WO2010047500A3 - 안질환의 예방 또는 치료용 조성물 - Google Patents

안질환의 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2010047500A3
WO2010047500A3 PCT/KR2009/005983 KR2009005983W WO2010047500A3 WO 2010047500 A3 WO2010047500 A3 WO 2010047500A3 KR 2009005983 W KR2009005983 W KR 2009005983W WO 2010047500 A3 WO2010047500 A3 WO 2010047500A3
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WO
WIPO (PCT)
Prior art keywords
eye diseases
composition
present
caused
prevention
Prior art date
Application number
PCT/KR2009/005983
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English (en)
French (fr)
Other versions
WO2010047500A2 (ko
Inventor
강승우
김철호
김석조
Original Assignee
주식회사 베네비오
성균관대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 주식회사 베네비오, 성균관대학교 산학협력단 filed Critical 주식회사 베네비오
Priority to ES09822176.5T priority Critical patent/ES2472440T3/es
Priority to US13/124,965 priority patent/US8524686B2/en
Priority to JP2011533097A priority patent/JP5611216B2/ja
Priority to DK09822176.5T priority patent/DK2361627T3/da
Priority to EP09822176.5A priority patent/EP2361627B1/en
Publication of WO2010047500A2 publication Critical patent/WO2010047500A2/ko
Publication of WO2010047500A3 publication Critical patent/WO2010047500A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/221—Mono, di- or trisaccharides or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C11D3/227—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin with nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 유효성분으로서 다음 일반식 I로 표시되는 화합물을 포함하는 안(eye) 질환의 예방 또는 치료용 조성물에 관한 것이다: 일반식 I S-(MS)p-(MS)q 상기 일반식에서, S는 시알산, (MS)p 및 (MS)q는 서로 독립적으로 단당류 잔기이다. 본 발명의 유효성분으로 이용되는 화합물은 각막 상피세포에서 MMP-9 및 염증 매개 사이토카인(IL-1β 및 TNF-α등)의 발현을 억제하고 인간 망막 내피 세포에서 VEGF-매개 VEGFR-2 활성의 억제함으로써, 궁극적으로 안구건조증, 염증성 안질환, 혈관신생에 의한 안질환 및 콘택트렌즈 사용에 기인한 눈의 부작용과 같은 안질환의 예방 또는 치료 활성을 나타낸다. 또한, 본 발명의 조성물은 세포독성 및 피부 부작용이 없어 약제학적 조성물, 기능성 식품(neutraceutical) 조성물 또는 식품 조성물에 안전하게 적용할 수 있다. 또한, 본 발명의 조성물은 콘택트렌즈 착용에 기인한 비 세균성 염증 및 안 접촉 윤활 활성을 갖는 세정제 및 윤활제로서 적용할 수 있다.
PCT/KR2009/005983 2008-10-20 2009-10-16 안질환의 예방 또는 치료용 조성물 WO2010047500A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES09822176.5T ES2472440T3 (es) 2008-10-20 2009-10-16 Composición para la prevención o tratamiento de enfermedades oculares
US13/124,965 US8524686B2 (en) 2008-10-20 2009-10-16 Composition for prevention or treatment of eye diseases
JP2011533097A JP5611216B2 (ja) 2008-10-20 2009-10-16 眼疾患の予防又は治療用組成物
DK09822176.5T DK2361627T3 (da) 2008-10-20 2009-10-16 Sammensætning til forebyggelse eller behandling af øjensygdomme
EP09822176.5A EP2361627B1 (en) 2008-10-20 2009-10-16 Composition for prevention or treatment of eye diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0102660 2008-10-20
KR1020080102660A KR101116868B1 (ko) 2008-10-20 2008-10-20 안질환의 예방 또는 치료용 조성물

Publications (2)

Publication Number Publication Date
WO2010047500A2 WO2010047500A2 (ko) 2010-04-29
WO2010047500A3 true WO2010047500A3 (ko) 2010-08-19

Family

ID=42119814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005983 WO2010047500A2 (ko) 2008-10-20 2009-10-16 안질환의 예방 또는 치료용 조성물

Country Status (7)

Country Link
US (1) US8524686B2 (ko)
EP (1) EP2361627B1 (ko)
JP (1) JP5611216B2 (ko)
KR (1) KR101116868B1 (ko)
DK (1) DK2361627T3 (ko)
ES (1) ES2472440T3 (ko)
WO (1) WO2010047500A2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101438744B1 (ko) * 2012-08-02 2014-09-15 전남대학교산학협력단 아디포넥틴을 유효성분으로 포함하는 안구건조증 또는 염증성 안구표면 질환의 예방 또는 치료용 조성물
CA2888899C (en) 2012-10-24 2023-02-21 Japan Innovative Therapeutics, Inc. Use of tryptase inhibitors in the treatment retinopathy of prematurity
WO2018171850A1 (en) * 2017-03-23 2018-09-27 Københavns Universitet Prebiotic compounds or compositions for use in treatment of sjögren's syndrome
KR102495473B1 (ko) 2020-10-06 2023-02-06 서울대학교병원 앰피레귤린을 유효성분으로 포함하는 안질환 치료용 조성물

Citations (2)

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Also Published As

Publication number Publication date
KR20100043570A (ko) 2010-04-29
EP2361627A2 (en) 2011-08-31
WO2010047500A2 (ko) 2010-04-29
KR101116868B1 (ko) 2012-02-29
JP5611216B2 (ja) 2014-10-22
JP2012505928A (ja) 2012-03-08
ES2472440T3 (es) 2014-07-01
EP2361627B1 (en) 2014-03-12
US20110237543A1 (en) 2011-09-29
US8524686B2 (en) 2013-09-03
DK2361627T3 (da) 2014-06-23
EP2361627A4 (en) 2012-05-02

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