WO2009117196A8 - Blocking the metastasis of cancer cells and the uses of new compounds thereof - Google Patents

Blocking the metastasis of cancer cells and the uses of new compounds thereof Download PDF

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Publication number
WO2009117196A8
WO2009117196A8 PCT/US2009/034115 US2009034115W WO2009117196A8 WO 2009117196 A8 WO2009117196 A8 WO 2009117196A8 US 2009034115 W US2009034115 W US 2009034115W WO 2009117196 A8 WO2009117196 A8 WO 2009117196A8
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
compounds
modulate
metastasis
methods
Prior art date
Application number
PCT/US2009/034115
Other languages
French (fr)
Other versions
WO2009117196A1 (en
Inventor
Pui-Kwong Chan
May Sung Mak
Original Assignee
Pacific Arrow Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/002086 external-priority patent/WO2008133766A1/en
Priority claimed from US12/344,682 external-priority patent/US8841265B2/en
Priority to CN200980112951.5A priority Critical patent/CN101998964B/en
Priority to CA2715501A priority patent/CA2715501A1/en
Priority to AU2009226063A priority patent/AU2009226063A1/en
Priority to EP09721583A priority patent/EP2254899A4/en
Application filed by Pacific Arrow Limited filed Critical Pacific Arrow Limited
Priority to US12/541,713 priority patent/US8735558B2/en
Publication of WO2009117196A1 publication Critical patent/WO2009117196A1/en
Publication of WO2009117196A8 publication Critical patent/WO2009117196A8/en
Priority to US12/856,322 priority patent/US8586719B2/en
Priority to US13/841,053 priority patent/US9382285B2/en
Priority to US15/181,631 priority patent/US10213451B2/en
Priority to US16/285,634 priority patent/US11046724B2/en
Priority to US17/362,028 priority patent/US20220024961A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)

Abstract

Methods for utilizing the anticancer properties of terpenoid saponin compounds so as to modulate adhesion proteins, inhibit angiogenesis in tumors, modulate gene expression, modulate angiopoietin, enhance an immune response, provide adjuvant activities, provide vaccine activities, or inhibit the metastasis of cancer cells when contacting a subject with the compounds, wherein the cancers compose breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervix cancer, esophagus cancer, testis cancer, spleen cancer, kidney cancer, lymph cancer, pancreas cancer, stomach cancer and thyroid cancer Methods, processes, compounds and compositions for antiparasitic applications which include inhibiting leishmaniases, amoebiasis, trypanosomiasis, toxoplasmosis or malaria
PCT/US2009/034115 2004-09-07 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof WO2009117196A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN200980112951.5A CN101998964B (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof
CA2715501A CA2715501A1 (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof
AU2009226063A AU2009226063A1 (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof
EP09721583A EP2254899A4 (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof
US12/541,713 US8735558B2 (en) 2005-02-14 2009-08-14 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US12/856,322 US8586719B2 (en) 2005-04-27 2010-08-13 Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US13/841,053 US9382285B2 (en) 2004-09-07 2013-03-15 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US15/181,631 US10213451B2 (en) 2004-09-07 2016-06-14 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US16/285,634 US11046724B2 (en) 2004-09-07 2019-02-26 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US17/362,028 US20220024961A1 (en) 2004-09-07 2021-06-29 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
USPCT/US2008/002086 2008-02-15
PCT/US2008/002086 WO2008133766A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US3827708P 2008-03-20 2008-03-20
US61/038,277 2008-03-20
US5430808P 2008-05-19 2008-05-19
US61/054,308 2008-05-19
US12/344,682 2008-12-29
US12/344,682 US8841265B2 (en) 2003-10-09 2008-12-29 Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US12/195,112 Continuation-In-Part US20090041877A1 (en) 2003-10-09 2008-08-20 Composition comprising growth factor of xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US12/344,682 Continuation-In-Part US8841265B2 (en) 2003-10-09 2008-12-29 Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10/906,303 Continuation-In-Part US7524824B2 (en) 2001-08-31 2005-02-14 Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US12/541,713 Continuation-In-Part US8735558B2 (en) 2004-09-07 2009-08-14 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US12/856,322 Continuation-In-Part US8586719B2 (en) 2005-04-27 2010-08-13 Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US13/718,575 Continuation-In-Part US20130190261A1 (en) 2001-08-31 2012-12-18 Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

Publications (2)

Publication Number Publication Date
WO2009117196A1 WO2009117196A1 (en) 2009-09-24
WO2009117196A8 true WO2009117196A8 (en) 2009-11-26

Family

ID=41091216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/034115 WO2009117196A1 (en) 2004-09-07 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof

Country Status (5)

Country Link
EP (1) EP2254899A4 (en)
CN (1) CN101998964B (en)
AU (1) AU2009226063A1 (en)
CA (1) CA2715501A1 (en)
WO (1) WO2009117196A1 (en)

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TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
CN114671923A (en) * 2010-07-16 2022-06-28 太平洋艾瑞有限公司 Novel compounds useful for the treatment of cancer and other diseases
KR101873607B1 (en) * 2010-07-16 2018-07-02 퍼시픽 애로우 리미티드 New compounds for treating cancer and other diseases
GB201016902D0 (en) 2010-10-07 2010-11-24 Chamberlain Luke A boiler assembly comprising a removable boiler unit
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
CN102851388B (en) * 2012-09-29 2014-03-19 山东大学齐鲁医院 Molecular marker for identifying susceptibility of ovarian cancer, kit and identifying method thereof
CN102864234B (en) * 2012-09-29 2014-03-19 山东大学齐鲁医院 Molecular marker for identifying susceptibility of ovarian cancer
CN104062432B (en) * 2013-03-22 2016-01-20 中山大学 The application of ang2 in preparation ECTC vascular group diagnosing cancer of liver reagent and medicine
US10987369B2 (en) 2014-04-10 2021-04-27 Academia Sinica Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes
CN103992236B (en) * 2014-04-29 2016-05-18 于非 A kind of New Target tropism antineoplastic and preparation method thereof and application
CN105467127B (en) * 2015-03-23 2017-06-06 复旦大学 The application process and its detection kit of a kind of human colon carcinoma protein markers COL6A3
WO2018045509A1 (en) * 2016-09-07 2018-03-15 武汉华大吉诺因生物科技有限公司 Polypeptide and application thereof
WO2018219342A1 (en) * 2017-06-01 2018-12-06 立森印迹诊断技术有限公司 Imprinted gene graded model and diagnostic method and application
CN107312855B (en) * 2017-07-24 2020-12-25 青岛泱深生物医药有限公司 Gene related to laryngeal squamous cell carcinoma and application thereof
CN107543926A (en) * 2017-08-25 2018-01-05 复旦大学附属金山医院 A kind of application of new Diagnosis of Breast invasive ductal carcinoma
TW201919644A (en) * 2017-09-29 2019-06-01 台灣浩鼎生技股份有限公司 Method for treating leukemia
CN108103194B (en) * 2017-12-27 2021-05-18 中国医学科学院药用植物研究所 Target for inhibiting gastric cancer cell MGC-803 and application thereof
CN108220421B (en) * 2018-01-05 2019-04-05 智海基因科技南京有限公司 The diagnostic kit and related gene of oneself immunity hepatitis are preparing the application in the kit
CN110272997B (en) * 2018-03-14 2023-04-28 华中科技大学同济医学院附属同济医院 Application of C/EBP beta gene or protein
CN108728539A (en) * 2018-06-05 2018-11-02 浙江大学 A kind of application of HoxD10 genes in gastric cancer
CN108840923B (en) * 2018-06-22 2021-08-03 上海交通大学医学院附属仁济医院 Polypeptide targeting PD-L1 and application thereof
CN108642181B (en) * 2018-06-25 2021-09-10 遵义医科大学附属医院 Application of long-chain non-coding RNA SLC25A25-AS1
CN111217900A (en) * 2018-11-27 2020-06-02 上海交通大学 Transcription regulation factor for angiogenesis and application thereof
CN111289749B (en) * 2018-12-10 2023-04-14 北京蛋白质组研究中心 Application of C-type 1-type Niemann-Pickerin detection substance in preparation of hepatocellular carcinoma screening product
CN109402119A (en) * 2018-12-11 2019-03-01 宁夏医科大学总医院 A kind of circular rna hsa_circTGFBI_001 and its specificity amplification primer and application
CN109402125A (en) * 2018-12-11 2019-03-01 宁夏医科大学总医院 A kind of circular rna hsa_circTGFBI_007 and its specificity amplification primer and application
CN110672848A (en) * 2019-10-25 2020-01-10 四川大学华西医院 Application of APEH autoantibody detection reagent in preparation of lung cancer screening kit
CN111153956B (en) * 2019-12-06 2020-12-11 江苏一片叶高新科技有限公司 Tea saponin compound, preparation method and application
CN110938630B (en) * 2019-12-20 2023-07-28 中国人民解放军第四军医大学 Application of human B3GNT5 gene and related products
CN111166769B (en) * 2020-03-18 2022-01-11 山东大学 Application of dermal fibroblast in treating melanoma
CN111979328B (en) * 2020-09-07 2022-10-14 复旦大学附属中山医院 Biomarker for predicting liver cancer lung metastasis and application thereof
CN112011620B (en) * 2020-09-23 2021-04-27 山东大学第二医院 Application of circ-SLC38A1 as target in medicine for inhibiting bladder cancer cells
CN112481373B (en) * 2020-12-21 2022-01-28 华北理工大学 circRNA detection kit for auxiliary diagnosis of autism

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140127B1 (en) * 1998-12-22 2004-06-16 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US8614197B2 (en) * 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups

Also Published As

Publication number Publication date
EP2254899A4 (en) 2012-05-30
CA2715501A1 (en) 2009-09-24
AU2009226063A1 (en) 2009-09-24
CN101998964B (en) 2015-05-06
WO2009117196A1 (en) 2009-09-24
CN101998964A (en) 2011-03-30
EP2254899A1 (en) 2010-12-01

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