WO2009126688A3 - Novel compositions and methods for the treatment of immune related diseases - Google Patents
Novel compositions and methods for the treatment of immune related diseases Download PDFInfo
- Publication number
- WO2009126688A3 WO2009126688A3 PCT/US2009/039868 US2009039868W WO2009126688A3 WO 2009126688 A3 WO2009126688 A3 WO 2009126688A3 US 2009039868 W US2009039868 W US 2009039868W WO 2009126688 A3 WO2009126688 A3 WO 2009126688A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- methods
- related diseases
- immune related
- novel compositions
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910073153.1A CN110082533B (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for treatment of immune-related diseases |
EP09730709.4A EP2279412B1 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
PL17152167T PL3208612T3 (en) | 2008-04-09 | 2009-04-08 | Compositions and methods for the treatment of immune related diseases |
BRPI0906550A BRPI0906550B8 (en) | 2008-04-09 | 2009-04-08 | Anti-tigit antibody, uses of an anti-tigit antibody, and in vitro methods to stimulate the cd226-pvr interaction and/or the cd96-pvr interaction, to enhance or stimulate the proliferation of a T cell or the release of proinflammatory cytokines by a dendritic cell, to enhance or stimulate the immune response of the T cell to enhance or stimulate the production of proinflammatory cytokines by a dendritic cell |
CN200980121734.2A CN102057272B (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
MX2013010169A MX364200B (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases. |
KR1020187034436A KR20180132156A (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
KR1020167036368A KR101855381B1 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
DK09730709.4T DK2279412T3 (en) | 2008-04-09 | 2009-04-08 | PRESENT UNKNOWN COMPOSITIONS AND PROCEDURES FOR TREATING IMMUNRATED DISEASES |
KR1020107025044A KR101692080B1 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
SI200931728T SI2279412T1 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
PL09730709T PL2279412T3 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
ES09730709.4T ES2640533T3 (en) | 2008-04-09 | 2009-04-08 | Compositions and novel methods for the treatment of diseases related to immunity |
AU2009233708A AU2009233708B2 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
EP19181712.1A EP3605088A1 (en) | 2008-04-09 | 2009-04-08 | Compositions and methods for the treatment of immune related diseases |
KR1020187012359A KR101924831B1 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
MX2010011088A MX2010011088A (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases. |
CA2719189A CA2719189C (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
EP17152167.7A EP3208612B1 (en) | 2008-04-09 | 2009-04-08 | Compositions and methods for the treatment of immune related diseases |
JP2011504145A JP5770624B2 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
IL208285A IL208285A0 (en) | 2008-04-09 | 2010-09-21 | Novel compositions and methods for the treatment of immune related diseases |
IL228988A IL228988A (en) | 2008-04-09 | 2013-10-21 | Antibody compositions for the treatment of immune related diseases |
AU2015202123A AU2015202123B2 (en) | 2008-04-09 | 2015-04-24 | Novel compositions and methods for the treatment of immune related diseases |
IL246293A IL246293B (en) | 2008-04-09 | 2016-06-16 | Novel compositions and methods for the treatment of immune related diseases |
AU2017221784A AU2017221784B2 (en) | 2008-04-09 | 2017-08-30 | Novel compositions and methods for the treatment of immune related diseases |
IL264498A IL264498B (en) | 2008-04-09 | 2019-01-28 | Novel compositions and methods for the treatment of immune related diseases |
AU2019257492A AU2019257492A1 (en) | 2008-04-09 | 2019-10-31 | Novel compositions and methods for the treatment of immune related diseases |
IL272817A IL272817A (en) | 2008-04-09 | 2020-02-20 | Novel compositions and methods for the treatment of immune related diseases |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12353008P | 2008-04-09 | 2008-04-09 | |
US61/123,530 | 2008-04-09 | ||
US19427108P | 2008-09-26 | 2008-09-26 | |
US61/194,271 | 2008-09-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009126688A2 WO2009126688A2 (en) | 2009-10-15 |
WO2009126688A3 true WO2009126688A3 (en) | 2009-12-10 |
WO2009126688A8 WO2009126688A8 (en) | 2010-06-03 |
Family
ID=40873503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/039868 WO2009126688A2 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
Country Status (18)
Country | Link |
---|---|
US (5) | US20090258013A1 (en) |
EP (3) | EP3605088A1 (en) |
JP (7) | JP5770624B2 (en) |
KR (4) | KR101855381B1 (en) |
CN (3) | CN110082533B (en) |
AU (1) | AU2009233708B2 (en) |
BR (1) | BRPI0906550B8 (en) |
CA (3) | CA3179151A1 (en) |
DK (1) | DK2279412T3 (en) |
ES (2) | ES2640533T3 (en) |
HK (1) | HK1211081A1 (en) |
HU (1) | HUE036780T2 (en) |
IL (5) | IL208285A0 (en) |
MX (3) | MX364200B (en) |
PL (2) | PL3208612T3 (en) |
SG (2) | SG10202112838YA (en) |
SI (1) | SI2279412T1 (en) |
WO (1) | WO2009126688A2 (en) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2357505T3 (en) | 2002-09-11 | 2011-04-27 | Genentech, Inc. | COMPOSITION AND NEW PROCEDURES FOR THE TREATMENT OF IMMUNORELATED DISEASES. |
CA3179151A1 (en) | 2008-04-09 | 2009-10-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
HUE061002T2 (en) | 2011-09-23 | 2023-04-28 | Mereo Biopharma 5 Inc | Vegf/dll4 binding agents and uses thereof |
CA2892831A1 (en) * | 2012-12-04 | 2014-06-12 | Oncomed Pharmaceuticals, Inc. | Immunotherapy with binding agents |
RU2019129525A (en) | 2013-07-16 | 2019-11-05 | Дженентек, Инк. | METHODS FOR TREATING CANCER USING ANTAGONISTS BINDING THE PD-1 AXIS AND TIGIT INHIBITORS |
WO2015006811A2 (en) * | 2013-07-19 | 2015-01-22 | The Walter And Eliza Hall Institute Of Medical Research | Diagnostic methods |
JP2016530267A (en) * | 2013-08-22 | 2016-09-29 | ザ・カウンシル・オヴ・ザ・クイーンズランド・インスティテュート・オヴ・メディカル・リサーチ | Immune receptor modulation to treat cancer and viral infections |
AU2014308552B2 (en) * | 2013-08-22 | 2020-02-13 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
EP3036258B1 (en) * | 2013-08-22 | 2023-07-19 | The Council of the Queensland Institute of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
CN103487572B (en) * | 2013-10-08 | 2017-03-29 | 北京大学人民医院 | Application of the folliculus helper T cell (Tfh) in autoimmune disease state of an illness early warning |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
EP3119913B1 (en) * | 2014-03-21 | 2021-01-06 | The Brigham and Women's Hospital, Inc. | Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring |
US9885021B2 (en) | 2014-06-12 | 2018-02-06 | Children's National Medical Center | Generation of broadly-specific, virus-immune cells targeting multiple HIV antigens for preventive and therapeutic use |
JP2017522311A (en) * | 2014-07-16 | 2017-08-10 | ジェネンテック, インコーポレイテッド | Method for treating cancer using TIGIT inhibitor and anticancer agent |
MY184288A (en) * | 2014-08-19 | 2021-03-30 | Merck Sharp & Dohme Llc | Anti-tigit antibodies |
AU2015343494A1 (en) * | 2014-11-06 | 2017-04-27 | Genentech, Inc. | Combination therapy comprising OX40 binding agonists and TIGIT inhibitors |
BR112017013385A2 (en) * | 2014-12-23 | 2018-02-06 | Bristol-Myers Squibb Company | antibodies to tigit |
MA41460A (en) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | TNFRSF LIAISON AGENTS AND THEIR USES |
SG11201706583PA (en) | 2015-02-19 | 2017-09-28 | Compugen Ltd | Anti-pvrig antibodies and methods of use |
EP3259597B1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
EP3875477A1 (en) | 2015-04-17 | 2021-09-08 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
US11022615B2 (en) * | 2015-05-04 | 2021-06-01 | University Of Florida Research Foundation, Inc. | Regulatory T-cells, method for their isolation and uses |
TWI715587B (en) * | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit-binding agents and uses thereof |
UY36687A (en) | 2015-05-29 | 2016-11-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | ANTIBODIES AGAINST OX40 AND ITS USES |
JO3620B1 (en) * | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | Immune-checkpoint inhibitors for use in the treatment of blood-borne cancers cancers |
EP3334757A4 (en) * | 2015-08-14 | 2019-04-03 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
CN107949573B (en) | 2015-09-01 | 2022-05-03 | 艾吉纳斯公司 | anti-PD-1 antibodies and methods of use thereof |
JP6861418B2 (en) * | 2015-09-02 | 2021-04-28 | イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | Antibodies specific for human T cell immunoglobulin and ITIM domain (TIGIT) |
AU2016322934A1 (en) * | 2015-09-14 | 2018-04-12 | Compass Therapeutics Llc | Compositions and methods for treating cancer via antagonism of the CD155/TIGIT pathway and TGF-beta |
EP3353204B1 (en) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
CR20180225A (en) * | 2015-09-25 | 2018-07-09 | Genentech Inc | ANTI-TIGIT ANTIBODY AND METHODS OF USE |
KR20180051651A (en) * | 2015-10-01 | 2018-05-16 | 히트 바이오로직스, 인코퍼레이티드 | Compositions and methods for adjacent I and II extracellular domains as heterologous chimeric proteins |
EP3356413B1 (en) * | 2015-10-01 | 2022-01-05 | Potenza Therapeutics, Inc. | Anti-tigit antigen-binding proteins and methods of use thereof |
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