WO2010055850A1 - Agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe - Google Patents

Agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe Download PDF

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Publication number
WO2010055850A1
WO2010055850A1 PCT/JP2009/069193 JP2009069193W WO2010055850A1 WO 2010055850 A1 WO2010055850 A1 WO 2010055850A1 JP 2009069193 W JP2009069193 W JP 2009069193W WO 2010055850 A1 WO2010055850 A1 WO 2010055850A1
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WIPO (PCT)
Prior art keywords
influenza virus
hinokitiol
virus infection
antibacterial hand
washing detergent
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PCT/JP2009/069193
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English (en)
Japanese (ja)
Inventor
一夫 岩井
吉信 斉藤
哲夫 仁科
Original Assignee
株式会社ピーアンドピーエフ
株式会社ジェイシーエス
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Publication of WO2010055850A1 publication Critical patent/WO2010055850A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/16—Foams
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2037—Terpenes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2068—Ethers

Definitions

  • the present invention relates to a foaming antibacterial hand washing detergent for preventing influenza virus infection, which has a high effect of preventing influenza virus infection, is excellent in safety, does not need to be washed away, and needs to be wiped off. No foaming antibacterial hand washing detergent.
  • anti-influenza drugs have been actively researched and developed, and drugs capable of suppressing the growth of influenza viruses such as Tamiflu (registered trademark) and Zanamiville (registered trademark) have been developed.
  • these anti-influenza drugs are not limited to a narrow range of usable periods, and are not necessarily suitable for general use from the viewpoint of side effects.
  • it has the action of suppressing the virus at the individual level, it cannot prevent the spread of influenza virus infection.
  • it is very difficult to prevent the spread of new influenza viruses (type A, H1N1 subtype) that do not have immunity. Therefore, in order to prevent the spread of influenza virus infection, it is recommended that hand washing, gargle, hand disinfection, etc. be performed frequently.
  • Patent Document 1 discloses a composition for foam sterilization / disinfection / cleaning agent containing hinokitiol, a hinokitiol salt or a hinokitiol complex as a sterilizing component.
  • Japanese Patent Application Laid-Open No. 2006-1911 discloses that a specific surfactant is used to form a foam, so that it is possible to form a very fine foam with good foaming, and the foam disappears relatively quickly when rubbed by hand. It is described that there is no stickiness after use, and that the composition exhibits a bactericidal, disinfecting and cleaning effect against various bacteria.
  • Japanese Patent Application Laid-Open No. 2006-1911 does not describe anything about a foaming antibacterial hand washing detergent for preventing influenza virus infection.
  • An object of the present invention is to provide a foaming antibacterial hand-washing detergent that is highly effective in preventing influenza virus infection, is highly safe, does not need to be washed away, and does not need to be wiped off.
  • a specific composition containing hinokitiol which is a natural material excellent in safety, or a metal complex thereof or a salt thereof and a polyalkylene glycol ether is an influenza virus.
  • the composition has good foaming and can form extremely fine foams.
  • the foam disappears relatively quickly when rubbed by hand, and there is no stickiness after use.
  • the present invention has been completed by finding that it can be used as an antibacterial antibacterial hand washing detergent with excellent foaming properties. Further, the foaming antibacterial hand washing detergent of the present invention can be expected to prevent the spread of new influenza virus (A type, H1N1 subtype) infection.
  • the present invention (1) An antibacterial hand washing detergent for preventing influenza virus infection, (A) 0.01 to 5.0% by weight of polyalkylene glycol ether and (b) 0.0001 to 1.0% by weight of hinokitiol or a metal complex thereof or a salt thereof, In addition to the above ingredients, foaming antibacterial hand-washing detergent containing water, ethanol and glycerin, (2) A foaming antibacterial hand-washing detergent for preventing influenza virus infection according to (1), wherein the pH is adjusted to 5.5 to 7, (3) A foaming antibacterial hand-washing detergent for preventing influenza virus infection according to (1) or (2), wherein the polyalkylene glycol ether has an HLB of 10 or more, (4) The foaming antibacterial hand-washing detergent for preventing influenza virus infection according to (1) or (2), wherein the polyalkylene glycol ether is polyoxyethylene oleyl ether, (5) Said (1) thru
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention can effectively prevent influenza virus infection even in the use of a small amount of hinokitiol, its metal complex or a salt thereof. Therefore, it is possible to provide a cleaning composition with high safety and high practicality. In particular, when a metal complex of hinokitiol having a high anti-influenza virus effect is used, the amount of hinokitiol used can be reduced.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention has not only an antiviral effect against human influenza virus, but also an excellent antiviral effect against avian influenza virus, This is useful not only for preventing human influenza virus infection but also for preventing avian influenza virus infection. In particular, it can be expected to prevent the spread of new influenza viruses (type A, H1N1 subtype).
  • the foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention is foamy and thus has no problem in the aqueous solution type. In other words, once it is taken out of the container, it will not sag, and since the amount used will be less than that of the aqueous solution, the hands and application site will not get wet, and there is no need to wipe or dry. . Moreover, since it is used by rubbing by hand until the foam disappears at the application site, the application site can be uniformly contacted, and the contact area is larger than that of the aqueous solution type. Furthermore, since the antiviral effect is exhibited by the foam, even a small amount can be expected to prevent influenza virus infection.
  • polyalkylene glycol ether which is a nonionic surfactant is used.
  • polyalkylene glycol ether which is a nonionic surfactant is used.
  • hinokitiol or a metal salt or metal complex thereof, which is delayed in action is used as the antiviral component, it is particularly effective that no washing or wiping is required. Furthermore, there is no stickiness after use.
  • foaming antibacterial hand washing detergents There are two types of foaming antibacterial hand washing detergents: pump foam type and aerosol type.Aerosol type is foamed with the help of propellant, but in the foam type, foaming property of nonionic surfactant itself Is required to be particularly good. Since the foaming property of the nonionic surfactant is extremely good, foaming is good even when the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is of a pump foam type. If a surfactant having an HLB of 10 or more is used as the above-mentioned surfactant, the solubility in water becomes high, so that foaming is further improved.
  • Anionic surfactants and amphoteric surfactants have too high foaming properties, and it is difficult for bubbles to disappear when they are rubbed by hand. Therefore, washing and wiping are required.
  • Anionic surfactants and cationic surfactants are irritating to the skin and therefore need to be washed away and wiped off. Since the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention does not contain any of an anionic surfactant, an amphoteric surfactant and a cationic surfactant, there is no such problem.
  • Freon gas In the case of the aerosol type, Freon gas, petroleum liquefied gas, nitrogen gas, carbon dioxide gas, etc. are used as a propellant, which causes problems in terms of environment and safety. If the foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention is a non-aerosol type that does not require a propellant, there is no such problem.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention (A) 0.01 to 5.0% by weight of polyalkylene glycol ether and (b) 0.0001 to 1.0% by weight of hinokitiol or a metal complex thereof or a salt thereof, In addition to the above components, it contains water, ethanol and glycerin.
  • ⁇ Component (a)> polyalkylene glycol ether which is a nonionic surfactant is used as the surfactant.
  • the foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention has good foaming and extremely fine foam, which is compared with rubbing by hand Since the foam disappears quickly, there is no need for washing, wiping, etc., and there is an effect that it does not become sticky after use.
  • polyalkylene glycol ether examples include compounds of the following general formula (I).
  • R 1 and R 2 are the same or different and each represents a hydrogen atom, an alkyl group having 10 to 20 carbon atoms or an alkenyl group having 10 to 20 carbon atoms, provided that R 1 is a hydrogen atom; R 2 is not a hydrogen atom, R 3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and m represents an integer of 2 to 50).
  • the “alkyl group having 10 to 20 carbon atoms” in R 1 and R 2 may be linear or branched, and preferably has 12 to 18 carbon atoms.
  • the “alkenyl group having 10 to 20 carbon atoms” in R 1 and R 2 may be linear or branched, and preferably has 18 to 18 carbon atoms.
  • the “alkyl group having 1 to 5 carbon atoms” in R 3 may be linear or branched, and preferably has 1 to 3 carbon atoms.
  • m is preferably 10 to 30.
  • polyalkylene glycol ether of the above general formula (I) there are a monoether body and a diether body.
  • a monoether body is preferable from the viewpoint of higher hydrophilicity.
  • polyethylene glycol ether that is, R 3 is a hydrogen atom
  • the polyethylene glycol monoether include polyoxyethylene monolauryl ether, polyoxyethylene monooleyl ether, polyoxyethylene monocetyl ether, polyoxyethylene monostearyl ether, polyoxyethylene monoisostearyl ether, polyoxyethylene Examples include ethylene monobehenyl ether.
  • polyoxyethylene monolauryl ether, polyoxyethylene monooleyl ether, polyoxyethylene monocetyl ether, polyoxyethylene monoisostearyl ether are particularly excellent in foamability.
  • polyoxyethylene monooleyl ether is particularly preferred.
  • the above-mentioned polyalkylene glycol ether preferably has an HLB of 10 or more, particularly 10 to 25. If the HLB is less than 10, the solubility in water will be low, and foaming may be reduced.
  • the above polyalkylene glycol ethers may be used alone or in combination of two or more.
  • the content of polyalkylene glycol ether is 0.01 to 5.0% by mass, particularly 0.1 to 1.0% by mass. Is preferred.
  • the content is less than 0.01% by mass, the composition of the present invention is not foamed. Conversely, if it exceeds 5.0 mass%, the foam becomes dense and the antifoaming property may be deteriorated.
  • foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention other nonionic surfactants such as lecithin, lecithin derivatives, acrylic polymers, as long as the effects of the present invention are not inhibited.
  • An emulsifier or the like may be used in combination.
  • the hinokitiol or its metal complex or a salt thereof as the component (b) used in the present invention functions as an active ingredient for preventing influenza virus infection.
  • the hinokitiol used in the present invention may be a natural product extracted from an essential oil derived from a raw material plant such as Thai cypress, hiba, asunaro, or a chemically synthesized product. Commercially available hinokitiol may be used as it is.
  • hiba is preferable from the viewpoint of availability. Extraction and purification of hinokitiol from the raw material plant can be performed by a known method.
  • As the essential oil Hiba oil is preferable.
  • Chemically synthesized products can also be obtained by known methods. Examples of commercially available products include those sold by Takasago Fragrance Co., Ltd. and Osaka Organic Chemical Industry Co., Ltd.
  • Examples of the metal complex of hinokitiol include metal complexes of hinokitiol and zinc, copper, iron, calcium, aluminum, magnesium, barium, tin, cobalt, titanium, vanadium, bismuth, and the like.
  • the ratio of hinokitiol to metal is not particularly limited, but usually, a hinokitiol: metal molar ratio of 2: 1 or 3: 1 is preferably used.
  • salts of hinokitiol or hinokitiol metal complexes include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts and barium salts; transition metal salts such as copper salts and zinc salts; diethanolamine Salts, alkanolamine salts such as 2-amino-2-ethyl-1,3-propanediol salt, triethanolamine salt; heterocyclic amine salts such as morpholine salt, piperazine salt, piperidine salt, ammonium salt, arginine salt, lysine And organic salts such as basic amine salts such as salts and histidine salts.
  • alkali metal salts such as sodium salts and potassium salts
  • alkaline earth metal salts such as calcium salts, magnesium salts and barium salts
  • transition metal salts such as copper salts and zinc salts
  • diethanolamine Salts alkanolamine salts such as 2-amino-2
  • the complex may be a complex compound of an aluminum compound and hinokitiol.
  • the aluminum compound include aluminum oxide, aluminum hydroxide, aluminate, chlorohydroxyaluminum, aluminum chloride, aluminum fluoride, aluminum sulfate, aluminum nitrate, aluminum borate, aluminum phosphate, potassium alum, and ammonium.
  • examples include inorganic aluminum compounds such as alum and sodium alum. The following organoaluminum compounds can also be used.
  • aluminum salts of monobasic or dibasic carboxylic acids such as aluminum acetate, aluminum propionate, aluminum tartrate, aluminum lactate, aluminum citrate, aluminum gluconate, aluminum salicylate, aluminum benzoate; aluminum laurate, myristic acid
  • Aluminum salts of fatty acids such as aluminum, aluminum palmitate, aluminum stearate, aluminum isostearate, aluminum oleate
  • aluminum salts of amino acids such as aluminum glutamate, aluminum aspartate, aluminum cysteine, aluminum sarcosine, ⁇ -alaninate ;
  • the complex compound of hinokitiol and an aluminum compound may be an aluminum salt of hinokitiol, a complex compound of hinokitiol and an aluminum compound or a complex compound thereof depending on the type and pH of the aluminum compound used. Coexisting state.
  • hinokitiol or a salt thereof is mixed with ethyl alcohol, water and the like at room temperature, and this mixed solution is an aqueous solution of aluminum compound or liquid paraffin. It is carried out by pouring and mixing in a non-aqueous solution such as the above or a mixed solution thereof.
  • hinokitiols or metal complexes thereof or salts thereof may be contained alone or in combination of two or more, and preferably two or more metals are used.
  • the metal is sodium, zinc, aluminum or a mixture thereof.
  • Component b) is preferably hinokitiol, an alkali metal salt of hinokitiol, a hinokitiol copper complex, a hinokitiol zinc complex, a hinokitiol zinc chloride mixture, a hinokitiol aluminum complex, a hinokitiol bismuth complex, or a mixture thereof.
  • Zinc complexes, hinokitiol zinc chloride mixtures, hinokitiol aluminum complexes or mixtures thereof are more preferred.
  • a hinokitiol metal complex or a metal complex salt since the light resistance of the hinokitiol metal complex or the metal complex salt is superior to that of the hinokitiol, it is preferable to use a hinokitiol metal complex or a metal complex salt when weather resistance is required. Furthermore, a metal complex of hinokitiol or a salt of a metal complex is preferable from the economical aspect because it exhibits the same effect at a concentration lower than that of hinokitiol (for example, a concentration of about 1/10).
  • hinokitiol forms a complex or salt with the metal of the metal salt depending on the conditions in the solution.
  • hinokitiol and alkali metal hydroxide are present in the solution.
  • the solution corresponds to one containing hinokitiol and a hinokitiol alkali metal salt
  • both hinokitiol and a zinc compound are present in the solution
  • the solution is one containing hinokitiol and a hinokitiol zinc complex.
  • the solution corresponds to one containing hinokitiol and a hinokitiol aluminum complex.
  • hinokitiol: metal salt 1.6 to 2.4: 1, more preferably 1.8 to 2.2: 1.
  • hinokitiol: metal salt 2.4 to 3.6: 1, more preferably 2.7 to 3.3: 1.
  • the range (molar ratio) is preferable.
  • the amount of hinokitiol used is 0.8 to 1.2 of the monovalent metal salt.
  • Times the molar amount more preferably 0.9 to 1.1 times the molar amount, and 1.6 to 2.4 times the molar amount of the divalent metal salt, more preferably 1.8 to 2.2 times. It is preferable to add the molar amount of the trivalent metal salt to the molar amount of 2.4 to 3.6 times, more preferably 2.7 to 3.3 times that of the trivalent metal salt.
  • the molar ratio of hinokitiol to zinc chloride is preferably in the range of 1.6 to 2.4: 1, and 1.8 to 2.2: 1. It is more preferable to set the range.
  • the content of component b) in the foaming antibacterial hand washing detergent for preventing influenza virus infection according to the present invention depends on the type of component b) used, but is usually 0.0001 to 1.0% by mass. Range. Further, 0.01 to 1% by mass, 0.01 to 0.5% by mass, 0.15 to 1% by mass, and 0.15 to 0.5% by mass can be preferably used. If the content is less than 0.0001% by mass, the effect cannot be expected. Conversely, if the content exceeds 1.0% by mass, there is a possibility of causing a problem in safety to the skin.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention contains water, ethanol and glycerin in addition to the components (a) and (b).
  • the water used in the present invention is preferably distilled water.
  • the content of water is such that the above component (a) nonionic surfactant or component (b) falls within the above range. Is adjusted as appropriate. It is preferable to add ethanol and glycerin used in the present invention within a range in which the foamability of the cleaning agent does not decrease.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention preferably further contains citric acid and / or an alkali metal salt of citric acid. Sodium citrate is preferred as the alkali metal salt of citric acid.
  • the foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention preferably further contains ethylenediaminetetraacetic acid or an alkali metal salt thereof. An alkali metal salt of ethylenediaminetetraacetic acid is preferred, and disodium ethylenediaminetetraacetic acid is preferred.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention preferably further contains etidronic acid or an alkali metal salt thereof. An alkali metal salt of etidronic acid is preferred, and tetrasodium etidronate is preferred.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention other components may be added as long as the effects of the present invention are not inhibited.
  • diglycerin diglycerin derivatives ( For example, polyoxypropylene (9) diglyceryl ether, polyoxypropylene (14) diglyceryl ether), ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, 1,3-butylene glycol, hexylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, sorbitol, xylitol, erythritol, sugar, maltitol, trehalose, glucose Moisturizers such as cosyl trehalose, hyaluronic acid, sodium hyaluronate,
  • foaming antibacterial hand-washing detergent for preventing the influenza virus infection of this invention.
  • a foaming antibacterial hand-washing detergent containing 0.01 to 5.0% by mass of the above polyalkylene glycol ether, 0.0001 to 1.0% by mass of hinokitiol, water, ethanol and glycerin.
  • a foaming antibacterial hand washing detergent comprising 0.01 to 5.0% by mass of the above polyalkylene glycol ether, 0.0001 to 1.0% by mass of hinokitiol sodium salt, water, ethanol and glycerin.
  • a foaming antibacterial hand washing detergent comprising 0.01 to 5.0% by mass of the above polyalkylene glycol ether, 0.0001 to 1.0% by mass of hinokitiol zinc complex, water, ethanol and glycerin.
  • a foaming antibacterial hand washing detergent comprising 0.01 to 5.0% by mass of the above polyalkylene glycol ether, 0.0001 to 1.0% by mass of hinokitiol zinc chloride mixture, water, ethanol and glycerin.
  • a foaming antibacterial hand washing detergent containing 0.01 to 5.0% by mass of the above polyalkylene glycol ether, 0.0001 to 1.0% by mass of hinokitiol aluminum complex, water, ethanol and glycerin.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention does not contain an anionic surfactant or an amphoteric surfactant or a cationic surfactant. This eliminates bubbles when rubbed by hand and does not cause skin irritation, thus eliminating the need for washing and wiping.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is the above component a), component b) water, ethanol and glycerin, and other components added as necessary, and mixed. To be prepared.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is preferably adjusted to a final pH of 5.5 to 7 from the viewpoint of its antiviral activity.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention has not only an antiviral effect against human influenza virus but also an antiviral effect against avian influenza virus. It can be used not only to prevent viral infection but also to prevent avian influenza virus infection.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention can be expected to prevent the spread of new influenza virus (A type, H1N1 subtype) infection.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is foamy, it does not sag when it is once taken out from the container, and the amount used is less than that of the aqueous solution. As a result, hands and application sites do not get wet all the time, and there is no need to wipe or dry. Moreover, since it is used by rubbing by hand until the foam disappears at the application site, the application site can be uniformly contacted, and the contact area is larger than that of the aqueous solution type. Furthermore, since the antiviral effect is exhibited by the foam, even a small amount can be expected to prevent influenza virus infection.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is an aerosol type that is foamed with the help of a propellant and a pump foam type that is a non-aerosol type that does not use a propellant Either of these can be applied.
  • foaming is caused by the foaming property of the surfactant itself, but since the foaming property of the nonionic surfactant used in the present invention is very good, it can be a pump foam type. Become. Since this pump foam type does not require a propellant, there are no environmental or safety problems as in the aerosol type.
  • the amount of hinokitiol used was an equimolar amount of sodium hydroxide + a double molar amount of zinc chloride + a triple molar amount of aluminum chloride.
  • the foaming antibacterial hand-washing detergent obtained above was filled in a pump former (manufactured by Yamato Seisaku), and an evaluation test was performed by the following method. The results are shown in Table 1.
  • Foaming One push (0.4 g) of the pump former was taken out and the foam was taken out, and this was visually evaluated according to the following four criteria.
  • ⁇ Many foams are formed and the foams are slightly creamy.
  • ⁇ Foam formation is small and foam is coarse.
  • X No bubbles are formed. 2.
  • Defoaming property One push (0.4 g) of the pump former was taken out and the foam was taken out by hand and rubbed by hand.
  • the defoaming property at this time was evaluated according to the following four criteria.
  • a feeling of use The pump former was pushed 1 (0.4g), the foam was taken out in the hand, and this was rubbed by hand.
  • the sticky feeling after use at this time was evaluated according to the following three-stage criteria. ⁇ : No stickiness after use. ⁇ : There is a little stickiness after use.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection prepared in Example 1 is excellent in foaming, antifoaming properties and feeling of use. I understand that.
  • Test Example 1 Human influenza virus inactivation test Sample: The foaming antibacterial hand washing detergent obtained in Example 1 was used as a test solution. 2.
  • Outline of test 1) Test virus: human influenza virus type A (H1N1) 2) Cells used: MDCK (NBL-2) cells ATCC CCL-34 strain (Dainippon Pharmaceutical Co., Ltd.) 3) Preparation of virus suspension i) Cell culture Using cell growth medium, the cells to be used are cultured in a monolayer in a tissue culture flask. ii) Inoculation of virus After the monolayer culture, the cell growth medium was removed from the flask and inoculated with the test virus.
  • a cell maintenance medium is added and cultured in a carbon dioxide incubator (CO 2 concentration: 5%) at 37 ° C. ⁇ 1 ° C. for 1 to 5 days.
  • CO 2 concentration: 5% carbon dioxide
  • a cell maintenance medium is added and cultured in a carbon dioxide incubator (CO 2 concentration: 5%) at 37 ° C. ⁇ 1 ° C. for 1 to 5 days.
  • iii) Preparation of virus suspension After culturing, the morphology of cells is observed using an inverted phase contrast microscope to confirm that morphological changes (cytopathic effect) have occurred in the cells.
  • the culture solution is centrifuged (3,000 r / min, 10 minutes), and the resulting supernatant is used as a virus suspension.
  • ii) Main test 0.5 mL of the virus suspension is added to 0.5 mL of the sample and mixed to obtain a working solution. Allow to act at room temperature and dilute with cell maintenance medium after 30 minutes. However, the working fluid should be diluted at the dilution concentration confirmed in the preliminary test. The purified water is also tested as a control, and the measurement is performed at the start and after 30 minutes. 5) Measurement of virus infectivity titer After using the cell growth medium, the cells to be used are cultured in a monolayer in a tissue culture microplate (96 wells), and then the cell growth medium is removed and 0.1 mL of cell maintenance medium is added.
  • TCID 50 tissue culture infectious dose
  • Test Example 2 Antiviral effect against human influenza virus (PR-8 strain) Sample The foaming antibacterial hand-washing detergent obtained in Example 1 was used as a test solution. 2. Test purpose The inactivation test of the specimen prepared above against influenza virus (PR-8 strain) is conducted. 3. Outline of the test Influenza virus solution was added to and mixed with the sample to prepare a working solution. Inversion mixing was performed at room temperature for 60 minutes, and the virus infectivity of the working solution was measured after the action. As controls, a 30% ethanol aqueous solution and a phosphate buffer (PBS) were used. 4).
  • PBS phosphate buffer
  • Test method 1 Test virus Influenza virus (PR-8 strain) (Influenz virus PR8 strain) (inoculated into the eggs of the growing chickens, collected 2 days later HA: 2048) 2) Cells used MDCK cells (RIKEN BioResource Center) 3) Medium used (1) Cell growth medium A Dulbecco's modified MEM (Sigma) supplemented with kanamycin (0.05 mg / mL) and fetal bovine serum (10%) was used. (2) Cell maintenance medium What added kanamycin (0.05 mg / mL), trypsin, and BSA (0.1%) to Dulbecco's modified MEM (Sigma) was used. 4) Virus suspension The test virus solution was diluted 100 times with PBS and used.
  • Test operation 0.5 mL of the virus suspension was added to and mixed with 0.5 mL of the sample to prepare a working solution. After acting by inversion mixing at room temperature for 60 minutes, the working solution was serially diluted 10-fold with 0.1% BSA / PBS.
  • Test Example 3 Antiviral effect against avian influenza virus 1
  • Avian influenza virus A / whisling swan / Shimane / 499/1983 is a weakly attenuated H5 subtype virus isolated from swan dung that came to Shimane Prefecture in 1983
  • the 83 (H5N3) strain was successfully intensified by passage with chicks.
  • the attenuated virus was used in the following experiments.
  • SPF 10-day-old embryonated chicken egg A fertilized egg was purchased from Aoki breeding ground in Tochigi Prefecture, incubated and used for experiments. 3) Test
  • the hand washing detergent obtained in Example 1 was used as a test solution. An equal amount of virus solution was added to the test solution prepared above and mixed well.
  • test solution-virus mixture was rapidly diluted 10-fold with PBS, and into each chorioallantoic cavity of three 10-day-old chicken eggs for each dilution. Each 0.2 mL was inoculated. The inoculated growing chicken eggs were cultured at 37 ° C. for 48 hours, and then the presence or absence of virus growth in chorioallantoic fluid was confirmed by a 0.5% chicken hemagglutination (HA) test.
  • HA chicken hemagglutination
  • the residual virus titer was calculated by the method of Reed and Muench.
  • the cumulative negative number, cumulative positive number and cumulative positive rate in each test solution-virus mixture are shown in Tables 4 and 5, and the virus titers are summarized in Table 6.
  • Example 1 the survival of the virus was not recognized as long as it was examined by contact with the hand-washing detergent obtained in Example 1 and the avian influenza virus at room temperature for 10 minutes. It became clear that it was inactivated. It was confirmed that the hand washing detergent obtained in Example 1 has an antiviral effect against avian influenza virus.
  • Test Example 4 Antibacterial effect test ⁇ each test sample>
  • Foam of Example 1 a composition obtained by filling the composition of Example 1 into a pump former (manufactured by Yamato Seisakusho)
  • Control foam a composition containing distilled water instead of hinokitiol in Example 1 (nonionic surfactant 0) .5% by weight) filled in a pump former (manufactured by Yamato Seiyaku)
  • Ethanol Gel Clean gel for hand made by Huma Killer (with 70% ethanol content and aloe extract) 70% ethanol.
  • ⁇ Used strain E. coli Escherichia coli FMK1254 Pathogenic Escherichia coli Escherichia coli O157H7 strain S. aureus Staphylococcus aureus ATCC 25923.
  • Agar medium MacConkey Agar (Difco): E. coli E. coli. E. coli FMK1254 and pathogenic E. coli E. coli. Used for E. coli O157H7 strain
  • Nutrient Agar S. aureus S. aureus Used for aureus ATCC 25923.
  • the bacterial solution was diluted with physiological saline to prepare a bacterial solution of about 10 4 CFU / ml. 2) 4.5 g of each test sample was added to each of the Petri dishes (the foam and the control foam of Example 1 were added as foam), and 0.5 ml of the bacterial solution of 1) above was inoculated into each Petri dish sufficiently. Two sets of each mixed test sample were prepared. 3) For each test solution, the number of bacteria was measured immediately after inoculation with the bacterial solution and after incubation at 37 ° C. for 1 hour and 2 hours. Insulation was performed with the petri dish lid slightly lifted in an incubator.
  • the number of bacteria was measured by converging 0.1 ml of the bacterial solution on two agar media and then culturing at 37 ° C. for 24 hours to count the number of colonies, and the average value was calculated. 4)
  • the second set of sample solutions prepared in 2) above was kept at 37 ° C. for 2 hours after inoculation with the bacterial solution, and 0.5 ml of the bacterial solution was again inoculated and mixed well. Thereafter, by the same method as in 3) above, the number of bacteria was measured immediately after re-inoculation of the bacterial solution and after incubation at 37 ° C. for 1 hour and 2 hours.
  • Tables 7-9 The results of these antibacterial effect tests are shown in Tables 7-9.
  • “B” indicates the calculated number of bacteria in the mixed solution of the bacterial solution and each test sample, and “*” indicates the time of re-inoculation.
  • Example 1 showed an excellent antibacterial effect for any of the bacteria at 2 hours after inoculation and at 2 hours after reinoculation.
  • the control foam without hinokitiol formulation
  • the excellent antibacterial effect of Example 1 is due to hinokitiol.
  • About 2 hours after inoculation, ethanol gel showed excellent antibacterial effect against any bacteria, but 2 hours after reinoculation showed excellent antibacterial effect against Escherichia coli and Staphylococcus aureus. However, no antibacterial effect was observed against pathogenic E. coli.
  • 70% ethanol showed an excellent antibacterial effect against any bacterium at 2 hours after inoculation, but no antibacterial effect was observed against Staphylococcus aureus at 2 hours after reinoculation. No antimicrobial effect was observed against E. coli and pathogenic E. coli. As a main factor that the antibacterial effect of 2 hours after 70% ethanol re-inoculation is inferior to that of ethanol gel, it is considered that ethanol has evaporated.
  • Test Example 5 Safety test The safety test shown below was carried out on the hand-washing detergent obtained in Example 1. i) 28-day dietary toxicity test using rats ii) Acute oral toxicity test in rats iii) Skin irritation test using rabbits iv) Eye irritation test using rabbits v) Reverse mutation test using bacteria It turned out that the toxicity of the hand-washing detergent obtained in Example 1 is not different from that of highly safe hinokitiol. In all tests, no abnormality was observed.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention has not only an antiviral effect against human influenza virus but also an antiviral effect against avian influenza virus. It can be used not only to prevent viral infection but also to prevent avian influenza virus infection. In particular, it is expected that infection with a new influenza virus (type A, H1N1 subtype) will be effectively prevented. Moreover, the foaming antibacterial hand-washing detergent for preventing influenza virus infection of the present invention does not need to be washed off, wiped off, etc., and can be used at any place because it can be rubbed by hand. In particular, the utility value is very high in places where there is no water or where the water is contaminated. It is also convenient for portable use.
  • the foaming antibacterial hand washing detergent for preventing influenza virus infection of the present invention is very useful industrially.

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Abstract

L'invention porte sur un agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe. L'invention porte spécifiquement sur un agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe, qui contient (a) de 0,01 à 5,0 % en poids d'un éther de polyalkylène glycol et (b) de 0,0001 à 1,0 % en poids de hinokitiol, d'un complexe métallique de celui-ci ou d'un sel d'hinokitiol ou du complexe métallique. L'agent antibactérien moussant de lavage des mains contient également de l'eau, de l'éthanol et de la glycérine. L'agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe a un excellent effet antiviral non seulement sur les virus de la grippe humaine mais également sur les virus de la grippe aviaire.
PCT/JP2009/069193 2008-11-11 2009-11-11 Agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe WO2010055850A1 (fr)

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JP2008289001A JP2012020938A (ja) 2008-11-11 2008-11-11 インフルエンザウイルス感染を予防するための泡立性の抗菌手洗い洗浄剤
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GB2482400A (en) * 2010-07-28 2012-02-01 Syntopix Group Plc Antibacterial formulation containing a tropone and a metal or metal salt
WO2012172318A1 (fr) 2011-06-17 2012-12-20 Evocutis Plc Formulations
JP2013526565A (ja) * 2010-05-20 2013-06-24 ヒョン チョン，チュン 抗菌及び抗真菌効果に優れた皮膚外用剤組成物
CN103755561A (zh) * 2014-01-10 2014-04-30 广州英赛特生物技术有限公司 β-扁柏酚酯或盐及其在制备动物饲料添加剂中的应用
WO2021214626A1 (fr) * 2020-04-23 2021-10-28 Johnson & Johnson Consumer Inc. Méthodes et compositions pour l'inhibition de virus de la grippe faisant intervenir des polymères modifiés hydrophobiquement de faible masse moléculaire et des polyalkylène glycols
WO2022000038A1 (fr) * 2020-06-30 2022-01-06 Advance NanoTek Ltd. Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps
FR3115961A1 (fr) 2020-11-06 2022-05-13 Savonnerie De La Goutte Noire Solution virucide de lavage des mains et procede de preparation

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JP2018197222A (ja) * 2017-11-01 2018-12-13 株式会社ニイタカ ウイルス不活性化剤及び衛生資材
JP7220449B2 (ja) * 2018-06-08 2023-02-10 シーバイエス株式会社 殺菌・ウイルス不活化剤及び殺菌・ウイルス不活化方法
KR102305665B1 (ko) * 2020-08-10 2021-09-28 (주)네이처페어리 황칠을 포함하는 항바이러스 또는 항균용 조성물

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JPH08259439A (ja) * 1995-03-24 1996-10-08 Otsuka Pharmaceut Co Ltd 抗ウィルス用組成物
JP2002505894A (ja) * 1998-03-12 2002-02-26 ザ、プロクター、エンド、ギャンブル、カンパニー 抗細菌性スキン・ローション含有ティシュ・ペーパー
JP2005206573A (ja) * 2003-12-22 2005-08-04 Nippon Fine Chem Co Ltd ジエステル及び油剤、並びに化粧料及び皮膚外用剤

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013526565A (ja) * 2010-05-20 2013-06-24 ヒョン チョン，チュン 抗菌及び抗真菌効果に優れた皮膚外用剤組成物
GB2482400A (en) * 2010-07-28 2012-02-01 Syntopix Group Plc Antibacterial formulation containing a tropone and a metal or metal salt
WO2012013967A2 (fr) 2010-07-28 2012-02-02 Syntopix Group Plc Nouvelles utilisations
WO2012172318A1 (fr) 2011-06-17 2012-12-20 Evocutis Plc Formulations
CN103755561A (zh) * 2014-01-10 2014-04-30 广州英赛特生物技术有限公司 β-扁柏酚酯或盐及其在制备动物饲料添加剂中的应用
CN103755561B (zh) * 2014-01-10 2015-12-09 广州英赛特生物技术有限公司 β-扁柏酚酯或盐及其在制备动物饲料添加剂中的应用
WO2021214626A1 (fr) * 2020-04-23 2021-10-28 Johnson & Johnson Consumer Inc. Méthodes et compositions pour l'inhibition de virus de la grippe faisant intervenir des polymères modifiés hydrophobiquement de faible masse moléculaire et des polyalkylène glycols
US20210330700A1 (en) * 2020-04-23 2021-10-28 Johnson & Johnson Consumer Inc. Methods and compositions for inhibiting influenza viruses using low molecular weight hydrophobically modified polymers and polyalkylene glycols
WO2022000038A1 (fr) * 2020-06-30 2022-01-06 Advance NanoTek Ltd. Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps
FR3115961A1 (fr) 2020-11-06 2022-05-13 Savonnerie De La Goutte Noire Solution virucide de lavage des mains et procede de preparation

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