WO2010118968A1 - Dérivés d'aspirine donneurs de no - Google Patents

Dérivés d'aspirine donneurs de no Download PDF

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Publication number
WO2010118968A1
WO2010118968A1 PCT/EP2010/054493 EP2010054493W WO2010118968A1 WO 2010118968 A1 WO2010118968 A1 WO 2010118968A1 EP 2010054493 W EP2010054493 W EP 2010054493W WO 2010118968 A1 WO2010118968 A1 WO 2010118968A1
Authority
WO
WIPO (PCT)
Prior art keywords
arom
compound
mmol
group
nmr
Prior art date
Application number
PCT/EP2010/054493
Other languages
English (en)
Inventor
Alberto Gasco
Roberta Fruttero
Loretta Lazzarato
Barbara Rolando
Konstantin Chegaev
Monica Donnola
Ennio Ongini
Stefano Biondi
Original Assignee
Nicox S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox S.A. filed Critical Nicox S.A.
Publication of WO2010118968A1 publication Critical patent/WO2010118968A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cardiology (AREA)

Abstract

La présente invention porte sur des dérivés de l'aspirine donneurs d'oxyde nitrique, sur un procédé pour leur préparation et sur des compositions pharmaceutiques les contenant. R est choisi dans le groupe constitué par A) (R0) t -CH (ONO2) -R2 B) (R0) t - CH (ONO2 ) - (CR3R4 ) P-CH (ONO2 ) -R2 C) (R0) t -O- (CR3R4 ) n -CH (ONO2) -R2 D) (R0) t -O- (CR3R4 ) n -CH (ONO2 ) - (CR3R4 ) P-CH (ONO2 ) –R2.
PCT/EP2010/054493 2009-04-16 2010-04-06 Dérivés d'aspirine donneurs de no WO2010118968A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09158061.3 2009-04-16
EP09158061 2009-04-16

Publications (1)

Publication Number Publication Date
WO2010118968A1 true WO2010118968A1 (fr) 2010-10-21

Family

ID=42224844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/054493 WO2010118968A1 (fr) 2009-04-16 2010-04-06 Dérivés d'aspirine donneurs de no

Country Status (1)

Country Link
WO (1) WO2010118968A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105037180A (zh) * 2015-04-19 2015-11-11 安徽省逸欣铭医药科技有限公司 一种双重作用的中枢性镇痛新化合物、制备方法及用途
US10561650B2 (en) 2013-03-14 2020-02-18 Christopher Brian Reid Method for treating a protozoal infection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359110A1 (fr) * 1976-07-21 1978-02-17 Rohm & Haas Derives de l'acide salicylique, leur obtention et compositions pharmaceutiques les contenant
WO1992001668A1 (fr) 1990-07-26 1992-02-06 Italfarmaco S.P.A. Derives substitues d'acide benzoique possedant une efficacite cardiovasculaire
WO1995030641A1 (fr) 1994-05-10 1995-11-16 Nicox S.A. Composes nitro et compositions les contenant qui possedent une activite anti-inflammatoire, analgesique et antithrombotique
WO1997016405A1 (fr) 1995-10-31 1997-05-09 Nicox S.A. Nouveaux composes et leurs compositions possedant des activites anti-inflammatoires et antithrombotiques
US5859053A (en) 1995-05-02 1999-01-12 Bayer Aktiengesellschaft Acetylsalicylic acid nitrates
WO2004018484A1 (fr) 2002-08-23 2004-03-04 Pfizer Products Inc. Promedicament inhibiteur de beta-lactamase

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359110A1 (fr) * 1976-07-21 1978-02-17 Rohm & Haas Derives de l'acide salicylique, leur obtention et compositions pharmaceutiques les contenant
WO1992001668A1 (fr) 1990-07-26 1992-02-06 Italfarmaco S.P.A. Derives substitues d'acide benzoique possedant une efficacite cardiovasculaire
WO1995030641A1 (fr) 1994-05-10 1995-11-16 Nicox S.A. Composes nitro et compositions les contenant qui possedent une activite anti-inflammatoire, analgesique et antithrombotique
US5859053A (en) 1995-05-02 1999-01-12 Bayer Aktiengesellschaft Acetylsalicylic acid nitrates
WO1997016405A1 (fr) 1995-10-31 1997-05-09 Nicox S.A. Nouveaux composes et leurs compositions possedant des activites anti-inflammatoires et antithrombotiques
WO2004018484A1 (fr) 2002-08-23 2004-03-04 Pfizer Products Inc. Promedicament inhibiteur de beta-lactamase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EMANUELI C ET AL: "Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia", November 2004, ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY 200411 US LNKD- DOI:10.1161/01.ATV.0000144030.39087.3B, VOL. 24, NR. 11, PAGE(S) 2082 - 2087, ISSN: 1079-5642, XP002586409 *
GOODMAN: "Gilman's The Pharmacological Basis of Therapeutics", MCGRAW-HILL
GOODMAN: "Gilman's, The Pharmacological Basis of Therapeutics", pages: 687 - 716
T. W. GREENE: "Protective groups in organic synthesis", 1980, HARVARD UNIVERSITY PRESS
WERMUTH, C.G.; STAHL, P.H.: "Pharmaceutical Salts: Properties, Selection, and Use - A Handbook Verlag Helvetica Chimica Acta", 2002

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10561650B2 (en) 2013-03-14 2020-02-18 Christopher Brian Reid Method for treating a protozoal infection
CN105037180A (zh) * 2015-04-19 2015-11-11 安徽省逸欣铭医药科技有限公司 一种双重作用的中枢性镇痛新化合物、制备方法及用途

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