WO2010019864A3 - Extraits de ficus ayant une activité d'inhibition d'angiogenèse, et procédés d'isolation et d'utilisation de ceux-ci - Google Patents

Extraits de ficus ayant une activité d'inhibition d'angiogenèse, et procédés d'isolation et d'utilisation de ceux-ci Download PDF

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Publication number
WO2010019864A3
WO2010019864A3 PCT/US2009/053860 US2009053860W WO2010019864A3 WO 2010019864 A3 WO2010019864 A3 WO 2010019864A3 US 2009053860 W US2009053860 W US 2009053860W WO 2010019864 A3 WO2010019864 A3 WO 2010019864A3
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WO
WIPO (PCT)
Prior art keywords
extracts
methods
isolating
inhibiting activity
same
Prior art date
Application number
PCT/US2009/053860
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English (en)
Other versions
WO2010019864A2 (fr
Inventor
Zhijun Liu
Eugene A. Woltering
Original Assignee
Ullman Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ullman Medical, Inc. filed Critical Ullman Medical, Inc.
Priority to US13/058,957 priority Critical patent/US9066959B2/en
Publication of WO2010019864A2 publication Critical patent/WO2010019864A2/fr
Publication of WO2010019864A3 publication Critical patent/WO2010019864A3/fr
Priority to US14/662,793 priority patent/US20150190445A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)

Abstract

La présente invention concerne des procédés pour extraire et isoler des extraits ayant une activité d'inhibition d'angiogenèse à partir d'une partie contenant du latex d'une variante de ficus, des compositions pharmaceutiques et nutraceutiques comprenant les extraits, des procédés d'administration des extraits pour traiter des maladies dépendant d'une angiogenèse, et pour réduire ou inhiber une croissance de nouveaux vaisseaux chez un sujet en ayant besoin, et l'utilisation des extraits dans la fabrication d'une composition pour réduire ou inhiber une croissance de nouveaux vaisseaux.
PCT/US2009/053860 2008-08-14 2009-08-14 Extraits de ficus ayant une activité d'inhibition d'angiogenèse, et procédés d'isolation et d'utilisation de ceux-ci WO2010019864A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/058,957 US9066959B2 (en) 2008-08-14 2009-08-14 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same
US14/662,793 US20150190445A1 (en) 2008-08-14 2015-03-19 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8892408P 2008-08-14 2008-08-14
US61/088,924 2008-08-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/058,957 A-371-Of-International US9066959B2 (en) 2008-08-14 2009-08-14 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same
US14/662,793 Continuation US20150190445A1 (en) 2008-08-14 2015-03-19 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same

Publications (2)

Publication Number Publication Date
WO2010019864A2 WO2010019864A2 (fr) 2010-02-18
WO2010019864A3 true WO2010019864A3 (fr) 2010-05-27

Family

ID=41669714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/053860 WO2010019864A2 (fr) 2008-08-14 2009-08-14 Extraits de ficus ayant une activité d'inhibition d'angiogenèse, et procédés d'isolation et d'utilisation de ceux-ci

Country Status (2)

Country Link
US (2) US9066959B2 (fr)
WO (1) WO2010019864A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456553A (zh) * 2014-08-27 2016-04-06 石家庄以岭药业股份有限公司 一种中药组合物在制备治疗眼缺血综合征药物中的应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120201768A1 (en) * 2010-09-10 2012-08-09 Cheri Lynn Swanson Cosmetic compositions comprising ficus serum fraction and methods to reduce the appearance of skin hyperpigmentation
WO2012105823A1 (fr) 2011-02-02 2012-08-09 Biotropics Malaysia Berhad Utilisation cosmétique non thérapeutique d'extraits de ficus deltoidea
CN105496996A (zh) * 2014-09-23 2016-04-20 四川九章生物科技有限公司 绿原酸在制备治疗银屑病的药物中的用途
WO2016044999A1 (fr) * 2014-09-23 2016-03-31 四川九章生物科技有限公司 Utilisation de l'acide chlorogénique dans la préparation d'un médicament indiqué pour le traitement du psoriasis
CN105116092B (zh) * 2015-09-06 2016-08-17 山东省果树研究所 石榴果皮中莽草酸和3-脱氢莽草酸的hplc测定方法
CN105617112A (zh) * 2016-02-22 2016-06-01 刘东彦 治疗功能性子宫出血的中药组合物
CN113384618B (zh) * 2021-08-09 2023-03-14 山东中医药大学 一种无花果乳浆提取物作为制备治疗血管内皮细胞损伤药物的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10298089A (ja) * 1997-05-02 1998-11-10 Asahi Chem Ind Co Ltd 細胞接着阻害剤
WO2006007676A1 (fr) * 2004-07-21 2006-01-26 Amazônia Fitomedicamentos Ltda. Combinaison de fractions actives provenant des plantes euphorbia tirucalli l. et ficos carica l. et methode de traitement du cancer et du sida

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539204A1 (fr) * 2002-08-30 2005-06-15 Biopharmacopae Design International Inc. Extraits vegetaux pour le traitement de l'angiogenese et de la metastase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10298089A (ja) * 1997-05-02 1998-11-10 Asahi Chem Ind Co Ltd 細胞接着阻害剤
WO2006007676A1 (fr) * 2004-07-21 2006-01-26 Amazônia Fitomedicamentos Ltda. Combinaison de fractions actives provenant des plantes euphorbia tirucalli l. et ficos carica l. et methode de traitement du cancer et du sida

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105456553A (zh) * 2014-08-27 2016-04-06 石家庄以岭药业股份有限公司 一种中药组合物在制备治疗眼缺血综合征药物中的应用

Also Published As

Publication number Publication date
US20150190445A1 (en) 2015-07-09
US20110165096A1 (en) 2011-07-07
WO2010019864A2 (fr) 2010-02-18
US9066959B2 (en) 2015-06-30

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