WO2008072257A3 - Process for the preparation of indole derivatives - Google Patents

Process for the preparation of indole derivatives Download PDF

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Publication number
WO2008072257A3
WO2008072257A3 PCT/IN2007/000571 IN2007000571W WO2008072257A3 WO 2008072257 A3 WO2008072257 A3 WO 2008072257A3 IN 2007000571 W IN2007000571 W IN 2007000571W WO 2008072257 A3 WO2008072257 A3 WO 2008072257A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
indole derivatives
relates
present
novel
Prior art date
Application number
PCT/IN2007/000571
Other languages
French (fr)
Other versions
WO2008072257A2 (en
Inventor
Ashvin Kumar Aggarwal
Gurdeep Singh Sarin
Chidambaram Venkateswaran Srinivasan
Lalit Wadhwa
Original Assignee
Ind Swift Lab Ltd
Ashvin Kumar Aggarwal
Gurdeep Singh Sarin
Chidambaram Venkateswaran Srinivasan
Lalit Wadhwa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Swift Lab Ltd, Ashvin Kumar Aggarwal, Gurdeep Singh Sarin, Chidambaram Venkateswaran Srinivasan, Lalit Wadhwa filed Critical Ind Swift Lab Ltd
Publication of WO2008072257A2 publication Critical patent/WO2008072257A2/en
Publication of WO2008072257A3 publication Critical patent/WO2008072257A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/35—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel process for the preparation of indole derivatives. In particular, present invention relates to the process for preparing naratriptan of formula (I), and its salts using novel intermediates. The present invention also relates to novel synthetic intermediates useful in the preparation of naratriptan hydrochloride.
PCT/IN2007/000571 2006-12-12 2007-12-10 Process for the preparation of indole derivatives WO2008072257A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2660/DEL/2006 2006-12-12
IN2660DE2006 2006-12-12

Publications (2)

Publication Number Publication Date
WO2008072257A2 WO2008072257A2 (en) 2008-06-19
WO2008072257A3 true WO2008072257A3 (en) 2009-04-09

Family

ID=39512189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000571 WO2008072257A2 (en) 2006-12-12 2007-12-10 Process for the preparation of indole derivatives

Country Status (1)

Country Link
WO (1) WO2008072257A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009118753A2 (en) * 2008-03-07 2009-10-01 Usv Limited Process for preparation of naratriptan hydrochloride
AU2010284832A1 (en) 2009-08-20 2012-02-09 Cipla Limited A process for the synthesis of naratriptan
CN103408491B (en) * 2013-08-22 2015-09-30 通化茂祥制药有限公司 7-chloro-4-oxo-quinoline preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997841A (en) * 1987-08-13 1991-03-05 Glaxo Group Limited Indole derivatives
US5066660A (en) * 1987-08-13 1991-11-19 Glaxo Group Limited Indole derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997841A (en) * 1987-08-13 1991-03-05 Glaxo Group Limited Indole derivatives
US5066660A (en) * 1987-08-13 1991-11-19 Glaxo Group Limited Indole derivatives

Also Published As

Publication number Publication date
WO2008072257A2 (en) 2008-06-19

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