WO2010023687A3 - Préparation de la ranolazine, ses sels et des intermédiaires de ceux-ci - Google Patents

Préparation de la ranolazine, ses sels et des intermédiaires de ceux-ci Download PDF

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Publication number
WO2010023687A3
WO2010023687A3 PCT/IN2009/000463 IN2009000463W WO2010023687A3 WO 2010023687 A3 WO2010023687 A3 WO 2010023687A3 IN 2009000463 W IN2009000463 W IN 2009000463W WO 2010023687 A3 WO2010023687 A3 WO 2010023687A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
ranolazine
intermediates
salts
pharmaceutically acceptable
Prior art date
Application number
PCT/IN2009/000463
Other languages
English (en)
Other versions
WO2010023687A2 (fr
Inventor
Thota Giridhar
Gudipati Srinivasulu
Kotaru Srinivasa Rao
Original Assignee
Shodhana Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shodhana Laboratories Limited filed Critical Shodhana Laboratories Limited
Publication of WO2010023687A2 publication Critical patent/WO2010023687A2/fr
Publication of WO2010023687A3 publication Critical patent/WO2010023687A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation de la Ranolazine, ses sels pharmaceutiquement acceptables et des intermédiaires de ceux-ci. L'invention concerne spécifiquement des procédés de préparation du 1-(2-méthoxy phénoxy)-2,3-époxypropane dans un milieu de solvants essentiellement aqueux et du 2-chloro-N-(2,6-diméthylphényl)acétamide sans utiliser de base additionnelle, qui sont des intermédiaires, utiles dans la préparation de la Ranolazine et des sels pharmaceutiquement acceptables de celle-ci.
PCT/IN2009/000463 2008-08-28 2009-08-21 Préparation de la ranolazine, ses sels et des intermédiaires de ceux-ci WO2010023687A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2105CH2008 2008-08-28
IN2105/CHE/2008 2008-08-28

Publications (2)

Publication Number Publication Date
WO2010023687A2 WO2010023687A2 (fr) 2010-03-04
WO2010023687A3 true WO2010023687A3 (fr) 2012-10-04

Family

ID=41722049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000463 WO2010023687A2 (fr) 2008-08-28 2009-08-21 Préparation de la ranolazine, ses sels et des intermédiaires de ceux-ci

Country Status (1)

Country Link
WO (1) WO2010023687A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010136522A2 (fr) * 2009-05-27 2010-12-02 Medichem S.A. Dérivé de pipérazine exempt, ou sensiblement exempt, d'une génotoxicité potentielle, et procédé de préparation associé
CN101838249B (zh) * 2010-03-19 2015-08-19 浙江华海药业股份有限公司 一种制备高纯度愈创木酚缩水甘油醚的方法
CN102295622A (zh) 2010-06-25 2011-12-28 上海冠杰生物医药科技有限公司 一种雷诺嗪的制备方法
CN103570645A (zh) * 2012-08-01 2014-02-12 上海迪赛诺化学制药有限公司 一种制备n-(2,6-二甲基苯基)-2-(1-哌嗪基)乙酰胺的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126449A1 (fr) * 1983-05-18 1984-11-28 Syntex (U.S.A.) Inc. Aryloxy- et arylthio-hydroxypropyl-pipérazinylacétanilides cardiosélectifs influençant l'entrée de calcium
WO1996040664A2 (fr) * 1995-06-07 1996-12-19 Dade Chemistry Systems Inc. Preparations d'immunogenes et d'autres conjugues de medicaments
WO2008047388A2 (fr) * 2006-10-20 2008-04-24 Ind-Swift Laboratories Limited Procédé amélioré de préparation de ranolazine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126449A1 (fr) * 1983-05-18 1984-11-28 Syntex (U.S.A.) Inc. Aryloxy- et arylthio-hydroxypropyl-pipérazinylacétanilides cardiosélectifs influençant l'entrée de calcium
WO1996040664A2 (fr) * 1995-06-07 1996-12-19 Dade Chemistry Systems Inc. Preparations d'immunogenes et d'autres conjugues de medicaments
WO2008047388A2 (fr) * 2006-10-20 2008-04-24 Ind-Swift Laboratories Limited Procédé amélioré de préparation de ranolazine

Also Published As

Publication number Publication date
WO2010023687A2 (fr) 2010-03-04

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