WO2010070593A3 - Esters de malonate - Google Patents
Esters de malonate Download PDFInfo
- Publication number
- WO2010070593A3 WO2010070593A3 PCT/IB2009/055786 IB2009055786W WO2010070593A3 WO 2010070593 A3 WO2010070593 A3 WO 2010070593A3 IB 2009055786 W IB2009055786 W IB 2009055786W WO 2010070593 A3 WO2010070593 A3 WO 2010070593A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- aryl
- malonate esters
- enantiomerically enriched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
La présente invention concerne un composé de formule (I) sous une forme énantiomériquement enrichie. Dans ladite formule, R1 et R2 sont chacun indépendamment sélectionnés parmi un alkyle éventuellement substitué, un cycloalkyle, un aryle-alkyle et un aryle, le 3S-énantiomère étant présent en excès et l'excès énantiomérique étant au moins égal à 10 %. L'invention concerne également un procédé de préparation, sous une forme énantiomériquement enrichie, du composé de formule (I). L'invention concerne en outre un composé de formule (I) dans un procédé de préparation de prégabaline.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE2008/1008 | 2008-12-19 | ||
IE20081008 | 2008-12-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010070593A2 WO2010070593A2 (fr) | 2010-06-24 |
WO2010070593A3 true WO2010070593A3 (fr) | 2010-11-04 |
Family
ID=42169662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2009/055786 WO2010070593A2 (fr) | 2008-12-19 | 2009-12-16 | Esters de malonate |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010070593A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012025861A1 (fr) | 2010-08-23 | 2012-03-01 | Pfizer Manufacturing Ireland | Procédé de préparation de dérivés d'acide (s)-3-cyano-5-méthylhexanoïque et de prégabaline |
DE112016001317T5 (de) * | 2015-03-20 | 2018-01-04 | Stanford University | Carbonat-unterstützte Carboxylierungsreaktion zur Synthese wertvoller organischer Verbindungen |
WO2017183539A1 (fr) * | 2016-04-18 | 2017-10-26 | 第一三共株式会社 | Procédé de production d'un composé bicyclique à l'aide d'acide de meldrum |
CN109232311B (zh) * | 2018-10-08 | 2021-02-19 | 浙江新和成股份有限公司 | 一种绿色高效的普瑞巴林合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050283023A1 (en) * | 2004-06-21 | 2005-12-22 | Shanghui Hu | Preparation of pregabalin and related compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3823864A1 (de) | 1988-01-29 | 1989-08-10 | Kernforschungsanlage Juelich | Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen |
US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
US5616793A (en) | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5637767A (en) | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
DE60102356T2 (de) | 2000-01-27 | 2005-02-17 | Warner-Lambert Co. | Asymmetrische synthese von pregabalin |
-
2009
- 2009-12-16 WO PCT/IB2009/055786 patent/WO2010070593A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050283023A1 (en) * | 2004-06-21 | 2005-12-22 | Shanghui Hu | Preparation of pregabalin and related compounds |
WO2006000904A2 (fr) * | 2004-06-21 | 2006-01-05 | Warner-Lambert Company Llc | Preparation de composes associes a la pregabaline |
Also Published As
Publication number | Publication date |
---|---|
WO2010070593A2 (fr) | 2010-06-24 |
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