2006-09-11 2008-03-20 Glaxo Group Limited Composés azabicycliques en tant qu'inhibiteurs de réabsorption de monoamines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031772A1 (fr) * 2006-09-11 2008-03-20 Glaxo Group Limited Composés azabicycliques en tant qu'inhibiteurs de réabsorption de monoamines

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
BERGE ET AL., J. PHARM, SCI., vol. 66, 1977, pages 1 - 19
CHENG; PRUSOFF, BIOCHEM. PHARMACOL., vol. 22, 1973, pages 3099
CONDREAY JP ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 127 - 132
DYATKIN AB ET AL., CHIRALITY, vol. 14, 2002, pages 215 - 219
FREEDMAN TB ET AL., HELV CHIM ACTA, vol. 85, 2002, pages 1160 - 1165
H. GU; S.C. WALL; G. RUDNICK, J. BIOL. CHEM, vol. 269, 1994, pages 7124 - 7130
HASSAN NJ ET AL., PROTEIN EXPRESSION AND PURIFICATION, vol. 47, no. 2, 2006, pages 591 - 598
MICHAEL J. OWENS ET AL.: "Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites", JPET, vol. 283, 1997, pages 1305 - 1322
P L GOULD, INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 33, 1986, pages 201 - 217
PER ALLARD; JAN O. MARCUSSON; SVATE B. ROSS: "[3H]WIN-35,428 binding in the human brain", BRAIN RES., vol. 706, 1996, pages 347 - 350, XP022255592, DOI: doi:10.1016/0006-8993(95)01345-8
POLAVARAPU PL ET AL., J ANAL CHEM, vol. 366, 2000, pages 727 - 734
SHAH RD, CURR OPIN DRUG DISC DEV, vol. 4, 2001, pages 764 - 774
SOLLADIE -CAVALLO A ET AL., EUR J ORG CHEM, 2002, pages 1788 - 1796
SOLLADIE'-CAVALLO A; BALAZ M ET AL., TETRAHEDRON ASSYM, vol. 12, 2001, pages 2605 - 2611
STEPHENS PJ ET AL., CHIRALITY, vol. 12, 2000, pages 172 - 179

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102906102A (zh) * 2010-03-31 2013-01-30 吉利德制药有限责任公司 含磷活性物的立体选择性合成
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives

Similar Documents

Publication Publication Date Title
US7691893B2 (en) Chemical compounds
AU2018201653B2 (en) Novel compounds
WO2010007032A1 (fr) Urées à base de pipéridine en tant qu’antagonistes du nk1
EP2061461B1 (fr) Derives du 3-azabicyclyo[4.1.0]heptane pour le traitement de la depression
US20100029740A1 (en) Azabicyclic compounds as serotonin, dopamine and norepinephrine re-uptake inhibitors
WO2010133569A1 (fr) Dérivés d'azabicyclo[4.1.0]heptane
WO2009056520A1 (fr) Dérivés d'azabicyclo[3.2.1]octane
CA2723062C (fr) Spiro (piperidine-4, 2 ' -pyrrolidine) -1- (3, 5- tri fluoromethyl phenyle) methylcarboxamides en tant qu'antagonistes du recepteur nk1 tachikynine
WO2009027293A1 (fr) Composés
WO2009109608A1 (fr) Nouveaux composés
WO2010130672A1 (fr) Dérivés de l'azabicyclo [4.1.0] heptane et leur utilisation en tant qu'inhibiteurs de recapture de monoamines
WO2009141412A1 (fr) Dérivés de 3-azabicyclo [3.1.0] hexane 1,6 disubstitués destinés à être utilisés comme triples inhibiteurs de recaptage
WO2010146025A1 (fr) Dérivés d'azabicyclo [4.1.0] heptane tricycliques utilisés comme inhibiteurs du recaptage de la sérotonine, de la dopamine et de la norépinéphrine
WO2010125033A1 (fr) Dérivés d'azabicyclo[4.1.0]heptane
WO2009027295A1 (fr) Dérivés de 3-azabicyclo(4.1.0)heptane utiles comme inhibiteurs de la réabsorption de la norépinéphrine, de la sérotonine ou de la dopamine
WO2009027294A1 (fr) Composés azabicyclo [4.1.0] heptanes substitués pour une utilisation en tant qu'inhibiteurs de la réabsorption de monoamine
US20100190764A1 (en) Novel compounds
CN101541754A (zh) 作为单胺类重摄取抑制剂的氮杂双环化合物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10719359

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10719359

Country of ref document: EP

Kind code of ref document: A1