IN2014CN00532A - - Google Patents
Info
- Publication number
- IN2014CN00532A IN2014CN00532A IN532CHN2014A IN2014CN00532A IN 2014CN00532 A IN2014CN00532 A IN 2014CN00532A IN 532CHN2014 A IN532CHN2014 A IN 532CHN2014A IN 2014CN00532 A IN2014CN00532 A IN 2014CN00532A
- Authority
- IN
- India
- Prior art keywords
- production method
- synthetic intermediate
- hiv agent
- provides
- present
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 abstract 5
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 3
- 229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 4-OXOQUINOLINE COMPOUND Chemical class 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010061833 Integrases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ABSTRACT METHOD FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of' an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, foi example, compounds represented by the formulas (6), (7-1), (7-2) and (8):wherein R is a fluorine atom or a methoxy group, R1 is a Ci - C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006060274 | 2006-03-06 | ||
JP2006060297 | 2006-03-06 | ||
PCT/JP2007/054311 WO2007102499A1 (en) | 2006-03-06 | 2007-03-06 | Process for production of 4-oxoquinoline compound |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN00532A true IN2014CN00532A (en) | 2015-04-03 |
Family
ID=38474927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN532CHN2014 IN2014CN00532A (en) | 2006-03-06 | 2007-03-06 |
Country Status (4)
Country | Link |
---|---|
US (2) | US8420821B2 (en) |
CN (1) | CN101437801B (en) |
IN (1) | IN2014CN00532A (en) |
WO (1) | WO2007102499A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK2662004A3 (en) | 2002-11-20 | 2005-06-02 | Japan Tobacco, Inc. | 4-Oxoquinoline compound and its utilisation as integrase inhibitor |
AP2914A (en) | 2006-03-06 | 2014-05-31 | Japan Tobacco Inc | Method for producing 4-oxoquinoline compound |
WO2008033836A2 (en) | 2006-09-12 | 2008-03-20 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
AR068403A1 (en) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | PROCESS AND INTERMEDIARIES FOR THE PREPARATION OF INTEGRASA INHIBITORS |
WO2011004389A2 (en) * | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
JP5868324B2 (en) * | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | Asymmetric auxiliary group |
EP2880017B1 (en) | 2012-08-03 | 2016-10-05 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
CZ304983B6 (en) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Preparation process and novel intermediates of elvitegravir synthesis |
CZ304984B6 (en) | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Enhanced process for preparing and novel intermediates of elvitegravir synthesis |
DK3067358T3 (en) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | POLYCYCLIC CARBAMOYLPYRIDON COMPOUNDS AND THEIR PHARMACEUTICAL USE |
CZ307255B6 (en) * | 2013-07-11 | 2018-05-02 | Zentiva, K.S. | A new method of preparing elvitegravir |
PT3019503T (en) | 2013-07-12 | 2017-11-27 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections |
NO2865735T3 (en) | 2013-07-12 | 2018-07-21 | ||
CN105315203A (en) * | 2014-06-06 | 2016-02-10 | 上海迪赛诺化学制药有限公司 | V-type elvitegravir crystal and preparation method thereof |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
TWI744723B (en) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | Synthesis of polycyclic-carbamoylpyridone compounds |
NO2717902T3 (en) | 2014-06-20 | 2018-06-23 | ||
TWI738321B (en) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
KR20190057158A (en) | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
CN111051281A (en) | 2017-06-21 | 2020-04-21 | 波涛生命科学有限公司 | Compounds, compositions and methods for synthesis |
JP7472018B2 (en) | 2017-09-18 | 2024-04-22 | ウェーブ ライフ サイエンシーズ リミテッド | Techniques for preparing oligonucleotides |
CN112661698A (en) * | 2021-01-14 | 2021-04-16 | 浙江海森药业股份有限公司 | Preparation method of elvitegravir |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3472859A (en) * | 1966-11-01 | 1969-10-14 | Sterling Drug Inc | 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters |
DE3501247A1 (en) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | AMINO ACRYLIC ACID DERIVATIVES |
US5591744A (en) | 1987-04-16 | 1997-01-07 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
NO885426L (en) | 1987-12-11 | 1989-06-12 | Dainippon Pharmaceutical Co | QUINOLINE DERIVATIVES, AND PROCEDURES FOR PREPARING THEREOF. |
US4920120A (en) | 1988-01-25 | 1990-04-24 | Warner-Lambert Company | Antibacterial agents |
DE3934082A1 (en) * | 1989-10-12 | 1991-04-18 | Bayer Ag | CHINOLON CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AN ANTIVIRAL AGENT |
DE4015299A1 (en) | 1990-05-12 | 1991-11-14 | Bayer Ag | METHOD FOR PRODUCING 3-AMINO-2- (HET) -AROYL-ACRYLIC ACID DERIVATIVES |
US5686482A (en) * | 1994-04-28 | 1997-11-11 | Yamanouchi Pharmaceutical Co., Ltd. | N-(3-pyrrolidinyl) benzamide derivative |
US5989451A (en) * | 1997-02-07 | 1999-11-23 | Queen's University At Kingston | Compounds and methods for doping liquid crystal hosts |
JPH1184556A (en) | 1997-09-08 | 1999-03-26 | Konica Corp | Silver halide emulsion, photosensitive material processing method using the same and photographic method |
GB9807903D0 (en) | 1998-04-14 | 1998-06-10 | Smithkline Beecham Plc | Novel compounds |
US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
PE20011349A1 (en) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-ARIL-4-OXO-1,4-DIHYDRO-3-QUINOLINE CARBOXAMIDES AS ANTIVIRAL AGENTS |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
WO2002048113A1 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Cyclization process step in the making of quinolones and naphthyridines |
TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
SK2662004A3 (en) * | 2002-11-20 | 2005-06-02 | Japan Tobacco, Inc. | 4-Oxoquinoline compound and its utilisation as integrase inhibitor |
MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
AP2914A (en) * | 2006-03-06 | 2014-05-31 | Japan Tobacco Inc | Method for producing 4-oxoquinoline compound |
WO2008033836A2 (en) * | 2006-09-12 | 2008-03-20 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
AR068403A1 (en) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | PROCESS AND INTERMEDIARIES FOR THE PREPARATION OF INTEGRASA INHIBITORS |
-
2007
- 2007-03-06 WO PCT/JP2007/054311 patent/WO2007102499A1/en active Application Filing
- 2007-03-06 US US12/281,921 patent/US8420821B2/en active Active
- 2007-03-06 IN IN532CHN2014 patent/IN2014CN00532A/en unknown
- 2007-03-06 CN CN2007800161514A patent/CN101437801B/en active Active
-
2013
- 2013-01-14 US US13/741,214 patent/US20130345462A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101437801A (en) | 2009-05-20 |
US8420821B2 (en) | 2013-04-16 |
US20130345462A1 (en) | 2013-12-26 |
US20090318702A1 (en) | 2009-12-24 |
CN101437801B (en) | 2013-02-06 |
WO2007102499A1 (en) | 2007-09-13 |
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