WO2009103218A8 - Dérivés d'hydrazine carboxamide d'éthylidène, processus de préparation et utilisation pharmaceutique de ceux-ci - Google Patents

Dérivés d'hydrazine carboxamide d'éthylidène, processus de préparation et utilisation pharmaceutique de ceux-ci Download PDF

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Publication number
WO2009103218A8
WO2009103218A8 PCT/CN2009/000136 CN2009000136W WO2009103218A8 WO 2009103218 A8 WO2009103218 A8 WO 2009103218A8 CN 2009000136 W CN2009000136 W CN 2009000136W WO 2009103218 A8 WO2009103218 A8 WO 2009103218A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation process
pharmaceutical use
carboxamide derivatives
ethylidene
hydrazine carboxamide
Prior art date
Application number
PCT/CN2009/000136
Other languages
English (en)
Chinese (zh)
Other versions
WO2009103218A1 (fr
Inventor
邓炳初
吕贺军
陈一千
宋鹏
王胜蓝
Original Assignee
上海恒瑞医药有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海恒瑞医药有限公司 filed Critical 上海恒瑞医药有限公司
Priority to CN2009800002470A priority Critical patent/CN101679242B/zh
Publication of WO2009103218A1 publication Critical patent/WO2009103218A1/fr
Publication of WO2009103218A8 publication Critical patent/WO2009103218A8/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des dérivés d'hydrazide carboxamide d'éthylidène représentés par la formule (I) ou des sels, un hydrate ou un solvate pharmaceutiquement acceptables de ceux-ci, des procédés de préparation de ces dérivés, des compositions pharmaceutiques les contenants et leur utilisation comme agent thérapeutique, en particulier comme mimétiques de thrombopoïétine (TPO) et leur utilisation comme agonistes du récepteur de thrombopoïétine. Les définitions des substituants dans la formule (I) sont telles que présentées dans la description.
PCT/CN2009/000136 2008-02-21 2009-02-06 Dérivés d'hydrazine carboxamide d'éthylidène, processus de préparation et utilisation pharmaceutique de ceux-ci WO2009103218A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2009800002470A CN101679242B (zh) 2008-02-21 2009-02-06 亚乙基肼酰胺类衍生物、其制备方法及其在医药上的应用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200810006179.6 2008-02-21
CNA2008100061796A CN101514179A (zh) 2008-02-21 2008-02-21 吲哚酮亚乙基肼羰基化合物、其制备方法及其在医药上的应用

Publications (2)

Publication Number Publication Date
WO2009103218A1 WO2009103218A1 (fr) 2009-08-27
WO2009103218A8 true WO2009103218A8 (fr) 2009-12-03

Family

ID=40985060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2009/000136 WO2009103218A1 (fr) 2008-02-21 2009-02-06 Dérivés d'hydrazine carboxamide d'éthylidène, processus de préparation et utilisation pharmaceutique de ceux-ci

Country Status (2)

Country Link
CN (2) CN101514179A (fr)
WO (1) WO2009103218A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2492262B1 (fr) 2009-10-23 2016-04-20 Nissan Chemical Industries, Ltd. Composés hétérocycles fusionnés et activateur du récepteur de la thrombopoïétine
JP6072058B2 (ja) * 2011-11-14 2017-02-01 リガンド・ファーマシューティカルズ・インコーポレイテッド 顆粒球コロニー刺激因子受容体と結合する方法および組成物
WO2014150252A1 (fr) 2013-03-15 2014-09-25 Ligand Pharmaceuticals Incorporated Méthodes de traitement associées au récepteur du facteur de stimulation des colonies de granulocytes
CN104628647A (zh) * 2013-11-12 2015-05-20 上海医药工业研究院 3-甲基-1-(3,4-二甲基苯基)-2-吡唑啉-5-酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003032916A2 (fr) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfures inhibiteurs de tyrosine phosphatases
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
WO2006028970A1 (fr) * 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derives d'inhibiteurs de thiazole et de thiadiazole de tyrosine phosphatases
WO2006064957A1 (fr) * 2004-12-14 2006-06-22 Nissan Chemical Industries, Ltd. Compose d’amide et activateur du recepteur de la thrombopoietine
BRPI0620532A2 (pt) * 2005-11-23 2011-11-16 Ligand Pharm Inc compostos e métodos para modular a atividade de trombopoietina

Also Published As

Publication number Publication date
CN101514179A (zh) 2009-08-26
WO2009103218A1 (fr) 2009-08-27
CN101679242A (zh) 2010-03-24
CN101679242B (zh) 2013-07-10

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