WO2010029032A1 - Dispositif de mesure et procédé de mesure - Google Patents
Dispositif de mesure et procédé de mesure Download PDFInfo
- Publication number
- WO2010029032A1 WO2010029032A1 PCT/EP2009/061520 EP2009061520W WO2010029032A1 WO 2010029032 A1 WO2010029032 A1 WO 2010029032A1 EP 2009061520 W EP2009061520 W EP 2009061520W WO 2010029032 A1 WO2010029032 A1 WO 2010029032A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pulse wave
- pulse
- measuring
- measuring device
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6838—Clamps or clips
Definitions
- the invention relates to a measuring device according to the preamble of claim 1 and to a measuring method according to the preamble of claim 10.
- the standard therapy for patients with heart failure and chronic hypertension is the treatment with antihypertensive drugs.
- the right dosage and the right combination of prescribed medications must be evaluated individually for each case.
- the most important basis for the evaluation is a daily blood pressure measurement performed by the patient. Medication evaluation based on daily individual measurements is problematic because blood pressure is not constant throughout the day and is influenced by many factors such as body position, activity, the body's post-daytime rhythm, stress, metabolic activity and food.
- the invention has for its object to provide a measuring device, based on their measurement results waiving a blood pressure measurement, reliable statements about the effectiveness and / or the duration of action and / or the dosage of at least one drug and / or on the medik kameinein frosting a Patients can be made. Furthermore, the object is to propose a corresponding measuring method.
- the invention has recognized that the most important class of antihypertensive drugs, especially ACE inhibitors and AT2 receptor blockers, affect the vascular tension of blood vessels. Based on this finding, the further realization is that the measurement of the vascular tension is a very specific parameter for the effect of this class of drugs, as the blood pressure. Since the vascular tension, like the blood pressure, depends on various factors, such as the body position, the activity, the daytime post-rhythm of the body, stress, the metabolic activity and the ingested food, the invention proposes a measuring device designed as a long-term measuring device with which the pulse wave transit time and / or the pulse wave velocity and / or the pulse waveform can / can be measured over a relatively long period, preferably over 24 hours, very particularly preferably regularly.
- the medication intake behavior of a patient can be made by a corresponding evaluation of the pulse wave transit time and / or the pulse wave velocity and / or the pulse waveform. It is very particularly preferred if the control means of the measuring device control the measuring means in such a way that these measurements carry out at least one of the aforementioned parameters continuously or at certain, preferably regular, intervals. It is very particularly preferred if measurements can be carried out at intervals of 15 to 30 minutes, preferably at intervals of 20 minutes, in order to obtain a good overview of the vessel voltage over a relatively long period of time.
- the pulse rate can be used to check the plausibility of the measurement results.
- measurement results can be disregarded or weighted differently, which are measured at a time at which a conspicuous, for example, very high pulse rate is measured which is at an exception, for example a sudden stress or a sudden indicates physical effort.
- the measuring device evaluates the recorded measurement results with the aid of integral analysis means.
- the analysis means may be designed such that they perform an evaluation of the vessel wall tension, in particular of a patient's arterial blood vessels, on the basis of the measurement results.
- the measuring means and / or the analysis means may be part of common logic means that determine the pulse wave velocity by a signal analysis of the detected pulse shape.
- the pulse shape is in the form of a double pulse, which results from the reflection of the pulse in the arterial vasculature.
- the vascular tension has a significant influence on the time interval of the amplitudes of a double pulse.
- measuring means determine the pulse wave velocity and / or the pulse waveform on the basis of a transmission or reflection measurement.
- a body part for example a finger of a patient, is illuminated with the aid of an infrared-emitting LED.
- the optical transmission is measured by means of a photodiode, which changes due to a volume expansion due to a pulse wave propagation.
- a reflection measurement can also be carried out.
- the invention also leads to a method for determining a long-term profile of the pulse wave transit time and / or the pulse wave velocity and / or the pulse waveform, in particular with the aim of determining the vessel wall tension of preferably arterial blood vessels; this in turn with the aim of analyzing the efficacy and / or the duration of action and / or the dosage of at least one drug and / or to evaluate the drug intake behavior of a patient.
- the pulse frequency is used for plausibility of measurement results.
- the pulse wave velocity is determined on the basis of a signal analysis of a detected double pulse shape.
- the relative position of two amplitudes of the double pulse can be determined by a signal analysis processor. Immediately from knowledge of the relative amplitude position, a statement about the vessel wall tension can be made.
- the measuring device is fixed to a finger and / or a hand and / or on an arm joint and / or on an earlobe and / or toe of a patient and / or if the measurement of the pulse wave transit time and / or the pulse wave velocity and / or the pulse waveform is performed at one of these locations. It is also conceivable to select other body locations for positioning and / or performing the measurement.
- the invention also leads to the use of a previously described device for evaluating the vessel wall tension and / or the efficacy of at least one drug and / or the duration of at least one drug and / or drug intake behavior of a patient and / or the dosage of at least one drug.
- 1 is a schematic diagram of a measuring device
- Fig. 2 a schematic diagram illustrating the measuring principle of the double pulse measurement.
- FIG. 1 shows a measuring device 1 for measuring the pulse wave velocity and the pulse waveform of human pulse waves (tube waves).
- the measuring device 1 comprises only schematically indicated fastening means 2 for fixing the measuring device 1 to the human body.
- the measuring device comprises measuring means 3.
- the measuring means 3 in turn comprise an LED light source 4 for emitting infrared radiation 5 as well an IR intensity sensor 6 for detecting the transmission of the infrared radiation 5 by a human finger 7.
- the transmission decreases when a pulse wave (tube wave) through a blood vessel (in particular an artery) between the LED light sensor 4 and the sensor 6 through running.
- the measuring means 3 are associated with control means 8, which cause a measurement of the pulse wave velocity and the pulse waveform every 20 minutes over a period of 24 hours.
- the measurement result is passed via a signal-conducting connection to analysis means 9, which analyze the measurement results with respect to the vessel wall tension of the patient's blood vessels and the effectiveness of at least one drug and the duration of action of at least one drug and the dosage of at least one drug and the drug intake behavior of the patient ,
- analysis means 9 which analyze the measurement results with respect to the vessel wall tension of the patient's blood vessels and the effectiveness of at least one drug and the duration of action of at least one drug and the dosage of at least one drug and the drug intake behavior of the patient .
- the result of this analysis and the actual measurement results are stored in a memory 10. Furthermore, the measurement results and the analysis result are visualized on a screen 11. Via a plug contact 12 in a housing 13 of the measuring device 1, the measurement results and the analysis results from the memory 10 can be retrieved.
- a human body 14 with a schematically indicated heart 15 can be recognized.
- a heartbeat sends out a pulse wave through an arterial blood vessel 16 in the direction of the finger 7.
- a first pulse wave amplitude 17 can be detected. Due to the heartbeat of the heart 15, however, the pulse wave is not emitted exclusively in the direction of finger 7, but also in the Abdominal cavity into it. There it meets an arterial branch 18 (reflection point) at which it is reflected and only then propagates in the direction of finger 7.
- a second (double), smaller pulse wave amplitude 19 is detected with the aid of a measuring device.
- the time interval t between the pulse amplitudes 17, 19 and thus, knowing the distance traveled by the pulse waves, the pulse wave velocity can be determined.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physiology (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
L'invention concerne un dispositif de mesure (1) comportant des moyens de mesure (3) pour déterminer le temps de transit d'ondes pulsées et/ou la vitesse d'ondes pulsées et/ou la forme d'ondes pulsées et des moyens de fixation (2) pour fixer les dispositifs de mesure (1) sur le corps humain (14). Selon l'invention, il est prévu que les moyens de commande (8) soient conçus de façon à commander les moyens de mesure (3) de telle sorte que ceux-ci permettent de déterminer un profil à long terme du temps de transit d'ondes pulsées et/ou de la vitesse d'ondes pulsées et/ou de la forme d'ondes pulsées. En outre, l'invention concerne un procédé de mesure.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200810042115 DE102008042115A1 (de) | 2008-09-15 | 2008-09-15 | Messvorrichtung sowie Messverfahren |
DE102008042115.4 | 2008-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010029032A1 true WO2010029032A1 (fr) | 2010-03-18 |
Family
ID=41217801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/061520 WO2010029032A1 (fr) | 2008-09-15 | 2009-09-07 | Dispositif de mesure et procédé de mesure |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102008042115A1 (fr) |
WO (1) | WO2010029032A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102641121A (zh) * | 2011-02-16 | 2012-08-22 | 浙江中医药大学 | 一种评价抗高血压中药药效的新技术 |
DE102012021940A1 (de) | 2012-11-11 | 2014-05-15 | Holger Redtel | Blutdruck- und Pulsmessung mittels Pulswellenlaufzeit, mit handelsüblichen Kameras für Video und Einzelbilder, vorzugsweise mit einem Smartphone und verbundenen Geräten |
DE102013001553A1 (de) | 2013-01-30 | 2014-07-31 | Holger Redtel | Vitalparametermessung mittels Auswertung von RR- Intervallen und der Pulswellenlaufzeit, sowie Sauerstoff- und Atemmessung, Identitätserkennung, mit handelsüblichen Kameras für Video und oder Einzelbilder, Vorzugsweise mit einem Smartphone und Folgesystemen und deren verbundenen Geräten mit und ohne Berührung, Berührungsfrei-Fernmessung |
CN110881967A (zh) * | 2018-09-10 | 2020-03-17 | 深圳市迈迪优科技有限公司 | 一种无创多节段外周动脉血管弹性功能检测方法及其仪器 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014072461A1 (fr) | 2012-11-11 | 2014-05-15 | Grönemeyer Medical GmbH & Co. KG | Procédé et dispositif de détermination de paramètres vitaux |
EP3116381A1 (fr) | 2014-03-09 | 2017-01-18 | Kenkou GmbH | Système permettant de déterminer les paramètres vitaux |
EP3188650B1 (fr) * | 2014-09-05 | 2021-07-21 | Lakeland Ventures Development, LLC | Procédé et appareil pour l'estimation continue de la pression sanguine humaine au moyen d'images vidéo |
DE102015012351A1 (de) | 2015-09-22 | 2017-03-23 | Lukas Wienhues | Gerät zur Messung der Pulswellengeschwindigkeit an einem einzelnen kleinen Messfeld über einer Arterie |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6047203A (en) * | 1997-03-17 | 2000-04-04 | Nims, Inc. | Physiologic signs feedback system |
US20030036685A1 (en) * | 2000-04-27 | 2003-02-20 | Vitalsines International, Inc. | Physiological signal monitoring system |
DE10249863A1 (de) * | 2002-10-25 | 2004-05-19 | Biosign Gmbh | Verfahren und Vorrichtung zur nicht invasiven Blutdruckmessung |
EP1623669A1 (fr) * | 2004-08-05 | 2006-02-08 | Centre de Recherche Public Henri Tudor | Appareil et procédé pour une technique non invasive de surveillance de coeur |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005003678A1 (de) | 2005-01-26 | 2006-08-03 | Biosign Gmbh | Vorrichtung und Verfahren zur Messung und Beeinflussung des Blutdrucks und der Herzratenvariabilität |
-
2008
- 2008-09-15 DE DE200810042115 patent/DE102008042115A1/de not_active Withdrawn
-
2009
- 2009-09-07 WO PCT/EP2009/061520 patent/WO2010029032A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6047203A (en) * | 1997-03-17 | 2000-04-04 | Nims, Inc. | Physiologic signs feedback system |
US20030036685A1 (en) * | 2000-04-27 | 2003-02-20 | Vitalsines International, Inc. | Physiological signal monitoring system |
DE10249863A1 (de) * | 2002-10-25 | 2004-05-19 | Biosign Gmbh | Verfahren und Vorrichtung zur nicht invasiven Blutdruckmessung |
EP1623669A1 (fr) * | 2004-08-05 | 2006-02-08 | Centre de Recherche Public Henri Tudor | Appareil et procédé pour une technique non invasive de surveillance de coeur |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102641121A (zh) * | 2011-02-16 | 2012-08-22 | 浙江中医药大学 | 一种评价抗高血压中药药效的新技术 |
DE102012021940A1 (de) | 2012-11-11 | 2014-05-15 | Holger Redtel | Blutdruck- und Pulsmessung mittels Pulswellenlaufzeit, mit handelsüblichen Kameras für Video und Einzelbilder, vorzugsweise mit einem Smartphone und verbundenen Geräten |
DE102013001553A1 (de) | 2013-01-30 | 2014-07-31 | Holger Redtel | Vitalparametermessung mittels Auswertung von RR- Intervallen und der Pulswellenlaufzeit, sowie Sauerstoff- und Atemmessung, Identitätserkennung, mit handelsüblichen Kameras für Video und oder Einzelbilder, Vorzugsweise mit einem Smartphone und Folgesystemen und deren verbundenen Geräten mit und ohne Berührung, Berührungsfrei-Fernmessung |
CN110881967A (zh) * | 2018-09-10 | 2020-03-17 | 深圳市迈迪优科技有限公司 | 一种无创多节段外周动脉血管弹性功能检测方法及其仪器 |
Also Published As
Publication number | Publication date |
---|---|
DE102008042115A1 (de) | 2010-03-18 |
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