WO2010010412A3 - Procédé de préparation de dérivés de n-méthyl-aryloxy-propanamine - Google Patents

Procédé de préparation de dérivés de n-méthyl-aryloxy-propanamine Download PDF

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Publication number
WO2010010412A3
WO2010010412A3 PCT/HU2009/000063 HU2009000063W WO2010010412A3 WO 2010010412 A3 WO2010010412 A3 WO 2010010412A3 HU 2009000063 W HU2009000063 W HU 2009000063W WO 2010010412 A3 WO2010010412 A3 WO 2010010412A3
Authority
WO
WIPO (PCT)
Prior art keywords
aryloxy
methyl
preparation
propanamine derivatives
propanamine
Prior art date
Application number
PCT/HU2009/000063
Other languages
English (en)
Other versions
WO2010010412A2 (fr
WO2010010412A8 (fr
Inventor
GYÓGYSZERGYÁR Nilvánosan Müködö EGIS
Tibor Mezei
Györgyi KOVÁNYINÉ LAX
József Barkóczy
Baklázs VOLK
Márta PORCS-MAKKAY
Gyula LUKÁCS
Enikö MOLNAR
László Józsefné KOCSIS
Gy]Orgy Krasznai
Imre KÖHEGYI
Judit Broda
Original Assignee
Egis Gyogyszergyar Nilvanosan
Tibor Mezei
Kovanyine Lax Gyoergyi
Barkoczy Jozsef
Volk Baklazs
Porcs-Makkay Marta
Lukacs Gyula
Molnar Enikoe
Kocsis Laszlo Jozsefne
Krasznai Gy Orgy
Koehegyi Imre
Judit Broda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nilvanosan, Tibor Mezei, Kovanyine Lax Gyoergyi, Barkoczy Jozsef, Volk Baklazs, Porcs-Makkay Marta, Lukacs Gyula, Molnar Enikoe, Kocsis Laszlo Jozsefne, Krasznai Gy Orgy, Koehegyi Imre, Judit Broda filed Critical Egis Gyogyszergyar Nilvanosan
Publication of WO2010010412A2 publication Critical patent/WO2010010412A2/fr
Publication of WO2010010412A3 publication Critical patent/WO2010010412A3/fr
Publication of WO2010010412A8 publication Critical patent/WO2010010412A8/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un procédé de préparation de dérivés de N-méthyl-aryloxy-propanamine, ledit procédé comprenant la réaction d’un dérivé d’uréthanne approprié de formule (XXIV) avec un réactif de Grignard.
PCT/HU2009/000063 2008-07-25 2009-07-24 Procédé de préparation de dérivés de n-méthyl-aryloxy-propanamine WO2010010412A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0800467 2008-07-25
HU0800467A HU230480B1 (hu) 2008-07-25 2008-07-25 Eljárás N-metil-ariloxi-propánamin származékok előállítására

Publications (3)

Publication Number Publication Date
WO2010010412A2 WO2010010412A2 (fr) 2010-01-28
WO2010010412A3 true WO2010010412A3 (fr) 2010-05-27
WO2010010412A8 WO2010010412A8 (fr) 2010-07-22

Family

ID=89988421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2009/000063 WO2010010412A2 (fr) 2008-07-25 2009-07-24 Procédé de préparation de dérivés de n-méthyl-aryloxy-propanamine

Country Status (2)

Country Link
HU (1) HU230480B1 (fr)
WO (1) WO2010010412A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104163811A (zh) * 2013-05-16 2014-11-26 重庆圣华曦药业股份有限公司 一种制备度洛西汀盐酸盐的新方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE169819C (fr) *
DE1044103B (de) * 1956-06-12 1958-11-20 Hoffmann La Roche Verfahren zur Herstellung von Xanthen- bzw. Thioxanthenderivaten
US3758620A (en) * 1969-11-06 1973-09-11 Nat Patent Dev Corp Process for the preparation of grignard reagents
EP0273658A1 (fr) * 1986-12-22 1988-07-06 Eli Lilly And Company Propanamines 3-aryloxy-3-substituées
EP0457559A2 (fr) * 1990-05-17 1991-11-21 Eli Lilly And Company Synthèse chirale des 1-aryl-3-aminopropan-1-ols
WO2006071868A2 (fr) * 2004-12-23 2006-07-06 Teva Pharmaceutical Industries Ltd. Processus de preparation de sels de duloxetine repondant aux normes pharmaceutiques et d'intermediaires de ceux-ci

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE169819C (fr) *
DE1044103B (de) * 1956-06-12 1958-11-20 Hoffmann La Roche Verfahren zur Herstellung von Xanthen- bzw. Thioxanthenderivaten
US3758620A (en) * 1969-11-06 1973-09-11 Nat Patent Dev Corp Process for the preparation of grignard reagents
EP0273658A1 (fr) * 1986-12-22 1988-07-06 Eli Lilly And Company Propanamines 3-aryloxy-3-substituées
EP0457559A2 (fr) * 1990-05-17 1991-11-21 Eli Lilly And Company Synthèse chirale des 1-aryl-3-aminopropan-1-ols
WO2006071868A2 (fr) * 2004-12-23 2006-07-06 Teva Pharmaceutical Industries Ltd. Processus de preparation de sels de duloxetine repondant aux normes pharmaceutiques et d'intermediaires de ceux-ci

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MICHEAL, U.; HÖRNFELDT, A.-B.: "N,N-disubstituted carbamates, reagents for the preparation of ketones.", TETRAHEDRON LETTERS, vol. 11, no. 60, 1970, pages 5219 - 5222, XP002559438 *
W. TSCHELINZEFF: "Ueber die Analogie zwischen den organischen Sauerstoff- und Stickstoff-Verbindungen", BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, vol. 37, no. 2, 1904, pages 2081 - 2085, XP002576036, DOI: 10.1002/cber.190403702129 *

Also Published As

Publication number Publication date
HUP0800467A2 (en) 2011-03-28
HU230480B1 (hu) 2016-07-28
HU0800467D0 (en) 2008-10-28
WO2010010412A2 (fr) 2010-01-28
WO2010010412A8 (fr) 2010-07-22

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