WO2010089773A3 - Process for preparation of nitropyridine derivatives - Google Patents

Process for preparation of nitropyridine derivatives Download PDF

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Publication number
WO2010089773A3
WO2010089773A3 PCT/IN2010/000055 IN2010000055W WO2010089773A3 WO 2010089773 A3 WO2010089773 A3 WO 2010089773A3 IN 2010000055 W IN2010000055 W IN 2010000055W WO 2010089773 A3 WO2010089773 A3 WO 2010089773A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
preparation
carbon atoms
halogen atom
amino
Prior art date
Application number
PCT/IN2010/000055
Other languages
French (fr)
Other versions
WO2010089773A2 (en
Inventor
Ketan Dhansukhlal Vyas
Ranjeet Nair
Vidyadhar Kashinath Jadhav
Nikunj Bhatt
Sandip Kacharu Deshmukh
Prakash Popat Pansare
Rajesh Kumar Singh
Aditi Milind Panandikar
Original Assignee
Indoco Remedies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indoco Remedies Limited filed Critical Indoco Remedies Limited
Priority to JP2011547064A priority Critical patent/JP2012516843A/en
Publication of WO2010089773A2 publication Critical patent/WO2010089773A2/en
Publication of WO2010089773A3 publication Critical patent/WO2010089773A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed here is a process for the preparation of nitropyridine derivatives of Formula (I) and its salt and precursors such as halogenated amino pyridines; Wherein; R1 is selected from amino group, hydroxyl group, acyl group, alkyl amino group, halogen atom, -NH - C (O) - R3; Where R3 is branched or linear alkyl group having 1 - 6 carbon atoms, or cycloalkyl group having 3 - 6 carbon atoms; R2 is selected from hydroxyl group, halogen atom, alkoxy group.
PCT/IN2010/000055 2009-02-02 2010-02-02 Process for preparation of nitropyridine derivatives WO2010089773A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011547064A JP2012516843A (en) 2009-02-02 2010-02-02 Method for preparing nitropyridine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202MU2009 2009-02-02
IN202/MUM2009 2009-02-02

Publications (2)

Publication Number Publication Date
WO2010089773A2 WO2010089773A2 (en) 2010-08-12
WO2010089773A3 true WO2010089773A3 (en) 2010-10-21

Family

ID=42341624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000055 WO2010089773A2 (en) 2009-02-02 2010-02-02 Process for preparation of nitropyridine derivatives

Country Status (2)

Country Link
JP (1) JP2012516843A (en)
WO (1) WO2010089773A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102584688B (en) * 2012-01-13 2014-07-23 江苏中邦制药有限公司 Preparing method of 2,6-dichloro-3-nitropyridine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307054B1 (en) * 1996-01-02 2001-10-23 Aventis Pharmaceuticals Products Inc. Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine
WO2007040438A2 (en) * 2005-10-03 2007-04-12 Astrazeneca Ab Novel imidazo [4,5 -b] pyridine derivatives as inhibitors of glycogen synthase kinase 3 for use in the treatment of dementia and neurodegenerative disorders
WO2007059202A2 (en) * 2005-11-15 2007-05-24 Bayer Healthcare Ag Pyrazolyl urea derivatives useful in the treatment of cancer
WO2008099021A1 (en) * 2007-02-16 2008-08-21 Tibotec Pharmaceuticals Ltd. Dibenzodiazepinones useful as hepatitis c virus inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225131A1 (en) 2002-04-05 2003-12-04 Burgey Christopher S. Thrombin inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307054B1 (en) * 1996-01-02 2001-10-23 Aventis Pharmaceuticals Products Inc. Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine
WO2007040438A2 (en) * 2005-10-03 2007-04-12 Astrazeneca Ab Novel imidazo [4,5 -b] pyridine derivatives as inhibitors of glycogen synthase kinase 3 for use in the treatment of dementia and neurodegenerative disorders
WO2007059202A2 (en) * 2005-11-15 2007-05-24 Bayer Healthcare Ag Pyrazolyl urea derivatives useful in the treatment of cancer
WO2008099021A1 (en) * 2007-02-16 2008-08-21 Tibotec Pharmaceuticals Ltd. Dibenzodiazepinones useful as hepatitis c virus inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARVANITIS, A., G. ET AL.: "Imidazo[4,5-b]pyridines as Corticotropin Releasing Factor Receptor Ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, PERGAMON, ELSEVIER SCIENCE; GB, pages 125 - 128, XP002597030, ISSN: 0960-894X *
DENG, J., Z. ET AL.: "Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, PERGAMON, ELSEVIER SCIENCE; GB, pages 4411 - 4416, XP025313952, ISSN: 0960-894X, [retrieved on 20051015] *

Also Published As

Publication number Publication date
WO2010089773A2 (en) 2010-08-12
JP2012516843A (en) 2012-07-26

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