WO2010000084A1 - Dispositif d'administration à détecteur générateur - Google Patents

Dispositif d'administration à détecteur générateur Download PDF

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Publication number
WO2010000084A1
WO2010000084A1 PCT/CH2009/000227 CH2009000227W WO2010000084A1 WO 2010000084 A1 WO2010000084 A1 WO 2010000084A1 CH 2009000227 W CH2009000227 W CH 2009000227W WO 2010000084 A1 WO2010000084 A1 WO 2010000084A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
regenerative
administration device
state
injection device
Prior art date
Application number
PCT/CH2009/000227
Other languages
German (de)
English (en)
Inventor
Adrian Eich
Michael Gentz
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Publication of WO2010000084A1 publication Critical patent/WO2010000084A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K35/00—Generators with reciprocating, oscillating or vibrating coil system, magnet, armature or other part of the magnetic circuit
    • H02K35/02—Generators with reciprocating, oscillating or vibrating coil system, magnet, armature or other part of the magnetic circuit with moving magnets and stationary coil systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A61M2205/8212—Internal energy supply devices battery-operated with means or measures taken for minimising energy consumption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8237—Charging means
    • A61M2205/825—Charging means using mechanical generation of electricity, e.g. hand cranked generators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8293—Solar

Definitions

  • the present invention relates to a device for administering or delivering a substance, in particular an injection device or a pen or an infusion device, which has a metering element for the metered administration of an injectable product, which can interact with an electronic controller.
  • An injection device is preferably used for self-administration of the product, for example as a reusable or disposable injector, which can be used, for example, with a simple or Zweischam- pulle.
  • Injection pens are widely used for self-administration of drugs because of their easy-to-handle form.
  • a drug such as insulin, or a hormone
  • the simple safety in handling for example, the setting of the dosage and in particular the correct detection and display of the set dose of great importance.
  • Infusion devices are z. B. to the most uniform possible delivery of a substance such. B insulin, although larger doses can be given in case of need.
  • an injection device usually also electronic components are provided, for example, for detecting, monitoring and / or displaying a setting movement, in such an injection device and a battery, for example in the form of a button cell is used.
  • a battery is present in an infusion device.
  • the electronics within the injection pen or the infusion device should be used for as long as possible. ge operating time be designed so that the electronics should be designed very energy efficient.
  • the injection device may be designed so that the electronic system remains as often as possible in one or more operating states in which the electronics require very little energy and, for example, as far as possible is inactive.
  • the electronics can be activated at any time if required, wherein an activation of the electronics can be effected for example by means of an electromechanical switching contact, which closes a circuit, as shown for example in FIG.
  • a control I 5 which can be automatically brought to a standby state or switched off, for example, by a timer or a timer, is connected to a battery 2 and is realized, for example, with energy-saving CMOS technology.
  • the controller 1 flows through the controller 1 in the activated or operating state of the operating current i ß , which is usually much greater than the quiescent current io in the idle state, which should be as close as possible to 0 in order to realize the longest possible operation of the overall circuit.
  • controller 1 For activating the, for example, in the idle state controller 1 may be provided, for example, acted upon by a spring force mechanical switch 3, which direction of a movable part 4 of the Injetationsvor-, such as an adjustment or a threaded rod, for example, carries cams , can be closed to activate the controller 1, which, for example, can turn on an LCD display and then indicate the dose to be set or set.
  • the closing of the switch 3 is detected by the circuit 1, for example via a measurement of the current flow i 2 or by measuring the voltage Us.
  • a current I 1 still flows approximately in the magnitude of the current I 2 , which shortens the service life of the battery 2. Care must also be taken in the circuit variant shown in FIG.
  • the switch 3 is securely opened in the desired rest state of the electronics, wherein with respect to the movable element 4 of the injection device, preferably constructive measures are to be taken and / or the user or the medical To instruct personnel to keep the administration device in its intended condition after use to prevent the battery from being unnecessarily discharged.
  • the switch 3 is closed, a current flows through the closed switch, which current loads the battery 2 and thus further shortens its service life.
  • the smallest possible switch current should be set by means of the largest possible series resistor R.
  • the switch current must not be too small, since otherwise the susceptibility to interference, for example, by electromagnetic or electrostatic (EMC, ESD) influences is too large.
  • FIG. 5a Another conceivable variant of an administration device control is shown in FIG. 5a, wherein the controller 1 is connected to an eg contactless sensor or detector 5, which can detect, for example, an electric or magnetic field or light or another physical property change.
  • an eg contactless sensor or detector 5 which can detect, for example, an electric or magnetic field or light or another physical property change.
  • a continuous current flow I 1 and often also an amplifier is required, which also shortens the life of the battery 2.
  • the senor 5 via a switching means 3 a, which is advantageously controlled by the controller 1, switched on or off, which preferably takes place periodically in such a way that follows a short switch-on a long turn-off.
  • the resulting mean value of the current ⁇ is small compared to the value in continuous operation corresponding to the switching ratio, which protects the battery.
  • security is to be provided against unnecessary discharging of the battery, or the battery may be omitted under certain circumstances, and the movements to be detected are detected in a timely and sufficiently accurate manner.
  • An administration device ie z.
  • an injection device or Infusionsvorrich- device comprises at least one regenerative sensor to detect the change in at least one state of Inj etechnischs device, which in the context of the invention under a generator sensor, a sensor to be understood, which no power supply or no Requires quiescent current and independently, for example, electrical energy, such as a voltage or current flow can generate.
  • the acting as an active voltage source, or power source, for example, regenerative sensors can thus be used in an injection device without a current from the power supply or battery of the injection device to need, which increases the life of the battery and thus the entire injection device.
  • generator sensors without loading the battery, be continuously in operation. This allows a controller to be activated asynchronously and without delay.
  • the regenerative sensor can be used as an activation switch to recognize, for example, by monitoring the movement of a setting element or by detecting a vibration or movement of the injection device itself, that the control should be activated and, for example, a display activated or turned on.
  • a regenerative sensor may also be used as a stop sensor to detect whether a movable member, such as a piston or threaded rod, or a dose setting means has been moved or translated to a desired position.
  • the regenerative sensor can also be used as a rotation sensor in order to detect the rotation and / or position of, for example, an adjusting element, a threaded rod or a rotatable sleeve of the injection device.
  • the regenerative sensor can also be used as a displacement sensor to detect the translation and / or position of an adjusting element, a threaded rod or a rotatable sleeve of the injection device.
  • the regenerative sensor can also be used as a reset switch to detect a reset of the injection device, for example by turning back the adjustment or pressing a reset button.
  • two or more regenerative sensors with the same or different functions can also be used in an application device.
  • one or more regenerative sensors are used in the injection device, which are connected, for example, with one or more movable, ie for example rotatable and / or displaceable, components of the injection device, coupled or can monitor them.
  • one or more regenerative sensors may interact with an adjustment member, such as a knob or rotary ring, a trigger member such as a push button, or a mechanical member, for example, inside the injection device, such as a piston or threaded rod
  • the controller can store the information and / or display on a display, with stored information can be read out, for example, in a check or control by the user or by medical personnel from the controller or a memory.
  • a pulse-wire sensor and in particular a W ⁇ egand sensor can be used with which magnetic fields can be detected.
  • one or more permanent magnets may be connected to at least one of the above-mentioned movable parts of the administering device.
  • a Wiegand sensor a Wiegand wire made of an alloy with a hard magnetic metal as a sheath and a soft magnetic metal as a core is provided, reference being made to the structure and the functioning of a Wiegand sensor to the teaching of WO 00/17997, which is included in this application.
  • WO 2004/046735 A1 which is likewise included in this application.
  • the design of the regenerative sensor is advantageous as a Wiegand sensor, as a non-contact active without active power sensor can be realized thereby. Irrespective of a speed of movement or revolution of one or more components monitored by the Wiegand sensor, a single-touch sensor can be used to achieve a clean switching operation, which can be easily and clearly detected by a controller pulse generated by the Wiegand sensor, which unlike a mechanical switch also has no bouncing, a unique activation signal is obtained.
  • a Wiegand sensor is suitable for constructing an encoder in order, for example, to detect rotational movements in the case of metering or discharge. The signal output from the Wiegand sensor does not require any special signal conditioning other than pulse shaping or pulse conversion.
  • Wiegand sensor is advantageous because a pulse can be generated even with a slow motion.
  • a photocell or solar cell can be used as a regenerative sensor, which can convert an incident light into electrical energy and preferably converts the energy supplied by electromagnetic radiation by generating free charge carriers into electrical energy.
  • a piezoelectric element as a generator-type sensor, wherein at least one piezoelectric element can be deformed by a movement of an element of the injection device in such a way that electrical energy is generated in order, for example, to control and / or display an injection device in an active state staggered.
  • an induction sensor can be used as a generator sensor, which from the movement of a, for example, connected to a permanent magnet relative to Induction sensor movable part generates a voltage that is used to activate or operate the controller.
  • the regenerative sensor is used as a non-contact sensor and realized, for example, in the function of a non-contact switch.
  • the regenerative sensor is preferably not touched by a movable part of the injection device in a change of state of the movable part and for example by one or more attached to the movable member permanent magnets or other non-contact mechanisms, such as electromagnetic radiation or light activated and stimulated to generate electrical energy.
  • a non-contact switch is advantageous since, in contrast to mechanical switches, no impairment of the contacts can occur, for example due to wear, corrosion, sticking or breaking.
  • non-contact sensors or switches can be flexibly installed in an injection device, whereby frequently no narrow mechanical tolerances are to be maintained.
  • the energy generated by the regenerative sensor is used not only for detecting a state change, but also for operating and / or activating a circuit or the control or display of the injection device.
  • the electrical energy generated by the regenerative sensor can be used for example for a short-term power supply of an evaluation circuit, for example, to realize a quantitative detection and storage of discharges without batteries.
  • These recorded distribution processes can, for example, be stored non-volatilely in a counter and used by a physician for therapy monitoring or generally also for lifetime testing.
  • an energy storage device comprising at least one capacitor coupled to the regenerative sensor to store an electrical energy generated by the regenerative sensor for immediate or later use, for example by a circuit or controller.
  • the invention relates to a method for detecting a change in at least one state of an injection device, wherein a regenerative sensor is used as a detector, which cooperates with at least one element or a component of the injection device.
  • Figure 1 a is a circuit diagram of a first embodiment of the invention
  • Figure Ib A circuit diagram of a second embodiment of the invention
  • Figure 3 shows the schematic structure of a position detector using a
  • Figure 4 shows a circuit arrangement for monitoring the state of an injection device
  • FIG. 5a shows an alternative circuit arrangement for monitoring an injection device
  • FIG. 5b shows another alternative circuit arrangement for monitoring an injection device with means for non-continuous operation
  • Figure 6 shows an embodiment of the invention with a regenerative sensor in a Inj edictions device in rest position and;
  • FIG. 1 shows a controller 1 provided in an injection apparatus which is supplied by a battery 2 with a current i 0 flowing in the idle state and current i ß flowing in the operating state.
  • a regenerative sensor 6 is connected to the controller, which receives no power from the battery 2 and thus does not load the battery 2.
  • the regenerative sensor 6 may be coupled to or cooperate with a movable, for example, in the circumferential direction alternately magnetized part 4 of the injection device and preferably produces a change in the position or position of the preferably moving part 4 of the injection device monitored by the regenerative sensor 6 electrical signal which is supplied to the controller 1, wherein the electrical energy of the signal generated by the generator sensor 6 can also be stored in the optional predictable capacitor C, which can also be omitted, as an energy storage device 8, to power the controller 1 even after the occurrence of the signal from the active sensor 6 to be able to continue to relieve the battery 2 or to make superfluous, as shown in Figure Ib.
  • the regenerative sensor 6 unlike in FIGS. 4 and 5, does not require a current ii from the battery 2, the battery 2 can be relieved and thus the service life extended, wherein in the idle state preferably only the current i 0 flows through the controller 1, which in the ideal case can also be 0.
  • FIG. 2 shows an embodiment of the invention in which the regenerative sensor 6 is designed as a Wiegand sensor 6.
  • Permanent magnets 7A and 7B and optionally further permanent magnets which are arranged for example on, on or in a relative to the sensor 6 movable part are with the moving past the Wiegand sensor 6 part of the injection device, for example on an inner side or outer side of a rotary knob or a threaded rod, wherein preferably in the rotational or circumferential direction adjacent permanent magnets have a reverse polarity, so that upon movement of the respective permanent magnet 7 on the Wiegand sensor 6 over the position of the north pole and south pole S with respect to the adjacent and, for example, before or after passing permanent magnet 7 is reversed.
  • only a single permanent magnet with two or a plurality of poles may be arranged on a movable part.
  • a magnetic field B is generated which acts on the Wiegand wire within the Wiegand sensor 6, so that the soft magnetic core and the hard magnetic cladding of the Wiegand wire is or are magnetized in the same direction.
  • the permanent magnet 7A is moved from the Wiegand sensor 6 and the permanent magnet 7B to the Wiegand sensor 6, the permanent magnet 7B being polarized reversely like the permanent magnet 7A.
  • the permanent magnet 7B leads to the formation of a magnet netfeldes B in the reverse direction compared to the magnetic field formed by the permanent magnet 7 A B 5 so that the core of the Wiegand wire within the Wiegand sensor 6 changes its direction of magnetization or reversed, which relate due to this switching process an output pulse at the two terminals - Is generated between the poles 6-1 and 6-2 of the Wiegand sensor 6. If the permanent magnet 7B continues to approach the Wiegand sensor 6, the magnetization of the jacket of the Wiegand wire is also reversed given a corresponding magnetic field strength B, so that the core and cladding of the Wiegand sensor are again polarized in the same but opposite direction.
  • This process of re-polarization and pulse generation of the Wiegand sensor is repeated with reversed polarity when a permanent magnet 7B following the permanent magnet with reversed polarization is moved towards the Wiegand sensor 6.
  • the polarization of the cladding of the Wiegand sensor 6 can also remain constant in the same direction and, due to the appropriate sequence and field strength of the magnetic field B, only the core of the Wiegand sensor 6 can be reversed.
  • the electrical energy generated by the Wiegand sensor 6 can be used to activate the control shown in Figure 1 and to charge the energy storage device, for. B. of the capacitor 8 can be used.
  • the moving body is, for example, a threaded rod 10 which can rotate in the direction of the arrows R1 and R2, that is to say in the clockwise or counterclockwise direction.
  • the threaded rod 10 In order to count the rotations of the threaded rod 10, is arranged on or in this a north pole N and a south pole S exhibiting excitation magnet EM.
  • the ferromagnetic flux guide pieces FL1 and FL2, whose ends 14 and 15 lie on the circular arc described by the excitation magnet EM and whose ends 16 and 17 face the end faces of a ferromagnetic element FE, can influence the ferromagnetic element FE by the magnetic field generated by the excitation magnet EM become.
  • the ferromagnetic element FE is preferably an impulse wire.
  • the aligned parallel to the direction of movement of the field magnet EM ferromagnetic element FE is surrounded by at least one sensor coil SP, at the output terminals 6-1, 6-2 the voltage pulses of corresponding polarity generated when passing through the excitation magnet EM due to remagnetization of the ferromagnetic element FE are removable.
  • sensors 18, z As a Hall sensor, light sensors, strain gauges (DMS), switches, contacts, capacitive sensors, potentiometers, encoders or other sensors qualitatively and quantitatively improve or supplement the information provided by the generator sensor 6, ie z. B. measure the direction of rotation, the angle of rotation and / or the speed.
  • FIG. 6 shows the proximal part of an injection device and in particular the metering mechanism in the rest position with a pressed-in dispensing or metering button 13.
  • Magnet rings 16a, 16b are provided on the sleeve connected to the dispensing or metering button 13, wherein in the position shown in FIG the proximal magnetic ring 16b is axially spaced from the Wiegand sensors 11, 12.
  • the Wiegand sensors 11, 12 are connected to the controller and display 10, in which a battery 2 is inserted.
  • FIG. 7 shows the device shown in FIG. 6 in the working position with the dispensing or dispensing button 13 released in the proximal direction.
  • the magnetic rings 16a, 16b have been displaced in the axial direction, so that the magnetic ring 16a is no longer the magnetic ring 16b , the Wiegand sensors 11, 12 opposite. If the magnet rings 16a and 16b differ in their polarity, then a change of the magnetic field acting on the Wiegand sensors 11, 12 occurs, and a current can be generated by the Wiegand sensors 11, 12 to supply the circuit activate and z.
  • B. charge an energy storage device 8.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Power Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'administration comprenant un détecteur (6), destiné à détecter une variation d'au moins un état du dispositif d'injection, caractérisé en ce que le détecteur est un détecteur générateur. L'invention concerne également un procédé de détection d'une variation, d'au moins un état, d'un dispositif d'administration, caractérisé en ce qu'on utilise, en tant que détecteur, un ou plusieurs détecteurs générateurs, lesquels coopèrent avec au moins un élément ou un composant du dispositif d'injection.
PCT/CH2009/000227 2008-07-04 2009-07-01 Dispositif d'administration à détecteur générateur WO2010000084A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200810031795 DE102008031795A1 (de) 2008-07-04 2008-07-04 Verabreichungsvorrichtung mit generatorischem Sensor
DE102008031795.0 2008-07-04

Publications (1)

Publication Number Publication Date
WO2010000084A1 true WO2010000084A1 (fr) 2010-01-07

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PCT/CH2009/000227 WO2010000084A1 (fr) 2008-07-04 2009-07-01 Dispositif d'administration à détecteur générateur

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DE (1) DE102008031795A1 (fr)
WO (1) WO2010000084A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014067879A1 (fr) * 2012-10-29 2014-05-08 Sanofi-Aventis Deutschland Gmbh Dispositif de distribution de médicaments ayant un récipient de médicaments comprenant un capteur et un système de transmission de données optiques
US9569939B2 (en) 2012-10-08 2017-02-14 Oechsler Aktiengesellschaft Event detector and medicament dispenser having such an event detector
WO2017081051A1 (fr) * 2015-11-11 2017-05-18 Novo Nordisk A/S Dispositif d'administration de médicament avec capture d'informations

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559629B2 (en) 2017-12-21 2023-01-24 Sanofi Determining a status of an injection
WO2020035217A1 (fr) * 2018-08-16 2020-02-20 Haselmeier Ag Dispositifs médicaux adaptés aux microfils

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WO2000017997A1 (fr) * 1998-09-24 2000-03-30 Hid Corporation Generateur d'energie par effet wiegand
WO2004046735A1 (fr) * 2002-11-20 2004-06-03 Walter Mehnert Detecteur de position
US20060147324A1 (en) * 2004-12-30 2006-07-06 Par Technologies Method and apparatus for scavenging energy during pump operation
DE102005059508A1 (de) * 2005-12-13 2007-06-14 Tecpharma Licensing Ag Stromerzeugender Pen

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Publication number Priority date Publication date Assignee Title
US7070577B1 (en) 1998-02-02 2006-07-04 Medtronic, Inc Drive circuit having improved energy efficiency for implantable beneficial agent infusion or delivery device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017997A1 (fr) * 1998-09-24 2000-03-30 Hid Corporation Generateur d'energie par effet wiegand
WO2004046735A1 (fr) * 2002-11-20 2004-06-03 Walter Mehnert Detecteur de position
US20060147324A1 (en) * 2004-12-30 2006-07-06 Par Technologies Method and apparatus for scavenging energy during pump operation
DE102005059508A1 (de) * 2005-12-13 2007-06-14 Tecpharma Licensing Ag Stromerzeugender Pen

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9569939B2 (en) 2012-10-08 2017-02-14 Oechsler Aktiengesellschaft Event detector and medicament dispenser having such an event detector
WO2014067879A1 (fr) * 2012-10-29 2014-05-08 Sanofi-Aventis Deutschland Gmbh Dispositif de distribution de médicaments ayant un récipient de médicaments comprenant un capteur et un système de transmission de données optiques
CN104755118A (zh) * 2012-10-29 2015-07-01 赛诺菲-安万特德国有限公司 具有包括传感器和光数据传输系统的药物容器的药物输送装置
CN104755118B (zh) * 2012-10-29 2018-05-01 赛诺菲-安万特德国有限公司 具有包括传感器和光数据传输系统的药物容器的药物输送装置
US10092697B2 (en) 2012-10-29 2018-10-09 Sanofi-Aventis Deutschland Gmbh Drug delivery device with drug container comprising a sensor and optical data transmission system
WO2017081051A1 (fr) * 2015-11-11 2017-05-18 Novo Nordisk A/S Dispositif d'administration de médicament avec capture d'informations
CN108348695A (zh) * 2015-11-11 2018-07-31 诺和诺德股份有限公司 具有信息捕获的药物输送装置
US10850041B2 (en) 2015-11-11 2020-12-01 Novo Nordisk A/S Drug delivery device with information capture

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