WO2010061697A1 - Gene sensitive to normal-tension glaucoma disease, and use thereof - Google Patents

Gene sensitive to normal-tension glaucoma disease, and use thereof Download PDF

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Publication number
WO2010061697A1
WO2010061697A1 PCT/JP2009/068098 JP2009068098W WO2010061697A1 WO 2010061697 A1 WO2010061697 A1 WO 2010061697A1 JP 2009068098 W JP2009068098 W JP 2009068098W WO 2010061697 A1 WO2010061697 A1 WO 2010061697A1
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human chromosome
region containing
region
single nucleotide
nucleotide polymorphism
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PCT/JP2009/068098
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French (fr)
Japanese (ja)
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信久 水木
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株式会社メニコン
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Priority to CN2009801472986A priority Critical patent/CN102224244A/en
Publication of WO2010061697A1 publication Critical patent/WO2010061697A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91051—Acyltransferases other than aminoacyltransferases (general) (2.3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/168—Glaucoma

Definitions

  • the present invention relates to a normal pressure glaucoma disease susceptibility gene and use thereof.
  • Glaucoma is a progressive refractory disease that causes damage to the optic nerve due to an increase in intraocular pressure that exceeds normal ocular pressure that can maintain normal visual function. If left untreated, the visual field stenosis may progress and cause blindness. Although it is currently the leading cause of blindness in Japan, the cause is unknown and accurate diagnosis and effective treatment are available. And there is no prevention.
  • normal-tension glaucoma NSG
  • NVG normal-tension glaucoma
  • NTG has a normal range of intraocular pressure, so it is difficult to detect by intraocular pressure test, and is often overlooked in health examinations and normal ophthalmic examinations. Since optic nerve damage does not recover, early detection and treatment are the most important in NTG. However, the progression is slow, and the central visual field is damaged late, so that subjective symptoms are poor, and the optic nerve injury progresses without the user's knowledge.
  • Non-patent Documents 1-15 Myocilin
  • optineurin Non-patent Documents 16-30
  • optic atrophy 1 Non-patent Documents 31-41
  • An object of the present invention is to find a normal-tension glaucoma disease susceptibility gene and provide a method for using the gene.
  • the gist of the present invention is as follows.
  • the polymorphic site in the region containing ELOVL5 of human chromosome 6 is a single nucleotide polymorphism international number rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730, rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs
  • rs2287929 and rs16896325 are selected from the group consisting of rs2287929 and rs16896325, and NCBI (v36.1) 65944399, Polymorphic sites in the region containing GLRX and / or C5orf27 of human chromosome 5 are single nucleotide polymorphism international numbers rs34896, rs34897, rs3777220, rs3777217, rs11738579, rs3777213, rs7736948, rs6556883, rs9314160, rs6876015, rs11135436, rs17085165, rs17085170 Rs10040697, rs6884979, rs7702848, rs2080947, rs10476660, rs154454, rs147295, rs17085249, rs11741590, rs37
  • Polymorphic sites in the region containing ANGPT1 of human chromosome 8 are single nucleotide polymorphism international numbers rs12549261, rs10955436, rs6981257, rs11774921, rs11781710, rs1954724, rs6997025, rs1892764, rs16875775, rs11778352, rs2584372, rs2246255, rs2022958, rs2022949, rs168759 Rs1010824, rs2507799, rs10505100, rs11777978, rs16875983, rs9297393, rs7009229, rs13257393, rs4077322, rs11997995, rs10505105, rs4133396, rs4133395, rs4341141, rs10505107, rs11780324, rs35
  • the polymorphic site in the region containing ELOVL5 of human chromosome 6 is a single nucleotide polymorphism international number rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs2562898, rs735860, rs2057024, rs1570146, rs9463895, rs2235723, rs1346603, rs9474476, rs2294867, rs9349660, rs974323, rs6909592, rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs2095
  • the polymorphic site in the region containing 11p11.2 of human chromosome 11 is a single nucleotide polymorphism international number rs11039112, rs747650, rs1685404, rs11570094, rs11039212, rs4992357, rs11605672, rs10742805, rs12419692, rs4752856, rs3817334, rs4752791, rs17788930, rs2305982, rs6485788, rs7924699 and rs1872167,
  • the polymorphic site in the region containing OR5R1 of human chromosome 11 is the single nucleotide polymorphism international number rs1586004, rs7940239, rs10791979, rs157
  • the polymorphic site in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 consists of the single nucleotide polymorphism international numbers rs482458, rs661928, rs7128888, rs7129014, rs688727, rs12574551, rs17134231, rs12282340, rs10160335 and rs12281880 Selected from the group,
  • the polymorphic site in the region containing 11q23-24 of human chromosome 11 is selected from the group consisting of single nucleotide polymorphism international numbers rs664971, rs17120523 and rs528508
  • the polymorphic site in the region containing TAOK3 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs10850953, rs
  • a reagent for examining normal-tension glaucoma which comprises at least one component selected from the group consisting of the following components (a) and (b):
  • human number A probe capable of hybridizing to a region containing at least one polymorphic site in at least one region selected from the group consisting of a region containing CUX2 of chromosome 2 and a region containing TOM1L1 of human chromosome 17 ( 6)
  • a normal-tension glaucoma test kit comprising the reagent according to (5).
  • a host cell transformed with a vector containing the DNA sequence of the marker gene described in (7) is cultured, and a polypeptide encoded by the DNA sequence of the marker gene described in (7) is collected from the culture.
  • a method for producing a polypeptide is described in detail.
  • the present invention makes it possible to more accurately diagnose normal-tension glaucoma. Patients who have already developed a definitive diagnosis, and can be actively treated. In addition, since the risk rate for the onset is calculated for those who have not yet developed, it is recommended that the test be performed frequently for undeveloped patients with a high risk rate for the onset, leading to early detection.
  • region containing 6th chromosome and ELOVL5 and a healthy person is shown.
  • the horizontal axis shows the position of the gene in the region over 0.5 Mb, and the vertical axis shows the p-value, which is a significant difference index.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame.
  • SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • region containing a candidate gene is shown.
  • the horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference.
  • the position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
  • a gene related to normal-tension glaucoma is a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, and an ARPP of human chromosome 3.
  • human chromosome 4 EPHA5 region human chromosome 6 GMDS region
  • human chromosome 6p21.3 human chromosome 6 SYTL3 A region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, a region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, and PAX7 of human chromosome 1.
  • the present invention includes a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, a region containing ARPP-21 of human chromosome 3, a region containing EPHA5 of human chromosome 4, human chromosome 6
  • the region containing GMDS, the region containing 6p21.3 of human chromosome 6 (including HSPA1B), the region containing SYTL3 of human chromosome 6, the region containing NXPH1 of human chromosome 7, and the LHFPL3 of human chromosome 7 A region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, a region containing PAX7 of human chromosome 1, a region containing PTPRF of human chromosome 1, 1q12- of human chromosome 1 region containing q21.1 (including CHD1L and / or FMO5), region containing 1q21.2-q21.3 of
  • a method for examining normal-tension glaucoma is provided.
  • the polymorphic site only needs to show a significant difference between a normal-tension glaucoma patient and a healthy person, and the p value that is an index of a significant difference between the normal-tension glaucoma patient and a healthy person is smaller. Things are desirable. For example, if the p-value is less than 0.05, it is customarily determined that it is clearly useful biologically. Includes the region containing ELOVL5 of human chromosome 6, the region containing SRBD1 of human chromosome 2, the region containing ARPP-21 of human chromosome 3, the region containing EPHA5 of human chromosome 4, and the GMDS of human chromosome 6.
  • a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, human Region containing GLB1L3 of chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21.1 of human chromosome 1 ( Region containing CHD1L and / or FMO5), region containing 1q21.2-q21.3 of human chromosome 1 (including FDPS and / or ASH1L and / or KCNN3), FAM5B of human chromosome 1 and / or A region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2, and / or Is a region
  • the polymorphic site in the region containing ELOVL5 of human chromosome 6 includes single nucleotide polymorphism international numbers rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730, rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs1429
  • Polymorphic sites in the region containing SRBD1 of human chromosome 2 include single nucleotide polymorphism international numbers rs11686431, rs7580559, rs3908093, rs2343412, rs12623996, rs7573149, rs918810, rs6721199, rs7579209, rs10194925, rs17033378, rs2343466, rs17033398, rs6737172, rs4953226, rs3851333, rs12473388, rs11681887, rs35608719, rs11888802, rs11678872, rs2343468, rs13003019, rs6760244, rs12471726, rs2081297, rs10460504, rs7562458, rs4953230, rs4952763, rs
  • Polymorphic sites in the region containing ARPP-21 of human chromosome 3 include single nucleotide polymorphism international numbers rs1523048, rs1523029, rs12487524, rs1403468, rs872133, rs1523040, rs1523041, rs13069451, rs12629480, rs1357449, rs6801949, rs17033355, rs9873254, rs9839823, rs6794354, rs6794373, rs12637211, rs9855328, rs2037538, rs2037539, rs1523038, rs11718271, rs1608314, rs2197728, rs9311101, rs10490870, rs17033506, rs12634096, rs2359774, rs9860326, rs4678,
  • Polymorphic sites in the region containing EPHA5 of human chromosome 4 include single nucleotide polymorphism international numbers rs371925, rs4241661, rs170654, rs1514271, rs2063419, rs13102419, rs11131589, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs4860651, rs11938753, rs1376417, rs10025570, rs1376416, rs2084682, rs7658065, rs9312144, rs1376412, rs17086181, rs17086185, rs6847413, rs2198103, rs12509018, rs17082122, rs6823779, rs1708
  • Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 include single nucleotide polymorphism international numbers rs2248373, rs2248459, rs2248462, rs2248617, rs3749946, rs2523650, rs2904776, rs2516422, rs2905747, rs9267247, rs2395034 , Rs3095229, rs3131631, rs2516486, rs2734573, rs3115537, rs2516478, rs2071593, rs3219183, rs13215091, rs1799964, rs1052248, rs9348876, rs2857697, rs2736172, rs1046089, rs2255741, rs7603, rs844 Rs707974, rs805268, rs
  • Polymorphic sites in the region containing SYTL3 of human chromosome 6 include single nucleotide polymorphism international numbers rs602698, rs678116, rs649930, rs643677, rs592698, rs675053, rs612557, rs629364, rs627967, rs628203, rs2771425, rs9355655, rs10499309, rs1041566, rs12530454, rs7753885, rs9347236, rs6455585, rs6931414, rs10447366, rs9457403, rs9355246, rs4709219, rs4708797, rs4709226, rs4709235, rs6925091, rs3799195, rs6913912, rs894124, rs6903405, r
  • Polymorphic sites in the region containing NXPH1 of human chromosome 7 include single nucleotide polymorphism international numbers rs3807826, rs7802863, rs3757521, rs3757520, rs3807823, rs1861032, rs17145870, rs7805508, rs6977682, rs3807815, rs1008038, rs3807811, rs11769978, rs3779356, rs3807807, rs3807806, rs7455929, rs6463790, rs4620183, rs12668479, rs17147407, rs11762595, rs12702719, rs17147608, rs12154895, rs17403198, rs16873367, rs42949, rs2349188, rs6463805, rs78
  • polymorphic sites in the region containing LHFPL3 of human chromosome 7 include single nucleotide polymorphism international numbers rs41521, rs2188486, rs977641, rs17389507, rs10274138, rs17136882, rs13234807, rs7794181, rs7787988, rs7787976, rs17331134, rs1557689, rs6465984, rs7798273, rs2188494, rs1468143, rs10953427, rs2214087, rs4730006, rs6952170, rs17137313, rs4727599, rs17137382, rs10228106, rs42181, rs4730010, rs11763758, rs17137711, rs11763095, rs6977743, rs4520098, r
  • Polymorphic sites in the region containing GLB1L3 of human chromosome 11 include single nucleotide polymorphism international numbers rs11223704, rs470713, rs470935, rs641024, rs11606866, rs7131644, rs10894784, rs1031381, rs522134, rs4362160, rs473041, rs498602, rs554874, rs1144225, rs1595895, rs1146192, rs4936229, rs1144219, rs2510356, rs553231, rs512359, rs568044, rs10894798, rs10894799, rs11223765, rs10894800, rs7940114, rs10894801, rs10791357, rs3741100, rs3741098, rs
  • polymorphic sites in the region containing ZNF407 of human chromosome 18 include single nucleotide polymorphism international numbers rs3794941, rs17055278, rs514931, rs494721, rs17055426, rs2896769, rs12717033, rs7227977, rs10871527, rs10514139, rs17832851, rs17055756, rs1473224, rs2628125, rs8085262, rs8089151, rs2628123, rs4891199, rs17055919, rs10514148, rs17055185, rs2404482, rs10514149, rs4337381, rs2959165, rs12456768, rs4891217, rs9945585, rs9961644, rs9961742,
  • Polymorphic sites in the region containing PAX7 of human chromosome 1 include single nucleotide polymorphism international numbers rs3000058, rs2816030, rs16862061, rs2816040, rs2816046, rs4920334, rs4920516, rs4920335, rs2816064, rs6704504, rs1934057, rs2298893, rs2743208, rs2076021, rs2076020, rs2236826, rs2282704, rs2282699, rs624761, rs851123, rs2236817, rs685300, rs2056446, rs2841078, rs4920344, rs6669544, rs4076925, rs6603910, rs11261070, rs7539659, rs11261074,
  • Polymorphic sites in the region containing PTPRF of human chromosome 1 include single nucleotide polymorphism international numbers rs2494997, rs1999674, rs2842180, rs2255632, rs2251804, rs1334973, rs6687571, rs2039528, rs2819341, rs10890251, rs2367617, rs11210864, rs2782641, rs11210871, rs10890257, rs12058744, rs11210879, rs11210886, rs516790, rs641365, rs673485, rs643445, rs10789438, rs11210892, rs617899, rs660899, rs2274465, rs10789439, rs489319, rs607062, rs1078944
  • Polymorphic sites in the region containing 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 include single nucleotide polymorphism international numbers rs2355388, rs6686200rs12122453, rs12122534, rs4950474, rs4950475, rs6593810, rs6657631, rs21327 , Rs517201, rs575115, rs2031481, rs2477568, rs2477569, rs692963, rs535827, rs4950361, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs3, 745 , Rs6703187, rs10793652, rs75
  • polymorphic sites in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1 include single nucleotide polymorphism international numbers rs10752613, rs11583896, rs16835600, rs4434872, rs4567311 , Rs4363451, rs9427232, rs4845576, rs4520447, rs4845578, rs11585416, rs4845584, rs12033835, rs11581644, rs10908557, rs6701341, rs2297898, rs12048137, rs11264875, rs2066134, rs2494663, rs6671166, rs4845600, rs19853 Rs1212352, rs6672010, rs6702754, rs2274988,
  • Polymorphic sites in the region containing PKP1 of human chromosome 1 include single nucleotide polymorphism international numbers rs1122396, rs1722755, rs6413916, rs831771, rs1404401, rs831767, rs16847944, rs831765, rs16847947, rs831764, rs16847951, rs831762, rs8317553, rs16847994, rs831751, rs4915220, rs10157719, rs947379, rs12466, rs1592085, rs4915499, rs12134467, rs10158798, rs1954214, rs12046907, rs10920161, rs12117501, rs1997018, rs1880450, rs1857489, rs16848184, rs8683
  • Polymorphic sites in the region containing THRB of human chromosome 3 include single nucleotide polymorphism international numbers rs1397878, rs6765461, rs6801153, rs1464010, rs7630879, rs6550848, rs826375, rs1667765, rs826378, rs6808673, rs2519423, rs17194828, rs1562736, rs9310730, rs2683535, rs7652337, rs7652444, rs2683542, rs1667739, rs1505302, rs6799431, rs17014338, rs826249, rs10510540, rs6772213, rs851719, rs6792783, rs1354605, rs866651, rs958892, rs826225, r
  • Examples of the polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 include single nucleotide polymorphism international numbers rs13088412, rs9837084, rs744876, rs571170, rs358954, rs9833515, rs6440716, rs358967, rs1993404, rs9883677, rs2048229, rs16863149, rs891666, rs1835668, rs6787683, rs16863204, rs16863208, rs16863229, rs3732755, rs3773614, rs1231521, rs3108727, rs3773619, rs7649855, rs16863264, rs2870518, rs3846072, rs67813395, rs
  • the polymorphic site in the region containing SORBS2 of human chromosome 4 includes single nucleotide polymorphism international numbers rs10866277, rs12645545, rs12649063, rs7437897, rs11132327, rs10866278, rs6823490, rs6843640, rs6818789, rs2512307, rs6552895, rs6552896, rs6552897, rs12498673, rs10025265, rs2306707, rs3749579, rs6848934, rs2306703, rs11934819, rs4862558, rs4599460, rs4862559, rs6823546, rs11132334, rs5018568, rs904451, rs7677363, rs2030144, rs11132338,
  • Polymorphic sites in the region containing GLRX and / or C5orf27 of human chromosome 5 include single nucleotide polymorphism international numbers rs34896, rs34897, rs3777220, rs3777217, rs11738579, rs3777213, rs7736948, rs6556883, rs9314160, rs6876015, rs11135436, rs17085165, rs17085170, rs10040697, rs6884979, rs7702848, rs2080947, rs10476660, rs154454, rs147295, rs17085249, rs11741590, rs3777194, rs2270554, rs3777190, rs3777188 and rs4642392, NCBI (v36.1) 95206085, etc. None happen.
  • Polymorphic sites in the region containing EBF1 of human chromosome 5 include single nucleotide polymorphism international numbers rs2913384, rs173423, rs244654, rs824854, rs824848, rs1095103, rs403334, rs10515769, rs2112262, rs33196, rs17056089, rs2042875, rs3843489, rs1541649, rs17056186, rs2116727, rs10067813, rs7709065, rs17056205, rs1368298, rs4704963, rs10070743, rs4704967, rs10056564, rs6875710, rs17643057, rs6883655, rs891903, rs10054046, rs6556373, rs4921538, 655 Examples include
  • Polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 include single nucleotide polymorphism international numbers rs1044043, rs10484565, rs241438, rs1800454, rs241429, rs241427, rs4711312, rs2071482 , Rs4148882, rs12529313, rs9276815, rs92547, rs9276825, rs9276832, rs241404, rs241403, rs3101942, rs241400, rs3132132, rs151719, rs1050391, rs9378127, rs188245, rs3129305, rs176248, rs12216336, rs2894311, rs12191230, 1922391, , Rs399604, rs365066,
  • Polymorphic sites in the region including LOC100132919 of human chromosome 6 include single nucleotide polymorphism international numbers rs1338657, rs9485685, rs9377361, rs9377365, rs9377366, rs9322660, rs9322661, rs2399802, rs17063309, rs680011, rs9499111, rs9404214, rs1569366, rs1569367, Examples thereof include, but are not limited to, rs17443301, rs17063399, rs6906578 and rs7740643, NCBI (v36.1) 102984444, and the like.
  • polymorphic sites in the region containing AAA1 and / or NPSR1 of human chromosome 7 include the single nucleotide polymorphism international numbers rs1156490, rs6462540, rs1419842, rs2392267, rs1419803, rs1419805, rs1419809, rs6977125, rs17169769, rs17169771, rs7778512, rs1419840, rs35114106, rs1019089, rs16878925, rs1362172, rs2392270, rs17831435, rs10951417, rs1468559, rs10486643, rs6951496, rs7458608, rs2893480, rs4723375, rs1419863, rs1419864, rs9639694, rs9639695, 1737, rs
  • the polymorphic sites in the region containing ELMO1 of human chromosome 7 include single nucleotide polymorphism international numbers rs10277512, rs4720221, rs7787226, rs10951500, rs10274668, rs10255208, rs2006882, rs2392472, rs756507, rs2241152, rs7785934, rs7782979, rs17170754, rs3807162, rs3734948, rs741302, rs2041801, rs2049661, rs669276, rs4723592, rs11769038, rs4723598, rs1882080, rs4723601, rs11982286, rs1986619, rs1882082, rs10268319, rs17170799, rs6957979, rs10225164, r
  • the polymorphic sites in the region containing ANGPT1 of human chromosome 8 include single nucleotide polymorphism international numbers rs12549261, rs10955436, rs6981257, rs11774921, rs11781710, rs1954724, rs6997025, rs1892764, rs16875775, rs11778352, rs2584372, rs2246255, rs2022958, rs2022949, rs16875901, rs1010824, rs2507799, rs10505100, rs11777978, rs16875983, rs9297393, rs7009229, rs13257393, rs4077322, rs11997995, rs10505105, rs4133396, rs4133395, rs4341141, rs10505107, rs11780324,
  • polymorphic sites in the region containing PGM5 of human chromosome 9 include single nucleotide polymorphism international numbers rs3869296, rs7020465, rs11142449, rs11142461, rs10868851, rs13439981, rs7039076, rs265083, rs2131355, rs265087, rs265073, rs7861495, rs10869020, rs17085775, Examples thereof include, but are not limited to, rs11795256, rs10869034, rs1411992, rs10869043, rs12343877, rs11142941, rs869950, rs7046236, rs9644996, and the like.
  • Polymorphic sites in the region containing TMC1 of human chromosome 9 include single nucleotide polymorphism international numbers rs3012514, rs7846808, rs7027640, rs10781101, rs4526421, rs7853275, rs10869178, rs7864535, rs12004208, rs6560277, rs4573342, rs4132905, rs4073227, rs10121866, rs7044241, rs7855743, rs4373587, rs11143314, rs7047875, rs6560284, rs6560285, rs7857300, rs6560287, rs7866185, rs6560293, rs7026124, rs12346185, rs7041300, rs4307407, rs17095, rs10113863,
  • Polymorphic sites in the region containing ROR2 of human chromosome 9 include single nucleotide polymorphism international numbers rs6479357, rs9409602, rs10991978, rs10991988, rs7867934, rs1388966, rs902923, rs902922, rs10512215, rs1532230, rs12337820, rs7029450, rs2131304, rs2920304, rs9299395, rs1388967, rs4073736, rs4073735, rs9409652, rs10992075, rs7031729, rs17585790, rs16907725, rs16907728, rs4372069, rs16907761, rs16907764, rs17586213, rs7039620, rs16907768, r
  • Polymorphic sites in the region containing PPP6C and / or C9orf126 of human chromosome 9 include single nucleotide polymorphism international numbers rs7022663, rs7024526, rs2289631, rs10986505, rs16927802, rs12001999, rs10819019, rs6478690, rs1017530, rs3824507, rs12352758, rs4838242, rs650599, rs7860360, rs2113352, rs7019234, rs7867749, rs2271746, rs16927930, rs10986618, rs10986626, rs12237026, rs463774, rs420423, rs10986641, rs10513445, rs393721, rs10819043, rs10986689, rs
  • polymorphic sites in the region containing 11p11.2 of human chromosome 11 include single nucleotide polymorphism international numbers rs7124648, rs7128650, rs4587689 , Rs11039097, rs12796744, rs17197619, rs17790390, rs11039105, rs10501319, rs11039112, rs747650, rs7937410, rs17197710, rs1685404, rs2013867, rs901746, rs7118396, rs10838681, rs10501321, rs1051006, rs3816724, rs7124955, rs47510, rs7124955, rs47510 Rs11605672, rs153
  • the polymorphic sites in the region containing OR5R1 of human chromosome 11 include single nucleotide polymorphism international numbers rs1586004, rs7940239, rs10896302, rs17615246, rs10750820, rs1945245, rs3938998, rs10791979, rs1573511, rs12277883, rs7116573, rs10896333, rs4420287, rs1894026, rs1945213, rs1945211, rs7113069, rs11228306, rs12785840, rs10501353, rs1945203, rs585475, rs615231, rs617315, rs675991, rs7939886, rs4939052, rs621957, rs611534, rs594854, rs618594,
  • polymorphic sites in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 include single nucleotide polymorphism international numbers rs565976, rs534179, rs2276443, rs532454, rs511190, rs566818, rs482458, rs1793412, rs1790149, rs1790155, rs1790154, rs668727, rs11600640, rs611449, rs11236449, rs661928, rs621305, rs11236452, rs7128888, rs7129014, rs688727, rs674503, rs606452, rs11236458, rs599816, rs660343, rs541993, rs601142, rs648930, rs61
  • polymorphic sites in the region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 include single nucleotide polymorphism international numbers rs17120344, rs6589597, rs10790175, rs12420127, rs10892082, rs7107152, rs1242229, rs1784042, rs2269399 , Rs526602, rs664971, rs11216315, rs1263499, rs17120523, rs236919, rs528508, rs593245 and rs477036, NCBI (v36.1) 116617736, and the like, but are not limited thereto.
  • Polymorphic sites in the region containing TAOK3 of human chromosome 12 include single nucleotide polymorphism international numbers rs7297299, rs5745807, rs5745811, rs9739560, rs4767654, rs10638, rs9788041, rs11068799, rs11068803, rs10850953, rs7135008, rs11613924, rs7307331, rs9667334, rs7957463, rs10850956, rs2936840, rs904661, rs1726407, rs1726392, rs17440336, rs1277442, rs11068860, rs11068865, rs17512142, rs17440364, rs364823, rs418941, rs7974718, rs11068891, rs16948230,
  • polymorphic sites in the region including CARS2 of human chromosome 13 include single nucleotide polymorphism international numbers rs9521809, rs4773201, rs1106649, rs9521814, rs385037, rs7997619, rs912941, s1886871, rs2182271, rs912942, rs331596, rs9559844, rs331602, rs1536621, rs9521853, rs9559849, rs7999854, rs3858821, rs4771696, rs4773228, rs4773229, rs2765341, rs3742193, rs3742194, rs7323602, rs3759463, rs179356, rs330565, rs7394, rs389656, rs450514, rs445490
  • Polymorphic sites in the region containing CYP19A1 of human chromosome 15 include single nucleotide polymorphism international numbers rs6493469, rs12595526, rs8031702, rs17599974, rs16953045, rs10744956, rs2306335, rs6493470, rs7181201, rs11856609, rs1124769, rs17647040, rs12899586, rs12904155, rs7170455, rs7177664, rs8040954, rs17647084, rs4775916, rs1111266, rs16964077, rs1025738, rs7179084, rs7176579, rs16964113, rs10519293, rs17522553, rs12324478, rs1075681, rs2899469, rs
  • Polymorphic sites in the region containing LOC643542 of human chromosome 18 include single nucleotide polymorphism international numbers rs8086948, rs12457951, rs11151371, rs17077389, rs1480679, rs5000099, rs1480682, rs433411, rs370944, rs395074, rs379982, rs281571, rs1444106, rs2448716, rs1562072, rs1867412, rs17077583, rs764133, rs17828615, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112, rs2448755, rs2448745, rs2440527, rs28379561, rs10503118, rs1562070,
  • polymorphic sites in the region containing PTPRT of human chromosome 20 include single nucleotide polymorphism international numbers rs1884029, rs6072606, rs2207220, rs4812571, rs4572656, rs2013923, rs4812574, rs6513762, rs6513763, rs6029950, rs2144009, rs2866941, rs6102658, rs2144011, rs3787282, rs746413, rs4812578, rs6102671, rs1126101, rs6065434, rs4810352, rs1076666, rs6029980, rs6016688, rs2076249, rs17221018, rs17221067, rs17312515, rs17221137, rs6130047, rs16986551, rs
  • Polymorphic sites in the region containing ITSN1 of human chromosome 21 include single nucleotide polymorphism international numbers rs12626309, rs2834231, rs4817579, rs2834238, rs2211689, rs2834246, rs2834251, rs2834252, rs1537097, rs1892589, rs2073368, rs2409499, rs9978415, rs2268247, rs9979937, rs2834264, rs2834268, rs8794268, rs879261, rs2245099, rs1108000, rs9979150, rs743316, rs2300384, rs3746861, rs2834292, rs2834295, rs2040113, rs2834296, rs2834297, rs2239565,
  • Polymorphic sites in the region containing LRP2 of human chromosome 2 include single nucleotide polymorphism international numbers rs13416802, rs2287616, rs2287613, rs3770597, rs10200158, rs6761690, rs13430236, rs3814381, rs4148765, rs10490134, rs11902639, rs10183805, rs13403114, rs3815574, rs2302698, rs6750251, rs4667590, rs4668121, rs1990702, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs11679947, rs10490132, rs2239602, rs2024481, rs741378, rs2284679
  • Polymorphic sites in the region containing APIP and / or PDHX of human chromosome 11 include single nucleotide polymorphism international numbers rs523246, rs10501136, rs836950, rs12808574, rs10836315, rs502857, rs731726, rs731727, rs967751, rs1553760, rs1396880, rs2941043, rs2941042, rs2941061, rs2956079, rs2941054, rs1509662, rs2941052, rs2915234, rs891550, rs919554, rs2915232, rs2956086, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs3751078, 291513,
  • Polymorphic sites in the region containing CUX2 of human chromosome 12 include single nucleotide polymorphism international numbers rs7979656, rs10849918, rs2106407, rs2106406, rs12425190, rs11065783, rs2339706, rs4509829, rs7961663, rs4766526, rs4766442, rs4766443, rs12815195, rs12229654, rs756825, rs16941284, rs6489979, rs4766553, rs9783423, rs7952972, rs16941319, rs3809290, rs7962233, rs4766451, rs886126, rs2078851, rs1265566, rs2301658, rs7300082, rs7300860, rs16941414,
  • Polymorphic sites in the region containing TOM1L1 of human chromosome 17 include single nucleotide polymorphism international numbers rs2332297, rs2934884, rs16955216, rs2934890, rs7225247, rs16955225, rs9303359, rs7207731, rs17683089, rs11658131, rs2958944, rs2934909, rs2934914, rs2934921, rs2958933, rs7221313, rs7210248, rs2958921, rs8079105, rs16955327, rs12949718, rs9899602, rs17745123, rs8070668, rs9910653, rs17817829, rs12936860, rs12951898, rs17817950, rs2787501, NC
  • SNP single nucleotide polymorphism
  • normal tension glaucoma examination is an examination for determining whether or not a subject has a high or low possibility of having normal tension glaucoma. Tests to make a definitive diagnosis are included.
  • polymorphic site in the test method of the present invention refers to a gene ORF, a region that controls gene expression (for example, a promoter region, an enhancer region, etc.), a gene intron, or a linkage disequilibrium with these genes. It can exist in the area before and after that.
  • polymorphisms include single nucleotide polymorphisms, polymorphisms in which one to several tens of bases (sometimes several thousand bases) are substituted, deleted, inserted, transferred, or inverted. There is no particular limitation. Further, the number of polymorphic sites is not limited to one and may be plural.
  • identification of the base at the polymorphic site can be performed by the following method.
  • a method of comparing the intensity of hybridization using a probe specific for the polymorphic part A method for identifying a base incorporated into a polymorphic site during a polymerase base extension reaction initiated from a template-specific primer in the polymorphic region.
  • ⁇ Base-pair or non-complementary complementary to polymorphic region following template-specific primer To make the enzyme recognize the presence or absence of basic base pairs. The above are typical SNP detection methods, but the normal-tension glaucoma examination of the present invention is not limited to these methods.
  • genomic DNA may be extracted from the subject's biological sample.
  • biological samples include, for example, the subject's blood, skin, oral mucosa, tissues or cells collected or excised by surgery, body fluids collected for the purpose of examination (saliva, lymph, airway mucosa, semen, sweat, urine, etc.) ) Etc.
  • As the biological sample leukocytes or mononuclear cells separated from peripheral blood are preferable.
  • Genomic DNA can be extracted from a biological sample using a commercially available DNA extraction kit. Then, if necessary, DNA containing the polymorphic site is isolated. The DNA can be isolated by PCR or the like using genomic DNA or RNA as a template, using a primer capable of hybridizing to DNA containing a polymorphic site.
  • the present invention also provides a reagent for examining normal-tension glaucoma, which comprises at least one component selected from the group consisting of the following components (a) and (b): .
  • Polymorphic site in human chromosome 6 containing ELOVL5, polymorphic site in human chromosome 2 containing SRBD1, polymorphic site in human chromosome 3 containing ARPP-21, human chromosome 4 EPHA5 The polymorphic site in the region containing GMDS, the polymorphic site in the region containing GMDS of human chromosome 6, the polymorphic site in the region containing 6p21.3 of human chromosome 6 (including HSPA1B), and SYTL3 of human chromosome 6
  • the present invention provides a test kit for normal-tension glaucoma containing the above reagent.
  • the above primers and probes may be oligonucleotides having a chain length of at least 15 nucleotides.
  • the oligonucleotide When the oligonucleotide is used as a primer, its length is usually 15 to 100 bp, preferably 17 to 30 bp.
  • the primer is not particularly limited as long as it can amplify at least a part of the DNA containing the polymorphic site.
  • the length of DNA that can be amplified by the primer is usually 15 to 1000 bp, preferably 20 to 500 bp, more preferably 20 to 200 bp.
  • the oligonucleotide When the oligonucleotide is used as a probe, the length is usually 15 bp to 500 bp, preferably 30 bp to 500 bp.
  • the probe is not particularly limited as long as it can hybridize with the DNA containing the polymorphic site.
  • the length of DNA to which the probe can hybridize is usually 16 to 500
  • a primer capable of amplifying a region containing a polymorphic site is preferably one that can initiate complementary strand synthesis toward the polymorphic site using a DNA containing the polymorphic site as a template.
  • an arbitrary base sequence can be added to the primer.
  • a primer for a polymorphism analysis method using a type IIs restriction enzyme a primer to which a recognition sequence for a type IIs restriction enzyme is added is used.
  • the primer may be modified.
  • a primer labeled with a fluorescent substance or a binding affinity substance such as biotin or digoxin may be used.
  • the probe that can hybridize to the region containing the polymorphic site may be any probe that can hybridize to the polynucleotide having the base sequence of the region containing the polymorphic site.
  • Those that specifically hybridize to DNA having the base sequence of the region to be included are preferred.
  • “specifically hybridizes” means normal hybridization conditions, preferably stringent hybridization conditions (for example, Sambrook et al., Molecular® Cloning, Cold® Spring® Harbor® Laboratory® Press, New® York, USA, In the condition described in the second edition 1989), it means that cross-hybridization does not occur significantly with DNA other than DNA having the base sequence of the region containing the polymorphic site.
  • a probe containing a polymorphic site in the base sequence of the probe is preferable.
  • the probe may be designed so that the end of the probe corresponds to a base adjacent to the polymorphic site. Therefore, although the polymorphic site is not included in the base sequence of the probe itself, a probe including a base sequence complementary to the region adjacent to the polymorphic site can also be shown as a desirable probe in the present invention.
  • the probe is allowed to modify the base sequence, add the base sequence, or modify the base sequence in the same manner as the primer.
  • a probe used for the Invader method is added with a base sequence unrelated to the genome constituting the flap.
  • Such a probe is also included in the probe of the present invention as long as it hybridizes to a region containing a polymorphic site.
  • the base sequence constituting the probe of the present invention can be designed according to the analysis method based on the base sequence of the DNA region surrounding the polymorphic site of the present invention in the genome.
  • primers and probes can be designed according to the analysis method based on the base sequence information about the surrounding DNA region including the polymorphic site.
  • the base sequences constituting the primers and probes can be modified as appropriate as well as the base sequences that are completely complementary to the genomic base sequences.
  • Primers and probes can be synthesized by any method based on the base sequences constituting them.
  • a technique for synthesizing an oligonucleotide having the base sequence based on the given base sequence is known.
  • any modification can be introduced into the oligonucleotide using a nucleotide derivative modified with a fluorescent dye or biotin.
  • a method of binding a fluorescent dye or the like to a synthesized oligonucleotide is also known.
  • the probe may be fixed on a solid phase (DNA array).
  • sample DNA or RNA
  • RNA is hybridized to a large number of probes arranged on the same plane, and the hybridization to each probe is detected by scanning the plane. Since responses to many probes can be observed simultaneously, for example, a DNA array is useful for analyzing a large number of polymorphic sites simultaneously.
  • nucleotide immobilization (array) methods include arrays based on oligonucleotides developed by Affymetrix. In an array of oligonucleotides, the oligonucleotides are usually synthesized in situ. For example, in-situ synthesis methods of oligonucleotides by lithography method (Affymetrix), inkjet method (Agilent), bead array method (Illumina), etc. are known.
  • Oligonucleotide is composed of a base sequence complementary to a region containing a polymorphic site to be detected.
  • the length of the nucleotide probe to be bound to the substrate is usually 10 to 100 bp, preferably 10 to 50 bp, more preferably 15 to 25 bp when the oligonucleotide is immobilized.
  • a sample for SNP detection by the DNA array method can be prepared by a method well known to those skilled in the art based on a biological sample collected from a subject.
  • the biological sample is not particularly limited.
  • a DNA sample can be prepared from genomic DNA extracted from tissues or cells of peripheral blood leukocytes, skin, oral mucosa, etc., tears, saliva, urine, feces or hair of the subject.
  • a specific region of genomic DNA is amplified using a primer for amplifying a region containing a polymorphic site to be determined.
  • a plurality of regions can be simultaneously amplified by the multiplex PCR method.
  • the multiplex PCR method is a PCR method using a plurality of primer sets in the same reaction solution. When analyzing multiple polymorphic sites, the multiplex PCR method is useful.
  • a DNA sample is amplified by the PCR method and the amplified product is labeled.
  • a labeled primer is used for labeling the amplification product.
  • genomic DNA is first amplified by PCR using a primer set specific to the region containing the polymorphic site.
  • biotin-labeled DNA is synthesized by a labeling PCR method using a biotin-labeled primer.
  • the biotin-labeled DNA synthesized in this way is hybridized to the oligonucleotide probe on the chip.
  • the hybridization reaction solution and reaction conditions can be appropriately adjusted according to conditions such as the length of the nucleotide probe immobilized on the solid phase and the reaction temperature.
  • One skilled in the art can design appropriate hybridization conditions.
  • avidin labeled with a fluorescent dye is added.
  • the array is analyzed with a scanner, and the presence or absence of hybridization is confirmed using fluorescence as an index.
  • An example of a procedure for carrying out the test method of the present invention using the DNA array method is as follows. After preparing a solid phase on which a DNA and nucleotide probe containing a polymorphic site prepared from a subject are immobilized, The solid phase is contacted. Subsequently, the base species of the polymorphic site is determined by detecting DNA hybridized to the nucleotide probe immobilized on the solid phase.
  • solid phase means a material capable of immobilizing nucleotides.
  • the solid phase is not particularly limited as long as nucleotides can be immobilized, and specific examples include a solid phase containing microplate wells, plastic beads, magnetic particles, a substrate, and the like.
  • a substrate generally used in DNA array technology can be preferably used.
  • the “substrate” means a plate-like material capable of fixing nucleotides.
  • the nucleotide includes oligonucleotides and polynucleotides.
  • an allele-specific oligonucleotide (Aligonucleotide / ASO) hybridization method can be used to detect a base at a specific site.
  • An allele-specific oligonucleotide (ASO) is composed of a base sequence that hybridizes to a region where a polymorphic site to be detected exists.
  • ASO is hybridized to sample DNA, the hybridization efficiency decreases if a mismatch occurs at the polymorphic site due to the polymorphism.
  • Mismatches can be detected by Southern blotting or a method that uses the property of quenching by intercalating a special fluorescent reagent into the hybrid gap. Mismatches can also be detected by the ribonuclease A mismatch cleavage method.
  • the reagents and kits of the present invention can contain various enzymes, enzyme substrates, buffers, and the like depending on the base identification method.
  • the enzyme include enzymes necessary for the various analysis methods exemplified as the base identification method, such as DNA polymerase, DNA ligase, or IIs restriction enzyme.
  • the buffer solution a buffer solution suitable for maintaining the activity of the enzyme used for these analyzes is appropriately selected.
  • the enzyme substrate for example, a substrate for complementary strand synthesis is used.
  • a control in which the base at the polymorphic site is clear can be attached to the reagent and kit of the present invention.
  • genomic DNA or a fragment of genomic DNA in which the base type of the polymorphic site is known in advance can be used.
  • Genomic DNA extracted from cells may be attached as a control, or a cell or a fraction of cells may be attached as a control, and a user may extract genomic DNA therefrom. If a cell is used as a control, the result of the control can prove that the genomic DNA extraction operation was performed correctly.
  • DNA comprising a base sequence containing a polymorphic site can be used as a control.
  • a YAC vector or a BAC vector containing a genome-derived DNA whose base type at the polymorphic site has been clarified may be used as a control.
  • a vector in which only tens to hundreds of bp corresponding to the polymorphic site are excised and inserted can be used as a control.
  • the present invention also includes a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, a region containing ARPP-21 of human chromosome 3, a region containing EPHA5 of human chromosome 4, The region containing 6 chromosomes of GMDS, the region containing human chromosome 6p21.3 (including HSPA1B), the region containing human chromosome 6 SYTL3, the region containing human chromosome 7 NXPH1, the region of human chromosome 7 A region containing LHFPL3, a region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, a region containing PAX7 of human chromosome 1, a region containing PTPRF of human chromosome 1, Region containing 1q12-q21.1 (including CHD1L and / or FMO5), region containing 1q21.2-q21.3 (including FDPS and /
  • Polymorphic site in human chromosome 6 containing ELOVL5, polymorphic site in human chromosome 2 containing SRBD1, polymorphic site in human chromosome 3 containing ARPP-21, human chromosome 4 EPHA5 The polymorphic site in the region containing GMDS, the polymorphic site in the region containing GMDS of human chromosome 6, the polymorphic site in the region containing 6p21.3 of human chromosome 6 (including HSPA1B), and SYTL3 of human chromosome 6
  • the marker gene of the present invention is usually 10 bases or longer, preferably 20 bases or longer. For example, it may be 50 base length, 100 base length, 200 base length, 300 base length, 600 base length, 1000 base length or the like including the polymorphic site.
  • the ORF of the gene the region controlling the expression of the gene (for example, promoter region, enhancer region, etc.) can be determined.
  • the amino acid sequence of the polypeptide encoded by ORF can be determined.
  • the polypeptide encoded by the DNA sequence of the marker gene of the present invention is obtained by culturing host cells transformed with a vector containing the DNA sequence (or at least a fragment thereof containing a translation region), and culturing the polypeptide from the culture. Can be produced.
  • the present invention also provides a vector containing the DNA sequence of the marker gene of the present invention and a host cell transformed with the vector.
  • the DNA sequence of the marker gene of the present invention can be produced, for example, as follows. MRNA is extracted from a human biological sample (for example, blood of a healthy person or a patient), and cDNA is synthesized using reverse transcriptase and oligo dT primer. Using this as a template, the marker gene of the present invention is amplified by PCR.
  • a vector (recombinant vector) containing the DNA sequence of the marker gene of the present invention can be obtained by a known method (for example, the method described in Molecular Cloning 2nd Edition, J. Sambrook et al., Cold Spring Harbor Lab. Press, 1989). It can be obtained by inserting the DNA sequence of the marker gene of the present invention into an appropriate expression vector.
  • plasmids derived from E. coli eg, pBR322, pBR325, pUC12, pUC13
  • plasmids derived from Bacillus subtilis eg, pUB110, pTP5, pC194
  • yeast-derived plasmids eg, pSH19, pSH15
  • ⁇ phage etc.
  • Bacteriophages, animal viruses such as retroviruses and vaccinia viruses, insect pathogenic viruses such as baculoviruses, and the like can be used.
  • a promoter, enhancer, splicing signal, poly A addition signal, selection marker, SV40 replication origin, etc. may be added to the expression vector.
  • the expression vector may be a fusion protein expression vector.
  • fusion protein expression vectors are commercially available: pGEX series (Amersham Pharmacia Biotech), pET CBD Fusion System 34b-38b (Novagen), pET Dsb Fusion Systems 39b and 40b (Novagen), pET GST Fusion System 41 and 42 (Novagen).
  • a transformant can be obtained by introducing a vector (recombinant vector) containing the DNA sequence of the marker gene of the present invention into a host cell.
  • Host cells include bacterial cells (eg, Escherichia, Bacillus, Bacillus, etc.), fungal cells (eg, yeast, Aspergillus, etc.), insect cells (eg, S2 cells, Sf cells, etc.), animal cells ( Examples thereof include CHO cells, COS cells, HeLa cells, C127 cells, 3T3 cells, BHK cells, HEK293 cells), plant cells, and the like.
  • bacterial cells eg, Escherichia, Bacillus, Bacillus, etc.
  • fungal cells eg, yeast, Aspergillus, etc.
  • insect cells eg, S2 cells, Sf cells, etc.
  • animal cells examples thereof include CHO cells, COS cells, HeLa cells, C127 cells, 3T3 cells, BHK cells, HEK293 cells
  • plant cells and the like.
  • the transformant can be cultured in a medium, and the polypeptide encoded by the DNA sequence of the marker gene can be collected from the culture.
  • the medium may be recovered, the polypeptide separated from the medium, and purified.
  • the polypeptide is produced in a transformed host cell, the cell may be lysed, the polypeptide separated from the lysate and purified.
  • the polypeptide When the polypeptide is expressed in the form of a fusion protein with another protein (functioning as a tag), the fusion protein is separated and purified, and then treated with FactorXa or an enzyme (enterokinase).
  • the target polypeptide can be obtained by cleaving the protein.
  • Separation and purification of the polypeptide can be performed by known methods.
  • Known separation and purification methods include methods that utilize differences in solubility such as salting out and solvent precipitation, dialysis, ultrafiltration, gel filtration, and SDS-polyacrylamide gel electrophoresis.
  • Method utilizing difference method utilizing charge difference such as ion exchange chromatography, method utilizing specific affinity such as affinity chromatography, method utilizing hydrophobic difference such as reverse phase high performance liquid chromatography
  • NTG is considered to be a multifactorial disease that increases the risk of onset due to a large number of many genetic factors.
  • MYOC, OPA1 and OPTN genes have been reported as susceptibility genes for glaucoma including NTG, but these are only found in a few percent of glaucoma patients and show little correlation in Japanese. . Therefore, in order to comprehensively identify the NTG disease susceptibility genes, the present inventor analyzed all 500,000 SNPs at a high throughput at a time using the GeneChip Mapping 500k Array set of Affymetrix. Exhaustive genetic screening for genomic regions was performed. In addition, because the analysis data of this study is enormous and cannot be handled by conventional databases, we developed a database for SNP analysis that supports correlation analysis using a large amount of SNP.
  • SNP typing output file of Gene Chip 250k and 500k can be input as database input file
  • SNP ID and rs used in GTYPE It is possible to manage the correspondence with number, position information, neighboring gene information, and allele type known allele information (Hapmap), and (iii) Haploview and other input text formats for various analysis software can be arbitrarily specified and obtained as an output file
  • a database that can search, sort, extract and display registered data and analysis results has been constructed.
  • the DNA concentration was quantified using a PicoGreen quantification kit (PicoGreen ds DNA Quantification Reagent and Kit 200-2000 assay) to prepare a uniform DNA concentration for each sample. Thereafter, the whole genome was cleaved with a restriction enzyme, and an adapter recognizing a specific protruding terminal of 4 bases was ligated. The DNA fragment to which the adapter was added was amplified by PCR, fragmented and labeled, and then hybridized to Mapping 250k Array.
  • PicoGreen quantification kit Pieric Acids DNA Quantification Reagent and Kit 200-2000 assay
  • the alleles of each SNP were analyzed from the fluorescence intensity of each probe with a laser scanner using the Direct Model (DM) Algorithm. Based on the obtained results, the allele distribution of the patient group and the healthy group is statistically analyzed for each SNP, and the genes that correlate with the disease are determined. Experimental accuracy and contamination were evaluated using modified partitioning aroundmethods (MPAM) algorithm. SNP typing using Affymetrix GeneChip (registered trademark) mapping 500k array was completed for 266 NTG patients. The SNP call rate (the proportion of SNPs that were analyzed properly) averaged over 95% for both NspI and StyI arrays, indicating good typing accuracy.
  • MPAM modified partitioning aroundmethods
  • Rs Id represents the rs number
  • Chromosome represents the chromosome
  • Position represents the NCBI (v36.1) number
  • Astat2 P Value (2x2) represents the p value.
  • the present invention can be used for life science, medicine, ophthalmology and diagnosis.
  • Takahashi H, Ohtake Y, Kubota R, et al. [Two families with primary open-angle glaucoma associated with myocilin gene mutations].

Abstract

Disclosed is a gene sensitive to a normal-tension glaucoma disease.  Also disclosed is a method for utilizing the gene. Comprehensive analysis/comparison was made on single nucleotide polymorphisms on the entire genome in many normal-tension glaucoma patients and many normal persons, and it is found that there is a difference in polymorphism sites found in ELOVL5-containing regions on human chromosome-6 and the like among the patients and the normal persons, wherein the polymorphism sites are represented by the international single nucleotide polymorphism numbers rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730, rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs1429146, rs9463895, rs2235723, rs1346603, rs9474476, rs2294867, rs9349660, rs974323, rs6909592, rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517, rs9370201, rs9367529, rs12209741, rs7744451, rs6904083, rs6904376, rs9367532, rs2067833, rs9382212, rs2139077, rs2397146, rs7742367, rs9474576, rs622447, rs3736729, rs13212365 and rs761141.  It becomes possible to diagnose normal-tension glaucoma based on the difference in those polymorphism sites.

Description

正常眼圧緑内障疾患感受性遺伝子及びその利用Normal-tension glaucoma disease susceptibility gene and use thereof
　本発明は、正常眼圧緑内障疾患感受性遺伝子及びその利用に関する。 The present invention relates to a normal pressure glaucoma disease susceptibility gene and use thereof.
　緑内障は正常視機能を維持できる健常眼圧以上の眼圧上昇のために、視神経に傷害を来す進行性の難治性疾患である。放置すると視野狭窄が進行し、失明することのある疾患で、現在本邦の失明原因の第一位を占めているのにも関わらず、その原因は不明であり正確な診断法、有効な治療法および予防法は存在しない。日本人ではそのなかでも眼圧が正常範囲にあるにも関わらず緑内障を発症する正常眼圧緑内障（NTG）が最も多く、その頻度は40歳以上の約4％である。NTGは眼圧が正常範囲にあるため、眼圧検査では発見することが困難であり、健康診断や通常の眼科検査では見落とされがちである。視神経の障害は回復しないため、NTGにおいては早期発見・早期治療が最も重要である大切である。しかしながら、その進行は遅く、かつ中心視野は後期に障害を受けるため自覚症状に乏しく、本人も気づかないうちに視神経傷害が進行する。 Glaucoma is a progressive refractory disease that causes damage to the optic nerve due to an increase in intraocular pressure that exceeds normal ocular pressure that can maintain normal visual function. If left untreated, the visual field stenosis may progress and cause blindness. Although it is currently the leading cause of blindness in Japan, the cause is unknown and accurate diagnosis and effective treatment are available. And there is no prevention. Among Japanese people, normal-tension glaucoma (NTG), which develops glaucoma even though the intraocular pressure is in the normal range, is the most common, and the frequency is about 4% over 40 years of age. NTG has a normal range of intraocular pressure, so it is difficult to detect by intraocular pressure test, and is often overlooked in health examinations and normal ophthalmic examinations. Since optic nerve damage does not recover, early detection and treatment are the most important in NTG. However, the progression is slow, and the central visual field is damaged late, so that subjective symptoms are poor, and the optic nerve injury progresses without the user's knowledge.
　正常眼圧緑内障疾患感受性遺伝子の探索はおこなわれているが、未だに疾患と連鎖する遺伝子は発見されていない。いくつかの候補遺伝子解析が進められてきた。緑内障との関連が強く疑われているmyocilin（非特許文献1-15）そしてoptineurin（非特許文献16-30）、optic atrophy 1（非特許文献31-41） 遺伝子の解析がそれぞれ精力的におこなわれてきたがNTGとの関連は明らかではない。また、候補と考えられる遺伝子の解析も進められているが、関連の示唆までにしかいたっていない。 Although a search for a gene for susceptibility to normal-tension glaucoma disease has been conducted, a gene linked to the disease has not yet been found. Several candidate gene analyzes have been undertaken. Myocilin (Non-patent Documents 1-15), optineurin (Non-patent Documents 16-30), and optic atrophy 1 (Non-patent Documents 31-41), which are strongly suspected to be associated with glaucoma, are energetically analyzed. However, the relationship with NTG is not clear. In addition, the analysis of genes considered as candidates is also underway, but it has only reached a suggestion of association.
　本発明は、正常眼圧緑内障疾患感受性遺伝子を見出し、その利用方法を提供することを目的とする。 An object of the present invention is to find a normal-tension glaucoma disease susceptibility gene and provide a method for using the gene.
　本発明者は、正常眼圧緑内障患者と正常人を対象に全ゲノム上のSNPを網羅的に解析・比較した結果、複数の遺伝子に相違があることを見出した。本発明はその知見に基づいて完成された。 As a result of comprehensive analysis and comparison of SNPs in the entire genome for normal pressure glaucoma patients and normal persons, the present inventor has found that there are differences in a plurality of genes. The present invention has been completed based on the findings.
　本発明の要旨は以下の通りである。 The gist of the present invention is as follows.
（１）ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位の塩基を同定することを含む、正常眼圧緑内障の検査方法。 (1) Region of human chromosome 6 containing ELOVL5, region of human chromosome 2 containing SRBD1, region of human chromosome 3 containing ARPP-21, region of human chromosome 4 containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 And / or FLJ14126 region, human chromosome 3 THRB region, human chromosome 3 MED12L and / or CLRN10S and / or GPR171 region, human chromosome 4 SORBS2 region, human chromosome 5 A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6 .3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human 8 Region containing TNKS of chromosome, region containing ANGPT1 of human chromosome 8, region containing PGM5 of human chromosome 9, region containing TMC1 of human chromosome 9, region containing ROR2 of human chromosome 9, human 9 Region containing PPP6C and / or C9orf126 of chromosome, G of human chromosome 10 A region containing RID1, a region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, Region containing MS4A7 and / or MS4A14 of chromosome 11, region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 , A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, and a region containing CA10 of human chromosome 17 A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, an APIP of human chromosome 11 and / or Region containing PDHX Identifying a base of at least one polymorphic site in at least one region selected from the group consisting of a region comprising CUX2 of chromosome 12 and a region comprising TOM1L1 of human chromosome 17. Inspection method for pressure glaucoma.
（２）ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs222450、rs9474394、rs2816344、rs2816341、rs2518579、rs2518578、rs9367511、rs6915699、rs6930045、rs9370188、rs9382180、rs9382181、rs4486010、rs2816379、rs6939730、rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs10948744、rs12183976、rs2562898、rs735860、rs715441、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201、rs9367529、rs12209741、rs7744451、rs6904083、rs6904376、rs9367532、rs2067833、rs9382212、rs2139077、rs2397146、rs7742367、rs9474576、rs622447、rs3736729、rs13212365及びrs761141からなる群より選択され、
　ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs11686431、rs7580559、rs3908093、rs2343412、rs12623996、rs7573149、rs918810、rs6721199、rs7579209、rs10194925、rs17033378、rs2343466、rs17033398、rs6737172、rs4953226、rs3851333、rs12473388、rs11681887、rs35608719、rs11888802、rs11678872、rs2343468、rs13003019、rs6760244、rs12471726、rs2081297、rs10460504、rs7562458、rs4953230、rs4952763、rs6719211、rs1014454、rs3755070、rs3213787、rs10210691、rs3770251、rs4455206、rs3755076、rs3770254、rs11125017、rs3770264、rs10205197、rs10427308、rs17033745、rs3770278、rs17322370、rs6736954、rs10427402、rs4476395、rs13023749、rs17033801、rs755652、rs748573、rs6708810、rs6710581、rs12712945、rs17033871、rs3755082、rs6544840、rs7599740、rs11884064、rs7596942、rs7565326、rs17323037、rs1916231、rs1517001、rs1522988、rs614281、rs582213、rs650508、rs666334、rs17033965、rs556650、rs2204204、rs3795863、rs2285024、rs505310、rs10490342、rs612717、rs10490341、rs656823、rs563601、rs609573、rs6746467、rs637889、rs10495926、rs1522986、rs1522987、rs6544843及びrs6724488からなる群より選択され、
　ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs1523048、rs1523029、rs12487524、rs1403468、rs872133、rs1523040、rs1523041、rs13069451、rs12629480、rs1357449、rs6801949、rs17033355、rs9873254、rs9839823、rs6794354、rs6794373、rs12637211、rs9855328、rs2037538、rs2037539、rs1523038、rs11718271、rs1608314、rs2197728、rs9311101、rs10490870、rs17033506、rs12634096、rs2359774、rs9860326、rs4678788、rs3213953、rs6799641、rs17201627、rs4678789、rs12632607、rs11129660、rs11129662、rs17033672、rs17280201、rs6779091、rs3772395、rs9872664、rs1963934、rs35102908、rs4678802、rs4678803、rs6550367、rs17033738、rs6801590、rs17033748、rs9865772、rs17033755、rs17228111、rs2016955、rs2016975、rs735353、rs11920715、rs1378481、rs17814981、rs1455489、rs4678509、rs10510667、rs6799649、rs6799609、rs17033836、rs4234248、rs6770245、rs10865865、rs7615307、rs9845811、rs17033961、rs1488092、rs10461001及びrs17033999からなる群より選択され、
　ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs170654、rs1514271、rs2063419、rs13102419、rs11131589、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs4860651、rs11938753、rs1376417、rs10025570、rs1376416、rs2084682、rs7658065、rs9312144、rs1376412、rs17086181、rs17086185、rs6847413、rs2198103、rs12509018、rs17082122、rs6823779、rs17086224、rs1451170、rs4289492、rs4371663、rs9986026、rs9991256、rs4267782、rs7660334、rs6815080、rs11737314、rs4365778、rs7673091、rs4320185、rs4604104、rs7684022、rs4860679、rs6844942、rs12644315、rs4599467、rs6834811、rs4320186、rs4487412、rs7667410、rs4611975、rs4370201、rs4438803及びrs4608860からなる群より選択され、
　ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs11966212、rs2143396、rs6911992、rs9378593、rs9392253、rs9378594、rs2050158、rs9391900、rs6596786、rs2235706、rs9378596、rs1997773、rs6926322、rs7754106、rs7750178、rs742520、rs2210370、rs6940618、rs349100、rs9405444、rs6932005、rs4959523、rs10484953、rs464778、rs115705、rs1013185、rs11242672、rs463641、rs4959525、rs369656、rs459162、rs127091、rs4959530、rs463264、rs7757477、rs448915、rs444018、rs443971、rs9391913、rs238048、rs238050、rs9378605、rs2459602、rs2438074、rs12191625、rs2438077、rs2496292、rs2496301、rs2438083、rs977674、rs977673、rs17259747、rs1437288、rs7772349、rs6596805、rs1347656、rs6925983、rs1550199、rs11242676、rs7744559、rs11966550、rs9378290、rs9405136、rs9405470、rs9392285、rs9405137、rs9405471、rs746095、rs9378623、rs9378292、rs1711957、rs7742720、rs9378629、rs7741690、rs9328052、rs9328053、rs1922938、rs2745636、rs2816242、rs932410、rs1474721、rs9392296、rs9502950、rs6907725、rs9405484、rs4443540、rs4355648、rs9328058、rs9328059、rs2569866、rs6935712、rs6935896、rs6937266、rs6925228、rs11242704、rs2816286、rs2816287、rs6596833、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs2317966、rs9392305、rs9501738、rs2569839、rs9328061、rs9378300、rs2816221、rs6916316、rs2281272、rs2569824、rs9405496、rs1810496、rs2814827、rs7759035、rs9502997、rs2814811、rs2317964、rs9378304、rs2569854、rs12206340、rs4538755、rs9378305、rs9503011、rs9405505、rs9503015、rs9501762、rs9405506、rs12197419、rs7765344、rs7765461、rs1013303、rs3800046、rs689035、rs2318108、rs6919059、rs6928276、rs226456、rs9378314、rs1157673、rs1157675、rs9391933、rs9328071、rs3778533、rs1028714、rs3800094、rs3778539、rs6596857、rs7776397、rs6596858、rs9378661、rs3823279、rs3800122、rs10484693、rs17772389、rs4959160、rs3778555、rs4463305、rs3800140、rs17134506、rs3800142、rs3800143、rs3800144、rs3800146、rs2761234、rs9405156、rs17134549、rs1408002、rs1830733、rs1830734、rs10223785、rs9405157、rs7772545、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs12212324、rs9392353、rs11242730、rs4580917、rs6910252、rs11242733、rs9503080、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs17134693、rs3800156、rs11242740、rs4959635、rs3800159、rs3778557、rs3800168、rs4959642、rs234930、rs9392372、rs234915、rs234914、rs3800184、rs234932、rs6903476、rs3778568、rs9405550、rs17134819、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs4413658、rs7449538、rs9503158、rs6902556、rs6925653、rs4281006、rs12210286、rs12213061、rs4959663、rs9501836、rs6911665、rs13200914、rs17135028、rs4959184、rs11242770、rs9328099、rs12206851、rs6904395、rs17609498、rs742487、rs4959185、rs9391949、rs9391950、rs6899721、rs1610416、rs3924452、rs10458144、rs9501850、rs9503199、rs4959677、rs35374935、rs2449448、rs1772982、rs1680885、rs2794569、rs2624936、rs12196957、rs2624933、rs1773000、rs1773001、rs1614248、rs1616044、rs2624917、rs2624916及びrs6899711からなる群より選択され、
　ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2248373、rs2248459、rs2248462、rs2248617、rs3749946、rs2523650、rs2904776、rs2516422、rs2905747、rs9267247、rs2395034、rs3095229、rs3131631、rs2516486、rs2734573、rs3115537、rs2516478、rs2071593、rs3219183、rs13215091、rs1799964、rs1052248、rs9348876、rs2857697、rs2736172、rs1046089、rs2255741、rs760293、rs2077102、rs3130048、rs2844463、rs805301、rs805300、rs805297、rs707921、rs2242655、rs707974、rs805268、rs805267、rs9378164、rs707918、rs805292、rs2299851、rs707939、rs707937、rs480092、rs2075800、rs2763979、rs11965547、rs486416、rs644045、rs537160、rs2072633、rs522162、rs550513、rs9296003、rs406936及びrs492899からなる群より選択され、
　ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs602698、rs678116、rs649930、rs643677、rs592698、rs675053、rs612557、rs629364、rs627967、rs628203、rs2771425、rs9355655、rs10499309、rs1041566、rs12530454、rs7753885、rs9347236、rs6455585、rs6931414、rs10447366、rs9457403、rs9355246、rs4709219、rs4708797、rs4709226、rs4709235、rs6925091、rs3799195、rs6913912、rs894124、rs6903405、rs6901469、rs9364496、rs7759006、rs6455600、rs2129209、rs6455601、rs9456350、rs3123094、rs9456352、rs3102970、rs6455604、rs3127188、rs3127194、rs3127196、rs3102966、rs3127168、rs923198、rs6924755、rs2361472、rs4569991、rs9457516、rs9456363、rs9365009、rs3923902及びrs12207795からなる群より選択され、
　ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs3807826、rs7802863、rs3757521、rs3757520、rs3807823、rs1861032、rs17145870、rs7805508、rs6977682、rs3807815、rs1008038、rs3807811、rs11769978、rs3779356、rs3807807、rs3807806、rs7455929、rs6463790、rs4620183、rs12668479、rs17147407、rs11762595、rs12702719、rs17147608、rs12154895、rs17403198、rs16873367、rs42949、rs2349188、rs6463805、rs7811039、rs10247446、rs10270530、rs7795595、rs6945018、rs17148966、rs1476623、rs10246412、rs17404198、rs6463813、rs17149337、rs17404218、rs11976158、rs10244689、rs6978212、rs757704、rs2214694、rs2189904、rs765855、rs17150199、rs10261060、rs4401754、rs10266489、rs5018942、rs4556000、rs10278603、rs7787432、rs6959052、rs17150410、rs17150472、rs17150479、rs17150761、rs10237485、rs4720785、rs972247、rs1859274、rs10238726、rs6970999、rs17151821、rs7456267、rs6963180、rs10257265、rs970526、rs977458、rs13240427及びrs17154007、並びにNCBI(v36.1)8484291からなる群より選択され、
　ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs41521、rs2188486、rs977641、rs17389507、rs10274138、rs17136882、rs13234807、rs7794181、rs7787988、rs7787976、rs17331134、rs1557689、rs6465984、rs7798273、rs2188494、rs1468143、rs10953427、rs2214087、rs4730006、rs6952170、rs17137313、rs4727599、rs17137382、rs10228106、rs42181、rs4730010、rs11763758、rs17137711、rs11763095、rs6977743、rs4520098、rs10216261、rs11972050、rs12539136、rs756669、rs41037、rs41038、rs28253、rs41058、rs9649272、rs6949801、rs9987005、rs6465994、rs6465995、rs1477110、rs12216618、rs10254402、rs6969323、rs9641335、rs10272959、rs3919550、rs4730030、rs10246540、rs4730031、rs2891730、rs995661、rs10487221、rs10487222、rs11773248、rs11983223、rs6943307、rs7782065、rs7801387、rs12705261、rs12531723、rs17269890、rs4730038、rs4584085、rs10216010、rs17141284、rs17141299、rs10953450、rs6466018、rs4530975、rs12705276、rs4283980及びrs2470965、並びにNCBI(v36.1) 103849313、104068646及び104196627からなる群より選択され、
　ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs470713、rs470935、rs641024、rs11606866、rs7131644、rs10894784、rs1031381、rs522134、rs4362160、rs473041、rs498602、rs554874、rs1144225、rs1595895、rs1146192、rs4936229、rs1144219、rs2510356、rs553231、rs512359、rs568044、rs10894798、rs10894799、rs11223765、rs10894800、rs7940114、rs10894801、rs10791357、rs3741100、rs3741098、rs7113199、rs1866769、rs1866768及びrs1561613からなる群より選択され、
　ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs3794941、rs17055278、rs514931、rs494721、rs17055426、rs2896769、rs12717033、rs7227977、rs10871527、rs10514139、rs17832851、rs17055756、rs1473224、rs2628125、rs8085262、rs8089151、rs2628123、rs4891199、rs17055919、rs10514148、rs17055185、rs2404482、rs10514149、rs4337381、rs2959165、rs12456768、rs4891217、rs9945585、rs9961644、rs9961742、rs9952375、rs13381156、rs9319675、rs2120144、rs8096648、rs17056218、rs2289609、rs4891228、rs1396098、rs894575、rs10871567、rs7242893及びrs7239800からなる群より選択され、
　ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs3000058、rs2816030、rs16862061、rs2816040、rs2816046、rs4920334、rs4920516、rs4920335、rs2816064、rs6704504、rs1934057、rs2298893、rs2743208、rs2076021、rs2076020、rs2236826、rs2282704、rs2282699、rs624761、rs851123、rs2236817、rs685300、rs2056446、rs2841078、rs4920344、rs6669544、rs4076925、rs6603910、rs11261070、rs7539659、rs11261074、rs7411058、rs4920545、rs6684577及びrs12565195からなる群より選択され、
　ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs2494997、rs1999674、rs2842180、rs2255632、rs2251804、rs1334973、rs6687571、rs2039528、rs2819341、rs10890251、rs2367617、rs11210864、rs2782641、rs11210871、rs10890257、rs12058744、rs11210879、rs11210886、rs516790、rs641365、rs673485、rs643445、rs10789438、rs11210892、rs617521、rs660899、rs2274465、rs10789439、rs489319、rs607062、rs10789442及びrs3791035、並びにNCBI(v36.1)43760103からなる群より選択され、
　ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200rs12122453、rs12122534、rs4950474、rs4950475、rs6593810、rs6657631、rs21327、rs517201、rs575115、rs2031481、rs2477568、rs2477569、rs692963、rs535827、rs4950361、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs2077749、rs17159914、rs6593745、rs2120003、rs10900325、rs2354432、rs6670503、rs1470261、rs6703187、rs10793652、rs7537483、rs7537703、rs1890038、rs3820130、rs3737845、rs17160062、rs3766525、rs4950315、rs17356240、rs10494244、rs6683839、rs10793656、rs17360443、rs3753433、rs12033407、rs7554833、rs10793661、rs10736837、rs10900336、rs7520661、rs4950409、rs2353983、rs6658836、rs17360812、rs6656156、rs12759145、rs12049491、rs10793682、rs4950431、rs7539416、rs2353969、rs4504949、rs17160205、rs2353967、rs12728058、rs6688308、rs11589438、rs6688154、rs6678706、rs4950436、rs7519891、rs11240053、rs11240054、rs11240055、rs7556087、rs7518276、rs2644579、rs2353951、rs2644577、rs6674761、rs2644566、rs2803535、rs17160256、rs12406844、rs17160264、rs612963、rs586000、rs17160295、rs644550及びrs17160305からなる群より選択され、
　ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs10752613、rs11583896、rs16835600、rs4434872、rs4567311、rs4363451、rs9427232、rs4845576、rs4520447、rs4845578、rs11585416、rs4845584、rs12033835、rs11581644、rs10908557、rs6701341、rs2297898、rs12048137、rs11264875、rs2066134、rs2494663、rs6671166、rs4845600、rs16835819、rs4521985、rs4620534、rs9803857、rs11265310、rs2340473、rs1194596、rs1212352、rs6672010、rs6702754、rs2274988、rs2297607、rs4414034、rs6696089、rs11265607、rs6427631、rs6427658、rs6694817、rs4537545、rs4845626、rs11265618、rs10752641、rs4240872、rs4474240、rs6700296、rs11265627、rs6691727、rs6687112、rs6427716、rs12136771、rs7553602、rs6660775、rs1127314、rs1127313、rs2131902、rs2229857、rs3766923、rs3766922、rs12125166、rs2335230、rs7531982、rs7533471、rs11264233、rs10796927、rs2335252、rs2036627、rs6699979、rs1995662、rs6664817、rs11264249、rs6426905、rs960182、rs16836320、rs868108、rs4845390、rs10494300、rs1051614、rs6666341、rs11808053、rs883319、rs1777910、rs951240ｖ、rs951241、rs9970364、rs1984285、rs6681725、rs16836414、rs10796934、rs10908445、rs4845678、rs4845679、rs4845681、rs12130132、rs10908448、rs4845690、rs4845406、rs10908455、rs7368345、rs10908456、rs4971079、rs4276913、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822519、rs822508、rs1749405、rs1749409、rs572609、rs3768280、rs2275078、rs2016251、rs1475766、rs12035615、rs4661146、rs6700693、rs10908489、rs11264449、rs2253677、rs2241110、rs2853641、rs2075163、rs2241107、rs1052053、rs1052067、rs759330、rs7542798、rs2253358、rs2842880、rs16837272、rs2287023、rs2246476、rs2248273、rs11264467、rs7522860、rs10908500、rs10494304、rs3795730、rs3762281、rs35478936、rs2274226、rs2985714、rs2842854、rs954916、rs6686886、rs11590409、rs4661040、rs7551781、rs16837376、rs11806983、rs1109751、rs11264486、rs3790458、rs1342442、rs12136856、rs10159180、rs1171564、rs1609666、rs728918、rs11264495、rs744224、rs4661184、rs879461、rs12742817、rs3795736、rs2236601、rs1046650及びrs3795737からなる群より選択され、
　ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs7521610、rs16850728、rs227521、rs227519、rs10047146、rs10489307、rs972484、rs1402640、rs10913291、rs12094495、rs10798503、rs6425414、rs7515582、rs10913294、rs7534953、rs10913295、rs725416、rs12090000、rs12564343、rs12031932、rs12079554、rs554454、rs6660903、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs16851037、rs17315298、rs2861972、rs1883243、rs6660559、rs4652245、rs4140633、rs7528533、rs3946142、rs6658794、rs9425456、rs6672376、及びrs12025407からなる群より選択され、
　ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1122396、rs1722755、rs6413916、rs831771、rs1404401、rs831767、rs16847944、rs831765、rs16847947、rs831764、rs16847951、rs831762、rs831753、rs16847994、rs831751、rs4915220、rs10157719、rs947379、rs12466、rs1592085、rs4915499、rs12134467、rs10158798、rs1954214、rs12046907、rs10920161、rs12117501、rs1997018、rs1880450、rs1857489、rs16848184、rs868381、rs854488、rs832169、rs832174、rs700469、rs860554rs1779301、rs2300293、rs2268156、rs832147、rs854502、rs1722780、rs1779293、rs854505、rs1572968、rs17425876、rs12143423、rs947377、rs10753899、rs17459837、rs6427900、rs1122481、rs2275862、rs11806184、rs2365652、rs2275860、rs947485、rs6671391、rs1256941、rs10800779、rs7553988、rs10920205、rs3887566、rs3888929、rs6427908及びrs12090950からなる群より選択され、
　ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs2577720、rs2723120、rs10495742、rs2577717、rs6720565、rs12053097、rs12613333、rs7566157、rs17045229、rs875077、rs17045238、rs2723129、rs2577698、rs2954818、rs12989910、rs11125011、rs6742888、rs7564616、rs2723111、rs6544822、rs893430、rs737564、rs737565、rs747344、rs6727901、rs7570872、rs17045350、rs6544861、rs6756357、rs4665214、rs10172684、rs1653748、rs1465677、rs1864807、rs1864808、rs4665218、rs10169643、rs1368080、rs10490750、rs11677730、rs7601971、rs1653751、rs1653753、rs1368081、rs11678782、rs11678785、rs4497835、rs1653780、rs17445645、rs4665223、rs4284788、rs4665612、rs1709339、rs6544949rs17045574、rs6544966、rs4665230、rs583168、rs17045705、rs2280122、rs1548020、rs518113、rs497973、rs3806510、rs13386930、rs6721623、rs3795933、rs7560892、rs4233701、rs9261、rs7579413、rs12470949、rs12478701、rs2081302、rs12478744、rs2339853及びrs35379186からなる群より選択され、
　ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6765461、rs6801153、rs1464010、rs7630879、rs6550848、rs826375、rs1667765、rs826378、rs6808673、rs2596623、rs17194828、rs1562736、rs9310730、rs2683535、rs7652337、rs7652444、rs2683542、rs1667739、rs1505302、rs6799431、rs17014338、rs826249、rs10510540、rs6772213、rs851719、rs6792783、rs1354605、rs866651、rs958892、rs826225、rs6550853、rs826223、rs826218、rs1466122、rs1449874、rs11719336、rs7625917、rs17787283、rs4858594、rs1449872、rs9849581、rs9863517、rs9843698、rs9867989、rs1667746、rs17787319、rs1505307、rs7640580、rs12639035、rs9810037、rs9833191、rs12630454、rs3951794、rs6781111、rs1505287、rs12495379、rs4858608、rs7624363、rs4640503、rs6550865、rs9839986、rs5014281、rs9831450、rs4241527、rs4858617、rs4858618、rs2196427、rs10490840、rs6788339、rs6765048及びrs892941からなる群より選択され、
　ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs13088412、rs9837084、rs744876、rs571170、rs358954、rs9833515、rs6440716、rs358967、rs1993404、rs9883677、rs2048229、rs16863149、rs891666、rs1835668、rs6787683、rs16863204、rs16863208、rs16863229、rs3732755、rs3773614、rs1231521、rs3108727、rs3773619、rs7649855、rs16863264、rs2870518、rs3846072、rs6782715、rs1882014、rs16863287、rs10513391、rs3773621、rs10935835、rs9863821、rs9864095、rs1873619、rs7623356、rs1491981、rs6440735、rs3971192、rs7644001、rs16863323、rs6801273、rs9820422、rs16863336、rs1388622、rs3975404、rs10513394、rs6787801、rs9289836、rs3821663、rs7429509、rs3821664、rs1491974、rs9653953、rs17204501、rs17204508、rs4680406、rs12490051、rs16863364、rs11708767、rs11709550、rs3732769、rs10935844、rs2276765、rs2276766、rs16863376、rs6440741、rs6771904、rs6772196、rs3732771、rs9864533、rs4435614、rs17204557、rs6798252、rs4680440、rs4680443、rs13088575、rs6790903、rs9289840、rs4680474、rs4541381、rs4596123及びrs7612205、並びにNCBI(v36.1)152200518、152229595、152456055及び152609183からなる群より選択され、
　ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10866277、rs12645545、rs12649063、rs7437897、rs11132327、rs10866278、rs6823490、rs6843640、rs6818789、rs2101307、rs6552895、rs6552896、rs6552897、rs12498673、rs10025265、rs2306707、rs3749579、rs6848934、rs2306703、rs11934819、rs4862558、rs4599460、rs4862559、rs6823546、rs11132334、rs5018568、rs904451、rs7677363、rs2030144、rs11132338、rs11132340、rs7669883、rs6858544、rs1027521、rs2173480、rs2173479、rs11132344、rs10084919、rs7677532、rs6835720、rs10024805、rs6834923、rs6812818、rs10015164、rs11132345、rs10024359、rs10000785、rs1039235、rs2310357、rs10028428、rs4862571、rs7684943、rs10021308、rs1566347、rs12504307、rs11132355、rs10028944、rs1499010、rs11724690、rs11940307、rs1566354、rs2648126、rs2648120、rs2648117、rs2648112、rs4861686、rs1026362、rs12643549、rs2310372、rs4862588、rs10031442、rs4637445、rs1947455、rs2278938、rs12641600、rs4862600、rs10002339、rs7694098、rs830829、rs830838、rs830841、rs2603731rs7697039、rs7697051、rs1356672、rs7679967、rs4861696、rs1519320及びrs12643213からなる群より選択され、
　ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs7733618、rs12514219、rs4532318、rs6861487、rs7700850、rs4587034、rs7705086、rs16895307、rs16895308、rs6890124、rs4339298、rs4613646、rs6862416、rs4532319、rs10515011、rs16895357、rs7732647、rs4355471、rs4554157、rs12055346、rs16895417、rs17210621、rs7706654、rs6864239、rs6896102、rs4374700、rs16895456、rs6880657、rs6863239、rs16895458、rs11953193、rs10940078、rs4446417、rs9791090、rs33721、rs33728、rs2548712、rs33696、rs257711、rs33724、rs26384、rs7704890、rs7725568、rs30729、rs26383、rs27637、rs26382、rs9918275、rs258082、rs257699、rs257700、rs16895719、rs30731、rs16895744、rs1835136、rs36157、rs36155、rs544158、rs36144、rs36143、rs26923、rs16895768、rs463219、rs16895790、rs26921、rs192295、rs26929、rs26928、rs461702、rs460844、rs455938、rs464881、rs456775、rs154620、rs17217092、rs154618、rs10056426、rs152407、rs37568、rs734828、rs2280174、rs16896071、rs40206、rs706701、rs17218390、rs6863305、rs39664、rs34691、rs34693、rs10044452、rs34698、rs34699、rs4016246、rs1159201、rs2662227、rs27206、rs469300、rs467845、rs2545396、rs16896246、rs16896295、rs17221226、rs2287929及びrs16896325、並びにNCBI(v36.1)65944399からなる群より選択され、
　ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs34896、rs34897、rs3777220、rs3777217、rs11738579、rs3777213、rs7736948、rs6556883、rs9314160、rs6876015、rs11135436、rs17085165、rs17085170、rs10040697、rs6884979、rs7702848、rs2080947、rs10476660、rs154454、rs147295、rs17085249、rs11741590、rs3777194、rs2270554、rs3777190、rs3777188及びrs4642392、並びにNCBI(v36.1)95206085からなる群より選択され、
　ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs2913384、rs173423、rs244654、rs824854、rs824848、rs1095103、rs403334、rs10515769、rs2112262、rs33196、rs17056089、rs2042875、rs3843489、rs1541649、rs17056186、rs2116727、rs10067813、rs7709065、rs17056205、rs1368298、rs4704963、rs10070743、rs4704967、rs10056564、rs6875710、rs17643057、rs6883655、rs891903、rs10054046、rs6556373、rs4921537、rs6556377、rs13180086、rs6556379、rs6556381、rs1544754、rs883540、rs17056426、rs17056435、rs1363561、rs9313797、rs1422672、rs17056474、rs17717829、rs10515787、rs10515786、rs10515789、rs9637861、rs7442845、rs12659540、rs3862065及びrs270661からなる群より選択され、
　ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs4493692、rs3797712、rs3797713、rs264881、rs36101422、rs264834、rs6879467、rs6883997、rs7721990、rs7713640、rs900464、rs264846、rs2161404、rs2306560、rs3816764、rs11134586、rs12515906、rs264844、rs2279318、rs264843、rs10063658、rs4867879、rs17736846、rs264838、rs12658902、rs2306558、rs262865、rs262840、rs262841、rs262842、rs155239、rs262848、rs262851、rs4867572、rs262852、rs746468、rs90213、rs17051884、rs262860、rs262859、rs10076580、rs6875474、rs185532、rs17669613、rs1013193、rs17669636、rs966595、rs17669654、rs13171272、rs261612、rs13163565、rs17737323、rs155074、rs261016、rs261597、rs166368、rs261633、rs10054135、rs261624、rs261625、rs17560224、rs4867895、rs168678、rs30080、rs30083、rs17670092、rs7717087、rs17737597、rs7729471、rs261039、rs261038、rs1482333、rs2291229、rs261021、rs261076、rs12515095、rs17646198、rs17560405、rs261067、rs261060、rs261006、rs261008、rs11740615、rs11741667、rs155023、rs11742527、rs978914、rs12522080、rs2624252、rs6896240、rs6862278、rs3860755、rs259897、rs259899、rs259900、rs259902、rs259903、rs6895199、rs259916、rs12659898、rs1422695、rs17738158、rs17561105、rs11134600、rs6893165、rs2161366、rs9313476、rs17738326、rs2287727、rs17738444、rs6884677、rs13152920、rs9790867、rs11134603、rs17738530、rs2134151、rs12055169、rs17738584、rs1316638、rs17072023、rs13361200、rs17738710、rs10462994、rs10462995、rs6890267、rs6871764、rs17671355、rs6555884、rs17562083、rs10516070及びrs955078からなる群より選択され、
　ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs1044043、rs10484565、rs241438、rs1800454、rs241429、rs241427、rs4711312、rs2071482、rs4148882、rs12529313、rs9276815、rs20547、rs9276825、rs9276832、rs241404、rs241403、rs3101942、rs241400、rs3132132、rs151719、rs1050391、rs9378127、rs188245、rs3129305、rs176248、rs12216336、rs2894311、rs12191230、rs2395301、rs12192713、rs12199692、rs1044429、rs592625、rs399604、rs365066、rs3763341、rs4713603、rs4713604、rs6936620、rs2116264、rs1367731、rs439852、rs446853、rs9296069、rs440841、rs3128952、rs3130180、rs3097662、rs3128955、rs3130588、rs9277183、rs3097669、rs9277194、rs376877、rs6457710、rs3077、rs9348904、rs9296073、rs2856816、rs3135021、rs1431403、rs9277542、rs3128963、rs3128965、rs3128966、rs3117229、rs2068204、rs2179920、rs2295120、rs3117242、rs3128921、rs3128923、rs9296079、rs3117230、rs3128930、rs872956、rs9380343、rs6937034、rs6937061、rs9277637、rs3117039、rs3130233、rs3117016、rs2395351、rs3116985、rs3129249、rs3129248、rs1003979、rs2071025、rs2855459、rs439205、rs213208、rs461338、rs458679、rs455567、rs14398、rs3130267、rs3130014、rs211455、rs211453、rs10807124、rs411136、rs2772376、rs7747216、rs9469491、rs17627049、rs210137、rs9296095、rs210138、rs444697、rs1794681、rs9469529、rs4711332、rs12205634、rs1408711、rs1536041、rs2229637、rs10947427、rs3818527、rs3818528、rs3818530、rs4713659、rs594223、rs7759668、rs626156、rs498114、rs654682、rs16869412、rs10947432、rs3818532、rs9394163、rs12203688、rs4713670、rs4713671、rs622917、rs12189725、rs877187、rs4713674、rs4713677、rs943466、rs943467、rs755495、rs747692、rs943475、rs6929696、rs3806108、rs3828783、rs3763253、rs9366829、rs9394169、rs4713686及びrs10947441からなる群より選択され、
　ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs1338657、rs9485685、rs9377361、rs9377365、rs9377366、rs9322660、rs9322661、rs2399802、rs17063309、rs680011、rs9499111、rs9404214、rs1569366、rs1569367、rs17443301、rs17063399、rs6906578及びrs7740643、並びにNCBI(v36.1)102984444からなる群より選択され、
　ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs1156490、rs6462540、rs1419842、rs2392267、rs1419803、rs1419805、rs1419809、rs6977125、rs17169769、rs17169771、rs7778512、rs1419840、rs35114106、rs1019089、rs16878925、rs1362172、rs2392270、rs17831435、rs10951417、rs1468559、rs10486643、rs6951496、rs7458608、rs2893480、rs4723375、rs1419863、rs1419864、rs9639694、rs9639695、rs10951418、rs10215667、rs6971556、rs12673387、rs4723377、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs12672624、rs10486649、rs2893482、rs12672538、rs10486650、rs2392274、rs2079509、rs10243426、rs2097960、rs1362173、rs1458549、rs450463、rs1023555、rs1023556、rs2530548、rs2530549、rs2530550、rs1419794、rs2530565、rs1458544、rs2609226、rs9792042、rs2530567、rs2609218、rs323925、rs323912、rs10239860、rs1419791、rs17777040、rs17198254、rs17777663、rs17777675、rs17198982、rs17788843、rs324978、rs324981、rs324983、rs1419780、rs325464、rs17199659、rs17789420、rs17789642、rs17170015、rs17200455、rs10263313、rs17790181及びrs11768189からなる群より選択され、
　ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs10277512、rs4720221、rs7787226、rs10951500、rs10274668、rs10255208、rs2006882、rs2392472、rs756507、rs2241152、rs7785934、rs7782979、rs17170754、rs3807162、rs3734948、rs741302、rs2041801、rs6966276、rs4723592、rs11769038、rs4723598、rs1882080、rs4723601、rs11982286、rs1986619、rs1882082、rs10268319、rs17170799、rs6957979、rs10225164、rs2293628、rs999744、rs17170820、rs17170826、rs17170830、rs1364373、rs13233995、rs6971267、rs7809487、rs1035582、rs2541103、rs2541074、rs2541075、rs2551069、rs1420421、rs6958656、rs10257460、rs12666532、rs1420422、rs17170915、rs10224438、rs7809365、rs6963276、rs6967358、rs6967403、rs10279544、rs4723619、rs17170955、rs2723969、rs6944921、rs6462746、rs1016321、rs2541082、rs4723631、rs2541089、rs2717975、rs10238916、rs2723952、rs12534004、rs2893540、rs2724006、rs2717983、rs2717990、rs2701004、rs2724007、rs2717992、rs2723996、rs9655380、rs2701003、rs2717993、rs2724003、rs2723980、rs2723990、rs2717948、rs2700992、rs6462758、rs2724014、rs2724016、rs1882079、rs2717954、rs13247953、rs2392495、rs10233634、rs12532031、rs4720246、rs7782999、rs1425124、rs1647801、rs2052688、rs2052687、rs10282309、rs10239693、rs17261508、rs10267165、rs918979、rs7777258、rs11767227、rs1647791、rs1732001、rs17171045、rs9655382及びrs6952260、並びにNCBI(v36.1)37495022からなる群より選択され、
　ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs12680471、rs2085640、rs17149989、rs17730481、rs17663071、rs17663167、rs4841147、rs1458938、rs1458939、rs11786942、rs17674819、rs1466338、rs13253327、rs17150066、rs11777274、rs11249921、rs17150087、rs1380104、rs11997346、rs4841156、rs6991328、rs17150131、rs7817148、rs10100760、rs17150181、rs17150185、rs17733293、rs7835349、rs7013746、rs7016636、rs3989158、rs17150211、rs4841169、rs4841171、rs6985564、rs11991621、rs4840426、rs6992432、rs10503380、rs7013834、rs6980831、rs12681719、rs4840427、rs4841179、rs7832096、rs4474027、rs4457339、rs12674762、rs4535743、rs1393、rs4342598、rs11780274、rs13273033、rs4841197、rs7010270、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs11785739、rs17150478、rs11787443、rs2898223、rs7820917、rs7829463、rs7000483、rs1567837、rs17734290、rs12540961、rs7829733、rs2137790、rs13249584、rs7013686、rs7015101、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996、rs7828229、rs17150703、及びrs531564からなる群より選択され、
　ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs12549261、rs10955436、rs6981257、rs11774921、rs11781710、rs1954724、rs6997025、rs1892764、rs16875775、rs11778352、rs2584372、rs2246255、rs2022958、rs2022949、rs16875901、rs1010824、rs2507799、rs10505100、rs11777978、rs16875983、rs9297393、rs7009229、rs13257393、rs4077322、rs11997995、rs10505105、rs4133396、rs4133395、rs4341141、rs10505107、rs11780324、rs35143736、rs17368715、rs17296616、rs17368821、rs10955450、rs1433178、rs2514850、rs1283653、rs2445351、rs1283659、rs16876122、rs1632130、rs1672143、rs16876200、rs2514867、rs1283706、rs1283703、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191、rs1298936、rs1368497、rs1529747、rs2916085、rs1368494、rs3847160、rs1654680、rs17301273、rs10086467、rs16876325、rs1283720、rs1433171、rs1433172、rs10216767、rs1583300、rs281708、rs10955457、rs10103715、rs281673、rs439896、rs281685、rs281696、rs2014769、rs281740及びrs190735、並びにNCBI(v36.1)108394240からなる群より選択され、
　ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs3869296、rs7020465、rs11142449、rs11142461、rs10868851、rs13439981、rs7039076、rs265083、rs2131355、rs265087、rs265073、rs7861495、rs10869020、rs17085775、rs11795256、rs10869034、rs1411992、rs10869043、rs12343877、rs11142941、rs869950、rs7046236及びrs9644996からなる群より選択され、
　ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs3012514、rs7846808、rs7027640、rs10781101、rs4526421、rs7853275、rs10869178、rs7864535、rs12004208、rs6560277、rs4573342、rs4132905、rs4073227、rs10121866、rs7044241、rs7855743、rs4373587、rs11143314、rs7047875、rs6560284、rs6560285、rs7857300、rs6560287、rs7866185、rs6560293、rs7026124、rs12346185、rs7041300、rs4307407、rs17095、rs10113863、rs7029452、rs6560297、rs7045535、rs13285932、rs10521449、rs13285999、rs10869190、rs9314799、rs1037031、rs2487471、rs2589623、rs2793153、rs2589615、rs969205、rs1796991、rs1838487、rs2589609、rs1663756、rs12351661、rs1663763、rs13298704及びrs2501914からなる群より選択され、
　ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs6479357、rs9409602、rs10991978、rs10991988、rs7867934、rs1388966、rs902923、rs902922、rs10512215、rs1532230、rs12337820、rs7029450、rs2131304、rs10992027、rs9299395、rs1388967、rs4073736、rs4073735、rs9409652、rs10992075、rs7031729、rs17585790、rs16907725、rs16907728、rs4372069、rs16907761、rs16907764、rs17586213、rs7039620、rs16907768、rs10992090、rs3802379、rs3935382、rs4601388、rs4744101、rs4743852、rs10119449、rs7858240、rs7022147、rs1569141、rs10992124、rs7856144、rs7855417、rs6479374、rs1881385、rs16907863、rs12002851、rs1881392、rs10992137、rs7045226、rs11789730、rs16907923、rs12684524、rs7858435、rs10116326、rs16907979、rs10992161、rs6479386、rs3858082、rs7038823、rs7871522、rs10125466、rs10992178、rs10820926、rs6479389、rs10820927、rs7867072、rs1954599及びrs10992207からなる群より選択され、
　ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs7022663、rs7024526、rs2289631、rs10986505、rs16927802、rs12001999、rs10819019、rs6478690、rs1017530、rs3824507、rs12352758、rs4838242、rs650599、rs7860360、rs2113352、rs7019234、rs7867749、rs2271746、rs16927930、rs10986618、rs10986626、rs12237026、rs463774、rs420423、rs10986641、rs10513445、rs393721、rs10819043、rs10986689、rs10986698、rs10986703、rs10986714、rs10986715、rs10986721、rs10986722、rs1463837、rs4837016、rs10126025、rs10986738、rs2819624及びrs3122938からなる群より選択され、
　ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs17306253、rs10887498、rs12243608、rs1876887、rs2457451、rs2664403、rs2664394、rs1912274、rs1912322、rs744413、rs2664406、rs2664405、rs2616673、rs2175200、rs2175201、rs17105725、rs1912277、rs2457450、rs17105747、rs746992、rs7076174、rs4027581、rs11201743、rs4418740、rs17105793、rs12221324、rs17105805、rs7924009、rs11201759、rs11201775、rs3011700、rs2949380、rs17105842、rs3011704、rs2140661、rs1917136、rs17105866、rs1880389、rs884316、rs2949384、rs2949385、rs2140666、rs2949386、rs1106789、rs11201804、rs17105912、rs17105916、rs2352181、rs947596、rs2352099、rs7924131、rs7923188、rs7923344、rs1418396、rs7899222、rs10788472、rs10887538、rs2153828、rs7910835、rs7914815、rs7918491、rs2001417、rs2001416、rs10887540、rs7095652、rs12773130、rs12779841、rs10887544、rs11201871、rs10887549、rs10788476、rs2003111、rs7912451、rs11201882、rs2352178、rs7923926、rs7082134、rs4284352、rs6585995、rs6585996、rs5003944、rs7923310、rs884700、rs4934156、rs11201909、rs868042、rs12257526、rs12262754、rs11817682、rs12243396、rs1870156、rs2607830、rs17320915、rs2814322、rs2607840、rs11201944、rs17106434、rs2607822、rs10887563、rs10887564、rs2492738、rs1870161、rs2607839、rs1870165、rs2814340、rs1902678、rs2814349、rs1947567、rs2168725、rs1902680、rs2607833、rs1902676、rs1896527、rs6586003、rs12262612、rs6586004、rs17106584、rs7905184、rs10887578、rs10509530、rs1078789、rs10749537、rs12355013、rs7904985、rs10788500、rs10788501、rs10458771、rs2018507、rs10887608、rs4934207、rs4934208及びrs7083506からなる群より選択され、
　ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs7124648、rs7128650、rs4587689、rs11039097、rs12796744、rs17197619、rs17790390、rs11039105、rs10501319、rs11039112、rs747650、rs7937410、rs17197710、rs1685404、rs2013867、rs901746、rs7118396、rs10838681、rs10501321、rs1051006、rs3816724、rs7124955、rs4752824、rs1052373、rs11570094、rs10769255、rs11039212、rs4992357、rs11605672、rs1534576、rs10742805、rs12419692、rs4752856、rs3817334、rs7120548、rs10838739、rs11039329、rs10742817、rs4752791、rs17788930、rs7114011、rs10838774、rs2305982、rs6485788、rs10838782、rs7924699、rs1872167、rs747782及びrs1681630からなる群より選択され、
　ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10896302、rs17615246、rs10750820、rs1945245、rs3938998、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs1945213、rs1945211、rs7113069、rs11228306、rs12785840、rs10501353、rs1945203、rs585475、rs615231、rs617315、rs675991、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594、rs634955及びrs613050からなる群より選択され、
　ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs1026250、rs10750931、rs7126121、rs11230241、rs10897026、rs12225299、rs10792264、rs7125753、rs11605188、rs1899571、rs11230258、rs11230261、rs7943967、rs4442568、rs10897047、rs2868121、rs7945665、rs10897049、rs4506675、rs10792267、rs2304935、rs2165832、rs10736703、rs4939347、rs2233244、rs950803、rs950802、rs3816270、rs2241920、rs10501383、s10897056、rs4939352、rs955019、rs4938943、rs11230304、rs3763850、rs2282524、rs10897061、rs2120182、rs12787520、rs4146870、rs4939364、rs1051756、rs1941032、rs17615252、rs17543397、rs8181503、rs7946021、rs4939391、rs2186919、rs2847222、rs2633277及びrs2847212、並びにNCBI(v36.1)59954904からなる群より選択され、
　ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs565976、rs534179、rs2276443、rs532454、rs511190、rs566818、rs482458、rs1793412、rs1790149、rs1790155、rs1790154、rs668727、rs11600640、rs611449、rs11236449、rs661928、rs621305、rs11236452、rs7128888、rs7129014、rs688727、rs674503、rs606452、rs11236458、rs599816、rs660343、rs541993、rs601142、rs648930、rs611221、rs12574551、rs584046、rs640927、rs11236476、rs17134231、rs12282340、rs10160335、rs12281880、rs656007、rs479592、rs589443、rs4944086、rs10751245、rs7110142、rs7947980及びrs509530、並びにNCBI(v36.1)75005360からなる群より選択され、
　ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs17120344、rs6589597、rs10790175、rs12420127、rs10892082、rs7107152、rs1242229、rs1784042、rs2269399、rs526602、rs664971、rs11216315、rs1263499、rs17120523、rs236919、rs528508、rs593245及びrs477036、並びにNCBI(v36.1)116617736からなる群より選択され、
　ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs7297299、rs5745807、rs5745811、rs9739560、rs4767654、rs10638、rs9788041、rs11068799、rs11068803、rs10850953、rs7135008、rs11613924、rs7307331、rs9669474、rs7957463、rs10850956、rs2936840、rs904661、rs1726407、rs1726392、rs17440336、rs1277442、rs11068860、rs11068865、rs17512142、rs17440364、rs364823、rs418941、rs7974718、rs11068891、rs16948230、rs404566、rs16948234、rs17512483、rs17512574、rs2271007、rs11068937、rs7966814、rs6490178、rs905579、rs983421、rs1503767、rs7132650及びrs7316050からなる群より選択され、
　ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7964173、rs11061064、rs10848174、rs7965385、rs7979388、rs7953972、rs4759749、rs4759751、rs7308461、rs1881062、rs10083153、rs729463、rs1881067、rs2695872、rs10848193、rs10848194、rs7305915、rs2398529、rs3864899、rs4412792、rs2632601、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483、rs1609985、rs10848218、rs11061198、rs7307055、rs11061209、rs10773833、rs11061222、rs7299940、rs2141182、rs1405904、rs1316893、rs4074922及びrs4388928からなる群より選択され、
　ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs9521809、rs4773201、rs1106649、rs9521814、rs385037、rs7997619、rs912941、s1886871、rs2182271、rs912942、rs331596、rs9559844、rs331602、rs1536621、rs9521853、rs9559849、rs7999854、rs3858821、rs4771696、rs4773228、rs4773229、rs2765341、rs3742193、rs3742194、rs7323602、rs3759463、rs179356、rs330565、rs7394、rs389656、rs450514、rs445490、rs418321、rs2251314、rs2165418、rs7999702、rs9521926、rs3098728、rs9515279及びrs2582886、並びにNCBI(v36.1)110097814からなる群より選択され、
　ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs6493469、rs12595526、rs8031702、rs17599974、rs16953045、rs10744956、rs2306335、rs6493470、rs7181201、rs11856609、rs1124769、rs17647040、rs12899586、rs12904155、rs7170455、rs7177664、rs8040954、rs17647084、rs4775916、rs1111266、rs16964077、rs1025738、rs7179084、rs7176579、rs16964113、rs10519293、rs17522553、rs12324478、rs1075681、rs2899469、rs8031580、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs16964201、rs12595627、rs8023263、rs2899473、rs700518、rs3759811、rs17703883、rs1865803、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs1062033、rs2008691、rs11636403、rs10519299、rs17647707、rs17647719、rs7167343、rs936308、rs12594203、rs999480、rs2290622、rs8031463、rs6493495、rs2445765、rs2445766、rs2445768、rs1551656、rs12441382、rs2446420、rs2124873、rs2470184、rs2470187、rs2445781、rs12595284、rs17647970、rs7174434、rs764530、rs12438104、rs16964308、rs4775942、rs16964316、rs2470172、rs2470173、rs16964319、rs10163098、rs12443092、rs2168623、rs3751586、rs2445741、rs8036694、rs2459396及びrs16964348、並びにNCBI(v36.1)49383121からなる群より選択され、
　ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs4399573、rs12051837、rs6504736、rs7208167、rs9303589、rs1468118、rs10491154、rs17695254、rs2073864、rs9912472、rs3764798、rs17695921、rs11867674、rs886078、rs8076197、rs8076496、rs2073866、rs9901183、rs4794293、rs8064617、rs4794294、rs985758、rs4794295、rs16950363、rs2873938、rs1263962、rs1263965、rs1263988、rs1263989、rs4794298、rs4794300、rs8080331、rs11869209、rs1269480、rs1263978、rs1003290、rs1263981、rs1405191、rs1263984、rs9904076、rs4794304、rs8074185、rs6504747、rs16950512、rs7223782、rs4794305、rs16950534、rs1526182、rs1501255、rs4496207、rs1125750、rs1405187、rs767326、rs981577、rs4794307、rs202133、rs16950626、rs9896969、rs202136、rs202121、rs202120、rs203076、rs203090、rs203092、rs203093、rs203097、rs203098、rs10514990、rs203010、rs10514991、rs203022、rs6504754、rs12603762、rs169386、rs203042、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs203002、rs1005092、rs9896168、rs8065627、rs16950939、rs2907784、rs11079991、rs1393735、rs2970016、rs1875675、rs2938139、rs1354275、rs7224915、rs9893317、rs1503059、rs2970052、rs11655715、rs1155218、rs2931368、rs2931365、rs2931364、rs9908649、rs1486745、rs4605214、rs1503041、rs10514997、rs10514998、rs11079993、rs1503050、rs1503051、rs10515000、rs12949235、rs1393734、rs17678475、rs16951169、rs12150128、rs16951176、rs16951177、rs9903651、rs10515001、rs1847245、rs12150499及びrs6504764からなる群より選択され、
　ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs8086948、rs12457951、rs11151371、rs17077389、rs1480679、rs5000099、rs1480682、rs433411、rs370944、rs395074、rs379982、rs281571、rs1444106、rs2448716、rs1562072、rs1867412、rs17077583、rs764133、rs17828615、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112、rs2448755、rs2448745、rs2440527、rs28379561、rs10503118、rs1562070、rs2448727、rs17077858、rs12605273、rs2440540、rs4127445、rs7231324、rs12964913、rs9319739、rs17077963、rs12954315、rs4127447、rs7243836、rs8085641、rs2054299、rs515540、rs519360、rs17078114、rs2613163、rs652082、rs638006、rs3911662、rs12966846、rs3845265、rs11661918、rs11151403及びrs9953435からなる群より選択され、
　ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs1884029、rs6072606、rs2207220、rs4812571、rs4572656、rs2013923、rs4812574、rs6513762、rs6513763、rs6029950、rs2144009、rs2866941、rs6102658、rs2144011、rs3787282、rs746413、rs4812578、rs6102671、rs1126101、rs6065434、rs4810352、rs1076666、rs6029980、rs6016688、rs2076249、rs17221018、rs17221067、rs17312515、rs17221137、rs6130047、rs16986551、rs17221326、rs16986558、rs12625871、rs6016698、rs6030014、rs17221823、rs1883377、rs6016705、rs2179336、rs2143008、rs6030030、rs2206169、rs6102713、rs6093598、rs6030070、rs6030071、rs1014757、rs2143632、rs6030076、rs16986712、rs727337、rs727336、rs6030096、rs11906485、rs2867026、rs16986733、rs11698118、rs6124439、rs11696306、rs1016071、rs6030124、rs1573707、rs6016745、rs12481463、rs4812588、rs6102795、rs11697499、rs4812591、rs916327、rs1883269、rs16986850、rs1033414、rs11700137、rs6072747、rs999114、rs999113、rs6016798、rs2076082、rs6065482、rs6065484、rs6065487、rs6130145、rs230153、rs230154、rs172981、rs230155、rs6072758、rs230157、rs6124468、rs6102880、rs6130153、rs6065504、rs6065509、rs6072789、rs1033643、rs13040647、rs16987042、rs6030322、rs6072792、rs4482557、rs6130168、rs6030341、rs17747544、rs6065515、rs1883843、rs8119203、rs10854226、rs6102929、rs8121443、rs6030363、rs6102950、rs2867488、rs7360934、rs909863、rs6030370、rs6030380、rs6030381、rs9974028、rs6093705、rs6030385、rs6102967、rs2223542、rs6030395、rs6065520、rs6072814、rs2206426、rs6016864、rs6072819、rs6030407、rs6065525、rs2425520、rs2425530、rs4812631、rs4810366、rs2017914、rs3092557、rs17749109、rs4812637、rs6030442、rs6030443、rs1018407、rs6016884、rs1022819、rs733976、rs6030456、rs6093729、rs6030462、rs17749217、rs2146615、rs8119733、rs13042473、rs6103041、rs1973949、rs208256、rs208254、rs3092043、rs2077768、rs208250、rs4812645、rs6130222、rs4812655、rs6130232、rs208230、rs208229、rs6065544、rs6065545、rs6065546、rs7262282、rs7262355、rs11699742、rs8125304、rs6065547、rs4812659、rs16987493、rs208272、rs208273、rs4315585、rs208186、rs208197、rs206636、rs6030572、rs4812664、rs4812665、rs16987668、rs206148、rs206154、rs206159、rs206163、rs2208048、rs2425546、rs2425553、rs2425554、rs2425560、rs2425562、rs1106978、rs6030634、rs6016951、rs1006746、rs2425587、rs927058、rs2425593、rs2425599、rs2425610、rs16987770、rs6016963、rs6065579、rs1572929、rs6072998、rs6030670、rs947202、rs947203、rs4812681、rs6093784、rs4812683、rs10485698、rs926288、rs1569445、rs6030689、rs2867656、rs11699547、rs6030709及びrs7267873、並びにNCBI(v36.1)40130174からなる群より選択され、
　ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs12626309、rs2834231、rs4817579、rs2834238、rs2211689、rs2834246、rs2834251、rs2834252、rs1537097、rs1892589、rs2073368、rs2409499、rs9978415、rs2268247、rs9979937、rs2834264、rs2834268、rs879261、rs2245099、rs1108000、rs9979150、rs743316、rs2300384、rs3746861、rs2834292、rs2834295、rs2040113、rs2834296、rs2834297、rs2239565、rs17655810、rs12626410、rs2834303、rs2236645、rs2834310、rs16991110、rs2070513、rs2032312、rs2032313、rs2834315、rs11088265、rs17730050及びrs2834332からなる群より選択され、
　ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs13416802、rs2287616、rs2287613、rs3770597、rs10200158、rs6761690、rs13430236、rs3814381、rs4148765、rs10490134、rs11902639、rs10183805、rs13403114、rs3815574、rs2302698、rs6750251、rs4667590、rs4668121、rs1990702、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs11679947、rs10490132、rs2239602、rs2024481、rs741378、rs2284679、rs4287730、rs10210408、rs1548936、rs3770604、rs2075248、rs10490131、rs10169232、rs2239600、rs2284675、rs2268373、rs2268372、rs2193193、rs2268370、rs6747692、rs2300445、rs2239598、rs2239597、rs2239596、rs2239594、rs830957、rs830959、rs12988804、rs831002、rs16856748、rs11887007、rs16856759、rs830964、rs830971、rs830972、rs2247506、rs3845731、rs3770636、rs2673172、rs6713072、rs1990842、rs10199676、rs830955、rs12616998、rs12613663、rs10930354、rs4281872及びrs12052892からなる群より選択され、
　ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs523246、rs10501136、rs836950、rs12808574、rs10836315、rs502857、rs731726、rs731727、rs967751、rs1553760、rs1396880、rs2941043、rs2941042、rs2941061、rs2956079、rs2941054、rs1509662、rs2941052、rs2915234、rs891550、rs919554、rs2915232、rs2956086、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986425、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs984690、rs3763934、rs10488801、rs2956106、rs11032927、rs2915202、rs2915201、rs2915199、rs1998912、rs2915193、rs11032937、rs2915227、rs2732557、rs10836326、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs1409716、rs2762955、rs952489、rs514182、rs1425806、rs2732528、rs2553794、rs2553793、rs678137、rs2785156、rs2553787、rs737503、rs737502、rs2162159、rs2732552、rs387619、rs10836332、rs353610、rs353605、rs2785189、rs2553822、rs11032995、rs12291631、rs353590、rs353589、rs353587、rs1559759、rs4756190、rs353581、rs7106681、rs507230、rs634096、rs2732578、rs404977、rs4756191及びrs2785180からなる群より選択され、
　ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs7979656、rs10849918、rs2106407、rs2106406、rs12425190、rs11065783、rs2339706、rs4509829、rs7961663、rs4766526、rs4766442、rs4766443、rs12815195、rs12229654、rs756825、rs16941284、rs6489979、rs4766553、rs9783423、rs7952972、rs16941319、rs3809290、rs7962233、rs4766451、rs886126、rs2078851、rs1265566、rs2301658、rs7300082、rs7300860、rs16941414、rs7398833、rs16941437、rs10849946、rs2078863及びrs11065898からなる群より選択され、
　ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs2332297、rs2934884、rs16955216、rs2934890、rs7225247、rs16955225、rs9303359、rs7207731、rs17683089、rs11658131、rs2958944、rs2934909、rs2934914、rs2934921、rs2958933、rs7221313、rs7210248、rs2958921、rs8079105、rs16955327、rs12949718、rs9899602、rs17745123、rs8070668、rs9910653、rs17817829、rs12936860、rs12951898、rs17817950及びrs2787501、並びにNCBI(v36.1)50344775からなる群より選択される（１）の検査方法。 (2) The polymorphic site in the region containing ELOVL5 of human chromosome 6 is a single nucleotide polymorphism international number rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730, rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs1429146, rs9463895, rs2235146, rs9463895, rs2235146 rs6909592, rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517, rs9370201, rs9367529, rs12209741, rs7744451, rs6904083, rs6904376, rs9367532, rs2067 347 selected from the group consisting of rs622447, rs3736729, rs13212365 and rs761141;
The polymorphic site in the region containing SRBD1 of human chromosome 2 is a single nucleotide polymorphism international number rs11686431, rs7580559, rs3908093, rs2343412, rs12623996, rs7573149, rs918810, rs6721199, rs7579209, rs10194925, rs17033378, rs2343466, rs17033398, rs6737172, rs4953226 , Rs3851333, rs12473388, rs11681887, rs35608719, rs11888802, rs11678872, rs2343468, rs13003019, rs6760244, rs12471726, rs2081297, rs10460504, rs7562458, rs4953230, rs4952763, rs6719211, rs1014454, rs3753770 , Rs3770264, rs10205197, rs10427308, rs17033745, rs3770278, rs17322370, rs6736954, rs10427402, rs4476395, rs13023749, rs17033801, rs755652, rs748573, rs6708810, rs6710581, rs12712945, rs17033871, 686, rs65440840 , Rs1517001, rs1522988, rs614281, rs582213, rs650508, rs666334, rs17033965, rs556650, rs22 04204, rs3795863, rs2285024, rs505310, rs10490342, rs612717, rs10490341, rs656823, rs563601, rs609573, rs6746467, rs637889, rs10495926, rs1522986, rs1522987, rs6544843 and rs6724488,
Polymorphic sites in the region containing ARPP-21 of human chromosome 3 are single nucleotide polymorphism international numbers rs1523048, rs1523029, rs12487524, rs1403468, rs872133, rs1523040, rs1523041, rs13069451, rs12629480, rs1357449, rs6801949, rs17033355, rs9873254, rs9839823 , Rs6794354, rs6794373, rs12637211, rs9855328, rs2037538, rs2037539, rs1523038, rs11718271, rs1608314, rs2197728, rs9311101, rs10490870, rs17033506, rs12634096, rs2359774, rs9860326, rs4678788, rs3213953, rs321393 167 Rs17280201, rs6779091, rs3772395, rs9872664, rs1963934, rs35102908, rs4678802, rs4678803, rs6550367, rs17033738, rs6801590, rs17033748, rs9865772, rs17033755, rs17228111, rs2016955, rs2016975, rs13781, rs11920715, 149 , Rs6799609, rs17033836, rs4234248, rs6770245, rs10865865, rs7615307, rs9845811, rs17033961, rs1488092 , Rs10461001 and rs17033999,
Polymorphic sites in the region containing EPHA5 of human chromosome 4 are single nucleotide polymorphism international numbers rs371925, rs4241661, rs170654, rs1514271, rs2063419, rs13102419, rs11131589, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs4860651 , Rs11938753, rs1376417, rs10025570, rs1376416, rs2084682, rs7658065, rs9312144, rs1376412, rs17086181, rs17086185, rs6847413, rs2198103, rs12509018, rs17082122, rs6823779, rs17086224, rs1451170, rs4289492, rs8601 Rs4365778, rs7673091, rs4320185, rs4604104, rs7684022, rs4860679, rs6844942, rs12644315, rs4599467, rs6834811, rs4320186, rs4487412, rs7667410, rs4611975, rs4370201, rs4438803 and rs4608860,
The polymorphic site in the region containing GMDS of human chromosome 6 is a single nucleotide polymorphism international number rs11966212, rs2143396, rs6911992, rs9378593, rs9392253, rs9378594, rs2050158, rs9391900, rs6596786, rs2235706, rs9378596, rs1997773, rs6926322, rs7754106, rs7750178 , Rs742520, rs2210370, rs6940618, rs349100, rs9405444, rs6932005, rs4959523, rs10484953, rs464778, rs115705, rs1013185, rs11242672, rs463641, rs4959525, rs369656, rs459162, rs127091, rs4639519, rs463264, rs775742 Rs238050, rs9378605, rs2459602, rs2438074, rs12191625, rs2438077, rs2496292, rs2496301, rs2438083, rs977674, rs977673, rs17259747, rs1437288, rs7772349, rs6596805, rs1347656, rs6925983, rs1550199, rs4159, rs4 , Rs9405137, rs9405471, rs746095, rs9378623, rs9378292, rs1711957, rs7742720, rs9378629, rs7741690, rs9328052, rs9328053 rs1922938, rs2745636, rs2816242, rs932410, rs1474721, rs9392296, rs9502950, rs6907725, rs9405484, rs4443540, rs4355648, rs9328058, rs9328059, rs2569866, rs6935712, rs6935896, rs6937266, rs16, rs16 rs2745567, rs2493160, rs2317966, rs9392305, rs9501738, rs2569839, rs9328061, rs9378300, rs2816221, rs6916316, rs2281272, rs2569824, rs9405496, rs1810496, rs2814827, rs7759035, rs9502997, rs2814811, rs231794, 937 rs9405505, rs9503015, rs9501762, rs9405506, rs12197419, rs7765344, rs7765461, rs1013303, rs3800046, rs689035, rs2318108, rs6919059, rs6928276, rs226456, rs9378314, rs1157673, rs1157675, rs9398073, rs3380 rs6596858, rs9378661, rs3823279, rs3800122, rs10484693, rs17772389, rs4959160, rs3778555, rs4463305, rs3800140, rs17134506, rs3800142, rs3800143, rs3800144, rs3800146, rs2761234, rs9405156, rs17134549, rs1408002, rs1830733, rs1830734, rs10223785, rs9405157, rs7772545, rs6596866, rs4959611, rs413269, rs4412249 rs4580917, rs6910252, rs11242733, rs9503080, rs11242735, rs476594, rs9378676, rs676015, rs2026446, rs4959631, rs17134693, rs3800156, rs11242740, rs4959635, rs3800159, rs3778557, rs3800168, rs4959643, rs234930, rs9393 690 rs3778568, rs9405550, rs17134819, rs3823287, rs1196396, rs1684153, rs9328087, rs2479003, rs2479004, rs2505678, rs2479008, rs2505674, rs7766115, rs4959648, rs4413658, rs7449538, rs9503158, rs6902156, rs6925636, rs6925636, rs6925636, rs6925636 rs13200914, rs17135028, rs4959184, rs11242770, rs9328099, rs12206851, rs6904395, rs176 09498, rs742487, rs4959185, rs9391949, rs9391950, rs6899721, rs1610416, rs3924452, rs10458144, rs9501850, rs9503199, rs4959677, rs35374935, rs2449448, rs1772982, rs1680885, rs2794569, rs2624936, rs21969936, rs12196957, rs262416 selected from the group consisting of rs2624916 and rs6899711,
Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 are single nucleotide polymorphism international numbers rs2248373, rs2248459, rs2248462, rs2248617, rs3749946, rs2523650, rs2904776, rs2516422, rs2905747, rs9267247, rs2395034, rs3095229, rs3131631, rs2516486, rs2734573, rs3115537, rs2516478, rs2071593, rs3219183, rs13215091, rs1799964, rs1052248, rs9348876, rs2857697, rs2736172, rs1046089, rs2255741, rs760293, 8052 rs, rs3130048, 805 rs707974, rs805268, rs805267, rs9378164, rs707918, rs805292, rs2299851, rs707939, rs707937, rs480092, rs2075800, rs2763979, rs11965547, rs486416, rs6444045, rs537160, rs2072633, rs522162, rs550513, rs9296003, selected from rs406936 and rs492899
The polymorphic site in the region containing SYTL3 of human chromosome 6 is the single nucleotide polymorphism international number rs602698, rs678116, rs649930, rs643677, rs592698, rs675053, rs612364, rs629364, rs627967, rs628203, rs2771425, rs9355655, rs10499309, rs1041566, rs12530454 , Rs7753885, rs9347236, rs6455585, rs6931414, rs10447366, rs9457403, rs9355246, rs4709219, rs4708797, rs4709226, rs4709235, rs6925091, rs3799195, rs6913912, rs894124, rs6903405, rs6901469, rs9364496, rs7756009, rs7756009 Rs3102970, rs6455604, rs3127188, rs3127194, rs3127196, rs3102966, rs3127168, rs923198, rs6924755, rs2361472, rs4569991, rs9457516, rs9456363, rs9365009, rs3923902, and rs12207795,
Polymorphic sites in the region containing NXPH1 of human chromosome 7 are single nucleotide polymorphism international numbers rs3807826, rs7802863, rs3757521, rs3757520, rs3807823, rs1861032, rs17145870, rs7805508, rs6977682, rs3807815, rs1008038, rs3807811, rs11769978, rs3779356, rs3807 , Rs3807806, rs7455929, rs6463790, rs4620183, rs12668479, rs17147407, rs11762595, rs12702719, rs17147608, rs12154895, rs17403198, rs16873367, rs42949, rs2349188, rs6463805, rs7811039, rs10247446, rs10270530, 450, rs7795564, rs , Rs17149337, rs17404218, rs11976158, rs10244689, rs6978212, rs757704, rs2214694, rs2189904, rs765855, rs17150199, rs10261060, rs4401754, rs10266489, rs5018942, rs4556000, rs10278603, rs7787432, rs6959052, rs17150410, rs150479 , Rs1859274, rs10238726, rs6970999, rs17151821, rs7456267, rs6963180, rs10257265, rs970526 rs977458, rs13240427 and rs17154007, and is selected from the group consisting of NCBI (v36.1) 8484291,
The polymorphic site in the region containing LHFPL3 of human chromosome 7 is the single nucleotide polymorphism international number rs41521, rs2188486, rs977641, rs17389507, rs10274138, rs17136882, rs13234807, rs7794181, rs7787988, rs7787976, rs17331134, rs1557689, rs6465984, rs7798273, rs2188 , Rs1468143, rs10953427, rs2214087, rs4730006, rs6952170, rs17137313, rs4727599, rs17137382, rs10228106, rs42181, rs4730010, rs11763758, rs17137711, rs11763095, rs6977743, rs4520098, rs10216261, rs11972050, rs12539136, rs756, rs12539136, rs756 , Rs6949801, rs9987005, rs6465994, rs6465995, rs6465995, rs1477110, rs12216618, rs10254402, rs6969323, rs9641335, rs10272959, rs3919550, rs4730030, rs10246540, rs4730031, rs2891730, rs995661, rs10487221, rs19833, rs11773248, rs1 , Rs17269890, rs4730038, rs4584085, rs10216010, rs17141284, rs17141299, rs10953450, rs6466018, rs45309 75, rs12705276, rs4283980 and rs2470965, and NCBI (v36.1) 103849313, 104068646 and 104196627,
The polymorphic site in the region containing GLB1L3 of human chromosome 11 is the single nucleotide polymorphism international number rs11223704, rs470713, rs470935, rs641024, rs11606866, rs7131644, rs10894784, rs1031381, rs522134, rs4362160, rs473041, rs498602, rs554874, rs1144225, rs1595895 Rs1146192, rs4936229, rs1144219, rs2510356, rs553231, rs512359, rs568044, rs10894798, rs10894799, rs11223765, rs10894800, rs79940114, rs10894801, rs10791357, rs3741100, rs3741098, rs7113199, rs1866769, and rs13866768 and rs13866768
The polymorphic site in the region containing ZNF407 of human chromosome 18 is a single nucleotide polymorphism international number rs3794941, rs17055278, rs514931, rs494721, rs17055426, rs2896769, rs12717033, rs7227977, rs10871527, rs10514139, rs17832851, rs17055756, rs14732224, rs8085262 Rs8089151 , Rs10871567, rs7242893 and rs7239800,
The polymorphic site in the region containing PAX7 of human chromosome 1 is a single nucleotide polymorphism international number rs3000058, rs2816030, rs16862061, rs2816040, rs2816046, rs4920334, rs4920516, rs4920335, rs2816064, rs6704504, rs1934057, rs2298893, rs2743208, rs2076021, rs2076020 Rs2236826, rs2282704, rs2282699, rs624761, rs851123, rs2236817, rs685300, rs2056446, rs2841078, rs4920344, rs6669544, rs4076925, rs6603910, rs11261070, rs7539659, rs11261074, rs7411058, rs49195545, and rs66819577
The polymorphic site in the region containing PTPRF of human chromosome 1 is a single nucleotide polymorphism international number rs2494997, rs1999674, rs2842180, rs2255632, rs2251804, rs1334973, rs6687571, rs2039528, rs2819341, rs10890251, rs2367617, rs11210864, rs2782641, rs11210871, rs10890257 Rs12058744, rs11210879, rs11210886, rs11210886, rs516790, rs641365, rs673485, rs643445, rs10789438, rs11210892, rs617521, rs660899, rs2274465, rs10789439, rs489319, rs607062, rs10789442 and rs3791035, and NCBI (v36.1) 43760103,
The polymorphic site in the region containing 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 is a single nucleotide polymorphism international number rs2355388, rs6686200rs12122453, rs12122534, rs4950474, rs4950475, rs6593810, rs6657631, rs21327, rs517201, rs575115, rs2031481, rs2477568, rs2477569, rs692963, rs69358, rs535827, rs4950361, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs2077749, rs17159914, rs6593 rs6703187, rs10793652, rs7537483, rs7537703, rs1890038, rs3820130, rs3737845, rs17160062, rs3766525, rs4950315, rs17356240, rs10494244, rs6683839, rs10793656, rs17360443, rs3753433, rs12033407, rs3684, rs36837, rs36837 rs17360812, rs6656156, rs12759145, rs12049491, rs10793682, rs4950431, rs7539416, rs2353969, rs4504949, rs17160205, rs2353967, rs1 2728058, rs6688308, rs11589438, rs6688154, rs6678706, rs4950436, rs41989436, rs7519891, rs11240053, rs11240054, rs11240055, rs7556087, rs7518276, rs2644579, rs2353951, rs2644577, rs6674761, rs2644566, rs2803535, rs17160256, rs1258 selected from the group consisting of rs17160305,
The polymorphic site in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1, the single nucleotide polymorphism international numbers rs10752613, rs11583896, rs16835600, rs4434872, rs4363451, rs9427232, rs4845576, rs4520447, rs4845578, rs11585416, rs4845584, rs12033835, rs11581644, rs10908557, rs6701341, rs2297898, rs12048137, rs11264875, rs2066134, rs2494663, rs6671166, rs4845600, rs19853584, rs19853584 rs1212352, rs6672010, rs6702754, rs2274988, rs2297607, rs4414034, rs6696089, rs11265607, rs6427631, rs6427658, rs6694817, rs4537545, rs4845626, rs11265618, rs10752641, rs4240872, rs4474240, rs6700290, rs12126564, rs12126564, rs12126564, rs12126564 rs1127314, rs1127313, rs2131902, rs2229857, rs3766923, rs3766922, rs12125166, rs2335230, rs7531982, rs7533471, rs11264233, rs10796927, rs2335252 rs2036627, rs6699979, rs1995662, rs6664817, rs11264249, rs6426905, rs960182, rs16836320, rs868108, rs4845390, rs10494300, rs1051614, rs6666341, rs11808053, rs883319, rs1777910, rs951240, rs9970364, rs1984285, rs9970364, rs1984285 rs4845679, rs4845681, rs12130132, rs10908448, rs4845690, rs4845406, rs10908455, rs7368345, rs10908456, rs4971079, rs4276913, rs11264339, rs3768566, rs11264345, rs7520184, rs12032720, rs11264359, rs1126411, rs9085, rs rs822508, rs1749405, rs1749409, rs572609, rs3768280, rs2275078, rs2016251, rs1475766, rs12035615, rs4661146, rs6700693, rs10908489, rs11264449, rs2253677, rs2241110, rs2853641, rs2075163, rs3 520, rs1052053, rs1067, rs1052053, rs1067 rs2287023, rs2246476, rs2248273, rs11264467, rs7522860, rs10908500, rs10494304 rs3795730, rs3762281, rs35478936, rs2274226, rs2985714, rs2842854, rs954916, rs6686886, rs11590409, rs4661040, rs7551781, rs16837376, rs11806983, rs1109751, rs11264486, rs3790458, rs1342441, rs12136856, rs1015911, rs12136856, rs10159180, rs12136 selected from the group consisting of rs879461, rs12742817, rs3795736, rs2236601, rs1046650 and rs3795737,
The polymorphic site in the region containing FAM5B and / or ASTN1 of human chromosome 1 is a single nucleotide polymorphism international number rs7521610, rs16850728, rs227521, rs227519, rs10047146, rs10489307, rs972484, rs1402640, rs10913291, rs12094495, rs10254503, rs6425414, rs7515582 Rs10913294, rs7534953, rs10913295, rs725416, rs12090000, rs12564343, rs12031932, rs12079554, rs554454, rs6660903, rs10913300, rs760689, rs6683060, rs926319, rs6699955, rs10798508, rs2139876, rs16851037, rs17315188, rs2862 , Rs3946142, rs6658794, rs9425456, rs6672376, and rs12025407,
The polymorphic site in the region containing PKP1 of human chromosome 1 is a single nucleotide polymorphism international number rs1122396, rs1722755, rs6413916, rs831771, rs1404401, rs831767, rs16847944, rs831765, rs16847947, rs831764, rs16847951, rs831762, rs831753, rs16847994, rs831751 Rs4915220, rs10157719, rs947379, rs12466, rs1592085, rs4915499, rs12134467, rs10158798, rs1954214, rs12046907, rs10920161, rs12117501, rs1997018, rs1880450, rs1857489, rs16848184, rs868381, rs854488, rs832169, rs832174 , Rs854502, rs1722780, rs1779293, rs854505, rs1572968, rs17425876, rs12143423, rs947377, rs10753899, rs17459837, rs6427900, rs1122481, rs2275862, rs11806184, rs2365652, rs2275860, rs947485, rs6671395, rs1256941, rs10875 And rs12090950,
The polymorphic site in the region containing KLHL29 and / or FLJ14126 of human chromosome 2 is a single nucleotide polymorphism international number rs2577720, rs2723120, rs10495742, rs2577717, rs6720565, rs12053097, rs12613333, rs7566157, rs17045229, rs875077, rs17045238, rs2723129, rs2577698 , Rs2954818, rs12989910, rs11125011, rs6742888, rs7564616, rs2723111, rs6544822, rs893430, rs737564, rs737565, rs747344, rs6727901, rs7570872, rs17045350, rs6544861, rs6756357, rs4665214, rs10172684, rs1653748, 808646 Rs10490750, rs11677730, rs7601971, rs1653751, rs1653753, rs1368081, rs11678782, rs11678785, rs4497835, rs1653780, rs17445645, rs4665223, rs4284788, rs4665612, rs1709339, rs6544949rs17045574, rs6543966, rs4665230, rs4168 , Rs13386930, rs6721623, rs3795933, rs7560892, rs4233701, rs9261, rs7579413, rs12470949, rs124787 Selected from the group consisting of 01, rs2081302, rs12478744, rs2339853 and rs35379186,
Polymorphic sites in the region containing THRB of human chromosome 3 are single nucleotide polymorphism international numbers rs1397878, rs6765461, rs6801153, rs1464010, rs7630879, rs6550848, rs826375, rs1667765, rs826378, rs6808673, rs2596623, rs17194828, rs1562736, rs9310730, rs2683535 , Rs7652337, rs7652444, rs2683542, rs1667739, rs1505302, rs6799431, rs17014338, rs826249, rs10510540, rs6772213, rs851719, rs6792783, rs1354605, rs866651, rs958892, rs826225, rs6550853, rs8261, 4491 417 , Rs1449872, rs9849581, rs9863517, rs9843698, rs9867989, rs1667746, rs17787319, rs1505307, rs7640580, rs12639035, rs9810037, rs9833191, rs12630454, rs3951794, rs6781111, rs1505287, rs12495379, rs44953 Rs4858617, rs4858618, rs2196427, rs10490840, rs6788339, rs6765048 and rs892941
The polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 is a single nucleotide polymorphism international number rs13088412, rs9837084, rs744876, rs571170, rs358954, rs9833515, rs6440716, rs358967, rs1993404, rs9883677, rs2048229 Rs16863149, rs891666, rs1835668, rs6787683, rs16863204, rs16863208, rs16863229, rs3732755, rs3773614, rs1231521, rs3108727, rs3773619, rs7649855, rs16863264, rs2870518, rs3846072, rs188391, rs1882014, rs1686395, rs1881 , Rs7623356, rs1491981, rs6440735, rs3971192, rs7644001, rs16863323, rs6801273, rs9820422, rs16863336, rs1388622, rs3975404, rs10513394, rs6787801, rs9289836, rs3821663, rs7429509, rs3821664, rs1491974, rs9653954, rs965501 , Rs11709550, rs3732769, rs10935844, rs2276765, rs2276766, rs16863376, rs6440741, rs6771904, rs6772196, rs3732771, rs9864533, rs4435614, rs17204557, rs6798252, rs4680440, rs4680443, rs13088575, rs6790903, rs9289840, rs4680474, rs4541381, rs4596123 and rs7612205, and NCBI (v36.1) 152200518, 152229595, 152456055 and 152609183, selected from the group
Polymorphic sites in the region containing SORBS2 of human chromosome 4 are single nucleotide polymorphism international numbers rs10866277, rs12645545, rs12649063, rs7437897, rs11132327, rs10866278, rs6823490, rs6843640, rs6818789, rs2101307, rs6552895, rs6552896, rs6552897, rs12498673, rs10025 , Rs2306707, rs3749579, rs6848934, rs2306703, rs11934819, rs4862558, rs4599460, rs4862559, rs6823546, rs11132334, rs5018568, rs904451, rs7677363, rs2030144, rs11132338, rs11132340, rs7669883, 132, rs1027521, rs1027521, rs1027521 , Rs10024805, rs6834923, rs6812818, rs10015164, rs11132345, rs10024359, rs10000785, rs1039235, rs2310357, rs10028428, rs4862571, rs7684943, rs10021308, rs1566347, rs12504307, rs11132355, rs10028944, rs149904, rs117307 , Rs4861686, rs1026362, rs12643549, rs2310372, rs4862588, rs10031442, rs4637445, rs194745 5, selected from the group consisting of rs2278938, rs12641600, rs4862600, rs10002339, rs7694098, rs830829, rs830838, rs830841, rs2603731
The polymorphic site in the region containing MAST4 of human chromosome 5 is a single nucleotide polymorphism international number rs7733618, rs12514219, rs4532318, rs6861487, rs7700850, rs4587034, rs7705086, rs16895307, rs16895308, rs6890124, rs4339298, rs4613646, rs6862416, rs4532319, rs10515011 , Rs16895357, rs7732647, rs4355471, rs4554157, rs12055346, rs16895417, rs17210621, rs7706654, rs6864239, rs6896102, rs4374700, rs16895456, rs6880657, rs6863239, rs16895458, rs11953193, rs10940078, rs4446417, rs21 317 rs , Rs26384, rs7704890, rs7725568, rs30729, rs26383, rs27637, rs26382, rs9918275, rs258082, rs257699, rs257700, rs16895719, rs30731, rs16895744, rs1835136, rs36157, rs36155, rs544158, rs36144, rs36143, rs26923, rs219 , Rs192295, rs26929, rs26928, rs461702, rs460844, rs455938, rs464881, rs456775, rs154620, rs17217092, rs154618, rs10056426, rs15240 7. selected from the group consisting of rs2287929 and rs16896325, and NCBI (v36.1) 65944399,
Polymorphic sites in the region containing GLRX and / or C5orf27 of human chromosome 5 are single nucleotide polymorphism international numbers rs34896, rs34897, rs3777220, rs3777217, rs11738579, rs3777213, rs7736948, rs6556883, rs9314160, rs6876015, rs11135436, rs17085165, rs17085170 Rs10040697, rs6884979, rs7702848, rs2080947, rs10476660, rs154454, rs147295, rs17085249, rs11741590, rs3777194, rs2270554, rs3777190, rs3777188 and rs4642392, and NCBI (v36.1) 95206085,
The polymorphic site in the region containing EBF1 of human chromosome 5 is the single nucleotide polymorphism international number rs2913384, rs173423, rs244654, rs824854, rs824848, rs1095103, rs403334, rs10515769, rs2112262, rs33196, rs17056089, rs2042875, rs3843489, rs1541649, rs17056186 Rs2116727, rs10067813, rs7709065, rs17056205, rs1368298, rs4704963, rs10070743, rs4704967, rs10056564, rs6875710, rs17643057, rs6883655, rs891903, rs10054046, rs6556373, rs4921537, rs6556377, rs13180086, 655 , Rs9313797, rs1422672, rs17056474, rs17717829, rs10515787, rs10515786, rs10515789, rs9637861, rs7442845, rs12659540, rs3862065 and rs270661,
The polymorphic site in the region containing DOCK2 of human chromosome 5 is a single nucleotide polymorphism international number rs4493692, rs3797712, rs3797713, rs264881, rs36101422, rs264834, rs6879467, rs6883997, rs7721990, rs7713640, rs900464, rs264846, rs2161404, rs2306560, rs3816764 Rs11134586 rs12515906 rs264844 rs2279318 rs264843 rs10063658 rs4867879 rs17736846 rs264838 rs12658902 rs2306558 rs262865 rs262840 rs262841 rs262842 rs155239 rs262848 rs262851 rs4867572 rs46885213 , Rs10076580, rs6875474, rs185532, rs17669613, rs1013193, rs17669636, rs966595, rs17669654, rs13171272, rs261612, rs13163565, rs17737323, rs155074, rs261016, rs261597, rs166368, rs261633, rs2610054, rs261625, rs1753 , Rs17670092, rs7717087, rs17737597, rs7729471, rs261039, rs261038, rs1482333, rs2291229, rs261021, rs261076, rs12515095, rs17646 198, rs17560405, rs261067, rs261060, rs261006, rs261008, rs11740615, rs11741667, rs155023, rs11742527, rs978914, rs12522080, rs2624252, rs6896240, rs6862278, rs3860755, rs259897, rs259899, rs259900, rs259902, rs259903, rs259 rs17738158, rs17561105, rs11134600, rs6893165, rs2161366, rs9313476, rs17738326, rs2287727, rs17738444, rs6884677, rs13152920, rs9790867, rs11134603, rs17738530, rs2134151, rs12055169, rs17738584, rs10104629, 994 selected from the group consisting of rs17671355, rs6555884, rs17562083, rs10516070 and rs955078;
The polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 are single nucleotide polymorphism international numbers rs1044043, rs10484565, rs241438, rs1800454, rs241429, rs241427, rs4711312, rs2071482, rs4148882, rs12529313, rs9276815, rs20547, rs9276825, rs9276832, rs241404, rs241403, rs3101942, rs241400, rs3132132, rs151719, rs1050391, rs9378127, rs188245, rs3129305, rs176248, rs12216336, rs2894311, rs12191230, 1922391, 625 rs399604, rs365066, rs3763341, rs4713603, rs4713604, rs6936620, rs2116264, rs1367731, rs439852, rs446853, rs9296069, rs440841, rs3128952, rs3130180, rs3097662, rs3128955, rs3130588, rs9277183, rs3097669, rs9277, rs3097669, rs9277 rs2856816, rs3135021, rs1431403, rs9277542, rs3128963, rs3128965, rs3128966, rs3117229, rs2068204, rs2179920, rs2295120, rs3117242, rs3128921, rs3128923, rs9296079, rs31172 30, rs3128930, rs872956, rs9380343, rs6937034, rs6937061, rs9277637, rs3117039, rs3130233, rs3117016, rs2395351, rs3116985, rs3129249, rs3129248, rs1003979, rs2071025, rs2855459, rs439205, rs213679, rs461455, 31345814 rs211455, rs211453, rs10807124, rs411136, rs2772376, rs7747216, rs9469491, rs17627049, rs210137, rs9296095, rs210138, rs444697, rs1794681, rs9469529, rs4711332, rs12205634, rs1408711, rs1536041, rs2229637, rs1022738, rs2229637, rs102738 rs7759668, rs626156, rs498114, rs654682, rs16869412, rs10947432, rs3818532, rs9394163, rs12203688, rs4713670, rs4713671, rs622917, rs12189725, rs877187, rs4713674, rs4713677, rs943466, rs943467, rs755495, rs747475 selected from the group consisting of rs9366829, rs9394169, rs4713686 and rs10947441,
The polymorphic site in the region containing LOC100132919 of human chromosome 6 is the single nucleotide polymorphism international number rs1338657, rs9485685, rs9377361, rs9377365, rs9377366, rs9322660, rs9322661, rs2399802, rs17063309, rs680011, rs9499111, rs9404214, rs1569366, rs1569367, rs17443301 , Rs17063399, rs6906578 and rs7740643, and NCBI (v36.1) 102984444,
The polymorphic site in the region containing AAA1 and / or NPSR1 of human chromosome 7 is a single nucleotide polymorphism international number rs1156490, rs6462540, rs1419842, rs2392267, rs1419803, rs1419805, rs1419809, rs6977125, rs17169769, rs17169771, rs7778512, rs1419840, rs35114106 , Rs1019089, rs16878925, rs1362172, rs2392270, rs17831435, rs10951417, rs1468559, rs10486643, rs6951496, rs7458608, rs2893480, rs4723375, rs1419863, rs1419864, rs9639694, rs9639695, rs10951417, rs10215173 Rs16878959, rs12672624, rs10486649, rs2893482, rs12672538, rs10486650, rs2392274, rs2079509, rs10243426, rs2097960, rs1362173, rs1458549, rs450463, rs1023555, rs1023556, rs2530548, rs2530549, rs2530550, rs14565, rs2 , Rs323925, rs323912, rs10239860, rs1419791, rs17777040, rs17198254, rs17777663, rs17777675, rs17198982 Rs17788843, rs324978, rs324981, rs324983, rs1419780, rs325464, rs17199659, rs17789420, rs17789642, rs17170015, rs17200455, rs10263313, rs17790181 and rs11768189,
The polymorphic sites in the region containing ELMO1 of human chromosome 7 are single nucleotide polymorphism international numbers rs10277512, rs4720221, rs7787226, rs10951500, rs10274668, rs10255208, rs2006882, rs2392472, rs756507, rs2241152, rs7785934, rs7782979, rs17170754, rs3807162, rs3734948 Rs741302, rs2041801, rs6966276, rs4723592, rs11769038, rs4723598, rs1882080, rs4723601, rs11982286, rs1986619, rs1882082, rs10268319, rs17170799, rs6957979, rs10225164, rs2293628, rs999744, rs708, rs17170826, rs708 , Rs2541103, rs2541074, rs2541075, rs2551069, rs1420421, rs6958656, rs10257460, rs12666532, rs1420422, rs17170915, rs10224438, rs7809365, rs6963276, rs6967358, rs6967403, rs10279544, rs4723619, rs1717021, 694 , Rs2717975, rs10238916, rs2723952, rs12534004, rs2893540, rs2724006, rs2717983, rs2717990, rs27 01004, rs2724007, rs2717992, rs2723996, rs9655380, rs2701003, rs27110093, rs2724003, rs2723980, rs2723990, rs2717948, rs2700992, rs6462758, rs2724014, rs2724016, rs1882079, rs2717954, rs13247953, rs2392495, rs32031, rs2392495, rs10314634 rs2052688, rs2052687, rs10282309, rs10239693, rs17261508, rs10267165, rs918979, rs7777258, rs11767227, rs1647791, rs1732001, rs17171045, rs9655382 and rs6952260, and NCBI (v36.1) 3749522,
Polymorphic sites in the region containing TNKS of human chromosome 8 are single nucleotide polymorphism international numbers rs12680471, rs2085640, rs17149989, rs17730481, rs17663071, rs17663167, rs4841147, rs1458938, rs1458939, rs11786942, rs17674819, rs1466338, rs13253327, rs17150066, rs11777274 Rs11249921, rs17150087, rs1380104, rs11997346, rs4841156, rs6991328, rs17150131, rs7817148, rs10100760, rs17150181, rs17150185, rs17733293, rs7835349, rs7013746, rs7016636, rs3989158, rs17150211, rs4841698, rs4841174 , Rs6980831, rs12681719, rs4840427, rs4841179, rs7832096, rs4474027, rs4457339, rs12674762, rs4535743, rs1393, rs4342598, rs11780274, rs13273033, rs4841197, rs7010270, rs4841200, rs7459728, rs7461939, rs9124rs, 478 , Rs2898223, rs7820917, rs7829463, rs7000483, rs1567837, rs17734290, rs12540961, rs782973 3.
Polymorphic sites in the region containing ANGPT1 of human chromosome 8 are single nucleotide polymorphism international numbers rs12549261, rs10955436, rs6981257, rs11774921, rs11781710, rs1954724, rs6997025, rs1892764, rs16875775, rs11778352, rs2584372, rs2246255, rs2022958, rs2022949, rs168759 Rs1010824, rs2507799, rs10505100, rs11777978, rs16875983, rs9297393, rs7009229, rs13257393, rs4077322, rs11997995, rs10505105, rs4133396, rs4133395, rs4341141, rs10505107, rs11780324, rs35143736, rs17368715, rs17225 143 , Rs1283659, rs16876122, rs1632130, rs1672143, rs16876200, rs2514867, rs1283706, rs1283703, rs11785702, rs1283663, rs1283694, rs1433192, rs1433191, rs1298936, rs1368497, rs1529747, rs2916085, rs1368494, rs384776, rs1 , Rs1433172, rs10216767, rs1583300, rs281708, rs10955457, rs10103715, rs281673, rs43989 6, rs281685, rs281696, rs2014769, rs281740 and rs190735, and NCBI (v36.1) 108394240,
The polymorphic sites in the region containing PGM5 of human chromosome 9 are single nucleotide polymorphism international numbers rs3869296, rs7020465, rs11142449, rs11142461, rs10868851, rs13439981, rs7039076, rs265083, rs2131355, rs265087, rs265073, rs7861495, rs10869020, rs17085775, rs11795256 Rs10869034, rs1411992, rs10869043, rs12343877, rs11142941, rs869950, rs7046236 and rs9644996,
The polymorphic site in the region containing TMC1 of human chromosome 9 is a single nucleotide polymorphism international number rs3012514, rs7846808, rs7027640, rs10781101, rs4526421, rs7853275, rs10869178, rs7864535, rs12004208, rs6560277, rs4573342, rs4132905, rs4073227, rs10121866, rs7044241 , Rs7855743, rs4373587, rs11143314, rs7047875, rs6560284, rs6560285, rs7857300, rs6560287, rs7866185, rs6560293, rs7026124, rs12346185, rs7041300, rs4307407, rs17095, rs10113863, rs7029452, rs6560297, rs9324513 Rs2487471, rs2589623, rs2793153, rs2589615, rs969205, rs1796991, rs1838487, rs2589609, rs1663756, rs12351661, rs1663763, rs13298704 and rs2501914,
The polymorphic sites in the region containing ROR2 of human chromosome 9 are the single nucleotide polymorphism international numbers rs6479357, rs9409602, rs10991978, rs10991988, rs7867934, rs1388966, rs902923, rs902922, rs10512215, rs1532230, rs12337820, rs7029450, rs2131304, rs10992027, rs9299395 , Rs1388967, rs4073736, rs4073735, rs9409652, rs10992075, rs7031729, rs17585790, rs16907725, rs16907728, rs4372069, rs16907761, rs16907764, rs17586213, rs7039620, rs16907768, rs10992090, rs3802379, rs1195382, 474 , Rs10992124, rs7856144, rs7855417, rs6479374, rs1881385, rs16907863, rs12002851, rs1881392, rs10992137, rs7045226, rs11789730, rs16907923, rs12684524, rs7858435, rs10116326, rs16907979, rs10992161, rs6479386, 882 , Rs10820927, rs7867072, rs1954599 and rs10992207,
Polymorphic sites in the region containing PPP6C and / or C9orf126 of human chromosome 9 are single nucleotide polymorphism international numbers rs7022663, rs7024526, rs2289631, rs10986505, rs16927802, rs12001999, rs10819019, rs6478690, rs1017530, rs3824507, rs12352758, rs4838242, rs650599 , Rs7860360, rs2113352, rs7019234, rs7867749, rs2271746, rs16927930, rs10986618, rs10986626, rs12237026, rs463774, rs420423, rs10986641, rs10513445, rs393721, rs10819043, rs10986689, rs10986703, rs10986714, rs867146, rs10986714, rs109146 , Rs10986738, rs2819624 and rs3122938,
Polymorphic sites in the region containing GRID1 of human chromosome 10 are single nucleotide polymorphism international numbers rs2202925, rs17306253, rs10887498, rs12243608, rs1876887, rs2457451, rs2664403, rs2664394, rs1912274, rs1912322, rs744413, rs2664406, rs2664405, rs2616673, rs2175200 , Rs2175201, rs17105725, rs1912277, rs2457450, rs17105747, rs746992, rs7076174, rs4027581, rs11201743, rs4418740, rs17105793, rs12221324, rs17105805, rs7924009, rs11201759, rs11201775, rs3011700, rs2949380 , Rs2949384, rs2949385, rs2140666, rs2949386, rs1106789, rs11201804, rs17105912, rs17105916, rs2352181, rs947596, rs2352099, rs7924131, rs7923188, rs7923344, rs1418396, rs7899222, rs10788472, rs102001, rs10 , Rs7095652, rs12773130, rs12779841, rs10887544, rs11201871, rs10887549, rs10788476, rs2003111 rs7912451, rs11201882, rs2352178, rs7923926, rs7082134, rs4284352, rs6585995, rs6585996, rs5003944, rs7923310, rs884700, rs4934156, rs11201909, rs868042, rs12257526, rs12262754, rs11817682, rs12243396, rs1830156, rs1830156, rs1830156 rs2607822, rs10887563, rs10887564, rs2492738, rs1870161, rs2607839, rs1870165, rs2814340, rs1902678, rs2814349, rs1947567, rs2168725, rs1902680, rs2607833, rs1902676, rs1896527, rs65860010, rs65860010, rs65860010, rs6586004, rs6586004 rs12355013, rs7904985, rs10788500, rs10788501, rs10458771, rs2018507, rs10887608, rs4934207, rs4934208 and rs7083506,
The polymorphic site in the region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160) is a single nucleotide polymorphism international number rs7124648, rs7128650, rs4587689, rs11039097, rs12796744, rs17197619, rs17790390, rs11039105, rs10501319, rs11039112, rs747650, rs7937410, rs17197710, rs1685404, rs2013867, rs901746, rs7118396, rs10838681, rs10501321, rs1051006, rs3816712, rs7124955, rs37310 From rs11605672, rs1534576, rs10742805, rs12419692, rs4752856, rs3817334, rs7120548, rs10838739, rs11039329, rs10742817, rs4752791, rs17788930, rs7114011, rs10838774, rs2305982, rs6485788, rs10838782, rs7924699, rs18730, rs
The polymorphic site in the region containing OR5R1 of human chromosome 11 is the single nucleotide polymorphism international number rs1586004, rs7940239, rs10896302, rs17615246, rs10750820, rs1945245, rs3938998, rs10791979, rs1573511, rs12277883, rs7116573, rs44896287, rs1894026, rs1945 Rs1945211, rs7113069, rs11228306, rs12785840, rs10501353, rs1945203, rs585475, rs615231, rs617315, rs675991, rs7939886, rs4939052, rs621957, rs611534, rs594854, rs618594, rs634955 and rs613050,
The polymorphic site in the region containing MS4A7 and / or MS4A14 of human chromosome 11 is a single nucleotide polymorphism international number rs1026250, rs10750931, rs7126121, rs11230241, rs10897026, rs12225299, rs10792264, rs7125753, rs11605188, rs1899571, rs11230258, rs11230261, rs7943967 , Rs4442568, rs10897047, rs2868121, rs7945665, rs10897049, rs4506675, rs10792267, rs2304935, rs2165832, rs10736703, rs4939347, rs2233244, rs950803, rs950802, rs3816270, rs2241920, rs10501383, rs193963, rs193963, rs19 , Rs2120182, rs12787520, rs4146870, rs4939364, rs1051756, rs1941032, rs17615252, rs17543397, rs8181503, rs7946021, rs4939391, rs2186919, rs2847222, rs2633277 and rs2847212, and NCBI (v36.1) 59954904,
Polymorphic sites in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 are single nucleotide polymorphism international numbers rs565976, rs534179, rs2276443, rs532454, rs511190, rs566818, rs482458, rs1793412, rs1790149, rs1790155, rs1790154 , Rs668727, rs11600640, rs611449, rs11236449, rs661928, rs621305, rs11236452, rs7128888, rs7129014, rs688727, rs674503, rs606452, rs11236458, rs599816, rs660343, rs541993, rs601142, rs648930, rs611221, rs12574551, rs12574551, rs12574551, rs12574551, rs12574551 Rs10160335, rs12281880, rs656007, rs479592, rs589443, rs4944086, rs10751245, rs7110142, rs7947980 and rs509530, and NCBI (v36.1) 75005360,
The polymorphic site in the region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 is a single nucleotide polymorphism international number rs17120344, rs6589597, rs10790175, rs12420127, rs10892082, rs7107152, rs1242229, rs1784042, rs2269399, rs526602, rs664971, rs11216315, rs1263499, rs17120523, rs236919, rs528508, rs593245 and rs477036, and NCBI (v36.1) 116617736,
The polymorphic site in the region containing TAOK3 of human chromosome 12 is the single nucleotide polymorphism international number rs7297299, rs5745807, rs5745811, rs9739560, rs4767654, rs10638, rs9788041, rs11068799, rs11068803, rs10850953, rs7135008, rs11613924, rs7307331, rs9669474, rs7957463 , Rs10850956, rs2936840, rs904661, rs1726407, rs1726392, rs17440336, rs1277442, rs11068860, rs11068865, rs17512142, rs17440364, rs364823, rs418941, rs7974718, rs11068891, rs16948230, rs404566, rs16948234, rsrs124124rs, 7912 , Rs983421, rs1503767, rs7132650 and rs7316050,
Polymorphic sites in the region containing STX2 of human chromosome 12 are single nucleotide polymorphism international numbers rs7964173, rs11061064, rs10848174, rs7965385, rs7979388, rs7953972, rs4759749, rs4759751, rs7308461, rs1881062, rs10083153, rs729463, rs1881067, rs2695872, rs10848193 , Rs10848194, rs7305915, rs2398529, rs3864899, rs4412792, rs2632601, rs1554807, rs10848205, rs2037789, rs4619189, rs2001483, rs1609985, rs10848218, rs11061198, rs7307055, rs11061209, rs10773833, rs11061222, rs7299940 Selected from the group,
The polymorphic site in the region containing CARS2 of human chromosome 13 is the single nucleotide polymorphism international number rs9521809, rs4773201, rs1106649, rs9521814, rs385037, rs7997619, rs912941, s1886871, rs2182271, rs912942, rs331596, rs9559844, rs331602, rs1536621, rs9521853 , Rs9559849, rs7999854, rs3858821, rs4771696, rs4773228, rs4773229, rs2765341, rs3742193, rs3742194, rs7323602, rs3759463, rs179356, rs330565, rs7394, rs389656, rs450514, rs445490, rs418321, rs2251314, rs216541895, rs216541895 , As well as selected from the group consisting of NCBI (v36.1) 110097814,
The polymorphic site in the region containing CYP19A1 of human chromosome 15 is the single nucleotide polymorphism international number rs6493469, rs12595526, rs8031702, rs17599974, rs16953045, rs10744956, rs2306335, rs6493470, rs7181201, rs11856609, rs1124769, rs17647040, rs12899586, rs12904155, rs170 , Rs7177664, rs8040954, rs17647084, rs4775916, rs1111266, rs16964077, rs1025738, rs7179084, rs7176579, rs16964113, rs10519293, rs17522553, rs12324478, rs1075681, rs2899469, rs8031580, rs8029120, rs47745883, rs4458 , Rs700518, rs3759811, rs17703883, rs1865803, rs4775936, rs10459592, rs17523270, rs10519297, rs11636686, rs11636667, rs1062033, rs2008691, rs11636403, rs10519299, rs17647707, rs17647719, rs7167343, 495, rs125943, rs , Rs2445768, rs1551656, rs12441382, rs2446420, rs2124873, rs2470184, rs2470187, rs244 5781, rs12595284, rs17647970, rs7174434, rs7645430, rs7643830, rs12438104, rs16964308, rs4775942, rs16964316, rs2470172, rs2470173, rs16964319, rs10163098, rs12443092, rs2168623, rs3751586, rs2445741, rs8036694, rs2459396, and rs169643) Selected from the group,
The polymorphic site in the region containing CA10 of human chromosome 17 is the single nucleotide polymorphism international number rs4794268, rs4794274, rs4399573, rs12051837, rs6504736, rs7208167, rs9303589, rs1468118, rs10491154, rs17695254, rs2073864, rs9912472, rs3764798, rs17695921, rs11867674 , Rs886078, rs8076197, rs8076496, rs807396, rs2073866, rs9901183, rs4794293, rs8064617, rs4794294, rs985758, rs4794295, rs16950363, rs2873938, rs1263962, rs1263965, rs1263988, rs1263989, rs4794126, rs4791 , Rs1263984, rs9904076, rs4794304, rs8074185, rs6504747, rs16950512, rs7223782, rs4794305, rs16950534, rs1526182, rs1501255, rs4496207, rs1125750, rs1405187, rs767326, rs981577, rs4794307, 202, rs16950121, 202 , Rs203092, rs203093, rs203097, rs203098, rs10514990, rs203010, rs10514991, rs203022, rs6504754, rs12603762, rs169386, rs203042, rs7215008, rs996379, rs4794315, rs1501253, rs203050, rs203002, rs1005092, rs9896168, rs8065627, rs16950939, rs2907784, rs11079991, rs1393735, rs2970016, rs1875675, rs2938139, rs1354275, rs7221715, rs72217 rs2931368, rs2931365, rs2931364, rs9908649, rs1486745, rs4605214, rs1503041, rs10514997, rs10514998, rs11079993, rs1503050, rs1503051, rs10515000, rs12949235, rs1393734, rs17678475, rs16951169, rs12150128, rs16951105, rs16177 Selected from the group consisting of
The polymorphic site in the region containing LOC643542 of human chromosome 18 is a single nucleotide polymorphism international number rs8086948, rs12457951, rs11151371, rs17077389, rs1480679, rs5000099, rs1480682, rs433411, rs370944, rs395074, rs379982, rs281571, rs1444106, rs2448716, rs1562072 , Rs1867412, rs17077583, rs764133, rs17828615, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112, rs2448755, rs2448745, rs2440527, rs28379561, rs10503118, rs1562070, rs2448727, rs17077858, rs1293 Is selected from the group consisting of
The polymorphic sites in the region containing PTPRT of human chromosome 20 are single nucleotide polymorphism international numbers rs1884029, rs6072606, rs2207220, rs4812571, rs4572656, rs2013923, rs4812574, rs6513762, rs6513763, rs6029950, rs2144009, rs2866941, rs6102658, rs2144011, rs3787282 , Rs746413, rs4812578, rs6102671, rs1126101, rs6065434, rs4810352, rs1076666, rs6029980, rs6016688, rs2076249, rs17221018, rs17221067, rs17312515, rs17221137, rs6130047, rs16986551, rs17221326, rs16986558, rs126258rs, 70516 Rs2143008, rs6030030, rs2206169, rs6102713, rs6093598, rs6030070, rs6030071, rs1014757, rs2143632, rs6030076, rs16986712, rs727337, rs727336, rs6030096, rs11906485, rs2867026, rs16986733, rs11698118, rs6124439, rs169615745 , Rs4812588, rs6102795, rs11697499, rs4812591, rs916327, rs1883269, rs16986850, rs1033414, rs11700 137, rs6072747, rs999114, rs999113, rs6016798, rs2076082, rs6065482, rs6065484, rs6065487, rs6130145, rs230153, rs230154, rs172981, rs230155, rs6072758, rs230157, rs6124468, rs6102880, rs6130153, rs6065504, rs789 rs6030322, rs6072792, rs4482557, rs6130168, rs6030341, rs17747544, rs6065515, rs1883843, rs8119203, rs10854226, rs6102929, rs8121443, rs6030363, rs6102950, rs2867488, rs7360934, rs909863, rs6030370, rs6030380, 705 rs6030395, rs6065520, rs6072814, rs2206426, rs6016864, rs6072819, rs6030407, rs6065525, rs2425520, rs2425530, rs4812631, rs4810366, rs2017914, rs3092557, rs17749109, rs4812637, rs6030443, rs4 183, rs688 rs17749217, rs2146615, rs8119733, rs13042473, rs6103041, rs1973949, rs208256, rs208254, rs3092043, rs 2077768, rs208250, rs4812645, rs6130222, rs4812655, rs6130232, rs208230, rs208229, rs6065544, rs6065545, rs6065546, rs7262282, rs7262355, rs11699742, rs8125304, rs6065547, rs4812659, rs16987493, rs208272, rs208273, rs43636 rs4812664, rs4812665, rs16987668, rs206148, rs206154, rs206159, rs206163, rs2208048, rs2425546, rs2425553, rs2425554, rs2425560, rs2425562, rs1106978, rs6030634, rs6016951, rs1006746, rs2425587, rs927058, rs2425593, rs927058, rs24599 rs1572929, rs6072998, rs6030670, rs947202, rs947203, rs4812681, rs6093784, rs4812683, rs10485698, rs926288, rs1569445, rs6030689, rs2867656, rs11699547, rs6030709 and rs7267873, and NCBI (v36.1) 40130174,
The polymorphic site in the region containing ITSN1 of human chromosome 21 is a single nucleotide polymorphism international number rs12626309, rs2834231, rs4817579, rs2834238, rs2211689, rs2834246, rs2834251, rs2834252, rs1537097, rs1892589, rs2073368, rs2409499, rs9978415, rs2268247, rs9979937 , Rs2834264, rs2834268, rs879261, rs2245099, rs1108000, rs9979150, rs743316, rs2300384, rs3746861, rs2834292, rs2834295, rs2040113, rs2834296, rs2834297, rs2239565, rs17655810, rs12626410, rs28343013, rs2236645, 705 , Rs11088265, rs17730050 and rs2834332,
The polymorphic site in the region containing LRP2 of human chromosome 2 is a single nucleotide polymorphism international number rs13416802, rs2287616, rs2287613, rs3770597, rs10200158, rs6761690, rs13430236, rs3814381, rs4148765, rs10490134, rs11902639, rs10183805, rs13403114, rs3815574, rs2302698 , Rs6750251, rs4667590, rs4668121, rs1990702, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs11679947, rs10490132, rs2239602, rs2024481, rs741378, rs2284679, rs4287730, rs10210, rs10 Rs2268373, rs2268372, rs2193193, rs2268370, rs6747692, rs2300445, rs2239598, rs2239597, rs2239596, rs2239594, rs830957, rs830959, rs12988804, rs831002, rs16856748, rs11887007, rs16856759, rs830964, rs830971, rs8303 , Rs1990842, rs10199676, rs830955, rs12616998, rs12613663, rs10930354, rs4281872 and rs12052892 More is selected,
The polymorphic site in the region containing APIP and / or PDHX of human chromosome 11 is a single nucleotide polymorphism international number rs523246, rs10501136, rs836950, rs12808574, rs10836315, rs502857, rs731726, rs731727, rs967751, rs1553760, rs1396880, rs2941043, rs2941042 , Rs2941061, rs2956079, rs2941054, rs1509662, rs2941052, rs2915234, rs891550, rs919554, rs2915232, rs2956086, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs3751078, 694, rs220 , Rs2986429, rs2915217, rs7111607, rs2915214, rs984690, rs3763934, rs10488801, rs2956106, rs11032927, rs2915202, rs2915201, rs2915199, rs1998912, rs2915193, rs11032937, rs2915227, rs1082 263, rs8066703, rs8063 , Rs952489, rs514182, rs1425806, rs2732528, rs2553794, rs2553793, rs678137, rs2785156, rs2553787, rs737503, rs737502 rs2162159, rs2732552, rs387619, rs10836332, rs353610, rs353605, rs2785189, rs2553822, rs11032995, rs12291631, rs353590, rs353589, rs353587, rs1559759, rs4756190, rs353581, rs7106681, rs507230, rs634096, rs2732578, 7851 And
Polymorphic sites in the region containing CUX2 of human chromosome 12 are single nucleotide polymorphism international numbers rs7979656, rs10849918, rs2106407, rs2106406, rs12425190, rs11065783, rs2339706, rs4509829, rs7961663, rs4766526, rs4766442, rs4766443, rs12815195, rs12229654, rs756825 Rs16941284, rs6489979, rs4766553, rs9783423, rs7952972, rs16941319, rs3809290, rs7962233, rs4766451, rs886126, rs2078851, rs1265566, rs2301658, rs7300082, rs7300860, rs16941414, rs16939837, rs1693
The polymorphic site in the region containing TOM1L1 of human chromosome 17 is a single nucleotide polymorphism international number rs2332297, rs2934884, rs16955216, rs2934890, rs7225247, rs16955225, rs9303359, rs7207731, rs17683089, rs11658131, rs2958944, rs2934909, rs2934914, rs2934921, rs93358 Rs7221313, rs7210248, rs2958921, rs8079105, rs16955327, rs12949718, rs9899602, rs17745123, rs8070668, rs9910653, rs17817829, rs12936860, rs12951898, rs17817950 and rs2787501, and NCBI (v36.1) 50344775 (1) Inspection method.
（３）正常眼圧緑内障患者と健常者間での有意差をｐ値で表したとき、多型部位のｐ値が0.05未満を示す（１）又は（２）記載の検査方法。 (3) The examination method according to (1) or (2), wherein the p value of the polymorphic site is less than 0.05 when a significant difference between a normal-tension glaucoma patient and a healthy person is represented by a p value.
（４）ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs2562898、rs735860、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201l及びrs9367529からなる群より選択され、
　ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs2343466、rs11888802、rs2343468、rs12471726、rs2081297、rs10460504、rs6719211、rs3213787、rs4455206、rs3755076、rs3770264、rs10205197、rs17033745、rs17322370、rs17033801、rs748573、rs6708810、rs6710581、rs17033871、rs3755082、rs11884064及びrs556650からなる群より選択され、
　ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs12487524、rs872133、rs2197728、rs2359774、rs6799641、rs4678789、rs11129660、rs11129662、rs6779091、rs3772395、rs17228111、rs735353、rs11920715、rs1455489、rs4678509、rs10510667、rs6799649及びrs4234248からなる群より選択され、
　ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs11938753、rs7658065、rs17082122、rs4289492、rs9991256、rs7660334及びrs4604104からなる群より選択され、
　ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs2438083、rs7744559、rs9378292、rs2569866、rs11242704、rs2816286、rs2816287、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs1810496、rs12197419、rs2318108、rs6919059、rs17134506、rs3800142、rs3800146、rs10223785、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs9392353、rs11242730、rs4580917、rs11242733、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs11242740、rs3778557、rs234930、rs234915、rs234914、rs3800184、rs234932、rs3778568、rs9405550、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs7449538、rs6902556、rs6925653及びrs6904395からなる群より選択され、
　ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2077102、rs805301、rs2242655、rs707918、rs805292、rs2299851、rs707939、rs480092、rs2075800、rs2763979及びrs11965547からなる群より選択され、
　ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs6455585、rs6931414、rs6925091、rs6913912、rs894124、rs6455601及びrs3123094からなる群より選択され、
　ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs10246412、rs17404198、rs17149337、rs17404218、rs11976158、rs6978212、rs10261060、rs4401754、rs10278603、rs7787432、rs10237485及びNCBI(v36.1)8484291からなる群より選択され、
　ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs7794181、rs11763758、rs756669、rs4730038、rs4584085、rs17141284、rs17141299及びNCBI(v36.1)104196627からなる群より選択され、
　ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs1146192、rs1144219、rs2510356及びrs1866768からなる群より選択され、
　ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs514931、rs10871527及びrs17832851からなる群より選択され、
　ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs2298893、rs685300及びrs2056446からなる群より選択され、
　ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs6687571、rs2039528、rs10890251、rs10890257、rs12058744、rs11210879、rs10789438、rs11210892、rs617521及びrs10789439からなる群より選択され、
　ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200、rs12122453、rs12122534、rs517201、rs2031481、rs2477568、rs2477569、rs535827、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs17159914、rs6593745、rs6670503、rs6703187、rs10793652、rs7537483、rs7537703、rs3820130、rs3737845、rs4950315、rs10494244、rs6683839、rs10793656、rs17360443、rs12033407、rs10793661、rs10736837、rs10900336、rs4950409、rs10793682、rs11240055、rs17160256、rs17160264及びrs17160305からなる群より選択され、
　ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs11265310、rs16836320、rs868108、rs4845390、rs1984285、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822508、rs1749405、rs954916及びrs11590409からなる群より選択され、
　ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs227521、rs227519、rs10047146、rs10489307、rs1402640、rs10913291、rs10798503、rs725416、rs554454、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs17315298、rs2861972及びrs6672376からなる群より選択され、
　ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1404401、rs16847944、rs1572968、rs12143423、rs6427900及びrs2275860からなる群より選択され、
　ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs12613333、rs2723129、rs1465677、rs1864807、rs1864808、rs497973及びrs3806510からなる群より選択され、
　ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6808673、rs17194828、rs9310730、rs7652444、rs4858594、rs17787319、rs1505307、rs7640580、rs9833191、rs3951794及びrs5014281からなる群より選択され、
　ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs1993404、rs16863149、rs16863204、rs16863208、rs3732755、rs3773614、rs9820422、rs1388622及びrs4680474からなる群より選択され、
　ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10015164、rs10024359、rs11940307、rs2648120、rs2648117、rs4861686、rs4637445、rs2278938、rs12641600、rs4862600及びrs10002339からなる群より選択され、
　ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs16895719、rs16895744、rs37568、rs16896071、rs39664、rs469300、rs467845及びNCBI(v36.1)65944399からなる群より選択され、
　ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs6876015、rs11135436、rs6884979、rs7702848、rs2080947及びNCBI(v36.1)95206085からなる群より選択され、
　ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs1541649、rs2116727、rs10067813、rs7709065、rs10070743、rs10056564、rs6556373、rs4921537、rs1544754、rs17056426、rs1363561、rs1422672、rs10515787及びrs10515786からなる群より選択され、
　ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs7729471、rs261039、rs2291229、rs17646198、rs17560405、rs261006、rs155023、rs259900、rs13152920、rs11134603及びrs10462995からなる群より選択され、
　ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs10484565、rs9276825、rs188245、rs6457710、rs455567、rs211453、rs2772376、rs9469491、rs9296095、rs498114、rs654682、rs10947432、rs943466、rs755495、rs747692、rs943475、rs6929696、rs3828783及びrs9366829からなる群より選択され、
　ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs9377361、rs9322660、rs9322661、rs2399802、rs680011、rs9499111、rs1569366、rs1569367及びrs6906578からなる群より選択され、
　ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs12673387、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs10486649、rs12672538、rs450463、rs2530548、rs2530549、rs2530550、rs1458544、rs323925及びrs323912からなる群より選択され、
　ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs4720221、rs2392472、rs17170754、rs3807162及びrs11982286からなる群より選択され、
　ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs1466338、rs6991328、rs17150131、rs7817148、rs7016636、rs6985564、rs4840426、rs7832096、rs13273033、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs7820917、rs7829463、rs17734290、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996及びrs7828229からなる群より選択され、
　ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs16876200、rs2514867、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191及びrs10216767からなる群より選択され、
　ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs7020465、rs10868851、rs7039076、rs2131355、rs265073、rs7861495、rs10869020、rs11795256、rs10869034、rs1411992、rs10869043及びrs12343877からなる群より選択され、
　ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs7027640、rs12004208、rs6560277、rs7044241、rs4373587、rs11143314、rs7047875、rs7866185、rs7026124、rs12346185、rs7041300、rs4307407、rs10113863、rs7029452、rs7045535、rs13285932、rs10521449、rs1037031及びrs2487471からなる群より選択され、
　ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs10119449、rs7022147、rs7856144、rs6479374、rs1881385及びrs7045226からなる群より選択され、
　ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs1017530、rs7860360、rs2113352、rs7019234、rs2271746、rs10986618、rs10986626、rs10513445、rs10986703及びrs10986738からなる群より選択され、
　ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs11201743、rs17105793、rs17105805、rs11201775、rs10887549、rs10788476及びrs4284352からなる群より選択され、
　ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs11039112、rs747650、rs1685404、rs11570094、rs11039212、rs4992357、rs11605672、rs10742805、rs12419692、rs4752856、rs3817334、rs4752791、rs17788930、rs2305982、rs6485788、rs7924699及びrs1872167からなる群より選択され、
　ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs7113069、rs11228306、rs10501353、rs1945203、rs615231、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594及びrs634955からなる群より選択され、
　ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs4939347、rs2233244、rs3816270、rs2241920、rs10501383、s10897056及びrs4939352からなる群より選択され、
　ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs482458、rs661928、rs7128888、rs7129014、rs688727、rs12574551、rs17134231、rs12282340、rs10160335及びrs12281880からなる群より選択され、
　ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs664971、rs17120523及びrs528508からなる群より選択され、
　ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs10850953、rs1726392、rs17440336、rs17512142、rs17440364、rs16948230、rs16948234、rs17512483及びrs17512574からなる群より選択され、
　ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7305915、rs3864899、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483及びrs1405904からなる群より選択され、
　ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs4773201、rs450514、rs445490、rs418321及びrs2251314からなる群より選択され、
　ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs12595526、rs1124769、rs17647040、rs7170455、rs7177664、rs8040954、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs8023263、rs700518、rs3759811、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs11636403、rs10519299、rs2445765、rs12441382、rs2446420、rs2445781、rs7174434、rs12438104、rs4775942及びrs16964316からなる群より選択され、
　ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs12051837、rs6504736、rs4496207、rs9896969、rs203076、rs203090、rs203092、rs12603762、rs169386、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs1005092及びrs9896168からなる群より選択され、
　ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs433411、rs370944、rs395074、rs281571、rs2448716、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112及びrs17077963からなる群より選択され、
　ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs4572656、rs16986733、rs6016745、rs6016798、rs6065487、rs6130145、rs230153、rs230155、rs6072758、rs8119203、rs6030395、rs2425530、rs4812637、rs6030456、rs927058、rs2425593、rs16987770、rs6065579、rs6072998、rs6030670、rs947202、rs947203及びrs6093784からなる群より選択され、
　ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs2834268、rs9979150、rs2300384、rs3746861、rs2834292、rs2834303及びrs2236645からなる群より選択され、
　ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs4668121、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs2239602、rs741378、rs10210408、rs1548936、rs3770604、rs2075248、rs10169232、rs2239600、rs2284675、rs2268370、rs6747692、rs2239596、rs830957、rs830959、rs12988804、rs831002、rs1990842及びrs10199676からなる群より選択され、
　ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs836950、rs12808574、rs10836315、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs3763934、rs10488801、rs2956106、rs11032927、rs1998912、rs2915193、rs11032937、rs2915227、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs952489及びrs353589からなる群より選択され、
　ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs756825、rs4766553、rs3809290、rs4766451、rs886126、rs1265566、rs2301658及びrs7300082からなる群より選択され、
　ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs17817829、rs12951898、rs17817950及びNCBI(v36.1)50344775からなる群より選択される（３）記載の検査方法。 (4) The polymorphic site in the region containing ELOVL5 of human chromosome 6 is a single nucleotide polymorphism international number rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs2562898, rs735860, rs2057024, rs1570146, rs9463895, rs2235723, rs1346603, rs9474476, rs2294867, rs9349660, rs974323, rs6909592, rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517 and rs93775301l
The polymorphic sites in the region containing SRBD1 of human chromosome 2 are single nucleotide polymorphism international numbers rs2343466, rs11888802, rs2343468, rs12471726, rs2081297, rs10460504, rs6719211, rs3213787, rs4455206, rs3755076, rs3770264, rs10205197, rs17033745, rs17322370, rs17033801 Rs748573, rs6708810, rs6710581, rs17033871, rs3755082, rs11884064 and rs556650,
The polymorphic sites in the region containing ARPP-21 of human chromosome 3 are single nucleotide polymorphism international numbers rs12487524, rs872133, rs2197728, rs2359774, rs6799641, rs4678789, rs11129660, rs11129662, rs6779091, rs3772395, rs17228111, rs735353, rs11920715, rs1455489 , Rs4678509, rs10510667, rs6799649 and rs4234248,
Polymorphic sites in the region containing EPHA5 of human chromosome 4 are single nucleotide polymorphism international numbers rs371925, rs4241661, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs11938753, rs7658065, rs17082122, rs4289492, rs9991256, rs7660334 And rs4604104,
The polymorphic sites in the region containing GMDS of human chromosome 6 are single nucleotide polymorphism international numbers rs2438083, rs7744559, rs9378292, rs2569866, rs11242704, rs2816286, rs2816287, rs2317965, rs2873591, rs2569835, rs2745567, rs2493160, rs1810496, rs12197419, rs2318108 Rs6919059, rs17134506, rs3800142, rs3800146, rs10223785, rs6596866, rs4959621, rs4412249, rs4367413, rs11242729, rs6925298, rs9392353, rs11242730, rs4580917, rs11242733, rs11242735, rs476594, rs9378676, rs676015, rs264 Rs234914, rs3800184, rs234932, rs3778568, rs9405550, rs3823287, rs1196396, rs1684153, rs9328087, rs2479003, rs2479004, rs2505678, rs2479008, rs2505674, rs7766115, rs4959648, rs69049538, rs6902556, rs6925653 and rs69025653
Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 are represented by single nucleotide polymorphism international numbers rs2077102, rs805301, rs2242655, rs707918, rs805292, rs2299851, rs707939, rs480092, rs2075800, rs2763979 and rs11965547 Selected from the group consisting of
The polymorphic site in the region containing SYTL3 of human chromosome 6 is selected from the group consisting of single nucleotide polymorphism international numbers rs6455585, rs6931414, rs6925091, rs6913912, rs894124, rs6455601 and rs3123094;
The polymorphic sites in the region containing NXPH1 of human chromosome 7 are single nucleotide polymorphism international numbers rs10246412, rs17404198, rs17149337, rs17404218, rs11976158, rs6978212, rs10261060, rs4401754, rs10278603, rs7787432, rs10237485 and NCBI (v36.1) 8484291 Selected from the group consisting of
A polymorphic site in the region containing LHFPL3 of human chromosome 7 is selected from the group consisting of single nucleotide polymorphism international numbers rs7794181, rs11763758, rs756669, rs4730038, rs4584085, rs17141284, rs17141299 and NCBI (v36.1) 104196627;
A polymorphic site in the region containing GLB1L3 of human chromosome 11 is selected from the group consisting of single nucleotide polymorphism international numbers rs11223704, rs1146192, rs1144219, rs2510356 and rs1866768;
The polymorphic site in the region containing ZNF407 of human chromosome 18 is selected from the group consisting of single nucleotide polymorphism international numbers rs514931, rs10871527 and rs17832851,
The polymorphic site in the region containing PAX7 of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs2298893, rs685300 and rs2056446,
The polymorphic site in the region containing PTPRF of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs6687571, rs2039528, rs10890251, rs10890257, rs12058744, rs11210879, rs10789438, rs11210892, rs617521 and rs10789439,
The polymorphic site in the region including 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 is a single nucleotide polymorphism international number rs2355388, rs6686200, rs12122453, rs12122534, rs517201, rs2031481, rs2477568, rs2477569, rs535827, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs17159914, rs6593745, rs6670503, rs6703187, rs10793652, rs7537483, rs7537703, rs3820134, rs3153 selected from the group consisting of rs10793661, rs10736837, rs10900336, rs4950409, rs10793682, rs11240055, rs17160256, rs17160264 and rs17160305,
The polymorphic site in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1 is a single nucleotide polymorphism international number rs11265310, rs16836320, rs868108, rs4845390, rs1984285, rs11264339, rs3768566, rs11264345, rs7520184, rs12032720, rs11264359, rs11264363, rs5005770, rs1325908, rs11264375, rs475550, rs821551, rs822490, rs822508, rs1749405, rs954916 and rs11590409,
The polymorphic site in the region containing FAM5B and / or ASTN1 of human chromosome 1 is the single nucleotide polymorphism international number rs227521, rs227519, rs10047146, rs10489307, rs1402640, rs10913291, rs10798503, rs725416, rs554454, rs10913300, rs760689, rs6683060, rs926319 Rs6699955, rs10798508, rs2139876, rs17315298, rs2861972 and rs6672376,
The polymorphic site in the region containing PKP1 of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs1404401, rs16847944, rs1572968, rs12143423, rs6427900 and rs2275860,
The polymorphic site in the region containing KLHL29 and / or FLJ14126 of human chromosome 2 is selected from the group consisting of single nucleotide polymorphism international numbers rs12613333, rs2723129, rs1465677, rs1864807, rs1864808, rs497973 and rs3806510;
The polymorphic site in the region containing THRB of human chromosome 3 is selected from the group consisting of single nucleotide polymorphism international numbers rs1397878, rs6808673, rs17194828, rs9310730, rs7652444, rs4858594, rs17787319, rs1505307, rs7640580, rs9833191, rs3951794 and rs5014281 ,
The polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 is from the group consisting of single nucleotide polymorphism international numbers rs1993404, rs16863149, rs16863204, rs16863208, rs3732755, rs3773614, rs9820422, rs1388622 and rs4680474 Selected
The polymorphic site in the region containing SORBS2 of human chromosome 4 is selected from the group consisting of single nucleotide polymorphism international numbers rs10015164, rs10024359, rs11940307, rs2648120, rs2648117, rs4861686, rs4637445, rs2278938, rs12641600, rs4862600 and rs10002339,
A polymorphic site in the region containing MAST4 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs16895719, rs16895744, rs37568, rs16896071, rs39664, rs469300, rs467845 and NCBI (v36.1) 65944399;
The polymorphic site in the region containing GLRX and / or C5orf27 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs6876015, rs11135436, rs6884979, rs7702848, rs2080947 and NCBI (v36.1) 95206085,
The polymorphic site in the region containing EBF1 of human chromosome 5 consists of single nucleotide polymorphism international numbers rs1541649, rs2116727, rs10067813, rs7709065, rs10070743, rs10056564, rs6556373, rs4921537, rs1544754, rs17056426, rs1363561, rs1422672, rs10515787 and rs10515786 Selected from the group,
The polymorphic site in the region containing DOCK2 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs7729471, rs261039, rs2291229, rs17646198, rs17560405, rs261006, rs155023, rs259900, rs13152920, rs11134603 and rs10462995,
The polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 are single nucleotide polymorphism international numbers rs10484565, rs9276825, rs188245, rs6457710, rs455567, rs211453, rs2772376, rs9469491, selected from the group consisting of rs9296095, rs498114, rs654682, rs10947432, rs943466, rs755495, rs747692, rs943475, rs6929696, rs3828783 and rs9366829,
The polymorphic site in the region containing LOC100132919 of human chromosome 6 is selected from the group consisting of single nucleotide polymorphism international numbers rs9377361, rs9322660, rs9322661, rs2399802, rs680011, rs9499111, rs1569366, rs1569367 and rs6906578,
Polymorphic sites in the region containing AAA1 and / or NPSR1 of human chromosome 7 are single nucleotide polymorphism international numbers rs12673387, rs6950303, rs1034876, rs17169864, rs17169865, rs16878959, rs10486649, rs12672538, rs450463, rs2530548, rs2530549, rs2530550, rs1458544 , Rs323925 and rs323912,
The polymorphic site in the region containing ELMO1 of human chromosome 7 is selected from the group consisting of single nucleotide polymorphism international numbers rs4720221, rs2392472, rs17170754, rs3807162 and rs11982286;
The polymorphic sites in the region containing TNKS of human chromosome 8 are single nucleotide polymorphism international numbers rs1466338, rs6991328, rs17150131, rs7817148, rs7016636, rs6985564, rs4840426, rs7832096, rs13273033, rs4841200, rs7459728, rs7461939, rs9644708, rs12545912, rs4840437 Rs7004915, rs7820917, rs7829463, rs17734290, rs13270146, rs6601389, rs6601390, rs10098618, rs12056944, rs12543996 and rs7828229,
The polymorphic site in the region containing ANGPT1 of human chromosome 8 is selected from the group consisting of single nucleotide polymorphism international numbers rs16876200, rs2514867, rs11785702, rs1283663, rs1283694, rs1433192, rs1433191, and rs10216767,
The polymorphic site in the region containing PGM5 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs7020465, rs10868851, rs7039076, rs2131355, rs265073, rs7861495, rs10869020, rs11795256, rs10869034, rs1411992, rs10869043 and rs12343877 ,
The polymorphic site in the region containing TMC1 of human chromosome 9 is a single nucleotide polymorphism international number rs7027640, rs12004208, rs6560277, rs7044241, rs4373587, rs11143314, rs7047875, rs7866185, rs7026124, rs12346185, rs7041300, rs4307407, rs10113863, rs7029452, rs7045535 Selected from the group consisting of rs13285932, rs10521449, rs1037031 and rs2487471,
The polymorphic site in the region containing ROR2 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs10119449, rs7022147, rs7856144, rs6479374, rs1881385 and rs7045226,
The polymorphic site in the region containing PPP6C and / or C9orf126 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs1017530, rs7860360, rs2113352, rs7019234, rs2271746, rs10986618, rs10986626, rs10513445, rs10986703, and rs10986738 ,
The polymorphic site in the region containing GRID1 of human chromosome 10 is selected from the group consisting of single nucleotide polymorphism international numbers rs2202925, rs11201743, rs17105793, rs17105805, rs11201775, rs10887549, rs10788476 and rs4284352.
The polymorphic site in the region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160) is a single nucleotide polymorphism international number rs11039112, rs747650, rs1685404, rs11570094, rs11039212, rs4992357, rs11605672, rs10742805, rs12419692, rs4752856, rs3817334, rs4752791, rs17788930, rs2305982, rs6485788, rs7924699 and rs1872167,
The polymorphic site in the region containing OR5R1 of human chromosome 11 is the single nucleotide polymorphism international number rs1586004, rs7940239, rs10791979, rs1573511, rs12277883, rs7116573, rs10896333, rs4420287, rs18994026, rs7113069, rs11228306, rs10501353, rs1945203, rs615231, rs7939886 Selected from the group consisting of rs4939052, rs621957, rs611534, rs594854, rs618594 and rs634955,
The polymorphic site in the region containing human chromosome 11 MS4A7 and / or MS4A14 is selected from the group consisting of single nucleotide polymorphism international numbers rs4939347, rs2233244, rs3816270, rs2241920, rs10501383, s10897056 and rs4939352.
The polymorphic site in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 consists of the single nucleotide polymorphism international numbers rs482458, rs661928, rs7128888, rs7129014, rs688727, rs12574551, rs17134231, rs12282340, rs10160335 and rs12281880 Selected from the group,
The polymorphic site in the region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214) is selected from the group consisting of single nucleotide polymorphism international numbers rs664971, rs17120523 and rs528508
The polymorphic site in the region containing TAOK3 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs10850953, rs1726392, rs17440336, rs17512142, rs17440364, rs16948230, rs16948234, rs17512483 and rs17512574,
The polymorphic site in the region containing STX2 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs7305915, rs3864899, rs1554807, rs10848205, rs2037789, rs4619189, rs2001483 and rs1405904,
The polymorphic site in the region containing CARS2 of human chromosome 13 is selected from the group consisting of single nucleotide polymorphism international numbers rs4773201, rs450514, rs445490, rs418321 and rs2251314;
The polymorphic site in the region containing CYP19A1 of human chromosome 15 is a single nucleotide polymorphism international number rs12595526, rs1124769, rs17647040, rs7170455, rs7177664, rs8040954, rs8029120, rs4774583, rs2289105, rs8034835, rs6493489, rs8023263, rs700518, rs3759811, rs4775 , Rs10459592, rs17523270, rs10519297, rs11636686, rs11636667, rs11636403, rs10519299, rs2445765, rs12441382, rs2446420, rs2445781, rs7174434, rs12438104, rs4775942 and rs16964316,
Polymorphic sites in the region containing CA10 of human chromosome 17 are single nucleotide polymorphism international numbers rs4794268, rs4794274, rs12051837, rs6504736, rs4496207, rs9896969, rs203076, rs203090, rs203092, rs12603762, rs169386, rs7215008, rs996379, rs4794315, rs1501253 , Rs203050, rs1005092, and rs9896168,
The polymorphic site in the region containing LOC643542 of human chromosome 18 is selected from the group consisting of single nucleotide polymorphism international numbers rs433411, rs370944, rs395074, rs281571, rs2448716, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112 and rs17077963 ,
The polymorphic sites in the region containing PTPRT of human chromosome 20 are single nucleotide polymorphism international numbers rs4572656, rs16986733, rs6016745, rs6016798, rs6065487, rs6130145, rs230153, rs230155, rs6072758, rs8119203, rs6030395, rs2425530, rs4812637, rs6030456, rs927058 Rs2425593, rs16987770, rs6065579, rs6072998, rs6030670, rs947202, rs947203 and rs6093784,
A polymorphic site in the region containing ITSN1 of human chromosome 21 is selected from the group consisting of single nucleotide polymorphism international numbers rs2834268, rs9979150, rs2300384, rs3746861, rs2834292, rs2834303 and rs2236645;
The polymorphic site in the region containing LRP2 of human chromosome 2 is the single nucleotide polymorphism international number rs4668121, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs2239602, rs741378, rs10210408, rs1548936, rs3770604, rs2075248, rs10169232, rs2239600 Rs2284675, rs2268370, rs6747692, rs2239596, rs830957, rs830959, rs12988804, rs831002, rs1990842 and rs10199676,
The polymorphic site in the region containing APIP and / or PDHX of human chromosome 11 is a single nucleotide polymorphism international number rs836950, rs12808574, rs10836315, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs2985389, rs3751078, rs2915223, rs2915220 Rs2986427, rs1326940, rs1326941, rs1326942, rs2986429, rs2915217, rs7111607, rs2915214, rs3763934, rs10488801, rs2956106, rs11032927, rs1998912, rs2915193, rs11032937, rs2915227, rs2767038, rs3488353, rs2 Selected
The polymorphic site in the region containing CUX2 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs756825, rs4766553, rs3809290, rs4766451, rs886126, rs1265566, rs2301658 and rs7300082;
The testing method according to (3), wherein the polymorphic site in the region containing TOM1L1 of human chromosome 17 is selected from the group consisting of single nucleotide polymorphism international numbers rs17817829, rs12951898, rs17817950, and NCBI (v36.1) 50344775.
（５）正常眼圧緑内障の検査をするための試薬であって、下記の(a)及び(b)の成分からなる群より選択される少なくとも１つの成分を含む前記試薬。 (5) A reagent for examining normal-tension glaucoma, which comprises at least one component selected from the group consisting of the following components (a) and (b):
(a) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域を増幅することができるプライマー (a) 領域 Region of human chromosome 6 containing ELOVL5, region of human chromosome 2 containing SRBD1, region of human chromosome 3 containing ARPP-21, region of human chromosome 4 containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 and human chromosome 2 A region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6. 3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human chromosome 8 TNKS-containing region, human chromosome 8 ANGPT1 region, human chromosome 9 PGM5 region, human chromosome 9 TMC1 region, human chromosome 9 ROR2 region, human chromosome 9 A region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, A region containing chromosomal MS4A7 and / or MS4A14, a region containing human chromosome 11 MAP6 and / or GDPD5 and / or SERPINH1, a region containing human chromosome 11 11q23-24 (including PCSK7 and / or RNF214) A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, a region containing CA10 of human chromosome 17; A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11 Region containing, human Primers capable of amplifying a region containing at least one polymorphic sites in at least one area region and is selected from the group consisting of a region including a TOM1L1 human chromosome 17 containing CUX2 of 12 chromosomes
(b) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域にハイブリダイズすることができるプローブ
（６）（５）記載の試薬を含む、正常眼圧緑内障の検査キット。 (b) Human chromosome 6 region containing ELOVL5, human chromosome 2 region containing SRBD1, human chromosome 3 region containing ARPP-21, human chromosome 4 region containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 and A region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6. 3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human chromosome 8 TNKS-containing region, human chromosome 8 ANGPT1 region, human chromosome 9 PGM5 region, human chromosome 9 TMC1 region, human chromosome 9 ROR2 region, human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing area, human number A probe capable of hybridizing to a region containing at least one polymorphic site in at least one region selected from the group consisting of a region containing CUX2 of chromosome 2 and a region containing TOM1L1 of human chromosome 17 ( 6) A normal-tension glaucoma test kit comprising the reagent according to (5).
（７）ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む最長１０００塩基長の連続したＤＮＡ部分配列又はその相補鎖からなるポリヌクレオチドを含む正常眼圧緑内障診断用マーカー遺伝子。 (7) Region of human chromosome 6 containing ELOVL5, region of human chromosome 2 containing SRBD1, region of human chromosome 3 containing ARPP-21, region of human chromosome 4 containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 And / or FLJ14126 region, human chromosome 3 THRB region, human chromosome 3 MED12L and / or CLRN10S and / or GPR171 region, human chromosome 4 SORBS2 region, human chromosome 5 A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6 .3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human 8 Region containing TNKS of chromosome, region containing ANGPT1 of human chromosome 8, region containing PGM5 of human chromosome 9, region containing TMC1 of human chromosome 9, region containing ROR2 of human chromosome 9, human 9 Region containing PPP6C and / or C9orf126 of chromosome, G of human chromosome 10 A region containing RID1, a region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, Region containing MS4A7 and / or MS4A14 of chromosome 11, region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 , A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, and a region containing CA10 of human chromosome 17 A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, an APIP of human chromosome 11 and / or Region containing PDHX A continuous DNA portion having a maximum length of 1000 bases comprising at least one polymorphic site in at least one region selected from the group consisting of the region containing CUX2 of chromosome 12 and the region containing TOM1L1 of human chromosome 17. A marker gene for normal tension glaucoma diagnosis comprising a polynucleotide comprising a sequence or a complementary strand thereof.
（８）（７）記載のマーカー遺伝子のＤＮＡ配列を含有するベクター。 (8) A vector containing the DNA sequence of the marker gene according to (7).
（９）（８）記載のベクターで形質転換した宿主細胞。 (9) A host cell transformed with the vector according to (8).
（１０）（７）記載のマーカー遺伝子のＤＮＡ配列を含有するベクターで形質転換した宿主細胞を培養し、培養物から（７）記載のマーカー遺伝子のＤＮＡ配列がコードするポリペプチドを採取することを含む、ポリペプチドの製造方法。 (10) A host cell transformed with a vector containing the DNA sequence of the marker gene described in (7) is cultured, and a polypeptide encoded by the DNA sequence of the marker gene described in (7) is collected from the culture. A method for producing a polypeptide.
　本発明により、正常眼圧緑内障をより正確に診断することが可能となった。既に発症した患者では確定診断が可能となり、積極的な治療をおこなうことが可能となった。また、未発症者では発症の危険率が算出されるので、発症の危険率が高い未発症患者に対しては検査を頻回に行うことを勧め、早期発見につなげることができる。 The present invention makes it possible to more accurately diagnose normal-tension glaucoma. Patients who have already developed a definitive diagnosis, and can be actively treated. In addition, since the risk rate for the onset is calculated for those who have not yet developed, it is recommended that the test be performed frequently for undeveloped patients with a high risk rate for the onset, leading to early detection.
　本明細書は、本願の優先権の基礎である日本国特許出願、特願2008‐302986及び特願2009‐59937の明細書および／または図面に記載される内容を包含する。 This specification includes the contents described in the specification and / or drawings of Japanese Patent Application, Japanese Patent Application No. 2008-302986 and Japanese Patent Application No. 2009-59937, which are the basis of the priority of the present application.
第６染色体、ELOVL5を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸には0.5Mbにわたる当該領域内遺伝子の位置を示し、縦軸に有意差の指標であるp値を示す。下枠外にELOVL5遺伝子の位置を示す。当該領域でp=0.000023を最大とするSNPがELOVL5遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP in the area | region containing 6th chromosome and ELOVL5 and a healthy person is shown. The horizontal axis shows the position of the gene in the region over 0.5 Mb, and the vertical axis shows the p-value, which is a significant difference index. The position of ELOVL5 gene is shown outside the lower frame. In this region, SNP maximizing p = 0.000023 exists mainly in the ELOVL5 gene, indicating that the normal-tension glaucoma disease susceptibility gene exists in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region. 候補遺伝子を含む領域内における各SNPの患者と健常者間の有意差を示す。横軸にはMbで当該領域内遺伝子との位置関係を示し、縦軸に有意差の指標であるp値を示す。下枠外に遺伝子の位置と名前を示す。当該領域において患者と健常者間で有意な差を示すSNPが候補遺伝子を中心に存在し、この領域に正常眼圧緑内障疾患感受性遺伝子が存在することを示している。The significant difference between the patient of each SNP and the healthy subject in the area | region containing a candidate gene is shown. The horizontal axis indicates the positional relationship with the gene in the region in terms of Mb, and the vertical axis indicates the p value that is an index of significant difference. The position and name of the gene are shown outside the lower frame. SNPs showing a significant difference between patients and healthy subjects in this region are present mainly in candidate genes, indicating that normal pressure glaucoma disease susceptibility genes are present in this region.
　以下、本発明の実施の形態についてより詳細に説明する。 Hereinafter, embodiments of the present invention will be described in more detail.
　本発明者によって、正常眼圧緑内障に関連する遺伝子（正常眼圧緑内障疾患感受性遺伝子）が、ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域に存在することが解明された。正常眼圧緑内障の患者においては、有意に該遺伝子上に変異が見出されることから、該遺伝子上の変異の有無を調べることにより、被検者について正常眼圧緑内障であるか否かの検査、また、発症危険率の予測を行うことが可能である。 According to the present inventor, a gene related to normal-tension glaucoma (normal-tension glaucoma disease susceptibility gene) is a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, and an ARPP of human chromosome 3. -21 region, human chromosome 4 EPHA5 region, human chromosome 6 GMDS region, human chromosome 6p21.3 (including HSPA1B), human chromosome 6 SYTL3 A region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, a region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, and PAX7 of human chromosome 1. A region containing PTPRF of human chromosome 1, a region containing 1q12-q21.1 of human chromosome 1 (including CHD1L and / or FMO5), 1q21.2-q21.3 of human chromosome 1 (FDPS) And / or region containing ASH1L and / or KCNN3), human chromosome 1 A region containing FAM5B and / or ASTN1, a region containing PKP1 of human chromosome 1, a region containing KLHL29 and / or FLJ14126 of human chromosome 2, a region containing THRB of human chromosome 3, MED12L of human chromosome 3 And / or a region containing CLRN10S and / or GPR171, a region containing SORBS2 of human chromosome 4, a region containing MAST4 of human chromosome 5, a region containing GLRX and / or C5orf27 of human chromosome 5, human chromosome 5 A region containing EBF1 of human, a region containing DOCK2 of human chromosome 5, a region containing 6p21.31-p21.3 of human chromosome 6 (including HLA-DPA1), a region containing LOC100132919 of human chromosome 6, human A region containing AAA1 and / or NPSR1 of chromosome 7, a region containing ELMO1 of human chromosome 7, a region containing TNKS of human chromosome 8, a region containing ANGPT1 of human chromosome 8, and PGM5 of human chromosome 9 Region containing, region containing TMC1 of human chromosome 9, human ninth staining A region containing ROR2 of human chromosome 9, a region containing PPP6C and / or C9orf126 of human chromosome 9, a region containing GRID1 of human chromosome 10, 11p11.2 of human chromosome 11 (SPI1 and / or SLC39A13 and / or PSMC3 and / or PSMC3 and / or Or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, a region containing MS4A7 and / or MS4A14 of human chromosome 11, MAP6 and / or GDPD5 of human chromosome 11 and / or A region containing SERPINH1, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), a region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, human chromosome 13 A region containing CARS2 of human, a region containing CYP19A1 of human chromosome 15, a region containing CA10 of human chromosome 17, a region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, human chromosome 21 Territories including ITSN1 , A region containing LRP2 of human chromosome 2, a region containing APIP and / or PDHX of human chromosome 11, a region containing CUX2 of human chromosome 12, and a region containing TOM1L1 of human chromosome 17. It was elucidated. In patients with normal-tension glaucoma, since a mutation is found significantly on the gene, by examining the presence or absence of the mutation on the gene, a test for whether the subject has normal-tension glaucoma, It is also possible to predict the onset risk rate.
　本発明は、ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位の塩基を同定することを含む、正常眼圧緑内障の検査方法を提供する。 The present invention includes a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, a region containing ARPP-21 of human chromosome 3, a region containing EPHA5 of human chromosome 4, human chromosome 6 The region containing GMDS, the region containing 6p21.3 of human chromosome 6 (including HSPA1B), the region containing SYTL3 of human chromosome 6, the region containing NXPH1 of human chromosome 7, and the LHFPL3 of human chromosome 7 A region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, a region containing PAX7 of human chromosome 1, a region containing PTPRF of human chromosome 1, 1q12- of human chromosome 1 region containing q21.1 (including CHD1L and / or FMO5), region containing 1q21.2-q21.3 of human chromosome 1 (including FDPS and / or ASH1L and / or KCNN3), of human chromosome 1 Region containing FAM5B and / or ASTN1, region containing PKP1 of human chromosome 1, human chromosome 2 A region containing KLHL29 and / or FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, human fifth Chromosome MAST4 region, human chromosome 5 GLRX and / or C5orf27 region, human chromosome 5 EBF1 region, human chromosome 5 DOCK2 region, human chromosome 6p21.31- a region containing p21.3 (including HLA-DPA1), a region containing LOC100132919 of human chromosome 6, a region containing AAA1 and / or NPSR1 of human chromosome 7, a region containing ELMO1 of human chromosome 7, A region containing TNKS on chromosome 8, a region containing ANGPT1 on human chromosome 8, a region containing PGM5 on human chromosome 9, a region containing TMC1 on human chromosome 9, a region containing ROR2 on human chromosome 9, Region 9 containing PPP6C and / or C9orf126 of chromosome 9, human 10th stain A region containing GRID1 of the body, a region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11; A region containing MS4A7 and / or MS4A14 of human chromosome 11, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, and 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11. A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, and a CA10 of human chromosome 17 A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP of human chromosome 11 and Territory that includes PDHX Identifying the base of at least one polymorphic site in at least one region selected from the group consisting of a region comprising CUX2 of human chromosome 12 and a region comprising TOM1L1 of human chromosome 17. A method for examining normal-tension glaucoma is provided.
　本発明において、多型部位は、正常眼圧緑内障患者と健常者間で有意差を示すものであればよく、正常眼圧緑内障患者と健常者間の有意差の指標であるｐ値がより小さいものが望ましい。例えば、ｐ値が0.05未満なら、生物学的には明らかに有用であると通念上は判断される。ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域における多型部位とｐ値を後述の表１～５３に示す。上記の領域における多型部位で、正常眼圧緑内障患者と健常者間の有意差の指標であるｐ値が0.05未満のものは、これらの表から探すことができる。 In the present invention, the polymorphic site only needs to show a significant difference between a normal-tension glaucoma patient and a healthy person, and the p value that is an index of a significant difference between the normal-tension glaucoma patient and a healthy person is smaller. Things are desirable. For example, if the p-value is less than 0.05, it is customarily determined that it is clearly useful biologically. Includes the region containing ELOVL5 of human chromosome 6, the region containing SRBD1 of human chromosome 2, the region containing ARPP-21 of human chromosome 3, the region containing EPHA5 of human chromosome 4, and the GMDS of human chromosome 6. A region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, human Region containing GLB1L3 of chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21.1 of human chromosome 1 ( Region containing CHD1L and / or FMO5), region containing 1q21.2-q21.3 of human chromosome 1 (including FDPS and / or ASH1L and / or KCNN3), FAM5B of human chromosome 1 and / or A region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2, and / or Is a region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, MAST4 of human chromosome 5 A region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21.3 of human chromosome 6 (Including HLA-DPA1), a region containing LOC100132919 of human chromosome 6, a region containing AAA1 and / or NPSR1 of human chromosome 7, a region containing ELMO1 of human chromosome 7, A region containing TNKS, a region containing ANGPT1 of human chromosome 8, a region containing PGM5 of human chromosome 9, a region containing TMC1 of human chromosome 9, a region containing ROR2 of human chromosome 9, and the human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing region, human first Region including the CUX2 chromosomes, as well as the polymorphic site and the p value in the region including the TOM1L1 human chromosome 17 in Tables 1-53 below. The polymorphic sites in the above-mentioned region, and those having a p value of less than 0.05, which is an index of a significant difference between normal-tension glaucoma patients and healthy individuals, can be searched from these tables.
　ヒト第６染色体のELOVL5を含む領域における多型部位としては、一塩基多型国際番号rs222450、rs9474394、rs2816344、rs2816341、rs2518579、rs2518578、rs9367511、rs6915699、rs6930045、rs9370188、rs9382180、rs9382181、rs4486010、rs2816379、rs6939730、rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs10948744、rs12183976、rs2562898、rs735860、rs715441、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201、rs9367529、rs12209741、rs7744451、rs6904083、rs6904376、rs9367532、rs2067833、rs9382212、rs2139077、rs2397146、rs7742367、rs9474576、rs622447、rs3736729、rs13212365、rs761141などを例示することができるが、これらに限定されることはない。 The polymorphic site in the region containing ELOVL5 of human chromosome 6 includes single nucleotide polymorphism international numbers rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730, rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs1429146, rs9463895, rs2235723, 690 rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517, rs9370201, rs9367529, rs12209741, rs7744451, rs6904083, rs6904376, rs9367532, rs2067833, 973 774 Examples thereof include, but are not limited to, rs3736729, rs13212365, and rs761141.
　ヒト第２染色体のSRBD1を含む領域における多型部位としては、一塩基多型国際番号rs11686431、rs7580559、rs3908093、rs2343412、rs12623996、rs7573149、rs918810、rs6721199、rs7579209、rs10194925、rs17033378、rs2343466、rs17033398、rs6737172、rs4953226、rs3851333、rs12473388、rs11681887、rs35608719、rs11888802、rs11678872、rs2343468、rs13003019、rs6760244、rs12471726、rs2081297、rs10460504、rs7562458、rs4953230、rs4952763、rs6719211、rs1014454、rs3755070、rs3213787、rs10210691、rs3770251、rs4455206、rs3755076、rs3770254、rs11125017、rs3770264、rs10205197、rs10427308、rs17033745、rs3770278、rs17322370、rs6736954、rs10427402、rs4476395、rs13023749、rs17033801、rs755652、rs748573、rs6708810、rs6710581、rs12712945、rs17033871、rs3755082、rs6544840、rs7599740、rs11884064、rs7596942、rs7565326、rs17323037、rs1916231、rs1517001、rs1522988、rs614281、rs582213、rs650508、rs666334、rs17033965、rs556650、rs2204204、rs3795863、rs2285024、rs505310、rs10490342、rs612717、rs10490341、rs656823、rs563601、rs609573、rs6746467、rs637889、rs10495926、rs1522986、rs1522987、rs6544843、rs6724488などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing SRBD1 of human chromosome 2 include single nucleotide polymorphism international numbers rs11686431, rs7580559, rs3908093, rs2343412, rs12623996, rs7573149, rs918810, rs6721199, rs7579209, rs10194925, rs17033378, rs2343466, rs17033398, rs6737172, rs4953226, rs3851333, rs12473388, rs11681887, rs35608719, rs11888802, rs11678872, rs2343468, rs13003019, rs6760244, rs12471726, rs2081297, rs10460504, rs7562458, rs4953230, rs4952763, rs6719211, rs1014454, rs3755076, rs3755070 rs11125017, rs3770264, rs10205197, rs10427308, rs17033745, rs3770278, rs17322370, rs6736954, rs10427402, rs4476395, rs13023749, rs17033801, rs755652, rs748573, rs6708810, rs6710581, rs12712945, rs4 7354, 759 rs1916231, rs1517001, rs1522988, rs614281, rs582213, rs650508, rs666334, rs17033965, rs5 Examples include, but are not limited to, 56650, rs2204204, rs3795863, rs2285024, rs505310, rs10490342, rs612717, rs10490341, rs656823, rs563601, rs609573, rs6746467, rs637889, rs10495926, rs1522986, rs1522987, rs6544843, rs6724488, etc. There is no.
　ヒト第３染色体のARPP-21を含む領域における多型部位としては、一塩基多型国際番号rs1523048、rs1523029、rs12487524、rs1403468、rs872133、rs1523040、rs1523041、rs13069451、rs12629480、rs1357449、rs6801949、rs17033355、rs9873254、rs9839823、rs6794354、rs6794373、rs12637211、rs9855328、rs2037538、rs2037539、rs1523038、rs11718271、rs1608314、rs2197728、rs9311101、rs10490870、rs17033506、rs12634096、rs2359774、rs9860326、rs4678788、rs3213953、rs6799641、rs17201627、rs4678789、rs12632607、rs11129660、rs11129662、rs17033672、rs17280201、rs6779091、rs3772395、rs9872664、rs1963934、rs35102908、rs4678802、rs4678803、rs6550367、rs17033738、rs6801590、rs17033748、rs9865772、rs17033755、rs17228111、rs2016955、rs2016975、rs735353、rs11920715、rs1378481、rs17814981、rs1455489、rs4678509、rs10510667、rs6799649、rs6799609、rs17033836、rs4234248、rs6770245、rs10865865、rs7615307、rs9845811、rs17033961、rs1488092、rs10461001、rs17033999などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing ARPP-21 of human chromosome 3 include single nucleotide polymorphism international numbers rs1523048, rs1523029, rs12487524, rs1403468, rs872133, rs1523040, rs1523041, rs13069451, rs12629480, rs1357449, rs6801949, rs17033355, rs9873254, rs9839823, rs6794354, rs6794373, rs12637211, rs9855328, rs2037538, rs2037539, rs1523038, rs11718271, rs1608314, rs2197728, rs9311101, rs10490870, rs17033506, rs12634096, rs2359774, rs9860326, rs4678, rs32139126 rs17033672, rs17280201, rs6779091, rs3772395, rs9872664, rs1963934, rs35102908, rs4678802, rs4678803, rs6550367, rs17033738, rs6801590, rs17033748, rs9865772, rs17033755, rs17228111, rs2016955, rs119104, rs735353, rs11920714, rs735353, rs11920714 rs6799649, rs6799609, rs17033836, rs4234248, rs6770245, rs10865865, rs7615307, rs9845811, rs17033961 , Rs1488092, rs10461001, rs17033999, and the like, but is not limited thereto.
　ヒト第４染色体のEPHA5を含む領域における多型部位としては、一塩基多型国際番号rs371925、rs4241661、rs170654、rs1514271、rs2063419、rs13102419、rs11131589、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs4860651、rs11938753、rs1376417、rs10025570、rs1376416、rs2084682、rs7658065、rs9312144、rs1376412、rs17086181、rs17086185、rs6847413、rs2198103、rs12509018、rs17082122、rs6823779、rs17086224、rs1451170、rs4289492、rs4371663、rs9986026、rs9991256、rs4267782、rs7660334、rs6815080、rs11737314、rs4365778、rs7673091、rs4320185、rs4604104、rs7684022、rs4860679、rs6844942、rs12644315、rs4599467、rs6834811、rs4320186、rs4487412、rs7667410、rs4611975、rs4370201、rs4438803、rs4608860などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing EPHA5 of human chromosome 4 include single nucleotide polymorphism international numbers rs371925, rs4241661, rs170654, rs1514271, rs2063419, rs13102419, rs11131589, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs4860651, rs11938753, rs1376417, rs10025570, rs1376416, rs2084682, rs7658065, rs9312144, rs1376412, rs17086181, rs17086185, rs6847413, rs2198103, rs12509018, rs17082122, rs6823779, rs17086224, rs1451499, rs4289492, rs4289492 Examples can include rs11737314, rs4365778, rs7673091, rs4320185, rs4604104, rs7684022, rs4860679, rs6844942, rs12644315, rs4599467, rs6834811, rs4320186, rs4487412, rs7667410, rs4611975, rs4370201, rs4438803, rs4608860, etc. There is no.
　ヒト第６染色体のGMDSを含む領域における多型部位としては、一塩基多型国際番号rs11966212、rs2143396、rs6911992、rs9378593、rs9392253、rs9378594、rs2050158、rs9391900、rs6596786、rs2235706、rs9378596、rs1997773、rs6926322、rs7754106、rs7750178、rs742520、rs2210370、rs6940618、rs349100、rs9405444、rs6932005、rs4959523、rs10484953、rs464778、rs115705、rs1013185、rs11242672、rs463641、rs4959525、rs369656、rs459162、rs127091、rs4959530、rs463264、rs7757477、rs448915、rs444018、rs443971、rs9391913、rs238048、rs238050、rs9378605、rs2459602、rs2438074、rs12191625、rs2438077、rs2496292、rs2496301、rs2438083、rs977674、rs977673、rs17259747、rs1437288、rs7772349、rs6596805、rs1347656、rs6925983、rs1550199、rs11242676、rs7744559、rs11966550、rs9378290、rs9405136、rs9405470、rs9392285、rs9405137、rs9405471、rs746095、rs9378623、rs9378292、rs1711957、rs7742720、rs9378629、rs7741690、rs9328052、rs9328053、rs1922938、rs2745636、rs2816242、rs932410、rs1474721、rs9392296、rs9502950、rs6907725、rs9405484、rs4443540、rs4355648、rs9328058、rs9328059、rs2569866、rs6935712、rs6935896、rs6937266、rs6925228、rs11242704、rs2816286、rs2816287、rs6596833、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs2317966、rs9392305、rs9501738、rs2569839、rs9328061、rs9378300、rs2816221、rs6916316、rs2281272、rs2569824、rs9405496、rs1810496、rs2814827、rs7759035、rs9502997、rs2814811、rs2317964、rs9378304、rs2569854、rs12206340、rs4538755、rs9378305、rs9503011、rs9405505、rs9503015、rs9501762、rs9405506、rs12197419、rs7765344、rs7765461、rs1013303、rs3800046、rs689035、rs2318108、rs6919059、rs6928276、rs226456、rs9378314、rs1157673、rs1157675、rs9391933、rs9328071、rs3778533、rs1028714、rs3800094、rs3778539、rs6596857、rs7776397、rs6596858、rs9378661、rs3823279、rs3800122、rs10484693、rs17772389、rs4959160、rs3778555、rs4463305、rs3800140、rs17134506、rs3800142、rs3800143、rs3800144、rs3800146、rs2761234、rs9405156、rs17134549、rs1408002、rs1830733、rs1830734、rs10223785、rs9405157、rs7772545、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs12212324、rs9392353、rs11242730、rs4580917、rs6910252、rs11242733、rs9503080、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs17134693、rs3800156、rs11242740、rs4959635、rs3800159、rs3778557、rs3800168、rs4959642、rs234930、rs9392372、rs234915、rs234914、rs3800184、rs234932、rs6903476、rs3778568、rs9405550、rs17134819、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs4413658、rs7449538、rs9503158、rs6902556、rs6925653、rs4281006、rs12210286、rs12213061、rs4959663、rs9501836、rs6911665、rs13200914、rs17135028、rs4959184、rs11242770、rs9328099、rs12206851、rs6904395、rs17609498、rs742487、rs4959185、rs9391949、rs9391950、rs6899721、rs1610416、rs3924452、rs10458144、rs9501850、rs9503199、rs4959677、rs35374935、rs2449448、rs1772982、rs1680885、rs2794569、rs2624936、rs12196957、rs2624933、rs1773000、rs1773001、rs1614248、rs1616044、rs2624917、rs2624916、rs6899711などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing GMDS of human chromosome 6, the single nucleotide polymorphism international numbers rs11966212, rs2143396, rs6911992, rs9378593, rs9392253, rs9378594, rs2050158, rs9391900, rs6596786, rs2235706, rs9378596, rs6997322, rs6926322, rs7754106, rs7750178, rs742520, rs2210370, rs6940618, rs349100, rs9405444, rs6932005, rs4959523, rs10484953, rs464778, rs115705, rs1013185, rs11242672, rs463641, rs4959525, rs369656, rs459162, rs127091, rs4959530, 444 rs238048, rs238050, rs9378605, rs2459602, rs2496074, rs2438074, rs12191625, rs2438077, rs2496292, rs2496301, rs2438083, rs977674, rs977673, rs17259747, rs1437288, rs7772349, rs6596805, rs1347656, rs6925983, rs1550199, 540 rs9392285, rs9405137, rs9405471, rs746095, rs9378623, rs9378292, rs1711957, rs7742720, rs9378629, rs7741690, rs9328052 rs9328053, rs1922938, rs2745636, rs2816242, rs932410, rs1474721, rs9392296, rs9502950, rs6907725, rs9405484, rs4443540, rs4355648, rs9328058, rs9328059, rs2569866, rs6935712, rs6935896, rs693, rs704 rs2569835, rs2745567, rs2493160, rs2317966, rs9392305, rs9501738, rs2569839, rs9328061, rs9378300, rs2816221, rs6916316, rs2281272, rs2569824, rs9405496, rs1810496, rs2814827, rs7759035, rs9502997, rs2814812, rs64 rs9503011, rs9405505, rs9503015, rs9501762, rs9405506, rs12197419, rs7765344, rs7765461, rs1013303, rs3800046, rs689035, rs2318108, rs6919059, rs6928276, rs226456, rs9378314, rs1157673, rs93919310, rs5331 rs7776397, rs6596858, rs9378661, rs3823279, rs3800122, rs10484693, rs17772389, rs4959160, rs3778555, rs4463305, rs3800140, rs17134506, rs3800142, rs3800143, rs3800144, rs3800146, rs2761234, rs9405156, rs17134549, rs1408002, rs1830733, rs1830734, rs10223785, rs9405157, rs7772545, rs6596866, rs24959611, 441 rs11242730, rs4580917, rs6910252, rs11242733, rs9503080, rs11242735, rs476594, rs9378676, rs676015, rs2026446, rs4959631, rs17134693, rs3800156, rs11242740, rs4959635, rs3800159, rs3778557, rs3800168, rs4959642, rs234930, 914 rs6903476, rs3778568, rs9405550, rs17134819, rs3823287, rs1196396, rs1684153, rs9328087, rs2479003, rs2479004, rs2505678, rs2479008, rs2505674, rs7766115, rs4959648, rs4413658, rs9503122, rs69053122, rs69053122 rs6911665, rs13200914, rs17135028, rs4959184, rs11242770, rs9328099, rs12206851, rs690 4395, rs17609498, rs742487, rs4959185, rs9391949, rs9391950, rs6899721, rs1610416, rs3924452, rs10458144, rs9501850, rs9503199, rs4959677, rs35374935, rs2449448, rs1772982, rs1680885, rs2794569, rs2624936, rs262416, rs2624936 Although rs2624917, rs2624916, rs6899711, etc. can be illustrated, it is not limited to these.
　ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位としては、一塩基多型国際番号rs2248373、rs2248459、rs2248462、rs2248617、rs3749946、rs2523650、rs2904776、rs2516422、rs2905747、rs9267247、rs2395034、rs3095229、rs3131631、rs2516486、rs2734573、rs3115537、rs2516478、rs2071593、rs3219183、rs13215091、rs1799964、rs1052248、rs9348876、rs2857697、rs2736172、rs1046089、rs2255741、rs760293、rs2077102、rs3130048、rs2844463、rs805301、rs805300、rs805297、rs707921、rs2242655、rs707974、rs805268、rs805267、rs9378164、rs707918、rs805292、rs2299851、rs707939、rs707937、rs480092、rs2075800、rs2763979、rs11965547、rs486416、rs644045、rs537160、rs2072633、rs522162、rs550513、rs9296003、rs406936、rs492899などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 include single nucleotide polymorphism international numbers rs2248373, rs2248459, rs2248462, rs2248617, rs3749946, rs2523650, rs2904776, rs2516422, rs2905747, rs9267247, rs2395034 , Rs3095229, rs3131631, rs2516486, rs2734573, rs3115537, rs2516478, rs2071593, rs3219183, rs13215091, rs1799964, rs1052248, rs9348876, rs2857697, rs2736172, rs1046089, rs2255741, rs7603, rs844 Rs707974, rs805268, rs805267, rs9378164, rs707918, rs805292, rs2299851, rs707939, rs707937, rs480092, rs2075800, rs2763979, rs11965547, rs486416, rs6444045, rs537160, rs2072633, rs522162, rs550513, rs9296003, rs406936, rs492899 etc. However, it is not limited to these.
　ヒト第６染色体のSYTL3を含む領域における多型部位としては、一塩基多型国際番号rs602698、rs678116、rs649930、rs643677、rs592698、rs675053、rs612557、rs629364、rs627967、rs628203、rs2771425、rs9355655、rs10499309、rs1041566、rs12530454、rs7753885、rs9347236、rs6455585、rs6931414、rs10447366、rs9457403、rs9355246、rs4709219、rs4708797、rs4709226、rs4709235、rs6925091、rs3799195、rs6913912、rs894124、rs6903405、rs6901469、rs9364496、rs7759006、rs6455600、rs2129209、rs6455601、rs9456350、rs3123094、rs9456352、rs3102970、rs6455604、rs3127188、rs3127194、rs3127196、rs3102966、rs3127168、rs923198、rs6924755、rs2361472、rs4569991、rs9457516、rs9456363、rs9365009、rs3923902、rs12207795などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing SYTL3 of human chromosome 6 include single nucleotide polymorphism international numbers rs602698, rs678116, rs649930, rs643677, rs592698, rs675053, rs612557, rs629364, rs627967, rs628203, rs2771425, rs9355655, rs10499309, rs1041566, rs12530454, rs7753885, rs9347236, rs6455585, rs6931414, rs10447366, rs9457403, rs9355246, rs4709219, rs4708797, rs4709226, rs4709235, rs6925091, rs3799195, rs6913912, rs894124, rs6903405, rs9006, rs9364496, rs900 rs9456352, rs3102970, rs6455604, rs3127188, rs3127194, rs3127196, rs3102966, rs3127168, rs923198, rs6924755, rs2361472, rs4569991, rs9457516, rs9456363, rs9365009, rs3923902, rs12207795, etc. .
　ヒト第７染色体のNXPH1を含む領域における多型部位としては、一塩基多型国際番号rs3807826、rs7802863、rs3757521、rs3757520、rs3807823、rs1861032、rs17145870、rs7805508、rs6977682、rs3807815、rs1008038、rs3807811、rs11769978、rs3779356、rs3807807、rs3807806、rs7455929、rs6463790、rs4620183、rs12668479、rs17147407、rs11762595、rs12702719、rs17147608、rs12154895、rs17403198、rs16873367、rs42949、rs2349188、rs6463805、rs7811039、rs10247446、rs10270530、rs7795595、rs6945018、rs17148966、rs1476623、rs10246412、rs17404198、rs6463813、rs17149337、rs17404218、rs11976158、rs10244689、rs6978212、rs757704、rs2214694、rs2189904、rs765855、rs17150199、rs10261060、rs4401754、rs10266489、rs5018942、rs4556000、rs10278603、rs7787432、rs6959052、rs17150410、rs17150472、rs17150479、rs17150761、rs10237485、rs4720785、rs972247、rs1859274、rs10238726、rs6970999、rs17151821、rs7456267、rs6963180、rs10257265、rs970526、rs977458、rs13240427、rs17154007、並びにNCBI(v36.1)8484291などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing NXPH1 of human chromosome 7 include single nucleotide polymorphism international numbers rs3807826, rs7802863, rs3757521, rs3757520, rs3807823, rs1861032, rs17145870, rs7805508, rs6977682, rs3807815, rs1008038, rs3807811, rs11769978, rs3779356, rs3807807, rs3807806, rs7455929, rs6463790, rs4620183, rs12668479, rs17147407, rs11762595, rs12702719, rs17147608, rs12154895, rs17403198, rs16873367, rs42949, rs2349188, rs6463805, rs7811039, rs955, rs955, rs955 rs6463813, rs17149337, rs17404218, rs11976158, rs10244689, rs6978212, rs757704, rs2214694, rs2189904, rs765855, rs17150199, rs10261060, rs4401754, rs10266489, rs5018942, rs4556000, rs10278603, rs7787432, rs6959052, 1717147210, rs6959052, 1717147210 rs972247, rs1859274, rs10238726, rs6970999, rs17151821, rs7456267, rs6963180, rs10257265 , Rs970526, rs977458, rs13240427, rs17154007, NCBI (v36.1) 8484291, and the like, but are not limited thereto.
　ヒト第７染色体のLHFPL3を含む領域における多型部位としては、一塩基多型国際番号rs41521、rs2188486、rs977641、rs17389507、rs10274138、rs17136882、rs13234807、rs7794181、rs7787988、rs7787976、rs17331134、rs1557689、rs6465984、rs7798273、rs2188494、rs1468143、rs10953427、rs2214087、rs4730006、rs6952170、rs17137313、rs4727599、rs17137382、rs10228106、rs42181、rs4730010、rs11763758、rs17137711、rs11763095、rs6977743、rs4520098、rs10216261、rs11972050、rs12539136、rs756669、rs41037、rs41038、rs28253、rs41058、rs9649272、rs6949801、rs9987005、rs6465994、rs6465995、rs1477110、rs12216618、rs10254402、rs6969323、rs9641335、rs10272959、rs3919550、rs4730030、rs10246540、rs4730031、rs2891730、rs995661、rs10487221、rs10487222、rs11773248、rs11983223、rs6943307、rs7782065、rs7801387、rs12705261、rs12531723、rs17269890、rs4730038、rs4584085、rs10216010、rs17141284、rs17141299、rs10953450、rs6466018、rs4530975、rs12705276、rs4283980及びrs2470965、NCBI(v36.1) 103849313、104068646及び104196627などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing LHFPL3 of human chromosome 7 include single nucleotide polymorphism international numbers rs41521, rs2188486, rs977641, rs17389507, rs10274138, rs17136882, rs13234807, rs7794181, rs7787988, rs7787976, rs17331134, rs1557689, rs6465984, rs7798273, rs2188494, rs1468143, rs10953427, rs2214087, rs4730006, rs6952170, rs17137313, rs4727599, rs17137382, rs10228106, rs42181, rs4730010, rs11763758, rs17137711, rs11763095, rs6977743, rs4520098, rs10216261, rs11972050, rs123858 rs9649272, rs6949801, rs9987005, rs6465994, rs6465995, rs1477110, rs12216618, rs10254402, rs6969323, rs9641335, rs10272959, rs3919550, rs4730030, rs10246540, rs4730031, rs2891730, rs995661, rs10487221, rs10487222, rs11773 rs12531723, rs17269890, rs4730038, rs4584085, rs10216010, rs17141284, rs17141299, rs10953450, rs64660 18, rs4530975, rs12705276, rs4283980 and rs2470965, NCBI (v36.1) 103849313, 104068646, 104196627, and the like, but are not limited thereto.
　ヒト第１１染色体のGLB1L3を含む領域における多型部位としては、一塩基多型国際番号rs11223704、rs470713、rs470935、rs641024、rs11606866、rs7131644、rs10894784、rs1031381、rs522134、rs4362160、rs473041、rs498602、rs554874、rs1144225、rs1595895、rs1146192、rs4936229、rs1144219、rs2510356、rs553231、rs512359、rs568044、rs10894798、rs10894799、rs11223765、rs10894800、rs7940114、rs10894801、rs10791357、rs3741100、rs3741098、rs7113199、rs1866769、rs1866768、rs1561613などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing GLB1L3 of human chromosome 11 include single nucleotide polymorphism international numbers rs11223704, rs470713, rs470935, rs641024, rs11606866, rs7131644, rs10894784, rs1031381, rs522134, rs4362160, rs473041, rs498602, rs554874, rs1144225, rs1595895, rs1146192, rs4936229, rs1144219, rs2510356, rs553231, rs512359, rs568044, rs10894798, rs10894799, rs11223765, rs10894800, rs7940114, rs10894801, rs10791357, rs3741100, rs3741098, rs7113199, rs1866769, rs1866, etc. It is not limited to these.
　ヒト第１８染色体のZNF407を含む領域における多型部位としては、一塩基多型国際番号rs3794941、rs17055278、rs514931、rs494721、rs17055426、rs2896769、rs12717033、rs7227977、rs10871527、rs10514139、rs17832851、rs17055756、rs1473224、rs2628125、rs8085262、rs8089151、rs2628123、rs4891199、rs17055919、rs10514148、rs17055185、rs2404482、rs10514149、rs4337381、rs2959165、rs12456768、rs4891217、rs9945585、rs9961644、rs9961742、rs9952375、rs13381156、rs9319675、rs2120144、rs8096648、rs17056218、rs2289609、rs4891228、rs1396098、rs894575、rs10871567、rs7242893、rs7239800などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing ZNF407 of human chromosome 18 include single nucleotide polymorphism international numbers rs3794941, rs17055278, rs514931, rs494721, rs17055426, rs2896769, rs12717033, rs7227977, rs10871527, rs10514139, rs17832851, rs17055756, rs1473224, rs2628125, rs8085262, rs8089151, rs2628123, rs4891199, rs17055919, rs10514148, rs17055185, rs2404482, rs10514149, rs4337381, rs2959165, rs12456768, rs4891217, rs9945585, rs9961644, rs9961742, rs9952375, rs1338180, rs9319675, rs9319675 Examples include rs894575, rs10871567, rs7242893, and rs7239800, but are not limited thereto.
　ヒト第１染色体のPAX7を含む領域における多型部位としては、一塩基多型国際番号rs3000058、rs2816030、rs16862061、rs2816040、rs2816046、rs4920334、rs4920516、rs4920335、rs2816064、rs6704504、rs1934057、rs2298893、rs2743208、rs2076021、rs2076020、rs2236826、rs2282704、rs2282699、rs624761、rs851123、rs2236817、rs685300、rs2056446、rs2841078、rs4920344、rs6669544、rs4076925、rs6603910、rs11261070、rs7539659、rs11261074、rs7411058、rs4920545、rs6684577、rs12565195などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing PAX7 of human chromosome 1 include single nucleotide polymorphism international numbers rs3000058, rs2816030, rs16862061, rs2816040, rs2816046, rs4920334, rs4920516, rs4920335, rs2816064, rs6704504, rs1934057, rs2298893, rs2743208, rs2076021, rs2076020, rs2236826, rs2282704, rs2282699, rs624761, rs851123, rs2236817, rs685300, rs2056446, rs2841078, rs4920344, rs6669544, rs4076925, rs6603910, rs11261070, rs7539659, rs11261074, rs7411058, rs7720545, rs It is not limited to these.
　ヒト第１染色体のPTPRFを含む領域における多型部位としては、一塩基多型国際番号rs2494997、rs1999674、rs2842180、rs2255632、rs2251804、rs1334973、rs6687571、rs2039528、rs2819341、rs10890251、rs2367617、rs11210864、rs2782641、rs11210871、rs10890257、rs12058744、rs11210879、rs11210886、rs516790、rs641365、rs673485、rs643445、rs10789438、rs11210892、rs617521、rs660899、rs2274465、rs10789439、rs489319、rs607062、rs10789442及びrs3791035、NCBI(v36.1)43760103などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing PTPRF of human chromosome 1 include single nucleotide polymorphism international numbers rs2494997, rs1999674, rs2842180, rs2255632, rs2251804, rs1334973, rs6687571, rs2039528, rs2819341, rs10890251, rs2367617, rs11210864, rs2782641, rs11210871, rs10890257, rs12058744, rs11210879, rs11210886, rs516790, rs641365, rs673485, rs643445, rs10789438, rs11210892, rs617899, rs660899, rs2274465, rs10789439, rs489319, rs607062, rs10789442 and rs3791035 can be NCBI (v36.1) 43760 etc. However, it is not limited to these.
　ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位としては、一塩基多型国際番号rs2355388、rs6686200rs12122453、rs12122534、rs4950474、rs4950475、rs6593810、rs6657631、rs21327、rs517201、rs575115、rs2031481、rs2477568、rs2477569、rs692963、rs535827、rs4950361、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs2077749、rs17159914、rs6593745、rs2120003、rs10900325、rs2354432、rs6670503、rs1470261、rs6703187、rs10793652、rs7537483、rs7537703、rs1890038、rs3820130、rs3737845、rs17160062、rs3766525、rs4950315、rs17356240、rs10494244、rs6683839、rs10793656、rs17360443、rs3753433、rs12033407、rs7554833、rs10793661、rs10736837、rs10900336、rs7520661、rs4950409、rs2353983、rs6658836、rs17360812、rs6656156、rs12759145、rs12049491、rs10793682、rs4950431、rs7539416、rs2353969、rs4504949、rs17160205、rs2353967、rs12728058、rs6688308、rs11589438、rs6688154、rs6678706、rs4950436、rs7519891、rs11240053、rs11240054、rs11240055、rs7556087、rs7518276、rs2644579、rs2353951、rs2644577、rs6674761、rs2644566、rs2803535、rs17160256、rs12406844、rs17160264、rs612963、rs586000、rs17160295、rs644550、rs17160305などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 include single nucleotide polymorphism international numbers rs2355388, rs6686200rs12122453, rs12122534, rs4950474, rs4950475, rs6593810, rs6657631, rs21327 , Rs517201, rs575115, rs2031481, rs2477568, rs2477569, rs692963, rs535827, rs4950361, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs3, 745 , Rs6703187, rs10793652, rs7537483, rs7537703, rs1890038, rs3820130, rs3737845, rs17160062, rs3766525, rs4950315, rs17356240, rs10494244, rs6683839, rs10793656, rs17360443, rs3753433, rs12033407, rs7554833, rs1037374 , Rs17360812, rs6656156, rs12759145, rs12049491, rs10793682, rs4950431, rs7539416, rs2353969, rs4504949, rs17160205, rs2 353967, rs12728058, rs6688308, rs11589438, rs6688154, rs6678706, rs6950706, rs4950436, rs7519891, rs11240053, rs11240054, rs11240055, rs7556087, rs7518276, rs2644579, rs2353951, rs2644577, rs6674761, rs2644566, rs2803535, 1606174 Although rs644550, rs17160305, etc. can be illustrated, it is not limited to these.
　ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位としては、一塩基多型国際番号rs10752613、rs11583896、rs16835600、rs4434872、rs4567311、rs4363451、rs9427232、rs4845576、rs4520447、rs4845578、rs11585416、rs4845584、rs12033835、rs11581644、rs10908557、rs6701341、rs2297898、rs12048137、rs11264875、rs2066134、rs2494663、rs6671166、rs4845600、rs16835819、rs4521985、rs4620534、rs9803857、rs11265310、rs2340473、rs1194596、rs1212352、rs6672010、rs6702754、rs2274988、rs2297607、rs4414034、rs6696089、rs11265607、rs6427631、rs6427658、rs6694817、rs4537545、rs4845626、rs11265618、rs10752641、rs4240872、rs4474240、rs6700296、rs11265627、rs6691727、rs6687112、rs6427716、rs12136771、rs7553602、rs6660775、rs1127314、rs1127313、rs2131902、rs2229857、rs3766923、rs3766922、rs12125166、rs2335230、rs7531982、rs7533471、rs11264233、rs10796927、rs2335252、rs2036627、rs6699979、rs1995662、rs6664817、rs11264249、rs6426905、rs960182、rs16836320、rs868108、rs4845390、rs10494300、rs1051614、rs6666341、rs11808053、rs883319、rs1777910、rs951240ｖ、rs951241、rs9970364、rs1984285、rs6681725、rs16836414、rs10796934、rs10908445、rs4845678、rs4845679、rs4845681、rs12130132、rs10908448、rs4845690、rs4845406、rs10908455、rs7368345、rs10908456、rs4971079、rs4276913、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822519、rs822508、rs1749405、rs1749409、rs572609、rs3768280、rs2275078、rs2016251、rs1475766、rs12035615、rs4661146、rs6700693、rs10908489、rs11264449、rs2253677、rs2241110、rs2853641、rs2075163、rs2241107、rs1052053、rs1052067、rs759330、rs7542798、rs2253358、rs2842880、rs16837272、rs2287023、rs2246476、rs2248273、rs11264467、rs7522860、rs10908500、rs10494304、rs3795730、rs3762281、rs35478936、rs2274226、rs2985714、rs2842854、rs954916、rs6686886、rs11590409、rs4661040、rs7551781、rs16837376、rs11806983、rs1109751、rs11264486、rs3790458、rs1342442、rs12136856、rs10159180、rs1171564、rs1609666、rs728918、rs11264495、rs744224、rs4661184、rs879461、rs12742817、rs3795736、rs2236601、rs1046650、rs3795737などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1 include single nucleotide polymorphism international numbers rs10752613, rs11583896, rs16835600, rs4434872, rs4567311 , Rs4363451, rs9427232, rs4845576, rs4520447, rs4845578, rs11585416, rs4845584, rs12033835, rs11581644, rs10908557, rs6701341, rs2297898, rs12048137, rs11264875, rs2066134, rs2494663, rs6671166, rs4845600, rs19853 Rs1212352, rs6672010, rs6702754, rs2274988, rs2297607, rs4414034, rs6696089, rs11265607, rs6427631, rs6427658, rs6694817, rs4537545, rs4845626, rs11265618, rs10752641, rs4240872, rs4474240, rs6700296, rs1126564, rs11727 , Rs1127314, rs1127313, rs2131902, rs2229857, rs3766923, rs3766922, rs12125166, rs2335230, rs7531982, rs7533471, rs11264233, rs10796927 rs2335252, rs2036627, rs6699979, rs1995662, rs6664817, rs11264249, rs6426905, rs960182, rs16836320, rs868108, rs4845390, rs10494300, rs1051614, rs6666341, rs11808053, rs883319, rs1777910, rs951240v, rs951241, rs997034 rs4845678, rs4845679, rs4845681, rs12130132, rs10908448, rs4845690, rs4845406, rs10908455, rs7368345, rs10908456, rs4971079, rs4276913, rs11264339, rs3768566, rs11264345, rs7520184, rs12032720, rs1126413, rs5770 rs822519, rs822508, rs1749405, rs1749409, rs572609, rs3768280, rs2275078, rs2016251, rs1475766, rs12035615, rs4661146, rs6700693, rs10908489, rs11264449, rs2253677, rs2241110, rs2853641, rs20275163, rs2241107, 33010 rs16837272, rs2287023, rs2246476, rs2248273, rs11264467, rs7522860, rs10908500, rs10494304, rs3795730, rs3762281, rs35478936, rs2274226, rs2985714, rs2842854, rs954916, rs6686886, rs11590409, rs4661040, rs7551781, rs16837376, rs11806983, rs1109751, rs11264486, rs3790458, rs13411, rs1211 Examples thereof include, but are not limited to, rs4661184, rs879461, rs12742817, rs3795736, rs2236601, rs1046650, rs3795737, and the like.
　ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位としては、一塩基多型国際番号rs7521610、rs16850728、rs227521、rs227519、rs10047146、rs10489307、rs972484、rs1402640、rs10913291、rs12094495、rs10798503、rs6425414、rs7515582、rs10913294、rs7534953、rs10913295、rs725416、rs12090000、rs12564343、rs12031932、rs12079554、rs554454、rs6660903、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs16851037、rs17315298、rs2861972、rs1883243、rs6660559、rs4652245、rs4140633、rs7528533、rs3946142、rs6658794、rs9425456、rs6672376、rs12025407などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing FAM5B and / or ASTN1 of human chromosome 1, single nucleotide polymorphism international numbers rs7521610, rs16850728, rs227521, rs227519, rs10047146, rs10489307, rs972484, rs1402640, rs10913291, rs12094495, rs10798503, rs6425414, rs7515582, rs10913294, rs7534953, rs10913295, rs725416, rs12090000, rs12564343, rs12031932, rs12079554, rs554454, rs6660903, rs10913300, rs760689, rs6683060, rs926319, rs6699955, rs10798508, rs2139876, rs16851037, rs17315298 Examples thereof include, but are not limited to, rs7528533, rs3946142, rs6658794, rs9425456, rs6672376, rs12025407, and the like.
　ヒト第１染色体のPKP1を含む領域における多型部位としては、一塩基多型国際番号rs1122396、rs1722755、rs6413916、rs831771、rs1404401、rs831767、rs16847944、rs831765、rs16847947、rs831764、rs16847951、rs831762、rs831753、rs16847994、rs831751、rs4915220、rs10157719、rs947379、rs12466、rs1592085、rs4915499、rs12134467、rs10158798、rs1954214、rs12046907、rs10920161、rs12117501、rs1997018、rs1880450、rs1857489、rs16848184、rs868381、rs854488、rs832169、rs832174、rs700469、rs860554rs1779301、rs2300293、rs2268156、rs832147、rs854502、rs1722780、rs1779293、rs854505、rs1572968、rs17425876、rs12143423、rs947377、rs10753899、rs17459837、rs6427900、rs1122481、rs2275862、rs11806184、rs2365652、rs2275860、rs947485、rs6671391、rs1256941、rs10800779、rs7553988、rs10920205、rs3887566、rs3888929、rs6427908、rs12090950などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing PKP1 of human chromosome 1 include single nucleotide polymorphism international numbers rs1122396, rs1722755, rs6413916, rs831771, rs1404401, rs831767, rs16847944, rs831765, rs16847947, rs831764, rs16847951, rs831762, rs8317553, rs16847994, rs831751, rs4915220, rs10157719, rs947379, rs12466, rs1592085, rs4915499, rs12134467, rs10158798, rs1954214, rs12046907, rs10920161, rs12117501, rs1997018, rs1880450, rs1857489, rs16848184, rs868381, rs854488, rs832169, rs854488, rs832169 rs832147, rs854502, rs1722780, rs1779293, rs854505, rs1572968, rs17425876, rs12143423, rs947377, rs10753899, rs17459837, rs6427900, rs1122481, rs2275862, rs11806184, rs2365652, rs2275860, rs947485, rs6671395, rs947139 Although rs6427908, rs12090950, etc. can be illustrated, it is not limited to these.
　ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位としては、一塩基多型国際番号rs2577720、rs2723120、rs10495742、rs2577717、rs6720565、rs12053097、rs12613333、rs7566157、rs17045229、rs875077、rs17045238、rs2723129、rs2577698、rs2954818、rs12989910、rs11125011、rs6742888、rs7564616、rs2723111、rs6544822、rs893430、rs737564、rs737565、rs747344、rs6727901、rs7570872、rs17045350、rs6544861、rs6756357、rs4665214、rs10172684、rs1653748、rs1465677、rs1864807、rs1864808、rs4665218、rs10169643、rs1368080、rs10490750、rs11677730、rs7601971、rs1653751、rs1653753、rs1368081、rs11678782、rs11678785、rs4497835、rs1653780、rs17445645、rs4665223、rs4284788、rs4665612、rs1709339、rs6544949rs17045574、rs6544966、rs4665230、rs583168、rs17045705、rs2280122、rs1548020、rs518113、rs497973、rs3806510、rs13386930、rs6721623、rs3795933、rs7560892、rs4233701、rs9261、rs7579413、rs12470949、rs12478701、rs2081302、rs12478744、rs2339853、rs35379186などを例示することができるが、これらに限定されることはない。 As the polymorphic site in the region containing KLHL29 and / or FLJ14126 of human chromosome 2, the single nucleotide polymorphism international numbers rs2577720, rs2723120, rs10495742, rs2577717, rs6720565, rs12053097, rs12613333, rs7566157, rs17045229, rs875077, rs17045238, rs2723129, rs2577698, rs2954818, rs12989910, rs11125011, rs6742888, rs7564616, rs2723111, rs6544822, rs893430, rs737564, rs737565, rs747344, rs6727901, rs7570872, rs17045350, rs6544861, rs6756357, rs4665214, rs10172684, rs10172 rs1368080, rs10490750, rs11677730, rs7601971, rs1653751, rs1653753, rs1368081, rs11678782, rs11678785, rs4497835, rs1653780, rs17445645, rs4665223, rs4284788, rs4665612, rs1709339, rs6544949rs17045574, rs6544966, 7054, rs6544966, rs4 rs3806510, rs13386930, rs6721623, rs3795933, rs7560892, rs4233701, rs9261, rs7579413, rs1247094 9, rs12478701, rs2081302, rs12478744, rs2339853, rs35379186, and the like, but are not limited thereto.
　ヒト第３染色体のTHRBを含む領域における多型部位としては、一塩基多型国際番号rs1397878、rs6765461、rs6801153、rs1464010、rs7630879、rs6550848、rs826375、rs1667765、rs826378、rs6808673、rs2596623、rs17194828、rs1562736、rs9310730、rs2683535、rs7652337、rs7652444、rs2683542、rs1667739、rs1505302、rs6799431、rs17014338、rs826249、rs10510540、rs6772213、rs851719、rs6792783、rs1354605、rs866651、rs958892、rs826225、rs6550853、rs826223、rs826218、rs1466122、rs1449874、rs11719336、rs7625917、rs17787283、rs4858594、rs1449872、rs9849581、rs9863517、rs9843698、rs9867989、rs1667746、rs17787319、rs1505307、rs7640580、rs12639035、rs9810037、rs9833191、rs12630454、rs3951794、rs6781111、rs1505287、rs12495379、rs4858608、rs7624363、rs4640503、rs6550865、rs9839986、rs5014281、rs9831450、rs4241527、rs4858617、rs4858618、rs2196427、rs10490840、rs6788339、rs6765048、rs892941などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing THRB of human chromosome 3 include single nucleotide polymorphism international numbers rs1397878, rs6765461, rs6801153, rs1464010, rs7630879, rs6550848, rs826375, rs1667765, rs826378, rs6808673, rs2519423, rs17194828, rs1562736, rs9310730, rs2683535, rs7652337, rs7652444, rs2683542, rs1667739, rs1505302, rs6799431, rs17014338, rs826249, rs10510540, rs6772213, rs851719, rs6792783, rs1354605, rs866651, rs958892, rs826225, rs826223, rs8264, rs826223, rs82617 rs4858594, rs1449872, rs9849581, rs9863517, rs9843698, rs9867989, rs1667746, rs17787319, rs1505307, rs7640580, rs12639035, rs9810037, rs9833191, rs12630454, rs3951794, rs6781111, rs1505287, rs12495379, rs485814, 762 Illustrate rs4241527, rs4858617, rs4858618, rs2196427, rs10490840, rs6788339, rs6765048, rs892941, etc. However, it is not limited to these.
　ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位としては、一塩基多型国際番号rs13088412、rs9837084、rs744876、rs571170、rs358954、rs9833515、rs6440716、rs358967、rs1993404、rs9883677、rs2048229、rs16863149、rs891666、rs1835668、rs6787683、rs16863204、rs16863208、rs16863229、rs3732755、rs3773614、rs1231521、rs3108727、rs3773619、rs7649855、rs16863264、rs2870518、rs3846072、rs6782715、rs1882014、rs16863287、rs10513391、rs3773621、rs10935835、rs9863821、rs9864095、rs1873619、rs7623356、rs1491981、rs6440735、rs3971192、rs7644001、rs16863323、rs6801273、rs9820422、rs16863336、rs1388622、rs3975404、rs10513394、rs6787801、rs9289836、rs3821663、rs7429509、rs3821664、rs1491974、rs9653953、rs17204501、rs17204508、rs4680406、rs12490051、rs16863364、rs11708767、rs11709550、rs3732769、rs10935844、rs2276765、rs2276766、rs16863376、rs6440741、rs6771904、rs6772196、rs3732771、rs9864533、rs4435614、rs17204557、rs6798252、rs4680440、rs4680443、rs13088575、rs6790903、rs9289840、rs4680474、rs4541381、rs4596123及びrs7612205、NCBI(v36.1)152200518、152229595、152456055及び152609183などを例示することができるが、これらに限定されることはない。 Examples of the polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 include single nucleotide polymorphism international numbers rs13088412, rs9837084, rs744876, rs571170, rs358954, rs9833515, rs6440716, rs358967, rs1993404, rs9883677, rs2048229, rs16863149, rs891666, rs1835668, rs6787683, rs16863204, rs16863208, rs16863229, rs3732755, rs3773614, rs1231521, rs3108727, rs3773619, rs7649855, rs16863264, rs2870518, rs3846072, rs67813395, rs1882014, rs161 835 rs1873619, rs7623356, rs1491981, rs6440735, rs3971192, rs7644001, rs16863323, rs6801273, rs9820422, rs16863336, rs1388622, rs3975404, rs10513394, rs6787801, rs9289836, rs3821663, rs3821617, rs3953, rs395, rs3951 rs11708767, rs11709550, rs3732769, rs10935844, rs2276765, rs2276766, rs16863376, rs6440741, rs6771904, rs6772196, rs3732771, rs9864533, rs4435614, rs17204557, rs6798252, rs4680440, rs4680443, rs13088575, rs6790903, rs9289840, rs4680474, rs4541381, rs4596123 and rs7612205, NCBI (v36.1) 152200518, 152229595, 152456055 and 152 can be exemplified However, it is not limited to these.
　ヒト第４染色体のSORBS2を含む領域における多型部位としては、一塩基多型国際番号rs10866277、rs12645545、rs12649063、rs7437897、rs11132327、rs10866278、rs6823490、rs6843640、rs6818789、rs2101307、rs6552895、rs6552896、rs6552897、rs12498673、rs10025265、rs2306707、rs3749579、rs6848934、rs2306703、rs11934819、rs4862558、rs4599460、rs4862559、rs6823546、rs11132334、rs5018568、rs904451、rs7677363、rs2030144、rs11132338、rs11132340、rs7669883、rs6858544、rs1027521、rs2173480、rs2173479、rs11132344、rs10084919、rs7677532、rs6835720、rs10024805、rs6834923、rs6812818、rs10015164、rs11132345、rs10024359、rs10000785、rs1039235、rs2310357、rs10028428、rs4862571、rs7684943、rs10021308、rs1566347、rs12504307、rs11132355、rs10028944、rs1499010、rs11724690、rs11940307、rs1566354、rs2648126、rs2648120、rs2648117、rs2648112、rs4861686、rs1026362、rs12643549、rs2310372、rs4862588、rs10031442、rs4637445、rs1947455、rs2278938、rs12641600、rs4862600、rs10002339、rs7694098、rs830829、rs830838、rs830841、rs2603731rs7697039、rs7697051、rs1356672、rs7679967、rs4861696、rs1519320、rs12643213などを例示することができるが、これらに限定されることはない。 The polymorphic site in the region containing SORBS2 of human chromosome 4 includes single nucleotide polymorphism international numbers rs10866277, rs12645545, rs12649063, rs7437897, rs11132327, rs10866278, rs6823490, rs6843640, rs6818789, rs2512307, rs6552895, rs6552896, rs6552897, rs12498673, rs10025265, rs2306707, rs3749579, rs6848934, rs2306703, rs11934819, rs4862558, rs4599460, rs4862559, rs6823546, rs11132334, rs5018568, rs904451, rs7677363, rs2030144, rs11132338, rs7669883, rs6858544, rs10 rs6835720, rs10024805, rs6834923, rs6812818, rs10015164, rs11132345, rs10024359, rs10000785, rs1039235, rs2310357, rs10028428, rs4862571, rs7684943, rs10021308, rs1566347, rs12504307, rs11132355, rs24156, rs690 rs2648112, rs4861686, rs1026362, rs12643549, rs2310372, rs4862588, rs10031442, rs463744 5, rs1947455, rs2278938, rs12641600, rs4862600, rs10002339, rs7694098, rs830829, rs830838, rs830841, rs2603731rs7697039, rs7697051, rs1356672, rs7679967, rs4861696, rs1519320, rs12643213, etc. .
　ヒト第５染色体のMAST4を含む領域における多型部位としては、一塩基多型国際番号rs7733618、rs12514219、rs4532318、rs6861487、rs7700850、rs4587034、rs7705086、rs16895307、rs16895308、rs6890124、rs4339298、rs4613646、rs6862416、rs4532319、rs10515011、rs16895357、rs7732647、rs4355471、rs4554157、rs12055346、rs16895417、rs17210621、rs7706654、rs6864239、rs6896102、rs4374700、rs16895456、rs6880657、rs6863239、rs16895458、rs11953193、rs10940078、rs4446417、rs9791090、rs33721、rs33728、rs2548712、rs33696、rs257711、rs33724、rs26384、rs7704890、rs7725568、rs30729、rs26383、rs27637、rs26382、rs9918275、rs258082、rs257699、rs257700、rs16895719、rs30731、rs16895744、rs1835136、rs36157、rs36155、rs544158、rs36144、rs36143、rs26923、rs16895768、rs463219、rs16895790、rs26921、rs192295、rs26929、rs26928、rs461702、rs460844、rs455938、rs464881、rs456775、rs154620、rs17217092、rs154618、rs10056426、rs152407、rs37568、rs734828、rs2280174、rs16896071、rs40206、rs706701、rs17218390、rs6863305、rs39664、rs34691、rs34693、rs10044452、rs34698、rs34699、rs4016246、rs1159201、rs2662227、rs27206、rs469300、rs467845、rs2545396、rs16896246、rs16896295、rs17221226、rs2287929及びrs16896325、NCBI(v36.1)65944399などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region including MAST4 of human chromosome 5, single nucleotide polymorphism international numbers rs7733618, rs12514219, rs4532318, rs6861487, rs7700850, rs4587034, rs7705086, rs16895307, rs16895308, rs6890124, rs4339298, rs4613646, rs6862416, rs4532319, rs10515011, rs16895357, rs7732647, rs4355471, rs4554157, rs12055346, rs16895417, rs17210621, rs7706654, rs6864239, rs6896102, rs4374700, rs16895456, rs6880657, rs6863239, rs16895458, rs11953193, rs1094337, rs44490317, rs44490 rs33724, rs26384, rs7704890, rs7725568, rs30729, rs26383, rs27637, rs26382, rs9918275, rs258082, rs257699, rs257700, rs16895719, rs30731, rs16895744, rs1835136, rs36157, rs36155, rs544158, rs36144, rs36143, rs26995, 168 rs26921, rs192295, rs26929, rs26928, rs461702, rs460844, rs455938, rs464881, rs456775, rs154620, rs17217092, rs154618, rs100564 26, rs152407, rs37568, rs734828, rs2280174, rs16896071, rs40206, rs706701, rs17218390, rs6863305, rs39664, rs34691, rs34693, rs10044452, rs34698, rs34699, rs4016246, rs1159201, rs2662227, rs27206, rs469300, rs467845, 896, 246 Examples include rs17221226, rs2287929, and rs16896325, NCBI (v36.1) 65944399, but are not limited thereto.
　ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位としては、一塩基多型国際番号rs34896、rs34897、rs3777220、rs3777217、rs11738579、rs3777213、rs7736948、rs6556883、rs9314160、rs6876015、rs11135436、rs17085165、rs17085170、rs10040697、rs6884979、rs7702848、rs2080947、rs10476660、rs154454、rs147295、rs17085249、rs11741590、rs3777194、rs2270554、rs3777190、rs3777188及びrs4642392、NCBI(v36.1)95206085などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing GLRX and / or C5orf27 of human chromosome 5 include single nucleotide polymorphism international numbers rs34896, rs34897, rs3777220, rs3777217, rs11738579, rs3777213, rs7736948, rs6556883, rs9314160, rs6876015, rs11135436, rs17085165, rs17085170, rs10040697, rs6884979, rs7702848, rs2080947, rs10476660, rs154454, rs147295, rs17085249, rs11741590, rs3777194, rs2270554, rs3777190, rs3777188 and rs4642392, NCBI (v36.1) 95206085, etc. Never happen.
　ヒト第５染色体のEBF1を含む領域における多型部位としては、一塩基多型国際番号rs2913384、rs173423、rs244654、rs824854、rs824848、rs1095103、rs403334、rs10515769、rs2112262、rs33196、rs17056089、rs2042875、rs3843489、rs1541649、rs17056186、rs2116727、rs10067813、rs7709065、rs17056205、rs1368298、rs4704963、rs10070743、rs4704967、rs10056564、rs6875710、rs17643057、rs6883655、rs891903、rs10054046、rs6556373、rs4921537、rs6556377、rs13180086、rs6556379、rs6556381、rs1544754、rs883540、rs17056426、rs17056435、rs1363561、rs9313797、rs1422672、rs17056474、rs17717829、rs10515787、rs10515786、rs10515789、rs9637861、rs7442845、rs12659540、rs3862065、rs270661などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing EBF1 of human chromosome 5 include single nucleotide polymorphism international numbers rs2913384, rs173423, rs244654, rs824854, rs824848, rs1095103, rs403334, rs10515769, rs2112262, rs33196, rs17056089, rs2042875, rs3843489, rs1541649, rs17056186, rs2116727, rs10067813, rs7709065, rs17056205, rs1368298, rs4704963, rs10070743, rs4704967, rs10056564, rs6875710, rs17643057, rs6883655, rs891903, rs10054046, rs6556373, rs4921538, 655 Examples include, but are not limited to, rs1363561, rs9313797, rs1422672, rs17056474, rs17717829, rs10515787, rs10515786, rs10515789, rs9637861, rs7442845, rs12659540, rs3862065, rs270661, and the like.
　ヒト第５染色体のDOCK2を含む領域における多型部位としては、一塩基多型国際番号rs4493692、rs3797712、rs3797713、rs264881、rs36101422、rs264834、rs6879467、rs6883997、rs7721990、rs7713640、rs900464、rs264846、rs2161404、rs2306560、rs3816764、rs11134586、rs12515906、rs264844、rs2279318、rs264843、rs10063658、rs4867879、rs17736846、rs264838、rs12658902、rs2306558、rs262865、rs262840、rs262841、rs262842、rs155239、rs262848、rs262851、rs4867572、rs262852、rs746468、rs90213、rs17051884、rs262860、rs262859、rs10076580、rs6875474、rs185532、rs17669613、rs1013193、rs17669636、rs966595、rs17669654、rs13171272、rs261612、rs13163565、rs17737323、rs155074、rs261016、rs261597、rs166368、rs261633、rs10054135、rs261624、rs261625、rs17560224、rs4867895、rs168678、rs30080、rs30083、rs17670092、rs7717087、rs17737597、rs7729471、rs261039、rs261038、rs1482333、rs2291229、rs261021、rs261076、rs12515095、rs17646198、rs17560405、rs261067、rs261060、rs261006、rs261008、rs11740615、rs11741667、rs155023、rs11742527、rs978914、rs12522080、rs2624252、rs6896240、rs6862278、rs3860755、rs259897、rs259899、rs259900、rs259902、rs259903、rs6895199、rs259916、rs12659898、rs1422695、rs17738158、rs17561105、rs11134600、rs6893165、rs2161366、rs9313476、rs17738326、rs2287727、rs17738444、rs6884677、rs13152920、rs9790867、rs11134603、rs17738530、rs2134151、rs12055169、rs17738584、rs1316638、rs17072023、rs13361200、rs17738710、rs10462994、rs10462995、rs6890267、rs6871764、rs17671355、rs6555884、rs17562083、rs10516070、rs955078などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing DOCK2 of human chromosome 5, the single nucleotide polymorphism international numbers rs4493692, rs3797712, rs3797713, rs264881, rs36101422, rs264834, rs6879467, rs6883997, rs7721990, rs7713640, rs900464, rs264846, rs2161404, rs2306560, rs3816764, rs11134586, rs12515906, rs264844, rs2279318, rs264843, rs10063658, rs4867879, rs17736846, rs264838, rs12658902, rs2306558, rs262865, rs262840, rs262841, rs262842, rs155239, rs262848, rs262851, rs48675713, 262 rs262859, rs10076580, rs6875474, rs185532, rs17669613, rs1013193, rs17669636, rs966595, rs17669654, rs13171272, rs261612, rs13163565, rs17737323, rs155074, rs261016, rs261597, rs166368, rs261633, rsrs 175, 624, rs261 rs30083, rs17670092, rs7717087, rs17737597, rs7729471, rs261039, rs261038, rs1482333, rs2291229, rs261021, rs261076, rs125150 95, rs17646198, rs17560405, rs261067, rs261060, rs261006, rs261008, rs11740615, rs11741667, rs155023, rs11742527, rs978914, rs12522080, rs2624252, rs6896240, rs6862278, rs3860755, rs259897, rs259899, rs259900, rs259902,259 rs1422695, rs17738158, rs17561105, rs11134600, rs6893165, rs2161366, rs9313476, rs17738326, rs2287727, rs17738444, rs6884677, rs13152920, rs9790867, rs11134603, rs17738530, rs2134151, rs12055169, rs17738584, rs1316638, 170 Examples include rs6871764, rs17671355, rs6555884, rs17562083, rs10516070, and rs955078, but are not limited thereto.
　ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位としては、一塩基多型国際番号rs1044043、rs10484565、rs241438、rs1800454、rs241429、rs241427、rs4711312、rs2071482、rs4148882、rs12529313、rs9276815、rs20547、rs9276825、rs9276832、rs241404、rs241403、rs3101942、rs241400、rs3132132、rs151719、rs1050391、rs9378127、rs188245、rs3129305、rs176248、rs12216336、rs2894311、rs12191230、rs2395301、rs12192713、rs12199692、rs1044429、rs592625、rs399604、rs365066、rs3763341、rs4713603、rs4713604、rs6936620、rs2116264、rs1367731、rs439852、rs446853、rs9296069、rs440841、rs3128952、rs3130180、rs3097662、rs3128955、rs3130588、rs9277183、rs3097669、rs9277194、rs376877、rs6457710、rs3077、rs9348904、rs9296073、rs2856816、rs3135021、rs1431403、rs9277542、rs3128963、rs3128965、rs3128966、rs3117229、rs2068204、rs2179920、rs2295120、rs3117242、rs3128921、rs3128923、rs9296079、rs3117230、rs3128930、rs872956、rs9380343、rs6937034、rs6937061、rs9277637、rs3117039、rs3130233、rs3117016、rs2395351、rs3116985、rs3129249、rs3129248、rs1003979、rs2071025、rs2855459、rs439205、rs213208、rs461338、rs458679、rs455567、rs14398、rs3130267、rs3130014、rs211455、rs211453、rs10807124、rs411136、rs2772376、rs7747216、rs9469491、rs17627049、rs210137、rs9296095、rs210138、rs444697、rs1794681、rs9469529、rs4711332、rs12205634、rs1408711、rs1536041、rs2229637、rs10947427、rs3818527、rs3818528、rs3818530、rs4713659、rs594223、rs7759668、rs626156、rs498114、rs654682、rs16869412、rs10947432、rs3818532、rs9394163、rs12203688、rs4713670、rs4713671、rs622917、rs12189725、rs877187、rs4713674、rs4713677、rs943466、rs943467、rs755495、rs747692、rs943475、rs6929696、rs3806108、rs3828783、rs3763253、rs9366829、rs9394169、rs4713686、rs10947441などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 include single nucleotide polymorphism international numbers rs1044043, rs10484565, rs241438, rs1800454, rs241429, rs241427, rs4711312, rs2071482 , Rs4148882, rs12529313, rs9276815, rs92547, rs9276825, rs9276832, rs241404, rs241403, rs3101942, rs241400, rs3132132, rs151719, rs1050391, rs9378127, rs188245, rs3129305, rs176248, rs12216336, rs2894311, rs12191230, 1922391, , Rs399604, rs365066, rs3763341, rs4713603, rs4713604, rs6936620, rs2116264, rs1367731, rs439852, rs446853, rs9296069, rs440841, rs3128952, rs3130180, rs3097662, rs3128955, rs3130588, rs9277183, rs3097774, rs779777, rs779777 , Rs2856816, rs3135021, rs1431403, rs9277542, rs3128963, rs3128965, rs3128966, rs3117229, rs2068204, rs2179920, rs2295120, rs3117242, rs3128921, rs3128923, rs92960 79, rs3117230, rs3128930, rs872956, rs9380343, rs6937034, rs6937061, rs9277637, rs3117039, rs3130233, rs3117016, rs2395351, rs3116985, rs3129249, rs3129248, rs1003979, rs2071025, rs2855459, rs439205, rs2132083, rs338205 rs3130014, rs211455, rs211453, rs10807124, rs411136, rs2772376, rs7747216, rs9469491, rs17627049, rs210137, rs9296095, rs210138, rs444697, rs1794681, rs9469529, rs4711332, rs12205634, rs1408711, rs15360410, rs1534 427 rs594223, rs7759668, rs626156, rs498114, rs654682, rs16869412, rs10947432, rs3818532, rs9394163, rs12203688, rs4713670, rs4713671, rs622917, rs12189725, rs877187, rs4713674, rs4713677, rs943466, rs943467, rs755495, 694 Examples include, but are not limited to, rs3763253, rs9366829, rs9394169, rs4713686, rs10947441, etc. It will never be.
　ヒト第６染色体のLOC100132919を含む領域における多型部位としては、一塩基多型国際番号rs1338657、rs9485685、rs9377361、rs9377365、rs9377366、rs9322660、rs9322661、rs2399802、rs17063309、rs680011、rs9499111、rs9404214、rs1569366、rs1569367、rs17443301、rs17063399、rs6906578及びrs7740643、NCBI(v36.1)102984444などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region including LOC100132919 of human chromosome 6 include single nucleotide polymorphism international numbers rs1338657, rs9485685, rs9377361, rs9377365, rs9377366, rs9322660, rs9322661, rs2399802, rs17063309, rs680011, rs9499111, rs9404214, rs1569366, rs1569367, Examples thereof include, but are not limited to, rs17443301, rs17063399, rs6906578 and rs7740643, NCBI (v36.1) 102984444, and the like.
　ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位としては、一塩基多型国際番号rs1156490、rs6462540、rs1419842、rs2392267、rs1419803、rs1419805、rs1419809、rs6977125、rs17169769、rs17169771、rs7778512、rs1419840、rs35114106、rs1019089、rs16878925、rs1362172、rs2392270、rs17831435、rs10951417、rs1468559、rs10486643、rs6951496、rs7458608、rs2893480、rs4723375、rs1419863、rs1419864、rs9639694、rs9639695、rs10951418、rs10215667、rs6971556、rs12673387、rs4723377、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs12672624、rs10486649、rs2893482、rs12672538、rs10486650、rs2392274、rs2079509、rs10243426、rs2097960、rs1362173、rs1458549、rs450463、rs1023555、rs1023556、rs2530548、rs2530549、rs2530550、rs1419794、rs2530565、rs1458544、rs2609226、rs9792042、rs2530567、rs2609218、rs323925、rs323912、rs10239860、rs1419791、rs17777040、rs17198254、rs17777663、rs17777675、rs17198982、rs17788843、rs324978、rs324981、rs324983、rs1419780、rs325464、rs17199659、rs17789420、rs17789642、rs17170015、rs17200455、rs10263313、rs17790181、rs11768189などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing AAA1 and / or NPSR1 of human chromosome 7 include the single nucleotide polymorphism international numbers rs1156490, rs6462540, rs1419842, rs2392267, rs1419803, rs1419805, rs1419809, rs6977125, rs17169769, rs17169771, rs7778512, rs1419840, rs35114106, rs1019089, rs16878925, rs1362172, rs2392270, rs17831435, rs10951417, rs1468559, rs10486643, rs6951496, rs7458608, rs2893480, rs4723375, rs1419863, rs1419864, rs9639694, rs9639695, 1737, rs10215667, 971 rs17169865, rs16878959, rs12672624, rs10486649, rs2893482, rs12672538, rs10486650, rs2392274, rs2079509, rs10243426, rs2097960, rs1362173, rs1458549, rs450463, rs1023555, rs1023556, rs2530548, rs2530549, rs4530550, rs4530550, rs4530550, rs4530550 rs2609218, rs323925, rs323912, rs10239860, rs1419791, rs17777040, rs17198254, rs17777663, rs17777675 rs17198982, rs17788843, rs324978, rs324981, rs324983, rs1419780, rs325464, rs17199659, rs17789420, rs17789642, rs17170015, rs17200455, rs10263313, rs17790181, can be exemplified such Rs11768189, is not limited thereto.
　ヒト第７染色体のELMO1を含む領域における多型部位としては、一塩基多型国際番号rs10277512、rs4720221、rs7787226、rs10951500、rs10274668、rs10255208、rs2006882、rs2392472、rs756507、rs2241152、rs7785934、rs7782979、rs17170754、rs3807162、rs3734948、rs741302、rs2041801、rs6966276、rs4723592、rs11769038、rs4723598、rs1882080、rs4723601、rs11982286、rs1986619、rs1882082、rs10268319、rs17170799、rs6957979、rs10225164、rs2293628、rs999744、rs17170820、rs17170826、rs17170830、rs1364373、rs13233995、rs6971267、rs7809487、rs1035582、rs2541103、rs2541074、rs2541075、rs2551069、rs1420421、rs6958656、rs10257460、rs12666532、rs1420422、rs17170915、rs10224438、rs7809365、rs6963276、rs6967358、rs6967403、rs10279544、rs4723619、rs17170955、rs2723969、rs6944921、rs6462746、rs1016321、rs2541082、rs4723631、rs2541089、rs2717975、rs10238916、rs2723952、rs12534004、rs2893540、rs2724006、rs2717983、rs2717990、rs2701004、rs2724007、rs2717992、rs2723996、rs9655380、rs2701003、rs2717993、rs2724003、rs2723980、rs2723990、rs2717948、rs2700992、rs6462758、rs2724014、rs2724016、rs1882079、rs2717954、rs13247953、rs2392495、rs10233634、rs12532031、rs4720246、rs7782999、rs1425124、rs1647801、rs2052688、rs2052687、rs10282309、rs10239693、rs17261508、rs10267165、rs918979、rs7777258、rs11767227、rs1647791、rs1732001、rs17171045、rs9655382及びrs6952260、NCBI(v36.1)37495022などを例示することができるが、これらに限定されることはない。 The polymorphic sites in the region containing ELMO1 of human chromosome 7 include single nucleotide polymorphism international numbers rs10277512, rs4720221, rs7787226, rs10951500, rs10274668, rs10255208, rs2006882, rs2392472, rs756507, rs2241152, rs7785934, rs7782979, rs17170754, rs3807162, rs3734948, rs741302, rs2041801, rs2049661, rs669276, rs4723592, rs11769038, rs4723598, rs1882080, rs4723601, rs11982286, rs1986619, rs1882082, rs10268319, rs17170799, rs6957979, rs10225164, rs999744, rs17170820, rs170826, rs17170820, rs170826 rs1035582, rs2541103, rs2541074, rs2541075, rs2551069, rs1420421, rs6958656, rs10257460, rs12666532, rs1420422, rs17170915, rs10224438, rs7809365, rs6963276, rs6967358, rs6967403, rs10279544, rs4723619, rs17170163 rs2541089, rs2717975, rs10238916, rs2723952, rs12534004, rs2893540, rs2724006, rs2717983, rs27 17990, rs2701004, rs2724007, rs2717992, rs2723996, rs9655380, rs2701003, rs2717993, rs2724003, rs2723980, rs2723990, rs2717948, rs2700992, rs6462758, rs2724014, rs2724016, rs1882079, rs271794, rs13247953, rs23314 rs1647801, rs2052688, rs2052687, rs10282309, rs10239693, rs17261508, rs10267165, rs918979, rs7777258, rs11767227, rs1647791, rs1732001, rs17171045, rs9655382 and rs6952260, NCBI (v36.1) 3749522 etc. Never happen.
　ヒト第８染色体のTNKSを含む領域における多型部位としては、一塩基多型国際番号rs12680471、rs2085640、rs17149989、rs17730481、rs17663071、rs17663167、rs4841147、rs1458938、rs1458939、rs11786942、rs17674819、rs1466338、rs13253327、rs17150066、rs11777274、rs11249921、rs17150087、rs1380104、rs11997346、rs4841156、rs6991328、rs17150131、rs7817148、rs10100760、rs17150181、rs17150185、rs17733293、rs7835349、rs7013746、rs7016636、rs3989158、rs17150211、rs4841169、rs4841171、rs6985564、rs11991621、rs4840426、rs6992432、rs10503380、rs7013834、rs6980831、rs12681719、rs4840427、rs4841179、rs7832096、rs4474027、rs4457339、rs12674762、rs4535743、rs1393、rs4342598、rs11780274、rs13273033、rs4841197、rs7010270、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs11785739、rs17150478、rs11787443、rs2898223、rs7820917、rs7829463、rs7000483、rs1567837、rs17734290、rs12540961、rs7829733、rs2137790、rs13249584、rs7013686、rs7015101、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996、rs7828229、rs17150703、rs531564などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing TNKS of human chromosome 8, single nucleotide polymorphism international numbers rs12680471, rs2085640, rs17149989, rs17730481, rs17663071, rs17663167, rs4841147, rs1458938, rs1458939, rs11786942, rs17674819, rs1466338, rs13253327, rs17150066, rs11777274, rs11249921, rs17150087, rs1380104, rs11997346, rs4841156, rs6991328, rs17150131, rs7817148, rs10100760, rs17150181, rs17150185, rs17733293, rs7835349, rs7013746, rs7016636, rs3989158, rs1714, rs4841169 rs7013834, rs6980831, rs12681719, rs4840427, rs4841179, rs7832096, rs4474027, rs4457339, rs12674762, rs4535743, rs1393, rs4342598, rs11780274, rs13273033, rs4841197, rs7010270, rs4841200, rs9124, rs9124, rs7461939, rs9644 rs11787443, rs2898223, rs7820917, rs7829463, rs7000483, rs1567837, rs17734290, rs1254096 1, rs7829733, rs2137790, rs13249584, rs7013686, rs7015101, rs13270146, rs6601389, rs6601390, rs10098618, rs12056944, rs12543996, rs7828229, rs17150703, rs531564, and the like, but are not limited thereto.
　ヒト第８染色体のANGPT1を含む領域における多型部位としては、一塩基多型国際番号rs12549261、rs10955436、rs6981257、rs11774921、rs11781710、rs1954724、rs6997025、rs1892764、rs16875775、rs11778352、rs2584372、rs2246255、rs2022958、rs2022949、rs16875901、rs1010824、rs2507799、rs10505100、rs11777978、rs16875983、rs9297393、rs7009229、rs13257393、rs4077322、rs11997995、rs10505105、rs4133396、rs4133395、rs4341141、rs10505107、rs11780324、rs35143736、rs17368715、rs17296616、rs17368821、rs10955450、rs1433178、rs2514850、rs1283653、rs2445351、rs1283659、rs16876122、rs1632130、rs1672143、rs16876200、rs2514867、rs1283706、rs1283703、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191、rs1298936、rs1368497、rs1529747、rs2916085、rs1368494、rs3847160、rs1654680、rs17301273、rs10086467、rs16876325、rs1283720、rs1433171、rs1433172、rs10216767、rs1583300、rs281708、rs10955457、rs10103715、rs281673、rs439896、rs281685、rs281696、rs2014769、rs281740及びrs190735、NCBI(v36.1)108394240などを例示することができるが、これらに限定されることはない。 The polymorphic sites in the region containing ANGPT1 of human chromosome 8 include single nucleotide polymorphism international numbers rs12549261, rs10955436, rs6981257, rs11774921, rs11781710, rs1954724, rs6997025, rs1892764, rs16875775, rs11778352, rs2584372, rs2246255, rs2022958, rs2022949, rs16875901, rs1010824, rs2507799, rs10505100, rs11777978, rs16875983, rs9297393, rs7009229, rs13257393, rs4077322, rs11997995, rs10505105, rs4133396, rs4133395, rs4341141, rs10505107, rs11780324, rs351173 rs2445351, rs1283659, rs16876122, rs1632130, rs1672143, rs16876200, rs2514867, rs1283706, rs1283703, rs11785702, rs1283663, rs1283694, rs1433192, rs1433191, rs1298936, rs1368497, rs1529747, rs2916085, rs136876, rs1 rs1433171, rs1433172, rs10216767, rs1583300, rs281708, rs10955457, rs10103715, rs2816 73, rs439896, rs281685, rs281696, rs2014769, rs281740 and rs190735, NCBI (v36.1) 108394240, and the like, but are not limited thereto.
　ヒト第９染色体のPGM5を含む領域における多型部位としては、一塩基多型国際番号rs3869296、rs7020465、rs11142449、rs11142461、rs10868851、rs13439981、rs7039076、rs265083、rs2131355、rs265087、rs265073、rs7861495、rs10869020、rs17085775、rs11795256、rs10869034、rs1411992、rs10869043、rs12343877、rs11142941、rs869950、rs7046236、rs9644996などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing PGM5 of human chromosome 9 include single nucleotide polymorphism international numbers rs3869296, rs7020465, rs11142449, rs11142461, rs10868851, rs13439981, rs7039076, rs265083, rs2131355, rs265087, rs265073, rs7861495, rs10869020, rs17085775, Examples thereof include, but are not limited to, rs11795256, rs10869034, rs1411992, rs10869043, rs12343877, rs11142941, rs869950, rs7046236, rs9644996, and the like.
　ヒト第９染色体のTMC1を含む領域における多型部位としては、一塩基多型国際番号rs3012514、rs7846808、rs7027640、rs10781101、rs4526421、rs7853275、rs10869178、rs7864535、rs12004208、rs6560277、rs4573342、rs4132905、rs4073227、rs10121866、rs7044241、rs7855743、rs4373587、rs11143314、rs7047875、rs6560284、rs6560285、rs7857300、rs6560287、rs7866185、rs6560293、rs7026124、rs12346185、rs7041300、rs4307407、rs17095、rs10113863、rs7029452、rs6560297、rs7045535、rs13285932、rs10521449、rs13285999、rs10869190、rs9314799、rs1037031、rs2487471、rs2589623、rs2793153、rs2589615、rs969205、rs1796991、rs1838487、rs2589609、rs1663756、rs12351661、rs1663763、rs13298704、rs2501914などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing TMC1 of human chromosome 9 include single nucleotide polymorphism international numbers rs3012514, rs7846808, rs7027640, rs10781101, rs4526421, rs7853275, rs10869178, rs7864535, rs12004208, rs6560277, rs4573342, rs4132905, rs4073227, rs10121866, rs7044241, rs7855743, rs4373587, rs11143314, rs7047875, rs6560284, rs6560285, rs7857300, rs6560287, rs7866185, rs6560293, rs7026124, rs12346185, rs7041300, rs4307407, rs17095, rs10113863, rs705945, rs932, rs932, rs932 Examples thereof include, but are not limited to, rs1037031, rs2487471, rs2589623, rs2793153, rs2589615, rs969205, rs1796991, rs1838487, rs2589609, rs1663756, rs12351661, rs1663763, rs13298704, rs2501914, and the like.
　ヒト第９染色体のROR2を含む領域における多型部位としては、一塩基多型国際番号rs6479357、rs9409602、rs10991978、rs10991988、rs7867934、rs1388966、rs902923、rs902922、rs10512215、rs1532230、rs12337820、rs7029450、rs2131304、rs10992027、rs9299395、rs1388967、rs4073736、rs4073735、rs9409652、rs10992075、rs7031729、rs17585790、rs16907725、rs16907728、rs4372069、rs16907761、rs16907764、rs17586213、rs7039620、rs16907768、rs10992090、rs3802379、rs3935382、rs4601388、rs4744101、rs4743852、rs10119449、rs7858240、rs7022147、rs1569141、rs10992124、rs7856144、rs7855417、rs6479374、rs1881385、rs16907863、rs12002851、rs1881392、rs10992137、rs7045226、rs11789730、rs16907923、rs12684524、rs7858435、rs10116326、rs16907979、rs10992161、rs6479386、rs3858082、rs7038823、rs7871522、rs10125466、rs10992178、rs10820926、rs6479389、rs10820927、rs7867072、rs1954599、rs10992207などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing ROR2 of human chromosome 9 include single nucleotide polymorphism international numbers rs6479357, rs9409602, rs10991978, rs10991988, rs7867934, rs1388966, rs902923, rs902922, rs10512215, rs1532230, rs12337820, rs7029450, rs2131304, rs2920304, rs9299395, rs1388967, rs4073736, rs4073735, rs9409652, rs10992075, rs7031729, rs17585790, rs16907725, rs16907728, rs4372069, rs16907761, rs16907764, rs17586213, rs7039620, rs16907768, rs38023794, rs3802379, rs39338, rs3802379, rs393538 rs1569141, rs10992124, rs7856144, rs7855417, rs6479374, rs1881385, rs16907863, rs12002851, rs1881392, rs10992137, rs7045226, rs11789730, rs16907923, rs12684524, rs7858435, rs10116326, rs16907992, rs10992161, 8086492386, rs10992161, 8086492386 rs6479389, rs10820927, rs7867072, rs1954599, rs10992207, etc. That, but not be limited to these.
　ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位としては、一塩基多型国際番号rs7022663、rs7024526、rs2289631、rs10986505、rs16927802、rs12001999、rs10819019、rs6478690、rs1017530、rs3824507、rs12352758、rs4838242、rs650599、rs7860360、rs2113352、rs7019234、rs7867749、rs2271746、rs16927930、rs10986618、rs10986626、rs12237026、rs463774、rs420423、rs10986641、rs10513445、rs393721、rs10819043、rs10986689、rs10986698、rs10986703、rs10986714、rs10986715、rs10986721、rs10986722、rs1463837、rs4837016、rs10126025、rs10986738、rs2819624、rs3122938などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing PPP6C and / or C9orf126 of human chromosome 9 include single nucleotide polymorphism international numbers rs7022663, rs7024526, rs2289631, rs10986505, rs16927802, rs12001999, rs10819019, rs6478690, rs1017530, rs3824507, rs12352758, rs4838242, rs650599, rs7860360, rs2113352, rs7019234, rs7867749, rs2271746, rs16927930, rs10986618, rs10986626, rs12237026, rs463774, rs420423, rs10986641, rs10513445, rs393721, rs10819043, rs10986689, rs10986698, rs10986703, rs10986716 Although rs10126025, rs10986738, rs2819624, rs3122938, etc. can be illustrated, it is not limited to these.
　ヒト第１０染色体のGRID1を含む領域における多型部位としては、一塩基多型国際番号rs2202925、rs17306253、rs10887498、rs12243608、rs1876887、rs2457451、rs2664403、rs2664394、rs1912274、rs1912322、rs744413、rs2664406、rs2664405、rs2616673、rs2175200、rs2175201、rs17105725、rs1912277、rs2457450、rs17105747、rs746992、rs7076174、rs4027581、rs11201743、rs4418740、rs17105793、rs12221324、rs17105805、rs7924009、rs11201759、rs11201775、rs3011700、rs2949380、rs17105842、rs3011704、rs2140661、rs1917136、rs17105866、rs1880389、rs884316、rs2949384、rs2949385、rs2140666、rs2949386、rs1106789、rs11201804、rs17105912、rs17105916、rs2352181、rs947596、rs2352099、rs7924131、rs7923188、rs7923344、rs1418396、rs7899222、rs10788472、rs10887538、rs2153828、rs7910835、rs7914815、rs7918491、rs2001417、rs2001416、rs10887540、rs7095652、rs12773130、rs12779841、rs10887544、rs11201871、rs10887549、rs10788476、rs2003111、rs7912451、rs11201882、rs2352178、rs7923926、rs7082134、rs4284352、rs6585995、rs6585996、rs5003944、rs7923310、rs884700、rs4934156、rs11201909、rs868042、rs12257526、rs12262754、rs11817682、rs12243396、rs1870156、rs2607830、rs17320915、rs2814322、rs2607840、rs11201944、rs17106434、rs2607822、rs10887563、rs10887564、rs2492738、rs1870161、rs2607839、rs1870165、rs2814340、rs1902678、rs2814349、rs1947567、rs2168725、rs1902680、rs2607833、rs1902676、rs1896527、rs6586003、rs12262612、rs6586004、rs17106584、rs7905184、rs10887578、rs10509530、rs1078789、rs10749537、rs12355013、rs7904985、rs10788500、rs10788501、rs10458771、rs2018507、rs10887608、rs4934207、rs4934208、rs7083506などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing GRID1 of human chromosome 10, single nucleotide polymorphism international numbers rs2202925, rs17306253, rs10887498, rs12243608, rs1876887, rs2457451, rs2664403, rs2664394, rs1912274, rs1912322, rs744413, rs2664406, rs2664405, rs2616673, rs2175200, rs2175201, rs17105725, rs1912277, rs2457450, rs17105747, rs746992, rs7076174, rs4027581, rs11201743, rs4418740, rs17105793, rs12221324, rs17105805, rs7924009, rs11201759, rs11201775, rs11 rs884316, rs2949384, rs2949385, rs2140666, rs2949386, rs1106789, rs11201804, rs17105912, rs17105916, rs2352181, rs947596, rs2352099, rs7924131, rs7923188, rs7923344, rs1418396, rs7899222, rs10788472, rs10887538, 7910 rs10887540, rs7095652, rs12773130, rs12779841, rs10887544, rs11201871, rs10887549, rs10788476 rs2003111, rs7912451, rs11201882, rs2352178, rs7923926, rs7082134, rs4284352, rs6585995, rs6585996, rs5003944, rs7923310, rs884700, rs4934156, rs11201909, rs868042, rs12257526, rs12262754, rs1 1732, rs12243396, rs1 rs17106434, rs2607822, rs10887563, rs10887564, rs2492738, rs1870161, rs2607839, rs1870165, rs2814340, rs1902678, rs2814349, rs1947567, rs2168725, rs1902680, rs2607833, rs1902676, rs1896527, rs6586003, rs12262610rs, 658 Examples include, but are not limited to, rs10749537, rs12355013, rs7904985, rs10788500, rs10788501, rs10458771, rs2018507, rs10887608, rs4934207, rs4934208, rs7083506, and the like.
　ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位としては、一塩基多型国際番号rs7124648、rs7128650、rs4587689、rs11039097、rs12796744、rs17197619、rs17790390、rs11039105、rs10501319、rs11039112、rs747650、rs7937410、rs17197710、rs1685404、rs2013867、rs901746、rs7118396、rs10838681、rs10501321、rs1051006、rs3816724、rs7124955、rs4752824、rs1052373、rs11570094、rs10769255、rs11039212、rs4992357、rs11605672、rs1534576、rs10742805、rs12419692、rs4752856、rs3817334、rs7120548、rs10838739、rs11039329、rs10742817、rs4752791、rs17788930、rs7114011、rs10838774、rs2305982、rs6485788、rs10838782、rs7924699、rs1872167、rs747782、rs1681630などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160) include single nucleotide polymorphism international numbers rs7124648, rs7128650, rs4587689 , Rs11039097, rs12796744, rs17197619, rs17790390, rs11039105, rs10501319, rs11039112, rs747650, rs7937410, rs17197710, rs1685404, rs2013867, rs901746, rs7118396, rs10838681, rs10501321, rs1051006, rs3816724, rs7124955, rs47510, rs7124955, rs47510 Rs11605672, rs1534576, rs10742805, rs12419692, rs4752856, rs3817334, rs7120548, rs10838739, rs11039329, rs10742817, rs4752791, rs17788930, rs7114011, rs10838774, rs2305982, rs6485788, rs10838782, rs7924699, 168 However, it is not limited to these.
　ヒト第１１染色体のOR5R1を含む領域における多型部位としては、一塩基多型国際番号rs1586004、rs7940239、rs10896302、rs17615246、rs10750820、rs1945245、rs3938998、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs1945213、rs1945211、rs7113069、rs11228306、rs12785840、rs10501353、rs1945203、rs585475、rs615231、rs617315、rs675991、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594、rs634955、rs613050などを例示することができるが、これらに限定されることはない。 The polymorphic sites in the region containing OR5R1 of human chromosome 11 include single nucleotide polymorphism international numbers rs1586004, rs7940239, rs10896302, rs17615246, rs10750820, rs1945245, rs3938998, rs10791979, rs1573511, rs12277883, rs7116573, rs10896333, rs4420287, rs1894026, rs1945213, rs1945211, rs7113069, rs11228306, rs12785840, rs10501353, rs1945203, rs585475, rs615231, rs617315, rs675991, rs7939886, rs4939052, rs621957, rs611534, rs594854, rs618594, rs634955, rs613050, etc. Never happen.
　ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位としては、一塩基多型国際番号rs1026250、rs10750931、rs7126121、rs11230241、rs10897026、rs12225299、rs10792264、rs7125753、rs11605188、rs1899571、rs11230258、rs11230261、rs7943967、rs4442568、rs10897047、rs2868121、rs7945665、rs10897049、rs4506675、rs10792267、rs2304935、rs2165832、rs10736703、rs4939347、rs2233244、rs950803、rs950802、rs3816270、rs2241920、rs10501383、s10897056、rs4939352、rs955019、rs4938943、rs11230304、rs3763850、rs2282524、rs10897061、rs2120182、rs12787520、rs4146870、rs4939364、rs1051756、rs1941032、rs17615252、rs17543397、rs8181503、rs7946021、rs4939391、rs2186919、rs2847222、rs2633277及びrs2847212、NCBI(v36.1)59954904などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing human chromosome 11 MS4A7 and / or MS4A14, single nucleotide polymorphism international numbers rs1026250, rs10750931, rs7126121, rs11230241, rs10897026, rs12225299, rs10792264, rs7125753, rs11605188, rs1899571, rs11230258, rs11230261, rs7943967, rs4442568, rs10897047, rs10886847, rs2868121, rs7945665, rs10897049, rs4506675, rs10792267, rs2304935, rs2165832, rs10736703, rs4939347, rs2233244, rs950803, rs950802, rs3816270, rs2241920, rs10501383, rs10897056, rs4933850 rs10897061, rs2120182, rs12787520, rs4146870, rs4939364, rs1051756, rs1941032, rs17615252, rs17543397, rs8181503, rs7946021, rs4939391, rs2186919, rs2847222, rs2633277 and rs2847212, NCBI (v36.1) 59954904, etc. There is no limit.
　ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位としては、一塩基多型国際番号rs565976、rs534179、rs2276443、rs532454、rs511190、rs566818、rs482458、rs1793412、rs1790149、rs1790155、rs1790154、rs668727、rs11600640、rs611449、rs11236449、rs661928、rs621305、rs11236452、rs7128888、rs7129014、rs688727、rs674503、rs606452、rs11236458、rs599816、rs660343、rs541993、rs601142、rs648930、rs611221、rs12574551、rs584046、rs640927、rs11236476、rs17134231、rs12282340、rs10160335、rs12281880、rs656007、rs479592、rs589443、rs4944086、rs10751245、rs7110142、rs7947980及びrs509530、NCBI(v36.1)75005360などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 include single nucleotide polymorphism international numbers rs565976, rs534179, rs2276443, rs532454, rs511190, rs566818, rs482458, rs1793412, rs1790149, rs1790155, rs1790154, rs668727, rs11600640, rs611449, rs11236449, rs661928, rs621305, rs11236452, rs7128888, rs7129014, rs688727, rs674503, rs606452, rs11236458, rs599816, rs660343, rs541993, rs601142, rs648930, rs611221, rs1257446, rs5 Examples thereof include, but are not limited to, rs12282340, rs10160335, rs12281880, rs656007, rs479592, rs589443, rs4944086, rs10751245, rs7110142, rs7947980, rs509530, NCBI (v36.1) 75005360, and the like.
　ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位としては、一塩基多型国際番号rs17120344、rs6589597、rs10790175、rs12420127、rs10892082、rs7107152、rs1242229、rs1784042、rs2269399、rs526602、rs664971、rs11216315、rs1263499、rs17120523、rs236919、rs528508、rs593245及びrs477036、NCBI(v36.1)116617736などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 include single nucleotide polymorphism international numbers rs17120344, rs6589597, rs10790175, rs12420127, rs10892082, rs7107152, rs1242229, rs1784042, rs2269399 , Rs526602, rs664971, rs11216315, rs1263499, rs17120523, rs236919, rs528508, rs593245 and rs477036, NCBI (v36.1) 116617736, and the like, but are not limited thereto.
　ヒト第１２染色体のTAOK3を含む領域における多型部位としては、一塩基多型国際番号rs7297299、rs5745807、rs5745811、rs9739560、rs4767654、rs10638、rs9788041、rs11068799、rs11068803、rs10850953、rs7135008、rs11613924、rs7307331、rs9669474、rs7957463、rs10850956、rs2936840、rs904661、rs1726407、rs1726392、rs17440336、rs1277442、rs11068860、rs11068865、rs17512142、rs17440364、rs364823、rs418941、rs7974718、rs11068891、rs16948230、rs404566、rs16948234、rs17512483、rs17512574、rs2271007、rs11068937、rs7966814、rs6490178、rs905579、rs983421、rs1503767、rs7132650、rs7316050などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing TAOK3 of human chromosome 12 include single nucleotide polymorphism international numbers rs7297299, rs5745807, rs5745811, rs9739560, rs4767654, rs10638, rs9788041, rs11068799, rs11068803, rs10850953, rs7135008, rs11613924, rs7307331, rs9667334, rs7957463, rs10850956, rs2936840, rs904661, rs1726407, rs1726392, rs17440336, rs1277442, rs11068860, rs11068865, rs17512142, rs17440364, rs364823, rs418941, rs7974718, rs11068891, rs16948230, rs404566, rs16948234, rs17579 Examples include rs905579, rs983421, rs1503767, rs7132650, and rs7316050, but are not limited thereto.
　ヒト第１２染色体のSTX2を含む領域における多型部位としては、一塩基多型国際番号rs7964173、rs11061064、rs10848174、rs7965385、rs7979388、rs7953972、rs4759749、rs4759751、rs7308461、rs1881062、rs10083153、rs729463、rs1881067、rs2695872、rs10848193、rs10848194、rs7305915、rs2398529、rs3864899、rs4412792、rs2632601、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483、rs1609985、rs10848218、rs11061198、rs7307055、rs11061209、rs10773833、rs11061222、rs7299940、rs2141182、rs1405904、rs1316893、rs4074922、rs4388928などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing STX2 of human chromosome 12, single nucleotide polymorphism international numbers rs7964173, rs11061064, rs10848174, rs7965385, rs7979388, rs7953972, rs4759749, rs4759751, rs7308461, rs1881062, rs10083153, rs729463, rs1881067, rs2695872, rs10848193, rs10848194, rs7305915, rs2398529, rs3864899, rs4412792, rs2632601, rs1554807, rs10848205, rs2037789, rs4619189, rs2001483, rs1609985, rs10848218, rs11061198, rs7307055, rs11061209, rs10612833, rs1106121 However, the present invention is not limited to these examples.
　ヒト第１３染色体のCARS2を含む領域における多型部位としては、一塩基多型国際番号rs9521809、rs4773201、rs1106649、rs9521814、rs385037、rs7997619、rs912941、s1886871、rs2182271、rs912942、rs331596、rs9559844、rs331602、rs1536621、rs9521853、rs9559849、rs7999854、rs3858821、rs4771696、rs4773228、rs4773229、rs2765341、rs3742193、rs3742194、rs7323602、rs3759463、rs179356、rs330565、rs7394、rs389656、rs450514、rs445490、rs418321、rs2251314、rs2165418、rs7999702、rs9521926、rs3098728、rs9515279及びrs2582886、NCBI(v36.1)110097814などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region including CARS2 of human chromosome 13 include single nucleotide polymorphism international numbers rs9521809, rs4773201, rs1106649, rs9521814, rs385037, rs7997619, rs912941, s1886871, rs2182271, rs912942, rs331596, rs9559844, rs331602, rs1536621, rs9521853, rs9559849, rs7999854, rs3858821, rs4771696, rs4773228, rs4773229, rs2765341, rs3742193, rs3742194, rs7323602, rs3759463, rs179356, rs330565, rs7394, rs389656, rs450514, rs445490, rs418970, rs2251314, rs2165 Examples include rs2582886 and NCBI (v36.1) 110097814, but are not limited thereto.
　ヒト第１５染色体のCYP19A1を含む領域における多型部位としては、一塩基多型国際番号rs6493469、rs12595526、rs8031702、rs17599974、rs16953045、rs10744956、rs2306335、rs6493470、rs7181201、rs11856609、rs1124769、rs17647040、rs12899586、rs12904155、rs7170455、rs7177664、rs8040954、rs17647084、rs4775916、rs1111266、rs16964077、rs1025738、rs7179084、rs7176579、rs16964113、rs10519293、rs17522553、rs12324478、rs1075681、rs2899469、rs8031580、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs16964201、rs12595627、rs8023263、rs2899473、rs700518、rs3759811、rs17703883、rs1865803、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs1062033、rs2008691、rs11636403、rs10519299、rs17647707、rs17647719、rs7167343、rs936308、rs12594203、rs999480、rs2290622、rs8031463、rs6493495、rs2445765、rs2445766、rs2445768、rs1551656、rs12441382、rs2446420、rs2124873、rs2470184、rs2470187、rs2445781、rs12595284、rs17647970、rs7174434、rs764530、rs12438104、rs16964308、rs4775942、rs16964316、rs2470172、rs2470173、rs16964319、rs10163098、rs12443092、rs2168623、rs3751586、rs2445741、rs8036694、rs2459396及びrs16964348、NCBI(v36.1)49383121などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing CYP19A1 of human chromosome 15 include single nucleotide polymorphism international numbers rs6493469, rs12595526, rs8031702, rs17599974, rs16953045, rs10744956, rs2306335, rs6493470, rs7181201, rs11856609, rs1124769, rs17647040, rs12899586, rs12904155, rs7170455, rs7177664, rs8040954, rs17647084, rs4775916, rs1111266, rs16964077, rs1025738, rs7179084, rs7176579, rs16964113, rs10519293, rs17522553, rs12324478, rs1075681, rs2899469, rs8031580, rs8029120, rs47745895, rs47710564 rs2899473, rs700518, rs3759811, rs17703883, rs1865803, rs4775936, rs10459592, rs17523270, rs10519297, rs11636686, rs11636667, rs1062033, rs2008691, rs11636403, rs10519299, rs17647707, rs1763 480, 495, rs203 rs2445766, rs2445768, rs1551656, rs12441382, rs2446420, rs2124873, rs2470184, rs247 0187, rs2445781, rs12595284, rs17647970, rs7174434, rs764530, rs12438104, rs16964308, rs4775942, rs16964316, rs2470172, rs2470173, rs16964319, rs10163098, rs12443092, rs2168623, rs3751586, rs2445741, rs64596.1, rs8036694, 1692459396) However, it is not limited to these.
　ヒト第１７染色体のCA10を含む領域における多型部位としては、一塩基多型国際番号rs4794268、rs4794274、rs4399573、rs12051837、rs6504736、rs7208167、rs9303589、rs1468118、rs10491154、rs17695254、rs2073864、rs9912472、rs3764798、rs17695921、rs11867674、rs886078、rs8076197、rs8076496、rs2073866、rs9901183、rs4794293、rs8064617、rs4794294、rs985758、rs4794295、rs16950363、rs2873938、rs1263962、rs1263965、rs1263988、rs1263989、rs4794298、rs4794300、rs8080331、rs11869209、rs1269480、rs1263978、rs1003290、rs1263981、rs1405191、rs1263984、rs9904076、rs4794304、rs8074185、rs6504747、rs16950512、rs7223782、rs4794305、rs16950534、rs1526182、rs1501255、rs4496207、rs1125750、rs1405187、rs767326、rs981577、rs4794307、rs202133、rs16950626、rs9896969、rs202136、rs202121、rs202120、rs203076、rs203090、rs203092、rs203093、rs203097、rs203098、rs10514990、rs203010、rs10514991、rs203022、rs6504754、rs12603762、rs169386、rs203042、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs203002、rs1005092、rs9896168、rs8065627、rs16950939、rs2907784、rs11079991、rs1393735、rs2970016、rs1875675、rs2938139、rs1354275、rs7224915、rs9893317、rs1503059、rs2970052、rs11655715、rs1155218、rs2931368、rs2931365、rs2931364、rs9908649、rs1486745、rs4605214、rs1503041、rs10514997、rs10514998、rs11079993、rs1503050、rs1503051、rs10515000、rs12949235、rs1393734、rs17678475、rs16951169、rs12150128、rs16951176、rs16951177、rs9903651、rs10515001、rs1847245、rs12150499、rs6504764などを例示することができるが、これらに限定されることはない。 As polymorphic sites in the region containing CA10 of human chromosome 17, the single nucleotide polymorphism international numbers rs4794268, rs4794274, rs4399573, rs12051837, rs6504736, rs7208167, rs9303589, rs1468118, rs10491154, rs17695254, rs2073864, rs9912472, rs3764798, rs17695921, rs11867674, rs886078, rs8076197, rs8076496, rs2073866, rs9901183, rs4794293, rs8064617, rs4794294, rs985758, rs4794295, rs16950363, rs2873938, rs1263962, rs1263965, rs1263988, rs4793298, rs3314300, rs0 rs1405191, rs1263984, rs9904076, rs4794304, rs8074185, rs6504747, rs16950512, rs7223782, rs4794305, rs16950534, rs1526182, rs1501255, rs4496207, rs1125750, rs1405187, rs767326, rs47915307, rs202133, 20216, rs202133, 20216, rs202133, 20216 rs203090, rs203092, rs203093, rs203097, rs203098, rs10514990, rs203010, rs10514991, rs203022, rs6504754, r s12603762, rs169386, rs203042, rs7215008, rs996379, rs4794315, rs4794315, rs2031253, rs203050, rs203002, rs1005092, rs9896168, rs8065627, rs16950939, rs2907784, rs11079991, rs1393735, rs2970016, rs1875675, rs2938139, rs1354275, 59 rs1155218, rs2931368, rs2931365, rs2931364, rs9908649, rs1486745, rs4605214, rs1503041, rs10514997, rs10514998, rs11079993, rs1503050, rs1503051, rs10515000, rs12949235, rs1393734, rs17678475, rs16951169, rs12150128, rs12150128, rs12176128 Examples include rs6504764, but are not limited thereto.
　ヒト第１８染色体のLOC643542を含む領域における多型部位としては、一塩基多型国際番号rs8086948、rs12457951、rs11151371、rs17077389、rs1480679、rs5000099、rs1480682、rs433411、rs370944、rs395074、rs379982、rs281571、rs1444106、rs2448716、rs1562072、rs1867412、rs17077583、rs764133、rs17828615、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112、rs2448755、rs2448745、rs2440527、rs28379561、rs10503118、rs1562070、rs2448727、rs17077858、rs12605273、rs2440540、rs4127445、rs7231324、rs12964913、rs9319739、rs17077963、rs12954315、rs4127447、rs7243836、rs8085641、rs2054299、rs515540、rs519360、rs17078114、rs2613163、rs652082、rs638006、rs3911662、rs12966846、rs3845265、rs11661918、rs11151403、rs9953435などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing LOC643542 of human chromosome 18 include single nucleotide polymorphism international numbers rs8086948, rs12457951, rs11151371, rs17077389, rs1480679, rs5000099, rs1480682, rs433411, rs370944, rs395074, rs379982, rs281571, rs1444106, rs2448716, rs1562072, rs1867412, rs17077583, rs764133, rs17828615, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112, rs2448755, rs2448745, rs2440527, rs28379561, rs10503118, rs1562070, rs2448727, rs17027313 Examples include rs17077963, rs12954315, rs4127447, rs7243836, rs8085641, rs2054299, rs515540, rs519360, rs17078114, rs2613163, rs652082, rs638006, rs3911662, rs12966846, rs3845265, rs11661918, rs11151403, rs9953435, etc. There is no.
　ヒト第２０染色体のPTPRTを含む領域における多型部位としては、一塩基多型国際番号rs1884029、rs6072606、rs2207220、rs4812571、rs4572656、rs2013923、rs4812574、rs6513762、rs6513763、rs6029950、rs2144009、rs2866941、rs6102658、rs2144011、rs3787282、rs746413、rs4812578、rs6102671、rs1126101、rs6065434、rs4810352、rs1076666、rs6029980、rs6016688、rs2076249、rs17221018、rs17221067、rs17312515、rs17221137、rs6130047、rs16986551、rs17221326、rs16986558、rs12625871、rs6016698、rs6030014、rs17221823、rs1883377、rs6016705、rs2179336、rs2143008、rs6030030、rs2206169、rs6102713、rs6093598、rs6030070、rs6030071、rs1014757、rs2143632、rs6030076、rs16986712、rs727337、rs727336、rs6030096、rs11906485、rs2867026、rs16986733、rs11698118、rs6124439、rs11696306、rs1016071、rs6030124、rs1573707、rs6016745、rs12481463、rs4812588、rs6102795、rs11697499、rs4812591、rs916327、rs1883269、rs16986850、rs1033414、rs11700137、rs6072747、rs999114、rs999113、rs6016798、rs2076082、rs6065482、rs6065484、rs6065487、rs6130145、rs230153、rs230154、rs172981、rs230155、rs6072758、rs230157、rs6124468、rs6102880、rs6130153、rs6065504、rs6065509、rs6072789、rs1033643、rs13040647、rs16987042、rs6030322、rs6072792、rs4482557、rs6130168、rs6030341、rs17747544、rs6065515、rs1883843、rs8119203、rs10854226、rs6102929、rs8121443、rs6030363、rs6102950、rs2867488、rs7360934、rs909863、rs6030370、rs6030380、rs6030381、rs9974028、rs6093705、rs6030385、rs6102967、rs2223542、rs6030395、rs6065520、rs6072814、rs2206426、rs6016864、rs6072819、rs6030407、rs6065525、rs2425520、rs2425530、rs4812631、rs4810366、rs2017914、rs3092557、rs17749109、rs4812637、rs6030442、rs6030443、rs1018407、rs6016884、rs1022819、rs733976、rs6030456、rs6093729、rs6030462、rs17749217、rs2146615、rs8119733、rs13042473、rs6103041、rs1973949、rs208256、rs208254、rs3092043、rs2077768、rs208250、rs4812645、rs6130222、rs4812655、rs6130232、rs208230、rs208229、rs6065544、rs6065545、rs6065546、rs7262282、rs7262355、rs11699742、rs8125304、rs6065547、rs4812659、rs16987493、rs208272、rs208273、rs4315585、rs208186、rs208197、rs206636、rs6030572、rs4812664、rs4812665、rs16987668、rs206148、rs206154、rs206159、rs206163、rs2208048、rs2425546、rs2425553、rs2425554、rs2425560、rs2425562、rs1106978、rs6030634、rs6016951、rs1006746、rs2425587、rs927058、rs2425593、rs2425599、rs2425610、rs16987770、rs6016963、rs6065579、rs1572929、rs6072998、rs6030670、rs947202、rs947203、rs4812681、rs6093784、rs4812683、rs10485698、rs926288、rs1569445、rs6030689、rs2867656、rs11699547、rs6030709及びrs7267873、NCBI(v36.1)40130174などを例示することができるが、これらに限定されることはない。 Examples of polymorphic sites in the region containing PTPRT of human chromosome 20 include single nucleotide polymorphism international numbers rs1884029, rs6072606, rs2207220, rs4812571, rs4572656, rs2013923, rs4812574, rs6513762, rs6513763, rs6029950, rs2144009, rs2866941, rs6102658, rs2144011, rs3787282, rs746413, rs4812578, rs6102671, rs1126101, rs6065434, rs4810352, rs1076666, rs6029980, rs6016688, rs2076249, rs17221018, rs17221067, rs17312515, rs17221137, rs6130047, rs16986551, rs17221326, rs16986558, rs12671 rs2179336, rs2143008, rs6030030, rs2206169, rs6102713, rs6093598, rs6030070, rs6030071, rs1014757, rs2143632, rs6030076, rs16986712, rs727337, rs727336, rs6030096, rs11906485, rs2867026, rs16986733, rs11698118, rs6124439, 60711 rs12481463, rs4812588, rs6102795, rs11697499, rs4812591, rs916327, rs1883269, rs16986850, rs10334 14, rs11700137, rs6072747, rs999114, rs999113, rs6016798, rs2076082, rs6065482, rs6065484, rs6065487, rs6130145, rs230153, rs230154, rs172981, rs230155, rs6072758, rs230157, rs6124468, rs6102880, rs6130153, rs60650 rs16987042, rs6030322, rs6072792, rs4482557, rs6130168, rs6030341, rs17747544, rs6065515, rs1883843, rs8119203, rs10854226, rs6102929, rs8121443, rs6030363, rs6102950, rs2867488, rs7360934, rs30863, rs6030370, 705 rs2223542, rs6030395, rs6065520, rs6072814, rs2206426, rs6016864, rs6072819, rs6030407, rs6065525, rs2425520, rs2425530, rs4812631, rs4810366, rs2017914, rs3092557, rs17749109, rs4812637, rs4030, rs6030443, rs10 rs6030462, rs17749217, rs2146615, rs8119733, rs13042473, rs6103041, rs1973949, rs208256, rs208254, rs 3092043, rs2077768, rs208250, rs4812645, rs6130222, rs4812655, rs6130232, rs208230, rs208229, rs6065544, rs6065545, rs6065546, rs7262282, rs7262355, rs11699742, rs8125304, rs6065547, rs4812659, rs16987493, rs208272, rs208 rs6030572, rs4812664, rs4812665, rs16987668, rs206148, rs206154, rs206159, rs206163, rs2208048, rs2425546, rs2425553, rs2425554, rs2425560, rs2425562, rs1106978, rs6030634, rs6016951, rs1006746, rs2425587, rs24593696 Examples include rs6065579, rs1572929, rs6072998, rs6030670, rs947202, rs947203, rs947126, rs4812681, rs6093784, rs4812683, rs10485698, rs926288, rs1569445, rs6030689, rs2867656, rs11699547, rs6030709 and rs7267873, NCBI (v36.1) 40130174, etc. It is not limited to these.
　ヒト第２１染色体のITSN1を含む領域における多型部位としては、一塩基多型国際番号rs12626309、rs2834231、rs4817579、rs2834238、rs2211689、rs2834246、rs2834251、rs2834252、rs1537097、rs1892589、rs2073368、rs2409499、rs9978415、rs2268247、rs9979937、rs2834264、rs2834268、rs879261、rs2245099、rs1108000、rs9979150、rs743316、rs2300384、rs3746861、rs2834292、rs2834295、rs2040113、rs2834296、rs2834297、rs2239565、rs17655810、rs12626410、rs2834303、rs2236645、rs2834310、rs16991110、rs2070513、rs2032312、rs2032313、rs2834315、rs11088265、rs17730050、rs2834332などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing ITSN1 of human chromosome 21 include single nucleotide polymorphism international numbers rs12626309, rs2834231, rs4817579, rs2834238, rs2211689, rs2834246, rs2834251, rs2834252, rs1537097, rs1892589, rs2073368, rs2409499, rs9978415, rs2268247, rs9979937, rs2834264, rs2834268, rs8794268, rs879261, rs2245099, rs1108000, rs9979150, rs743316, rs2300384, rs3746861, rs2834292, rs2834295, rs2040113, rs2834296, rs2834297, rs2239565, rs17655810, rs12626413, rs2834303, rs2 320 Examples thereof include, but are not limited to, rs2834315, rs11088265, rs17730050, and rs2834332.
　ヒト第２染色体のLRP2を含む領域における多型部位としては、一塩基多型国際番号rs13416802、rs2287616、rs2287613、rs3770597、rs10200158、rs6761690、rs13430236、rs3814381、rs4148765、rs10490134、rs11902639、rs10183805、rs13403114、rs3815574、rs2302698、rs6750251、rs4667590、rs4668121、rs1990702、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs11679947、rs10490132、rs2239602、rs2024481、rs741378、rs2284679、rs4287730、rs10210408、rs1548936、rs3770604、rs2075248、rs10490131、rs10169232、rs2239600、rs2284675、rs2268373、rs2268372、rs2193193、rs2268370、rs6747692、rs2300445、rs2239598、rs2239597、rs2239596、rs2239594、rs830957、rs830959、rs12988804、rs831002、rs16856748、rs11887007、rs16856759、rs830964、rs830971、rs830972、rs2247506、rs3845731、rs3770636、rs2673172、rs6713072、rs1990842、rs10199676、rs830955、rs12616998、rs12613663、rs10930354、rs4281872、rs12052892などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing LRP2 of human chromosome 2 include single nucleotide polymorphism international numbers rs13416802, rs2287616, rs2287613, rs3770597, rs10200158, rs6761690, rs13430236, rs3814381, rs4148765, rs10490134, rs11902639, rs10183805, rs13403114, rs3815574, rs2302698, rs6750251, rs4667590, rs4668121, rs1990702, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs11679947, rs10490132, rs2239602, rs2024481, rs741378, rs2284679, rs4287730, rs10210408, rs193610 rs2284675, rs2268373, rs2268372, rs2193193, rs2268370, rs6747692, rs2300445, rs2239598, rs2239597, rs2239596, rs2239594, rs830957, rs830959, rs12988804, rs831002, rs16856748, rs11887007, rs830964, 3178301, rs830964, rs830971, rs830964, rs830971 rs6713072, rs1990842, rs10199676, rs830955, rs12616998, rs12613663, rs10930354, rs4281872, rs12052892 It can be exemplified, but not limited thereto.
　ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位としては、一塩基多型国際番号rs523246、rs10501136、rs836950、rs12808574、rs10836315、rs502857、rs731726、rs731727、rs967751、rs1553760、rs1396880、rs2941043、rs2941042、rs2941061、rs2956079、rs2941054、rs1509662、rs2941052、rs2915234、rs891550、rs919554、rs2915232、rs2956086、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986425、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs984690、rs3763934、rs10488801、rs2956106、rs11032927、rs2915202、rs2915201、rs2915199、rs1998912、rs2915193、rs11032937、rs2915227、rs2732557、rs10836326、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs1409716、rs2762955、rs952489、rs514182、rs1425806、rs2732528、rs2553794、rs2553793、rs678137、rs2785156、rs2553787、rs737503、rs737502、rs2162159、rs2732552、rs387619、rs10836332、rs353610、rs353605、rs2785189、rs2553822、rs11032995、rs12291631、rs353590、rs353589、rs353587、rs1559759、rs4756190、rs353581、rs7106681、rs507230、rs634096、rs2732578、rs404977、rs4756191、rs2785180などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing APIP and / or PDHX of human chromosome 11 include single nucleotide polymorphism international numbers rs523246, rs10501136, rs836950, rs12808574, rs10836315, rs502857, rs731726, rs731727, rs967751, rs1553760, rs1396880, rs2941043, rs2941042, rs2941061, rs2956079, rs2941054, rs1509662, rs2941052, rs2915234, rs891550, rs919554, rs2915232, rs2956086, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs3751078, 291513, rs3751078, rs2915 rs1326942, rs2986429, rs2915217, rs7111607, rs2915214, rs984690, rs3763934, rs10488801, rs2956106, rs11032927, rs2915202, rs2915201, rs2915199, rs1998912, rs2915193, rs11032937, rs2915227, rs2732557, rs10836326, 488 rs2762955, rs952489, rs514182, rs1425806, rs2732528, rs2553794, rs2553793, rs678137, rs2785156, rs2553787, rs737503 , Rs737502, rs2162159, rs2732552, rs387619, rs10836332, rs353610, rs353605, rs2785189, rs2553822, rs11032995, rs12291631, rs353590, rs353589, rs353587, rs1559759, rs4756190, rs353581, rs7106681, rs5072578, rs634096rs40, 475 Although it can illustrate, it is not limited to these.
　ヒト第１２染色体のCUX2を含む領域における多型部位としては、一塩基多型国際番号rs7979656、rs10849918、rs2106407、rs2106406、rs12425190、rs11065783、rs2339706、rs4509829、rs7961663、rs4766526、rs4766442、rs4766443、rs12815195、rs12229654、rs756825、rs16941284、rs6489979、rs4766553、rs9783423、rs7952972、rs16941319、rs3809290、rs7962233、rs4766451、rs886126、rs2078851、rs1265566、rs2301658、rs7300082、rs7300860、rs16941414、rs7398833、rs16941437、rs10849946、rs2078863、rs11065898などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing CUX2 of human chromosome 12 include single nucleotide polymorphism international numbers rs7979656, rs10849918, rs2106407, rs2106406, rs12425190, rs11065783, rs2339706, rs4509829, rs7961663, rs4766526, rs4766442, rs4766443, rs12815195, rs12229654, rs756825, rs16941284, rs6489979, rs4766553, rs9783423, rs7952972, rs16941319, rs3809290, rs7962233, rs4766451, rs886126, rs2078851, rs1265566, rs2301658, rs7300082, rs7300860, rs16941414, rs7398833, rs16941437, rs10849946, 110 However, it is not limited to these.
　ヒト第１７染色体のTOM1L1を含む領域における多型部位としては、一塩基多型国際番号rs2332297、rs2934884、rs16955216、rs2934890、rs7225247、rs16955225、rs9303359、rs7207731、rs17683089、rs11658131、rs2958944、rs2934909、rs2934914、rs2934921、rs2958933、rs7221313、rs7210248、rs2958921、rs8079105、rs16955327、rs12949718、rs9899602、rs17745123、rs8070668、rs9910653、rs17817829、rs12936860、rs12951898、rs17817950及びrs2787501、NCBI(v36.1)50344775などを例示することができるが、これらに限定されることはない。 Polymorphic sites in the region containing TOM1L1 of human chromosome 17 include single nucleotide polymorphism international numbers rs2332297, rs2934884, rs16955216, rs2934890, rs7225247, rs16955225, rs9303359, rs7207731, rs17683089, rs11658131, rs2958944, rs2934909, rs2934914, rs2934921, rs2958933, rs7221313, rs7210248, rs2958921, rs8079105, rs16955327, rs12949718, rs9899602, rs17745123, rs8070668, rs9910653, rs17817829, rs12936860, rs12951898, rs17817950, rs2787501, NCBI (v36.1) 50344775, etc. There is no limit.
　本明細書において、一塩基多型(SNP)は、dbSNPデータベースにおけるrs番号又はNCBI(v36.1)番号で示す。 In this specification, the single nucleotide polymorphism (SNP) is indicated by the rs number or NCBI (v36.1) number in the dbSNP database.
　本明細書において、「正常眼圧緑内障の検査」とは、被検者が正常眼圧緑内障に罹患する可能性が高いか低いかを判定するための検査、すでに被検者が正常眼圧緑内障に罹患している場合にはその確定診断を行うための検査が含まれる。 In the present specification, “normal tension glaucoma examination” is an examination for determining whether or not a subject has a high or low possibility of having normal tension glaucoma. Tests to make a definitive diagnosis are included.
　本発明の検査方法における「多型部位」は、遺伝子のＯＲＦ中、遺伝子の発現を制御する領域（例えば、プロモーター領域、エンハンサー領域等）中、遺伝子のイントロン中、あるいはこれら遺伝子と連鎖不平衡にあるその前後の領域に存在しうる。多型の種類としては、例えば、一塩基多型、一から数十塩基（時には数千塩基）が置換、欠失、挿入、転移あるいは逆位している多型などが挙げられるが、これらに特に限定されない。さらに、多型部位の数も、1個に限定されず、複数個であってもよい。 The “polymorphic site” in the test method of the present invention refers to a gene ORF, a region that controls gene expression (for example, a promoter region, an enhancer region, etc.), a gene intron, or a linkage disequilibrium with these genes. It can exist in the area before and after that. Examples of polymorphisms include single nucleotide polymorphisms, polymorphisms in which one to several tens of bases (sometimes several thousand bases) are substituted, deleted, inserted, transferred, or inverted. There is no particular limitation. Further, the number of polymorphic sites is not limited to one and may be plural.
　本発明の検査方法において、多型部位の塩基の同定（すなわち、塩基種の決定）は、下記の方法によって行うことができる。
・抽出したゲノムDNA、転写産物、または多型領域を含むPCR で増幅したDNAを鋳型にして遺伝子配列を直接決定する方法。
・多型配列が制限酵素認識部位である場合、制限酵素切断パターンの相違を利用して、遺伝子型を決定する方法。
・多型領域に相補するプライマーの親和性が異なる結果、ポリメラーゼ塩基伸展反応の有無、あるいは程度を検出する方法。
・多型領域におけるポリメラーゼ塩基伸展反応の結果得られたDNAの分子量あるいは質量を測定する方法。
・多型部分に特異的なプローブを用いたハイブリダイゼーションの強度を比較する方法。
・多型領域における鋳型特異的なプライマーから開始されるポリメラーゼ塩基伸長反応の際、多型部位に取り込まれる塩基を特定する方法。
・鋳型特異的なプライマーに続いて多型領域に相補的な塩基対または非相補 
的な塩基対の有無を酵素によって認識させる方法。
　以上は代表的なＳＮＰ検出方法であるが、本発明の正常眼圧緑内障の検査においては、これらの方法に限定されるわけではない。 In the inspection method of the present invention, identification of the base at the polymorphic site (that is, determination of the base type) can be performed by the following method.
A method for directly determining gene sequences using extracted genomic DNA, transcripts, or DNA amplified by PCR containing polymorphic regions as a template.
-A method for determining a genotype using a difference in restriction enzyme cleavage pattern when the polymorphic sequence is a restriction enzyme recognition site.
A method for detecting the presence or absence or extent of polymerase base extension reaction as a result of different affinity of primers complementary to the polymorphic region.
A method for measuring the molecular weight or mass of DNA obtained as a result of polymerase base extension reaction in the polymorphic region.
A method of comparing the intensity of hybridization using a probe specific for the polymorphic part.
A method for identifying a base incorporated into a polymorphic site during a polymerase base extension reaction initiated from a template-specific primer in the polymorphic region.
・ Base-pair or non-complementary complementary to polymorphic region following template-specific primer
To make the enzyme recognize the presence or absence of basic base pairs.
The above are typical SNP detection methods, but the normal-tension glaucoma examination of the present invention is not limited to these methods.
　多型部位の塩基を同定するために、被検者の生体試料からゲノムＤＮＡを抽出するとよい。生体試料は、例えば、被検者の血液、皮膚、口腔粘膜、手術により採取あるいは切除した組織または細胞、検査等の目的で採取された体液（唾液、リンパ液、気道粘膜、精液、汗、尿など）等である。生体試料としては、末梢血から分離した白血球又は単核球が好ましい。市販のDNA抽出キットを用いて、生体試料からゲノムＤＮＡを抽出することができる。次いで、必要に応じて、多型部位を含むDNAを単離する。該DNAの単離は、多型部位を含むDNAにハイブリダイズすることができるプライマーを用いて、ゲノムDNA、あるいはRNAを鋳型としたPCR等によって行うことができる。 In order to identify the base of the polymorphic site, genomic DNA may be extracted from the subject's biological sample. Biological samples include, for example, the subject's blood, skin, oral mucosa, tissues or cells collected or excised by surgery, body fluids collected for the purpose of examination (saliva, lymph, airway mucosa, semen, sweat, urine, etc.) ) Etc. As the biological sample, leukocytes or mononuclear cells separated from peripheral blood are preferable. Genomic DNA can be extracted from a biological sample using a commercially available DNA extraction kit. Then, if necessary, DNA containing the polymorphic site is isolated. The DNA can be isolated by PCR or the like using genomic DNA or RNA as a template, using a primer capable of hybridizing to DNA containing a polymorphic site.
　また、本発明は、正常眼圧緑内障の検査をするための試薬であって、下記の(a)及び(b)の成分からなる群より選択される少なくとも１つの成分を含む前記試薬を提供する。 The present invention also provides a reagent for examining normal-tension glaucoma, which comprises at least one component selected from the group consisting of the following components (a) and (b): .
 (a) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域を増幅することができるプライマー (a) 領域 Region of human chromosome 6 containing ELOVL5, region of human chromosome 2 containing SRBD1, region of human chromosome 3 containing ARPP-21, region of human chromosome 4 containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 and And / or FLJ14126 region, human chromosome 3 THRB region, human chromosome 3 MED12L and / or CLRN10S and / or GPR171 region, human chromosome 4 SORBS2 region, human chromosome 5 A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6 .3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human 8 Region containing TNKS of chromosome, region containing ANGPT1 of human chromosome 8, region containing PGM5 of human chromosome 9, region containing TMC1 of human chromosome 9, region containing ROR2 of human chromosome 9, human 9 Region containing PPP6C and / or C9orf126 of chromosome, GRI of human chromosome 10 A region containing D1, a region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, Region containing MS4A7 and / or MS4A14 of chromosome 11, region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 , A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, and a region containing CA10 of human chromosome 17 A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, an APIP of human chromosome 11 and / or Region containing PDHX, human Primer capable of amplifying a region containing at least one polymorphic site in at least one region selected from the group consisting of a region containing CUX2 of chromosome 12 and a region containing TOM1L1 of human chromosome 17
(b) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域にハイブリダイズすることができるプローブ (b) A region of human chromosome 6 containing ELOVL5, a region of human chromosome 2 containing SRBD1, a region of human chromosome 3 containing ARPP-21, a region of human chromosome 4 containing EPHA5, a human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 and A region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6. 3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human chromosome 8 TNKS-containing region, human chromosome 8 ANGPT1 region, human chromosome 9 PGM5 region, human chromosome 9 TMC1 region, human chromosome 9 ROR2 region, human chromosome 9 A region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, A region containing chromosomal MS4A7 and / or MS4A14, a region containing human chromosome 11 MAP6 and / or GDPD5 and / or SERPINH1, a region containing human chromosome 11 11q23-24 (including PCSK7 and / or RNF214) A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, a region containing CA10 of human chromosome 17; A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11 Region containing, human Region including the CUX2 of 12 chromosomes, and probes that can hybridize to a region comprising at least one polymorphic sites in at least one region selected from the group consisting of a region including a TOM1L1 human chromosome 17
　ヒト第６染色体のELOVL5を含む領域における多型部位、ヒト第２染色体のSRBD1を含む領域における多型部位、ヒト第３染色体のARPP-21を含む領域における多型部位、ヒト第４染色体のEPHA5を含む領域における多型部位、ヒト第６染色体のGMDSを含む領域における多型部位、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位、ヒト第６染色体のSYTL3を含む領域における多型部位、ヒト第７染色体のNXPH1を含む領域における多型部位、ヒト第７染色体のLHFPL3を含む領域における多型部位、ヒト第１１染色体のGLB1L3を含む領域における多型部位、ヒト第１８染色体のZNF407を含む領域における多型部位、ヒト第１染色体のPAX7を含む領域における多型部位、ヒト第１染色体のPTPRFを含む領域における多型部位、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位、ヒト第１染色体のPKP1を含む領域における多型部位、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位、ヒト第３染色体のTHRBを含む領域における多型部位、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位、ヒト第４染色体のSORBS2を含む領域における多型部位、ヒト第５染色体のMAST4を含む領域における多型部位、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位、ヒト第５染色体のEBF1を含む領域における多型部位、ヒト第５染色体のDOCK2を含む領域における多型部位、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位、ヒト第６染色体のLOC100132919を含む領域における多型部位、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位、ヒト第７染色体のELMO1を含む領域における多型部位、ヒト第８染色体のTNKSを含む領域における多型部位、ヒト第８染色体のANGPT1を含む領域における多型部位、ヒト第９染色体のPGM5を含む領域における多型部位、ヒト第９染色体のTMC1を含む領域における多型部位、ヒト第９染色体のROR2を含む領域における多型部位、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位、ヒト第１０染色体のGRID1を含む領域における多型部位、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位、ヒト第１１染色体のOR5R1を含む領域における多型部位、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域における多型部位、ヒト第１２染色体のTAOK3を含む領域における多型部位、ヒト第１２染色体のSTX2を含む領域における多型部位、ヒト第１３染色体のCARS2を含む領域における多型部位、ヒト第１５染色体のCYP19A1を含む領域における多型部位、ヒト第１７染色体のCA10を含む領域における多型部位、ヒト第１８染色体のLOC643542を含む領域における多型部位、ヒト第２０染色体のPTPRTを含む領域における多型部位、ヒト第２１染色体のITSN1を含む領域における多型部位、ヒト第２染色体のLRP2を含む領域における多型部位、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位、ヒト第１２染色体のCUX2を含む領域における多型部位、ヒト第１７染色体のTOM1L1を含む領域における多型部位としては、上記のものを例示することができる。 Polymorphic site in human chromosome 6 containing ELOVL5, polymorphic site in human chromosome 2 containing SRBD1, polymorphic site in human chromosome 3 containing ARPP-21, human chromosome 4 EPHA5 The polymorphic site in the region containing GMDS, the polymorphic site in the region containing GMDS of human chromosome 6, the polymorphic site in the region containing 6p21.3 of human chromosome 6 (including HSPA1B), and SYTL3 of human chromosome 6 A polymorphic site in a region containing NXPH1 of human chromosome 7, a polymorphic site in a region containing LHFPL3 of human chromosome 7, a polymorphic site in a region containing GLB1L3 of human chromosome 11, human Polymorphic site in the region containing ZNF407 of chromosome 18, polymorphic site in the region containing PAX7 of human chromosome 1, polymorphic site in the region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1. 1 (CHD1L And / or FMO5), a polymorphic site in the region containing human chromosome 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), A polymorphic site in a region containing FAM5B and / or ASTN1 on chromosome 1, a polymorphic site in a region containing PKP1 on human chromosome 1, a polymorphic site in a region containing KLHL29 and / or FLJ14126 on human chromosome 2, Polymorphic site in the region containing THRB of chromosome 3, polymorphic site in region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, polymorphic site in region containing SORBS2 of human chromosome 4, human Polymorphic site in the region containing MAST4 on chromosome 5, polymorphic site in region containing GLRX and / or C5orf27 on human chromosome 5, polymorphic site in region containing EBF1 on human chromosome 5, DOCK2 on human chromosome 5 In the area containing Polymorphic site in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6, polymorphic site in the region containing LOC100132919 of human chromosome 6, human chromosome 7 Contains a polymorphic site in the region containing AAA1 and / or NPSR1 of A, a polymorphic site in a region containing ELMO1 of human chromosome 7, a polymorphic site in a region containing TNKS of human chromosome 8, and ANGPT1 of human chromosome 8 Polymorphic site in the region, polymorphic site in the region containing human chromosome 9 PGM5, polymorphic site in the region containing human chromosome 9 TMC1, polymorphic site in the region containing human chromosome 9 ROR2, Polymorphic site in the region containing PPP6C and / or C9orf126 of chromosome 9; polymorphic site in the region containing GRID1 of human chromosome 10; 11p11.2 of human chromosome 11 (SPI1 and / or SLC39A13 and / or PSMC3 and / or Or RAPSN and / or N Polymorphic site in the region containing UP160), polymorphic site in the region containing OR5R1 of human chromosome 11, polymorphic site in the region containing MS4A7 and / or MS4A14 of human chromosome 11, MAP6 of human chromosome 11 And / or a polymorphic site in a region containing GDPD5 and / or SERPINH1, a polymorphic site in a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), a region containing TAOK3 of human chromosome 12 A polymorphic site in the region containing STX2 of human chromosome 12, a polymorphic site in the region containing CARS2 of human chromosome 13, a polymorphic site in the region containing CYP19A1 of human chromosome 15, Polymorphic site in the region containing CA10 of the chromosome, polymorphic site in the region containing LOC643542 of human chromosome 18, polymorphic site in the region containing PTPRT of human chromosome 20, human 21st stain The polymorphic site in the region containing ITSN1 of the body, the polymorphic site in the region containing LRP2 of human chromosome 2, the polymorphic site in the region containing APIP and / or PDHX of human chromosome 11, and CUX2 of human chromosome 12 Examples of the polymorphic site in the containing region and the polymorphic site in the region containing TOM1L1 of human chromosome 17 can include those described above.
　さらにまた、本発明は、上記の試薬を含む、正常眼圧緑内障の検査キットを提供する。 Furthermore, the present invention provides a test kit for normal-tension glaucoma containing the above reagent.
　上記のプライマー及びプローブは、少なくとも15ヌクレオチドの鎖長を有するオリゴヌクレオチドであるとよい。該オリゴヌクレオチドをプライマーとして用いる場合、その長さは、通常15bp～100bpであり、好ましくは17bp～30bpである。プライマーは、上記多型部位を含むDNAの少なくとも一部を増幅しうるものであれば、特に制限されない。プライマーが増幅することができるDNAの長さは、通常、１５～１０００ｂｐ、好ましくは、２０～５００ｂｐ、より好ましくは２０～２００ｂｐである。また、該オリゴヌクレオチドをプローブとして用いる場合、その長さは、通常15bp～500bpであり、好ましくは30bp～500bpである。プローブは、上記多型部位を含むDNAとハイブリダイズしうるものであれば、特に制限されない。プローブがハイブリダイズできるＤＮＡの長さは、通常、１６～５００ｂｐ、好ましくは、２０～２００ｂｐ、より好ましくは２０～５０ｂｐである。 The above primers and probes may be oligonucleotides having a chain length of at least 15 nucleotides. When the oligonucleotide is used as a primer, its length is usually 15 to 100 bp, preferably 17 to 30 bp. The primer is not particularly limited as long as it can amplify at least a part of the DNA containing the polymorphic site. The length of DNA that can be amplified by the primer is usually 15 to 1000 bp, preferably 20 to 500 bp, more preferably 20 to 200 bp. When the oligonucleotide is used as a probe, the length is usually 15 bp to 500 bp, preferably 30 bp to 500 bp. The probe is not particularly limited as long as it can hybridize with the DNA containing the polymorphic site. The length of DNA to which the probe can hybridize is usually 16 to 500 bp, preferably 20 to 200 bp, more preferably 20 to 50 bp.
　本発明において、多型部位を含む領域を増幅することができるプライマーは、多型部位を含むDNAを鋳型として、多型部位に向かって相補鎖合成を開始することができるものであるとよい。 In the present invention, a primer capable of amplifying a region containing a polymorphic site is preferably one that can initiate complementary strand synthesis toward the polymorphic site using a DNA containing the polymorphic site as a template.
　プライマーには、多型部位を含む領域の塩基配列に相補的な塩基配列に加え、任意の塩基配列を付加することができる。例えば、IIs型の制限酵素を利用した多型の解析方法のためのプライマーにおいては、IIs型制限酵素の認識配列を付加したプライマーが利用される。更に、プライマーは修飾してもよい。例えば、蛍光物質や、ビオチンまたはジゴキシンのような結合親和性物質で標識したプライマーを利用してもよい。 In addition to the base sequence complementary to the base sequence of the region containing the polymorphic site, an arbitrary base sequence can be added to the primer. For example, in a primer for a polymorphism analysis method using a type IIs restriction enzyme, a primer to which a recognition sequence for a type IIs restriction enzyme is added is used. Furthermore, the primer may be modified. For example, a primer labeled with a fluorescent substance or a binding affinity substance such as biotin or digoxin may be used.
　本発明において、多型部位を含む領域にハイブリダイズすることができるプローブは、多型部位を含む領域の塩基配列を有するポリヌクレオチドとハイブリダイズすることができるものであればよく、多型部位を含む領域の塩基配列を有するDNAに特異的にハイブリダイズするものが好ましい。ここで「特異的にハイブリダイズする」とは、通常のハイブリダイゼーション条件下、好ましくはストリンジェントなハイブリダイゼーション条件下（例えば、サムブルックら,Molecular Cloning,Cold Spring Harbour Laboratory Press,New York,USA,第２版1989に記載の条件）において、多型部位を含む領域の塩基配列を有するDNA以外のDNAとクロスハイブリダイゼーションを有意に生じないことを意味する。より具体的には、プローブの塩基配列中に多型部位を含むプローブが好ましい。あるいは、多型部位における塩基の解析方法によっては、プローブの末端が多型部位に隣接する塩基に対応するように、デザインされる場合もある。従って、プローブ自身の塩基配列には多型部位が含まれないが、多型部位に隣接する領域に相補的な塩基配列を含むプローブも、本発明における望ましいプローブとして示すことができる。 In the present invention, the probe that can hybridize to the region containing the polymorphic site may be any probe that can hybridize to the polynucleotide having the base sequence of the region containing the polymorphic site. Those that specifically hybridize to DNA having the base sequence of the region to be included are preferred. Here, “specifically hybridizes” means normal hybridization conditions, preferably stringent hybridization conditions (for example, Sambrook et al., Molecular® Cloning, Cold® Spring® Harbor® Laboratory® Press, New® York, USA, In the condition described in the second edition 1989), it means that cross-hybridization does not occur significantly with DNA other than DNA having the base sequence of the region containing the polymorphic site. More specifically, a probe containing a polymorphic site in the base sequence of the probe is preferable. Alternatively, depending on the base analysis method at the polymorphic site, the probe may be designed so that the end of the probe corresponds to a base adjacent to the polymorphic site. Therefore, although the polymorphic site is not included in the base sequence of the probe itself, a probe including a base sequence complementary to the region adjacent to the polymorphic site can also be shown as a desirable probe in the present invention.
　プローブには、プライマーと同様に、塩基配列の改変、塩基配列の付加、あるいは修飾が許される。例えば、Invader法に用いるプローブは、フラップを構成するゲノムとは無関係な塩基配列が付加される。このようなプローブも、多型部位を含む領域にハイブリダイズする限り、本発明のプローブに含まれる。本発明のプローブを構成する塩基配列は、ゲノムにおける本発明の多型部位の周辺DNA領域の塩基配列をもとに、解析方法に応じてデザインすることができる。 The probe is allowed to modify the base sequence, add the base sequence, or modify the base sequence in the same manner as the primer. For example, a probe used for the Invader method is added with a base sequence unrelated to the genome constituting the flap. Such a probe is also included in the probe of the present invention as long as it hybridizes to a region containing a polymorphic site. The base sequence constituting the probe of the present invention can be designed according to the analysis method based on the base sequence of the DNA region surrounding the polymorphic site of the present invention in the genome.
　当業者であれば、多型部位を含む周辺DNA領域についての塩基配列情報を基に、解析手法に応じたプライマー及びプローブをデザインすることができる。プライマー及びプローブを構成する塩基配列は、ゲノムの塩基配列に対して完全に相補的な塩基配列のみならず、適宜改変することができる。 Those skilled in the art can design primers and probes according to the analysis method based on the base sequence information about the surrounding DNA region including the polymorphic site. The base sequences constituting the primers and probes can be modified as appropriate as well as the base sequences that are completely complementary to the genomic base sequences.
　プライマー及びプローブは、それを構成する塩基配列をもとに、任意の方法によって合成することができる。与えられた塩基配列に基づいて、当該塩基配列を有するオリゴヌクレオチドを合成する手法は公知である。更に、オリゴヌクレオチドの合成において、蛍光色素やビオチンなどで修飾されたヌクレオチド誘導体を利用して、オリゴヌクレオチドに任意の修飾を導入することもできる。あるいは、合成されたオリゴヌクレオチドに、蛍光色素などを結合する方法も公知である。 Primers and probes can be synthesized by any method based on the base sequences constituting them. A technique for synthesizing an oligonucleotide having the base sequence based on the given base sequence is known. Furthermore, in the synthesis of the oligonucleotide, any modification can be introduced into the oligonucleotide using a nucleotide derivative modified with a fluorescent dye or biotin. Alternatively, a method of binding a fluorescent dye or the like to a synthesized oligonucleotide is also known.
　プローブは、固相に固定されていてもよい（ＤＮＡアレイ）。DNAアレイは、同一平面上に配置した多数のプローブに対してサンプルDNA（あるいはRNA）をハイブリダイズさせ、当該平面をスキャンすることによって、各プローブに対するハイブリダイズが検出される。多くのプローブに対する反応を同時に観察することができることから、例えば、多数の多型部位について同時に解析するには、DNAアレイは有用である。ヌクレオチドの固定（アレイ）方法として、Affymetrix社開発によるオリゴヌクレオチドを基本としたアレイが例示できる。オリゴヌクレオチドのアレイにおいて、オリゴヌクレオチドは通常in situで合成される。例えば、リソグラフィー方式（Affymetrix社）、インクジェット方式(Agilent社)、ビーズアレイ方式(Illumina社)等によるオリゴヌクレオチドのin situ合成法が知られている。 The probe may be fixed on a solid phase (DNA array). In the DNA array, sample DNA (or RNA) is hybridized to a large number of probes arranged on the same plane, and the hybridization to each probe is detected by scanning the plane. Since responses to many probes can be observed simultaneously, for example, a DNA array is useful for analyzing a large number of polymorphic sites simultaneously. Examples of nucleotide immobilization (array) methods include arrays based on oligonucleotides developed by Affymetrix. In an array of oligonucleotides, the oligonucleotides are usually synthesized in situ. For example, in-situ synthesis methods of oligonucleotides by lithography method (Affymetrix), inkjet method (Agilent), bead array method (Illumina), etc. are known.
　オリゴヌクレオチドは、検出すべき多型部位を含む領域に相補的な塩基配列で構成される。基板に結合させるヌクレオチドプローブの長さは、オリゴヌクレオチドを固定する場合は、通常10～100ｂｐであり、好ましくは10～50ｂｐであり、さらに好ましくは15～25ｂｐである。 Oligonucleotide is composed of a base sequence complementary to a region containing a polymorphic site to be detected. The length of the nucleotide probe to be bound to the substrate is usually 10 to 100 bp, preferably 10 to 50 bp, more preferably 15 to 25 bp when the oligonucleotide is immobilized.
　DNAアレイ法によるSNP検出のための試料は、被検者から採取された生体試料をもとに当業者に周知の方法で調製することができる。生体試料は特に限定されない。例えば被検者の末梢血白血球、皮膚、口腔粘膜等の組織または細胞、涙、唾液、尿、糞便または毛髪から抽出したゲノムDNAから、DNA試料を調製することができる。判定すべき多型部位を含む領域を増幅するためのプライマーを用いて、ゲノムDNAの特定の領域が増幅される。このとき、マルチプレックスPCR法によって複数の領域を同時に増幅することができる。マルチプレックスPCR法とは、複数組のプライマーセットを、同じ反応液中で用いるPCR法である。複数の多型部位を解析するときには、マルチプレックスPCR法が有用である。 A sample for SNP detection by the DNA array method can be prepared by a method well known to those skilled in the art based on a biological sample collected from a subject. The biological sample is not particularly limited. For example, a DNA sample can be prepared from genomic DNA extracted from tissues or cells of peripheral blood leukocytes, skin, oral mucosa, etc., tears, saliva, urine, feces or hair of the subject. A specific region of genomic DNA is amplified using a primer for amplifying a region containing a polymorphic site to be determined. At this time, a plurality of regions can be simultaneously amplified by the multiplex PCR method. The multiplex PCR method is a PCR method using a plurality of primer sets in the same reaction solution. When analyzing multiple polymorphic sites, the multiplex PCR method is useful.
　一般にDNAアレイ法においては、PCR法によってDNA試料を増幅するとともに、増幅産物が標識される。増幅産物の標識には、標識を付したプライマーが利用される。例えば、まず多型部位を含む領域に特異的なプライマーセットによるPCR法でゲノムDNAを増幅する。次に、ビオチンラベルしたプライマーを使ったラベリングPCR法によって、ビオチンラベルされたDNAを合成する。こうして合成されたビオチンラベルDNAを、チップ上のオリゴヌクレオチドプローブにハイブリダイズさせる。ハイブリダイゼーションの反応液および反応条件は、固相に固定するヌクレオチドプローブの長さや反応温度等の条件に応じて、適宜調整することができる。当業者は、適切なハイブリダイゼーションの条件をデザインすることができる。ハイブリダイズしたDNAを検出するために、蛍光色素で標識したアビジンが添加される。アレイをスキャナで解析し、蛍光を指標としてハイブリダイズの有無を確認する。 In general, in the DNA array method, a DNA sample is amplified by the PCR method and the amplified product is labeled. A labeled primer is used for labeling the amplification product. For example, genomic DNA is first amplified by PCR using a primer set specific to the region containing the polymorphic site. Next, biotin-labeled DNA is synthesized by a labeling PCR method using a biotin-labeled primer. The biotin-labeled DNA synthesized in this way is hybridized to the oligonucleotide probe on the chip. The hybridization reaction solution and reaction conditions can be appropriately adjusted according to conditions such as the length of the nucleotide probe immobilized on the solid phase and the reaction temperature. One skilled in the art can design appropriate hybridization conditions. In order to detect the hybridized DNA, avidin labeled with a fluorescent dye is added. The array is analyzed with a scanner, and the presence or absence of hybridization is confirmed using fluorescence as an index.
　ＤＮＡアレイ法を用いて本発明の検査方法を実施する手順の一例を示せば、被検者から調製した多型部位を含むDNA及びヌクレオチドプローブが固定された固相を用意した後、該DNAと該固相を接触させる。次いで、固相に固定されたヌクレオチドプローブにハイブリダイズしたDNAを検出することにより、多型部位の塩基種を決定する。 An example of a procedure for carrying out the test method of the present invention using the DNA array method is as follows. After preparing a solid phase on which a DNA and nucleotide probe containing a polymorphic site prepared from a subject are immobilized, The solid phase is contacted. Subsequently, the base species of the polymorphic site is determined by detecting DNA hybridized to the nucleotide probe immobilized on the solid phase.
　本明細書において「固相」とは、ヌクレオチドを固定することが可能な材料を意味する。固相は、ヌクレオチドを固定することが可能であれば特に制限はないが、具体的には、マイクロプレートウェル、プラスチックビーズ、磁性粒子、基板などを含む固相等を例示することができる。固相としては、一般にDNAアレイ技術で使用される基板を好適に用いることができる。本明細書において「基板」とは、ヌクレオチドを固定することが可能な板状の材料を意味する。また、本発明においてヌクレオチドには、オリゴヌクレオチドおよびポリヌクレオチドが含まれる。 In this specification, “solid phase” means a material capable of immobilizing nucleotides. The solid phase is not particularly limited as long as nucleotides can be immobilized, and specific examples include a solid phase containing microplate wells, plastic beads, magnetic particles, a substrate, and the like. As the solid phase, a substrate generally used in DNA array technology can be preferably used. In the present specification, the “substrate” means a plate-like material capable of fixing nucleotides. In the present invention, the nucleotide includes oligonucleotides and polynucleotides.
　上記の方法以外にも、特定部位の塩基を検出するために、アレル特異的オリゴヌクレオチド（Allele Specific Oligonucleotide／ASO）ハイブリダイゼーション法が利用できる。アレル特異的オリゴヌクレオチド(ASO)は、検出すべき多型部位が存在する領域にハイブリダイズする塩基配列で構成される。ASOを試料DNAにハイブリダイズさせるとき、多型によって多型部位にミスマッチが生じるとハイブリッド形成の効率が低下する。ミスマッチは、サザンブロット法や、特殊な蛍光試薬がハイブリッドのギャップにインターカレーションすることにより消光する性質を利用した方法等によって検出することができる。また、リボヌクレアーゼAミスマッチ切断法によって、ミスマッチを検出することもできる。 In addition to the above method, an allele-specific oligonucleotide (Aligonucleotide / ASO) hybridization method can be used to detect a base at a specific site. An allele-specific oligonucleotide (ASO) is composed of a base sequence that hybridizes to a region where a polymorphic site to be detected exists. When ASO is hybridized to sample DNA, the hybridization efficiency decreases if a mismatch occurs at the polymorphic site due to the polymorphism. Mismatches can be detected by Southern blotting or a method that uses the property of quenching by intercalating a special fluorescent reagent into the hybrid gap. Mismatches can also be detected by the ribonuclease A mismatch cleavage method.
　本発明の試薬およびキットには、塩基の同定方法に応じて、各種の酵素、酵素基質、および緩衝液などを含めることができる。酵素としては、DNAポリメラーゼ、DNAリガーゼ、あるいはIIs制限酵素などの、上記の塩基同定方法として例示した各種の解析方法に必要な酵素を示すことができる。緩衝液は、これらの解析に用いる酵素の活性の維持に好適な緩衝液が、適宜選択される。更に、酵素基質としては、例えば、相補鎖合成用の基質等が用いられる。 The reagents and kits of the present invention can contain various enzymes, enzyme substrates, buffers, and the like depending on the base identification method. Examples of the enzyme include enzymes necessary for the various analysis methods exemplified as the base identification method, such as DNA polymerase, DNA ligase, or IIs restriction enzyme. As the buffer solution, a buffer solution suitable for maintaining the activity of the enzyme used for these analyzes is appropriately selected. Furthermore, as the enzyme substrate, for example, a substrate for complementary strand synthesis is used.
　さらに、本発明の試薬およびキットには、多型部位における塩基が明らかな対照を添付することができる。対照としては、予め多型部位の塩基種が明らかなゲノムDNA、あるいはゲノムDNAの断片を用いることができる。ゲノムDNAは、細胞から抽出されたものを対照として添付してもよいし、あるいは、細胞又は細胞の分画を対照として添付しておき、そこから使用者がゲノムDNAを抽出してもよい。細胞を対照として用いれば、対照の結果によってゲノムDNAの抽出操作が正しく行われたことを証明することができる。あるいは、多型部位を含む塩基配列からなるDNAを対照として用いることもできる。具体的には、多型部位における塩基種が明らかにされたゲノム由来のDNAを含むYACベクターやBACベクターを対照として用いてもよい。あるいは多型部位に相当する数十から数百ｂｐのみを切り出して挿入したベクターを対照として用いることもできる。 Furthermore, a control in which the base at the polymorphic site is clear can be attached to the reagent and kit of the present invention. As a control, genomic DNA or a fragment of genomic DNA in which the base type of the polymorphic site is known in advance can be used. Genomic DNA extracted from cells may be attached as a control, or a cell or a fraction of cells may be attached as a control, and a user may extract genomic DNA therefrom. If a cell is used as a control, the result of the control can prove that the genomic DNA extraction operation was performed correctly. Alternatively, DNA comprising a base sequence containing a polymorphic site can be used as a control. Specifically, a YAC vector or a BAC vector containing a genome-derived DNA whose base type at the polymorphic site has been clarified may be used as a control. Alternatively, a vector in which only tens to hundreds of bp corresponding to the polymorphic site are excised and inserted can be used as a control.
　また、本発明は、ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む最長１０００塩基長の連続したＤＮＡ部分配列又はその相補鎖からなるポリヌクレオチドを含む正常眼圧緑内障診断用マーカー遺伝子を提供する。 The present invention also includes a region containing ELOVL5 of human chromosome 6, a region containing SRBD1 of human chromosome 2, a region containing ARPP-21 of human chromosome 3, a region containing EPHA5 of human chromosome 4, The region containing 6 chromosomes of GMDS, the region containing human chromosome 6p21.3 (including HSPA1B), the region containing human chromosome 6 SYTL3, the region containing human chromosome 7 NXPH1, the region of human chromosome 7 A region containing LHFPL3, a region containing GLB1L3 of human chromosome 11, a region containing ZNF407 of human chromosome 18, a region containing PAX7 of human chromosome 1, a region containing PTPRF of human chromosome 1, Region containing 1q12-q21.1 (including CHD1L and / or FMO5), region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1, human first Region containing FAM5B and / or ASTN1 of chromosome, region containing PKP1 of human chromosome 1, human second A region containing KLHL29 and / or FLJ14126 of the chromophore, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4. A region containing MAST4 of human chromosome 5, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21 of human chromosome 6 .31-p21.3 (including HLA-DPA1), human chromosome 6 LOC100132919 region, human chromosome 7 AAA1 and / or NPSR1 region, human chromosome 7 ELMO1 region , A region containing TNKS of human chromosome 8, a region containing ANGPT1 of human chromosome 8, a region containing PGM5 of human chromosome 9, a region containing TMC1 of human chromosome 9, a region containing ROR2 of human chromosome 9 A region of human chromosome 9 containing PPP6C and / or C9orf126, human chromosome 9 Region containing GRID1 of chromosome 0, region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), region containing OR5R1 of human chromosome 11 A region containing MS4A7 and / or MS4A14 of human chromosome 11, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214) A region containing TAOK3 of human chromosome 12, a region containing STX2 of human chromosome 12, a region containing CARS2 of human chromosome 13, a region containing CYP19A1 of human chromosome 15, CA10 of human chromosome 17 A region containing LOC643542 of human chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP of human chromosome 11 And / or PDHX A region containing at least one polymorphic site in at least one region selected from the group consisting of a region comprising CUX2 of human chromosome 12 and a region comprising TOM1L1 of human chromosome 17. Provided is a marker gene for normal tension glaucoma diagnosis comprising a polynucleotide comprising a continuous DNA partial sequence or its complementary strand.
　ヒト第６染色体のELOVL5を含む領域における多型部位、ヒト第２染色体のSRBD1を含む領域における多型部位、ヒト第３染色体のARPP-21を含む領域における多型部位、ヒト第４染色体のEPHA5を含む領域における多型部位、ヒト第６染色体のGMDSを含む領域における多型部位、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位、ヒト第６染色体のSYTL3を含む領域における多型部位、ヒト第７染色体のNXPH1を含む領域における多型部位、ヒト第７染色体のLHFPL3を含む領域における多型部位、ヒト第１１染色体のGLB1L3を含む領域における多型部位、ヒト第１８染色体のZNF407を含む領域における多型部位、ヒト第１染色体のPAX7を含む領域における多型部位、ヒト第１染色体のPTPRFを含む領域における多型部位、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位、ヒト第１染色体のPKP1を含む領域における多型部位、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位、ヒト第３染色体のTHRBを含む領域における多型部位、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位、ヒト第４染色体のSORBS2を含む領域における多型部位、ヒト第５染色体のMAST4を含む領域における多型部位、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位、ヒト第５染色体のEBF1を含む領域における多型部位、ヒト第５染色体のDOCK2を含む領域における多型部位、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位、ヒト第６染色体のLOC100132919を含む領域における多型部位、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位、ヒト第７染色体のELMO1を含む領域における多型部位、ヒト第８染色体のTNKSを含む領域における多型部位、ヒト第８染色体のANGPT1を含む領域における多型部位、ヒト第９染色体のPGM5を含む領域における多型部位、ヒト第９染色体のTMC1を含む領域における多型部位、ヒト第９染色体のROR2を含む領域における多型部位、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位、ヒト第１０染色体のGRID1を含む領域における多型部位、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位、ヒト第１１染色体のOR5R1を含む領域における多型部位、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域における多型部位、ヒト第１２染色体のTAOK3を含む領域における多型部位、ヒト第１２染色体のSTX2を含む領域における多型部位、ヒト第１３染色体のCARS2を含む領域における多型部位、ヒト第１５染色体のCYP19A1を含む領域における多型部位、ヒト第１７染色体のCA10を含む領域における多型部位、ヒト第１８染色体のLOC643542を含む領域における多型部位、ヒト第２０染色体のPTPRTを含む領域における多型部位、ヒト第２１染色体のITSN1を含む領域における多型部位、ヒト第２染色体のLRP2を含む領域における多型部位、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位、ヒト第１２染色体のCUX2を含む領域における多型部位、ヒト第１７染色体のTOM1L1を含む領域における多型部位としては、上記のものを例示することができる。 Polymorphic site in human chromosome 6 containing ELOVL5, polymorphic site in human chromosome 2 containing SRBD1, polymorphic site in human chromosome 3 containing ARPP-21, human chromosome 4 EPHA5 The polymorphic site in the region containing GMDS, the polymorphic site in the region containing GMDS of human chromosome 6, the polymorphic site in the region containing 6p21.3 of human chromosome 6 (including HSPA1B), and SYTL3 of human chromosome 6 A polymorphic site in a region containing NXPH1 of human chromosome 7, a polymorphic site in a region containing LHFPL3 of human chromosome 7, a polymorphic site in a region containing GLB1L3 of human chromosome 11, human Polymorphic site in the region containing ZNF407 of chromosome 18, polymorphic site in the region containing PAX7 of human chromosome 1, polymorphic site in the region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1. 1 (CHD1L And / or FMO5), a polymorphic site in the region containing human chromosome 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), A polymorphic site in a region containing FAM5B and / or ASTN1 on chromosome 1, a polymorphic site in a region containing PKP1 on human chromosome 1, a polymorphic site in a region containing KLHL29 and / or FLJ14126 on human chromosome 2, Polymorphic site in the region containing THRB of chromosome 3, polymorphic site in region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, polymorphic site in region containing SORBS2 of human chromosome 4, human Polymorphic site in the region containing MAST4 on chromosome 5, polymorphic site in region containing GLRX and / or C5orf27 on human chromosome 5, polymorphic site in region containing EBF1 on human chromosome 5, DOCK2 on human chromosome 5 In the area containing Polymorphic site in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6, polymorphic site in the region containing LOC100132919 of human chromosome 6, human chromosome 7 Contains a polymorphic site in the region containing AAA1 and / or NPSR1 of A, a polymorphic site in a region containing ELMO1 of human chromosome 7, a polymorphic site in a region containing TNKS of human chromosome 8, and ANGPT1 of human chromosome 8 Polymorphic site in the region, polymorphic site in the region containing human chromosome 9 PGM5, polymorphic site in the region containing human chromosome 9 TMC1, polymorphic site in the region containing human chromosome 9 ROR2, Polymorphic site in the region containing PPP6C and / or C9orf126 of chromosome 9; polymorphic site in the region containing GRID1 of human chromosome 10; 11p11.2 of human chromosome 11 (SPI1 and / or SLC39A13 and / or PSMC3 and / or Or RAPSN and / or N Polymorphic site in the region containing UP160), polymorphic site in the region containing OR5R1 of human chromosome 11, polymorphic site in the region containing MS4A7 and / or MS4A14 of human chromosome 11, MAP6 of human chromosome 11 And / or a polymorphic site in a region containing GDPD5 and / or SERPINH1, a polymorphic site in a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), a region containing TAOK3 of human chromosome 12 A polymorphic site in the region containing STX2 of human chromosome 12, a polymorphic site in the region containing CARS2 of human chromosome 13, a polymorphic site in the region containing CYP19A1 of human chromosome 15, Polymorphic site in the region containing CA10 of the chromosome, polymorphic site in the region containing LOC643542 of human chromosome 18, polymorphic site in the region containing PTPRT of human chromosome 20, human 21st stain The polymorphic site in the region containing ITSN1 of the body, the polymorphic site in the region containing LRP2 of human chromosome 2, the polymorphic site in the region containing APIP and / or PDHX of human chromosome 11, and CUX2 of human chromosome 12 Examples of the polymorphic site in the containing region and the polymorphic site in the region containing TOM1L1 of human chromosome 17 can include those described above.
　本発明のマーカー遺伝子は、通常、１０塩基長以上、好ましくは２０塩基長以上の長さである。例えば、上記多型部位を含む５０塩基長、１００塩基長、２００塩基長、３００塩基長、６００塩基長、１０００塩基長などの長さでありうる。本発明のマーカー遺伝子の全長塩基配列を決定することにより、その遺伝子のORF、その遺伝子の発現を制御する領域（例えば、プロモーター領域、エンハンサー領域等）などを決定することができる。さらには、ORFがコードするポリペプチドのアミノ酸配列を決定することができる。上記遺伝子領域やポリペプチドは、正常眼圧緑内障の病因又は発症機序に関与している可能性が高いため、それらの機能を促進又は阻害することにより、正常眼圧緑内障を予防及び/又は治療できる可能性がある。 The marker gene of the present invention is usually 10 bases or longer, preferably 20 bases or longer. For example, it may be 50 base length, 100 base length, 200 base length, 300 base length, 600 base length, 1000 base length or the like including the polymorphic site. By determining the full-length base sequence of the marker gene of the present invention, the ORF of the gene, the region controlling the expression of the gene (for example, promoter region, enhancer region, etc.) can be determined. Furthermore, the amino acid sequence of the polypeptide encoded by ORF can be determined. Since the above gene regions and polypeptides are likely to be involved in the pathogenesis or pathogenesis of normal-tension glaucoma, by preventing or / or treating normal-tension glaucoma by promoting or inhibiting their function There is a possibility.
　本発明のマーカー遺伝子のDNA配列がコードするポリペプチドは、該DNA配列（少なくとも翻訳領域を含有するその断片でもよい）を含有するベクターで形質転換した宿主細胞を培養し、培養物から該ポリペプチドを採取することにより製造することができる。本発明は、本発明のマーカー遺伝子のＤＮＡ配列を含有するベクター、該ベクターで形質転換した宿主細胞も提供するものである。 The polypeptide encoded by the DNA sequence of the marker gene of the present invention is obtained by culturing host cells transformed with a vector containing the DNA sequence (or at least a fragment thereof containing a translation region), and culturing the polypeptide from the culture. Can be produced. The present invention also provides a vector containing the DNA sequence of the marker gene of the present invention and a host cell transformed with the vector.
　本発明のマーカー遺伝子のDNA配列は、例えば、以下のようにして製造することができる。ヒト生体試料（例えば、健常者や患者の血液）からmRNAを抽出し、逆転写酵素およびオリゴdTプライマーを用いてcDNAを合成する。これを鋳型として、本発明のマーカー遺伝子をPCRによって増幅する。 The DNA sequence of the marker gene of the present invention can be produced, for example, as follows. MRNA is extracted from a human biological sample (for example, blood of a healthy person or a patient), and cDNA is synthesized using reverse transcriptase and oligo dT primer. Using this as a template, the marker gene of the present invention is amplified by PCR.
　本発明のマーカー遺伝子のDNA配列を含有するベクター（組換えベクター）は、公知の方法（例えば、Molecular Cloning２nd Edition, J. Sambrook et al., Cold Spring Harbor Lab. Press, 1989に記載の方法）により、本発明のマーカー遺伝子のDNA配列を適当な発現ベクターに挿入することにより得られる。 A vector (recombinant vector) containing the DNA sequence of the marker gene of the present invention can be obtained by a known method (for example, the method described in Molecular Cloning 2nd Edition, J. Sambrook et al., Cold Spring Harbor Lab. Press, 1989). It can be obtained by inserting the DNA sequence of the marker gene of the present invention into an appropriate expression vector.
　発現ベクターとしては、大腸菌由来のプラスミド（例、ｐＢＲ３２２，ｐＢＲ３２５，ｐＵＣ１２，ｐＵＣ１３）、枯草菌由来のプラスミド（例、ｐＵＢ１１０，ｐＴＰ５，ｐＣ１９４）、酵母由来プラスミド（例、ｐＳＨ１９，ｐＳＨ１５）、λファージなどのバクテリオファージ、レトロウイルス，ワクシニアウイルスなどの動物ウイルス、バキュロウイルスなどの昆虫病原ウイルスなどを用いることができる。 As expression vectors, plasmids derived from E. coli (eg, pBR322, pBR325, pUC12, pUC13), plasmids derived from Bacillus subtilis (eg, pUB110, pTP5, pC194), yeast-derived plasmids (eg, pSH19, pSH15), λ phage, etc. Bacteriophages, animal viruses such as retroviruses and vaccinia viruses, insect pathogenic viruses such as baculoviruses, and the like can be used.
　発現ベクターには、プロモーター、エンハンサー、スプライシングシグナル、ポリＡ付加シグナル、選択マーカー、SV40複製オリジンなどを付加してもよい。 A promoter, enhancer, splicing signal, poly A addition signal, selection marker, SV40 replication origin, etc. may be added to the expression vector.
　また、発現ベクターは、融合タンパク質発現ベクターであってもよい。種々の融合タンパク質発現ベクターが市販されており、pGEXシリーズ（アマシャムファルマシアバイオテク社）、pET CBD Fusion System 34b-38b（Novagen社）、pET Dsb Fusion Systems 39b and 40b（Novagen社）、pET GST Fusion System 41 and 42（Novagen社）などを例示することができる。 In addition, the expression vector may be a fusion protein expression vector. Various fusion protein expression vectors are commercially available: pGEX series (Amersham Pharmacia Biotech), pET CBD Fusion System 34b-38b (Novagen), pET Dsb Fusion Systems 39b and 40b (Novagen), pET GST Fusion System 41 and 42 (Novagen).
　本発明のマーカー遺伝子のDNA配列を含有するベクター（組換えベクター）を宿主細胞に導入することにより、形質転換体を得ることができる。 A transformant can be obtained by introducing a vector (recombinant vector) containing the DNA sequence of the marker gene of the present invention into a host cell.
　宿主細胞としては、細菌細胞（例えば、エシェリヒア属菌、バチルス属菌、枯草菌など）、真菌細胞（例えば、酵母、アスペルギルスなど）、昆虫細胞（例えば、S2細胞、Sf細胞など）、動物細胞（例えば、CHO細胞、COS細胞、HeLa細胞、C127細胞、3T3細胞、BHK細胞、HEK293細胞など）、植物細胞などを例示することができる。 Host cells include bacterial cells (eg, Escherichia, Bacillus, Bacillus, etc.), fungal cells (eg, yeast, Aspergillus, etc.), insect cells (eg, S2 cells, Sf cells, etc.), animal cells ( Examples thereof include CHO cells, COS cells, HeLa cells, C127 cells, 3T3 cells, BHK cells, HEK293 cells), plant cells, and the like.
　組換えベクターを宿主に導入するには、Molecular Cloning２nd Edition, J. Sambrook et al., Cold Spring Harbor Lab. Press, 1989に記載の方法（例えば、リン酸カルシウム法、DEAE-デキストラン法、トランスフェクション法、マイクロインジェクション法、リポフェクション法、エレクロトポレーション法、形質導入法、スクレープローディング法、ショットガン法など）または感染により行うことができる。 In order to introduce the recombinant vector into the host, the method described in Molecular® Cloning 2nd Edition, “J. Sambrook” et al., “Cold” Spring Harbor ”Lab.“ Press, ”1989 (for example, calcium phosphate method, DEAE-dextran method, transfection method, micro Injection method, lipofection method, electroporation method, transduction method, scrape loading method, shotgun method, etc.) or infection.
　形質転換体を培地で培養し、培養物からマーカー遺伝子のDNA配列がコードするポリペプチドを採取することができる。ポリペプチドが培地に分泌される場合には、培地を回収し、その培地からポリペプチドを分離し、精製すればよい。ポリペプチドが形質転換された宿主細胞内に産生される場合には、その細胞を溶解し、その溶解物からポリペプチドを分離し、精製すればよい。 The transformant can be cultured in a medium, and the polypeptide encoded by the DNA sequence of the marker gene can be collected from the culture. When the polypeptide is secreted into the medium, the medium may be recovered, the polypeptide separated from the medium, and purified. When the polypeptide is produced in a transformed host cell, the cell may be lysed, the polypeptide separated from the lysate and purified.
　ポリペプチドが別のタンパク質（タグとして機能する）との融合タンパク質の形態で発現される場合には、融合タンパク質を分離及び精製した後に、FactorXaや酵素（エンテロキナーゼ）処理をすることにより、別のタンパク質を切断し、目的とするポリペプチドを得ることができる。 When the polypeptide is expressed in the form of a fusion protein with another protein (functioning as a tag), the fusion protein is separated and purified, and then treated with FactorXa or an enzyme (enterokinase). The target polypeptide can be obtained by cleaving the protein.
　ポリペプチドの分離及び精製は、公知の方法により行うことができる。公知の分離、精製法としては、塩析や溶媒沈澱法などの溶解度の差を利用する方法、透析法、限外ろ過法、ゲルろ過法、およびＳＤＳ－ポリアクリルアミドゲル電気泳動法などの分子量の差を利用する方法、イオン交換クロマトグラフィーなどの荷電の差を利用する方法、アフィニティークロマトグラフィーなどの特異的親和性を利用する方法、逆相高速液体クロマトグラフィーなどの疎水性の差を利用する方法、等電点電気泳動法などの等電点の差を利用する方法などが用いられる。 Separation and purification of the polypeptide can be performed by known methods. Known separation and purification methods include methods that utilize differences in solubility such as salting out and solvent precipitation, dialysis, ultrafiltration, gel filtration, and SDS-polyacrylamide gel electrophoresis. Method utilizing difference, method utilizing charge difference such as ion exchange chromatography, method utilizing specific affinity such as affinity chromatography, method utilizing hydrophobic difference such as reverse phase high performance liquid chromatography A method using a difference in isoelectric point, such as isoelectric focusing, is used.
　以下、実施例に基づいて本発明を詳細に説明するが、本発明はこれらの実施例に限定されるものではない。 Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited to these examples.
〔実施例１〕
　NTGは多くの遺伝要因が多数重なることにより発症の危険度が増大する多因子疾患であると考えられている。NTGの疾患感受性遺伝子を同定し、それをもとに迅速遺伝子診断キットを開発することで、NTGの早期発見しいては早期診断に繋がることが期待される。現在までにNTGを含む緑内障の疾患感受性遺伝子としてMYOC遺伝子、OPA1遺伝子やOPTN遺伝子などが報告されているが、いずれも緑内障患者の数％にしか見られず、日本人においてはほとんど相関を示さない。したがって、本発明者は、NTGの疾患感受性遺伝子を網羅的に同定するため、Affymetrix社のGeneChip Mapping 500k Array setを用いて、50万以上のSNPをハイスループットに一度に解析を行うことで、全ゲノム領域を対象とした網羅的な遺伝子スクリーニングを行った。また、本研究の解析データは膨大な量になり、従来のデータベースでは扱えない容量であるため、大規模な量のSNPを用いた相関解析に対応するSNP解析用データベースの開発を行った。 [Example 1]
NTG is considered to be a multifactorial disease that increases the risk of onset due to a large number of many genetic factors. By identifying a disease susceptibility gene of NTG and developing a rapid genetic diagnosis kit based on it, it is expected that early detection of NTG will lead to early diagnosis. To date, MYOC, OPA1 and OPTN genes have been reported as susceptibility genes for glaucoma including NTG, but these are only found in a few percent of glaucoma patients and show little correlation in Japanese. . Therefore, in order to comprehensively identify the NTG disease susceptibility genes, the present inventor analyzed all 500,000 SNPs at a high throughput at a time using the GeneChip Mapping 500k Array set of Affymetrix. Exhaustive genetic screening for genomic regions was performed. In addition, because the analysis data of this study is enormous and cannot be handled by conventional databases, we developed a database for SNP analysis that supports correlation analysis using a large amount of SNP.
 (1)50万SNP解析用データベースの構築
　統計学的解析に用いるデータベースは従来のデータベースを大規模SNPタイピングに使用できるように改変・作成した。本発明者の研究室で現在SNP解析に使用しているデータベースはTaqman(登録商標)SNP Genotyping Assay用であり、統計計算とHardy-Weinberg検定が可能なものである。現在稼動中のデータベース管理システムに準じ、(i)Gene Chip 250kおよび500ｋのSNPタイピング出力ファイル（Textファイル）をデータベース入力用ファイルとしてデータ入力できること、(ii)GTYPEで使用されているSNP IDとrs番号・位置情報・近傍の遺伝子情報・人種別既知アリル情報（Hapmap）との対応が管理できること、(iii)Haploview他、各種解析ソフトの入力用テキストフォーマットを任意に指定して出力ファイルとして得られることなど、新しい機能を付加し、登録データや解析結果の検索・ソート・抽出表示が可能なデータベースの構築を行った。 (1) Construction of a database for 500,000 SNP analysis The database used for statistical analysis was modified and created so that a conventional database could be used for large-scale SNP typing. The database currently used for SNP analysis in the inventor's laboratory is for Taqman (registered trademark) SNP Genotyping Assay, and is capable of statistical calculation and Hardy-Weinberg test. According to the database management system currently in operation, (i) SNP typing output file (Text file) of Gene Chip 250k and 500k can be input as database input file, (ii) SNP ID and rs used in GTYPE It is possible to manage the correspondence with number, position information, neighboring gene information, and allele type known allele information (Hapmap), and (iii) Haploview and other input text formats for various analysis software can be arbitrarily specified and obtained as an output file A database that can search, sort, extract and display registered data and analysis results has been constructed.
 (2)500k GeneChipを用いた全ゲノム網羅的SNP解析
　横浜市立大学ほか共同研究医療機関において年齢、眼圧、屈折異常など厳密なクライテリアを満たしたNTG患者血液白血球を収集した。QIAamp DNA Blood Maxi Kitを用いてDNAを抽出した。DNAチップの解析方法はAffymetrix社のプロトコールに準拠して行った。疾患感受性遺伝子のスクリーニング法としてAffymetrix社GeneChipのHuman Mapping 500k Array setを用いたSNP解析を行った。Gene ChipのMapping 500k Array setは2枚の高密度オリゴヌクレオチドアレイ(250k Array)、NspIとStyIからなり、各アレイは平均25万SNPをジェノタイピングすることが可能である。Mapping 500k setの全てのSNPは厳密なスクリーニングと評価実験を受けている。1度の実験で50万以上のSNPのジェノタイピングを行えることから、全ゲノムの網羅的な解析ツールとして有用である。まず、PicoGreen定量キット(PicoGreen ds DNA Quantification Reagent and Kit 200-2000 assay)を用いてDNA濃度を定量し、各サンプルのDNA濃度が均一になるように調製した。その後、全ゲノムを制限酵素で切断し、4塩基の特異的突出端末を認識するアダプターをライゲーションした。アダプターを付加したDNA断片をPCRで増幅し、フラグメント化して標識した後、Mapping 250k Arrayにハイブリダイゼーションさせた。蛍光で染色し、レーザースキャナーで各プローブの蛍光強度から各SNPの対立遺伝子をDirect Model (DM) Algorithm（DMアルゴリズム）を用いて解析を行った。得られた結果からSNPごとに患者群と健常群の対立遺伝子分布を統計学的に解析し、疾患と相関する遺伝子の決定を行う。実験精度とコンタミネーションの評価はmodified partitioning aroundmethods (MPAM) algorithm（MPAMアルゴリズム）にて行った。
　NTG患者266検体についてAffymetrix社GeneChip(登録商標)mapping 500kアレイを用いたSNPタイピングを終了した。SNPのcall rate（解析が適切に行われたSNPの割合）はNspIとStyIの両アレイともに平均95％以上と良好なタイピング精度を示した。患者255検体、健常者187検体ずつを対象に統計解析を行った結果、16,562個のSNPがP値0.05未満の陽性を示した。これらのSNPについてジェノタイピングの精度の評価を行うとともに、遺伝子型のタイピングエラーおよび妥当性を評価するため、ハーディーワインバーグ検定を行い、統計解析不向きなSNPを除外したところ、最終的に15,729個のSNPがP値0.05未満を示した。疾患とより顕著な相関を示すP値0.00001未満では24個のSNPが陽性を示した。 (2) Genome-wide comprehensive SNP analysis using 500k GeneChip We collected blood leukocytes of NTG patients who met strict criteria such as age, intraocular pressure, refractive error, etc. at Yokohama City University and other joint research medical institutions. DNA was extracted using QIAamp DNA Blood Maxi Kit. The analysis method of the DNA chip was performed according to the protocol of Affymetrix. As a screening method for disease susceptibility genes, SNP analysis was performed using Affymetrix GeneChip's Human Mapping 500k Array set. Gene Chip's Mapping 500k Array set consists of two high-density oligonucleotide arrays (250k Array), NspI and StyI, each capable of genotyping an average of 250,000 SNPs. All SNPs in the Mapping 500k set have undergone rigorous screening and evaluation experiments. Since it can genotype more than 500,000 SNPs in a single experiment, it is useful as a comprehensive analysis tool for the entire genome. First, the DNA concentration was quantified using a PicoGreen quantification kit (PicoGreen ds DNA Quantification Reagent and Kit 200-2000 assay) to prepare a uniform DNA concentration for each sample. Thereafter, the whole genome was cleaved with a restriction enzyme, and an adapter recognizing a specific protruding terminal of 4 bases was ligated. The DNA fragment to which the adapter was added was amplified by PCR, fragmented and labeled, and then hybridized to Mapping 250k Array. After staining with fluorescence, the alleles of each SNP were analyzed from the fluorescence intensity of each probe with a laser scanner using the Direct Model (DM) Algorithm. Based on the obtained results, the allele distribution of the patient group and the healthy group is statistically analyzed for each SNP, and the genes that correlate with the disease are determined. Experimental accuracy and contamination were evaluated using modified partitioning aroundmethods (MPAM) algorithm.
SNP typing using Affymetrix GeneChip (registered trademark) mapping 500k array was completed for 266 NTG patients. The SNP call rate (the proportion of SNPs that were analyzed properly) averaged over 95% for both NspI and StyI arrays, indicating good typing accuracy. As a result of statistical analysis on 255 patients and 187 healthy subjects, 16,562 SNPs were positive with a P value of less than 0.05. In addition to evaluating the accuracy of genotyping for these SNPs, the Hardy-Weinberg test was performed to evaluate genotyping errors and validity, and SNPs unsuitable for statistical analysis were excluded. SNP showed P value less than 0.05. Twenty-four SNPs were positive at a P value of less than 0.00001 indicating a more pronounced correlation with the disease.
　これらの遺伝子の中で次の３つの条件を満たすものをさらに重要な正常眼圧緑内障の疾患感受性遺伝子とした。
１．HapMapデータベースと比較し、健常者のアリル頻度が妥当である。
２．近接するSNPも同様に疾患と相関している。
３．SNPは遺伝子上または遺伝子近傍に位置する。
　第６染色体のELOVL5領域を含む0.5Mbについて、この結果を表１及び図１に示す。 Among these genes, those satisfying the following three conditions were regarded as more important normal-tension glaucoma disease susceptibility genes.
1. Compared with the HapMap database, the allele frequency of healthy subjects is reasonable.
2. Adjacent SNPs are similarly correlated with disease.
3. SNPs are located on or near genes.
The results are shown in Table 1 and FIG. 1 for 0.5 Mb containing the ELOVL5 region of chromosome 6.
Figure JPOXMLDOC01-appb-T000001
 　第２染色体のSRBD1領域を含む0.5Mbについて、この結果を表２及び図２に示す。
Figure JPOXMLDOC01-appb-T000001
 The results are shown in Table 2 and FIG. 2 for 0.5 Mb containing the SRBD1 region of the second chromosome.
Figure JPOXMLDOC01-appb-T000002
 　第３染色体のARPP-21領域を含む500Kbについて、この結果を表３及び図３に示す。
Figure JPOXMLDOC01-appb-T000002
 The results are shown in Table 3 and FIG. 3 for 500 Kb containing the ARPP-21 region of chromosome 3.
Figure JPOXMLDOC01-appb-T000003
 　第４染色体のEPHA5領域を含む500Kbについて、この結果を表４及び図４に示す。
Figure JPOXMLDOC01-appb-T000003
 The results are shown in Table 4 and FIG. 4 for 500 Kb containing the EPHA5 region of chromosome 4.
Figure JPOXMLDOC01-appb-T000004
 　第６染色体のGMDS領域を含む1500Kbについて、この結果を表５及び図５に示す。
Figure JPOXMLDOC01-appb-T000004
 The results are shown in Table 5 and FIG. 5 for 1500 Kb including the GMDS region of chromosome 6.
Figure JPOXMLDOC01-appb-T000005
 　第６染色体の6p21.3（HSPA1Bを含む）領域を含む500Kbについて、この結果を表６及び図６に示す。
Figure JPOXMLDOC01-appb-T000005
 The results are shown in Table 6 and FIG. 6 for 500 Kb containing the 6p21.3 (including HSPA1B) region of chromosome 6.
Figure JPOXMLDOC01-appb-T000006
 　第６染色体のSYTL3領域を含む500Kbについて、この結果を表７及び図７に示す。
Figure JPOXMLDOC01-appb-T000006
 The results are shown in Table 7 and FIG. 7 for 500 Kb containing the SYTL3 region of chromosome 6.
Figure JPOXMLDOC01-appb-T000007
 　第７染色体のNXPH1領域を含む500Kbについて、この結果を表８及び図８に示す。
Figure JPOXMLDOC01-appb-T000007
 The results are shown in Table 8 and FIG. 8 for 500 Kb containing the NXPH1 region of chromosome 7.
Figure JPOXMLDOC01-appb-T000008
 　第７染色体のLHFPL3領域を含む500Kbについて、この結果を表９及び図９に示す。
Figure JPOXMLDOC01-appb-T000008
 The results are shown in Table 9 and FIG. 9 for 500 Kb containing the LHFPL3 region of chromosome 7.
Figure JPOXMLDOC01-appb-T000009
 　第１１染色体のGLB1L3領域を含む300Kbについて、この結果を表１０及び図１０に示す。
Figure JPOXMLDOC01-appb-T000009
 The results are shown in Table 10 and FIG. 10 for 300 Kb including the GLB1L3 region of chromosome 11.
Figure JPOXMLDOC01-appb-T000010
 　第１８染色体のZNF407領域を含む500Kbについて、この結果を表１１及び図１１に示す。
Figure JPOXMLDOC01-appb-T000010
 The results are shown in Table 11 and FIG. 11 for 500 Kb containing the ZNF407 region of chromosome 18.
Figure JPOXMLDOC01-appb-T000011
 　第１染色体のPAX7領域を含む300Kbについて、この結果を表１２及び図１２に示す。
Figure JPOXMLDOC01-appb-T000011
 The results are shown in Table 12 and FIG. 12 for 300 Kb including the PAX7 region of the first chromosome.
Figure JPOXMLDOC01-appb-T000012
 　第１染色体のPTPRF領域を含む300Kbについて、この結果を表１３及び図１３に示す。
Figure JPOXMLDOC01-appb-T000012
 The results are shown in Table 13 and FIG. 13 for 300 Kb including the PTPRF region of the first chromosome.
Figure JPOXMLDOC01-appb-T000013
 　第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）領域を含む500Kbについて、この結果を表１４及び図１４に示す。
Figure JPOXMLDOC01-appb-T000013
 The results are shown in Table 14 and FIG. 14 for 500 Kb including the 1q12-q21.1 region (including CHD1L and / or FMO5) of the first chromosome.
Figure JPOXMLDOC01-appb-T000014
 　第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）領域を含む3000Kbについて、この結果を表１５及び図１５に示す。
Figure JPOXMLDOC01-appb-T000014
 The results are shown in Table 15 and FIG. 15 for 3000 Kb including the 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) region of the first chromosome.
Figure JPOXMLDOC01-appb-T000015
 　第１染色体のFAM5B及び／又はASTN1領域を含む300Kbについて、この結果を表１６及び図１６に示す。
Figure JPOXMLDOC01-appb-T000015
 The results are shown in Table 16 and FIG. 16 for 300 Kb containing the FAM5B and / or ASTN1 region of chromosome 1.
Figure JPOXMLDOC01-appb-T000016
 　第１染色体のPKP1領域を含む300Kbについて、この結果を表１７及び図１７に示す。
Figure JPOXMLDOC01-appb-T000016
 The results are shown in Table 17 and FIG. 17 for 300 Kb including the PKP1 region of the first chromosome.
Figure JPOXMLDOC01-appb-T000017
 　第２染色体のKLHL29, FLJ14126領域を含む500Kbについて、この結果を表１８及び図１８に示す。
Figure JPOXMLDOC01-appb-T000017
 The results are shown in Table 18 and FIG. 18 for 500 Kb containing the KLHL29 and FLJ14126 regions of the second chromosome.
Figure JPOXMLDOC01-appb-T000018
 　第３染色体のTHRB領域を含む500Kbについて、この結果を表１９及び図１９に示す。
Figure JPOXMLDOC01-appb-T000018
 The results are shown in Table 19 and FIG. 19 for 500 Kb including the THRB region of the third chromosome.
Figure JPOXMLDOC01-appb-T000019
 　第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171領域を含む500Kbについて、この結果を表２０及び図２０に示す。
Figure JPOXMLDOC01-appb-T000019
 The results are shown in Table 20 and FIG. 20 for 500 Kb containing MED12L and / or CLRN10S and / or GPR171 region of chromosome 3.
Figure JPOXMLDOC01-appb-T000020
 　第４染色体のSORBS2領域を含む500Kbについて、この結果を表２１及び図２１に示す。
Figure JPOXMLDOC01-appb-T000020
 The results for 500 Kb including the SORBS2 region of chromosome 4 are shown in Table 21 and FIG.
Figure JPOXMLDOC01-appb-T000021
 　第５染色体のMAST4領域を含む600Kbについて、この結果を表２２及び図２２に示す。
Figure JPOXMLDOC01-appb-T000021
 The results are shown in Table 22 and FIG. 22 for 600 Kb including the MAST4 region of chromosome 5.
Figure JPOXMLDOC01-appb-T000022
 　第５染色体のGLRX, C5orf27領域を含む200Kbについて、この結果を表２３及び図２３に示す。
Figure JPOXMLDOC01-appb-T000022
 The results are shown in Table 23 and FIG. 23 for 200 Kb including the GLRX and C5orf27 regions of the fifth chromosome.
Figure JPOXMLDOC01-appb-T000023
 　第５染色体のEBF1領域を含む500Kbについて、この結果を表２４及び図２４に示す。
Figure JPOXMLDOC01-appb-T000023
 The results are shown in Table 24 and FIG. 24 for 500 Kb containing the EBF1 region of chromosome 5.
Figure JPOXMLDOC01-appb-T000024
 　第５染色体のDOCK2領域を含む500Kbについて、この結果を表２５及び図２５に示す。
Figure JPOXMLDOC01-appb-T000024
 The results are shown in Table 25 and FIG. 25 for 500 Kb including the DOCK2 region of chromosome 5.
Figure JPOXMLDOC01-appb-T000025
 　第６染色体の6p21.31-p21.3（HLA-DPA1を含む）領域を含む1000Kbについて、この結果を表２６及び図２６に示す。
Figure JPOXMLDOC01-appb-T000025
 The results are shown in Table 26 and FIG. 26 for 1000 Kb containing the 6p21.31-p21.3 (including HLA-DPA1) region of chromosome 6.
Figure JPOXMLDOC01-appb-T000026
 　第６染色体のLOC100132919領域を含む200Kbについて、この結果を表２７及び図２７に示す。
Figure JPOXMLDOC01-appb-T000026
 The results are shown in Table 27 and FIG. 27 for 200 Kb containing the LOC100132919 region of chromosome 6.
Figure JPOXMLDOC01-appb-T000027
 　第７染色体のAAA1, NPSR1領域を含む600Kbについて、この結果を表２８及び図２８に示す。
Figure JPOXMLDOC01-appb-T000027
 The results are shown in Table 28 and FIG. 28 for 600 Kb containing AAA1, NPSR1 region of chromosome 7.
Figure JPOXMLDOC01-appb-T000028
 　第７染色体のELMO1領域を含む700Kbについて、この結果を表２９及び図２９に示す。
Figure JPOXMLDOC01-appb-T000028
 The results are shown in Table 29 and FIG. 29 for 700 Kb containing the ELMO1 region of chromosome 7.
Figure JPOXMLDOC01-appb-T000029
 　第８染色体のTNKS領域を含む500Kbについて、この結果を表３０及び図３０に示す。
Figure JPOXMLDOC01-appb-T000029
 The results are shown in Table 30 and FIG. 30 for 500 Kb containing the TNKS region of chromosome 8.
Figure JPOXMLDOC01-appb-T000030
 　第８染色体のANGPT1領域を含む500Kbについて、この結果を表３１及び図３１に示す。
Figure JPOXMLDOC01-appb-T000030
 The results are shown in Table 31 and FIG. 31 for 500 Kb containing the ANGPT1 region of chromosome 8.
Figure JPOXMLDOC01-appb-T000031
 　第９染色体のPGM5領域を含む200Kbについて、この結果を表３２及び図３２に示す。
Figure JPOXMLDOC01-appb-T000031
 The results are shown in Table 32 and FIG. 32 for 200 Kb containing the PGM5 region of chromosome 9.
Figure JPOXMLDOC01-appb-T000032
 　第９染色体のTMC1領域を含む500Kbについて、この結果を表３３及び図３３に示す。
Figure JPOXMLDOC01-appb-T000032
 The results are shown in Table 33 and FIG. 33 for 500 Kb containing the TMC1 region of chromosome 9.
Figure JPOXMLDOC01-appb-T000033
 　第９染色体のROR2領域を含む500Kbについて、この結果を表３４及び図３４に示す。
Figure JPOXMLDOC01-appb-T000033
 The results are shown in Table 34 and FIG. 34 for 500 Kb containing the ROR2 region of chromosome 9.
Figure JPOXMLDOC01-appb-T000034
 　第９染色体のPPP6C, C9orf126領域を含む500Kbについて、この結果を表３５及び図３５に示す。
Figure JPOXMLDOC01-appb-T000034
 The results are shown in Table 35 and FIG. 35 for 500 Kb containing the PPP6C, C9orf126 region of the ninth chromosome.
Figure JPOXMLDOC01-appb-T000035
 　第１０染色体のGRID1領域を含む1000Kbについて、この結果を表３６及び図３６に示す。
Figure JPOXMLDOC01-appb-T000035
 The results are shown in Table 36 and FIG. 36 for 1000 Kb including the GRID1 region of chromosome 10.
Figure JPOXMLDOC01-appb-T000036
 　第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）領域を含む1000Kbについて、この結果を表３７及び図３７に示す。
Figure JPOXMLDOC01-appb-T000036
 The results are shown in Table 37 and FIG. 37 for 1000 Kb containing the 11p11.2 region of chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160).
Figure JPOXMLDOC01-appb-T000037
 　第１１染色体のOR5R1領域を含む200Kbについて、この結果を表３８及び図３８に示す。
Figure JPOXMLDOC01-appb-T000037
 The results are shown in Table 38 and FIG. 38 for 200 Kb containing the OR5R1 region of chromosome 11.
Figure JPOXMLDOC01-appb-T000038
 　第１１染色体のMS4A7, MS4A14領域を含む300Kbについて、この結果を表３９及び図３９に示す。
Figure JPOXMLDOC01-appb-T000038
 The results are shown in Table 39 and FIG. 39 for 300 Kb containing the MS4A7 and MS4A14 regions of chromosome 11.
Figure JPOXMLDOC01-appb-T000039
 　第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1領域を含む300Kbについて、この結果を表４０及び図４０に示す。
Figure JPOXMLDOC01-appb-T000039
 The results are shown in Table 40 and FIG. 40 for 300 Kb containing the MAP6 and / or GDPD5 and / or SERPINH1 region of chromosome 11.
Figure JPOXMLDOC01-appb-T000040
 　第１１染色体の11q23-24(PCSK7, RNF214)領域を含む200Kbについて、この結果を表４１及び図４１に示す。
Figure JPOXMLDOC01-appb-T000040
 The results are shown in Table 41 and FIG. 41 for 200 Kb containing the 11q23-24 (PCSK7, RNF214) region of chromosome 11.
Figure JPOXMLDOC01-appb-T000041
 　第１２染色体のTAOK3領域を含む500Kbについて、この結果を表４２及び図４２に示す。
Figure JPOXMLDOC01-appb-T000041
 The results are shown in Table 42 and FIG. 42 for 500 Kb containing the TAOK3 region of chromosome 12.
Figure JPOXMLDOC01-appb-T000042
 　第１２染色体のSTX2領域を含む300Kbについて、この結果を表４３及び図４３に示す。
Figure JPOXMLDOC01-appb-T000042
 The results are shown in Table 43 and FIG. 43 for 300 Kb containing the STX2 region of chromosome 12.
Figure JPOXMLDOC01-appb-T000043
 　第１３染色体のCARS2領域を含む300Kbについて、この結果を表４４及び図４４に示す。
Figure JPOXMLDOC01-appb-T000043
 The results are shown in Table 44 and FIG. 44 for 300 Kb containing the CARS2 region of chromosome 13.
Figure JPOXMLDOC01-appb-T000044
 　第１５染色体のCYP19A1領域を含む500Kbについて、この結果を表４５及び図４５に示す。
Figure JPOXMLDOC01-appb-T000044
 The results are shown in Table 45 and FIG. 45 for 500 Kb containing the CYP19A1 region of chromosome 15.
Figure JPOXMLDOC01-appb-T000045
 　第１７染色体のCA10領域を含む700Kbについて、この結果を表４６及び図４６に示す。
Figure JPOXMLDOC01-appb-T000045
 The results are shown in Table 46 and FIG. 46 for 700 Kb containing the CA10 region of chromosome 17.
Figure JPOXMLDOC01-appb-T000046
 　第１８染色体のLOC643542領域を含む500Kbについて、この結果を表４７及び図４７に示す。
Figure JPOXMLDOC01-appb-T000046
 The results are shown in Table 47 and FIG. 47 for 500 Kb containing the LOC643542 region of chromosome 18.
Figure JPOXMLDOC01-appb-T000047
 　第２０染色体のPTPRT領域を含む1200Kbについて、この結果を表４８及び図４８に示す。
Figure JPOXMLDOC01-appb-T000047
 The results are shown in Table 48 and FIG. 48 for 1200 Kb containing the PTPRT region of chromosome 20.
Figure JPOXMLDOC01-appb-T000048
 　第２１染色体のITSN1領域を含む500Kbについて、この結果を表４９及び図４９に示す。
Figure JPOXMLDOC01-appb-T000048
 The results are shown in Table 49 and FIG. 49 for 500 Kb containing the ITSN1 region of chromosome 21.
Figure JPOXMLDOC01-appb-T000049
 　第２染色体のLRP2領域を含む500Kbについて、この結果を表５０及び図５０に示す。
Figure JPOXMLDOC01-appb-T000049
 The results are shown in Table 50 and FIG. 50 for 500 Kb containing the LRP2 region of the second chromosome.
Figure JPOXMLDOC01-appb-T000050
 　第１１染色体のAPIP, PDHX領域を含む300Kbについて、この結果を表５１及び図５１に示す。
Figure JPOXMLDOC01-appb-T000050
 The results are shown in Table 51 and FIG. 51 for 300 Kb including APIP and PDHX regions of chromosome 11.
Figure JPOXMLDOC01-appb-T000051
 　第１２染色体のCUX2領域を含む500Kbについて、この結果を表５２及び図５２に示す。
Figure JPOXMLDOC01-appb-T000051
 The results are shown in Table 52 and FIG. 52 for 500 Kb including the CUX2 region of chromosome 12.
Figure JPOXMLDOC01-appb-T000052
 　第１７染色体のTOM1L1領域を含む200Kbについて、この結果を表５３及び図５３に示す。
Figure JPOXMLDOC01-appb-T000052
 The results are shown in Table 53 and FIG. 53 for 200 Kb containing the TOM1L1 region of chromosome 17.
Figure JPOXMLDOC01-appb-T000053
 　表２～５３におけるRs Idはrs番号を、Chromosomeは染色体を、PositionはNCBI(v36.1)番号を、Astat2 P Value(2x2)はｐ値を表す。
Figure JPOXMLDOC01-appb-T000053
 In Tables 2 to 53, Rs Id represents the rs number, Chromosome represents the chromosome, Position represents the NCBI (v36.1) number, and Astat2 P Value (2x2) represents the p value.
　本明細書で引用した全ての刊行物、特許および特許出願をそのまま参考として本明細書にとり入れるものとする。 All publications, patents and patent applications cited in this specification shall be incorporated into the present specification as they are.
　本発明は、生命科学、医学、眼科学及び診断に利用可能である。 The present invention can be used for life science, medicine, ophthalmology and diagnosis.

Claims (10)

  1. ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位の塩基を同定することを含む、正常眼圧緑内障の検査方法。 Includes the region containing ELOVL5 of human chromosome 6, the region containing SRBD1 of human chromosome 2, the region containing ARPP-21 of human chromosome 3, the region containing EPHA5 of human chromosome 4, and the GMDS of human chromosome 6. A region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, human Region containing GLB1L3 of chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21.1 of human chromosome 1 ( Region containing CHD1L and / or FMO5), region containing 1q21.2-q21.3 of human chromosome 1 (including FDPS and / or ASH1L and / or KCNN3), FAM5B of human chromosome 1 and / or A region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2, and / or Is a region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, MAST4 of human chromosome 5 A region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21.3 of human chromosome 6 (Including HLA-DPA1), a region containing LOC100132919 of human chromosome 6, a region containing AAA1 and / or NPSR1 of human chromosome 7, a region containing ELMO1 of human chromosome 7, A region containing TNKS, a region containing ANGPT1 of human chromosome 8, a region containing PGM5 of human chromosome 9, a region containing TMC1 of human chromosome 9, a region containing ROR2 of human chromosome 9, and the human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing region, human first Identifying normal pressure glaucoma comprising identifying the base of at least one polymorphic site in at least one region selected from the group consisting of a region comprising CUX2 of a chromosome and a region comprising TOM1L1 of human chromosome 17. Inspection method.
  2. ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs222450、rs9474394、rs2816344、rs2816341、rs2518579、rs2518578、rs9367511、rs6915699、rs6930045、rs9370188、rs9382180、rs9382181、rs4486010、rs2816379、rs6939730、rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs10948744、rs12183976、rs2562898、rs735860、rs715441、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201、rs9367529、rs12209741、rs7744451、rs6904083、rs6904376、rs9367532、rs2067833、rs9382212、rs2139077、rs2397146、rs7742367、rs9474576、rs622447、rs3736729、rs13212365及びrs761141からなる群より選択され、
    　ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs11686431、rs7580559、rs3908093、rs2343412、rs12623996、rs7573149、rs918810、rs6721199、rs7579209、rs10194925、rs17033378、rs2343466、rs17033398、rs6737172、rs4953226、rs3851333、rs12473388、rs11681887、rs35608719、rs11888802、rs11678872、rs2343468、rs13003019、rs6760244、rs12471726、rs2081297、rs10460504、rs7562458、rs4953230、rs4952763、rs6719211、rs1014454、rs3755070、rs3213787、rs10210691、rs3770251、rs4455206、rs3755076、rs3770254、rs11125017、rs3770264、rs10205197、rs10427308、rs17033745、rs3770278、rs17322370、rs6736954、rs10427402、rs4476395、rs13023749、rs17033801、rs755652、rs748573、rs6708810、rs6710581、rs12712945、rs17033871、rs3755082、rs6544840、rs7599740、rs11884064、rs7596942、rs7565326、rs17323037、rs1916231、rs1517001、rs1522988、rs614281、rs582213、rs650508、rs666334、rs17033965、rs556650、rs2204204、rs3795863、rs2285024、rs505310、rs10490342、rs612717、rs10490341、rs656823、rs563601、rs609573、rs6746467、rs637889、rs10495926、rs1522986、rs1522987、rs6544843及びrs6724488からなる群より選択され、
    　ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs1523048、rs1523029、rs12487524、rs1403468、rs872133、rs1523040、rs1523041、rs13069451、rs12629480、rs1357449、rs6801949、rs17033355、rs9873254、rs9839823、rs6794354、rs6794373、rs12637211、rs9855328、rs2037538、rs2037539、rs1523038、rs11718271、rs1608314、rs2197728、rs9311101、rs10490870、rs17033506、rs12634096、rs2359774、rs9860326、rs4678788、rs3213953、rs6799641、rs17201627、rs4678789、rs12632607、rs11129660、rs11129662、rs17033672、rs17280201、rs6779091、rs3772395、rs9872664、rs1963934、rs35102908、rs4678802、rs4678803、rs6550367、rs17033738、rs6801590、rs17033748、rs9865772、rs17033755、rs17228111、rs2016955、rs2016975、rs735353、rs11920715、rs1378481、rs17814981、rs1455489、rs4678509、rs10510667、rs6799649、rs6799609、rs17033836、rs4234248、rs6770245、rs10865865、rs7615307、rs9845811、rs17033961、rs1488092、rs10461001及びrs17033999からなる群より選択され、
    　ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs170654、rs1514271、rs2063419、rs13102419、rs11131589、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs4860651、rs11938753、rs1376417、rs10025570、rs1376416、rs2084682、rs7658065、rs9312144、rs1376412、rs17086181、rs17086185、rs6847413、rs2198103、rs12509018、rs17082122、rs6823779、rs17086224、rs1451170、rs4289492、rs4371663、rs9986026、rs9991256、rs4267782、rs7660334、rs6815080、rs11737314、rs4365778、rs7673091、rs4320185、rs4604104、rs7684022、rs4860679、rs6844942、rs12644315、rs4599467、rs6834811、rs4320186、rs4487412、rs7667410、rs4611975、rs4370201、rs4438803及びrs4608860からなる群より選択され、
    　ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs11966212、rs2143396、rs6911992、rs9378593、rs9392253、rs9378594、rs2050158、rs9391900、rs6596786、rs2235706、rs9378596、rs1997773、rs6926322、rs7754106、rs7750178、rs742520、rs2210370、rs6940618、rs349100、rs9405444、rs6932005、rs4959523、rs10484953、rs464778、rs115705、rs1013185、rs11242672、rs463641、rs4959525、rs369656、rs459162、rs127091、rs4959530、rs463264、rs7757477、rs448915、rs444018、rs443971、rs9391913、rs238048、rs238050、rs9378605、rs2459602、rs2438074、rs12191625、rs2438077、rs2496292、rs2496301、rs2438083、rs977674、rs977673、rs17259747、rs1437288、rs7772349、rs6596805、rs1347656、rs6925983、rs1550199、rs11242676、rs7744559、rs11966550、rs9378290、rs9405136、rs9405470、rs9392285、rs9405137、rs9405471、rs746095、rs9378623、rs9378292、rs1711957、rs7742720、rs9378629、rs7741690、rs9328052、rs9328053、rs1922938、rs2745636、rs2816242、rs932410、rs1474721、rs9392296、rs9502950、rs6907725、rs9405484、rs4443540、rs4355648、rs9328058、rs9328059、rs2569866、rs6935712、rs6935896、rs6937266、rs6925228、rs11242704、rs2816286、rs2816287、rs6596833、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs2317966、rs9392305、rs9501738、rs2569839、rs9328061、rs9378300、rs2816221、rs6916316、rs2281272、rs2569824、rs9405496、rs1810496、rs2814827、rs7759035、rs9502997、rs2814811、rs2317964、rs9378304、rs2569854、rs12206340、rs4538755、rs9378305、rs9503011、rs9405505、rs9503015、rs9501762、rs9405506、rs12197419、rs7765344、rs7765461、rs1013303、rs3800046、rs689035、rs2318108、rs6919059、rs6928276、rs226456、rs9378314、rs1157673、rs1157675、rs9391933、rs9328071、rs3778533、rs1028714、rs3800094、rs3778539、rs6596857、rs7776397、rs6596858、rs9378661、rs3823279、rs3800122、rs10484693、rs17772389、rs4959160、rs3778555、rs4463305、rs3800140、rs17134506、rs3800142、rs3800143、rs3800144、rs3800146、rs2761234、rs9405156、rs17134549、rs1408002、rs1830733、rs1830734、rs10223785、rs9405157、rs7772545、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs12212324、rs9392353、rs11242730、rs4580917、rs6910252、rs11242733、rs9503080、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs17134693、rs3800156、rs11242740、rs4959635、rs3800159、rs3778557、rs3800168、rs4959642、rs234930、rs9392372、rs234915、rs234914、rs3800184、rs234932、rs6903476、rs3778568、rs9405550、rs17134819、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs4413658、rs7449538、rs9503158、rs6902556、rs6925653、rs4281006、rs12210286、rs12213061、rs4959663、rs9501836、rs6911665、rs13200914、rs17135028、rs4959184、rs11242770、rs9328099、rs12206851、rs6904395、rs17609498、rs742487、rs4959185、rs9391949、rs9391950、rs6899721、rs1610416、rs3924452、rs10458144、rs9501850、rs9503199、rs4959677、rs35374935、rs2449448、rs1772982、rs1680885、rs2794569、rs2624936、rs12196957、rs2624933、rs1773000、rs1773001、rs1614248、rs1616044、rs2624917、rs2624916及びrs6899711からなる群より選択され、
    　ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2248373、rs2248459、rs2248462、rs2248617、rs3749946、rs2523650、rs2904776、rs2516422、rs2905747、rs9267247、rs2395034、rs3095229、rs3131631、rs2516486、rs2734573、rs3115537、rs2516478、rs2071593、rs3219183、rs13215091、rs1799964、rs1052248、rs9348876、rs2857697、rs2736172、rs1046089、rs2255741、rs760293、rs2077102、rs3130048、rs2844463、rs805301、rs805300、rs805297、rs707921、rs2242655、rs707974、rs805268、rs805267、rs9378164、rs707918、rs805292、rs2299851、rs707939、rs707937、rs480092、rs2075800、rs2763979、rs11965547、rs486416、rs644045、rs537160、rs2072633、rs522162、rs550513、rs9296003、rs406936及びrs492899からなる群より選択され、
    　ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs602698、rs678116、rs649930、rs643677、rs592698、rs675053、rs612557、rs629364、rs627967、rs628203、rs2771425、rs9355655、rs10499309、rs1041566、rs12530454、rs7753885、rs9347236、rs6455585、rs6931414、rs10447366、rs9457403、rs9355246、rs4709219、rs4708797、rs4709226、rs4709235、rs6925091、rs3799195、rs6913912、rs894124、rs6903405、rs6901469、rs9364496、rs7759006、rs6455600、rs2129209、rs6455601、rs9456350、rs3123094、rs9456352、rs3102970、rs6455604、rs3127188、rs3127194、rs3127196、rs3102966、rs3127168、rs923198、rs6924755、rs2361472、rs4569991、rs9457516、rs9456363、rs9365009、rs3923902及びrs12207795からなる群より選択され、
    　ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs3807826、rs7802863、rs3757521、rs3757520、rs3807823、rs1861032、rs17145870、rs7805508、rs6977682、rs3807815、rs1008038、rs3807811、rs11769978、rs3779356、rs3807807、rs3807806、rs7455929、rs6463790、rs4620183、rs12668479、rs17147407、rs11762595、rs12702719、rs17147608、rs12154895、rs17403198、rs16873367、rs42949、rs2349188、rs6463805、rs7811039、rs10247446、rs10270530、rs7795595、rs6945018、rs17148966、rs1476623、rs10246412、rs17404198、rs6463813、rs17149337、rs17404218、rs11976158、rs10244689、rs6978212、rs757704、rs2214694、rs2189904、rs765855、rs17150199、rs10261060、rs4401754、rs10266489、rs5018942、rs4556000、rs10278603、rs7787432、rs6959052、rs17150410、rs17150472、rs17150479、rs17150761、rs10237485、rs4720785、rs972247、rs1859274、rs10238726、rs6970999、rs17151821、rs7456267、rs6963180、rs10257265、rs970526、rs977458、rs13240427及びrs17154007、並びにNCBI(v36.1)8484291からなる群より選択され、
    　ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs41521、rs2188486、rs977641、rs17389507、rs10274138、rs17136882、rs13234807、rs7794181、rs7787988、rs7787976、rs17331134、rs1557689、rs6465984、rs7798273、rs2188494、rs1468143、rs10953427、rs2214087、rs4730006、rs6952170、rs17137313、rs4727599、rs17137382、rs10228106、rs42181、rs4730010、rs11763758、rs17137711、rs11763095、rs6977743、rs4520098、rs10216261、rs11972050、rs12539136、rs756669、rs41037、rs41038、rs28253、rs41058、rs9649272、rs6949801、rs9987005、rs6465994、rs6465995、rs1477110、rs12216618、rs10254402、rs6969323、rs9641335、rs10272959、rs3919550、rs4730030、rs10246540、rs4730031、rs2891730、rs995661、rs10487221、rs10487222、rs11773248、rs11983223、rs6943307、rs7782065、rs7801387、rs12705261、rs12531723、rs17269890、rs4730038、rs4584085、rs10216010、rs17141284、rs17141299、rs10953450、rs6466018、rs4530975、rs12705276、rs4283980及びrs2470965、並びにNCBI(v36.1) 103849313、104068646及び104196627からなる群より選択され、
    　ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs470713、rs470935、rs641024、rs11606866、rs7131644、rs10894784、rs1031381、rs522134、rs4362160、rs473041、rs498602、rs554874、rs1144225、rs1595895、rs1146192、rs4936229、rs1144219、rs2510356、rs553231、rs512359、rs568044、rs10894798、rs10894799、rs11223765、rs10894800、rs7940114、rs10894801、rs10791357、rs3741100、rs3741098、rs7113199、rs1866769、rs1866768及びrs1561613からなる群より選択され、
    　ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs3794941、rs17055278、rs514931、rs494721、rs17055426、rs2896769、rs12717033、rs7227977、rs10871527、rs10514139、rs17832851、rs17055756、rs1473224、rs2628125、rs8085262、rs8089151、rs2628123、rs4891199、rs17055919、rs10514148、rs17055185、rs2404482、rs10514149、rs4337381、rs2959165、rs12456768、rs4891217、rs9945585、rs9961644、rs9961742、rs9952375、rs13381156、rs9319675、rs2120144、rs8096648、rs17056218、rs2289609、rs4891228、rs1396098、rs894575、rs10871567、rs7242893及びrs7239800からなる群より選択され、
    　ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs3000058、rs2816030、rs16862061、rs2816040、rs2816046、rs4920334、rs4920516、rs4920335、rs2816064、rs6704504、rs1934057、rs2298893、rs2743208、rs2076021、rs2076020、rs2236826、rs2282704、rs2282699、rs624761、rs851123、rs2236817、rs685300、rs2056446、rs2841078、rs4920344、rs6669544、rs4076925、rs6603910、rs11261070、rs7539659、rs11261074、rs7411058、rs4920545、rs6684577及びrs12565195からなる群より選択され、
    　ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs2494997、rs1999674、rs2842180、rs2255632、rs2251804、rs1334973、rs6687571、rs2039528、rs2819341、rs10890251、rs2367617、rs11210864、rs2782641、rs11210871、rs10890257、rs12058744、rs11210879、rs11210886、rs516790、rs641365、rs673485、rs643445、rs10789438、rs11210892、rs617521、rs660899、rs2274465、rs10789439、rs489319、rs607062、rs10789442及びrs3791035、並びにNCBI(v36.1)43760103からなる群より選択され、
    　ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200rs12122453、rs12122534、rs4950474、rs4950475、rs6593810、rs6657631、rs21327、rs517201、rs575115、rs2031481、rs2477568、rs2477569、rs692963、rs535827、rs4950361、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs2077749、rs17159914、rs6593745、rs2120003、rs10900325、rs2354432、rs6670503、rs1470261、rs6703187、rs10793652、rs7537483、rs7537703、rs1890038、rs3820130、rs3737845、rs17160062、rs3766525、rs4950315、rs17356240、rs10494244、rs6683839、rs10793656、rs17360443、rs3753433、rs12033407、rs7554833、rs10793661、rs10736837、rs10900336、rs7520661、rs4950409、rs2353983、rs6658836、rs17360812、rs6656156、rs12759145、rs12049491、rs10793682、rs4950431、rs7539416、rs2353969、rs4504949、rs17160205、rs2353967、rs12728058、rs6688308、rs11589438、rs6688154、rs6678706、rs4950436、rs7519891、rs11240053、rs11240054、rs11240055、rs7556087、rs7518276、rs2644579、rs2353951、rs2644577、rs6674761、rs2644566、rs2803535、rs17160256、rs12406844、rs17160264、rs612963、rs586000、rs17160295、rs644550及びrs17160305からなる群より選択され、
    　ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs10752613、rs11583896、rs16835600、rs4434872、rs4567311、rs4363451、rs9427232、rs4845576、rs4520447、rs4845578、rs11585416、rs4845584、rs12033835、rs11581644、rs10908557、rs6701341、rs2297898、rs12048137、rs11264875、rs2066134、rs2494663、rs6671166、rs4845600、rs16835819、rs4521985、rs4620534、rs9803857、rs11265310、rs2340473、rs1194596、rs1212352、rs6672010、rs6702754、rs2274988、rs2297607、rs4414034、rs6696089、rs11265607、rs6427631、rs6427658、rs6694817、rs4537545、rs4845626、rs11265618、rs10752641、rs4240872、rs4474240、rs6700296、rs11265627、rs6691727、rs6687112、rs6427716、rs12136771、rs7553602、rs6660775、rs1127314、rs1127313、rs2131902、rs2229857、rs3766923、rs3766922、rs12125166、rs2335230、rs7531982、rs7533471、rs11264233、rs10796927、rs2335252、rs2036627、rs6699979、rs1995662、rs6664817、rs11264249、rs6426905、rs960182、rs16836320、rs868108、rs4845390、rs10494300、rs1051614、rs6666341、rs11808053、rs883319、rs1777910、rs951240ｖ、rs951241、rs9970364、rs1984285、rs6681725、rs16836414、rs10796934、rs10908445、rs4845678、rs4845679、rs4845681、rs12130132、rs10908448、rs4845690、rs4845406、rs10908455、rs7368345、rs10908456、rs4971079、rs4276913、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822519、rs822508、rs1749405、rs1749409、rs572609、rs3768280、rs2275078、rs2016251、rs1475766、rs12035615、rs4661146、rs6700693、rs10908489、rs11264449、rs2253677、rs2241110、rs2853641、rs2075163、rs2241107、rs1052053、rs1052067、rs759330、rs7542798、rs2253358、rs2842880、rs16837272、rs2287023、rs2246476、rs2248273、rs11264467、rs7522860、rs10908500、rs10494304、rs3795730、rs3762281、rs35478936、rs2274226、rs2985714、rs2842854、rs954916、rs6686886、rs11590409、rs4661040、rs7551781、rs16837376、rs11806983、rs1109751、rs11264486、rs3790458、rs1342442、rs12136856、rs10159180、rs1171564、rs1609666、rs728918、rs11264495、rs744224、rs4661184、rs879461、rs12742817、rs3795736、rs2236601、rs1046650及びrs3795737からなる群より選択され、
    　ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs7521610、rs16850728、rs227521、rs227519、rs10047146、rs10489307、rs972484、rs1402640、rs10913291、rs12094495、rs10798503、rs6425414、rs7515582、rs10913294、rs7534953、rs10913295、rs725416、rs12090000、rs12564343、rs12031932、rs12079554、rs554454、rs6660903、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs16851037、rs17315298、rs2861972、rs1883243、rs6660559、rs4652245、rs4140633、rs7528533、rs3946142、rs6658794、rs9425456、rs6672376、及びrs12025407からなる群より選択され、
    　ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1122396、rs1722755、rs6413916、rs831771、rs1404401、rs831767、rs16847944、rs831765、rs16847947、rs831764、rs16847951、rs831762、rs831753、rs16847994、rs831751、rs4915220、rs10157719、rs947379、rs12466、rs1592085、rs4915499、rs12134467、rs10158798、rs1954214、rs12046907、rs10920161、rs12117501、rs1997018、rs1880450、rs1857489、rs16848184、rs868381、rs854488、rs832169、rs832174、rs700469、rs860554rs1779301、rs2300293、rs2268156、rs832147、rs854502、rs1722780、rs1779293、rs854505、rs1572968、rs17425876、rs12143423、rs947377、rs10753899、rs17459837、rs6427900、rs1122481、rs2275862、rs11806184、rs2365652、rs2275860、rs947485、rs6671391、rs1256941、rs10800779、rs7553988、rs10920205、rs3887566、rs3888929、rs6427908及びrs12090950からなる群より選択され、
    　ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs2577720、rs2723120、rs10495742、rs2577717、rs6720565、rs12053097、rs12613333、rs7566157、rs17045229、rs875077、rs17045238、rs2723129、rs2577698、rs2954818、rs12989910、rs11125011、rs6742888、rs7564616、rs2723111、rs6544822、rs893430、rs737564、rs737565、rs747344、rs6727901、rs7570872、rs17045350、rs6544861、rs6756357、rs4665214、rs10172684、rs1653748、rs1465677、rs1864807、rs1864808、rs4665218、rs10169643、rs1368080、rs10490750、rs11677730、rs7601971、rs1653751、rs1653753、rs1368081、rs11678782、rs11678785、rs4497835、rs1653780、rs17445645、rs4665223、rs4284788、rs4665612、rs1709339、rs6544949rs17045574、rs6544966、rs4665230、rs583168、rs17045705、rs2280122、rs1548020、rs518113、rs497973、rs3806510、rs13386930、rs6721623、rs3795933、rs7560892、rs4233701、rs9261、rs7579413、rs12470949、rs12478701、rs2081302、rs12478744、rs2339853及びrs35379186からなる群より選択され、
    　ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6765461、rs6801153、rs1464010、rs7630879、rs6550848、rs826375、rs1667765、rs826378、rs6808673、rs2596623、rs17194828、rs1562736、rs9310730、rs2683535、rs7652337、rs7652444、rs2683542、rs1667739、rs1505302、rs6799431、rs17014338、rs826249、rs10510540、rs6772213、rs851719、rs6792783、rs1354605、rs866651、rs958892、rs826225、rs6550853、rs826223、rs826218、rs1466122、rs1449874、rs11719336、rs7625917、rs17787283、rs4858594、rs1449872、rs9849581、rs9863517、rs9843698、rs9867989、rs1667746、rs17787319、rs1505307、rs7640580、rs12639035、rs9810037、rs9833191、rs12630454、rs3951794、rs6781111、rs1505287、rs12495379、rs4858608、rs7624363、rs4640503、rs6550865、rs9839986、rs5014281、rs9831450、rs4241527、rs4858617、rs4858618、rs2196427、rs10490840、rs6788339、rs6765048及びrs892941からなる群より選択され、
    　ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs13088412、rs9837084、rs744876、rs571170、rs358954、rs9833515、rs6440716、rs358967、rs1993404、rs9883677、rs2048229、rs16863149、rs891666、rs1835668、rs6787683、rs16863204、rs16863208、rs16863229、rs3732755、rs3773614、rs1231521、rs3108727、rs3773619、rs7649855、rs16863264、rs2870518、rs3846072、rs6782715、rs1882014、rs16863287、rs10513391、rs3773621、rs10935835、rs9863821、rs9864095、rs1873619、rs7623356、rs1491981、rs6440735、rs3971192、rs7644001、rs16863323、rs6801273、rs9820422、rs16863336、rs1388622、rs3975404、rs10513394、rs6787801、rs9289836、rs3821663、rs7429509、rs3821664、rs1491974、rs9653953、rs17204501、rs17204508、rs4680406、rs12490051、rs16863364、rs11708767、rs11709550、rs3732769、rs10935844、rs2276765、rs2276766、rs16863376、rs6440741、rs6771904、rs6772196、rs3732771、rs9864533、rs4435614、rs17204557、rs6798252、rs4680440、rs4680443、rs13088575、rs6790903、rs9289840、rs4680474、rs4541381、rs4596123及びrs7612205、並びにNCBI(v36.1)152200518、152229595、152456055及び152609183からなる群より選択され、
    　ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10866277、rs12645545、rs12649063、rs7437897、rs11132327、rs10866278、rs6823490、rs6843640、rs6818789、rs2101307、rs6552895、rs6552896、rs6552897、rs12498673、rs10025265、rs2306707、rs3749579、rs6848934、rs2306703、rs11934819、rs4862558、rs4599460、rs4862559、rs6823546、rs11132334、rs5018568、rs904451、rs7677363、rs2030144、rs11132338、rs11132340、rs7669883、rs6858544、rs1027521、rs2173480、rs2173479、rs11132344、rs10084919、rs7677532、rs6835720、rs10024805、rs6834923、rs6812818、rs10015164、rs11132345、rs10024359、rs10000785、rs1039235、rs2310357、rs10028428、rs4862571、rs7684943、rs10021308、rs1566347、rs12504307、rs11132355、rs10028944、rs1499010、rs11724690、rs11940307、rs1566354、rs2648126、rs2648120、rs2648117、rs2648112、rs4861686、rs1026362、rs12643549、rs2310372、rs4862588、rs10031442、rs4637445、rs1947455、rs2278938、rs12641600、rs4862600、rs10002339、rs7694098、rs830829、rs830838、rs830841、rs2603731rs7697039、rs7697051、rs1356672、rs7679967、rs4861696、rs1519320及びrs12643213からなる群より選択され、
    　ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs7733618、rs12514219、rs4532318、rs6861487、rs7700850、rs4587034、rs7705086、rs16895307、rs16895308、rs6890124、rs4339298、rs4613646、rs6862416、rs4532319、rs10515011、rs16895357、rs7732647、rs4355471、rs4554157、rs12055346、rs16895417、rs17210621、rs7706654、rs6864239、rs6896102、rs4374700、rs16895456、rs6880657、rs6863239、rs16895458、rs11953193、rs10940078、rs4446417、rs9791090、rs33721、rs33728、rs2548712、rs33696、rs257711、rs33724、rs26384、rs7704890、rs7725568、rs30729、rs26383、rs27637、rs26382、rs9918275、rs258082、rs257699、rs257700、rs16895719、rs30731、rs16895744、rs1835136、rs36157、rs36155、rs544158、rs36144、rs36143、rs26923、rs16895768、rs463219、rs16895790、rs26921、rs192295、rs26929、rs26928、rs461702、rs460844、rs455938、rs464881、rs456775、rs154620、rs17217092、rs154618、rs10056426、rs152407、rs37568、rs734828、rs2280174、rs16896071、rs40206、rs706701、rs17218390、rs6863305、rs39664、rs34691、rs34693、rs10044452、rs34698、rs34699、rs4016246、rs1159201、rs2662227、rs27206、rs469300、rs467845、rs2545396、rs16896246、rs16896295、rs17221226、rs2287929及びrs16896325、並びにNCBI(v36.1)65944399からなる群より選択され、
    　ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs34896、rs34897、rs3777220、rs3777217、rs11738579、rs3777213、rs7736948、rs6556883、rs9314160、rs6876015、rs11135436、rs17085165、rs17085170、rs10040697、rs6884979、rs7702848、rs2080947、rs10476660、rs154454、rs147295、rs17085249、rs11741590、rs3777194、rs2270554、rs3777190、rs3777188及びrs4642392、並びにNCBI(v36.1)95206085からなる群より選択され、
    　ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs2913384、rs173423、rs244654、rs824854、rs824848、rs1095103、rs403334、rs10515769、rs2112262、rs33196、rs17056089、rs2042875、rs3843489、rs1541649、rs17056186、rs2116727、rs10067813、rs7709065、rs17056205、rs1368298、rs4704963、rs10070743、rs4704967、rs10056564、rs6875710、rs17643057、rs6883655、rs891903、rs10054046、rs6556373、rs4921537、rs6556377、rs13180086、rs6556379、rs6556381、rs1544754、rs883540、rs17056426、rs17056435、rs1363561、rs9313797、rs1422672、rs17056474、rs17717829、rs10515787、rs10515786、rs10515789、rs9637861、rs7442845、rs12659540、rs3862065及びrs270661からなる群より選択され、
    　ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs4493692、rs3797712、rs3797713、rs264881、rs36101422、rs264834、rs6879467、rs6883997、rs7721990、rs7713640、rs900464、rs264846、rs2161404、rs2306560、rs3816764、rs11134586、rs12515906、rs264844、rs2279318、rs264843、rs10063658、rs4867879、rs17736846、rs264838、rs12658902、rs2306558、rs262865、rs262840、rs262841、rs262842、rs155239、rs262848、rs262851、rs4867572、rs262852、rs746468、rs90213、rs17051884、rs262860、rs262859、rs10076580、rs6875474、rs185532、rs17669613、rs1013193、rs17669636、rs966595、rs17669654、rs13171272、rs261612、rs13163565、rs17737323、rs155074、rs261016、rs261597、rs166368、rs261633、rs10054135、rs261624、rs261625、rs17560224、rs4867895、rs168678、rs30080、rs30083、rs17670092、rs7717087、rs17737597、rs7729471、rs261039、rs261038、rs1482333、rs2291229、rs261021、rs261076、rs12515095、rs17646198、rs17560405、rs261067、rs261060、rs261006、rs261008、rs11740615、rs11741667、rs155023、rs11742527、rs978914、rs12522080、rs2624252、rs6896240、rs6862278、rs3860755、rs259897、rs259899、rs259900、rs259902、rs259903、rs6895199、rs259916、rs12659898、rs1422695、rs17738158、rs17561105、rs11134600、rs6893165、rs2161366、rs9313476、rs17738326、rs2287727、rs17738444、rs6884677、rs13152920、rs9790867、rs11134603、rs17738530、rs2134151、rs12055169、rs17738584、rs1316638、rs17072023、rs13361200、rs17738710、rs10462994、rs10462995、rs6890267、rs6871764、rs17671355、rs6555884、rs17562083、rs10516070及びrs955078からなる群より選択され、
    　ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs1044043、rs10484565、rs241438、rs1800454、rs241429、rs241427、rs4711312、rs2071482、rs4148882、rs12529313、rs9276815、rs20547、rs9276825、rs9276832、rs241404、rs241403、rs3101942、rs241400、rs3132132、rs151719、rs1050391、rs9378127、rs188245、rs3129305、rs176248、rs12216336、rs2894311、rs12191230、rs2395301、rs12192713、rs12199692、rs1044429、rs592625、rs399604、rs365066、rs3763341、rs4713603、rs4713604、rs6936620、rs2116264、rs1367731、rs439852、rs446853、rs9296069、rs440841、rs3128952、rs3130180、rs3097662、rs3128955、rs3130588、rs9277183、rs3097669、rs9277194、rs376877、rs6457710、rs3077、rs9348904、rs9296073、rs2856816、rs3135021、rs1431403、rs9277542、rs3128963、rs3128965、rs3128966、rs3117229、rs2068204、rs2179920、rs2295120、rs3117242、rs3128921、rs3128923、rs9296079、rs3117230、rs3128930、rs872956、rs9380343、rs6937034、rs6937061、rs9277637、rs3117039、rs3130233、rs3117016、rs2395351、rs3116985、rs3129249、rs3129248、rs1003979、rs2071025、rs2855459、rs439205、rs213208、rs461338、rs458679、rs455567、rs14398、rs3130267、rs3130014、rs211455、rs211453、rs10807124、rs411136、rs2772376、rs7747216、rs9469491、rs17627049、rs210137、rs9296095、rs210138、rs444697、rs1794681、rs9469529、rs4711332、rs12205634、rs1408711、rs1536041、rs2229637、rs10947427、rs3818527、rs3818528、rs3818530、rs4713659、rs594223、rs7759668、rs626156、rs498114、rs654682、rs16869412、rs10947432、rs3818532、rs9394163、rs12203688、rs4713670、rs4713671、rs622917、rs12189725、rs877187、rs4713674、rs4713677、rs943466、rs943467、rs755495、rs747692、rs943475、rs6929696、rs3806108、rs3828783、rs3763253、rs9366829、rs9394169、rs4713686及びrs10947441からなる群より選択され、
    　ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs1338657、rs9485685、rs9377361、rs9377365、rs9377366、rs9322660、rs9322661、rs2399802、rs17063309、rs680011、rs9499111、rs9404214、rs1569366、rs1569367、rs17443301、rs17063399、rs6906578及びrs7740643、並びにNCBI(v36.1)102984444からなる群より選択され、
    　ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs1156490、rs6462540、rs1419842、rs2392267、rs1419803、rs1419805、rs1419809、rs6977125、rs17169769、rs17169771、rs7778512、rs1419840、rs35114106、rs1019089、rs16878925、rs1362172、rs2392270、rs17831435、rs10951417、rs1468559、rs10486643、rs6951496、rs7458608、rs2893480、rs4723375、rs1419863、rs1419864、rs9639694、rs9639695、rs10951418、rs10215667、rs6971556、rs12673387、rs4723377、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs12672624、rs10486649、rs2893482、rs12672538、rs10486650、rs2392274、rs2079509、rs10243426、rs2097960、rs1362173、rs1458549、rs450463、rs1023555、rs1023556、rs2530548、rs2530549、rs2530550、rs1419794、rs2530565、rs1458544、rs2609226、rs9792042、rs2530567、rs2609218、rs323925、rs323912、rs10239860、rs1419791、rs17777040、rs17198254、rs17777663、rs17777675、rs17198982、rs17788843、rs324978、rs324981、rs324983、rs1419780、rs325464、rs17199659、rs17789420、rs17789642、rs17170015、rs17200455、rs10263313、rs17790181及びrs11768189からなる群より選択され、
    　ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs10277512、rs4720221、rs7787226、rs10951500、rs10274668、rs10255208、rs2006882、rs2392472、rs756507、rs2241152、rs7785934、rs7782979、rs17170754、rs3807162、rs3734948、rs741302、rs2041801、rs6966276、rs4723592、rs11769038、rs4723598、rs1882080、rs4723601、rs11982286、rs1986619、rs1882082、rs10268319、rs17170799、rs6957979、rs10225164、rs2293628、rs999744、rs17170820、rs17170826、rs17170830、rs1364373、rs13233995、rs6971267、rs7809487、rs1035582、rs2541103、rs2541074、rs2541075、rs2551069、rs1420421、rs6958656、rs10257460、rs12666532、rs1420422、rs17170915、rs10224438、rs7809365、rs6963276、rs6967358、rs6967403、rs10279544、rs4723619、rs17170955、rs2723969、rs6944921、rs6462746、rs1016321、rs2541082、rs4723631、rs2541089、rs2717975、rs10238916、rs2723952、rs12534004、rs2893540、rs2724006、rs2717983、rs2717990、rs2701004、rs2724007、rs2717992、rs2723996、rs9655380、rs2701003、rs2717993、rs2724003、rs2723980、rs2723990、rs2717948、rs2700992、rs6462758、rs2724014、rs2724016、rs1882079、rs2717954、rs13247953、rs2392495、rs10233634、rs12532031、rs4720246、rs7782999、rs1425124、rs1647801、rs2052688、rs2052687、rs10282309、rs10239693、rs17261508、rs10267165、rs918979、rs7777258、rs11767227、rs1647791、rs1732001、rs17171045、rs9655382及びrs6952260、並びにNCBI(v36.1)37495022からなる群より選択され、
    　ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs12680471、rs2085640、rs17149989、rs17730481、rs17663071、rs17663167、rs4841147、rs1458938、rs1458939、rs11786942、rs17674819、rs1466338、rs13253327、rs17150066、rs11777274、rs11249921、rs17150087、rs1380104、rs11997346、rs4841156、rs6991328、rs17150131、rs7817148、rs10100760、rs17150181、rs17150185、rs17733293、rs7835349、rs7013746、rs7016636、rs3989158、rs17150211、rs4841169、rs4841171、rs6985564、rs11991621、rs4840426、rs6992432、rs10503380、rs7013834、rs6980831、rs12681719、rs4840427、rs4841179、rs7832096、rs4474027、rs4457339、rs12674762、rs4535743、rs1393、rs4342598、rs11780274、rs13273033、rs4841197、rs7010270、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs11785739、rs17150478、rs11787443、rs2898223、rs7820917、rs7829463、rs7000483、rs1567837、rs17734290、rs12540961、rs7829733、rs2137790、rs13249584、rs7013686、rs7015101、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996、rs7828229、rs17150703、及びrs531564からなる群より選択され、
    　ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs12549261、rs10955436、rs6981257、rs11774921、rs11781710、rs1954724、rs6997025、rs1892764、rs16875775、rs11778352、rs2584372、rs2246255、rs2022958、rs2022949、rs16875901、rs1010824、rs2507799、rs10505100、rs11777978、rs16875983、rs9297393、rs7009229、rs13257393、rs4077322、rs11997995、rs10505105、rs4133396、rs4133395、rs4341141、rs10505107、rs11780324、rs35143736、rs17368715、rs17296616、rs17368821、rs10955450、rs1433178、rs2514850、rs1283653、rs2445351、rs1283659、rs16876122、rs1632130、rs1672143、rs16876200、rs2514867、rs1283706、rs1283703、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191、rs1298936、rs1368497、rs1529747、rs2916085、rs1368494、rs3847160、rs1654680、rs17301273、rs10086467、rs16876325、rs1283720、rs1433171、rs1433172、rs10216767、rs1583300、rs281708、rs10955457、rs10103715、rs281673、rs439896、rs281685、rs281696、rs2014769、rs281740及びrs190735、並びにNCBI(v36.1)108394240からなる群より選択され、
    　ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs3869296、rs7020465、rs11142449、rs11142461、rs10868851、rs13439981、rs7039076、rs265083、rs2131355、rs265087、rs265073、rs7861495、rs10869020、rs17085775、rs11795256、rs10869034、rs1411992、rs10869043、rs12343877、rs11142941、rs869950、rs7046236及びrs9644996からなる群より選択され、
    　ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs3012514、rs7846808、rs7027640、rs10781101、rs4526421、rs7853275、rs10869178、rs7864535、rs12004208、rs6560277、rs4573342、rs4132905、rs4073227、rs10121866、rs7044241、rs7855743、rs4373587、rs11143314、rs7047875、rs6560284、rs6560285、rs7857300、rs6560287、rs7866185、rs6560293、rs7026124、rs12346185、rs7041300、rs4307407、rs17095、rs10113863、rs7029452、rs6560297、rs7045535、rs13285932、rs10521449、rs13285999、rs10869190、rs9314799、rs1037031、rs2487471、rs2589623、rs2793153、rs2589615、rs969205、rs1796991、rs1838487、rs2589609、rs1663756、rs12351661、rs1663763、rs13298704及びrs2501914からなる群より選択され、
    　ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs6479357、rs9409602、rs10991978、rs10991988、rs7867934、rs1388966、rs902923、rs902922、rs10512215、rs1532230、rs12337820、rs7029450、rs2131304、rs10992027、rs9299395、rs1388967、rs4073736、rs4073735、rs9409652、rs10992075、rs7031729、rs17585790、rs16907725、rs16907728、rs4372069、rs16907761、rs16907764、rs17586213、rs7039620、rs16907768、rs10992090、rs3802379、rs3935382、rs4601388、rs4744101、rs4743852、rs10119449、rs7858240、rs7022147、rs1569141、rs10992124、rs7856144、rs7855417、rs6479374、rs1881385、rs16907863、rs12002851、rs1881392、rs10992137、rs7045226、rs11789730、rs16907923、rs12684524、rs7858435、rs10116326、rs16907979、rs10992161、rs6479386、rs3858082、rs7038823、rs7871522、rs10125466、rs10992178、rs10820926、rs6479389、rs10820927、rs7867072、rs1954599及びrs10992207からなる群より選択され、
    　ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs7022663、rs7024526、rs2289631、rs10986505、rs16927802、rs12001999、rs10819019、rs6478690、rs1017530、rs3824507、rs12352758、rs4838242、rs650599、rs7860360、rs2113352、rs7019234、rs7867749、rs2271746、rs16927930、rs10986618、rs10986626、rs12237026、rs463774、rs420423、rs10986641、rs10513445、rs393721、rs10819043、rs10986689、rs10986698、rs10986703、rs10986714、rs10986715、rs10986721、rs10986722、rs1463837、rs4837016、rs10126025、rs10986738、rs2819624及びrs3122938からなる群より選択され、
    　ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs17306253、rs10887498、rs12243608、rs1876887、rs2457451、rs2664403、rs2664394、rs1912274、rs1912322、rs744413、rs2664406、rs2664405、rs2616673、rs2175200、rs2175201、rs17105725、rs1912277、rs2457450、rs17105747、rs746992、rs7076174、rs4027581、rs11201743、rs4418740、rs17105793、rs12221324、rs17105805、rs7924009、rs11201759、rs11201775、rs3011700、rs2949380、rs17105842、rs3011704、rs2140661、rs1917136、rs17105866、rs1880389、rs884316、rs2949384、rs2949385、rs2140666、rs2949386、rs1106789、rs11201804、rs17105912、rs17105916、rs2352181、rs947596、rs2352099、rs7924131、rs7923188、rs7923344、rs1418396、rs7899222、rs10788472、rs10887538、rs2153828、rs7910835、rs7914815、rs7918491、rs2001417、rs2001416、rs10887540、rs7095652、rs12773130、rs12779841、rs10887544、rs11201871、rs10887549、rs10788476、rs2003111、rs7912451、rs11201882、rs2352178、rs7923926、rs7082134、rs4284352、rs6585995、rs6585996、rs5003944、rs7923310、rs884700、rs4934156、rs11201909、rs868042、rs12257526、rs12262754、rs11817682、rs12243396、rs1870156、rs2607830、rs17320915、rs2814322、rs2607840、rs11201944、rs17106434、rs2607822、rs10887563、rs10887564、rs2492738、rs1870161、rs2607839、rs1870165、rs2814340、rs1902678、rs2814349、rs1947567、rs2168725、rs1902680、rs2607833、rs1902676、rs1896527、rs6586003、rs12262612、rs6586004、rs17106584、rs7905184、rs10887578、rs10509530、rs1078789、rs10749537、rs12355013、rs7904985、rs10788500、rs10788501、rs10458771、rs2018507、rs10887608、rs4934207、rs4934208及びrs7083506からなる群より選択され、
    　ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs7124648、rs7128650、rs4587689、rs11039097、rs12796744、rs17197619、rs17790390、rs11039105、rs10501319、rs11039112、rs747650、rs7937410、rs17197710、rs1685404、rs2013867、rs901746、rs7118396、rs10838681、rs10501321、rs1051006、rs3816724、rs7124955、rs4752824、rs1052373、rs11570094、rs10769255、rs11039212、rs4992357、rs11605672、rs1534576、rs10742805、rs12419692、rs4752856、rs3817334、rs7120548、rs10838739、rs11039329、rs10742817、rs4752791、rs17788930、rs7114011、rs10838774、rs2305982、rs6485788、rs10838782、rs7924699、rs1872167、rs747782及びrs1681630からなる群より選択され、
    　ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10896302、rs17615246、rs10750820、rs1945245、rs3938998、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs1945213、rs1945211、rs7113069、rs11228306、rs12785840、rs10501353、rs1945203、rs585475、rs615231、rs617315、rs675991、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594、rs634955及びrs613050からなる群より選択され、
    　ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs1026250、rs10750931、rs7126121、rs11230241、rs10897026、rs12225299、rs10792264、rs7125753、rs11605188、rs1899571、rs11230258、rs11230261、rs7943967、rs4442568、rs10897047、rs2868121、rs7945665、rs10897049、rs4506675、rs10792267、rs2304935、rs2165832、rs10736703、rs4939347、rs2233244、rs950803、rs950802、rs3816270、rs2241920、rs10501383、s10897056、rs4939352、rs955019、rs4938943、rs11230304、rs3763850、rs2282524、rs10897061、rs2120182、rs12787520、rs4146870、rs4939364、rs1051756、rs1941032、rs17615252、rs17543397、rs8181503、rs7946021、rs4939391、rs2186919、rs2847222、rs2633277及びrs2847212、並びにNCBI(v36.1)59954904からなる群より選択され、
    　ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs565976、rs534179、rs2276443、rs532454、rs511190、rs566818、rs482458、rs1793412、rs1790149、rs1790155、rs1790154、rs668727、rs11600640、rs611449、rs11236449、rs661928、rs621305、rs11236452、rs7128888、rs7129014、rs688727、rs674503、rs606452、rs11236458、rs599816、rs660343、rs541993、rs601142、rs648930、rs611221、rs12574551、rs584046、rs640927、rs11236476、rs17134231、rs12282340、rs10160335、rs12281880、rs656007、rs479592、rs589443、rs4944086、rs10751245、rs7110142、rs7947980及びrs509530、並びにNCBI(v36.1)75005360からなる群より選択され、
    　ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs17120344、rs6589597、rs10790175、rs12420127、rs10892082、rs7107152、rs1242229、rs1784042、rs2269399、rs526602、rs664971、rs11216315、rs1263499、rs17120523、rs236919、rs528508、rs593245及びrs477036、並びにNCBI(v36.1)116617736からなる群より選択され、
    　ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs7297299、rs5745807、rs5745811、rs9739560、rs4767654、rs10638、rs9788041、rs11068799、rs11068803、rs10850953、rs7135008、rs11613924、rs7307331、rs9669474、rs7957463、rs10850956、rs2936840、rs904661、rs1726407、rs1726392、rs17440336、rs1277442、rs11068860、rs11068865、rs17512142、rs17440364、rs364823、rs418941、rs7974718、rs11068891、rs16948230、rs404566、rs16948234、rs17512483、rs17512574、rs2271007、rs11068937、rs7966814、rs6490178、rs905579、rs983421、rs1503767、rs7132650及びrs7316050からなる群より選択され、
    　ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7964173、rs11061064、rs10848174、rs7965385、rs7979388、rs7953972、rs4759749、rs4759751、rs7308461、rs1881062、rs10083153、rs729463、rs1881067、rs2695872、rs10848193、rs10848194、rs7305915、rs2398529、rs3864899、rs4412792、rs2632601、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483、rs1609985、rs10848218、rs11061198、rs7307055、rs11061209、rs10773833、rs11061222、rs7299940、rs2141182、rs1405904、rs1316893、rs4074922及びrs4388928からなる群より選択され、
    　ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs9521809、rs4773201、rs1106649、rs9521814、rs385037、rs7997619、rs912941、s1886871、rs2182271、rs912942、rs331596、rs9559844、rs331602、rs1536621、rs9521853、rs9559849、rs7999854、rs3858821、rs4771696、rs4773228、rs4773229、rs2765341、rs3742193、rs3742194、rs7323602、rs3759463、rs179356、rs330565、rs7394、rs389656、rs450514、rs445490、rs418321、rs2251314、rs2165418、rs7999702、rs9521926、rs3098728、rs9515279及びrs2582886、並びにNCBI(v36.1)110097814からなる群より選択され、
    　ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs6493469、rs12595526、rs8031702、rs17599974、rs16953045、rs10744956、rs2306335、rs6493470、rs7181201、rs11856609、rs1124769、rs17647040、rs12899586、rs12904155、rs7170455、rs7177664、rs8040954、rs17647084、rs4775916、rs1111266、rs16964077、rs1025738、rs7179084、rs7176579、rs16964113、rs10519293、rs17522553、rs12324478、rs1075681、rs2899469、rs8031580、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs16964201、rs12595627、rs8023263、rs2899473、rs700518、rs3759811、rs17703883、rs1865803、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs1062033、rs2008691、rs11636403、rs10519299、rs17647707、rs17647719、rs7167343、rs936308、rs12594203、rs999480、rs2290622、rs8031463、rs6493495、rs2445765、rs2445766、rs2445768、rs1551656、rs12441382、rs2446420、rs2124873、rs2470184、rs2470187、rs2445781、rs12595284、rs17647970、rs7174434、rs764530、rs12438104、rs16964308、rs4775942、rs16964316、rs2470172、rs2470173、rs16964319、rs10163098、rs12443092、rs2168623、rs3751586、rs2445741、rs8036694、rs2459396及びrs16964348、並びにNCBI(v36.1)49383121からなる群より選択され、
    　ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs4399573、rs12051837、rs6504736、rs7208167、rs9303589、rs1468118、rs10491154、rs17695254、rs2073864、rs9912472、rs3764798、rs17695921、rs11867674、rs886078、rs8076197、rs8076496、rs2073866、rs9901183、rs4794293、rs8064617、rs4794294、rs985758、rs4794295、rs16950363、rs2873938、rs1263962、rs1263965、rs1263988、rs1263989、rs4794298、rs4794300、rs8080331、rs11869209、rs1269480、rs1263978、rs1003290、rs1263981、rs1405191、rs1263984、rs9904076、rs4794304、rs8074185、rs6504747、rs16950512、rs7223782、rs4794305、rs16950534、rs1526182、rs1501255、rs4496207、rs1125750、rs1405187、rs767326、rs981577、rs4794307、rs202133、rs16950626、rs9896969、rs202136、rs202121、rs202120、rs203076、rs203090、rs203092、rs203093、rs203097、rs203098、rs10514990、rs203010、rs10514991、rs203022、rs6504754、rs12603762、rs169386、rs203042、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs203002、rs1005092、rs9896168、rs8065627、rs16950939、rs2907784、rs11079991、rs1393735、rs2970016、rs1875675、rs2938139、rs1354275、rs7224915、rs9893317、rs1503059、rs2970052、rs11655715、rs1155218、rs2931368、rs2931365、rs2931364、rs9908649、rs1486745、rs4605214、rs1503041、rs10514997、rs10514998、rs11079993、rs1503050、rs1503051、rs10515000、rs12949235、rs1393734、rs17678475、rs16951169、rs12150128、rs16951176、rs16951177、rs9903651、rs10515001、rs1847245、rs12150499及びrs6504764からなる群より選択され、
    　ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs8086948、rs12457951、rs11151371、rs17077389、rs1480679、rs5000099、rs1480682、rs433411、rs370944、rs395074、rs379982、rs281571、rs1444106、rs2448716、rs1562072、rs1867412、rs17077583、rs764133、rs17828615、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112、rs2448755、rs2448745、rs2440527、rs28379561、rs10503118、rs1562070、rs2448727、rs17077858、rs12605273、rs2440540、rs4127445、rs7231324、rs12964913、rs9319739、rs17077963、rs12954315、rs4127447、rs7243836、rs8085641、rs2054299、rs515540、rs519360、rs17078114、rs2613163、rs652082、rs638006、rs3911662、rs12966846、rs3845265、rs11661918、rs11151403及びrs9953435からなる群より選択され、
    　ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs1884029、rs6072606、rs2207220、rs4812571、rs4572656、rs2013923、rs4812574、rs6513762、rs6513763、rs6029950、rs2144009、rs2866941、rs6102658、rs2144011、rs3787282、rs746413、rs4812578、rs6102671、rs1126101、rs6065434、rs4810352、rs1076666、rs6029980、rs6016688、rs2076249、rs17221018、rs17221067、rs17312515、rs17221137、rs6130047、rs16986551、rs17221326、rs16986558、rs12625871、rs6016698、rs6030014、rs17221823、rs1883377、rs6016705、rs2179336、rs2143008、rs6030030、rs2206169、rs6102713、rs6093598、rs6030070、rs6030071、rs1014757、rs2143632、rs6030076、rs16986712、rs727337、rs727336、rs6030096、rs11906485、rs2867026、rs16986733、rs11698118、rs6124439、rs11696306、rs1016071、rs6030124、rs1573707、rs6016745、rs12481463、rs4812588、rs6102795、rs11697499、rs4812591、rs916327、rs1883269、rs16986850、rs1033414、rs11700137、rs6072747、rs999114、rs999113、rs6016798、rs2076082、rs6065482、rs6065484、rs6065487、rs6130145、rs230153、rs230154、rs172981、rs230155、rs6072758、rs230157、rs6124468、rs6102880、rs6130153、rs6065504、rs6065509、rs6072789、rs1033643、rs13040647、rs16987042、rs6030322、rs6072792、rs4482557、rs6130168、rs6030341、rs17747544、rs6065515、rs1883843、rs8119203、rs10854226、rs6102929、rs8121443、rs6030363、rs6102950、rs2867488、rs7360934、rs909863、rs6030370、rs6030380、rs6030381、rs9974028、rs6093705、rs6030385、rs6102967、rs2223542、rs6030395、rs6065520、rs6072814、rs2206426、rs6016864、rs6072819、rs6030407、rs6065525、rs2425520、rs2425530、rs4812631、rs4810366、rs2017914、rs3092557、rs17749109、rs4812637、rs6030442、rs6030443、rs1018407、rs6016884、rs1022819、rs733976、rs6030456、rs6093729、rs6030462、rs17749217、rs2146615、rs8119733、rs13042473、rs6103041、rs1973949、rs208256、rs208254、rs3092043、rs2077768、rs208250、rs4812645、rs6130222、rs4812655、rs6130232、rs208230、rs208229、rs6065544、rs6065545、rs6065546、rs7262282、rs7262355、rs11699742、rs8125304、rs6065547、rs4812659、rs16987493、rs208272、rs208273、rs4315585、rs208186、rs208197、rs206636、rs6030572、rs4812664、rs4812665、rs16987668、rs206148、rs206154、rs206159、rs206163、rs2208048、rs2425546、rs2425553、rs2425554、rs2425560、rs2425562、rs1106978、rs6030634、rs6016951、rs1006746、rs2425587、rs927058、rs2425593、rs2425599、rs2425610、rs16987770、rs6016963、rs6065579、rs1572929、rs6072998、rs6030670、rs947202、rs947203、rs4812681、rs6093784、rs4812683、rs10485698、rs926288、rs1569445、rs6030689、rs2867656、rs11699547、rs6030709及びrs7267873、並びにNCBI(v36.1)40130174からなる群より選択され、
    　ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs12626309、rs2834231、rs4817579、rs2834238、rs2211689、rs2834246、rs2834251、rs2834252、rs1537097、rs1892589、rs2073368、rs2409499、rs9978415、rs2268247、rs9979937、rs2834264、rs2834268、rs879261、rs2245099、rs1108000、rs9979150、rs743316、rs2300384、rs3746861、rs2834292、rs2834295、rs2040113、rs2834296、rs2834297、rs2239565、rs17655810、rs12626410、rs2834303、rs2236645、rs2834310、rs16991110、rs2070513、rs2032312、rs2032313、rs2834315、rs11088265、rs17730050及びrs2834332からなる群より選択され、
    　ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs13416802、rs2287616、rs2287613、rs3770597、rs10200158、rs6761690、rs13430236、rs3814381、rs4148765、rs10490134、rs11902639、rs10183805、rs13403114、rs3815574、rs2302698、rs6750251、rs4667590、rs4668121、rs1990702、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs11679947、rs10490132、rs2239602、rs2024481、rs741378、rs2284679、rs4287730、rs10210408、rs1548936、rs3770604、rs2075248、rs10490131、rs10169232、rs2239600、rs2284675、rs2268373、rs2268372、rs2193193、rs2268370、rs6747692、rs2300445、rs2239598、rs2239597、rs2239596、rs2239594、rs830957、rs830959、rs12988804、rs831002、rs16856748、rs11887007、rs16856759、rs830964、rs830971、rs830972、rs2247506、rs3845731、rs3770636、rs2673172、rs6713072、rs1990842、rs10199676、rs830955、rs12616998、rs12613663、rs10930354、rs4281872及びrs12052892からなる群より選択され、
    　ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs523246、rs10501136、rs836950、rs12808574、rs10836315、rs502857、rs731726、rs731727、rs967751、rs1553760、rs1396880、rs2941043、rs2941042、rs2941061、rs2956079、rs2941054、rs1509662、rs2941052、rs2915234、rs891550、rs919554、rs2915232、rs2956086、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986425、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs984690、rs3763934、rs10488801、rs2956106、rs11032927、rs2915202、rs2915201、rs2915199、rs1998912、rs2915193、rs11032937、rs2915227、rs2732557、rs10836326、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs1409716、rs2762955、rs952489、rs514182、rs1425806、rs2732528、rs2553794、rs2553793、rs678137、rs2785156、rs2553787、rs737503、rs737502、rs2162159、rs2732552、rs387619、rs10836332、rs353610、rs353605、rs2785189、rs2553822、rs11032995、rs12291631、rs353590、rs353589、rs353587、rs1559759、rs4756190、rs353581、rs7106681、rs507230、rs634096、rs2732578、rs404977、rs4756191及びrs2785180からなる群より選択され、
    　ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs7979656、rs10849918、rs2106407、rs2106406、rs12425190、rs11065783、rs2339706、rs4509829、rs7961663、rs4766526、rs4766442、rs4766443、rs12815195、rs12229654、rs756825、rs16941284、rs6489979、rs4766553、rs9783423、rs7952972、rs16941319、rs3809290、rs7962233、rs4766451、rs886126、rs2078851、rs1265566、rs2301658、rs7300082、rs7300860、rs16941414、rs7398833、rs16941437、rs10849946、rs2078863及びrs11065898からなる群より選択され、
    　ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs2332297、rs2934884、rs16955216、rs2934890、rs7225247、rs16955225、rs9303359、rs7207731、rs17683089、rs11658131、rs2958944、rs2934909、rs2934914、rs2934921、rs2958933、rs7221313、rs7210248、rs2958921、rs8079105、rs16955327、rs12949718、rs9899602、rs17745123、rs8070668、rs9910653、rs17817829、rs12936860、rs12951898、rs17817950及びrs2787501、並びにNCBI(v36.1)50344775からなる群より選択される請求項１記載の検査方法。     The polymorphic site in the region containing ELOVL5 of human chromosome 6 is the single nucleotide polymorphism international number rs222450, rs9474394, rs2816344, rs2816341, rs2518579, rs2518578, rs9367511, rs6915699, rs6930045, rs9370188, rs9382180, rs9382181, rs4486010, rs2816379, rs6939730 Rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs10948744, rs12183976, rs2562898, rs735860, rs715441, rs2057024, rs1429146, rs9463895, rs2235723, rs134660rs, 9744 , Rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517, rs9370201, rs9367529, rs12209741, rs7744451, rs6904083, rs6904376, rs9367532, rs2077433, rs9377412, 367 , Rs13212365 and rs761141
    The polymorphic site in the region containing SRBD1 of human chromosome 2 is a single nucleotide polymorphism international number rs11686431, rs7580559, rs3908093, rs2343412, rs12623996, rs7573149, rs918810, rs6721199, rs7579209, rs10194925, rs17033378, rs2343466, rs17033398, rs6737172, rs4953226 , Rs3851333, rs12473388, rs11681887, rs35608719, rs11888802, rs11678872, rs2343468, rs13003019, rs6760244, rs12471726, rs2081297, rs10460504, rs7562458, rs4953230, rs4952763, rs6719211, rs1014454, rs3753770 , Rs3770264, rs10205197, rs10427308, rs17033745, rs3770278, rs17322370, rs6736954, rs10427402, rs4476395, rs13023749, rs17033801, rs755652, rs748573, rs6708810, rs6710581, rs12712945, rs17033871, 686, rs65440840 , Rs1517001, rs1522988, rs614281, rs582213, rs650508, rs666334, rs17033965, rs556650, rs22 04204, rs3795863, rs2285024, rs505310, rs10490342, rs612717, rs10490341, rs656823, rs563601, rs609573, rs6746467, rs637889, rs10495926, rs1522986, rs1522987, rs6544843 and rs6724488,
    Polymorphic sites in the region containing ARPP-21 of human chromosome 3 are single nucleotide polymorphism international numbers rs1523048, rs1523029, rs12487524, rs1403468, rs872133, rs1523040, rs1523041, rs13069451, rs12629480, rs1357449, rs6801949, rs17033355, rs9873254, rs9839823 , Rs6794354, rs6794373, rs12637211, rs9855328, rs2037538, rs2037539, rs1523038, rs11718271, rs1608314, rs2197728, rs9311101, rs10490870, rs17033506, rs12634096, rs2359774, rs9860326, rs4678788, rs3213953, rs321393 167 Rs17280201, rs6779091, rs3772395, rs9872664, rs1963934, rs35102908, rs4678802, rs4678803, rs6550367, rs17033738, rs6801590, rs17033748, rs9865772, rs17033755, rs17228111, rs2016955, rs2016975, rs13781, rs11920715, 149 , Rs6799609, rs17033836, rs4234248, rs6770245, rs10865865, rs7615307, rs9845811, rs17033961, rs1488092 , Rs10461001 and rs17033999,
    Polymorphic sites in the region containing EPHA5 of human chromosome 4 are single nucleotide polymorphism international numbers rs371925, rs4241661, rs170654, rs1514271, rs2063419, rs13102419, rs11131589, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs4860651 , Rs11938753, rs1376417, rs10025570, rs1376416, rs2084682, rs7658065, rs9312144, rs1376412, rs17086181, rs17086185, rs6847413, rs2198103, rs12509018, rs17082122, rs6823779, rs17086224, rs1451170, rs4289492, rs8601 Rs4365778, rs7673091, rs4320185, rs4604104, rs7684022, rs4860679, rs6844942, rs12644315, rs4599467, rs6834811, rs4320186, rs4487412, rs7667410, rs4611975, rs4370201, rs4438803 and rs4608860,
    The polymorphic site in the region containing GMDS of human chromosome 6 is a single nucleotide polymorphism international number rs11966212, rs2143396, rs6911992, rs9378593, rs9392253, rs9378594, rs2050158, rs9391900, rs6596786, rs2235706, rs9378596, rs1997773, rs6926322, rs7754106, rs7750178 , Rs742520, rs2210370, rs6940618, rs349100, rs9405444, rs6932005, rs4959523, rs10484953, rs464778, rs115705, rs1013185, rs11242672, rs463641, rs4959525, rs369656, rs459162, rs127091, rs4639519, rs463264, rs775742 Rs238050, rs9378605, rs2459602, rs2438074, rs12191625, rs2438077, rs2496292, rs2496301, rs2438083, rs977674, rs977673, rs17259747, rs1437288, rs7772349, rs6596805, rs1347656, rs6925983, rs1550199, rs4159, rs4 , Rs9405137, rs9405471, rs746095, rs9378623, rs9378292, rs1711957, rs7742720, rs9378629, rs7741690, rs9328052, rs9328053 rs1922938, rs2745636, rs2816242, rs932410, rs1474721, rs9392296, rs9502950, rs6907725, rs9405484, rs4443540, rs4355648, rs9328058, rs9328059, rs2569866, rs6935712, rs6935896, rs6937266, rs16, rs16 rs2745567, rs2493160, rs2317966, rs9392305, rs9501738, rs2569839, rs9328061, rs9378300, rs2816221, rs6916316, rs2281272, rs2569824, rs9405496, rs1810496, rs2814827, rs7759035, rs9502997, rs2814811, rs231794, 937 rs9405505, rs9503015, rs9501762, rs9405506, rs12197419, rs7765344, rs7765461, rs1013303, rs3800046, rs689035, rs2318108, rs6919059, rs6928276, rs226456, rs9378314, rs1157673, rs1157675, rs9398073, rs3380 rs6596858, rs9378661, rs3823279, rs3800122, rs10484693, rs17772389, rs4959160, rs3778555, rs4463305, rs3800140, rs17134506, rs3800142, rs3800143, rs3800144, rs3800146, rs2761234, rs9405156, rs17134549, rs1408002, rs1830733, rs1830734, rs10223785, rs9405157, rs7772545, rs6596866, rs4959611, rs413269, rs4412249 rs4580917, rs6910252, rs11242733, rs9503080, rs11242735, rs476594, rs9378676, rs676015, rs2026446, rs4959631, rs17134693, rs3800156, rs11242740, rs4959635, rs3800159, rs3778557, rs3800168, rs4959643, rs234930, rs9393 690 rs3778568, rs9405550, rs17134819, rs3823287, rs1196396, rs1684153, rs9328087, rs2479003, rs2479004, rs2505678, rs2479008, rs2505674, rs7766115, rs4959648, rs4413658, rs7449538, rs9503158, rs6902156, rs6925636, rs6925636, rs6925636, rs6925636 rs13200914, rs17135028, rs4959184, rs11242770, rs9328099, rs12206851, rs6904395, rs176 09498, rs742487, rs4959185, rs9391949, rs9391950, rs6899721, rs1610416, rs3924452, rs10458144, rs9501850, rs9503199, rs4959677, rs35374935, rs2449448, rs1772982, rs1680885, rs2794569, rs2624936, rs21969936, rs12196957, rs262416 selected from the group consisting of rs2624916 and rs6899711,
    Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 are single nucleotide polymorphism international numbers rs2248373, rs2248459, rs2248462, rs2248617, rs3749946, rs2523650, rs2904776, rs2516422, rs2905747, rs9267247, rs2395034, rs3095229, rs3131631, rs2516486, rs2734573, rs3115537, rs2516478, rs2071593, rs3219183, rs13215091, rs1799964, rs1052248, rs9348876, rs2857697, rs2736172, rs1046089, rs2255741, rs760293, 8052 rs, rs3130048, 805 rs707974, rs805268, rs805267, rs9378164, rs707918, rs805292, rs2299851, rs707939, rs707937, rs480092, rs2075800, rs2763979, rs11965547, rs486416, rs6444045, rs537160, rs2072633, rs522162, rs550513, rs9296003, selected from rs406936 and rs492899
    The polymorphic site in the region containing SYTL3 of human chromosome 6 is the single nucleotide polymorphism international number rs602698, rs678116, rs649930, rs643677, rs592698, rs675053, rs612364, rs629364, rs627967, rs628203, rs2771425, rs9355655, rs10499309, rs1041566, rs12530454 , Rs7753885, rs9347236, rs6455585, rs6931414, rs10447366, rs9457403, rs9355246, rs4709219, rs4708797, rs4709226, rs4709235, rs6925091, rs3799195, rs6913912, rs894124, rs6903405, rs6901469, rs9364496, rs7756009, rs7756009 Rs3102970, rs6455604, rs3127188, rs3127194, rs3127196, rs3102966, rs3127168, rs923198, rs6924755, rs2361472, rs4569991, rs9457516, rs9456363, rs9365009, rs3923902, and rs12207795,
    Polymorphic sites in the region containing NXPH1 of human chromosome 7 are single nucleotide polymorphism international numbers rs3807826, rs7802863, rs3757521, rs3757520, rs3807823, rs1861032, rs17145870, rs7805508, rs6977682, rs3807815, rs1008038, rs3807811, rs11769978, rs3779356, rs3807 , Rs3807806, rs7455929, rs6463790, rs4620183, rs12668479, rs17147407, rs11762595, rs12702719, rs17147608, rs12154895, rs17403198, rs16873367, rs42949, rs2349188, rs6463805, rs7811039, rs10247446, rs10270530, 450, rs7795564, rs , Rs17149337, rs17404218, rs11976158, rs10244689, rs6978212, rs757704, rs2214694, rs2189904, rs765855, rs17150199, rs10261060, rs4401754, rs10266489, rs5018942, rs4556000, rs10278603, rs7787432, rs6959052, rs17150410, rs150479 , Rs1859274, rs10238726, rs6970999, rs17151821, rs7456267, rs6963180, rs10257265, rs970526 rs977458, rs13240427 and rs17154007, and is selected from the group consisting of NCBI (v36.1) 8484291,
    The polymorphic site in the region containing LHFPL3 of human chromosome 7 is the single nucleotide polymorphism international number rs41521, rs2188486, rs977641, rs17389507, rs10274138, rs17136882, rs13234807, rs7794181, rs7787988, rs7787976, rs17331134, rs1557689, rs6465984, rs7798273, rs2188 , Rs1468143, rs10953427, rs2214087, rs4730006, rs6952170, rs17137313, rs4727599, rs17137382, rs10228106, rs42181, rs4730010, rs11763758, rs17137711, rs11763095, rs6977743, rs4520098, rs10216261, rs11972050, rs12539136, rs756, rs12539136, rs756 , Rs6949801, rs9987005, rs6465994, rs6465995, rs6465995, rs1477110, rs12216618, rs10254402, rs6969323, rs9641335, rs10272959, rs3919550, rs4730030, rs10246540, rs4730031, rs2891730, rs995661, rs10487221, rs19833, rs11773248, rs1 , Rs17269890, rs4730038, rs4584085, rs10216010, rs17141284, rs17141299, rs10953450, rs6466018, rs45309 75, rs12705276, rs4283980 and rs2470965, and NCBI (v36.1) 103849313, 104068646 and 104196627,
    The polymorphic site in the region containing GLB1L3 of human chromosome 11 is the single nucleotide polymorphism international number rs11223704, rs470713, rs470935, rs641024, rs11606866, rs7131644, rs10894784, rs1031381, rs522134, rs4362160, rs473041, rs498602, rs554874, rs1144225, rs1595895 Rs1146192, rs4936229, rs1144219, rs2510356, rs553231, rs512359, rs568044, rs10894798, rs10894799, rs11223765, rs10894800, rs79940114, rs10894801, rs10791357, rs3741100, rs3741098, rs7113199, rs1866769, and rs13866768 and rs13866768
    The polymorphic site in the region containing ZNF407 of human chromosome 18 is a single nucleotide polymorphism international number rs3794941, rs17055278, rs514931, rs494721, rs17055426, rs2896769, rs12717033, rs7227977, rs10871527, rs10514139, rs17832851, rs17055756, rs14732224, rs8085262 Rs8089151 , Rs10871567, rs7242893 and rs7239800,
    The polymorphic site in the region containing PAX7 of human chromosome 1 is a single nucleotide polymorphism international number rs3000058, rs2816030, rs16862061, rs2816040, rs2816046, rs4920334, rs4920516, rs4920335, rs2816064, rs6704504, rs1934057, rs2298893, rs2743208, rs2076021, rs2076020 Rs2236826, rs2282704, rs2282699, rs624761, rs851123, rs2236817, rs685300, rs2056446, rs2841078, rs4920344, rs6669544, rs4076925, rs6603910, rs11261070, rs7539659, rs11261074, rs7411058, rs49195545, and rs66819577
    The polymorphic site in the region containing PTPRF of human chromosome 1 is a single nucleotide polymorphism international number rs2494997, rs1999674, rs2842180, rs2255632, rs2251804, rs1334973, rs6687571, rs2039528, rs2819341, rs10890251, rs2367617, rs11210864, rs2782641, rs11210871, rs10890257 Rs12058744, rs11210879, rs11210886, rs11210886, rs516790, rs641365, rs673485, rs643445, rs10789438, rs11210892, rs617521, rs660899, rs2274465, rs10789439, rs489319, rs607062, rs10789442 and rs3791035, and NCBI (v36.1) 43760103,
    The polymorphic site in the region containing 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 is a single nucleotide polymorphism international number rs2355388, rs6686200rs12122453, rs12122534, rs4950474, rs4950475, rs6593810, rs6657631, rs21327, rs517201, rs575115, rs2031481, rs2477568, rs2477569, rs692963, rs69358, rs535827, rs4950361, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs2077749, rs17159914, rs6593 rs6703187, rs10793652, rs7537483, rs7537703, rs1890038, rs3820130, rs3737845, rs17160062, rs3766525, rs4950315, rs17356240, rs10494244, rs6683839, rs10793656, rs17360443, rs3753433, rs12033407, rs3684, rs36837, rs36837 rs17360812, rs6656156, rs12759145, rs12049491, rs10793682, rs4950431, rs7539416, rs2353969, rs4504949, rs17160205, rs2353967, rs1 2728058, rs6688308, rs11589438, rs6688154, rs6678706, rs4950436, rs41989436, rs7519891, rs11240053, rs11240054, rs11240055, rs7556087, rs7518276, rs2644579, rs2353951, rs2644577, rs6674761, rs2644566, rs2803535, rs17160256, rs1258 selected from the group consisting of rs17160305,
    The polymorphic site in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1, the single nucleotide polymorphism international numbers rs10752613, rs11583896, rs16835600, rs4434872, rs4363451, rs9427232, rs4845576, rs4520447, rs4845578, rs11585416, rs4845584, rs12033835, rs11581644, rs10908557, rs6701341, rs2297898, rs12048137, rs11264875, rs2066134, rs2494663, rs6671166, rs4845600, rs19853584, rs19853584 rs1212352, rs6672010, rs6702754, rs2274988, rs2297607, rs4414034, rs6696089, rs11265607, rs6427631, rs6427658, rs6694817, rs4537545, rs4845626, rs11265618, rs10752641, rs4240872, rs4474240, rs6700290, rs12126564, rs12126564, rs12126564, rs12126564 rs1127314, rs1127313, rs2131902, rs2229857, rs3766923, rs3766922, rs12125166, rs2335230, rs7531982, rs7533471, rs11264233, rs10796927, rs2335252 rs2036627, rs6699979, rs1995662, rs6664817, rs11264249, rs6426905, rs960182, rs16836320, rs868108, rs4845390, rs10494300, rs1051614, rs6666341, rs11808053, rs883319, rs1777910, rs951240, rs9970364, rs1984285, rs9970364, rs1984285 rs4845679, rs4845681, rs12130132, rs10908448, rs4845690, rs4845406, rs10908455, rs7368345, rs10908456, rs4971079, rs4276913, rs11264339, rs3768566, rs11264345, rs7520184, rs12032720, rs11264359, rs1126411, rs9085, rs rs822508, rs1749405, rs1749409, rs572609, rs3768280, rs2275078, rs2016251, rs1475766, rs12035615, rs4661146, rs6700693, rs10908489, rs11264449, rs2253677, rs2241110, rs2853641, rs2075163, rs3 520, rs1052053, rs1067, rs1052053, rs1067 rs2287023, rs2246476, rs2248273, rs11264467, rs7522860, rs10908500, rs10494304 rs3795730, rs3762281, rs35478936, rs2274226, rs2985714, rs2842854, rs954916, rs6686886, rs11590409, rs4661040, rs7551781, rs16837376, rs11806983, rs1109751, rs11264486, rs3790458, rs1342441, rs12136856, rs1015911, rs12136856, rs10159180, rs12136 selected from the group consisting of rs879461, rs12742817, rs3795736, rs2236601, rs1046650 and rs3795737,
    The polymorphic site in the region containing FAM5B and / or ASTN1 of human chromosome 1 is a single nucleotide polymorphism international number rs7521610, rs16850728, rs227521, rs227519, rs10047146, rs10489307, rs972484, rs1402640, rs10913291, rs12094495, rs10254503, rs6425414, rs7515582 Rs10913294, rs7534953, rs10913295, rs725416, rs12090000, rs12564343, rs12031932, rs12079554, rs554454, rs6660903, rs10913300, rs760689, rs6683060, rs926319, rs6699955, rs10798508, rs2139876, rs16851037, rs17315188, rs2862 , Rs3946142, rs6658794, rs9425456, rs6672376, and rs12025407,
    The polymorphic site in the region containing PKP1 of human chromosome 1 is a single nucleotide polymorphism international number rs1122396, rs1722755, rs6413916, rs831771, rs1404401, rs831767, rs16847944, rs831765, rs16847947, rs831764, rs16847951, rs831762, rs831753, rs16847994, rs831751 Rs4915220, rs10157719, rs947379, rs12466, rs1592085, rs4915499, rs12134467, rs10158798, rs1954214, rs12046907, rs10920161, rs12117501, rs1997018, rs1880450, rs1857489, rs16848184, rs868381, rs854488, rs832169, rs832174 , Rs854502, rs1722780, rs1779293, rs854505, rs1572968, rs17425876, rs12143423, rs947377, rs10753899, rs17459837, rs6427900, rs1122481, rs2275862, rs11806184, rs2365652, rs2275860, rs947485, rs6671395, rs1256941, rs10875 And rs12090950,
    The polymorphic site in the region containing KLHL29 and / or FLJ14126 of human chromosome 2 is a single nucleotide polymorphism international number rs2577720, rs2723120, rs10495742, rs2577717, rs6720565, rs12053097, rs12613333, rs7566157, rs17045229, rs875077, rs17045238, rs2723129, rs2577698 , Rs2954818, rs12989910, rs11125011, rs6742888, rs7564616, rs2723111, rs6544822, rs893430, rs737564, rs737565, rs747344, rs6727901, rs7570872, rs17045350, rs6544861, rs6756357, rs4665214, rs10172684, rs1653748, 808646 Rs10490750, rs11677730, rs7601971, rs1653751, rs1653753, rs1368081, rs11678782, rs11678785, rs4497835, rs1653780, rs17445645, rs4665223, rs4284788, rs4665612, rs1709339, rs6544949rs17045574, rs6543966, rs4665230, rs4168 , Rs13386930, rs6721623, rs3795933, rs7560892, rs4233701, rs9261, rs7579413, rs12470949, rs124787 Selected from the group consisting of 01, rs2081302, rs12478744, rs2339853 and rs35379186,
    Polymorphic sites in the region containing THRB of human chromosome 3 are single nucleotide polymorphism international numbers rs1397878, rs6765461, rs6801153, rs1464010, rs7630879, rs6550848, rs826375, rs1667765, rs826378, rs6808673, rs2596623, rs17194828, rs1562736, rs9310730, rs2683535 , Rs7652337, rs7652444, rs2683542, rs1667739, rs1505302, rs6799431, rs17014338, rs826249, rs10510540, rs6772213, rs851719, rs6792783, rs1354605, rs866651, rs958892, rs826225, rs6550853, rs8261, 4491 417 , Rs1449872, rs9849581, rs9863517, rs9843698, rs9867989, rs1667746, rs17787319, rs1505307, rs7640580, rs12639035, rs9810037, rs9833191, rs12630454, rs3951794, rs6781111, rs1505287, rs12495379, rs44953 Rs4858617, rs4858618, rs2196427, rs10490840, rs6788339, rs6765048 and rs892941
    The polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 is a single nucleotide polymorphism international number rs13088412, rs9837084, rs744876, rs571170, rs358954, rs9833515, rs6440716, rs358967, rs1993404, rs9883677, rs2048229 Rs16863149, rs891666, rs1835668, rs6787683, rs16863204, rs16863208, rs16863229, rs3732755, rs3773614, rs1231521, rs3108727, rs3773619, rs7649855, rs16863264, rs2870518, rs3846072, rs188391, rs1882014, rs1686395, rs1881 , Rs7623356, rs1491981, rs6440735, rs3971192, rs7644001, rs16863323, rs6801273, rs9820422, rs16863336, rs1388622, rs3975404, rs10513394, rs6787801, rs9289836, rs3821663, rs7429509, rs3821664, rs1491974, rs9653954, rs965501 , Rs11709550, rs3732769, rs10935844, rs2276765, rs2276766, rs16863376, rs6440741, rs6771904, rs6772196, rs3732771, rs9864533, rs4435614, rs17204557, rs6798252, rs4680440, rs4680443, rs13088575, rs6790903, rs9289840, rs4680474, rs4541381, rs4596123 and rs7612205, and NCBI (v36.1) 152200518, 152229595, 152456055 and 152609183, selected from the group
    Polymorphic sites in the region containing SORBS2 of human chromosome 4 are single nucleotide polymorphism international numbers rs10866277, rs12645545, rs12649063, rs7437897, rs11132327, rs10866278, rs6823490, rs6843640, rs6818789, rs2101307, rs6552895, rs6552896, rs6552897, rs12498673, rs10025 , Rs2306707, rs3749579, rs6848934, rs2306703, rs11934819, rs4862558, rs4599460, rs4862559, rs6823546, rs11132334, rs5018568, rs904451, rs7677363, rs2030144, rs11132338, rs11132340, rs7669883, 132, rs1027521, rs1027521, rs1027521 , Rs10024805, rs6834923, rs6812818, rs10015164, rs11132345, rs10024359, rs10000785, rs1039235, rs2310357, rs10028428, rs4862571, rs7684943, rs10021308, rs1566347, rs12504307, rs11132355, rs10028944, rs149904, rs117307 , Rs4861686, rs1026362, rs12643549, rs2310372, rs4862588, rs10031442, rs4637445, rs194745 5, selected from the group consisting of rs2278938, rs12641600, rs4862600, rs10002339, rs7694098, rs830829, rs830838, rs830841, rs2603731
    The polymorphic site in the region containing MAST4 of human chromosome 5 is a single nucleotide polymorphism international number rs7733618, rs12514219, rs4532318, rs6861487, rs7700850, rs4587034, rs7705086, rs16895307, rs16895308, rs6890124, rs4339298, rs4613646, rs6862416, rs4532319, rs10515011 , Rs16895357, rs7732647, rs4355471, rs4554157, rs12055346, rs16895417, rs17210621, rs7706654, rs6864239, rs6896102, rs4374700, rs16895456, rs6880657, rs6863239, rs16895458, rs11953193, rs10940078, rs4446417, rs21 317 rs , Rs26384, rs7704890, rs7725568, rs30729, rs26383, rs27637, rs26382, rs9918275, rs258082, rs257699, rs257700, rs16895719, rs30731, rs16895744, rs1835136, rs36157, rs36155, rs544158, rs36144, rs36143, rs26923, rs219 , Rs192295, rs26929, rs26928, rs461702, rs460844, rs455938, rs464881, rs456775, rs154620, rs17217092, rs154618, rs10056426, rs15240 7. selected from the group consisting of rs2287929 and rs16896325, and NCBI (v36.1) 65944399,
    Polymorphic sites in the region containing GLRX and / or C5orf27 of human chromosome 5 are single nucleotide polymorphism international numbers rs34896, rs34897, rs3777220, rs3777217, rs11738579, rs3777213, rs7736948, rs6556883, rs9314160, rs6876015, rs11135436, rs17085165, rs17085170 Rs10040697, rs6884979, rs7702848, rs2080947, rs10476660, rs154454, rs147295, rs17085249, rs11741590, rs3777194, rs2270554, rs3777190, rs3777188 and rs4642392, and NCBI (v36.1) 95206085,
    The polymorphic site in the region containing EBF1 of human chromosome 5 is the single nucleotide polymorphism international number rs2913384, rs173423, rs244654, rs824854, rs824848, rs1095103, rs403334, rs10515769, rs2112262, rs33196, rs17056089, rs2042875, rs3843489, rs1541649, rs17056186 Rs2116727, rs10067813, rs7709065, rs17056205, rs1368298, rs4704963, rs10070743, rs4704967, rs10056564, rs6875710, rs17643057, rs6883655, rs891903, rs10054046, rs6556373, rs4921537, rs6556377, rs13180086, 655 , Rs9313797, rs1422672, rs17056474, rs17717829, rs10515787, rs10515786, rs10515789, rs9637861, rs7442845, rs12659540, rs3862065 and rs270661,
    The polymorphic site in the region containing DOCK2 of human chromosome 5 is a single nucleotide polymorphism international number rs4493692, rs3797712, rs3797713, rs264881, rs36101422, rs264834, rs6879467, rs6883997, rs7721990, rs7713640, rs900464, rs264846, rs2161404, rs2306560, rs3816764 Rs11134586 rs12515906 rs264844 rs2279318 rs264843 rs10063658 rs4867879 rs17736846 rs264838 rs12658902 rs2306558 rs262865 rs262840 rs262841 rs262842 rs155239 rs262848 rs262851 rs4867572 rs46885213 , Rs10076580, rs6875474, rs185532, rs17669613, rs1013193, rs17669636, rs966595, rs17669654, rs13171272, rs261612, rs13163565, rs17737323, rs155074, rs261016, rs261597, rs166368, rs261633, rs2610054, rs261625, rs1753 , Rs17670092, rs7717087, rs17737597, rs7729471, rs261039, rs261038, rs1482333, rs2291229, rs261021, rs261076, rs12515095, rs17646 198, rs17560405, rs261067, rs261060, rs261006, rs261008, rs11740615, rs11741667, rs155023, rs11742527, rs978914, rs12522080, rs2624252, rs6896240, rs6862278, rs3860755, rs259897, rs259899, rs259900, rs259902, rs259903, rs259 rs17738158, rs17561105, rs11134600, rs6893165, rs2161366, rs9313476, rs17738326, rs2287727, rs17738444, rs6884677, rs13152920, rs9790867, rs11134603, rs17738530, rs2134151, rs12055169, rs17738584, rs10104629, 994 selected from the group consisting of rs17671355, rs6555884, rs17562083, rs10516070 and rs955078;
    The polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 are single nucleotide polymorphism international numbers rs1044043, rs10484565, rs241438, rs1800454, rs241429, rs241427, rs4711312, rs2071482, rs4148882, rs12529313, rs9276815, rs20547, rs9276825, rs9276832, rs241404, rs241403, rs3101942, rs241400, rs3132132, rs151719, rs1050391, rs9378127, rs188245, rs3129305, rs176248, rs12216336, rs2894311, rs12191230, 1922391, 625 rs399604, rs365066, rs3763341, rs4713603, rs4713604, rs6936620, rs2116264, rs1367731, rs439852, rs446853, rs9296069, rs440841, rs3128952, rs3130180, rs3097662, rs3128955, rs3130588, rs9277183, rs3097669, rs9277, rs3097669, rs9277 rs2856816, rs3135021, rs1431403, rs9277542, rs3128963, rs3128965, rs3128966, rs3117229, rs2068204, rs2179920, rs2295120, rs3117242, rs3128921, rs3128923, rs9296079, rs31172 30, rs3128930, rs872956, rs9380343, rs6937034, rs6937061, rs9277637, rs3117039, rs3130233, rs3117016, rs2395351, rs3116985, rs3129249, rs3129248, rs1003979, rs2071025, rs2855459, rs439205, rs213679, rs461455, 31345814 rs211455, rs211453, rs10807124, rs411136, rs2772376, rs7747216, rs9469491, rs17627049, rs210137, rs9296095, rs210138, rs444697, rs1794681, rs9469529, rs4711332, rs12205634, rs1408711, rs1536041, rs2229637, rs1022738, rs2229637, rs102738 rs7759668, rs626156, rs498114, rs654682, rs16869412, rs10947432, rs3818532, rs9394163, rs12203688, rs4713670, rs4713671, rs622917, rs12189725, rs877187, rs4713674, rs4713677, rs943466, rs943467, rs755495, rs747475 selected from the group consisting of rs9366829, rs9394169, rs4713686 and rs10947441,
    The polymorphic site in the region containing LOC100132919 of human chromosome 6 is the single nucleotide polymorphism international number rs1338657, rs9485685, rs9377361, rs9377365, rs9377366, rs9322660, rs9322661, rs2399802, rs17063309, rs680011, rs9499111, rs9404214, rs1569366, rs1569367, rs17443301 , Rs17063399, rs6906578 and rs7740643, and NCBI (v36.1) 102984444,
    The polymorphic site in the region containing AAA1 and / or NPSR1 of human chromosome 7 is a single nucleotide polymorphism international number rs1156490, rs6462540, rs1419842, rs2392267, rs1419803, rs1419805, rs1419809, rs6977125, rs17169769, rs17169771, rs7778512, rs1419840, rs35114106 , Rs1019089, rs16878925, rs1362172, rs2392270, rs17831435, rs10951417, rs1468559, rs10486643, rs6951496, rs7458608, rs2893480, rs4723375, rs1419863, rs1419864, rs9639694, rs9639695, rs10951417, rs10215173 Rs16878959, rs12672624, rs10486649, rs2893482, rs12672538, rs10486650, rs2392274, rs2079509, rs10243426, rs2097960, rs1362173, rs1458549, rs450463, rs1023555, rs1023556, rs2530548, rs2530549, rs2530550, rs14565, rs2 , Rs323925, rs323912, rs10239860, rs1419791, rs17777040, rs17198254, rs17777663, rs17777675, rs17198982 Rs17788843, rs324978, rs324981, rs324983, rs1419780, rs325464, rs17199659, rs17789420, rs17789642, rs17170015, rs17200455, rs10263313, rs17790181 and rs11768189,
    The polymorphic sites in the region containing ELMO1 of human chromosome 7 are single nucleotide polymorphism international numbers rs10277512, rs4720221, rs7787226, rs10951500, rs10274668, rs10255208, rs2006882, rs2392472, rs756507, rs2241152, rs7785934, rs7782979, rs17170754, rs3807162, rs3734948 Rs741302, rs2041801, rs6966276, rs4723592, rs11769038, rs4723598, rs1882080, rs4723601, rs11982286, rs1986619, rs1882082, rs10268319, rs17170799, rs6957979, rs10225164, rs2293628, rs999744, rs708, rs17170826, rs708 , Rs2541103, rs2541074, rs2541075, rs2551069, rs1420421, rs6958656, rs10257460, rs12666532, rs1420422, rs17170915, rs10224438, rs7809365, rs6963276, rs6967358, rs6967403, rs10279544, rs4723619, rs1717021, 694 , Rs2717975, rs10238916, rs2723952, rs12534004, rs2893540, rs2724006, rs2717983, rs2717990, rs27 01004, rs2724007, rs2717992, rs2723996, rs9655380, rs2701003, rs27110093, rs2724003, rs2723980, rs2723990, rs2717948, rs2700992, rs6462758, rs2724014, rs2724016, rs1882079, rs2717954, rs13247953, rs2392495, rs32031, rs2392495, rs10314634 rs2052688, rs2052687, rs10282309, rs10239693, rs17261508, rs10267165, rs918979, rs7777258, rs11767227, rs1647791, rs1732001, rs17171045, rs9655382 and rs6952260, and NCBI (v36.1) 3749522,
    Polymorphic sites in the region containing TNKS of human chromosome 8 are single nucleotide polymorphism international numbers rs12680471, rs2085640, rs17149989, rs17730481, rs17663071, rs17663167, rs4841147, rs1458938, rs1458939, rs11786942, rs17674819, rs1466338, rs13253327, rs17150066, rs11777274 Rs11249921, rs17150087, rs1380104, rs11997346, rs4841156, rs6991328, rs17150131, rs7817148, rs10100760, rs17150181, rs17150185, rs17733293, rs7835349, rs7013746, rs7016636, rs3989158, rs17150211, rs4841698, rs4841174 , Rs6980831, rs12681719, rs4840427, rs4841179, rs7832096, rs4474027, rs4457339, rs12674762, rs4535743, rs1393, rs4342598, rs11780274, rs13273033, rs4841197, rs7010270, rs4841200, rs7459728, rs7461939, rs9124rs, 478 , Rs2898223, rs7820917, rs7829463, rs7000483, rs1567837, rs17734290, rs12540961, rs782973 3.
    Polymorphic sites in the region containing ANGPT1 of human chromosome 8 are single nucleotide polymorphism international numbers rs12549261, rs10955436, rs6981257, rs11774921, rs11781710, rs1954724, rs6997025, rs1892764, rs16875775, rs11778352, rs2584372, rs2246255, rs2022958, rs2022949, rs168759 Rs1010824, rs2507799, rs10505100, rs11777978, rs16875983, rs9297393, rs7009229, rs13257393, rs4077322, rs11997995, rs10505105, rs4133396, rs4133395, rs4341141, rs10505107, rs11780324, rs35143736, rs17368715, rs17225 143 , Rs1283659, rs16876122, rs1632130, rs1672143, rs16876200, rs2514867, rs1283706, rs1283703, rs11785702, rs1283663, rs1283694, rs1433192, rs1433191, rs1298936, rs1368497, rs1529747, rs2916085, rs1368494, rs384776, rs1 , Rs1433172, rs10216767, rs1583300, rs281708, rs10955457, rs10103715, rs281673, rs43989 6, rs281685, rs281696, rs2014769, rs281740 and rs190735, and NCBI (v36.1) 108394240,
    The polymorphic sites in the region containing PGM5 of human chromosome 9 are single nucleotide polymorphism international numbers rs3869296, rs7020465, rs11142449, rs11142461, rs10868851, rs13439981, rs7039076, rs265083, rs2131355, rs265087, rs265073, rs7861495, rs10869020, rs17085775, rs11795256 Rs10869034, rs1411992, rs10869043, rs12343877, rs11142941, rs869950, rs7046236 and rs9644996,
    The polymorphic site in the region containing TMC1 of human chromosome 9 is a single nucleotide polymorphism international number rs3012514, rs7846808, rs7027640, rs10781101, rs4526421, rs7853275, rs10869178, rs7864535, rs12004208, rs6560277, rs4573342, rs4132905, rs4073227, rs10121866, rs7044241 , Rs7855743, rs4373587, rs11143314, rs7047875, rs6560284, rs6560285, rs7857300, rs6560287, rs7866185, rs6560293, rs7026124, rs12346185, rs7041300, rs4307407, rs17095, rs10113863, rs7029452, rs6560297, rs9324513 Rs2487471, rs2589623, rs2793153, rs2589615, rs969205, rs1796991, rs1838487, rs2589609, rs1663756, rs12351661, rs1663763, rs13298704 and rs2501914,
    The polymorphic sites in the region containing ROR2 of human chromosome 9 are the single nucleotide polymorphism international numbers rs6479357, rs9409602, rs10991978, rs10991988, rs7867934, rs1388966, rs902923, rs902922, rs10512215, rs1532230, rs12337820, rs7029450, rs2131304, rs10992027, rs9299395 , Rs1388967, rs4073736, rs4073735, rs9409652, rs10992075, rs7031729, rs17585790, rs16907725, rs16907728, rs4372069, rs16907761, rs16907764, rs17586213, rs7039620, rs16907768, rs10992090, rs3802379, rs1195382, 474 , Rs10992124, rs7856144, rs7855417, rs6479374, rs1881385, rs16907863, rs12002851, rs1881392, rs10992137, rs7045226, rs11789730, rs16907923, rs12684524, rs7858435, rs10116326, rs16907979, rs10992161, rs6479386, 882 , Rs10820927, rs7867072, rs1954599 and rs10992207,
    Polymorphic sites in the region containing PPP6C and / or C9orf126 of human chromosome 9 are single nucleotide polymorphism international numbers rs7022663, rs7024526, rs2289631, rs10986505, rs16927802, rs12001999, rs10819019, rs6478690, rs1017530, rs3824507, rs12352758, rs4838242, rs650599 , Rs7860360, rs2113352, rs7019234, rs7867749, rs2271746, rs16927930, rs10986618, rs10986626, rs12237026, rs463774, rs420423, rs10986641, rs10513445, rs393721, rs10819043, rs10986689, rs10986703, rs10986714, rs867146, rs10986714, rs109146 , Rs10986738, rs2819624 and rs3122938,
    Polymorphic sites in the region containing GRID1 of human chromosome 10 are single nucleotide polymorphism international numbers rs2202925, rs17306253, rs10887498, rs12243608, rs1876887, rs2457451, rs2664403, rs2664394, rs1912274, rs1912322, rs744413, rs2664406, rs2664405, rs2616673, rs2175200 , Rs2175201, rs17105725, rs1912277, rs2457450, rs17105747, rs746992, rs7076174, rs4027581, rs11201743, rs4418740, rs17105793, rs12221324, rs17105805, rs7924009, rs11201759, rs11201775, rs3011700, rs2949380 , Rs2949384, rs2949385, rs2140666, rs2949386, rs1106789, rs11201804, rs17105912, rs17105916, rs2352181, rs947596, rs2352099, rs7924131, rs7923188, rs7923344, rs1418396, rs7899222, rs10788472, rs102001, rs10 , Rs7095652, rs12773130, rs12779841, rs10887544, rs11201871, rs10887549, rs10788476, rs2003111 rs7912451, rs11201882, rs2352178, rs7923926, rs7082134, rs4284352, rs6585995, rs6585996, rs5003944, rs7923310, rs884700, rs4934156, rs11201909, rs868042, rs12257526, rs12262754, rs11817682, rs12243396, rs1830156, rs1830156, rs1830156 rs2607822, rs10887563, rs10887564, rs2492738, rs1870161, rs2607839, rs1870165, rs2814340, rs1902678, rs2814349, rs1947567, rs2168725, rs1902680, rs2607833, rs1902676, rs1896527, rs65860010, rs65860010, rs65860010, rs6586004, rs6586004 rs12355013, rs7904985, rs10788500, rs10788501, rs10458771, rs2018507, rs10887608, rs4934207, rs4934208 and rs7083506,
    The polymorphic site in the region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160) is a single nucleotide polymorphism international number rs7124648, rs7128650, rs4587689, rs11039097, rs12796744, rs17197619, rs17790390, rs11039105, rs10501319, rs11039112, rs747650, rs7937410, rs17197710, rs1685404, rs2013867, rs901746, rs7118396, rs10838681, rs10501321, rs1051006, rs3816712, rs7124955, rs37310 From rs11605672, rs1534576, rs10742805, rs12419692, rs4752856, rs3817334, rs7120548, rs10838739, rs11039329, rs10742817, rs4752791, rs17788930, rs7114011, rs10838774, rs2305982, rs6485788, rs10838782, rs7924699, rs18730, rs
    The polymorphic site in the region containing OR5R1 of human chromosome 11 is the single nucleotide polymorphism international number rs1586004, rs7940239, rs10896302, rs17615246, rs10750820, rs1945245, rs3938998, rs10791979, rs1573511, rs12277883, rs7116573, rs44896287, rs1894026, rs1945 Rs1945211, rs7113069, rs11228306, rs12785840, rs10501353, rs1945203, rs585475, rs615231, rs617315, rs675991, rs7939886, rs4939052, rs621957, rs611534, rs594854, rs618594, rs634955 and rs613050,
    The polymorphic site in the region containing MS4A7 and / or MS4A14 of human chromosome 11 is a single nucleotide polymorphism international number rs1026250, rs10750931, rs7126121, rs11230241, rs10897026, rs12225299, rs10792264, rs7125753, rs11605188, rs1899571, rs11230258, rs11230261, rs7943967 , Rs4442568, rs10897047, rs2868121, rs7945665, rs10897049, rs4506675, rs10792267, rs2304935, rs2165832, rs10736703, rs4939347, rs2233244, rs950803, rs950802, rs3816270, rs2241920, rs10501383, rs193963, rs193963, rs19 , Rs2120182, rs12787520, rs4146870, rs4939364, rs1051756, rs1941032, rs17615252, rs17543397, rs8181503, rs7946021, rs4939391, rs2186919, rs2847222, rs2633277 and rs2847212, and NCBI (v36.1) 59954904,
    Polymorphic sites in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 are single nucleotide polymorphism international numbers rs565976, rs534179, rs2276443, rs532454, rs511190, rs566818, rs482458, rs1793412, rs1790149, rs1790155, rs1790154 , Rs668727, rs11600640, rs611449, rs11236449, rs661928, rs621305, rs11236452, rs7128888, rs7129014, rs688727, rs674503, rs606452, rs11236458, rs599816, rs660343, rs541993, rs601142, rs648930, rs611221, rs12574551, rs12574551, rs12574551, rs12574551, rs12574551 Rs10160335, rs12281880, rs656007, rs479592, rs589443, rs4944086, rs10751245, rs7110142, rs7947980 and rs509530, and NCBI (v36.1) 75005360,
    The polymorphic site in the region containing 11q23-24 (including PCSK7 and / or RNF214) of human chromosome 11 is a single nucleotide polymorphism international number rs17120344, rs6589597, rs10790175, rs12420127, rs10892082, rs7107152, rs1242229, rs1784042, rs2269399, rs526602, rs664971, rs11216315, rs1263499, rs17120523, rs236919, rs528508, rs593245 and rs477036, and NCBI (v36.1) 116617736,
    The polymorphic site in the region containing TAOK3 of human chromosome 12 is the single nucleotide polymorphism international number rs7297299, rs5745807, rs5745811, rs9739560, rs4767654, rs10638, rs9788041, rs11068799, rs11068803, rs10850953, rs7135008, rs11613924, rs7307331, rs9669474, rs7957463 , Rs10850956, rs2936840, rs904661, rs1726407, rs1726392, rs17440336, rs1277442, rs11068860, rs11068865, rs17512142, rs17440364, rs364823, rs418941, rs7974718, rs11068891, rs16948230, rs404566, rs16948234, rsrs124124rs, 7912 , Rs983421, rs1503767, rs7132650 and rs7316050,
    Polymorphic sites in the region containing STX2 of human chromosome 12 are single nucleotide polymorphism international numbers rs7964173, rs11061064, rs10848174, rs7965385, rs7979388, rs7953972, rs4759749, rs4759751, rs7308461, rs1881062, rs10083153, rs729463, rs1881067, rs2695872, rs10848193 , Rs10848194, rs7305915, rs2398529, rs3864899, rs4412792, rs2632601, rs1554807, rs10848205, rs2037789, rs4619189, rs2001483, rs1609985, rs10848218, rs11061198, rs7307055, rs11061209, rs10773833, rs11061222, rs7299940 Selected from the group,
    The polymorphic site in the region containing CARS2 of human chromosome 13 is the single nucleotide polymorphism international number rs9521809, rs4773201, rs1106649, rs9521814, rs385037, rs7997619, rs912941, s1886871, rs2182271, rs912942, rs331596, rs9559844, rs331602, rs1536621, rs9521853 , Rs9559849, rs7999854, rs3858821, rs4771696, rs4773228, rs4773229, rs2765341, rs3742193, rs3742194, rs7323602, rs3759463, rs179356, rs330565, rs7394, rs389656, rs450514, rs445490, rs418321, rs2251314, rs216541895, rs216541895 , As well as selected from the group consisting of NCBI (v36.1) 110097814,
    The polymorphic site in the region containing CYP19A1 of human chromosome 15 is the single nucleotide polymorphism international number rs6493469, rs12595526, rs8031702, rs17599974, rs16953045, rs10744956, rs2306335, rs6493470, rs7181201, rs11856609, rs1124769, rs17647040, rs12899586, rs12904155, rs170 , Rs7177664, rs8040954, rs17647084, rs4775916, rs1111266, rs16964077, rs1025738, rs7179084, rs7176579, rs16964113, rs10519293, rs17522553, rs12324478, rs1075681, rs2899469, rs8031580, rs8029120, rs47745883, rs4458 , Rs700518, rs3759811, rs17703883, rs1865803, rs4775936, rs10459592, rs17523270, rs10519297, rs11636686, rs11636667, rs1062033, rs2008691, rs11636403, rs10519299, rs17647707, rs17647719, rs7167343, 495, rs125943, rs , Rs2445768, rs1551656, rs12441382, rs2446420, rs2124873, rs2470184, rs2470187, rs244 5781, rs12595284, rs17647970, rs7174434, rs7645430, rs7643830, rs12438104, rs16964308, rs4775942, rs16964316, rs2470172, rs2470173, rs16964319, rs10163098, rs12443092, rs2168623, rs3751586, rs2445741, rs8036694, rs2459396, and rs169643) Selected from the group,
    The polymorphic site in the region containing CA10 of human chromosome 17 is the single nucleotide polymorphism international number rs4794268, rs4794274, rs4399573, rs12051837, rs6504736, rs7208167, rs9303589, rs1468118, rs10491154, rs17695254, rs2073864, rs9912472, rs3764798, rs17695921, rs11867674 , Rs886078, rs8076197, rs8076496, rs807396, rs2073866, rs9901183, rs4794293, rs8064617, rs4794294, rs985758, rs4794295, rs16950363, rs2873938, rs1263962, rs1263965, rs1263988, rs1263989, rs4794126, rs4791 , Rs1263984, rs9904076, rs4794304, rs8074185, rs6504747, rs16950512, rs7223782, rs4794305, rs16950534, rs1526182, rs1501255, rs4496207, rs1125750, rs1405187, rs767326, rs981577, rs4794307, 202, rs16950121, 202 , Rs203092, rs203093, rs203097, rs203098, rs10514990, rs203010, rs10514991, rs203022, rs6504754, rs12603762, rs169386, rs203042, rs7215008, rs996379, rs4794315, rs1501253, rs203050, rs203002, rs1005092, rs9896168, rs8065627, rs16950939, rs2907784, rs11079991, rs1393735, rs2970016, rs1875675, rs2938139, rs1354275, rs7221715, rs72217 rs2931368, rs2931365, rs2931364, rs9908649, rs1486745, rs4605214, rs1503041, rs10514997, rs10514998, rs11079993, rs1503050, rs1503051, rs10515000, rs12949235, rs1393734, rs17678475, rs16951169, rs12150128, rs16951105, rs16177 Selected from the group consisting of
    The polymorphic site in the region containing LOC643542 of human chromosome 18 is a single nucleotide polymorphism international number rs8086948, rs12457951, rs11151371, rs17077389, rs1480679, rs5000099, rs1480682, rs433411, rs370944, rs395074, rs379982, rs281571, rs1444106, rs2448716, rs1562072 , Rs1867412, rs17077583, rs764133, rs17828615, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112, rs2448755, rs2448745, rs2440527, rs28379561, rs10503118, rs1562070, rs2448727, rs17077858, rs1293 Is selected from the group consisting of
    The polymorphic sites in the region containing PTPRT of human chromosome 20 are single nucleotide polymorphism international numbers rs1884029, rs6072606, rs2207220, rs4812571, rs4572656, rs2013923, rs4812574, rs6513762, rs6513763, rs6029950, rs2144009, rs2866941, rs6102658, rs2144011, rs3787282 , Rs746413, rs4812578, rs6102671, rs1126101, rs6065434, rs4810352, rs1076666, rs6029980, rs6016688, rs2076249, rs17221018, rs17221067, rs17312515, rs17221137, rs6130047, rs16986551, rs17221326, rs16986558, rs126258rs, 70516 Rs2143008, rs6030030, rs2206169, rs6102713, rs6093598, rs6030070, rs6030071, rs1014757, rs2143632, rs6030076, rs16986712, rs727337, rs727336, rs6030096, rs11906485, rs2867026, rs16986733, rs11698118, rs6124439, rs169615745 , Rs4812588, rs6102795, rs11697499, rs4812591, rs916327, rs1883269, rs16986850, rs1033414, rs11700 137, rs6072747, rs999114, rs999113, rs6016798, rs2076082, rs6065482, rs6065484, rs6065487, rs6130145, rs230153, rs230154, rs172981, rs230155, rs6072758, rs230157, rs6124468, rs6102880, rs6130153, rs6065504, rs789 rs6030322, rs6072792, rs4482557, rs6130168, rs6030341, rs17747544, rs6065515, rs1883843, rs8119203, rs10854226, rs6102929, rs8121443, rs6030363, rs6102950, rs2867488, rs7360934, rs909863, rs6030370, rs6030380, 705 rs6030395, rs6065520, rs6072814, rs2206426, rs6016864, rs6072819, rs6030407, rs6065525, rs2425520, rs2425530, rs4812631, rs4810366, rs2017914, rs3092557, rs17749109, rs4812637, rs6030443, rs4 183, rs688 rs17749217, rs2146615, rs8119733, rs13042473, rs6103041, rs1973949, rs208256, rs208254, rs3092043, rs 2077768, rs208250, rs4812645, rs6130222, rs4812655, rs6130232, rs208230, rs208229, rs6065544, rs6065545, rs6065546, rs7262282, rs7262355, rs11699742, rs8125304, rs6065547, rs4812659, rs16987493, rs208272, rs208273, rs43636 rs4812664, rs4812665, rs16987668, rs206148, rs206154, rs206159, rs206163, rs2208048, rs2425546, rs2425553, rs2425554, rs2425560, rs2425562, rs1106978, rs6030634, rs6016951, rs1006746, rs2425587, rs927058, rs2425593, rs927058, rs24599 rs1572929, rs6072998, rs6030670, rs947202, rs947203, rs4812681, rs6093784, rs4812683, rs10485698, rs926288, rs1569445, rs6030689, rs2867656, rs11699547, rs6030709 and rs7267873, and NCBI (v36.1) 40130174,
    The polymorphic site in the region containing ITSN1 of human chromosome 21 is a single nucleotide polymorphism international number rs12626309, rs2834231, rs4817579, rs2834238, rs2211689, rs2834246, rs2834251, rs2834252, rs1537097, rs1892589, rs2073368, rs2409499, rs9978415, rs2268247, rs9979937 , Rs2834264, rs2834268, rs879261, rs2245099, rs1108000, rs9979150, rs743316, rs2300384, rs3746861, rs2834292, rs2834295, rs2040113, rs2834296, rs2834297, rs2239565, rs17655810, rs12626410, rs28343013, rs2236645, 705 , Rs11088265, rs17730050 and rs2834332,
    The polymorphic site in the region containing LRP2 of human chromosome 2 is a single nucleotide polymorphism international number rs13416802, rs2287616, rs2287613, rs3770597, rs10200158, rs6761690, rs13430236, rs3814381, rs4148765, rs10490134, rs11902639, rs10183805, rs13403114, rs3815574, rs2302698 , Rs6750251, rs4667590, rs4668121, rs1990702, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs11679947, rs10490132, rs2239602, rs2024481, rs741378, rs2284679, rs4287730, rs10210, rs10 Rs2268373, rs2268372, rs2193193, rs2268370, rs6747692, rs2300445, rs2239598, rs2239597, rs2239596, rs2239594, rs830957, rs830959, rs12988804, rs831002, rs16856748, rs11887007, rs16856759, rs830964, rs830971, rs8303 , Rs1990842, rs10199676, rs830955, rs12616998, rs12613663, rs10930354, rs4281872 and rs12052892 More is selected,
    The polymorphic site in the region containing APIP and / or PDHX of human chromosome 11 is a single nucleotide polymorphism international number rs523246, rs10501136, rs836950, rs12808574, rs10836315, rs502857, rs731726, rs731727, rs967751, rs1553760, rs1396880, rs2941043, rs2941042 , Rs2941061, rs2956079, rs2941054, rs1509662, rs2941052, rs2915234, rs891550, rs919554, rs2915232, rs2956086, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs3751078, 694, rs220 , Rs2986429, rs2915217, rs7111607, rs2915214, rs984690, rs3763934, rs10488801, rs2956106, rs11032927, rs2915202, rs2915201, rs2915199, rs1998912, rs2915193, rs11032937, rs2915227, rs1082 263, rs8066703, rs8063 , Rs952489, rs514182, rs1425806, rs2732528, rs2553794, rs2553793, rs678137, rs2785156, rs2553787, rs737503, rs737502 rs2162159, rs2732552, rs387619, rs10836332, rs353610, rs353605, rs2785189, rs2553822, rs11032995, rs12291631, rs353590, rs353589, rs353587, rs1559759, rs4756190, rs353581, rs7106681, rs507230, rs634096, rs2732578, 7851 And
    Polymorphic sites in the region containing CUX2 of human chromosome 12 are single nucleotide polymorphism international numbers rs7979656, rs10849918, rs2106407, rs2106406, rs12425190, rs11065783, rs2339706, rs4509829, rs7961663, rs4766526, rs4766442, rs4766443, rs12815195, rs12229654, rs756825 Rs16941284, rs6489979, rs4766553, rs9783423, rs7952972, rs16941319, rs3809290, rs7962233, rs4766451, rs886126, rs2078851, rs1265566, rs2301658, rs7300082, rs7300860, rs16941414, rs16939837, rs1693
    The polymorphic site in the region containing TOM1L1 of human chromosome 17 is a single nucleotide polymorphism international number rs2332297, rs2934884, rs16955216, rs2934890, rs7225247, rs16955225, rs9303359, rs7207731, rs17683089, rs11658131, rs2958944, rs2934909, rs2934914, rs2934921, rs93358 Rs7221313, rs7210248, rs2958921, rs8079105, rs16955327, rs12949718, rs9899602, rs17745123, rs8070668, rs9910653, rs17817829, rs12936860, rs12951898, rs17817950 and rs2787501, and NCBI (v36.1) 50344775 Inspection method.
  3. 正常眼圧緑内障患者と健常者間での有意差をｐ値で表したとき、多型部位のｐ値が0.05未満を示す請求項１又は２記載の検査方法。 The examination method according to claim 1 or 2, wherein when a significant difference between a normal-tension glaucoma patient and a healthy person is expressed by a p-value, the p-value of the polymorphic site is less than 0.05.
  4. ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs2562898、rs735860、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201l及びrs9367529からなる群より選択され、
    　ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs2343466、rs11888802、rs2343468、rs12471726、rs2081297、rs10460504、rs6719211、rs3213787、rs4455206、rs3755076、rs3770264、rs10205197、rs17033745、rs17322370、rs17033801、rs748573、rs6708810、rs6710581、rs17033871、rs3755082、rs11884064及びrs556650からなる群より選択され、
    　ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs12487524、rs872133、rs2197728、rs2359774、rs6799641、rs4678789、rs11129660、rs11129662、rs6779091、rs3772395、rs17228111、rs735353、rs11920715、rs1455489、rs4678509、rs10510667、rs6799649及びrs4234248からなる群より選択され、
    　ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs11938753、rs7658065、rs17082122、rs4289492、rs9991256、rs7660334及びrs4604104からなる群より選択され、
    　ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs2438083、rs7744559、rs9378292、rs2569866、rs11242704、rs2816286、rs2816287、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs1810496、rs12197419、rs2318108、rs6919059、rs17134506、rs3800142、rs3800146、rs10223785、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs9392353、rs11242730、rs4580917、rs11242733、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs11242740、rs3778557、rs234930、rs234915、rs234914、rs3800184、rs234932、rs3778568、rs9405550、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs7449538、rs6902556、rs6925653及びrs6904395からなる群より選択され、
    　ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2077102、rs805301、rs2242655、rs707918、rs805292、rs2299851、rs707939、rs480092、rs2075800、rs2763979及びrs11965547からなる群より選択され、
    　ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs6455585、rs6931414、rs6925091、rs6913912、rs894124、rs6455601及びrs3123094からなる群より選択され、
    　ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs10246412、rs17404198、rs17149337、rs17404218、rs11976158、rs6978212、rs10261060、rs4401754、rs10278603、rs7787432、rs10237485及びNCBI(v36.1)8484291からなる群より選択され、
    　ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs7794181、rs11763758、rs756669、rs4730038、rs4584085、rs17141284、rs17141299及びNCBI(v36.1)104196627からなる群より選択され、
    　ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs1146192、rs1144219、rs2510356及びrs1866768からなる群より選択され、
    　ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs514931、rs10871527及びrs17832851からなる群より選択され、
    　ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs2298893、rs685300及びrs2056446からなる群より選択され、
    　ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs6687571、rs2039528、rs10890251、rs10890257、rs12058744、rs11210879、rs10789438、rs11210892、rs617521及びrs10789439からなる群より選択され、
    　ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200、rs12122453、rs12122534、rs517201、rs2031481、rs2477568、rs2477569、rs535827、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs17159914、rs6593745、rs6670503、rs6703187、rs10793652、rs7537483、rs7537703、rs3820130、rs3737845、rs4950315、rs10494244、rs6683839、rs10793656、rs17360443、rs12033407、rs10793661、rs10736837、rs10900336、rs4950409、rs10793682、rs11240055、rs17160256、rs17160264及びrs17160305からなる群より選択され、
    　ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs11265310、rs16836320、rs868108、rs4845390、rs1984285、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822508、rs1749405、rs954916及びrs11590409からなる群より選択され、
    　ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs227521、rs227519、rs10047146、rs10489307、rs1402640、rs10913291、rs10798503、rs725416、rs554454、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs17315298、rs2861972及びrs6672376からなる群より選択され、
    　ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1404401、rs16847944、rs1572968、rs12143423、rs6427900及びrs2275860からなる群より選択され、
    　ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs12613333、rs2723129、rs1465677、rs1864807、rs1864808、rs497973及びrs3806510からなる群より選択され、
    　ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6808673、rs17194828、rs9310730、rs7652444、rs4858594、rs17787319、rs1505307、rs7640580、rs9833191、rs3951794及びrs5014281からなる群より選択され、
    　ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs1993404、rs16863149、rs16863204、rs16863208、rs3732755、rs3773614、rs9820422、rs1388622及びrs4680474からなる群より選択され、
    　ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10015164、rs10024359、rs11940307、rs2648120、rs2648117、rs4861686、rs4637445、rs2278938、rs12641600、rs4862600及びrs10002339からなる群より選択され、
    　ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs16895719、rs16895744、rs37568、rs16896071、rs39664、rs469300、rs467845及びNCBI(v36.1)65944399からなる群より選択され、
    　ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs6876015、rs11135436、rs6884979、rs7702848、rs2080947及びNCBI(v36.1)95206085からなる群より選択され、
    　ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs1541649、rs2116727、rs10067813、rs7709065、rs10070743、rs10056564、rs6556373、rs4921537、rs1544754、rs17056426、rs1363561、rs1422672、rs10515787及びrs10515786からなる群より選択され、
    　ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs7729471、rs261039、rs2291229、rs17646198、rs17560405、rs261006、rs155023、rs259900、rs13152920、rs11134603及びrs10462995からなる群より選択され、
    　ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs10484565、rs9276825、rs188245、rs6457710、rs455567、rs211453、rs2772376、rs9469491、rs9296095、rs498114、rs654682、rs10947432、rs943466、rs755495、rs747692、rs943475、rs6929696、rs3828783及びrs9366829からなる群より選択され、
    　ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs9377361、rs9322660、rs9322661、rs2399802、rs680011、rs9499111、rs1569366、rs1569367及びrs6906578からなる群より選択され、
    　ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs12673387、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs10486649、rs12672538、rs450463、rs2530548、rs2530549、rs2530550、rs1458544、rs323925及びrs323912からなる群より選択され、
    　ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs4720221、rs2392472、rs17170754、rs3807162及びrs11982286からなる群より選択され、
    　ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs1466338、rs6991328、rs17150131、rs7817148、rs7016636、rs6985564、rs4840426、rs7832096、rs13273033、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs7820917、rs7829463、rs17734290、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996及びrs7828229からなる群より選択され、
    　ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs16876200、rs2514867、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191及びrs10216767からなる群より選択され、
    　ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs7020465、rs10868851、rs7039076、rs2131355、rs265073、rs7861495、rs10869020、rs11795256、rs10869034、rs1411992、rs10869043及びrs12343877からなる群より選択され、
    　ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs7027640、rs12004208、rs6560277、rs7044241、rs4373587、rs11143314、rs7047875、rs7866185、rs7026124、rs12346185、rs7041300、rs4307407、rs10113863、rs7029452、rs7045535、rs13285932、rs10521449、rs1037031及びrs2487471からなる群より選択され、
    　ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs10119449、rs7022147、rs7856144、rs6479374、rs1881385及びrs7045226からなる群より選択され、
    　ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs1017530、rs7860360、rs2113352、rs7019234、rs2271746、rs10986618、rs10986626、rs10513445、rs10986703及びrs10986738からなる群より選択され、
    　ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs11201743、rs17105793、rs17105805、rs11201775、rs10887549、rs10788476及びrs4284352からなる群より選択され、
    　ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs11039112、rs747650、rs1685404、rs11570094、rs11039212、rs4992357、rs11605672、rs10742805、rs12419692、rs4752856、rs3817334、rs4752791、rs17788930、rs2305982、rs6485788、rs7924699及びrs1872167からなる群より選択され、
    　ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs7113069、rs11228306、rs10501353、rs1945203、rs615231、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594及びrs634955からなる群より選択され、
    　ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs4939347、rs2233244、rs3816270、rs2241920、rs10501383、s10897056及びrs4939352からなる群より選択され、
    　ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs482458、rs661928、rs7128888、rs7129014、rs688727、rs12574551、rs17134231、rs12282340、rs10160335及びrs12281880からなる群より選択され、
    　ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs664971、rs17120523及びrs528508からなる群より選択され、
    　ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs10850953、rs1726392、rs17440336、rs17512142、rs17440364、rs16948230、rs16948234、rs17512483及びrs17512574からなる群より選択され、
    　ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7305915、rs3864899、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483及びrs1405904からなる群より選択され、
    　ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs4773201、rs450514、rs445490、rs418321及びrs2251314からなる群より選択され、
    　ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs12595526、rs1124769、rs17647040、rs7170455、rs7177664、rs8040954、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs8023263、rs700518、rs3759811、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs11636403、rs10519299、rs2445765、rs12441382、rs2446420、rs2445781、rs7174434、rs12438104、rs4775942及びrs16964316からなる群より選択され、
    　ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs12051837、rs6504736、rs4496207、rs9896969、rs203076、rs203090、rs203092、rs12603762、rs169386、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs1005092及びrs9896168からなる群より選択され、
    　ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs433411、rs370944、rs395074、rs281571、rs2448716、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112及びrs17077963からなる群より選択され、
    　ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs4572656、rs16986733、rs6016745、rs6016798、rs6065487、rs6130145、rs230153、rs230155、rs6072758、rs8119203、rs6030395、rs2425530、rs4812637、rs6030456、rs927058、rs2425593、rs16987770、rs6065579、rs6072998、rs6030670、rs947202、rs947203及びrs6093784からなる群より選択され、
    　ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs2834268、rs9979150、rs2300384、rs3746861、rs2834292、rs2834303及びrs2236645からなる群より選択され、
    　ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs4668121、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs2239602、rs741378、rs10210408、rs1548936、rs3770604、rs2075248、rs10169232、rs2239600、rs2284675、rs2268370、rs6747692、rs2239596、rs830957、rs830959、rs12988804、rs831002、rs1990842及びrs10199676からなる群より選択され、
    　ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs836950、rs12808574、rs10836315、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs3763934、rs10488801、rs2956106、rs11032927、rs1998912、rs2915193、rs11032937、rs2915227、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs952489及びrs353589からなる群より選択され、
    　ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs756825、rs4766553、rs3809290、rs4766451、rs886126、rs1265566、rs2301658及びrs7300082からなる群より選択され、
    　ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs17817829、rs12951898、rs17817950及びNCBI(v36.1)50344775からなる群より選択される請求項３記載の検査方法。     The polymorphic site in the region containing ELOVL5 of human chromosome 6 is the single nucleotide polymorphism international number rs2817088, rs2817090, rs2816372, rs2562895, rs2816364, rs2562893, rs2817101, rs2816362, rs2816356, rs2562898, rs735860, rs2057024, rs1429146, rs9463895, rs2235723 , Rs1346603, rs9474476, rs2294867, rs9349660, rs974323, rs6909592, rs9367520, rs9395854, rs209485, rs9395856, rs7747926, rs7738788, rs209500, rs9357760, rs9370196, rs209512, rs209517, rs9370201l, and rs9367529
    The polymorphic sites in the region containing SRBD1 of human chromosome 2 are single nucleotide polymorphism international numbers rs2343466, rs11888802, rs2343468, rs12471726, rs2081297, rs10460504, rs6719211, rs3213787, rs4455206, rs3755076, rs3770264, rs10205197, rs17033745, rs17322370, rs17033801 Rs748573, rs6708810, rs6710581, rs17033871, rs3755082, rs11884064 and rs556650,
    The polymorphic sites in the region containing ARPP-21 of human chromosome 3 are single nucleotide polymorphism international numbers rs12487524, rs872133, rs2197728, rs2359774, rs6799641, rs4678789, rs11129660, rs11129662, rs6779091, rs3772395, rs17228111, rs735353, rs11920715, rs1455489 , Rs4678509, rs10510667, rs6799649 and rs4234248,
    Polymorphic sites in the region containing EPHA5 of human chromosome 4 are single nucleotide polymorphism international numbers rs371925, rs4241661, rs2167320, rs1159057, rs12501311, rs17086016, rs961489, rs7684130, rs3749526, rs11938753, rs7658065, rs17082122, rs4289492, rs9991256, rs7660334 And rs4604104,
    The polymorphic sites in the region containing GMDS of human chromosome 6 are single nucleotide polymorphism international numbers rs2438083, rs7744559, rs9378292, rs2569866, rs11242704, rs2816286, rs2816287, rs2317965, rs2873591, rs2569835, rs2745567, rs2493160, rs1810496, rs12197419, rs2318108 Rs6919059, rs17134506, rs3800142, rs3800146, rs10223785, rs6596866, rs4959621, rs4412249, rs4367413, rs11242729, rs6925298, rs9392353, rs11242730, rs4580917, rs11242733, rs11242735, rs476594, rs9378676, rs676015, rs264 Rs234914, rs3800184, rs234932, rs3778568, rs9405550, rs3823287, rs1196396, rs1684153, rs9328087, rs2479003, rs2479004, rs2505678, rs2479008, rs2505674, rs7766115, rs4959648, rs69049538, rs6902556, rs6925653 and rs69025653
    Polymorphic sites in the region containing 6p21.3 (including HSPA1B) of human chromosome 6 are represented by single nucleotide polymorphism international numbers rs2077102, rs805301, rs2242655, rs707918, rs805292, rs2299851, rs707939, rs480092, rs2075800, rs2763979 and rs11965547 Selected from the group consisting of
    The polymorphic site in the region containing SYTL3 of human chromosome 6 is selected from the group consisting of single nucleotide polymorphism international numbers rs6455585, rs6931414, rs6925091, rs6913912, rs894124, rs6455601 and rs3123094;
    The polymorphic sites in the region containing NXPH1 of human chromosome 7 are single nucleotide polymorphism international numbers rs10246412, rs17404198, rs17149337, rs17404218, rs11976158, rs6978212, rs10261060, rs4401754, rs10278603, rs7787432, rs10237485 and NCBI (v36.1) 8484291 Selected from the group consisting of
    A polymorphic site in the region containing LHFPL3 of human chromosome 7 is selected from the group consisting of single nucleotide polymorphism international numbers rs7794181, rs11763758, rs756669, rs4730038, rs4584085, rs17141284, rs17141299 and NCBI (v36.1) 104196627;
    A polymorphic site in the region containing GLB1L3 of human chromosome 11 is selected from the group consisting of single nucleotide polymorphism international numbers rs11223704, rs1146192, rs1144219, rs2510356 and rs1866768;
    The polymorphic site in the region containing ZNF407 of human chromosome 18 is selected from the group consisting of single nucleotide polymorphism international numbers rs514931, rs10871527 and rs17832851,
    The polymorphic site in the region containing PAX7 of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs2298893, rs685300 and rs2056446,
    The polymorphic site in the region containing PTPRF of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs6687571, rs2039528, rs10890251, rs10890257, rs12058744, rs11210879, rs10789438, rs11210892, rs617521 and rs10789439,
    The polymorphic site in the region including 1q12-q21.1 (including CHD1L and / or FMO5) of human chromosome 1 is a single nucleotide polymorphism international number rs2355388, rs6686200, rs12122453, rs12122534, rs517201, rs2031481, rs2477568, rs2477569, rs535827, rs6593732, rs17359526, rs6693631, rs11811023, rs4950371, rs2304893, rs6593739, rs7525703, rs2883434, rs17159914, rs6593745, rs6670503, rs6703187, rs10793652, rs7537483, rs7537703, rs3820134, rs3153 selected from the group consisting of rs10793661, rs10736837, rs10900336, rs4950409, rs10793682, rs11240055, rs17160256, rs17160264 and rs17160305,
    The polymorphic site in the region containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3) of human chromosome 1 is a single nucleotide polymorphism international number rs11265310, rs16836320, rs868108, rs4845390, rs1984285, rs11264339, rs3768566, rs11264345, rs7520184, rs12032720, rs11264359, rs11264363, rs5005770, rs1325908, rs11264375, rs475550, rs821551, rs822490, rs822508, rs1749405, rs954916 and rs11590409,
    The polymorphic site in the region containing FAM5B and / or ASTN1 of human chromosome 1 is the single nucleotide polymorphism international number rs227521, rs227519, rs10047146, rs10489307, rs1402640, rs10913291, rs10798503, rs725416, rs554454, rs10913300, rs760689, rs6683060, rs926319 Rs6699955, rs10798508, rs2139876, rs17315298, rs2861972 and rs6672376,
    The polymorphic site in the region containing PKP1 of human chromosome 1 is selected from the group consisting of single nucleotide polymorphism international numbers rs1404401, rs16847944, rs1572968, rs12143423, rs6427900 and rs2275860,
    The polymorphic site in the region containing KLHL29 and / or FLJ14126 of human chromosome 2 is selected from the group consisting of single nucleotide polymorphism international numbers rs12613333, rs2723129, rs1465677, rs1864807, rs1864808, rs497973 and rs3806510;
    The polymorphic site in the region containing THRB of human chromosome 3 is selected from the group consisting of single nucleotide polymorphism international numbers rs1397878, rs6808673, rs17194828, rs9310730, rs7652444, rs4858594, rs17787319, rs1505307, rs7640580, rs9833191, rs3951794 and rs5014281 ,
    The polymorphic site in the region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3 is from the group consisting of single nucleotide polymorphism international numbers rs1993404, rs16863149, rs16863204, rs16863208, rs3732755, rs3773614, rs9820422, rs1388622 and rs4680474 Selected
    The polymorphic site in the region containing SORBS2 of human chromosome 4 is selected from the group consisting of single nucleotide polymorphism international numbers rs10015164, rs10024359, rs11940307, rs2648120, rs2648117, rs4861686, rs4637445, rs2278938, rs12641600, rs4862600 and rs10002339,
    A polymorphic site in the region containing MAST4 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs16895719, rs16895744, rs37568, rs16896071, rs39664, rs469300, rs467845 and NCBI (v36.1) 65944399;
    The polymorphic site in the region containing GLRX and / or C5orf27 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs6876015, rs11135436, rs6884979, rs7702848, rs2080947 and NCBI (v36.1) 95206085,
    The polymorphic site in the region containing EBF1 of human chromosome 5 consists of single nucleotide polymorphism international numbers rs1541649, rs2116727, rs10067813, rs7709065, rs10070743, rs10056564, rs6556373, rs4921537, rs1544754, rs17056426, rs1363561, rs1422672, rs10515787 and rs10515786 Selected from the group,
    The polymorphic site in the region containing DOCK2 of human chromosome 5 is selected from the group consisting of single nucleotide polymorphism international numbers rs7729471, rs261039, rs2291229, rs17646198, rs17560405, rs261006, rs155023, rs259900, rs13152920, rs11134603 and rs10462995,
    The polymorphic sites in the region containing 6p21.31-p21.3 (including HLA-DPA1) of human chromosome 6 are single nucleotide polymorphism international numbers rs10484565, rs9276825, rs188245, rs6457710, rs455567, rs211453, rs2772376, rs9469491, selected from the group consisting of rs9296095, rs498114, rs654682, rs10947432, rs943466, rs755495, rs747692, rs943475, rs6929696, rs3828783 and rs9366829,
    The polymorphic site in the region containing LOC100132919 of human chromosome 6 is selected from the group consisting of single nucleotide polymorphism international numbers rs9377361, rs9322660, rs9322661, rs2399802, rs680011, rs9499111, rs1569366, rs1569367 and rs6906578,
    Polymorphic sites in the region containing AAA1 and / or NPSR1 of human chromosome 7 are single nucleotide polymorphism international numbers rs12673387, rs6950303, rs1034876, rs17169864, rs17169865, rs16878959, rs10486649, rs12672538, rs450463, rs2530548, rs2530549, rs2530550, rs1458544 , Rs323925 and rs323912,
    The polymorphic site in the region containing ELMO1 of human chromosome 7 is selected from the group consisting of single nucleotide polymorphism international numbers rs4720221, rs2392472, rs17170754, rs3807162 and rs11982286;
    The polymorphic sites in the region containing TNKS of human chromosome 8 are single nucleotide polymorphism international numbers rs1466338, rs6991328, rs17150131, rs7817148, rs7016636, rs6985564, rs4840426, rs7832096, rs13273033, rs4841200, rs7459728, rs7461939, rs9644708, rs12545912, rs4840437 Rs7004915, rs7820917, rs7829463, rs17734290, rs13270146, rs6601389, rs6601390, rs10098618, rs12056944, rs12543996 and rs7828229,
    The polymorphic site in the region containing ANGPT1 of human chromosome 8 is selected from the group consisting of single nucleotide polymorphism international numbers rs16876200, rs2514867, rs11785702, rs1283663, rs1283694, rs1433192, rs1433191, and rs10216767,
    The polymorphic site in the region containing PGM5 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs7020465, rs10868851, rs7039076, rs2131355, rs265073, rs7861495, rs10869020, rs11795256, rs10869034, rs1411992, rs10869043 and rs12343877 ,
    The polymorphic site in the region containing TMC1 of human chromosome 9 is a single nucleotide polymorphism international number rs7027640, rs12004208, rs6560277, rs7044241, rs4373587, rs11143314, rs7047875, rs7866185, rs7026124, rs12346185, rs7041300, rs4307407, rs10113863, rs7029452, rs7045535 Selected from the group consisting of rs13285932, rs10521449, rs1037031 and rs2487471,
    The polymorphic site in the region containing ROR2 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs10119449, rs7022147, rs7856144, rs6479374, rs1881385 and rs7045226,
    The polymorphic site in the region containing PPP6C and / or C9orf126 of human chromosome 9 is selected from the group consisting of single nucleotide polymorphism international numbers rs1017530, rs7860360, rs2113352, rs7019234, rs2271746, rs10986618, rs10986626, rs10513445, rs10986703, and rs10986738 ,
    The polymorphic site in the region containing GRID1 of human chromosome 10 is selected from the group consisting of single nucleotide polymorphism international numbers rs2202925, rs11201743, rs17105793, rs17105805, rs11201775, rs10887549, rs10788476 and rs4284352.
    The polymorphic site in the region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160) is a single nucleotide polymorphism international number rs11039112, rs747650, rs1685404, rs11570094, rs11039212, rs4992357, rs11605672, rs10742805, rs12419692, rs4752856, rs3817334, rs4752791, rs17788930, rs2305982, rs6485788, rs7924699 and rs1872167,
    The polymorphic site in the region containing OR5R1 of human chromosome 11 is the single nucleotide polymorphism international number rs1586004, rs7940239, rs10791979, rs1573511, rs12277883, rs7116573, rs10896333, rs4420287, rs18994026, rs7113069, rs11228306, rs10501353, rs1945203, rs615231, rs7939886 Selected from the group consisting of rs4939052, rs621957, rs611534, rs594854, rs618594 and rs634955,
    The polymorphic site in the region containing human chromosome 11 MS4A7 and / or MS4A14 is selected from the group consisting of single nucleotide polymorphism international numbers rs4939347, rs2233244, rs3816270, rs2241920, rs10501383, s10897056 and rs4939352.
    The polymorphic site in the region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11 consists of the single nucleotide polymorphism international numbers rs482458, rs661928, rs7128888, rs7129014, rs688727, rs12574551, rs17134231, rs12282340, rs10160335 and rs12281880 Selected from the group,
    The polymorphic site in the region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214) is selected from the group consisting of single nucleotide polymorphism international numbers rs664971, rs17120523 and rs528508
    The polymorphic site in the region containing TAOK3 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs10850953, rs1726392, rs17440336, rs17512142, rs17440364, rs16948230, rs16948234, rs17512483 and rs17512574,
    The polymorphic site in the region containing STX2 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs7305915, rs3864899, rs1554807, rs10848205, rs2037789, rs4619189, rs2001483 and rs1405904,
    The polymorphic site in the region containing CARS2 of human chromosome 13 is selected from the group consisting of single nucleotide polymorphism international numbers rs4773201, rs450514, rs445490, rs418321 and rs2251314;
    The polymorphic site in the region containing CYP19A1 of human chromosome 15 is a single nucleotide polymorphism international number rs12595526, rs1124769, rs17647040, rs7170455, rs7177664, rs8040954, rs8029120, rs4774583, rs2289105, rs8034835, rs6493489, rs8023263, rs700518, rs3759811, rs4775 , Rs10459592, rs17523270, rs10519297, rs11636686, rs11636667, rs11636403, rs10519299, rs2445765, rs12441382, rs2446420, rs2445781, rs7174434, rs12438104, rs4775942 and rs16964316,
    Polymorphic sites in the region containing CA10 of human chromosome 17 are single nucleotide polymorphism international numbers rs4794268, rs4794274, rs12051837, rs6504736, rs4496207, rs9896969, rs203076, rs203090, rs203092, rs12603762, rs169386, rs7215008, rs996379, rs4794315, rs1501253 , Rs203050, rs1005092, and rs9896168,
    The polymorphic site in the region containing LOC643542 of human chromosome 18 is selected from the group consisting of single nucleotide polymorphism international numbers rs433411, rs370944, rs395074, rs281571, rs2448716, rs2440515, rs10503119, rs2318439, rs12607172, rs9319737, rs1444112 and rs17077963 ,
    The polymorphic sites in the region containing PTPRT of human chromosome 20 are single nucleotide polymorphism international numbers rs4572656, rs16986733, rs6016745, rs6016798, rs6065487, rs6130145, rs230153, rs230155, rs6072758, rs8119203, rs6030395, rs2425530, rs4812637, rs6030456, rs927058 Rs2425593, rs16987770, rs6065579, rs6072998, rs6030670, rs947202, rs947203 and rs6093784,
    A polymorphic site in the region containing ITSN1 of human chromosome 21 is selected from the group consisting of single nucleotide polymorphism international numbers rs2834268, rs9979150, rs2300384, rs3746861, rs2834292, rs2834303 and rs2236645;
    The polymorphic site in the region containing LRP2 of human chromosome 2 is the single nucleotide polymorphism international number rs4668121, rs6746604, rs990627, rs990626, rs2268380, rs6733122, rs2284681, rs2239602, rs741378, rs10210408, rs1548936, rs3770604, rs2075248, rs10169232, rs2239600 Rs2284675, rs2268370, rs6747692, rs2239596, rs830957, rs830959, rs12988804, rs831002, rs1990842 and rs10199676,
    The polymorphic site in the region containing APIP and / or PDHX of human chromosome 11 is a single nucleotide polymorphism international number rs836950, rs12808574, rs10836315, rs1998603, rs2985390, rs1571134, rs1571135, rs2915224, rs1430855, rs2985389, rs3751078, rs2915223, rs2915220 Rs2986427, rs1326940, rs1326941, rs1326942, rs2986429, rs2915217, rs7111607, rs2915214, rs3763934, rs10488801, rs2956106, rs11032927, rs1998912, rs2915193, rs11032937, rs2915227, rs2767038, rs3488353, rs2 Selected
    The polymorphic site in the region containing CUX2 of human chromosome 12 is selected from the group consisting of single nucleotide polymorphism international numbers rs756825, rs4766553, rs3809290, rs4766451, rs886126, rs1265566, rs2301658 and rs7300082;
    The test method according to claim 3, wherein the polymorphic site in the region containing TOM1L1 of human chromosome 17 is selected from the group consisting of single nucleotide polymorphism international numbers rs17817829, rs12951898, rs17817950 and NCBI (v36.1) 50344775.
  5. 正常眼圧緑内障の検査をするための試薬であって、下記の(a)及び(b)の成分からなる群より選択される少なくとも１つの成分を含む前記試薬。
    (a) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域を増幅することができるプライマー
    (b) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む領域にハイブリダイズすることができるプローブ     A reagent for examining normal-tension glaucoma, which comprises at least one component selected from the group consisting of the following components (a) and (b):
    (a) the region of human chromosome 6 containing ELOVL5, the region of human chromosome 2 containing SRBD1, the region of human chromosome 3 containing ARPP-21, the region of human chromosome 4 containing EPHA5, the human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 and A region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6. 3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human chromosome 8 TNKS-containing region, human chromosome 8 ANGPT1 region, human chromosome 9 PGM5 region, human chromosome 9 TMC1 region, human chromosome 9 ROR2 region, human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing area, human number Region containing two chromosomal CUX2, and primers which can amplify a region comprising at least one polymorphic sites in at least one region selected from the group consisting of a region including a TOM1L1 human chromosome 17
    (b) Human chromosome 6 region containing ELOVL5, human chromosome 2 region containing SRBD1, human chromosome 3 region containing ARPP-21, human chromosome 4 region containing EPHA5, human chromosome 6 A region containing GMDS, a region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, and a LHFPL3 of human chromosome 7 Region, region containing GLB1L3 of human chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21 of human chromosome 1 .1 (including CHD1L and / or FMO5), human chromosome 1 containing 1q21.2-q21.3 (including FDPS and / or ASH1L and / or KCNN3), human chromosome 1 FAM5B And / or a region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2 and A region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, A region containing MAST4, a region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21 of human chromosome 6. 3 (including HLA-DPA1), human chromosome 6 containing LOC100132919, human chromosome 7 containing AAA1 and / or NPSR1, human chromosome 7 containing ELMO1, human chromosome 8 TNKS-containing region, human chromosome 8 ANGPT1 region, human chromosome 9 PGM5 region, human chromosome 9 TMC1 region, human chromosome 9 ROR2 region, human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing area, human number Region containing two chromosomal CUX2, and probes that can hybridize to a region comprising at least one polymorphic sites in at least one region selected from the group consisting of a region including a TOM1L1 human chromosome 17
  6. 請求項５記載の試薬を含む、正常眼圧緑内障の検査キット。 A test kit for normal-tension glaucoma comprising the reagent according to claim 5.
  7. ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む最長１０００塩基長の連続したＤＮＡ部分配列又はその相補鎖からなるポリヌクレオチドを含む正常眼圧緑内障診断用マーカー遺伝子。 Includes the region containing ELOVL5 of human chromosome 6, the region containing SRBD1 of human chromosome 2, the region containing ARPP-21 of human chromosome 3, the region containing EPHA5 of human chromosome 4, and the GMDS of human chromosome 6. A region containing 6p21.3 of human chromosome 6 (including HSPA1B), a region containing SYTL3 of human chromosome 6, a region containing NXPH1 of human chromosome 7, a region containing LHFPL3 of human chromosome 7, human Region containing GLB1L3 of chromosome 11, region containing ZNF407 of human chromosome 18, region containing PAX7 of human chromosome 1, region containing PTPRF of human chromosome 1, 1q12-q21.1 of human chromosome 1 ( Region containing CHD1L and / or FMO5), region containing 1q21.2-q21.3 of human chromosome 1 (including FDPS and / or ASH1L and / or KCNN3), FAM5B of human chromosome 1 and / or A region containing ASTN1, a region containing PKP1 of human chromosome 1, KLHL29 of human chromosome 2, and / or Is a region containing FLJ14126, a region containing THRB of human chromosome 3, a region containing MED12L and / or CLRN10S and / or GPR171 of human chromosome 3, a region containing SORBS2 of human chromosome 4, MAST4 of human chromosome 5 A region containing GLRX and / or C5orf27 of human chromosome 5, a region containing EBF1 of human chromosome 5, a region containing DOCK2 of human chromosome 5, 6p21.31-p21.3 of human chromosome 6 (Including HLA-DPA1), a region containing LOC100132919 of human chromosome 6, a region containing AAA1 and / or NPSR1 of human chromosome 7, a region containing ELMO1 of human chromosome 7, A region containing TNKS, a region containing ANGPT1 of human chromosome 8, a region containing PGM5 of human chromosome 9, a region containing TMC1 of human chromosome 9, a region containing ROR2 of human chromosome 9, and the human chromosome 9 Region containing PPP6C and / or C9orf126, GRID1 of human chromosome 10 A region containing 11p11.2 of human chromosome 11 (including SPI1 and / or SLC39A13 and / or PSMC3 and / or RAPSN and / or NUP160), a region containing OR5R1 of human chromosome 11, human chromosome 11 A region containing MS4A7 and / or MS4A14, a region containing MAP6 and / or GDPD5 and / or SERPINH1 of human chromosome 11, a region containing 11q23-24 of human chromosome 11 (including PCSK7 and / or RNF214), human The region containing TAOK3 of chromosome 12, the region containing STX2 of human chromosome 12, the region containing CARS2 of human chromosome 13, the region containing CYP19A1 of human chromosome 15, the region containing CA10 of human chromosome 17, A region containing LOC643542 of chromosome 18, a region containing PTPRT of human chromosome 20, a region containing ITSN1 of human chromosome 21, a region containing LRP2 of human chromosome 2, APIP and / or PDHX of human chromosome 11. Containing region, human first A continuous DNA partial sequence having a maximum length of 1000 bases comprising at least one polymorphic site in at least one region selected from the group consisting of a region containing CUX2 of chromosome and a region containing TOM1L1 of human chromosome 17; A marker gene for diagnosing normal-tension glaucoma comprising a polynucleotide comprising the complementary strand.
  8. 請求項７記載のマーカー遺伝子のＤＮＡ配列を含有するベクター。 A vector containing the DNA sequence of the marker gene according to claim 7.
  9. 請求項８記載のベクターで形質転換した宿主細胞。 A host cell transformed with the vector according to claim 8.
  10. 請求項７記載のマーカー遺伝子のＤＮＡ配列を含有するベクターで形質転換した宿主細胞を培養し、培養物から請求項７記載のマーカー遺伝子のＤＮＡ配列がコードするポリペプチドを採取することを含む、ポリペプチドの製造方法。 A method comprising: culturing a host cell transformed with a vector containing the DNA sequence of the marker gene according to claim 7; and collecting a polypeptide encoded by the DNA sequence of the marker gene according to claim 7 from the culture. A method for producing a peptide.
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