WO2009144977A1 - Composition orale pour la pousse des cheveux - Google Patents

Composition orale pour la pousse des cheveux Download PDF

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Publication number
WO2009144977A1
WO2009144977A1 PCT/JP2009/053091 JP2009053091W WO2009144977A1 WO 2009144977 A1 WO2009144977 A1 WO 2009144977A1 JP 2009053091 W JP2009053091 W JP 2009053091W WO 2009144977 A1 WO2009144977 A1 WO 2009144977A1
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WO
WIPO (PCT)
Prior art keywords
hair
composition
sialic acid
oral
hair growth
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PCT/JP2009/053091
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English (en)
Japanese (ja)
Inventor
研二 岡嶋
直明 原田
信也 山口
泰弘 太田
Original Assignee
ジャパン・フード＆リカー・アライアンス株式会社
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Publication date
Application filed by ジャパン・フード＆リカー・アライアンス株式会社 filed Critical ジャパン・フード＆リカー・アライアンス株式会社
Priority to JP2010514394A priority Critical patent/JPWO2009144977A1/ja
Publication of WO2009144977A1 publication Critical patent/WO2009144977A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • the present invention relates to a composition for oral hair restoration.
  • this invention relates to the composition for oral hair growth which contains sialic acid as an active ingredient and has a hair growth effect.
  • hair growth agents have been developed so far, most of which are rubbed into the scalp and gained its effectiveness through penetration from the scalp. Such a usage method is difficult to use easily and makes it difficult to continue using it. In addition, many of them are traded at a high price, which places a burden on the therapist in terms of cost.
  • a hair growth agent that is orally administered or ingested has also been developed.
  • anti-hair loss symptom food and drink containing oolong tea extract containing oolong tea extract
  • oral anti-hair loss symptom agent Patent Document 1
  • hair growth food containing proanthocyanidins Patent Document 2
  • Non-patent Document 3 capsaicin is a substance that temporarily gives severe irritation to the digestive organs such as the stomach and esophagus, and depending on the person, the digestive organs such as the stomach may be affected by ingestion.
  • capsaicin is a substance that temporarily gives severe irritation to the digestive organs such as the stomach and esophagus, and depending on the person, the digestive organs such as the stomach may be affected by ingestion.
  • due to the stimulation there is a problem that it is difficult to ingest unless it is ingested with a large amount of water.
  • JP-A-9-309840 Japanese Patent Laid-Open No. 2000-201650 Japanese Patent Laying-Open No. 2005-068129 Naoaki Harada et al., Growth Hormone & IGF Research 17 (2007) 408-415
  • An object of the present invention is to provide an oral hair-growth composition that has an excellent hair-growth effect and does not cause intense irritation to the digestive organs upon administration or ingestion.
  • the present inventors can obtain an excellent hair-growth effect by oral administration or ingestion of sialic acid, and are accompanied by irritation to the digestive organs even when oral administration or ingestion of sialic acid.
  • the inventors have found that the present invention can solve the above-mentioned problems.
  • the present invention includes the following oral hair restoration compositions, hair restoration methods, oral hair restoration agents and the like according to items 1 to 19 below.
  • Item 1. An oral hair restoration composition comprising sialic acid and a pharmaceutically acceptable or ingestible carrier.
  • Item 2. The composition for oral hair restoration according to Item 1, wherein the sialic acid is N-acetylneuraminic acid.
  • Item 3. The composition for oral hair restoration according to Item 1 or 2, comprising 0.1 to 95% by weight of sialic acid.
  • Item 4. Item 4. The composition for oral hair restoration according to any one of Items 1 to 3, which is administered or ingested in an amount of 0.01 to 1000 mg / kg (body weight) per day for an adult.
  • Item 5. Item 5.
  • Item 5. The composition for oral hair restoration according to any one of Items 1 to 4, which is a food composition.
  • Item 7. A method for hair growth comprising the step of orally administering or ingesting a person who desires hair growth with an amount of sialic acid effective for hair growth.
  • Item 8. The hair growth method according to Item 7, wherein the sialic acid is N-acetylneuraminic acid.
  • sialic acid is administered or ingested in an amount of 0.01 to 1000 mg / kg (body weight) per day.
  • Item 10. Use of sialic acid for the production of a composition for oral hair restoration.
  • Item 11. Item 11. The use according to Item 10, wherein the sialic acid is N-acetylneuraminic acid.
  • Item 12. Sialic acid for hair growth by oral administration or ingestion.
  • Item 13. N-acetylneuraminic acid for hair growth by oral administration or ingestion.
  • Item 14. Item 5. The oral hair growth composition according to any one of Items 1 to 4, which is a food additive for hair growth.
  • Item 16. Item 16.
  • Item 17. Item 17.
  • Item 18. An oral hair restorer comprising a food composition containing sialic acid.
  • Item 19. An oral hair restorer comprising a food composition containing sialic acid.
  • CGRP calcitonin gene-related peptide
  • IGF-I insulin-like growth factor-I
  • an oral hair growth composition an oral hair growth agent, and a hair growth method that have an excellent hair growth effect and that do not cause irritation to the digestive organs by oral administration or ingestion.
  • the hair-growth effect refers to the effect of growing hair, and the effect of growing hair such as thickening, lengthening, strengthening, making it difficult to remove, and growing (stretching) the hair.
  • the present invention is particularly excellent in the effect of growing hair.
  • composition for oral hair restoration according to the present invention is characterized by containing sialic acid as an active ingredient.
  • Sialic acid is a generic name for substances in which the amino group or hydroxy group of neuraminic acid is substituted.
  • the sialic acid used in the composition for oral hair restoration according to the present invention may be naturally derived or chemically synthesized.
  • naturally-derived materials not only purified products but also crude products can be used as long as the effects of the present invention can be obtained.
  • Examples of naturally derived substances containing a large amount of sialic acid include axilla, milk, egg yolk and the like, and axilla is particularly preferable because of its high sialic acid content.
  • milk and egg yolk are preferable from the ease of acquisition.
  • Sialic acid can also be produced by, for example, an enzyme synthesis method using glucosamine as a raw material, a genetic engineering method using Escherichia coli, or the like, and these can also be used in the present invention.
  • sialic acids can be used singly or in appropriate combination of two or more.
  • composition for oral hair restoration according to the present invention contains, in addition to sialic acid, a pharmaceutically acceptable carrier or an ingestible carrier.
  • the amount of sialic acid can be appropriately set according to the daily administration or intake amount, etc., but is preferably 0.01 to 99% by weight, more preferably 0.1 to 95% by weight based on the whole composition. 1 to 90% by weight is more preferable.
  • the composition for oral hair restoration according to the present invention has an effect of inducing the release of calcitonin gene-related peptide (CGRP) and promoting the production of IGF-I within a range not losing the effects of the present invention. May be combined with sialic acid.
  • IGF-I production promoting component include capsaicin, isoflavone, raspberry ketone, capsiate, honey, royal jelly, and the like. Among these, isoflavone is preferable.
  • the compounding amount of the IGF-I production promoting component can be appropriately set according to the form of the oral hair growth composition according to the present application, the daily administration or intake amount, and the like.
  • an IGF-I production promoting component By blending an IGF-I production promoting component, a synergistic hair growth effect with sialic acid can be expected. In particular, those blended at a ratio of 0.25 to 0.75 parts by weight of isoflavone to 1 part by weight of sialic acid are preferred, and those blended at 0.5 parts by weight are particularly preferred.
  • the IGF-I production promoting component can be used alone or in combination of two or more in combination with sialic acid.
  • composition for oral hair restoration according to the present invention, a pharmaceutically acceptable or ingestible carrier can be blended within a range that does not impair the effects of the present invention.
  • Examples of pharmaceutically acceptable carriers include excipients, diluents, binders, disintegrants, stabilizers, absorption promoters, humectants, adsorbents, lubricants, and the like. Moreover, these agents can be illustrated as an ingestible carrier, for example. These carriers can be used singly or in appropriate combination of two or more.
  • the fluorescent hair-growth composition according to the present invention can be blended with optional components as long as the effects of the present invention are not impaired.
  • Such ingredients include, for example, antioxidants, coloring agents, sugar coatings, coating agents, pH regulators, emulsifiers, preservatives, sweeteners, preservatives, chewing agents, cooling agents, feeding accelerators, potentiators. Examples thereof include a sticky agent, a fragrance, a dispersant, and a miso odorant.
  • optional components can be used singly or in appropriate combination of two or more.
  • the oral hair growth composition according to the present invention is preferably, for example, a pharmaceutical composition or a food composition.
  • the carrier to be blended is preferably pharmaceutically acceptable.
  • the carrier is pharmaceutically acceptable or ingestible. Preferably there is.
  • the shape of the composition for oral hair restoration according to the present invention is not particularly limited as long as it can be administered orally.
  • it can be used as a liquid solution or as a solid tablet, powder, granule, powder or the like.
  • such an oral hair growth composition can be used as a pharmaceutical composition or a food composition for hair growth.
  • it can utilize also as a food additive for hair growth used by adding to food.
  • the amount added to the food is appropriately set, and the food added with the food additive is eaten. Ingest.
  • the said addition may be performed during food preparation or manufacture, and may be performed when eating the cooked food.
  • Examples of such food additives include, but are not limited to, liquids, powders, flakes, granules, and pastes.
  • composition for oral hair restoration according to the present invention is a food composition
  • ingredients used as food may be blended within a range that does not impair the effects of the present invention. it can.
  • the food composition include sialic acid-containing foods such as axilla, milk and egg yolk, various foods artificially containing sialic acid, and food compositions produced using these.
  • the kind of food composition of this invention is not specifically limited, For example, drinks, confectionery (for example, gum, chocolate, candy, biscuits, cookies, rice crackers, rice crackers, etc.), breads, soups (powder soup, etc.) Etc.) can be exemplified.
  • the food composition of the present invention can also be prepared as health foods (nutrient functional foods, foods for specified health use, etc.), supplements, foods for the sick, etc. for hair growth purposes.
  • health foods nutrient functional foods, foods for specified health use, etc.
  • supplements foods for the sick, etc. for hair growth purposes.
  • the food composition of the present invention in order to facilitate continuous intake, for example, in the form of granules, capsules, tablets (including chewable agents), beverages (drinks), etc. It is desirable to prepare, and in particular, capsules, tablets, and tablets are preferable from the viewpoint of easy intake, but are not particularly limited thereto.
  • the food and beverage composition of the present invention in the form of capsules and tablets can be appropriately prepared according to a conventional method using the pharmaceutically acceptable carrier. Moreover, even if it is a case where it prepares in another form, what is necessary is just to follow the conventional method.
  • the composition for oral hair restoration according to the present invention can be administered or ingested for the purpose of hair restoration.
  • humans who desire hair growth can be suitably used.
  • humans who desire hair growth include those who suffer from hair loss and thinning hair, those who suffer from hair-related diseases such as alopecia, and those who have hair loss due to side effects of drugs.
  • humans who desire further hair growth and hair growth can also be used without worrying about these symptoms.
  • it can be applied not only to humans but also to pets, livestock and the like for which hair growth is desired. In this case, it can be used as a hair growth additive for pets and livestock medicines, solid and powdered feeds, and the like.
  • the effective administration or intake for hair restoration of the composition for oral hair restoration according to the present invention is preferably 0.01 to 1000 mg / kg (body weight) / day in terms of sialic acid when used by an adult, and 0.1 to 100 mg. / kg (weight) / day is more preferable.
  • the composition for oral hair restoration can be administered or ingested once or twice a day, and is preferably administered or ingested 1 to 3 times a day.
  • the administration or intake of a child or pet who desires hair growth can be appropriately set according to the shape of the agent, the strength of the effect, and the like.
  • the present invention also provides an oral hair restorer containing sialic acid as an active ingredient.
  • the oral hair restorer can take, for example, the same form as that of the aforementioned oral hair restorer composition. Moreover, the said oral hair restorer may consist only of sialic acid.
  • the present invention also provides a hair-growth method characterized by orally administering or ingesting sialic acid to a human suffering from hair loss or thinning hair, or a human who desires hair growth. Specifically, this method is carried out by administering or ingesting the above-mentioned composition for oral hair restoration.
  • each condition such as the type of sialic acid, oral administration or intake is as described above.
  • Test Example 1 Preparation of mouse dorsal root ganglion cells (DRG) 6- to 8-week-old C57BL / 6 male mice (Japan SLC) were prepared to be ketalal 100 mg / kg and xylazine 10 mg / kg. The mixture was administered intraperitoneally and anesthetized. The cervical vertebrae to lumbar vertebrae were removed, separated in the midline, and bilateral DRGs were collected.
  • DRG mouse dorsal root ganglion cells
  • the extracted DRG is put in 1.6 ml collagenase II (manufactured by GIBCO), 100 U / ml dispase I (manufactured by Godo Shusei), and 5% fetal bovine serum (FBS) -containing Minimum Essential Medium (manufactured by GIBCO) It was left overnight at 37 ° C., 5% CO 2 . After completion, the mixture was centrifuged at 3000 rpm and 25 ° C. for 5 minutes, and the supernatant was discarded. A nutrient solution having the following composition was added to the cells, stirred uniformly, and then cultured for 7 days at 37 ° C. and 5% CO 2 using a 35 mm dish (manufactured by BD Japan) coated with collagen I.
  • DMEM / F-12 medium Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 mixed 1: 1) containing the following was used as a nutrient solution.
  • Test Example 2 Effect of sialic acid on CGRP release from mouse dorsal root ganglion cells (DRG) After culturing DRG for 7 days as described in Test Example 1, the nutrient solution was discarded on the 7th day of culture, Replaced with DMEM / F-12 containing 1% FBS. N-acetylneuraminic acid (manufactured by Japan Food & Liquor Alliance) prepared so as to have final concentrations of 1, 10 and 100 mM was added thereto and left at 37 ° C. and 5% CO 2 for 30 minutes. After completion, the culture supernatant was collected and stored at -20 ° C. The CGRP concentration in the culture supernatant was measured using an ELISA kit (manufactured by SPI bio). The results are shown in FIG.
  • DRG mouse dorsal root ganglion cells
  • N-acetylneuraminic acid has an action of stimulating sensory nerves and releasing CGRP. It was also found that the higher the concentration of N-acetylneuraminic acid, the greater the amount of CGRP released (p ⁇ 0.01).
  • composition for oral hair restoration according to the present application can be obtained by the production and release of CGRP.
  • Test Example 3 Hair growth effect of sialic acid 6-week-old C57BL / 6 male mice (Japan SLC) were administered intraperitoneally with a mixture prepared to give ketalal 100 mg / kg and xylazine 10 mg / kg After anesthesia, the back was shaved with a size of 2 ⁇ 4 cm. Next, N-acetylneuraminic acid was dissolved in physiological saline so as to be 0.25 mg / ml and 0.5 mg / ml.
  • mice forcibly administered once a day into the stomach of the aforementioned shaved mouse using a gastric sonde so as to be 0.1 ml per 10 g of body weight ie, the final dose was 2.5 mg / kg / day and 5 mg / day). kg / day).
  • the control shaved mouse was administered with physiological saline so as to be 0.1 ml per 10 g of body weight.
  • mice forcibly administered with these N-acetylneuraminic acids and the control mice forcibly administered with only saline were bred under the following conditions except for the forcible administration.
  • the control mice have almost no hair on the shaved part, whereas the N-acetylneuraminic acid 2.5 mg / kg / day group has some hair and has a shaved part. Furthermore, in the 5 mg / kg / day administration group, hair was grown to such an extent that the shaved portion was hardly visible.
  • Test Example 4 Effect of sialic acid on mouse skin calcitonin gene-related peptide (CGRP) and insulin-like growth factor-I (IGF-I) concentrations ⁇ Skin sample collection> N-acetylneuraminic acid was dissolved in physiological saline to a concentration of 0.5 mg / ml. Then, using a gastric sonde, this was forcibly administered once a day into the stomach of 6 to 8 week old C57BL / 6 male mice (5 mice) to 0.1 ml per 10 g of body weight (ie, the final dose was 5 mg / kg / day). Similarly, physiological saline was administered to the control group so as to be 0.1 ml per 10 g of body weight (5 animals).
  • CGRP mouse skin calcitonin gene-related peptide
  • IGF-I insulin-like growth factor-I
  • mice forcibly administered with these N-acetylneuraminic acids and the control mice forcibly administered with only saline were bred under the conditions shown in Test Example 3 except for the forcible administration.
  • the skin CGRP concentration in the N-acetylneuraminic acid administration group is about 2.5 times that of the control group, and the skin IGF-I concentration is about 3 times that of the control group. became.
  • both the skin CGRP concentration and the skin IGF-I concentration were significantly higher in the N-acetylneuraminic acid administration group (p ⁇ 0.01).

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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Abstract

La présente invention concerne une composition orale qui présente une excellente efficacité pour la pousse des cheveux et pour laquelle l’administration ou l’ingestion n’est pas accompagnée d’une irritation sévère du tube digestif. L’invention concerne une composition orale pour la pousse des cheveux qui renferme de l’acide sialique et un support pharmacologiquement permissible et ingérable.
PCT/JP2009/053091 2008-05-28 2009-02-20 Composition orale pour la pousse des cheveux WO2009144977A1 (fr)

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JP2010514394A JPWO2009144977A1 (ja) 2008-05-28 2009-02-20 経口育毛用組成物

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JP2008139525 2008-05-28
JP2008-139525 2008-05-28

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WO2009144977A1 true WO2009144977A1 (fr) 2009-12-03

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522234A (ja) * 2010-03-12 2013-06-13 ディーエスエム アイピー アセッツ ビー．ブイ． 母体へのシアル酸補給
CN104146885A (zh) * 2014-07-14 2014-11-19 武汉中科光谷绿色生物技术有限公司 N-乙酰神经氨酸水合物在育发产品中的应用
KR20170045275A (ko) * 2014-10-31 2017-04-26 가부시키 가이샤 파마푸즈 발모 및 육모 촉진제 및 이들의 이용

Citations (3)

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JPH08119986A (ja) * 1994-10-25 1996-05-14 Nissin Food Prod Co Ltd シアル酸またはその類縁体の精製方法
JP2001192393A (ja) * 2000-01-07 2001-07-17 Morinaga Milk Ind Co Ltd 内在性シアリダーゼ耐性ラクトン体含有組成物
JP2009073806A (ja) * 2007-08-27 2009-04-09 Iriya Cosmetics Co Ltd インスリン様成長因子−１分泌促進剤

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JP2555389B2 (ja) * 1987-12-21 1996-11-20 雪印乳業株式会社 養毛剤
JP2006197914A (ja) * 2005-01-21 2006-08-03 Takeshi Inaba 燕の巣入り飴及び燕の巣を混入した飴の製造方法
EP2157870A1 (fr) * 2007-06-25 2010-03-03 DSM IP Assets B.V. Nouveaux prébiotiques

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Publication number Priority date Publication date Assignee Title
JPH08119986A (ja) * 1994-10-25 1996-05-14 Nissin Food Prod Co Ltd シアル酸またはその類縁体の精製方法
JP2001192393A (ja) * 2000-01-07 2001-07-17 Morinaga Milk Ind Co Ltd 内在性シアリダーゼ耐性ラクトン体含有組成物
JP2009073806A (ja) * 2007-08-27 2009-04-09 Iriya Cosmetics Co Ltd インスリン様成長因子−１分泌促進剤

Non-Patent Citations (1)

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Title
"Sialic acid", KAGAKU DAIJITEN 4, vol. 30TH PRI, 15 February 1987 (1987-02-15), pages 46 - 47 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013522234A (ja) * 2010-03-12 2013-06-13 ディーエスエム アイピー アセッツ ビー．ブイ． 母体へのシアル酸補給
CN104146885A (zh) * 2014-07-14 2014-11-19 武汉中科光谷绿色生物技术有限公司 N-乙酰神经氨酸水合物在育发产品中的应用
KR20170045275A (ko) * 2014-10-31 2017-04-26 가부시키 가이샤 파마푸즈 발모 및 육모 촉진제 및 이들의 이용
US10154684B2 (en) 2014-10-31 2018-12-18 Pharma Foods International Co., Ltd. Hair regrowth and growth promoter and use thereof
KR101966266B1 (ko) * 2014-10-31 2019-04-05 가부시키 가이샤 파마푸즈 발모 및 육모 촉진제 및 이들의 이용

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