WO2010113183A3 - Process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl] pyrrolidine and its pharmaceutically acceptable salts - Google Patents

Process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl] pyrrolidine and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2010113183A3
WO2010113183A3 PCT/IN2010/000216 IN2010000216W WO2010113183A3 WO 2010113183 A3 WO2010113183 A3 WO 2010113183A3 IN 2010000216 W IN2010000216 W IN 2010000216W WO 2010113183 A3 WO2010113183 A3 WO 2010113183A3
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WO
WIPO (PCT)
Prior art keywords
indol
pyrrolidine
sulfonyl
dimethylamino
ethyl
Prior art date
Application number
PCT/IN2010/000216
Other languages
French (fr)
Other versions
WO2010113183A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Maramreddy Sahadeva Reddy
Komati Satyanarayana
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2010113183A2 publication Critical patent/WO2010113183A2/en
Publication of WO2010113183A3 publication Critical patent/WO2010113183A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine of Formula (1), which is commonly known as Almotriptan, and its pharmaceutically acceptable salts is provided. The required purity of almotriptan malate free of impurities is attained in three different ways, including by preparing the acid addition salts of amino indole compound, by proceeding through the almotriptan succinate and by specific purification of almotriptan malate from a suitable solvent.
PCT/IN2010/000216 2009-04-03 2010-04-01 Process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl] pyrrolidine and its pharmaceutically acceptable salts WO2010113183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN774CH2009 2009-04-03
IN774/CHE/2009 2009-04-03
IN546/CHE/2010 2010-03-03
IN546CH2010 2010-03-03

Publications (2)

Publication Number Publication Date
WO2010113183A2 WO2010113183A2 (en) 2010-10-07
WO2010113183A3 true WO2010113183A3 (en) 2010-12-29

Family

ID=42828790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000216 WO2010113183A2 (en) 2009-04-03 2010-04-01 Process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl] pyrrolidine and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2010113183A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012085723A1 (en) * 2010-12-20 2012-06-28 Orchid Chemicals And Pharmaceuticals Limited A process for the purification of almotriptan acid addition salt
BR112013020362A2 (en) 2011-02-10 2018-05-29 Exelixis Inc processes for the preparation of quinoline compounds, compounds and pharmaceutical combinations containing them
CN102827062A (en) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 Method for preparing almotriptan malate
ES2505715T1 (en) 2013-02-06 2014-10-10 Galenicum Health S.L. Pharmaceutical composition comprising almotriptan malate having a uniform distribution and potency
CN103353494B (en) * 2013-07-04 2014-12-31 山东省医药工业研究所 HPLC (high performance liquid chromatography) detection method of related substances in almotriptan malate
CN106397359B (en) * 2016-08-31 2017-12-05 重庆华森制药股份有限公司 The preparation method of almotriptan intermediate 4 (1 pyrrolidinyl sulfonymethyl) phenylhydrazine
CN106478484B (en) * 2016-08-31 2017-11-10 重庆华森制药股份有限公司 A kind of method for preparing almotriptan key intermediate
CN109928910B (en) * 2017-12-19 2022-07-22 上海医药工业研究院 Preparation method of anti-migraine drug almotriptan

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013098A1 (en) * 2005-07-25 2007-02-01 Matrix Laboratories Limited A process for the preparation of almotriptan
WO2008151584A1 (en) * 2007-06-13 2008-12-18 Zentiva, A.S. Method for the preparation of high purity almotriptan

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013098A1 (en) * 2005-07-25 2007-02-01 Matrix Laboratories Limited A process for the preparation of almotriptan
WO2008151584A1 (en) * 2007-06-13 2008-12-18 Zentiva, A.S. Method for the preparation of high purity almotriptan

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUMAR, A. PHANI ET AL.: "A Validated Reversed Phase HPLC Method for the Determination of Process-Related Impurities in Almotriptan Malate API.", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 46, 2008, pages 792 - 798 *

Also Published As

Publication number Publication date
WO2010113183A2 (en) 2010-10-07

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