WO2010091523A1 - Dispositif d'administration présentant un indicateur de distribution - Google Patents

Dispositif d'administration présentant un indicateur de distribution Download PDF

Info

Publication number
WO2010091523A1
WO2010091523A1 PCT/CH2010/000019 CH2010000019W WO2010091523A1 WO 2010091523 A1 WO2010091523 A1 WO 2010091523A1 CH 2010000019 W CH2010000019 W CH 2010000019W WO 2010091523 A1 WO2010091523 A1 WO 2010091523A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid product
signal generator
administering
housing
signal
Prior art date
Application number
PCT/CH2010/000019
Other languages
German (de)
English (en)
Inventor
Jürgen Wittmann
Peter Stettler
Aurele Horisberger
Patrick Hostettler
Stefan Meier
Malte Kladiwa
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Publication of WO2010091523A1 publication Critical patent/WO2010091523A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback

Definitions

  • the present invention relates to an administering device for administering a fluid product having a dispensing indicator which indicates the end of administration of a dose amount of the fluid product.
  • a delivery device for administering a fluid product is for subcutaneous administration of a medical, pharmaceutical or cosmetic fluid product.
  • the fluid product is generally received in a product container stored in the delivery device.
  • Various administration devices are known in the art, such as a disposable injector disposed of after the product container has been completely emptied, a reusable injector in which a deflated product container is replaceable by a filled product container, or an auto-injector. which is suitable for automatically piercing an injection needle into the tissue and then automatically dispensing a product dose.
  • a dispensing device which acts to dispense the fluid product from the product container onto the fluid product.
  • a drive rod is provided which is displaceable for dispensing relative to a housing of the administering device and advances a plug in the product container, so that the product can be dispensed from the product container through an attached injection needle.
  • a dispensing movement be stopped and the delivery device be removed from the tissue.
  • various signal generating means are known in an administering device which generate a signal once a dose distribution has been completed.
  • the signal is generated mechanically by a component of the dispensing device at the end of the payout pushes against a stop and thereby generates, for example, a clicking noise.
  • a flexible locking element which is moved in the distribution, jumps from a deflected in the distribution state at the end of the payout in a latching engagement and thereby generates a noise.
  • signal generators in the form of a metal plate are known, which generate a cracking noise when bending from one position to another, as is known, for example, from crackpot frogs.
  • An apparatus for administering a fluid product comprises a discharge device for discharging the fluid product from a product container having a discharge member and a discharge drive for driving the discharge member. Further, a signal generator for generating a signal after completion of a discharge of a predetermined dose amount of the fluid product is provided. Preferably, an acoustic signal is generated by the signal generator. According to the invention, a drive device is provided for driving the signal generator for generating a signal, which is independent of the output drive.
  • a dispenser for dispensing the fluid product may serve, for example, a rack and pinion mechanism, wherein the Aus thoroughlyglied is formed by a rack which is advanced by pressing a protruding from a housing of the administering dispensing button and thus acts on the fluid product in the product container.
  • the discharge drive is designed manually in this case.
  • the Aus superglied may also include a threaded rod as Aus thoroughlyglied which is driven by a rotary drive in the direction of the product container relative to the housing. This drive can also be designed manually.
  • Such a dispensing drive is provided, for example, in auto-injectors or in automatic dispensing delivery devices.
  • the dispensing drive acts on the dispensing member in such a way that it is driven relative to the housing of the administering device and a dispensing takes place from the product container.
  • the Aus thoroughlyglied act, for example, on a arranged in the product container product plug and advance it in the product container, so that the fluid product, eg. B. is released by a hypodermic needle.
  • the administering device may comprise a metering device with which a desired predetermined dose amount can be set.
  • the dose device z. B. a dose setting, which is moved relative to the housing according to a dose to be administered by the user and with the Aus/weg the Ausfact listening can be adjusted.
  • the dose setting element is moved from a starting position to an inflated position relative to the housing.
  • the starting position may, for. B. be determined by a zero dose position in which no dose amount is set.
  • the Doseinstellelement may be a rotary sleeve which is rotatably mounted in the housing or can be unscrewed from the housing. It is also conceivable dose setting with an axial adjustment movement on a dose setting.
  • the metering device may include a dose indicator from which a set dose amount can be read. It is advantageous if the dose display is moved back to the starting position simultaneously with the distribution of the set dose.
  • the dose indicator may be provided on the dose setting element or may be formed by a separate component.
  • the dose indicator can be formed by a rotatably mounted in the housing rotary or threaded sleeve. In a simple execution of the metering device, the same dose amount is set in each case, z. Example, when in the application of the fluid product always the same amounts of the fluid product are required.
  • the signal generator for the signal after completion of a discharge of a predetermined dose amount of the fluid product may be formed mechanically or electrically.
  • the signal generator can strike against a signal stop, so that an acoustic signal is generated by the stop. Depending on the materials used, this can be, for example, a kind of clicking noise.
  • the drive means for driving the signal generator for generating the signal from the Aus wellantrieb is independent. If the device for administering the fluid product also has a metering device for setting a dose quantity to be delivered with a metering drive, the drive device for driving the signal generator is also independent of the metering drive.
  • the signal generator thus has its own drive, which can be targeted to the requirements of the signal generation. The driving force and the driving direction for generating the signal is therefore not dependent on the requirements for a discharge or a dosage of the fluid product.
  • a trigger member is provided which triggers the drive means after completion of a payout.
  • the signal generator By triggering the drive means, the signal generator is moved relative to the housing of the delivery device and can indicate the completion of the distribution of the predetermined dose amount.
  • the drive device for driving the signal generator is independent of a delivery drive or a metering drive, a signal generator according to the invention can be provided in administration devices with different types of drive or metering mechanism. It is not necessary in the design of the drive or metering additionally to pay attention to the integration of the signal generator.
  • the drive means comprises, for example, a spring element, such as a cylindrical coil spring or a coil spring, which can exert a force on the signal generator. However, it can also be provided another spring element, such as an elastically deflectable plastic strap.
  • Such a bracket may for example be molded onto an already existing component of the administering device. Further, it is possible to use as an elastic rubber member.
  • the spring element is preferably provided between a housing-fixed component and the signal generator. When the spring force is triggered, the signal generator is moved relative to the housing and can strike against the signal stop.
  • a tensioning device for tensioning the drive means for the signal generator against the force of the spring member from an initial position to a cocked position.
  • an actuating member may be provided, which is actuated against the force of the spring element and this brings from an initial position to a cocked position.
  • the actuating member can act on the signal generator and move it substantially counter to the direction which leads to a signal generation. If the spring element is provided between a housing-fixed component and the signal generator, the spring element is tensioned by this movement.
  • a locking device may be provided which locks the drive device in the cocked position.
  • the latching device for example, a locking piece on the signal generator and a counter-locking piece on the housing or a housing-fixed component.
  • the latching device is designed such that the signal generator automatically locked in a movement against the spring force in the cocked position of the drive means by the latching piece and the locking counterpart engage or engage one behind the other and prevent a feed of the signal generator by the tensioned spring.
  • the operating member for tensioning the tensioning device may for example be provided by an actuator of the dispensing device to activate the dispensing drive, or to trigger a discharge of the fluid product.
  • the actuator may, for example, be a push-button which is pressed into the housing of the administering device for actuating the discharge.
  • the actuator may also be a slider on the outer circumference of the housing, which is displaced relative to the housing.
  • the actuator may also be provided for actuating a metering device for setting a dose amount to be distributed.
  • a metering device for setting a dose amount to be distributed.
  • the metering device can have, for example, a dose indicator, such as a display sleeve, from which the currently set dose can be read.
  • the drive means for the signal generator After the drive means for the signal generator has been brought by the operation of the actuator by means of the clamping device in a cocked position and locked there by the latching means, the drive means for driving the signal generator is released by a trigger member from the cocked position. That is, the signal generator is released by the trigger member from the catch. By triggering, the spring force can act on the signal generator and drive it relative to the housing. As soon as the signal generator hits the signal stop, a signal is generated.
  • a trigger member an element of the dispensing and / or metering mechanism is preferably used.
  • the trigger member may be provided by a dose indicator member which is moved from the position of a set dose to a zero dose position during the dose distribution.
  • the dose indicator Once the dose indicator has reached the zero dose position, it triggers the drive means of the signal generator, that is, raises the signal generator out of lock, producing a signal indicating the end of the payout. Independently, the end of the distribution can be indicated by the zero-dose indication on the dose indicator. Since the dose indicator in the distribution of the display of the set dose size Returned simultaneously with the payout, except for the zero dose indication, the payout is completed on this display.
  • the trigger member may also be provided by an element of the dispenser, such as the dispenser, which acts on the fluid product in the product container.
  • the dispenser may trigger the drive means to drive the signal generator, thereby delivering a signal at the end of the dispensing.
  • FIG. 1 shows a partial sectional view of an administration device according to the present invention in a start position
  • FIG. 2 administration device according to FIG. 1 in a latching position
  • FIG. 3 administering device according to FIG. 1 in a dispensing position
  • FIG. 4 shows the administration device according to FIG. 1 in a release position
  • FIG. 5 administration device according to FIG. 1 in a signal position
  • FIG. 6 Administration device according to FIG. 1 in an end position.
  • FIG. 1 shows the proximal region of a device for administering a fluid product in which a dispensing device and a dosing device are accommodated.
  • a product container is accommodated which contains the fluid product and to which an injection needle unit adjoins.
  • the distal region with the product container and the injection needle unit corresponds to conventional designs of the prior art, such as in WO 2008/031235 Al and is therefore not explained here.
  • the disclosure from WO 2008/031235 A1 with regard to the arrangement of an injection needle, a product container, a dispensing device, a dispensing device on, or in the administration device and its modes of operation is hereby incorporated in full in the description of the present invention.
  • the proximal portion of the delivery device with the dispensing and metering device may be part of a disposable injector or a reusable injector.
  • Fig. 1 there is shown a sleeve-like housing 1 and an actuating member projecting from the housing in the form of a push-button 2 which serves to trigger a release of the fluid product from the administering device.
  • the push button 2 can be inserted axially along the longitudinal direction into the housing 1.
  • a dosing and display sleeve 3 is shown in a partial section and mounted in the housing 1 by a threaded connection 4.
  • the metering and display sleeve 3 is rotatable relative to the housing for setting a dosage amount to be administered, wherein an axial displacement of the sleeve 3 is effected by the threaded connection.
  • the sleeve 3 in the interior of the housing 1 is driven by means of the rotary sleeve 5, which adjoins the housing in the longitudinal direction and is partially disposed over the housing. Details regarding the dose setting and product release can also be found in WO 2008/031235 A1, which is hereby incorporated by reference is taken.
  • the press button 2 is adjoined by an axially aligned web 2a, which has a protruding projection 2b in its distal region.
  • the web 2a protrudes into the interior of the housing 1.
  • a disk or bar-like signal generator 6 is provided in the circumferential direction next to the web 2a of the push button 2.
  • the signal generator 6 is movably mounted relative to the housing 1 in the axial direction. It can be performed, for example, in a guide on the inner circumference of the housing sleeve.
  • the Signal generator 6 has a circumferentially oriented projection 6a and an adjoining obliquely to the longitudinal axis extending ramp 6b.
  • a locking piece 6c In the circumferential direction on the projection 6a opposite edge of a locking piece 6c is provided, which is formed like a hook. The side of this flank is followed by a radially inwardly projecting housing edge 7, which extends in the longitudinal direction and in its distal region has a counter-locking piece 7a, which may be formed for example as an incision in the edge. Between the signal generator 6 and a circumferentially extending radially inwardly projecting edge of the housing 1, a spring 8 is arranged as a drive device for the signal generator 6.
  • the signal generator 6 is shown in a start position.
  • the spring 8 is in an untensioned state.
  • the signal generator 6 rests with its proximal edge on a radially inwardly projecting projection Ia of the housing.
  • the locking piece 6c of the signal generator 6 bears laterally against the housing edge 7.
  • the projection 2b of the web 2a abuts in the axial direction on its distal side to the projection 6a of the signal generator 6.
  • the push button 2 is in a position extended longitudinally out of the housing.
  • the metering and display sleeve 3 is located relative to the housing 1 in a proximal position corresponding to a zero dose setting.
  • the zero-dose display can be read from the sleeve 3, for example, by a window in the housing, not visible in the figure.
  • the metering and display sleeve 3 is rotated relative to the housing 1, as can be seen in FIG. As soon as a discharge by a Aus part worn inside the sleeve 3 (not visible), at the same time the metering and display sleeve 3 is rotated in the proximal direction back to the starting position, as will be explained in more detail below ,
  • the signal generator 6 has been tensioned by means of a clamping device against the force of the spring and is shown in a detent position.
  • the push button 2 as an actuator for the clamping device was pressed to initiate a discharge of the fluid product by means of the Aus super
  • the projection 2b acts as a driver on the signal generator and moves it in the clamping direction with.
  • the spring 8 between the housing 1 and the signal generator 6 is tensioned.
  • the signal generator 6 is displaced until the locking piece 6c snaps into a latching engagement with the counter-locking piece 7a, as can be seen in FIG. A further axial displacement of the signal generator 6 is not possible, since the movement is blocked by the stop of the spring 8 or on the housing projection.
  • the tensioning device for the drive device in the form of the spring of the signal generator 6 is in Figure 2 in a cocked position.
  • the locking piece 6c and the counter-locking piece 7a form a latching device which holds the clamping device in the cocked position.
  • the push button 2 serves as an actuator for clamping the clamping device.
  • the signal generator 6 leads through the latching device of the locking pieces 6c and 7a in the prestressed position.
  • the administering device is shown in a dispensing position, in which by the push button 2 a discharge is triggered by the Ausfact heard.
  • the push button 2 is completely pressed into the housing 1 via a second section B (see FIG. 2).
  • the signal generator 6 can not be moved by the movement of the web 2a, since it abuts on the housing 8 via the spring.
  • the projection 2b of the web 2a slides on further pressing the push button 2 on the projection 6a of the signal generator.
  • the signal generator 6 is shown in a triggering position. Due to the mechanism of the dispensing and metering device, the metering and display sleeve 3 is moved by means of the thread 4 in the proximal direction during the distribution.
  • the sleeve 3 has at its proximal end an axially extending stop edge 3 a, which moves during the dispensing movement and thus during the proximal movement of the sleeve 3 in the direction of the signal generator 6.
  • the sleeve 3 bears against a housing edge extending in the axial direction on the inner circumference of the housing 1, so that the discharge is terminated.
  • the signal generator 6 is shown in a signal position.
  • the signal generator 6 has been displaced by the drive of the spring 8 relative to the housing and struck on the housing projection Ia generating a noise.
  • the time between the stop of the sleeve 3 at the inner edge of the housing and the associated termination of the discharge and the advance of the signal generator 6 to the stop on the housing projection Ia is negligible.
  • a warning signal sounds immediately upon the termination of the payout.
  • FIG. 6 shows the administering device in an end position after a successful administration, which substantially corresponds to the sucking position according to FIG.
  • the push button 2 was pushed out of the housing 1 in the proximal direction by a spring element.
  • the web 2a is moved in the axial direction relative to the signal generator 6.
  • the projection 2b of the web 2a slides on the ramp 6b of the signal generator 6 and is thereby lifted over the projection 6a of the signal generator 6.
  • the delivery device is now in its starting position and can be used for a new distribution.

Abstract

L'invention concerne un dispositif d'administration d'un produit fluide présentant un dispositif de déversement pour la distribution du produit fluide à partir d'un récipient de produit, présentant un élément distributeur et une commande servant à l'activation de l'élément distributeur. Il est prévu un générateur de signal (6) pour la production d'un signal une fois qu'une quantité dosée prédéterminée du produit fluide s'est déversée du récipient de produit. Un dispositif de commande (8) servant à la commande du générateur de signal (6) pour la production d'un signal, est configuré indépendamment de la commande du déversement.
PCT/CH2010/000019 2009-02-12 2010-01-26 Dispositif d'administration présentant un indicateur de distribution WO2010091523A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH213/09 2009-02-12
CH00213/09A CH700404A1 (de) 2009-02-12 2009-02-12 Verabreichungsvorrichtung mit Ausschüttanzeige.

Publications (1)

Publication Number Publication Date
WO2010091523A1 true WO2010091523A1 (fr) 2010-08-19

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Application Number Title Priority Date Filing Date
PCT/CH2010/000019 WO2010091523A1 (fr) 2009-02-12 2010-01-26 Dispositif d'administration présentant un indicateur de distribution

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CH (1) CH700404A1 (fr)
WO (1) WO2010091523A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508606A (ja) * 2011-03-02 2014-04-10 オウエン マンフォード リミティド 注射装置
CN105246530A (zh) * 2013-06-04 2016-01-13 诺和诺德股份有限公司 具有剂量终结机构的扭力弹簧注射装置

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012032411A2 (fr) * 2010-09-07 2012-03-15 Tecpharma Licensing Ag Dispositif d'injection automatique
EP2692377B1 (fr) * 2012-08-01 2019-11-06 TecPharma Licensing AG Dispositif d'injection avec élément d'affichage de dose pour signaler fin d'injection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819409A1 (de) * 1998-04-30 1999-11-11 Schering Ag Injektionsvorrichtung
WO2008031235A1 (fr) 2006-09-15 2008-03-20 Tecpharma Licensing Ag Appareil d'injection à entraînement à faibles pertes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819409A1 (de) * 1998-04-30 1999-11-11 Schering Ag Injektionsvorrichtung
WO2008031235A1 (fr) 2006-09-15 2008-03-20 Tecpharma Licensing Ag Appareil d'injection à entraînement à faibles pertes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014508606A (ja) * 2011-03-02 2014-04-10 オウエン マンフォード リミティド 注射装置
CN105246530A (zh) * 2013-06-04 2016-01-13 诺和诺德股份有限公司 具有剂量终结机构的扭力弹簧注射装置
CN105246530B (zh) * 2013-06-04 2019-07-26 诺和诺德股份有限公司 具有剂量终结机构的扭力弹簧注射装置

Also Published As

Publication number Publication date
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